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5,312 results on '"Harada, Y."'

1. BepiColombo observations of cold oxygen and carbon ions in the flank of the induced magnetosphere of Venus

Author

Hadid, L. Z., Delcourt, D., Saito, Y., Fränz, M., Yokota, S., Fiethe, B., Verdeil, C., Katra, B., Leblanc, F., Fischer, H., Persson, M., Aizawa, S., André, N., Harada, Y., Fedorov, A., Fontaine, D., Krupp, N., Michalik, H., Berthelier, J-J., Krüger, H., Murakami, G., Matsuda, S., Heyner, D., Auster, H.-U., Richter, I., Mieth, J. Z. D., Schmid, D., and Fischer, D.

Published
2024
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2. Relationship Between Diabetic Chorea and Timing of MRI Findings: A Systematic Review with Case Reports

Author

Otaka Y, Harada Y, Sugawara N, Shimizu T, and Yasui-Furukori N

Subjects
hyperglycemia, hemichorea, hemiballismus, diabetes, movement disorders, Medicine (General), R5-920
Abstract

Yumi Otaka,1 Yukinori Harada,1 Norio Sugawara,2 Taro Shimizu,1 Norio Yasui-Furukori2 1Department of Diagnostic and Generalist Medicine, Dokkyo Medical University, School of Medicine, Tochigi, Japan; 2Department of Psychiatry, Dokkyo Medical University, School of Medicine, Tochigi, JapanCorrespondence: Norio Yasui-Furukori, Department of Psychiatry, Dokkyo Medical University, School of Medicine, Mibu, Shimotsuga, Tochigi, 321-0293, Japan, Tel +81-282-86-1111, Fax +81-282-86-5187, Email furukori@dokkyomed.ac.jpBackground: Diabetic chorea is a rare complication of diabetes mellitus for which head MRI is the most common diagnostic imaging modality. Cases have been reported where CT and/or MRI findings are inconsistent or clinical symptoms and imaging findings do not appear simultaneously. We aimed to compile the cases in which imaging findings appeared on MRI retests and to examine in a systematic review whether temporal differences in the appearance of imaging findings correlate with clinical characteristics.Case Presentation: An 80-year-old man with type 2 diabetes mellitus came to a hospital with abnormal movements of the left upper and lower extremities. Two days after the first visit, his symptoms flared up, and his head MRI showed an old cerebral infarction and no new lesion. On day 14, he retested T1-weighted imaging and showed a high signal in the right putamen, which was considered diabetic chorea. Blood glucose was controlled with insulin, and the involuntary movements disappeared.Methods: PubMed and ICHUSHI were searched to identify patients with diabetic chorea who had undergone MRI retests. Patients grouped by the temporal change in the presence/absence of imaging findings were compared on age, sex, duration of diabetes mellitus, blood glucose level, HbA1c level, side of involuntary movement, time to first MRI, and follow-up MRI.Results: Of the 64 cases analyzed, 43 (67.2%) were female. The mean age was 69.0 years. 16 (25.0%) had worsening findings upon MRI retesting, 37 (57.8%) had improvement, and 10 (15.6%) had unchanged findings. There were no significant differences in age, sex, mean blood glucose level or HbA1c at onset among the groups.Conclusion: There was no association between the pattern of appearance of imaging findings over time and clinical characteristics, including glucose levels. If initial MRI findings are negative, MRI retesting after a certain time may help diagnose diabetic chorea.Keywords: hyperglycemia, hemichorea, hemiballismus, diabetes, movement disorders

Published
2023

3. Simulation of light propagation in medium with an ultrasonically induced refractive index gradient.

Author

Harada, Y., Ishikawa, M., Kuroda, Y., Matsukawa, M., and Koyama, D.

