28 results on '"Hardenberg, Jost von"'
Search Results
2. Monoprophylaxis with cephalosporins for transrectal prostate biopsy after the fluoroquinolone-era: a multi-institutional comparison of severe infectious complications
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Wenzel, Mike, Hardenberg, Jost von, Welte, Maria-Noemi, Doryumu, Samuel, Höh, Robert Benedikt, Wittler, Clarissa, Höfner, Thomas, Kriegmair, Maximilian, Michel, Maurice Stephan, Chun, Felix, Herrmann, Jonas, Mandel, Philipp, and Westhoff, Niklas Christian
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ddc:610 - Abstract
Background: To compare severe infectious complication rates after transrectal prostate biopsies between cephalosporins and fluoroquinolones for antibiotic monoprophylaxis. Material and Methods: In the multi-institutional cohort, between November 2014 and July 2020 patients received either cefotaxime (single dose intravenously), cefpodoxime (multiple doses orally) or fluoroquinolones (multiple-doses orally or single dose intravenously) for transrectal prostate biopsy prophylaxis. Data were prospectively acquired and retrospectively analyzed. Severe infectious complications were evaluated within 30 days after biopsy. Logistic regression models predicted biopsy-related infectious complications according to antibiotic prophylaxis, application type and patient- and procedure-related risk factors. Results: Of 793 patients, 132 (16.6%) received a single dose of intravenous cefotaxime and were compared to 119 (15%) who received multiple doses of oral cefpodoxime and 542 (68.3%) who received fluoroquinolones as monoprophylaxis. The overall incidence of severe infectious complications was 1.0% (n=8). No significant differences were observed between the three compared groups (0.8% vs. 0.8% vs. 1.1%, p=0.9). The overall rate of urosepsis was 0.3% and did not significantly differ between the three compared groups as well. Conclusion: Monoprophylaxis with third generation cephalosporins was efficient in preventing severe infectious complications after prostate biopsy. Single intravenous dose of cefotaxime and multiday regimen of oral cefpodoxime showed a low incidence of infectious complications
- Published
- 2021
3. On the use of IASI spectrally resolved radiances to test the EC-Earth climate model (v3.3.3) in clear-sky conditions.
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Fera, Stefano Della, Fabiano, Federico, Raspollini, Piera, Ridolfi, Marco, Cortesi, Ugo, Barbara, Flavio, and Hardenberg, Jost von
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GENERAL circulation model ,HYPERSPECTRAL imaging systems ,SEA surface positioning ,WEATHER ,TERRESTRIAL radiation - Abstract
The long-term comparison between simulated and observed spectrally resolved radiances can represent a stringent test for the direct verification and improvement of General Circulation Models (GCMs). From the mid of 2000s, stable hyperspectral observations of the Mid-Infrared region (667 to 2750 cm
-1 ) the Earth emission spectrum have been provided by different sensors (e.g., AIRS, IASI and CrIS). In addition, the FORUM mission, selected to be the ninth ESA Earth Explorer mission, will measure, starting from 2027, the terrestrial radiation emitted to space at the top of the atmosphere (TOA) from 100 to 1600 cm-1 filling the observational gap in the far-infrared (FIR) region, from 100 to 667 cm-1 . In this work, in anticipation of FORUM measurements, we compare existing IASI observations to radiances simulated on the basis of the atmospheric fields predicted by the EC-Earth GCM (version 3.3.3) in clear-sky conditions. In order to simulate spectra based on the atmospheric and surface state provided by the climate model, the radiative transfer model σ -IASI has been implemented in the Cloud Feedback Model Intercomparison Project (COSP) package. Therefore, on-line simulations provided by EC-Earth model equipped with the new COSP + σ -IASI module have been performed in clear-sky conditions with prescribed sea surface temperature and sea-ice cover, every 6 hours, over a timeframe consistent with the availability of IASI data. Systematic comparisons between observed IASI MetOp-A L1C data and model outputs have been performed in 10 cm-1 spectral intervals, on global and regional scales, by distinguishing the surface type (land, sea). The long term analysis shows a warm bias of the climate model in the roto-vibrational water vapour bands and in the CO2 absorption band. These biases represent a strong evidence of a temperature bias of the model in the upper-troposphere and in the stratosphere, while a cold bias occurs over land. [ABSTRACT FROM AUTHOR]- Published
