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7. Effect of pulsatile growth hormone administration to the growth-restricted fetal sheep on somatotrophic axis gene expression in fetal and placental tissues

Author

Bloomfield, F.H., van Zijl, P.L., Bauer, M.K., Phua, H.H., and Harding, J.E.

Subjects
Sheep -- Physiological aspects, Gene expression -- Research, Placental hormones -- Health aspects, Fetus -- Growth, Fetus -- Research, Biological sciences
Abstract

We have previously reported (Bauer MK, Breier BH, Bloomfield FH, Jensen EC, Gluckman PD, and Harding JE. J Endocrinol 177: 83-92, 2003) that a chronic pulsatile infusion of growth hormone (GH) to intrauterine growth-restricted (IUGR) ovine fetuses increased fetal circulating IGF-I levels without increasing fetal growth. We hypothesized a cortisol-induced upregulation of fetal hepatic GH receptor (GH-R) mRNA levels, secondary increases in IGF-I mRNA levels, and circulating IGF-I levels, but a downregulation of the type I IGF receptor (IGF-IR) as an explanation. We, therefore, measured mRNA levels of genes of the somatotrophic axis by real-time RT-PCR in fetal and placental tissues of fetuses with IUGR (induced by uteroplacental embolization from 110- to 116-days gestation) that received either a pulsatile infusion of GH (total dose 3.5 mg/day) or vehicle from 117-126 days and in control fetuses (n = 5 per group). Tissues were collected at 127 days (term, 145 days). Fetal cortisol concentrations were significantly increased in IUGR fetuses. However, in liver, GH-R, but not IGF-I or IGF-IR, mRNA levels were decreased in both IUGR groups. In contrast, in placenta, GH-R, IGF-I, and IGF-IR expression were increased in IUGR vehicle-infused fetuses. GH infusion further increased placental GH-R and IGF-IR, but abolished the increase in IGF-I mRNA levels. GH infusion reduced IGF-I expression in muscle and increased GH-R but decreased IGF-IR expression in kidney. IUGR increased hepatic IGF-binding protein (IGFBP)-1 and placental IGFBP-2 and -3 mRNA levels with no further effect of GH infusion. In conclusion, the modest increases in circulating cortisol concentrations in IUGR fetuses did not increase hepatic GH-R mRNA expression and, therefore, do not explain the increased circulating IGF-I levels that we found with GH infusion, which are likely due to reduced clearance rather than increased production. We demonstrate tissue-specific regulation of the somatotrophic axis in IUGR fetuses and a discontinuity between GH-R and IGF-I gene expression in GH-infused fetuses that is not explained by alterations in phosphorylated STAT5b. fetal therapy; intrauterine growth restriction doi:10.1152/ajpendo.00045.2006

Published
2006

10. Long term effects of antenatal betamethasone on lung function: 30 year follow up of a randomised controlled trial

Author

Dalziel, S.R., Rea, H.H., Walker, N.K., Parag, V., Mantell, C., Rodgers, A., and Harding, J.E.

Subjects
Betamethasone -- Dosage and administration, Betamethasone -- Patient outcomes, Betamethasone -- Research, Prenatal drug exposure -- Patient outcomes, Prenatal drug exposure -- Research, Pulmonary function tests -- Analysis, Respiratory distress syndrome -- Prevention, Health
Published
2006

11. The late effects of fetal growth patterns

Author

Bloomfield, F.H., Oliver, M.H., and Harding, J.E.

Subjects
Birth size -- Physiological aspects, Birth weight -- Physiological aspects, Pregnant women -- Food and nutrition, Pregnancy -- Health aspects, Fetus -- Growth, Fetus -- Physiological aspects, Family and marriage, Health, Women's issues/gender studies
Published
2006

12. Exposure to repeat doses of antenatal glucocorticoids is associated with altered cardiovascular status after birth

Author

Mildenhall, L.F.J., Battin, M.R., Morton, S.M.B., Bevan, C., Kuschel, C.A., and Harding, J.E.

Subjects
Prenatal drug exposure -- Research, Corticosteroids -- Dosage and administration, Corticosteroids -- Research, Cardiovascular system -- Research, Infants (Newborn) -- Physiological aspects, Infants (Newborn) -- Research, Family and marriage, Health, Women's issues/gender studies
Published
2006

14. Does variation in interpretation of ultrasonograms account for the variation in incidence of germinal matrix/intraventricular haemorrhage between newborn intensive care units in New Zealand?

Author

Harris, D.L., Teele, R.L., Bloomfield, F.H., and Harding, J.E.

