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1. Developing Treatment Guidelines During a Pandemic Health Crisis: Lessons Learned From COVID-19

Author

Kuriakose, Safia, Singh, Kanal, Pau, Alice K, Daar, Eric, Gandhi, Rajesh, Tebas, Pablo, Evans, Laura, Gulick, Roy M, Lane, H Clifford, Masur, Henry, Aberg, Judith A, Adimora, Adaora A, Baker, Jason, Kreuziger, Lisa Baumann, Bedimo, Roger, Belperio, Pamela S, Cantrill, Stephen V, Coopersmith, Craig M, Davis, Susan L, Dzierba, Amy L, Gallagher, John J, Glidden, David V, Grund, Birgit, Hardy, Erica J, Hinkson, Carl, Hughes, Brenna L, Johnson, Steven, Keller, Marla J, Kim, Arthur Y, Lennox, Jeffrey L, Levy, Mitchell M, Li, Jonathan Z, Martin, Greg S, Naggie, Susanna, Pavia, Andrew T, Seam, Nitin, Simpson, Steven Q, Swindells, Susan, Tien, Phyllis, Waghmare, Alpana A, Wilson, Kevin C, Yazdany, Jinoos, Zachariah, Philip, Campbell, Danielle M, Harrison, Carly, Burgess, Timothy, Francis, Joseph, Sheikh, Virginia, Uyeki, Timothy M, Walker, Robert, Brooks, John T, Ortiz, Laura Bosque, Davey, Richard T, Doepel, Laurie K, Eisinger, Robert W, Han, Alison, Higgs, Elizabeth S, Nason, Martha C, Crew, Page, Lerner, Andrea M, Lund, Claire, and Worthington, Christopher

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Health Services, Clinical Research, Generic health relevance, Good Health and Well Being, Advisory Committees, COVID-19, Child, Data Interpretation, Statistical, Drug Approval, Evidence-Based Medicine, Female, Humans, Interprofessional Relations, National Institutes of Health (U.S.), Pandemics, Practice Guidelines as Topic, Pregnancy, SARS-CoV-2, Stakeholder Participation, United States, COVID-19 Drug Treatment, NIH COVID-19 Treatment Guidelines Panel, Medical and Health Sciences, General & Internal Medicine, Clinical sciences
Abstract

The development of the National Institutes of Health (NIH) COVID-19 Treatment Guidelines began in March 2020 in response to a request from the White House Coronavirus Task Force. Within 4 days of the request, the NIH COVID-19 Treatment Guidelines Panel was established and the first meeting took place (virtually-as did subsequent meetings). The Panel comprises 57 individuals representing 6 governmental agencies, 11 professional societies, and 33 medical centers, plus 2 community members, who have worked together to create and frequently update the guidelines on the basis of evidence from the most recent clinical studies available. The initial version of the guidelines was completed within 2 weeks and posted online on 21 April 2020. Initially, sparse evidence was available to guide COVID-19 treatment recommendations. However, treatment data rapidly accrued based on results from clinical studies that used various study designs and evaluated different therapeutic agents and approaches. Data have continued to evolve at a rapid pace, leading to 24 revisions and updates of the guidelines in the first year. This process has provided important lessons for responding to an unprecedented public health emergency: Providers and stakeholders are eager to access credible, current treatment guidelines; governmental agencies, professional societies, and health care leaders can work together effectively and expeditiously; panelists from various disciplines, including biostatistics, are important for quickly developing well-informed recommendations; well-powered randomized clinical trials continue to provide the most compelling evidence to guide treatment recommendations; treatment recommendations need to be developed in a confidential setting free from external pressures; development of a user-friendly, web-based format for communicating with health care providers requires substantial administrative support; and frequent updates are necessary as clinical evidence rapidly emerges.