- 2022
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4. Local and Regional Wind Patterns Affect Spring Migration Magnitude, Flyways and Flocking Of European Honey-Buzzards Pernis apivorus at the Strait of Messina
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Agostini, Nicolantonio, primary, Chiatante, Gianpasquale, additional, Gustin, Marco, additional, Cento, Michele, additional, Hardenberg, Jost Von, additional, Dell'Omo, Giacomo, additional, and Panuccio, Michele, additional
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- 2021
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5. Mechanistic models for pool nucleate boiling heat transfer: input and validation
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Kenning, David, Golobič, Iztok, Xing, Huijuan, Bašelj, Matej, Lojk, Vito, and Hardenberg, Jost von
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- 2006
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6. HighResMIP versions of EC-Earth: EC-Earth3P and EC-Earth3P-HR – description, model computational performance and basic validation
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Barcelona Supercomputing Center, Haarsma, Rein, Acosta Cobos, Mario César, Bakhshi, Rena, Bretonnière, Pierre-Antoine, Caron, Louis-Philippe, Castrillo, Miguel, Corti, Susanna, Davini, Paolo, Exarchou, Eleftheria, Fabiano, Federico, Fladrich, Uwe, Fuentes Franco, Ramon, García-Serrano, Javier, Hardenberg, Jost, von, Koenigk, Torben, Levine, Xavier, Meccia, Virna Loana, Noije, Twan, van, Oord, Gijs, van den, Palmeiro, Froila M., Rodrigo, Mario, Ruprich-Robert, Yohan, Sager, Philippe, Le, Tourigny, Etienne, Wang, Shiyu, Weele, Michiel, van, Wyser, Klaus, Barcelona Supercomputing Center, Haarsma, Rein, Acosta Cobos, Mario César, Bakhshi, Rena, Bretonnière, Pierre-Antoine, Caron, Louis-Philippe, Castrillo, Miguel, Corti, Susanna, Davini, Paolo, Exarchou, Eleftheria, Fabiano, Federico, Fladrich, Uwe, Fuentes Franco, Ramon, García-Serrano, Javier, Hardenberg, Jost, von, Koenigk, Torben, Levine, Xavier, Meccia, Virna Loana, Noije, Twan, van, Oord, Gijs, van den, Palmeiro, Froila M., Rodrigo, Mario, Ruprich-Robert, Yohan, Sager, Philippe, Le, Tourigny, Etienne, Wang, Shiyu, Weele, Michiel, van, and Wyser, Klaus
- Abstract
A new global high-resolution coupled climate model, EC-Earth3P-HR has been developed by the EC-Earth consortium, with a resolution of approximately 40 km for the atmosphere and 0.25∘ for the ocean, alongside with a standard-resolution version of the model, EC-Earth3P (80 km atmosphere, 1.0∘ ocean). The model forcing and simulations follow the High Resolution Model Intercomparison Project (HighResMIP) protocol. According to this protocol, all simulations are made with both high and standard resolutions. The model has been optimized with respect to scalability, performance, data storage and post-processing. In accordance with the HighResMIP protocol, no specific tuning for the high-resolution version has been applied. Increasing horizontal resolution does not result in a general reduction of biases and overall improvement of the variability, and deteriorating impacts can be detected for specific regions and phenomena such as some Euro-Atlantic weather regimes, whereas others such as the El Niño–Southern Oscillation show a clear improvement in their spatial structure. The omission of specific tuning might be responsible for this. The shortness of the spin-up, as prescribed by the HighResMIP protocol, prevented the model from reaching equilibrium. The trend in the control and historical simulations, however, appeared to be similar, resulting in a warming trend, obtained by subtracting the control from the historical simulation, close to the observational one., The EC-Earth simulations from SMHI were performed on resources provided by the Swedish National Infrastructure for Computing (SNIC). The EC-EARTH simulations from BSC were performed on resources provided by ECMWF and the Partnership for Advanced Computing in Europe (PRACE; MareNostrum, Spain). Froila M. Palmeiro and Javier García-Serrano were partially supported by the Spanish GRAVITOCAST project (ERC2018-092835) and the “Ramón y Cajal” program (RYC-2016-21181), respectively, and MR was supported by “Beca de collaboració amb la Universitat de Barcelona” (2019.4.FFIS.1). The EC-Earth simulations from CNR were performed on resources provided by CINECA and ECMWF (special projects SPITDAVI and SPITMAVI). The EC-Earth simulations from KNMI were partly performed on resources provided by ECMWF (special project SPNLHAAR)., Peer Reviewed, Postprint (published version)
- Published
- 2020