Subjects
Diagnosis, Ultrasonic -- Evaluation, Hemorrhagic disease of newborn -- Research, Intraventricular hemorrhage -- Diagnosis, Intraventricular hemorrhage -- Risk factors, Family and marriage, Health, Women's issues/gender studies
Published
2005

15. Fetal nutrition and cardiovascular disease in adult life

Author

Barker, D.J.P., Gluckman, P.D., Godfrey, K.M., Harding, J.E., Owens, J.A., and Robinson, J.S.

Subjects
Fetal malnutrition -- Physiological aspects, Cardiovascular diseases -- Risk factors, Birth weight, Low -- Physiological aspects, Diabetes -- Risk factors
Published
1993

16. Follow up of a randomised trial of two different courses of dexamethasone for preterm babies at risk of chronic lung disease. (Original Article)

Author

Armstrong, D.L., Penrice, J., Bloomfield, F.H., Knight, D.B., Dezoete, J.A., and Harding, J.E.

Subjects
Dexamethasone -- Evaluation -- Health aspects, Pediatric respiratory diseases -- Drug therapy -- Health aspects, Infants (Premature) -- Health aspects -- Drug therapy, Family and marriage, Health, Women's issues/gender studies, Drug therapy, Evaluation, Health aspects
Abstract

Objectives: To report 18 month outcome of a randomised trial of two courses of dexamethasone to prevent chronic lung disease of prematurity. Study design: Babies of birth weight 1250 g [...]