Published
2021

13. Contributors

Author

Abdelazeem, Mohamed A., Abelman, Rebecca A., Abrantes, Tatiana F., Afari, Maxwell Eyram, Afarideh, Mohsen, Ahmad, Ali, Ahn-Horst, Rosa, Akoto, Shanice, AlAbdulhadi, Abrar, Albright, J. Alex, Sierra, Maria Aldana, Ali, Tanya, Alipanah-Lechner, Narges, Anderson, Chelsea Bloom, Anderson, Chelsie, Anilowski, Kathryn Taylor, Anthony, Anngene, Aoun, Joe, Asaro, Joseph A., Asemota, Daniel, Asiedu, Daniel K., Astsaturov, Artem, Aulakh, Sudeep K., Avasare, Rupali, Babar, Tania B., Bachman, Emelia Argyropoulos, Bains, Ashika, Balaguera, Pedro, Bank, T. Caroline, Banwell, Brenda, Basman, Craig L., Bass, Crystal T., Beausang, Jasjit, Belcher, Ren, Bell, Jennifer, Bellinghausen, Amy L., Bennett, Colleen E., Benson, Nicole M., Bergen, Michael, Berger, Agatha, Berkowitz, Carol D., Bevington, Kristin, Bhagat, Vicky H., Bharmal, Murtaza, Bhatt, Harikrashna B., Bhuptani, Prachi H., Bido-Medina, Richard O., Bielak, Kendall, Bilodeau, Courtney Clark, Bird, Lisa, Bishop, Erin, Bissonette, Stefani, Bitar, Ghamar, Black, Julia E., Blakeney, Craig, Bland, Lauren, Blankenhorn, Brad, Block, Brian, Bochner, Risa, Boduch, Abigail N., Bortz, Christina M., Bouton, Tara C., Bove, Mary E., Bowlby, Lynn A., Box, Amanda, Brady, Mark F., Bratman, Russell E., Brennan, Keith, Bridges, Amy, Brown, Austin K., Brown, Emily, Bui, Eric, Burke, Christine, Burstein, Eleanor, Butler, William, Byanova, Katerina L., Caffrey, A. Gwendolyn, Cahill, Kate, Callanan, Tucker C., Campbell, Taylor, Canty, Katherine W., Cao, Damon H., Caraganis, Andrew, Carpenter, Randy S., Carragee, Eugene, Carrel-Lammert, Meredith, Carter, Ashlie Sewdass, Casillas, Ernesto, Jr., Castellon, Chrystina, Castillo, Jorge J., Catana, Andreea M., Cerezo, Carolina S., Chan, Philip A., Chang, Jacqueline, Chapman, Arlene, Chatterjee-Paer, Sudeshna, Chen, Kevin, Cheng, Vicky, Chin, Robin, Chofay, Dana Ricci, Cholankeril, George, Cholankeril, Rosann, Chou, Jonathan, Chou, Stella T., Choudhury, Natasha, Choxi, Shivali, Christian, Cindy W., Chua, Winona, Claman, David, Clark, Seth, Clarke, Nathan, Clebak, Karl T., Lawrenz, Michael, Cohen, Debbie L., Cohen, Lisa, Cohoon, Travis J., Congdon, Morgan, Constantinou, Maria, Copelin, Eddie L., II, Corley, James Earl, III, Cosgrove, Abigail, Craine, Rebecca, Cristofaro, Patricia, Cruz, Aristides I., Cunningham, Karlene, Curtin, Alicia J., Cusano, Joseph, Dabiri, Ganary, Dado, Lynn, Daly, Gerard H., Dan, Joshua, Dang, Frances, Dash, Miriam E., Dasilva, Manuel F., Davis, Mackenzie, Dedent, Alison, DeJong, Tyler, Denninger, John, Deol, Bisman, Desrochers, Colette, Devon, Erin Pete, Diaz, Joseph A., Dickherber, Jason L., DiMaria, Stephen, Disilvestro, Kevin J., Dohlman, Thomas H., Domenichini, David J., Doo, Kathleen, Dove, James H., Dubanchet, Alexandre, Dudley, John, Dutta, Roop, Dwivedi, Shashank, Dyster, Timothy G., Edmund, Joseph, Eggers, Erica, Eickhoff, Evlyn, Eisenhower, Christine, Ellsworth, Pamela, England, Melissa, Epstein, Alan, Espinosa, Patricio Sebastian, Evanoff, Anastasia, Everly, Eileen, Faber, Mark D., Fabio, Mary, Facer, Evan, Fadale, Paul, Fagan, Matthew J., Fallon, Ryan T., Farkas, Jon, Farrand, Erica, Fay, Kevin, Fernandez-Robles, Carlos, Ferreira, Jason D., Ferreira, Kaio S., Ferri, Fred F., Ferri, Heather, Fischer, Staci A., Wolpert, Marlene Fishman, Forbes, Kellie C., Forcier, Michelle, Ford, Sydney, Fort, Frank G., Fort, Glenn G., Freeman, Nancy, Fricchione, Gregory L., Frisch, Daniel R., Fru, Relindis Azenwi, Gasga, Arturo, Gentile, Tatiana Londoño, Gesthalter, Yaron B., Ghergurovich, Jonathan M., Gibson, Christopher, Gidwani, Nisha H., Gil, Joseph, Gilek-Seibert, Katarzyna, Gitelmaker, Dimitri, Gold, Raphaela, Goldburt, Alla, Goldfarb, Danielle, Goldsmith, Corey Elam, Gangadhara Rao Golla, Maheswara Satya, Gomez, Alexander, Gomez