7. Earth System Model Evaluation Tool (ESMValTool) v2.0 – an extended set of large-scale diagnostics for quasi-operational and comprehensive evaluation of Earth system models in CMIP
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Barcelona Supercomputing Center, Eyring, Veronika, Bock, Lisa, Lauer, Axel, Righi, Mattia, Schlund, Manuel, Andela, Bouwe, Arnone, Enrico, Bellprat, Omar, Brötz, Björn, Caron, Louis-Philippe, Carvalhais, Nuno, Cionni, Irene, Cortesi, Nicola, Crezee, Bas, Davin, Edouard L., Davini, Paolo, Debeire, Kevin, Mora, Lee, de, Deser, Clara, Docquier, David, Earnshaw, Paul, Ehbrecht, Carsten, Gier, Bettina K., Gonzalez-Reviriego, Nube, Goodman, Paul, Hagemann, Stefan, Hardiman, Steven, Hassler, Birgit, Hunter, Alasdair, Kadow, Christopher, Kindermann, Stephan, Koirala, Sujan, Koldunov, Nikolay, Lejeune, Quentin, Lembo, Valerio, Lovato, Tomas, Lucarini, Valerio, Massonnet, François, Müller, Benjamin, Pandde, Amarjiit, Pérez-Zanón, Núria, Phillips, Adam, Predoi, Valeriu, Russell, Joellen, Sellar, Alistair, Serva, Federico, Stacke, Tobias, Swaminathan, Ranjini, Torralba, Verónica, Vegas-Regidor, Javier, Hardenberg, Jost, von, Weigel, Katja, Zimmermann, Klaus, Barcelona Supercomputing Center, Eyring, Veronika, Bock, Lisa, Lauer, Axel, Righi, Mattia, Schlund, Manuel, Andela, Bouwe, Arnone, Enrico, Bellprat, Omar, Brötz, Björn, Caron, Louis-Philippe, Carvalhais, Nuno, Cionni, Irene, Cortesi, Nicola, Crezee, Bas, Davin, Edouard L., Davini, Paolo, Debeire, Kevin, Mora, Lee, de, Deser, Clara, Docquier, David, Earnshaw, Paul, Ehbrecht, Carsten, Gier, Bettina K., Gonzalez-Reviriego, Nube, Goodman, Paul, Hagemann, Stefan, Hardiman, Steven, Hassler, Birgit, Hunter, Alasdair, Kadow, Christopher, Kindermann, Stephan, Koirala, Sujan, Koldunov, Nikolay, Lejeune, Quentin, Lembo, Valerio, Lovato, Tomas, Lucarini, Valerio, Massonnet, François, Müller, Benjamin, Pandde, Amarjiit, Pérez-Zanón, Núria, Phillips, Adam, Predoi, Valeriu, Russell, Joellen, Sellar, Alistair, Serva, Federico, Stacke, Tobias, Swaminathan, Ranjini, Torralba, Verónica, Vegas-Regidor, Javier, Hardenberg, Jost, von, Weigel, Katja, and Zimmermann, Klaus
- Abstract
The Earth System Model Evaluation Tool (ESMValTool) is a community diagnostics and performance metrics tool designed to improve comprehensive and routine evaluation of Earth system models (ESMs) participating in the Coupled Model Intercomparison Project (CMIP). It has undergone rapid development since the first release in 2016 and is now a well-tested tool that provides end-to-end provenance tracking to ensure reproducibility. It consists of (1) an easy-to-install, well-documented Python package providing the core functionalities (ESMValCore) that performs common preprocessing operations and (2) a diagnostic part that includes tailored diagnostics and performance metrics for specific scientific applications. Here we describe large-scale diagnostics of the second major release of the tool that supports the evaluation of ESMs participating in CMIP Phase 6 (CMIP6). ESMValTool v2.0 includes a large collection of diagnostics and performance metrics for atmospheric, oceanic, and terrestrial variables for the mean state, trends, and variability. ESMValTool v2.0 also successfully reproduces figures from the evaluation and projections chapters of the Intergovernmental Panel on Climate Change (IPCC) Fifth Assessment Report (AR5) and incorporates updates from targeted analysis packages, such as the NCAR Climate Variability Diagnostics Package for the evaluation of modes of variability, the Thermodynamic Diagnostic Tool (TheDiaTo) to evaluate the energetics of the climate system, as well as parts of AutoAssess that contains a mix of top–down performance metrics. The tool has been fully integrated into the Earth System Grid Federation (ESGF) infrastructure at the Deutsches Klimarechenzentrum (DKRZ) to provide evaluation results from CMIP6 model simulations shortly after the output is published to the CMIP archive. A result browser has been implemented that enables advanced monitoring of the evaluation results by a broad user community at much faster timescales than what was poss, This research has been supported by Horizon 2020 (grant nos. 641816, 727862, 641727, and 824084), the Copernicus Climate Change Service (C3S) (Metrics and Access to Global Indices for Climate Projections, MAGIC), the Helmholtz Association (Advanced Earth System Model Evaluation for CMIP, EVal4CMIP), the Deutsche Forschungsgemeinschaft (grant no. 274762653), the Federal Ministry of Education and Research (BMBF) (grant no. CMIP6-DICAD), and the European Space Agency (ESA Climate Change Initiative Climate Model User Group, ESA CCI CMUG)., Peer Reviewed, Postprint (published version)