Subjects
*LIGHT propagation, *ULTRASONIC waves, *LAGRANGE equations, *LASER beams, *LIFE sciences, *PHOTONICS, *EULER-Lagrange equations, *REFRACTIVE index
Abstract

Modulation of the refractive index in a medium by external stimuli enables fast and reversible control of light propagation. This technology for controlling light has led to new discoveries in a wide range of research fields from physics to life sciences and has played a major role in the development of photonics devices. In this article, we focus on ultrasound as an external stimulus and have devised a method to control the refractive index of a medium using ultrasound. Our research group has previously discovered that a giant refractive-index gradient (Δn on the order of 10−2) was induced when water was irradiated with high-frequency (100 MHz range), high-intensity (on the order of MPa) ultrasound. Here, we report ray-tracing simulations in a medium with a refractive-index gradient induced by ultrasonic radiation. A numerical model of the refractive-index gradient was developed based on the experimental data, and ray-tracing simulations were performed using the Euler–Lagrange equation. The ray-tracing simulation results were close numerically to the profiles of the laser beam observed in the experiment when the laser beam was incident on the refractive-index-gradient medium. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Electronic surface reconstruction of TiO2 nanocrystals revealed by resonant inelastic x-ray scattering

Author

Chuang, CH, Chen, CM, Shao, YC, Yeh, PH, Chang, CM, Pong, WF, Kapilashrami, M, Glans, PA, Gul, S, Wang, G, Li, Y, Zhang, J, Miyawaki, J, Niwa, H, Harada, Y, Chen, JM, and Guo, J

Subjects
Physical Sciences, Engineering, Applied Physics
Abstract

The identification of lattice multiphases in TiO2 nanocrystals is studied by high resolution transmission electron microscope and electron diffraction patterns. Based on the spectroscopic analysis using soft x-ray absorption and resonant inelastic soft x-ray scattering, it is believed that the oxygen vacancies at the interface exhibit structural distortion of the TiO68−cluster around the defect site as for the multiphase lattice. We elucidate that the extra 3d electrons nearby induce the inelastic scattering features with the excitation energy dependence owing to different energy relaxation processes, a characteristic of the electron-phonon coupling or the nature of the electron-hole pair at the intermediate state. The manifold dd excitations driven by the strong interaction between Ti-3d and O-2p electrons are noticeably rich, coexisting on both Ti and O sites. This sophisticated experiment can advance the perspective of nanocomposite TiO2 for various interactions of surface Ti3+ in applications of future devices.

Published
2021

5. Gilteritinib Affects the Selection of Dominant Clones in Clonal Hematopoiesis: Sequential Genetic Analysis of an FLT3-ITD Positive AML Patient with Long-Term Gilteritinib Therapy

Author

Katagiri S, Furuya N, Akahane D, Chi S, Minami Y, Harada Y, Harada H, and Gotoh A

Subjects
gilteritinib, flt3-itd, cbl, monosomy 7, clonal hematopoiesis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Seiichiro Katagiri,1 Nahoko Furuya,1 Daigo Akahane,1 SungGi Chi,2 Yosuke Minami,2 Yuka Harada,3 Hironori Harada,4 Akihiko Gotoh1 1Department of Hematology, Tokyo Medical University, Tokyo, Japan; 2Department of Hematology, National Cancer Center Hospital East, Chiba, Japan; 3Department of Clinical Laboratory, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan; 4Laboratory of Oncology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Tokyo, JapanCorrespondence: Seiichiro Katagiri, Department of Hematology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan, Tel +81-3-3342-6111 (ext. 5895), Fax +81-3-5381-6651, Email patchsei@yahoo.co.jpAbstract: We performed sequential molecular analyses of a 75-year-old woman with de novo FLT3-ITD positive acute myeloid leukemia (AML) who had received gilteritinib therapy for 43 months. At the time of diagnosis, her karyotype was normal; however, FLT3-ITD, NPM1, DNMT3A, and IDH2 mutations were detected. She received induction therapy with daunorubicin and cytarabine and achieved hematological complete remission (HCR). After attaining HCR, she underwent consolidation therapy with azacytidine or cytarabine, aclarubicin, and granulocyte-colony stimulating factor. However, AML relapsed eight months after the first HCR. FLT3-ITD and NPM1 mutations were persistently positive, and the patient received gilteritinib therapy. Although the FLT3-ITD clone was not detected during gilteritinib treatment, a clone harboring monosomy 7 and CBL mutations emerged. Bone marrow examinations at 15, 24, and 32 months after gilteritinib treatment revealed multi-lineage blood cell dysplasia without an increase in myeloblasts. After 33 months of treatment, gilteritinib was discontinued for two months because to ileus development, and the FLT3-ITD clone was detected again. Gilteritinib treatment was restarted, and FLT3-ITD became negative. Our analysis demonstrated that: (1) hematopoiesis derived from gilteritinib-resistant clones was generated by long-term gilteritinib treatment, and (2) FLT3-ITD clones regained clonal dominance in the absence of FLT3 inhibition. These findings suggest that gilteritinib affects the selection of dominant clones during clonal hematopoiesis.Keywords: gilteritinib, FLT3-ITD, CBL, monosomy 7, clonal hematopoiesis