Slagle, Helen B., Gordon, Paul, Gorman, Deirdre C., Greenfield, Morgan, Grisham, Lindsey Anne, Guardino, Cara, Gultawatvichai, Patan, Guo, David, Gupta, Priya Sarin, Guttadauria, Brittany, Guzman, Herodes, Hack, Nawaz K.A., Hafeez, Muhammad Ubaid, Hajmohamed, Sherine, Hall, Sarah, Hallstead, Serica J., Handa, Sajeev, Handler, Stacy N., Harbord, Nikolas, Hardy, Erica J., Haribhakti, Nirav, Hartnett, Davis A., Hartvigsen, Nathan, Havele, Sonia A., Hawkins, Brian, Heinle, Rachel Wright, Helm, Leesha A., Helm, Matthew F., Hennebery, Ruth B., Herek, Jyothsna I., Hladky, Katherine, Hmoud, Hosam, Hodges, Ashley, Hoffman, R. Scott, Hogan, Dawn, Holderread, Brendan, Holiman, Jennifer J., Holland, N. Wilson, Holmes, Karima A., Holton, Siri M., Hsu, Raymond, Huang, Elena, Huang, Laurence, Hull, Mariam, Hume, Anne L., Hussain, Zilla, Hutchinson, Anne, Huynh, Donny V., Hyder, Sarah, Ibrahim, Zainab, Ingraham, Caitlin, Inman, Nicholas J., Innes, Brendan, Insalaco, Louis F., Isennock, Christopher, Ivkovic, Ana, Jafri, S. Hammad, Jain, Koyal, Jain, Vanita B.D., Jain, Vipul V., Jamal, Fariha, Jamil, Marcus L., Jamil, Nadia, Janigian, Robert H., Jr., Jasuja, Sonia, Javier, Noelle Marie, Jetty, Vybhav, Johl, Michael, Johnson, Michael P., Johnson, Steven D., Jolly, Angad, Jonas, Rebecca, Joshi, Shyam, Justice, Joshua, Kansara, Tikal, Karthikeyan, Vanji, Kass, Joseph S., Kass, Naomi R., Katarincic, Julia, Kaul, Bhavika, Kaur, Gurmehr, Kavandi, Hadiseh, Keleshian, Vasken, Keogh, Abigail, Kerrigan, Danielle, Keselman, Dennis, Khan, Adeeba, Khan, Rizwan, Khare, Sarthak, Khawaja, Hussain R., Ellen Kim, Eun Kyung, Kirchner, Robert M., Kodra, Arber, Kogan, Lawrence, Kohrman, Samuel I., Kojic, Erna Milunka, Kokkirala, Aravind Rao, Konstantino, Yuval, Kopyt, Nelson, Kosinski, Lindsay R., Kothadia, Savan, Koti, Ajay, Koulouridis, Ioannis, Kovacevic, Natalija, Kreider, Timothy R., Krishnamohan, Prashanth, Krueger, Van S., Kukreja, Mohit, Kumbar, Lalathaksha, Kuris, Eren O., Kurss, David I., Kutschke, Michael, L’Etoile, Nathan, Lacasce, Ann S., Lam, Uyen T., Lama, Christopher J., Lapite, Ajibike, Lau, Julianna, Leard, Lorriana E., Leavitt, David A., Leba, Christopher T., Lee, Kachiu C., Lee, Yvonne, Lemme, Nicholas J., Lento, René, Li, Jian, Lieberman, Leora, Lin, Erica, Lipner, Kaitlin, Lippincott, Jordan, Liu, Jonathan, London, Stephanie, López, Gabriela, Lord, Kito Akin, Lee Lowery, Curtis (Trey), III, Lucier, David J., Jr., Luther, Lauren, Ma’ayeh, Marwan, Maciag, Michelle C., MacKrell, Katherine, Maclean, Rachel L., MacMurdo, Maeve G., Madva, Elizabeth N., Makai, Gretchen, Makiyil, Jaibel, Malcolm, Katherine, Marcaccio, Stephen E., Marino, Daniel, Masaki, Charles, Mataya, Leslie, Matson, Kelly L., Mazzaglia, Peter J., Mbuyi, Nadine, McCrae, Brian, Jr., McCulloh, Russell J., McDonald, Christopher L., McGowen, Alexandra, McGuire, Leah, McGuirk, Barbara, McKenna, Jaclyn, McNamara, Kelly, Bido Medina, Richard Oliver, Meghani, Ozair K., Mercado, Jorge, Merrill, Scott J., Merritt, Rory, Metcalfe-Klaw, Robin, Michaels, Marian G., Michel, Jeremy, Midha, Shonali, Mikolasko, Brian D., Milner, John, Minami, Taro, Mitsuyama, Rei, Modest, Jacob M., Monhollon, Ethan, Montgrain, Philippe, Morelli, Leah, Morrissey, Patrick J., Mughal, Aleem I., Mukkamalla, Shiva Kumar R., Mullersman, Katherine M., Myers, Ellen, Mylhousen, Emily, Nadeem, Omar, Najem, Catherine E., Nandi, Minesh, Nasir, Uzma, Naveed, Asim, Neff, Robert, Neithardt, Adrienne B., Nelin, Timothy, Nestlerode, Christina, Ni, Samantha, Nokoff, Natalie, Novak, James E., Al Nuaimi, Saif K., Nuss, Emily E., O’Donnell, Ryan M., Oliver, Rebecca, Olszewski, Adam J., Onderko, Laura, Onyeaka, Henry K., Orchowski, Lindsay M., Osborne, Ashley D., Ovide, Gerry, Owens, Brett D., Oyelakin, Ayotomide, Pace, Paolo