- Published
- 2020
8. Seasonal forecasting of snow resources at Alpine sites.
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Terzago, Silvia, Bongiovanni, Giulio, and Hardenberg, Jost von
- Abstract
Climate warming in mountain regions is resulting in glacier shrinking, seasonal snow cover reduction, changes in the amount and seasonality of meltwater runoff, with consequences on water availability. Droughts are expected to become more severe in the future with economical and environmental losses both locally and downstream. Effective adaptation strategies involve multiple time scales, and seasonal forecasts can help in the optimization of the available snow/water resources with lead times of several months. We developed a prototype to generate seasonal forecasts of snow depth and snow water equivalent with starting date November 1
st and lead times of 7 months, so up to May 31st of the following year. The prototype has been codesigned with end users in the field of water management, hydropower production and of mountain ski tourism, meeting their needs in terms of indicators, time resolution of the forecasts, visualization of the forecast outputs. In this paper we present the modelling chain, based on the seasonal forecasts of ECMWF and Météo-France seasonal prediction systems, made available through the Copernicus Climate Change Service (C3S) Climate Data Store. Seasonal forecasts of precipitation, near-surface air temperature, radiative fluxes, wind and relative humidity are bias-corrected and downscaled to three sites in the Western Italian Alps, and finally used as input for the physically-based multi-layer snow model SNOWPACK. The RainFARM stochastic downscaling procedure is applied to precipitation data in order to allow an estimate of uncertainties due to the downscaling method. The skill of the prototype in predicting the monthly snow depth evolution from November to May in each season of the hindcast period 1995-2015 are demonstrated using both deterministic and probabilistic metrics. Forecast skills are determined with respect to a simple forecasting method based on the climatology, and station measurements are used as reference data. The prototype shows very good skills at predicting the tercile category, i.e. snow depth below- and above-normal, in the winter (lead time 2-3-4 months) and spring (lead times 5-6-7 months) ahead: snow depth is predicted with higher accuracy (Brier Skill Score) and higher discrimination (Area Under the ROC Curve Skill Score) with respect to a simple forecasting method based on the climatology. Ensemble mean monthly snow depth forecasts are significantly correlated with observations not only at short lead time 1 and 2 months (November and December) but also at lead time 5 and 6 months (March and April) when employing the ECMWFS5 forcing. Moreover the prototype shows skill at predicting extremely dry seasons, i.e. seasons with snow depth below the 10th percentile, while skills at predicting snow depth above the 90th percentile are model-, station- and score-dependent. No remarkable differences are found among the skill scores when the precipitation input is bias-corrected, downscaled or bias-corrected and downscaled compared to the case in which raw data are employed, suggesting that skill scores are weakly sensitive to the treatment of the precipitation input. [ABSTRACT FROM AUTHOR]- Published
- 2022
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9. Expression and predictive value of lymph-specific markers in urothelial carcinoma of the bladder
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Hardenberg, Jost von, Martini, Thomas, Knauer, Antje, Ströbel, Philipp, Becker, Andreas, Herrmann, Edwin, Schubert, Charlotte, Steidler, Annette, and Bolenz, Christian
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- 2014
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10. Climate bistability of Earth-like exoplanets
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Murante, Giuseppe, primary, Provenzale, Antonello, additional, Vladilo, Giovanni, additional, Taffoni, Giuliano, additional, Silva, Laura, additional, Palazzi, Elisa, additional, Hardenberg, Jost von, additional, Maris, Michele, additional, Londero, Elisa, additional, Knapic, Cristina, additional, and Zorba, Sonia, additional
- Published
- 2019
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11. Forecasting wave height probabilities with numerical weather prediction models
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Roulston, Mark S., Ellepola, Jerome, Hardenberg, Jost von, and Smith, Leonard A.
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- 2005
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12. Seasonal Prediction of the evolution of ice and snow resources
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Paranunzio, Roberta, Nigrelli, Guido, Mortara, Giovanni, Terzago, Silvia, Hardenberg, Jost Von, and Chiarle, Marta
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- 2019
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13. CSTools: a new R package for the calibration, combination, downscaling and analysis of seasonal forecasts
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Caron, Louis-Philippe, Pérez Zanón, Núria, Álvarez-Castro, Carmen, Batté, Lauriane, Corti, Susanna, Domínguez Alonso, Marta, Fabiano, Federico, Gualdi, Silvio, Hardenberg, Jost von, Lledó, Llorenç, Manubens, Nicolau, Marson, Paola, Materia, Stefano, Sánchez García, Eroteida, Schaeybroeck, Bert Van, Torralba, Verónica, Terzago, Silvia, Verfaillie, Deborah, and Volpi, Danila
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Seasonal forecasts ,Copernicus Climate Change Service ,R package - Abstract
Póster presentado en: EGU General Assembly 2019 celebrada del 7 al 12 de abril en Viena, Austria. MEDSCOPE is co-funded by the H2020 ERA-Net ERA4CS European Research Area for Climate Services (Grant 690462).
