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3. Terminal

Author

Hardy, Linda

Published
2009

11. Musashi exerts control of gonadotrope target mRNA translation during the mouse estrous cycle

Author

Moreira, Ana Rita Silva, primary, Lim, Juchan, additional, Urbaniak, Alicja, additional, Banik, Jewel, additional, Bronson, Katherine, additional, Lagasse, Alex, additional, Hardy, Linda, additional, Haney, Anessa, additional, Allensworth, Melody, additional, Miles, Tiffany K, additional, Gies, Allen, additional, Byrum, Stephanie D, additional, Wilczynska, Ania, additional, Boehm, Ulrich, additional, Kharas, Michael, additional, Lengner, Christopher, additional, MacNicol, Melanie C, additional, Childs, Gwen V, additional, MacNicol, Angus M, additional, and Odle, Angela K, additional

Published
2023
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14. RF25 | PMON50 Insight into Integrated Control of Pituitary Function Revealed Through Analysis of Musashi Target mRNAs

Author

Lim, Juchan, primary, Banik, Jewel, additional, Urbaniak, Alicja, additional, Bronson, Katherine, additional, Tomlinson, Sophia, additional, Hardy, Linda, additional, Gies, Allen, additional, Byrum, Stephanie, additional, Wilczynska, Ania, additional, MacNicol, Melanie, additional, Childs, Gwen, additional, and MacNicol, Angus, additional

Published
2022
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20. Control of the Anterior Pituitary Cell Lineage Regulator POU1F1 by the Stem Cell Determinant Musashi

Author

Allensworth-James, Melody, primary, Banik, Jewel, additional, Odle, Angela, additional, Hardy, Linda, additional, Lagasse, Alex, additional, Moreira, Ana Rita Silva, additional, Bird, Jordan, additional, Thomas, Christian L, additional, Avaritt, Nathan, additional, Kharas, Michael G, additional, Lengner, Christopher J, additional, Byrum, Stephanie D, additional, MacNicol, Melanie C, additional, Childs, Gwen V, additional, and MacNicol, Angus M, additional

Published
2020
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22. SAT-284 Musashi Exerts Translational Control Within Anterior Pituitary Cells of the POU1F1 Lineage

Author

Allensworth, Melody Lyn, primary, Odle, Angela Katherine, primary, Moreira, Ana Rita Silva, primary, Lim, Juchan, primary, Banik, Jewel, primary, Haney, Anessa, primary, Lagasse, Alex, primary, Hardy, Linda, primary, Byrum, Stephanie, primary, Avaritt, Nathan, primary, MacNicol, Melanie C, primary, Childs, Gwen V, primary, and MacNicol, Angus M, primary

Published
2020
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25. Against the Grain.

Author

Hardy, Linda Lucas

Subjects
INTERNET searching, ROAD maps
Abstract

STAGE 6 CLEANING THE PAPER WITH TACKY While working, colored pencil pigment floats across the paper which makes it dirty, more so with sandpaper. STAGE 11 FINISHED ARTWORK Gorgeosity, colored pencil on 800-grain sandpaper, 10x10" (25 × 25 cm) The last thing I do is reinforce the lightest areas with heavy pressure then seal the piece with a UV spray. The wax-based pigment will blend whereas the other pigments tend to sweep off the sandpaper. [Extracted from the article]

Published
2022

26. Milton's Manly Angels

Author

Hardy, Linda, Walls, Kathryn, Miles, Geoff, Lissington, Thomas, Hardy, Linda, Walls, Kathryn, Miles, Geoff, and Lissington, Thomas

Abstract

The masculine nature of the angels in Paradise Lost, in conjunction with their sexuality as revealed in Book VIII, prompted C. S. Lewis to try and explain away, not entirely convincingly, any potential “homosexual promiscuity” in his Preface to the epic. But other critics are unconcerned about the angels’ sexuality, probably because, unlike Lewis, they see them as essentially immaterial beings. In what follows I argue that a complete understanding of the angels’ sexuality must rest on Milton’s gradual revelation of the angels’ morphic substance, critical to their sexuality and gender identity. Milton’s use of the conventions associated with classical pastoral in depicting the angels suggests a male homosocial model analogous with the learning institutions of Milton’s own historical context – helpful when it comes to establishing the type of society, and relationships, in the heaven of Paradise Lost. Similarly, an exploration of bi-erotic elements occurring elsewhere within the Miltonic canon helps contextualise the bisexual potential of angelic desire. With these things in mind, a comprehensive understanding of the angelic sexuality can be achieved through close study of instances of desire, and sexuality, in Paradise Lost. The strong parallel between the angels, and Adam and Eve infers the potential for their descendants to evolve into a similar state of intimacy free of “Of membrane, joynt, or limb, exclusive barrs”.