G., Palma-Zamora, Isaac, Papaila, Alexa, Pappas-Taffer, Lisa, Parekh, Maria A., Pares, Marco, Parikh, Mihir, Parikh, Shivani, Partin, Michael T., Patel, Birju B., Patel, Devan D., Patel, Melissa D., Patel, Nima R., Patel, Pranav M., Patrick, Brett, Pattni, Chandni, Paudel, Shreedhar, Paul, Ritika, Paxton, E. Scott, Peay, Celeste, Perazella, Mark, Perez, Alyssa, Perez, David L., Pfeuti, Courtney, Pham, Lily C., Pham, Long, Phillips, Katharine A., Phillips, Oliver W., Piana, Lauren E., Plante, Wendy A., Plumley, Kevin V., Powell, Mitchell, Powers, Alexander, Prashar, Rohini, Priestly, Margaret, Pulice, Christine, Punko, Diana, Puthawala, Imran, Qawi, Imrana, Quesada, Adrian, Rachu, Gregory S, Radhakrishnan, Parvathi, Raducha, Jeremy E., Rafeq, Samaan, Ranieri, Gina, Rathore, Bharti, Rathore, Ritesh, Raukar, Neha P., Reagan, John L., Reddy, Bharathi V., Reddy, Snigdha T., Reed-Weston, Anne, Reginato, Anthony M., Reichart, James P., Reinhart, Michaela B., Restrepo, Judith A., Reus, Victor I., Rich, Harlan G., Riotto, Giancarlo, Rivera, Alvaro M., Rivera, Lauren Davis, Roberts, Todd F., Robertson, Melena J., Roche, Meaghan, Rodarte, Patricia, Morfin Rodriguez, Alejandra E., Romero Gómez, Perla M., Roof, Tucker J., Rosenbaum, Blake L., Roussel, Breton, Rubeor, Amity, Rubin, David, Ruhstaller, Kelly, Sadeghi, Noushine, Saeed, Firrah, Sahota, Ruchi Jalota, Saks, Emily, Sall, Jeffrey W., Salvi, Joshua D., Samaniego-Picota, Milagros, Santhosh, Lekshmi, Santos, Linda Herrera, Satpathy, Hemant K., Satpathy, Ruby K., Sauck, Emily, Sayeed, Syeda M., Saylor, Leah, Scaramangas-Plumley, Daphne, Scheel, Paul J., Jr., Schlussel, Bradley, Schmitt, Heiko, Schnitzer, Kristina, Sciscione, Anthony, Scott, Matthew Thomas, Seeber, Richard E., II, Seijo, Leslie, Selby, Sasha L., Sell, Peter J., Sewell, Rachel, Shaban, Hesham, Shah, Ankur, Ali Shaikh, Aaron, Sharma, Animesh, Sharma, Yuvraj, Sharp, Lydia, Shea, Timothy, Sherman, Alexander, Shill, Jessica E., Shimanovsky, Alexei, Shlossman, Philip A., Siddiqui, Khawja A., Siegel, Alyssa, Sigman, Mark, Silber, Zachary S., Singh, Harinder P., Singhal, Divya, Sittard, Lauren, Slingsby, Brett, Sloane, Amy, Smick, Alexandra H., Smith, Devon, Smith, Jeanette G., Smith, Matthew J, Shain, Rachel Smith, Sohaney, Ryann, Soi, Vivek, Soinski, Rebecca, Soler, Maria E., Soman, Sandeep, Song, Jeffrey S., Sorg, Emily, Sperati, C. John, Sprow, Grant, Stern, Diana, Stern, Ella, Stockwell, Philip, Suh, Edward, Sun, Jennifer K., Sundaramoorthy, Anjali, Suppogu, Nissi, Sutter, Stephanie, Sweeney, Hannah, Tabatabavakili, Sahar, Tabba, Maher, Takasaki, Kaoru, Takei, Ryosuke, Talley-Bruns, Rachel, Tammaro, Dominick, Tan, Laren, Taylor, Alan, Taylor, S. Trevor, Tellioglu, Tahir, Testa, Edward J., Thomas, Anthony G., Tibbetts, Erin, Tien, Alexandra Meyer, Tien, David Robbins, Tierney, Anna-Marie, Tiffany, Patrick, Tillquist, Kristen, Toma, Helen, Triplett, Thomas M., Trivedi, Hirsh D., Tryforos, Margaret, Tsaban, Gal, Tucci, Joseph R., Turco, David, Turock, Julia, Tyree, Griffin A., Uduman, Junior, Uiterwyk, Sean H., Ukaegbu, Rebecca, Umanth, Kausik, Vakili, Babak, van Kirk, Emily, Vemula, Ridhima, Venado, Aida, Vijayakumar, Shilpa, Vollum, Kathryn G., Vorel, Ethan, Wagner, Brent T., Walesko, Mary-Beth, Walsh, Devin, Walsh, Ryan, Walson, Ifeanyi, Wang, Angela, Wang, Danielle, Wang, Jarey H., Wang, Stephani C., Wang, Tisha, Weinberg, Marc S., Westreich, Roi, Wilhoite, Morgan, Wilson, Annise, Wilson, Joshua, Winikor, Jared M., Wininger, Bryce, Winokur, Daniel, Wutawunashe, Caleb V., Wylie, John, Xiao, Yasi, Xu, Jennifer, Yang, Anna, Yarimi, Jonathan M., Yee, Jerry, Yesodharan, Gemini, Yeung, Jennifer, Yin, Chun H., Yip, Agustin G., Young, John Q., Young, Shane, Yu, Elizabeth An, Zenlea, Talia, Zha, B. Shoshana, Ziaie, Navid, Zipursky, Rachel, Zollman, Joshua W., Zorin, Danylo, and Zurek, Olivia