Published
2023

6. Effect of Prior Antibiotic Treatment on Blood Culture in an Outpatient Department of General Internal Medicine: A Retrospective Case–Control Analysis

Author

Hirosawa T, Sakamoto T, Hanai S, Harada Y, and Shimizu T

Subjects
bacteremia, fever, infection, antibacterial agent, antimicrobial, sepsis, Medicine (General), R5-920
Abstract

Takanobu Hirosawa,1 Tetsu Sakamoto,1 Shogo Hanai,2 Yukinori Harada,1 Taro Shimizu1 1Department of Diagnostic and Generalist Medicine, Dokkyo Medical University, Shimotsuga, Tochigi, Japan; 2Departments of Microbiology and Infectious Diseases, Fujita Health University School of Medicine, Aichi, JapanCorrespondence: Takanobu Hirosawa, Department of Diagnostic and Generalist Medicine, Dokkyo Medical University, 880 Kitakobayashi, Mibu-cho, Shimotsuga, Tochigi, 321-0293, Japan, Tel +81 282 87 2498, Fax +81 282 87 2502, Email hirosawa@dokkyomed.ac.jpPurpose: The effect of antibiotics administered before blood cultures performed in general internal medicine outpatient settings is not well known.Patients and Methods: We conducted a retrospective case–control study including adult patients who underwent blood cultures in the general internal medicine outpatient department of a Japanese university hospital between 2016 and 2022. Patients with positive blood cultures were included as cases and matched patients with negative blood cultures were included as controls. Univariable and multivariable logistic regression analyses were performed.Results: A total of 200 patients and 200 controls were included. Antibiotics were administered prior to blood culture in 20% of patients (79/400). Oral antibiotics were prescribed to 69.6% of the prior antibiotics (55/79). Prior antibiotic use was significantly lower among patients with positive than negative blood cultures (13.5% vs 26.0%, p = 0.002) and was an independent predictive factor in univariable (odds ratio, 0.44; 95% confidence interval, 0.26– 0.73; p = 0.002) and multivariable (adjusted odds ratio, 0.31; 95% confidence interval, 0.15– 0.63; p = 0.002) logistic regression models for positive blood culture. The area under the receiver operating characteristic (AUROC) curve of the multivariable model for predicting positive blood cultures was 0.86.Conclusion: There was a negative correlation between prior antibiotic use and positive blood cultures in the general internal medicine outpatient department. Therefore, physicians should interpret the negative results of blood cultures performed after the administration of antibiotics with care.Keywords: bacteremia, fever, infection, antibacterial agent, antimicrobial, sepsis

Published
2023

8. Survey of Inpatient Consultations with General Internal Medicine Physicians in a Tertiary Hospital: A Retrospective Observational Study

Author

Kawamura R, Harada Y, Yokose M, Hanai S, Suzuki Y, and Shimizu T

Subjects
diagnosis, diagnostic excellence, consultation, consultative medicine, hospital admission, Medicine (General), R5-920
Abstract