Published
2002

17. Contributors

Author

Abbasi, Soraya, Afshar, Yalda, Ahn, Sun-Young, Albertine, Kurt H., Allegaert, Karel, Alper, Seth L., Altit, Gabriel, Alvaro, Ruben E., Alvira, Cristina M., Maia Amorim, Natália Carlos, Anbuhl, Kelsey L., Andersen, Claus Yding, Anderson, Richard A., Andrews, Katrina A., Askenazi, David J., Fernandes Assunção, Débora Gabriela, Auten, Richard Lambert, Jr., Autmizguine, Julie, Azhibekov, Timur, Back, Stephen A., Bahr, Timothy M., Baker, Peter Russell, II, Bancalari, Eduardo H., Barichello, Tatiana, Battaglia, Frederick C., Bauer, Andrew J., Baum, Michel, Bavis, Ryan W., Beardsall, Kathryn, Beggs, Simon, Benchimol, Corinne, Benders, Manon J.N.L., Bennet, Laura, Bennett, Phillip R., Berger, Melvin, Bernhard, Wolfgang, Bertram, John F., Bhombal, Shazia, Bhutani, Vinod K., Black, Mary Jane, Bliss, Joseph M., Bolender, David L., Bowdin, Sarah C., Boyd, Scott D., Brandenburg, Joline E., Brown, Laura D., Burrin, Douglas G., Cannon, Barbara, Caplan, Michael, Carlson, Susan E., Carlton, David P., Chaemsaithong, Piya, Chang, Jill, Charlton, Jennifer R., Chemtob, Sylvain, Chheda, Sadhana, Childs, Andrew J., Chu, David H., Chung, Wendy K., Cilio, Maria Roberta, Clark, David A., Clarke, Paul, Cleal, Jane K., Clemente, Ethel G., Clements, John A., Clyman, Ronald I., Cohen, Jennifer L., Cohen, Susan S., Collins, Amélie, Collodel, Allan, Colombo, John, Combes, Alexander N., Copp, Andrew J., Cotten, C. Michael, Crawford, Peter A., Crowe, James E., Jr., Crowther, C.A., Cullen-McEwen, Luise A., Cutfield, Wayne S., Cyr-Depauw, Chanèle, Danielly da S. Ribeiro, Karla, Dauby, Nicolas, Davenport, Patricia, Davidson, Joanne O., Cruz, Diomel de la, Gomes de Oliveira, Priscila, de Vrijer, Barbra, Del Colle, Andrew, Delacourt, Christophe, Diacovo, Thomas G., Disdier, Clémence, Dormans, John P., Duhamel, François, Duong, Minh Dien, Dysart, Kevin, Eichenwald, Eric C., El-Khuffash, Afif F., Ivor Ellis, Peter James, Empey, Kerry M., Ercal, Baris, Erdős, Melinda, Errede, Mariella, Feldman, Brian J., Fidanza, Mario, Fogarty, Matthew J., Friedlich, Philippe S., Fujiwara, Ryoichi, Gallo, Vittorio, Ganguly, Abhrajit, Gao, Yuansheng, Garland, Marianne, Geddes, Donna, Dip (Sci), Post Grad, Georgieff, Michael K., Gien, Jason, Giussani, Dino A., Goldman, Armond S., Gomez-Lopez, Nardhy, Good, Misty, Good, Pamela I., Gordon, Scott M., Green, Lucy R., Greene, Nicholas D.E., Gridneva, Zoya, Grigoriou, Emmanouil, Grimberg, Adda, Grunau, Ruth E., Guignard, Jean-Pierre, Gunn, Alistair J., Gurtunca, Nursen, Gustafson, Kathleen M., Hadchouel, Alice, Haddad, Gabriel G., Hale, Thomas W., Hambidge, K. Michael, Hammerman, Cathy, Ruud Hansen, Thor Willy, Hanson, Mark A., Harbeson, Danny, Harding, J.E., Harding, Richard, Harris, Mary Catherine, Hartmann, Peter, Hartnett, M. Elizabeth, Hasbun, Rodrigo, Haugen, Guttorm, Hawkes, Colin P., Hay, William W., Jr., Heine, Vivi M., Helmrath, Michael A., Hendricks-Muñoz, Karen D., Herrera, Emilio, Hiatt, Michael J., Hooper, Stuart B., Hooven, Thomas A., Iacobelli, Silvia, Inder, Terrie E., Iruela-Arispe, M. Luisa, Jadcherla, Sudarshan Rao, Jain, Deepak, Jetton, Jennifer G., Jobe, Alan H., Jones, Helen, Jose, Pedro A., Jung, Eunjung, Kallapur, Suhas G., Kaplan, Michael, Karumanchi, S. Ananth, Kaskel, Frederick J., Levitt Katz, Lorraine E., Kavus, Haluk, Keeney, Susan E., Kern, Steven E., Khanjani, Shirin, Khlevner, Julie, Kilpatrick, Laurie E., Kim, Chang-Ryul, Kingma, Paul S., Kinsella, John P., Kiserud, Torvid, Koenig, Joyce M., Kohli, Rohit, Kollmann, Tobias R., Kolls, Jay K., Konecny, Christina M., Kratimenos, Panagiotis, Krebs, Nancy F., Krutsch, Kaytlin, Kuhn-Riordon, Kara, Kulik, Thomas J., Kumar, T. Rajendra, Kutikov, Jessica Katz, Lakshminrusimha, Satyan, Lasunción, Miguel Angel, Lavoie, Pascal M., Lawrence, Shelley M., Lee, Mark K., Lee, Mary M., Lee, Yvonne K., Leibel, Sandra L., Levy, Ofer, Levy, Philip T., Lewis, Rohan M., Li, Changgong, Lin, Fangming, Lobritto, Steven, Loomis, Cynthia A., MacFarlane, Peter M., MacIntyre, David A., Mahe, Maxime M., Mamsen, Linn Salto, Mankouski, Anastasiya, Mantilla, Carlos B., Marchant, Arnaud, Margolis, Kara Gross, Maródi, László, Maršál, Karel, Martin, Richard J., Martin Carli, Jayne F., Martinez, Hugo R., Matsell, Douglas G., Matthews, Dwight E., McArdle, Harry J., McKinlay, C.J.D., McManaman, James L., McNamara, Patrick J., Meschia, Giacomo, Mestan, Karen, Miller, Steven P., Minoo, Parviz, Mir, Imran N., Mitchell, Lisa J., Mižíková, Ivana, Mizuno, Tomoyuki, Momper, Jeremiah D., Monagle, Paul, Monks, Jenifer, Mortola, Jacopo P., Muglia, Louis J., Munshi, Upender K., Narasimhan, Sumana, Narendran, Vivek, Nedergaard, Jan, Nelin, Leif D., Neu, Josef, Nielsen, Sandra C.A., Nigam, Sanjay K., Nizet, Victor, Nogee, Lawrence M., Noori, Shahab, Norris, Andrew W., O’Brien, Barbara M., O’Brien, Lori L., O’Callaghan, Karen M., Ogilvy-Stuart, Amanda, Ohls, Robin K., Ortega-Senovilla, Henar, O’Sullivan, Justin M., Panitch, Howard B., Penn, Anna A., Penn, Raymond B., Petroff, Margaret G., Philipps, Anthony F., Pisani, Francesco, Pleasure, David, Pomeroy, Scott L., Post, Martin, Prakash, Y.S., Prozialeck, Joshua D., Pysher, Theodore J., Quigley, Raymond, Rabinovitch, Marlene, Raffay, Thomas M., Raj, J. Usha, Ramsey, Laura B., Rana, Sarosh, Randis, Tara M., Ranger, Manon, Regnault, Timothy R.H., Rios, Danielle R., Romero, Roberto, Rosenfeld, Charles R., Ross, A. Catharine, Roth, Daniel E., Rozycki, Henry J., Ryan, Thomas D., Sahni, Rakesh, Sarnat, Harvey B., Satlin, Lisa M., Scafidi, Joseph, Schellpfeffer, Michael A., Schierding, William, Schwartz, George J., Segar, Jeffrey L., Selewski, David T., Seri, Istvan, Shaffer, Thomas H., Shearer, Martin J., Shroyer, Noah F., Sieck, Gary C., Simmons, Rebecca A., Singh, Neel Kamal, Sivieri, Emidio, Smith, Laura, Smyth, Ian M., Sola-Visner, Martha C., Solhaug, Michael J., Sperandio, Markus, Sperling, Mark A., Srinivasan, Lakshmi, Stanescu, Diana E., Stanley, Charles A., Steinhorn, Robin H., Stinson, Lisa, Stonestreet, Barbara S., Strasburger, Janette F., Styne, Dennis M., Sun, Xin, Sussel, Lori, Tam, Emily W.Y., Tan, Libo, te Pas, Arjan B., Ten, Vadim S., Thébaud, Bernard, Thornton, Claire, Tollin, Daniel J., Towbin, Jeffrey A., Truog, William E., III, Uhler, Kristin M., van den Akker, Chris H.P., Nicolaas van den Anker, John, van den Hoff, Maurice J.B., van Goudoever, Johannes (Hans) B., Vickers, Mark H., Vinks, Alexander A., Virgintino, Daniela, Visscher, Marty O., Vonderohe, Caitlin E., Vyas, Neha V., Wacker-Gussmann, Annette, Walch, Abby, Wallace, Megan J., Walsh, Brian H., Wambach, Jennifer A., Wang, Linda X., Warburton, David, Ward, Robert M., Watt, Kevin M., Watterberg, Kristi L., Werner, Lynne A., Wernimont, Sarah A., Wershil, Barry K., Wessels, Andy, Whitsett, Jeffrey A., Willems, Fabienne, Win, Myat Su, Wohlmuth, Christoph, Wolf, Matthias T., Wolfson, Marla R., Wong, Ronald J., Wynn, James L., Yeo, Lami, Yoder, Bradley A., Yuskaitis, Christopher J., Zabinsky, Jennifer, and Zhou, Dan