Published
2023
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15. A presentation of adenovirus with hypokalemia and rhabdomyolysis in pregnancy.

Author

Kishkovich, Thomas P, Lu, Connie F, Hardy, Erica J, and Russo, Melissa L

Subjects
BRADYCARDIA diagnosis, COMMUNICABLE disease diagnosis, HYPOMAGNESEMIA, RHABDOMYOLYSIS, COMMUNICABLE diseases, FEVER, DNA virus diseases, ADENOVIRUSES, VOMITING, PREGNANCY complications, HYPOKALEMIA, ABDOMINAL pain, CESAREAN section, SYMPTOMS, PREGNANCY, FETUS
Abstract

Background: Adenovirus infection is usually mild in presentation. However during pregnancy, the course can be more severe. Case: A 21-year-old woman in her second pregnancy presented with abdominal pain, vomiting, and fevers at 34 weeks and 4 days of gestation. Her respiratory pathogen panel on nasopharyngeal secretions was positive for adenovirus. Electrolytes were notable for hypomagnesaemia and persistent hypokalemia (nadir of 2.6 mmol/L) despite repletion but otherwise unremarkable. During her course, she developed rhabdomyolysis. During routine fetal monitoring at 35 weeks and 6 days of gestation, prolonged fetal bradycardia was identified, and an emergency caesarean delivery was performed. The infant had no clinical or laboratory evidence of adenovirus infection. The patient had a protracted clinical course but recovered with supportive care. Conclusion: Adenovirus can present with severe complications in a pregnant woman including hypokalemia and rhabdomyolysis. The mainstay of treatment is supportive care and monitoring of electrolyte abnormalities and renal function. [ABSTRACT FROM AUTHOR]

Published
2022
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18. Extragenital Infections Caused by Chlamydia trachomatis and Neisseria gonorrhoeae: A Review of the Literature.

Author

Chan, Philip A., Robinette, Ashley, Montgomery, Madeline, Almonte, Alexi, Cu-Uvin, Susan, Lonks, John R., Chapin, Kimberle C., Kojic, Erna M., and Hardy, Erica J.