Ren Kawamura, Yukinori Harada, Masashi Yokose, Shogo Hanai, Yudai Suzuki, Taro Shimizu Department of Diagnostic and Generalist Medicine, Dokkyo Medical University Hospital, Mibu, Tochigi, JapanCorrespondence: Taro Shimizu, Department of Diagnostic and Generalist Medicine, Dokkyo Medical University Hospital, 880 Kitakobayashi, Shimotsuga, Mibu, Tochigi, 321-0293, Japan, Tel +8128286-1111, Email shimizutaro7@gmail.comPurpose: The general internal medicine (GIM) department can be an effective diagnostic coordinator for undiagnosed outpatients. We investigated the contribution of GIM consultations to the diagnosis of patients admitted to specialty departments in hospitals in Japan that have not yet adopted a hospitalist system.Patients and Methods: This single-center, retrospective observational study was conducted at a university hospital in Japan. GIM consultations from other departments on inpatients aged ≥ 20 years, from April 2016 to March 2021, were included. Data were extracted from electronic medical records, and consultation purposes were categorized into diagnosis, treatment, and diagnosis and treatment. The primary outcome was new diagnosis during hospitalization for patients with consultation purpose of diagnosis or diagnosis and treatment. The secondary outcomes were the purposes of consultation with the Diagnostic and Generalist Medicine department.Results: In total, 342 patients were included in the analysis. The purpose of the consultations was diagnosis for 253 patients (74%), treatment for 60 (17.5%), and diagnosis and treatment for 29 patients (8.5%). In 282 consultations for diagnosis and diagnosis and treatment, 179 new diagnoses were established for 162 patients (57.5%, 95% confidence interval [CI], 51.5– 63.3).Conclusion: The GIM department can function as a diagnostic consultant for inpatients with diagnostic problems admitted to other specialty departments in hospitals where hospitalist or other similar systems are not adopted.Keywords: diagnosis, diagnostic excellence, consultation, consultative medicine, hospital admission

Published
2023

9. Half-metallicity of Mn2VAl ferrimagnet revealed by resonant inelastic soft x-ray scattering under magnetic field

Author

Umetsu, R. Y., Fujiwara, H., Nagai, K., Nakatani, Y., Kawada, M., Sekiyama, A., Kuroda, F., Fujii, H., Oguchi, T., Harada, Y., Miyawaki, J., and Suga, S.

Subjects
Condensed Matter - Materials Science
Abstract

Detailed information on the electronic states of both V and Mn 3d electrons in the ferrimagnet Mn2VAl is obtained by the bulk sensitive resonant inelastic soft x-ray scattering (SX-RIXS) excited with the circularly polarized light under an external magnetic field for the first time. The results under the V L-edge excitation have revealed the negligible partial density of states (PDOS) of the V 3d states around the Fermi energy as well as their rather localized character. Under the Mn L-edge excitation, on the other hand, the spectra are dominated by fluorescence with clear magnetic circular dichroism with noticeable excitation photon energy dependence. Compared with the theoretical prediction of the RIXS spectra based on the density-functional-theory band structure calculation, an itinerant, spin-dependent character of the Mn 3d states and decays of the Mn 2p core states are confirmed in consistence with the half-metallicity of the Mn 3d states.

Published
2018
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10. Effectual Diagnostic Approach: A New Strategy to Achieve Diagnostic Excellence in High Diagnostic Uncertainty

Author

Amano M, Harada Y, and Shimizu T

Subjects
diagnostic excellence, diagnostic uncertainty, diagnostic error, effectuation, co-creation, Medicine (General), R5-920
Abstract

Masayuki Amano,1,2 Yukinori Harada,2 Taro Shimizu2 1Department of Generalist Medicine, Minaminara General Medical Center, Oyodo, Nara, Japan; 2Department of Diagnostic and Generalist Medicine, Dokkyo Medical University Hospital, Mibu, Tochigi, JapanCorrespondence: Taro Shimizu, Department of Diagnostic and Generalist Medicine, Dokkyo Medical University Hospital, 880, Kitakobayashi, Shimotsuga, Mibu, 321-0923, Japan, Tel +81-282-86-1111, Fax +81-282-86-4775, Email shimizutaro7@gmail.comAbstract: The accumulation of optimal decision-making is vital to achieving diagnostic excellence and preventing diagnostic errors. Diagnostic uncertainty (DU) determines the difficulty of each team member’s decision-making process, including the patient, care partners, physicians, and healthcare professionals. The diagnostic approach in the low DU is already available, while the one in the high DU still needs to be clarified. In cognitive science, Sarasvathy et al established “effectuation”, a theory of decision-making under the high-uncertainty condition, by analyzing how outstanding entrepreneurs make decisions when the future is unpredictable. Based on this theory, we developed the “effectual diagnostic approach (EDA).” This simple approach allows patients and physicians to “set” problems co-creatively, emerging the outlines of the clusters of health issues under high DU conditions. After DU declines enough, the traditional problem-solving approach will help the diagnostic team achieve the patient’s well-being. EDA will offer us a guiding principle for action in the high DU. The co-creation of the “patient as an entrepreneur” with the “physician as a co-founder” will contribute to achieving diagnostic excellence.Keywords: diagnostic excellence, diagnostic uncertainty, diagnostic error, effectuation, co-creation