Published
2022
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21. Does radio-opaque contrast improve radiographic localisation of percutaneous central venous lines?

Author

Odd, D.E., Page, B., Battin, M.R., and Harding, J.E.

Subjects
Intravenous catheterization -- Management -- Usage -- Methods, Pediatric radiology -- Methods -- Usage, Family and marriage, Health, Women's issues/gender studies, Company business management, Management, Usage, Methods
Abstract

Arch Dis Child Fetal Neonatal Ed 2004;89:F41-F43 Background: Percutaneous central venous lines (long lines) are commonly used in neonatal practice. The position of these lines is important, because incorrect placement [...]

Published
2004

24. Measurement of the subarachnoid space by ultrasound in preterm infants. (Original Article)

Author

Armstrong, D.L., Bagnall, C., Harding, J.E., and Teele, R.L.

Subjects
Brain, Infants -- Development, Infants (Premature) -- Medical examination, Family and marriage, Health, Women's issues/gender studies, Medical examination
Abstract

Background: Measurements of the subarachnoid space during routine cranial sonography may provide an indirect method of monitoring brain growth in preterm infants. Methods: The width of the subarachnoid space was [...]

Published
2002

26. Bridge Management

Author

Harding, J.E., Green, Jeffrey, Harding, J.E., Harding, J.E., Green, Jeffrey, and Harding, J.E.

Abstract

This volume consists of papers presented at the First International Conference on Bridge Management, held at The University of Surrey, Guildford, UK, from 28-30 March 1990.

Published
1990

44. Fetal growth and placental function

Author

Bauer, M.K, primary, Harding, J.E, additional, Bassett, N.S, additional, Breier, B.H, additional, Oliver, M.H, additional, Gallaher, B.H, additional, Evans, P.C, additional, Woodall, S.M, additional, and Gluckman, P.D, additional

Published
1998
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