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- 2019
14. Current status of MEDSCOPE CS-Tools
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Caron, Louis-Philippe, Pérez Zanón, Núria, Álvarez-Castro, Carmen, Batté, Lauriane, Corti, Susanna, Domínguez Alonso, Marta, Fabiano, Federico, Gualdi, Silvio, Hardenberg, Jost von, Lledó, Llorenç, Manubens, Nicolau, Marson, Paola, Materia, Stefano, Sánchez García, Eroteida, Schaeybroeck, Bert Van, Torralba, Verónica, Terzago, Silvia, Verfaillie, Deborah, and Volpi, Danila
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Seasonal Forecasts ,R package ,CSTools - Abstract
Presentación realizada en: 13º Mediterranean Climate Outlook Forum (MedCOF) celebrado de forma online entre el 15 de octubre y el 26 de noviembre de 2019.
- Published
- 2019
15. EC-Earth3-AerChem, a global climate model with interactive aerosols and atmospheric chemistry participating in CMIP6.
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Noije, Twan van, Bergman, Tommi, Sager, Philippe Le, O'Donnell, Declan, Makkonen, Risto, Gonçalves-Ageitos, María, Döscher, Ralf, Fladrich, Uwe, Hardenberg, Jost von, uwe.fladrich@smhi.se, Keskinen, Jukka-Pekka, Korhonen, Hannele, Laakso, Anton, Myriokefalitakis, Stelios, Ollinaho, Pirkka, García-Pando, Carlos Pérez, Reerink, Thomas, Schrödner, Roland, Wyser, Klaus, and Yang, Shuting
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ATMOSPHERIC chemistry ,ATMOSPHERIC models ,ATMOSPHERIC aerosols ,CLIMATE sensitivity ,ATMOSPHERIC temperature - Abstract
This paper documents the global climate model EC-Earth3-AerChem, one of the members of the EC-Earth3 family of models participating in the Coupled Model Intercomparison Project phase 6 (CMIP6). EC-Earth3-AerChem has interactive aerosols and atmospheric chemistry and contributes to the Aerosols and Chemistry Model Intercomparison Project (AerChemMIP). In this paper, we give an overview of the model and describe in detail how it differs from the other EC-Earth3 configurations, and what the new features are compared to the previously documented version of the model (EC-Earth 2.4). We explain how the model was tuned and spun up under pre-industrial conditions and characterize the model's general performance on the basis of a selection of coupled simulations conducted for CMIP6. The mean energy imbalance at the top of the atmosphere in the pre-industrial control simulation is -0.10 ± 0.25 W m
-2 and shows no significant drift. The corresponding mean global surface air temperature is 14.05 ± 0.16 °C, with a small drift of -0.075 ± 0.009 °C per century. The model's effective equilibrium climate sensitivity is estimated at 3.9 °C and its transient climate response at 2.1 °C. The CMIP6 historical simulation displays spurious interdecadal variability in Northern Hemisphere temperatures, resulting in a large spread among ensemble members and a tendency to underestimate observed annual surface temperature anomalies from the early 20th century onwards. The observed warming of the Southern Hemisphere is well reproduced by the model. Compared to the ERA5 reanalysis of the European Centre for Medium-Range Weather Forecasts, the ensemble mean surface air temperature climatology for 1995-2014 has an average bias of -0.86 ± 0.35 °C in the Northern Hemisphere and 1.29 ± 0.05 °C in the Southern Hemisphere. The Southern Hemisphere warm bias is largely caused by errors in shortwave cloud radiative effects over the Southern Ocean, a deficiency of many climate models. Changes in the emissions of near-term climate forcers (NTCFs) have significant climate effects from the 20th century onwards. For the SSP3-7.0 shared socio-economic pathway, the model gives a global warming at the end of the 21st century (2091-2100) of 4.9 °C above the pre-industrial mean. A 0.5 °C stronger warming is obtained for the AerChemMIP scenario with reduced emissions of NTCFs. With concurrent reductions of future methane concentrations, the warming is projected to be reduced by 0.5 °C. [ABSTRACT FROM AUTHOR]- Published
- 2020
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16. Climate bistability of Earth-like exoplanets.