Published
2019

29. The World Around Us.

Author

Cartaya, Alma, Vasil, Christopher, Taggart, Kim, Lindamood, Patsy, Wheeler, Alyssa, DiNapoli, Gregory, Junget, Andre Paul, Zhang, Jasmine, Dixon, Lorri, Hardy, Linda Lucas, Howard, Denise J., Panchul, Sayaka, Naras, Rita, and Rubin, Susan

Subjects
ART materials, COLOR wheels, SENSITIVE plant, COLOR in nature, FOREST resilience
Abstract

[LEFT] ABANDONED RAILS Rita Naras (graphite pencils on Claybord, 18x24) After many years of using a variety of media, my art materials are now pared down to the basics - just graphite pencils and hot-pressed illustration board or ultra-smooth Claybord. PHOTO (COLOR) PHOTO (COLOR) PHOTO (COLOR) PHOTO (COLOR) PHOTO (COLOR) PHOTO (COLOR) PHOTO (BLACK & WHITE) PHOTO (BLACK & WHITE) PHOTO (BLACK & WHITE) PHOTO (BLACK & WHITE) PHOTO (BLACK & WHITE) PHOTO (BLACK & WHITE) PHOTO (BLACK & WHITE) PHOTO (BLACK & WHITE) LIVING COLOR Susan Rubin (colored pencil and PanPastel on Mylar film, 17x17) Strolling through Montmartre in Paris, I came upon this manhole cover painted with a street-art color wheel. [Extracted from the article]

Published
2022

30. Control of the Anterior Pituitary Cell Lineage Regulator POU1F1 by the Stem Cell Determinant Musashi.

Author

Allensworth-James, Melody, Banik, Jewel, Odle, Angela, Hardy, Linda, Lagasse, Alex, Moreira, Ana Rita Silva, Bird, Jordan, Thomas, Christian L, Avaritt, Nathan, Kharas, Michael G, Lengner, Christopher J, Byrum, Stephanie D, MacNicol, Melanie C, Childs, Gwen V, and MacNicol, Angus M

Subjects
STEM cells, LEPTIN receptors, SOMATOTROPIN, NUCLEOTIDE sequence, TRANSCRIPTION factors
Abstract

The adipokine leptin regulates energy homeostasis through ubiquitously expressed leptin receptors. Leptin has a number of major signaling targets in the brain, including cells of the anterior pituitary (AP). We have previously reported that mice lacking leptin receptors in AP somatotropes display growth hormone (GH) deficiency, metabolic dysfunction, and adult-onset obesity. Among other targets, leptin signaling promotes increased levels of the pituitary transcription factor POU1F1, which in turn regulates the specification of somatotrope, lactotrope, and thyrotrope cell lineages within the AP. Leptin's mechanism of action on somatotropes is sex dependent, with females demonstrating posttranscriptional control of Pou1f1 messenger RNA (mRNA) translation. Here, we report that the stem cell marker and mRNA translational control protein, Musashi1, exerts repression of the Pou1f1 mRNA. In female somatotropes, Msi1 mRNA and protein levels are increased in the mouse model that lacks leptin signaling (Gh -CRE Lepr -null), coincident with lack of POU1f1 protein, despite normal levels of Pou1f1 mRNA. Single-cell RNA sequencing of pituitary cells from control female animals indicates that both Msi1 and Pou1f1 mRNAs are expressed in Gh -expressing somatotropes, and immunocytochemistry confirms that Musashi1 protein is present in the somatotrope cell population. We demonstrate that Musashi interacts directly with the Pou1f1 mRNA 3′ untranslated region and exerts translational repression of a Pou1f1 mRNA translation reporter in a leptin-sensitive manner. Musashi immunoprecipitation from whole pituitary reveals coassociated Pou1f1 mRNA. These findings suggest a mechanism in which leptin stimulation is required to reverse Musashi-mediated Pou1f1 mRNA translational control to coordinate AP somatotrope function with metabolic status. [ABSTRACT FROM AUTHOR]

Published
2021
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32. Association of Gnrhr mRNA With the Stem Cell Determinant Musashi: A Mechanism for Leptin-Mediated Modulation of GnRHR Expression

Author

Odle, Angela K, primary, Beneš, Helen, additional, Melgar Castillo, Andrea, additional, Akhter, Noor, additional, Syed, Mohsin, additional, Haney, Anessa, additional, Allensworth-James, Melody, additional, Hardy, Linda, additional, Winter, Benjamin, additional, Manoharan, Ragul, additional, Syed, Raiyan, additional, MacNicol, Melanie C, additional, MacNicol, Angus M, additional, and Childs, Gwen V, additional

Published
2017
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33. Evasion of regulatory phosphorylation by an alternatively spliced isoform of Musashi2

