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16 results on '"Harasaki, Tamako"'

3. Activity of capuramycin analogues against Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium intracellularein vitro and in vivo

Author

Koga, Tetsufumi, primary, Fukuoka, Takashi, additional, Doi, Norio, additional, Harasaki, Tamako, additional, Inoue, Harumi, additional, Hotoda, Hitoshi, additional, Kakuta, Masayo, additional, Muramatsu, Yasunori, additional, Yamamura, Naotoshi, additional, Hoshi, Misa, additional, and Hirota, Takashi, additional

Published
2004
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4. Synthesis and antimycobacterial activity of capuramycin analogues. Part 1: substitution of the azepan-2-one moiety of capuramycin

Author

Hotoda, Hitoshi, primary, Furukawa, Miyuki, additional, Daigo, Makiko, additional, Murayama, Kazuhiro, additional, Kaneko, Masakatsu, additional, Muramatsu, Yasunori, additional, Ishii, Michiko Miyazawa, additional, Miyakoshi, Shun-ichi, additional, Takatsu, Toshio, additional, Inukai, Masatoshi, additional, Kakuta, Masayo, additional, Abe, Tomomi, additional, Harasaki, Tamako, additional, Fukuoka, Takashi, additional, Utsui, Yukio, additional, and Ohya, Satoshi, additional

Published
2003
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10. Synthesis and in Vitro Antifungal Activities of Novel Triazole Antifungal Agent CS-758.

Author

KONOSU, Toshiyuki, primary, OIDA, Sadao, additional, NAKAMURA, Yoshie, additional, SEKI, Shinobu, additional, UCHIDA, Takuya, additional, SOMADA, Atsushi, additional, MORI, Makoto, additional, HARADA, Yoshiko, additional, KAMAI, Yasuki, additional, HARASAKI, Tamako, additional, FUKUOKA, Takashi, additional, OHYA, Satoshi, additional, YASUDA, Hiroshi, additional, SHIBAYAMA, Takahiro, additional, INOUE, Shin-ichi, additional, NAKAGAWA, Akihiko, additional, and SETA, Yasuo, additional

Published
2001
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14. Efficacy of CS-834 against Experimental Pneumonia Caused by Penicillin-Susceptible and -Resistant Streptococcus pneumoniaein Mice

Author

Fukuoka, Takashi, Kawada, Harumi, Kitayama, Akiko, Koga, Tetsufumi, Kubota, Mikie, Harasaki, Tamako, Kamai, Yasuki, Ohya, Satoshi, Yasuda, Hiroshi, Iwata, Masayuki, and Kuwahara, Shogo

Abstract

ABSTRACTThe efficacy of CS-834, a novel oral carbapenem, was assessed by using a murine model of pneumonia caused by penicillin-susceptible and penicillin-resistant Streptococcus pneumoniaeand was compared with those of oral cephems, i.e., cefteram pivoxil, cefpodoxime proxetil, cefdinir, and cefditoren pivoxil. Intranasal inoculation of 106CFU of penicillin-susceptible or penicillin-resistant S. pneumoniaein the exponential growth phase induced pneumonia and bacteremia in ddY mice within 48 h. For the treatment of infections caused by the penicillin-susceptible strain the antibiotics were administered orally at 0.4, 2, and 10 mg/kg of body weight twice daily for 2 days beginning at 24 h after bacterial inoculation, and for the treatment of infections caused by a penicillin-resistant strain the antibiotics were administered at 2, 10, and 50 mg/kg twice daily for 2 days beginning at 24 h after bacterial inoculation. Among the antibiotics tested, CS-834 exhibited the most potent efficacy against both types of strains. Against infections caused by penicillin-susceptible S. pneumoniae, CS-834 at all doses significantly reduced the numbers of viable cells in both the lungs and blood. Cefpodoxime proxetil at all doses and cefteram pivoxil and cefditoren pivoxil at doses of 2 and 10 mg/kg showed comparable efficacies. Against infections caused by penicillin-resistant S. pneumoniae, CS-834 at doses of 10 and 50 mg/kg showed the most potent efficacy among the antibiotics tested, resulting in the maximum decrease in the numbers of viable cells in the lungs. Comparable efficacies were observed with cefteram pivoxil and cefpodoxime proxetil at doses of 50 mg/kg each. The concentration of CS-834 in the lungs and blood was higher than that of cefdinir and was lower than those of the other antibiotics tested, suggesting that the potent therapeutic efficacy of CS-834 reflects its strong activity against S. pneumoniae.

Published
1998
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16. <atl>Synthesis of Sordaricin Analogues as Potent Antifungal Agents against Candida albicans

Author

Kaneko, Satoru, Uchida, Takuya, Shibuya, Satoshi, Honda, Takeshi, Kawamoto, Isao, Harasaki, Tamako, Fukuoka, Takashi, and Konosu, Toshiyuki

Subjects
*CYCLOHEXANE, *AMINE oxidase, *ANTIFUNGAL agents, *CANDIDA albicans
Abstract

Sordaricin derivatives possessing a cyclohexane ring appendage attached via an ether, thioether, amine, oxime, ester or amide linkage were synthesized and their antifungal activity was evaluated in vitro. Compounds containing a thioether bond or an oxime bond as a linkage exhibited potent MICs (≤0.125 μg/mL) against four Candida albicans strains including azole-low-susceptible strains. They were also active (MIC ≤0.125 μg/mL) against Candida glabrata. Their in vivo efficacy was confirmed in a murine intravenous infection model with Candida albicans. [Copyright &y& Elsevier]

Published
2002
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