Search

Your search keyword '"Hardisty R"' showing total 412 results
Start Over Author "Hardisty R"
412 results on '"Hardisty R"'

2. Why Do Old Men Have Big Ears?

Author

Khaw, Kay-Tee, Woo, Pick-Ngor, Lip, Peck-Lin, Asai, Yasuhiro, Yoshimura, Manabu, Nago, Naoki, Yamada, Takashi, and Hardisty, R. M.

Published
1996

27. Active Immunotherapy in the Treatment of Leukemia and Other Malignant Diseases in Animals and Man

Author

Fairley, G. Hamilton, Crowther, D., Guyer, J. G., Hardisty, R. M., Kay, H. E. M., Knapton, P. J., McElwain, T. J., Parr, I. B., Allfrey, V. G., editor, Allgöwer, M., editor, Bauer, K. H., editor, Berenblum, I., editor, Bergel, F., editor, Bernard, J., editor, Bernhard, W., editor, Blokhin, N. N., editor, Bock, H. E., editor, Bucalossi, P., editor, Chaklin, A. V., editor, Chorazy, M., editor, Cunningham, G. J., editor, Dameshek, W., editor, Dargent, M., editor, Porta, G. Della, editor, Denoix, P., editor, Dulbecco, R., editor, Eagle, H., editor, Eker, R., editor, Grabar, P., editor, Hamperl, H., editor, Harris, R. J. C., editor, Hecker, E., editor, Herbeuval, R., editor, Higginson, J., editor, Hueper, W. C., editor, Isliker, H., editor, Karnofsky, D. A., editor, Kieler, J., editor, Klein, G., editor, Koprowski, H., editor, Koss, L. G., editor, Martz, G., editor, Mathé, G., editor, Mühlbock, O., editor, Nakahara, W., editor, Potter, V. R., editor, Sabin, A. B., editor, Sachs, L., editor, Saxén, E. A., editor, Szybalski, W., editor, Tagnon, H., editor, Taylor, R. M., editor, Tissières, A., editor, Uehlinger, E., editor, Wissler, R. W., editor, Yoshida, T., editor, Rentchnick, P., editor, and Mathé, Georges, editor

Published
1970
Full Text
View/download PDF

28. Use of Asparaginase in Conjunction with Cytosine Arabinoside in Acute Leukemia in Children

Author

Hardisty, R. M., McElwain, T. J., Allfrey, V. G., editor, Allgöwer, M., editor, Bauer, K. H., editor, Berenblum, I., editor, Bergel, F., editor, Bernard, J., editor, Bernhard, W., editor, Blokhin, N. N., editor, Bock, H. E., editor, Bucalossi, P., editor, Chaklin, A. V., editor, Chorazy, M., editor, Cunningham, G. J., editor, Dameshek, W., editor, Dargent, M., editor, Della Porta, G., editor, Denoix, P., editor, Dulbecco, R., editor, Eagle, H., editor, Eker, R., editor, Grabar, P., editor, Hamperl, H., editor, Harris, R. J. C., editor, Hecker, E., editor, Herbeuval, R., editor, Higginson, J., editor, Hueper, W. C., editor, Isliker, H., editor, Karnofsky, D. A., editor, Kieler, J., editor, Klein, G., editor, Koprowski, H., editor, Koss, L. G., editor, Martz, G., editor, Mathé, G., editor, Mühlbock, O., editor, Nakahara, W., editor, Potter, V. R., editor, Sabin, A. B., editor, Sachs, L., editor, Saxén, E. A., editor, Spiegelmann, S., editor, Szybalski, W., editor, Tagnon, H., editor, Taylor, R. M., editor, Tissières, A., editor, Uehlinger, E., editor, Wissler, R. W., editor, Yoshida, T., editor, Rentchnick, P., editor, Grundmann, E., editor, and Oettgen, H. F., editor

Published
1970
Full Text
View/download PDF

32. Myosin VIIA is specifically associated with calmodulin and microtubule-associated protein-2B (MAP-2B)

Author

Todorov, P T, Hardisty, R E, and Brown, S D

Subjects
Molecular Sequence Data, macromolecular substances, Myosins, Ligands, Chromatography, Affinity, Mice, Structure-Activity Relationship, Calmodulin, Antibody Specificity, otorhinolaryngologic diseases, Animals, Amino Acid Sequence, Cells, Cultured, Binding Sites, Dyneins, Immunohistochemistry, eye diseases, Molecular Weight, Myosin VIIa, Luminescent Measurements, sense organs, Rabbits, Microtubule-Associated Proteins, circulatory and respiratory physiology, Research Article, Protein Binding
Abstract

Myosin VIIA is a motor molecule with a conserved head domain and tail region unique to myosin VIIA, which probably defines its unique function in vivo. In an attempt to further characterize myosin VIIA function we set out to identify molecule(s) that specifically associate with it. We demonstrate that 17 and 55 kDa proteins from mouse kidney and cochlea co-purify with myosin VIIA on affinity columns carrying immobilized anti-myosin VIIA antibody. N-terminal sequencing and immunoblotting analysis identified the 17 kDa protein as calmodulin, whereas MS and immunoblotting analysis identified the 55 kDa protein as microtubule-associated protein-2B (MAP-2B). Myosin VIIA can also be co-immunoprecipitated from kidney homogenate using anti-calmodulin or anti-MAP2 (recognizing isoforms 2A and 2B) antibodies, confirming the strong association between calmodulin and myosin VIIA and between MAP-2B and myosin VIIA. Myosin VIIA binds to calmodulin with an apparent K(d) of 10(-9) M. Scatchard analysis of the binding of myosin VIIA to MAP-2B provided evidence for two binding sites, with K(d) values of 10(-10) and 10(-9) M, which have been mapped to medial and C-terminal tail domains of myosin VIIA. The characterization of the interaction of calmodulin and MAP-2B with myosin VIIA provides new insights into the function of myosin VIIA.

Published
2001

Catalog

Books, media, physical & digital resources
See catalog results