Subjects
NEISSERIA gonorrhoeae, CHLAMYDIA trachomatis, GENITAL diseases, SEXUALLY transmitted diseases, PUBLIC health, MEDICAL economics, MEDICAL literature reviews, CHLAMYDIA infections, GONORRHEA, NEISSERIA, RESEARCH funding, HUMAN sexuality
Abstract

In the United States, sexually transmitted diseases due to Chlamydia trachomatis and Neisseria gonorrhoeae continue to be a major public health burden. Screening of extragenital sites including the oropharynx and rectum is an emerging practice based on recent studies highlighting the prevalence of infection at these sites. We reviewed studies reporting the prevalence of extragenital infections in women, men who have sex with men (MSM), and men who have sex only with women (MSW), including distribution by anatomical site. Among women, prevalence was found to be 0.6-35.8% for rectal gonorrhea (median reported prevalence 1.9%), 0-29.6% for pharyngeal gonorrhea (median 2.1%), 2.0-77.3% for rectal chlamydia (median 8.7%), and 0.2-3.2% for pharyngeal chlamydia (median 1.7%). Among MSM, prevalence was found to be 0.2-24.0% for rectal gonorrhea (median 5.9%), 0.5-16.5% for pharyngeal gonorrhea (median 4.6%), 2.1-23.0% for rectal chlamydia (median 8.9%), and 0-3.6% for pharyngeal chlamydia (median 1.7%). Among MSW, the prevalence was found to be 0-5.7% for rectal gonorrhea (median 3.4%), 0.4-15.5% for pharyngeal gonorrhea (median 2.2%), 0-11.8% for rectal chlamydia (median 7.7%), and 0-22.0% for pharyngeal chlamydia (median 1.6%). Extragenital infections are often asymptomatic and found in the absence of reported risk behaviors, such as receptive anal and oral intercourse. We discuss current clinical recommendations and future directions for research. [ABSTRACT FROM AUTHOR]

Published
2016
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19. Contributors