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Murante, Giuseppe, Provenzale, Antonello, Vladilo, Giovanni, Taffoni, Giuliano, Silva, Laura, Palazzi, Elisa, Hardenberg, Jost von, Maris, Michele, Londero, Elisa, Knapic, Cristina, and Zorba, Sonia
- Subjects
STELLAR radiation ,HABITABLE planets ,EXTRASOLAR planets ,SEAS ,CLIMATOLOGY ,EARTH'S orbit ,LAGRANGIAN points - Abstract
Before about 500 million years ago, most probably our planet experienced temporary snowball conditions, with continental and sea ices covering a large fraction of its surface. This points to a potential bistability of Earth's climate that can have at least two different (statistical) equilibrium states for the same external forcing (i.e. solar radiation). Here, we explore the probability of finding bistable climates in Earth-like exoplanets and consider the properties of planetary climates obtained by varying the semimajor orbital axis (thus, received stellar radiation), eccentricity and obliquity, and atmospheric pressure. To this goal, we use the Earth-like planet surface temperature model (ESTM), an extension of one-dimensional Energy Balance Models developed to provide a numerically efficient climate estimator for parameter sensitivity studies and long climatic simulations. After verifying that the ESTM is able to reproduce Earth climate bistability, we identify the range of parameter space where climate bistability is detected. An intriguing result of this work is that the planetary conditions that support climate bistability are remarkably similar to those required for the sustenance of complex, multicellular life on the planetary surface. The interpretation of this result deserves further investigation, given its relevance for the potential distribution of life in exoplanetary systems. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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17. On the key role of droughts in the dynamics of summer fires in Mediterranean Europe
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Barcelona Supercomputing Center, Turco, Marco, Hardenberg, Jost von, AghaKouchak, Amir, Llasat, Maria C., Provenzale, Antonello, Trigo, Ricardo M., Barcelona Supercomputing Center, Turco, Marco, Hardenberg, Jost von, AghaKouchak, Amir, Llasat, Maria C., Provenzale, Antonello, and Trigo, Ricardo M.
- Abstract
Summer fires frequently rage across Mediterranean Europe, often intensified by high temperatures and droughts. According to the state-of-the-art regional fire risk projections, in forthcoming decades climate effects are expected to become stronger and possibly overcome fire prevention efforts. However, significant uncertainties exist and the direct effect of climate change in regulating fuel moisture (e.g. warmer conditions increasing fuel dryness) could be counterbalanced by the indirect effects on fuel structure (e.g. warmer conditions limiting fuel amount), affecting the transition between climate-driven and fuel-limited fire regimes as temperatures increase. Here we analyse and model the impact of coincident drought and antecedent wet conditions (proxy for the climatic factor influencing total fuel and fine fuel structure) on the summer Burned Area (BA) across all eco-regions in Mediterranean Europe. This approach allows BA to be linked to the key drivers of fire in the region. We show a statistically significant relationship between fire and same-summer droughts in most regions, while antecedent climate conditions play a relatively minor role, except in few specific eco-regions. The presented models for individual eco-regions provide insights on the impacts of climate variability on BA, and appear to be promising for developing a seasonal forecast system supporting fire management strategies., We thank the European Forest Fire Information System-EFFIS (http://effis.jrc.ec.europa.eu) of the European Commission Joint Research Centre for the fire data. We acknowledge the SPEI data providers (http://sac.csic. es/spei/database.html). Special thanks to Joaquín Bedia, Esteve Canyameras, Xavier Castro and Andrej Ceglar for helpful discussions on the study. This work was partially funded by the Project of Interest “NextData” of the Italian Ministry for Education, University and Research and by the EU H2020 Project 641762 “ECOPOTENTIAL: Improving Future Ecosystem Benefits through Earth Observations”. Ricardo Trigo was supported by IMDROFLOOD funded by Portuguese FCT (WaterJPI/0004/2014)., Peer Reviewed, Postprint (published version)
- Published
- 2017
18. High Resolution Model Intercomparison Project (HighResMIP v1.0) for CMIP6
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Barcelona Supercomputing Center, Haarsma, Reindert J., Roberts, Malcolm J., Vidale, Pier L., Senior, Catherine A., Bellucci, Alessio, Bao, Qing, Chang, Ping, Corti, Susanna, Fuckar, Neven S., Guemas, Virginie, Hardenberg, Jost von, Hazeleger, Wilco, Kodama, Chihiro, Koenigk, Torben, Leung, L. Ruby, Lu, Jian, Luo, Jing-Jia, Mao, Jiafu, Mizielinski, Matthew S., Mizuta, Ryo, Nobre, Paulo, Satoh, Masaki, Scoccimarro, Enrico, Semmler, Tido, Small, Justin, von Storch, Jing-Song, Barcelona Supercomputing Center, Haarsma, Reindert J., Roberts, Malcolm J., Vidale, Pier L., Senior, Catherine A., Bellucci, Alessio, Bao, Qing, Chang, Ping, Corti, Susanna, Fuckar, Neven S., Guemas, Virginie, Hardenberg, Jost von, Hazeleger, Wilco, Kodama, Chihiro, Koenigk, Torben, Leung, L. Ruby, Lu, Jian, Luo, Jing-Jia, Mao, Jiafu, Mizielinski, Matthew S., Mizuta, Ryo, Nobre, Paulo, Satoh, Masaki, Scoccimarro, Enrico, Semmler, Tido, Small, Justin, and von Storch, Jing-Song