Author

MacNicol, Melanie C., primary, Cragle, Chad E., additional, McDaniel, F. Kennedy, additional, Hardy, Linda L., additional, Wang, Yan, additional, Arumugam, Karthik, additional, Rahmatallah, Yasir, additional, Glazko, Galina V., additional, Wilczynska, Ania, additional, Childs, Gwen V., additional, Zhou, Daohong, additional, and MacNicol, Angus M., additional

Published
2017
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37. Democratic Intellect: Freeing Thought for the Democracy To-come

Author

Opie, Brian, Hardy, LInda, Porkoli, Jafar Mirzaee, Opie, Brian, Hardy, LInda, and Porkoli, Jafar Mirzaee

Abstract

The core argument of this thesis is on the aporetic moment/space of decision and the poetics of the to-come in John Milton's works, with the fundamental importance of the individual. For Milton, this moment/space is radically critical and free, and individually problematic, which goes beyond the usual private/public space even though the public aspects and responsibilities of the person's decision demonstrate exceptional significance in the form of public enactment. In Milton's terms, the experience of such an aporetic moment/space of decision is indispensible for those who want to become a "fit reader" and develop the essential qualities and attributes. I will argue that Milton has always written with the desire to highlight and exemplify the absolute singularity of such a moment and experience throughout his life and works, both prose and poetry. The thesis will represent its arguments in two sections. The first section, through a consideration of Derrida's arguments in his works (in particular: "The Laws of Reflection: Nelson Mandela, in Admiration," "The Future of the Profession or the Unconditional University," "Force of Law: 'The Mystical Foundation of Authority,'" and "This Strange Institution Called Literature") together with a selection of Milton's writings, mainly prose (including: Areopagitica, Eikonoklastes, The Tenure of Kings and Magistrates, and Paradise Lost), will examine and identify possible continuities and convergences between the two writers. Such an intimate juxtaposition and close reading of their works has promisingly offered recognition of continuities, convergences, and affinities in their thought in terms of the qualities and attributes of the "fit reader" and the "democratic intellect." In the opening five chapters, the interactive reading highlights fundamental questions and notions for both writers, including the question of exemplarity or singularity, the notion of public space without conditions, the question of justice beyond the la

Published
2013

41. Bedside Handover

Author

Chaboyer, Wendy, primary, McMurray, Anne, additional, Johnson, Joanne, additional, Hardy, Linda, additional, Wallis, Marianne, additional, and (Sylvia) Chu, Fang Ying, additional

Published
2009
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42. Teton Wilderness Action Plan and Implementation Schedule

Author

Kathryn D. Hardy, Linda Merigliano and Kathryn D. Hardy, Linda Merigliano

Abstract

This paper was prepared as a student project in partial fulfillment of the requirements of the Professional Development for Outdoor Recreation Management Program at Clemson University. It in no way reflects USDA Forest Service policy nor are the opinions expressed those of anyone other than the author.

Published
1996

44. Vanishing Lobo

Author

Hardy, Linda

Subjects
Vanishing Lobo (Book) -- Book reviews, Books -- Book reviews
Published
1991

47. Bedside Handover: Quality Improvement Strategy to "Transform Care at the Bedside".

Author

Cbaboyer, Wendy, McMurray, Anne, Johnson, Joanne, Hardy, Linda, Wallis, Marianne, and Fang Ying (Sylvia) Chu

Subjects
NURSING, HOSPITAL wards, MEDICAL practice, MEDICAL care, SICK people
Abstract

This quality improvement project implemented bedside handover in nursing. Using Lewin's 3-Step Model for Change, 3 wards in an Australian hospital changed from verbal reporting in an isolated room to bedside handover. Practice guidelines and a competency standard were developed. The change was received positively by both staff and patients. Staff members reported that bedside handover improved safety efficiency, teamwork, and the level of support from senior staff members. [ABSTRACT FROM AUTHOR]

Published
2009
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48. Exploring the Concept of Race and Its Implications for Health Disparities Research.

Author

Hardy, Linda K.

Subjects
*RACISM, *RACIAL differences, *ETHNOCRACY, *PUBLIC health, *HEALTH equity
Abstract

Racial classifications are commonly used by the US. government and other social institutions, but the concept of race is complex and poorly defined. Current public health goals include addressing health disparities related to race. Unclear and inconsistent use of terminology related to various populations obscures attempts to identify and address health disparities. The purpose of this work is to explore the concept of race and offer recommendations for nursing research efforts directed at addressing health disparities. [ABSTRACT FROM AUTHOR]

Published
2007

50. The Red Shirt

Author

Hardy, Linda

Subjects
The Red Shirt (Book) -- Book reviews, Books -- Book reviews
Published
1992

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