Published
2022

11. Outcomes of General Internal Medicine Consultations for Diagnosis from Specialists in a Tertiary Hospital: A Retrospective Observational Study

Author

Yokose M, Harada Y, Hanai S, Tomiyama S, and Shimizu T

Subjects
consultation, specialists, diagnostic error, diagnostic excellence, diagnostic uncertainty, Medicine (General), R5-920
Abstract

Masashi Yokose, Yukinori Harada, Shogo Hanai, Shusaku Tomiyama, Taro Shimizu Department of Diagnostic and Generalist Medicine, Dokkyo Medical University Hospital, Mibu, Tochigi, 321-0293, JapanCorrespondence: Taro Shimizu, Department of Diagnostic and Generalist Medicine, Dokkyo Medical University Hospital, Kitakobayashi 880, Shimotsuga, Mibu, Tochigi, 321-0293, Japan, Tel +81 282 86-1111, Email shimizutaro7@gmail.comPurpose: The data on the diagnostic contribution of general internal medicine (GIM) consultations for undiagnosed health problems from specialists are scarce. This study aims to explore the role of generalists as diagnostic medicine consultants in tertiary care settings.Patients and Methods: We conducted a retrospective observational study at a Japanese university hospital. GIM consultations for diagnosis from other departments on outpatients aged ≧ 20 years from January 2018 to December 2020 were included. Data were extracted from electronic medical records. The primary outcome was new diagnosis rates. The secondary outcomes were new diagnosis rates with clinical significance and clinical outcomes at 90 days from the index visit.Results: A total of 328 patients were included. The top five consulting departments were orthopedics (17.0%), cardiovascular (10.3%), otorhinolaryngology (8.8%), neurology (8.8%), and gastroenterology (7.9%). GIM identified 456 chief complaints (CCs), and the top five were fever (10.9%), abnormal laboratory results (8.3%), fatigue (5.9%), and pain (7.4%) or numbness (4.6%) in the extremities. There were 139 (104/328 patients: 31.8%) specialty consultations from GIM, and the top five departments were rheumatology (21.1%), gastroenterology (19.2%), orthopedics (9.6%), psychiatry (9.6%), and neurology (9.6%). In total, 277 new diagnoses were established in 232 patients (70.7%), and 203 patients had new diagnoses with clinical significance (61.8%). Clinical outcomes at 90 days from the time of the index visit were resolution/improvement (60.7%), unchanged/worsened (22.3%), and unknown (17.0%).Conclusion: Over 70% of GIM consultations from other departments established new diagnoses with favorable outcomes in > 60% of the patients.Keywords: consultation, specialists, diagnostic error, diagnostic excellence, diagnostic uncertainty

Published
2022

12. The Clinical and Biological Manifestations in Women with Iron Deficiency Without Anemia Compared to Iron Deficiency Anemia in a General Internal Medicine Setting: A Retrospective Cohort Study

Author

Hirosawa T, Hayashi A, Harada Y, and Shimizu T

Subjects
women, hemoglobin, iron deficiency without anemia, serum ferritin, Medicine (General), R5-920
Abstract