- Abstract
Robust projections and predictions of climate variability and change, particularly at regional scales, rely on the driving processes being represented with fidelity in model simulations. The role of enhanced horizontal resolution in improved process representation in all components of the climate system is of growing interest, particularly as some recent simulations suggest both the possibility of significant changes in large-scale aspects of circulation as well as improvements in small-scale processes and extremes. However, such high-resolution global simulations at climate timescales, with resolutions of at least 50 km in the atmosphere and 0.25° in the ocean, have been performed at relatively few research centres and generally without overall coordination, primarily due to their computational cost. Assessing the robustness of the response of simulated climate to model resolution requires a large multi-model ensemble using a coordinated set of experiments. The Coupled Model Intercomparison Project 6 (CMIP6) is the ideal framework within which to conduct such a study, due to the strong link to models being developed for the CMIP DECK experiments and other model intercomparison projects (MIPs). Increases in high-performance computing (HPC) resources, as well as the revised experimental design for CMIP6, now enable a detailed investigation of the impact of increased resolution up to synoptic weather scales on the simulated mean climate and its variability. The High Resolution Model Intercomparison Project (HighResMIP) presented in this paper applies, for the first time, a multi-model approach to the systematic investigation of the impact of horizontal resolution. A coordinated set of experiments has been designed to assess both a standard and an enhanced horizontal-resolution simulation in the atmosphere and ocean. The set of HighResMIP experiments is divided into three tiers consisting of atmosphere-only and coupled runs and spanning the period 1950–2050, with the p, PRIMAVERA project members (Malcolm J. Roberts, Reindert J. Haarsma, Pier Luigi Vidale, Torben Koenigk, Virginie Guemas, Susanna Corti, Jost von Hardenberg, Jin-Song von Storch,Wilco Hazeleger, Catherine A. Senior, Matthew S. Mizielinsky, Tido Semmler, Alessio Bellucci, Enrico Scoccimarro, Neven S. Fuckar) acknowledge funding received from the European Commission under grant agreement 641727 of the Horizon 2020 research programme. Chihiro Kodama acknowledges Y. Yamada, M. Nakano, T. Nasuno, T. Miyakawa, and H. Miura for analysis ideas. Neven S. Fuckar acknowledges support of the Juan de la Ciervaincorporación postdoctoral fellowship from the Ministry of Economy and Competitiveness of Spain. L. Ruby Leung and Jian Lu acknowledge support from the U.S. Department of Energy Office of Science Biological and Environmental Research as part of the Regional and Global Climate Modeling Program. The Pacific Northwest National Laboratory is operated for the DOE by Battelle Memorial Institute under contract DE-AC05-76RLO1830. Jiafu Mao is supported by the Biogeochemistry-Climate Feedbacks Scientific Focus Area project funded through the Regional and Global Climate Modeling Program in Climate and Environmental Sciences Division (CESD) of the Biological and Environmental Research (BER) Program in the U.S. Department of Energy Office of Science. Oak Ridge National Laboratory is managed by UTBATTELLE for the DOE under contract DE-AC05-00OR22725. Paulo Nobre acknowledges support from CNPq grant nos. 573797/2008-0 and 490237/2011-8, and FAPESP grant no. 2008/57719-9. Chihiro Kodama and Masaki Satoh are supported by the Program for Risk Information on Climate Change (SOSEI) and the FLAGSHIP2020 within the priority study4 (Advancement of meteorological and global environmental predictions utilizing observational “Big Data”), which are promoted by the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan. Ping Chang is supported by US National Science Foundation gra, Peer Reviewed, Postprint (published version)
- Published
- 2016
19. Tropical origin for the impacts of the Atlantic Multidecadal Variability on the Euro-Atlantic climate
- Author
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Davini, Paolo, primary, Hardenberg, Jost von, additional, and Corti, Susanna, additional
- Published
- 2015
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20. Thrombopoietin limits IL-6 release but fails to attenuate liver injury in two hepatic stress models
- Author
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Eipel, Christian, primary, Hardenberg, Jost von, additional, Negendank, Steffen, additional, Abshagen, Kerstin, additional, and Vollmar, Brigitte, additional
- Published
- 2009
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21. Mechanistic models for pool nucleate boiling heat transfer: input and validation
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Kenning, David, primary, Golobič, Iztok, additional, Xing, Huijuan, additional, Bašelj, Matej, additional, Lojk, Vito, additional, and Hardenberg, Jost von, additional
- Published
- 2005
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22. Rapidly rotating Rayleigh-Bénard convection with a tilted axis.
- Author
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Novi, Lyuba, Hardenberg, Jost von, Hughes, David W., Provenzale, Antonello, and Spiegel, Edward A.