Author

Abdel-Razeq, Sonya S., Abdo, Tony, Abdulbaki, Abdulrahman, Abisse, Saddam Saleh, Adams, Cathleen, Afridi, Waffiyah, Agarwal, Megha, Ali, Tanya, Aliotta, Philip J., Alvero, Ruben, Anandan, Srividya, Anderson, Mel L., Anderson, Thomas J.T., Andolina, Laura M., Anilowski, Kathryn Taylor, Anthony, Anngene G., Anvar, Michelle S., Aoki, Etsuko, Armstrong, Grayson, Arshad, Rabia, Asfahani, Wissam S.Z., Ashkiani, Mohammad, Asiedu, Daniel K., Aulakh, Sudeep Kaur, Baliog, Crisostomo R., Jr., Bansal, Priya, BarrÉ, Luke, Barrett, Rowland P., Batra, Kerri, Berger, Omri, Berges, Arnaldo A., Bhagat, Vicky, Bhardwaj, Rahul, Biancuzzo, Rachael M., Bilodeau, Courtney Clark, Bishop, Kenneth D., Blundin, Michael, Bodkin, Sheenagh M., Bora, Nirali, Borkan, Jeffrey M., Boske, Alexandra, Bowlby, Lynn, Brady, Mark F., Brar, Mandeep K., Brennan, Keith, Brown, Elizabeth J., Brown, Gavin, Buckley, Jennifer, Burns, Jonathan, Burtis, D. Brandon, Burtt, Douglas, Busselen, Steven, Butler, Robert, Cabrera, Claudia Rodriguez, Caraganis, Andrew, Cerezo, Carolina S., Chalkley, Joshua, Chan, Philip A., Chatterjee, Saurav, Chaudhry, Sunit-Preet, Cheng, Vicky, Chisholm, Sarah L., Chudasama, Neelesh Lalji, Clarke, Jonathan P., Cohen, Lisa, Compton, Kaila, Corwin, Jessica, Cowles, Brian J., Cristescu, Dan A., Cristofaro, Patricia, Cunha, Joanne Szcygiel, Curry, Stephanie A., Curtin, Alicia J., D’avanzato, Catherine, Dahhan, Ali, Dalrymple, Kristy L., Danakas, George T., Degenhardt, Alexandra, Diaz, Joseph A., Dobbs, Michael R., Doobay, Nathalia, Doran, Amanda C., Dotson, William F., II, Duker, Andrew, Eisendrath, Stuart J., Eisenhower, Christine, Ellsworth, Pamela, Engels, Michael, Espinosa, Patricio Sebastian, Fabre, Valeria, Fagan, Mark J., Farrell, Timothy W., Ferri, Fred F., Ferri, Heather, Fine, Antonella, Fine, Barry, Finney, Glen, Fischer, Staci A., Fong, Tamara G., Fontenot Ferriss, Amber N., Forcier, Michelle, Fort, Frank G., Fort, Glenn G., Fortunato, David J., Franco, Kyle, Fraser, Justin F., Gaddam, Sainath, Gallo, Anthony, Garas, Marina, Garbus, Leanna R., George, Paul F., Ghosh, Joydeep, Gleit, Cindy, Goldberg, Richard J., Goldburt, Alla, Gopalakrishnan, Geetha, Gordon, Paul, Graff, Nancy R., Gray, John A., Groves, Elliott M., Grupke, Stephen L., Gultawatvichai, Patan, Gupta, Priya Sarin, Hack, Nawaz, Hall, Harald A., Han, Leo, Handa, Sajeev, Hardy, Erica J., Harrison, Taylor, Hayes, Don, Jr., Hoffman, R. Scott, Hogan, Dawn, Holland, N. Wilson, Hu, Susie L., Hume, Anne L., Waller Hutson, Sharlisa, Isaacson, Richard S., Ismail, Ahmad M., Jantz, Jennifer, Javier, Noel S.C., Jeremiah, Jennifer, Johnson, Michael P., Jones, Kimberly, Kalanithi, Lucy, Kapoor, Siddharth, Kassakian, Claire, Katz, Emily R., Kazim, Ali, Kedar, Sachin, Keeley, Brooke E., Kenney, Bevin, Kim, Byung, Kim, Jin Kyung, Kim, Wan J., Kirchner, Robert M., Koby, Melvyn, Kohn, Robert, Kokkirala, Aravind Rao, Kramer, Kristina, Krishnamohan, Prashanth, Kumaraiah, Deepa, Kurss, David I., Lai, Cindy, Lally, Edward V., Rizwan Latif, Syde, Le, Quang P., Lee, Kachiu, Levchenko, Andre, Lightner, Donita Dillon, Long, Richard, Lowenhaupt, Elizabeth A., Lundholm, Amy L., Magee, Susanna R., Maher, Michael, Majczak, Marta, Al Malki, Monzr M., Mansoor, Atizazul H., Marsh, Michael A., Matson, Elisabeth B., Mavrich, Kate, May, Lauren, May, Alison C., Mazumdar, Maitreyi, Mbuyi, Nadine, Mcculloh, Russell J., McGarry, Kelly A., McNicoll, Lynn, Medlin, Erin, Mehta, Akanksha, Mendez-Allwood, Daniel E., Menendez, Alvaro, Mercier, Lonnie R., Merla, Veeranna, Mnhas, Hassan, Mohammed, Nadeem, Morgan, Theresa A., Mujahid, Nadia, Elias Najem, Catherine, Naqvi, Bilal H., Nasir, Uzma, Nee, Judy, Nemoto, Takuma, Nothnagle, Melissa, Nsereko, Patrick, O’Brien, Gail M., Olawaiye, Alexander B., Ong, Michael K., Opal, Steven M., Orchowski, Lindsay M., Owens, Joseph R., Oza, Amar, Pace, Paolo G., Pacheco, Cristina Antonio, Pappas-Taffer, Lisa, Patel, Aleema, Patel, Birju B., Patel, Hemali, Patel, Pranav M., Patrozou, Eleni, Patterson, Alison, Peligian, Steven, Perera, Pranith, Perez, Kimberly, Phillips, Katharine A., Pirraglia, Paul A., Plante, Wendy A., Plumley, Kevin, Hartman Polensek, Sharon S., Poon, Samuel H., Posner, Donn, Prasad, Arundathi G., Pressman, Amanda, Prodromou, Michael, Promrat, Kittichai, Punjani, Shahnaz, Quesenberry, Matthew I., Radlinski, Heidi, Ramanan, Radhika A., Rao, Shaline D., Rashid, Wasim, Raukar, Neha P., Reagan, John L., Regnante, Richard, Reus, Victor I., Rich, Harlan G., Richards, Rocco J., Roach, Rachel, Robinson, Luther K., Roda, Dominic, Rogers, Jamison, Rolle, Anishka S., Roth, Julie L., Roth, Lauren, Rubeor, Amity, Ruisi, Phillip, Sadiq, Immad, Sahni, Gagan, Said, Nuha R., Satpathy, Hemant K., Satpathy, Ruby K., Satterfield, Jason M., Savoie, Brian, Sayeed, Syeda M., Scarmangas-Plumley, Daphne, Sell, Peter J., Serrano-Gomez, Claudia, Shafts, Catherine, Shih, Grace, Shrestha, Asha, Sigman, Mark, Silvia, Joanne M., Singhal, Divya, Skalecki, Jon, Sladky, John, Smith, Jeanette G., Sohur, U. 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Published
2015
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20. Testing and Treatment After Non-Occupational Exposures To STDs and HIV.

Author

Hardy, Erica J.