- Subjects
- *
RAYLEIGH-Benard convection , *ROTATING fluid , *FLUID dynamics , *PLANETARY atmospheres , *GRAVITY - Abstract
We numerically explore the dynamics of an incompressible fluid heated from below, boundedby free-slip horizontal plates and periodic lateral boundary conditions, subject to rapidrotation about a distant axis that is tilted with respect to the gravity vector (supposed vertical).The angle φ between the rotation axis and the horizontal plane measures the tilting of therotation axis and it can be taken as a proxy for latitude, if we think of a local Cartesianrepresentation of the convective dynamics in a rotating fluid shell. The results of thesimulations indicate the existence of three different convective regimes, depending on thevalue of φ: (1) sheared, intermittent large-scale winds in the direction perpendicular to theplane defined by the gravity and rotation vectors, when rotation is "horizontal" (φ = 0); (2) alarge-scale cyclonic vortex tilted along the rotation axis, when the angle between the rotationaxis and the gravity vector is relatively small (φ between about 45∘ and 90∘); (3)a new intermediate regime characterized by vertically sheared large-scale windsperpendicular to both gravity and rotation. In this regime, the winds are organized inbands that are tilted along the rotation axis, with unit horizontal wavenumber inthe plane defined by gravity and rotation, at values of φ less than about 60∘. Thisintermediate solution, studied for the first time in this work, is characterized by weakervertical heat transport than the cases with large-scale vortices. For intermediatevalues of φ (between about 45∘ and 60∘) the banded, sheared solution coexistswith the large-scale vortex solution, and different initial conditions lead to one orthe other dynamical behavior. A discussion of the possible implications of theseresults for the dynamics of rapidly-rotating planetary atmospheres is provided. [ABSTRACT FROM AUTHOR]
- Published
- 2019
23. Euro-Atlantic climate variability in High-Resolution GCMs: improving atmospheric blocking for the wrong reasons.
- Author
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Davini, Paolo, D'Andrea, Fabio, Corti, Susanna, Riviere, Gwendal, and Hardenberg, Jost von
- Published
- 2019
24. Sensitivity of snow models to the accuracy of the meteorological forcing in a mountain environment.
- Author
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Terzago, Silvia, Pogliotti, Paolo, Cremonese, Edoardo, Cella, Umberto Morra di, Gabellani, Simone, Piazzi, Gaia, Dolia, Daniele, Cassardo, Claudio, Andreoli, Valentina, Hardenberg, Jost von, Palazzi, Elisa, and Provenzale, Antonello
- Published
- 2019
25. Elevation-dependent warming and its driving mechanisms in global climate model simulations at different spatial resolutions.
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Palazzi, Elisa, Mortarini, Luca, Terzago, Silvia, and Hardenberg, Jost von
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- 2019
26. Tuning the Planet Simulator Earth system Model of Intermediate Complexity for climate sensitivity studies.
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Angeloni, Michela, Palazzi, Elisa, and Hardenberg, Jost von
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- 2019
27. Physically-based assessment of the effects of climate change on landslide hazards in Central Italy.
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Alvioli, Massimiliano, Melillo, Massimo, Guzzetti, Fausto, Rossi, Mauro, Palazzi, Elisa, Hardenberg, Jost von, Brunetti, Maria Teresa, and Peruccacci, Silvia
- Published
- 2019
28. miR-10a-5p and miR-29b-3p as Extracellular Vesicle-Associated Prostate Cancer Detection Markers.
- Author
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Worst TS, Previti C, Nitschke K, Diessl N, Gross JC, Hoffmann L, Frey L, Thomas V, Kahlert C, Bieback K, Crigna AT, Fricke F, Porubsky S, Westhoff N, Hardenberg JV, Nuhn P, Erben P, Michel MS, and Boutros M
- Abstract
Extracellular vesicles (EVs) are shed by many different cell types. Their nucleic acids content offers new opportunities for biomarker research in different solid tumors. The role of EV RNA in prostate cancer (PCa) is still largely unknown. EVs were isolated from different benign and malignant prostate cell lines and blood plasma from patients with PCa ( n = 18) and controls with benign prostatic hyperplasia (BPH) ( n = 7). Nanoparticle tracking analysis (NTA), Western blot, electron microscopy, and flow cytometry analysis were used for the characterization of EVs. Non-coding RNA expression profiling of PC3 metastatic PCa cells and their EVs was performed by next generation sequencing (NGS). miRNAs differentially expressed in PC3 EVs were validated with qRT-PCR in EVs derived from additional cell lines and patient plasma and from matched tissue samples. 92 miRNAs were enriched and 48 miRNAs were depleted in PC3 EVs compared to PC3 cells, which could be confirmed by qRT-PCR. miR-99b-5p was significantly higher expressed in malignant compared to benign EVs. Furthermore, expression profiling showed miR-10a-5p ( p = 0.018) and miR-29b-3p ( p = 0.002), but not miR-99b-5p, to be overexpressed in plasma-derived EVs from patients with PCa compared with controls. In the corresponding tissue samples, no significant differences in the miRNA expression could be observed. We thus propose that EV-associated miR-10a-5p and miR-29b-3p could serve as potential new PCa detection markers., Competing Interests: The authors declare no conflicts of interest.
- Published
- 2019
- Full Text
- View/download PDF
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