Subjects
*SEXUALLY transmitted disease diagnosis, *DIAGNOSIS of HIV infections, *SEXUALLY transmitted disease treatment, *HIV infections, *THERAPEUTICS, *MEDICAL care of HIV-positive persons, *AIDS patients, *CHLAMYDIA, *GONORRHEA, *TRICHOMONAS, *MEDICAL care
Abstract

The article discusses the new recommendations for the prophylaxis, testing, and treatment of adult patients after non-occupational exposures to sexually transmitted disease (STD) and human immunodeficiency virus (HIV). It states that enough time may not have elapsed for a STD test to be positive depending on the time from exposure to presentation for medical care. It says that empiric treatment rather than testing is recommended by most experts. It mentions the regimens recommended for empiric treatment including one for Chlamydia, Gonorrhea, and Trichomonas.

Published
2012

21. Association Between Hispanic Ethnicity and Engagement in a Remote Postpartum Blood Pressure Monitoring Programs: Secondary Analysis of a Pilot Randomized Trial.

Author

LEWKOWITZ, ADAM K., SCHLICHTING, LAUREN E., AYALA, NINA K., O'NEILL, AMANDA, McCLEARY, KATHERINE D., HARDY, ERICA J., HAMEL, MAUREEN, and TUULI, METHODIUS G.

Subjects
*BLOOD pressure, *SECONDARY analysis, *PATIENT portals, *AMBULATORY blood pressure monitoring, *PUERPERIUM, *ETHNICITY, *POSTPARTUM contraception
Abstract

OBJECTIVE: Remote self-measured blood pressure (SMBP) programs improve racial health equity among postpartum people with hypertensive disorders of pregnancy (HDP) who receive recommended blood pressure ascertainment after hospital discharge. However, as prior studies have been conducted within racially diverse but ethnically homogeneous populations, the effect of SMBP programs on ethnicity-based inequities is less understood. We examined whether SMBP rates differed among Hispanic versus non-Hispanic participants in remote SMBP programs. STUDY DESIGN: This is a planned secondary analysis of a RCT conducted among postpartum patients with HDP who were enrolled into our remote SMBP program, in which they obtain SMBP and then manually enter the SMBP value into a patient portal for individual provider response. In the parent trial, consenting patients were randomized to continued manual blood pressure entry of SMBP or use of a Bluetooth-enabled blood pressure cuff synched to a smartphone application utilizing artificial intelligence to respond to each obtained blood pressure or symptom for six weeks and to flag abnormalities for providers. Both SMBP programs were available in Spanish and English. For this study, women who self-reported their ethnicity were stratified into two ethnic groups - Hispanic and non-Hispanic - regardless of randomization group. Those who did not self-report ethnicity but completed all study procedures in Spanish were also categorized as Hispanic. Outcomes were the same in the parent study and this secondary analysis. The primary outcome was ≥1 SMBP assessment within 10 days postpartum. Secondary outcomes included number of blood pressure assessments and healthcare utilization outcomes (remote antihypertensive medication initiation or dose-in-crease and presentation to the Emergency Department or readmission for hypertension within 30 days of discharge). Participants rated their experience with SMBP via a scale from 0 (worst possible) to 10 (best possible) and the Decision Regret Scale, which assessed their regret in SMBP program participation (0=no regret; 100=high regret)). Outcomes were compared between groups. Risk differences (RD) were calculated for categorical and regression coefficients for continuous outcomes. The parent RCT was IRB-approved and published on clinical-trials.gov (NCT05595629) before enrollment. RESULTS: Among 119 women in the parent study, 83 (70%) self-reported ethnicity and the proportion of Hispanic people was similar in both treatment groups. This study compared 23 Hispanic (19% monolingual in Spanish) to 62 non-Hispanic women. Rates of SMBP assessment within 10 days postpartum was similar (Hispanic 64% vs non-Hispanic 79%; RD -0.1 (95% Confidence Interval (CI) -0.4, 0.1). There were no differences in mean number of remote SMBP assessments or rates of remote antihypertensive medication initiation or dose titration. The rates of hypertension-related presentations to the Emergency Department or hospital readmission were also similar between groups. Lastly, regardless of ethnicity, participants had low scores on the Decision Regret Scale and rated their experience with their remote SMBP program highly favorably. (See Table 1.) CONCLUSION: Hispanic and non-Hispanic postpartum patients with HDP had similar outcomes and favorable patient perceptions. The small sample size in this study may have produced inadequate power to detect a difference between study groups, thereby leading to Type II error. Thus, more research on Hispanic participants in remote SMBP programs is needed. However, the effect of remote SMBP programs on perinatal equity may not be limited to race-based disparities. [ABSTRACT FROM AUTHOR]

Published
2024

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