Takanobu Hirosawa, Arisa Hayashi, Yukinori Harada, Taro Shimizu Department of Diagnostic and Generalist Medicine, Dokkyo Medical University, Tochigi, JapanCorrespondence: Taro Shimizu, Department of Diagnostic and Generalist Medicine, Dokkyo Medical University, 880 Kitakobayashi, Mibu-cho, Shimotsuga, Tochigi, 321-0293, Japan, Tel + 81 282 87 2498, Fax + 81-282-87-2502, Email shimizu7@dokkyomed.ac.jpPurpose: The clinical presentation of iron deficiency is not well understood. We aimed to identify the clinical manifestations of iron deficiency without anemia in women.Patients and Methods: We conducted a retrospective cohort study of women who visited the general internal medicine outpatient department of a university hospital in Japan between 2016 and 2022. Women who were prescribed iron supplements were included in the study. Anemia was defined as hemoglobin levels below 12 g/dl. Iron deficiency was defined as serum ferritin levels < 30.0 μg/l. The primary outcome was the difference in symptoms between patients with iron deficiency with and without anemia. The secondary outcome was the ratio of symptom, hemoglobin, and serum ferritin improvement (levels > 30.0 μg/l after treatment), comparing the measurements at the beginning and after supplementation.Results: A total of 147 women were included in the final analysis. There were no significant differences in the initial symptoms and the ratio of symptom improvement between the groups. Compared to patients with iron deficiency anemia, patients with iron deficiency without anemia had high initial serum ferritin levels (14.8 vs 7.1 μg/l, p< 0.001), and hemoglobin (13.2 vs 9.9 g/dl, p< 0.001). Iron supplements significantly improved the serum ferritin level in two groups and the hemoglobin in iron deficiency anemia. After treatment, iron deficiency without anemia still had high serum ferritin levels (37.7 vs 28.2 μg/l, p=0.017) and hemoglobin (13.3 vs 12.3 g/dl, p < 0.001).Conclusion: There were no differences in any of the investigated symptoms and the ratio of the symptom improvement depending on the anemic state in iron deficiency. After iron supplementation, the serum ferritin levels in the iron deficiency without anemia group improved. Hemoglobin and serum ferritin in iron deficiency without anemia were still highly comparable to that of iron deficiency anemia.Keywords: women, hemoglobin, iron deficiency without anemia, serum ferritin

Published
2022

13. A fully automated novel urine cytology support artificial intelligence system for the prediction of histological high-grade urothelial carcinoma: External validation study

Author

Kaneko, M., primary, Harada, Y., additional, Tsuji, K., additional, Paralkar, D., additional, Fujihara, A., additional, Ueno, K., additional, Nakanishi, M., additional, Konishi, E., additional, Takamatsu, T., additional, Horiguchi, G., additional, Teramukai, S., additional, Ito-Ihara, T., additional, Abreu, A.L., additional, and Ukimura, O., additional

Published
2024
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14. BepiColombo mission confirms stagnation region of Venus and reveals its large extent

Author

Persson, M., Aizawa, S., André, N., Barabash, S., Saito, Y., Harada, Y., Heyner, D., Orsini, S., Fedorov, A., Mazelle, C., Futaana, Y., Hadid, L. Z., Volwerk, M., Collinson, G., Sanchez-Cano, B., Barthe, A., Penou, E., Yokota, S., Génot, V., Sauvaud, J. A., Delcourt, D., Fraenz, M., Modolo, R., Milillo, A., Auster, H.-U., Richter, I., Mieth, J. Z. D., Louarn, P., Owen, C. J., Horbury, T. S., Asamura, K., Matsuda, S., Nilsson, H., Wieser, M., Alberti, T., Varsani, A., Mangano, V., Mura, A., Lichtenegger, H., Laky, G., Jeszenszky, H., Masunaga, K., Signoles, C., Rojo, M., and Murakami, G.

Published
2022
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15. LatHyS global hybrid simulation of the BepiColombo second Venus flyby

Author

Aizawa, S., Persson, M., Menez, T., André, N., Modolo, R., Génot, V., Sanchez-Cano, B., Volwerk, M., Chaufray, J.-Y., Baskevitch, C., Heyner, D., Saito, Y., Harada, Y., Leblanc, F., Barthe, A., Penou, E., Fedorov, A., Sauvaud, J.-A., Yokota, S., Auster, U., Richter, I., Mieth, J., Horbury, T.S., Louarn, P., Owen, C.J., and Murakami, G.

Published
2022
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16. The Space Physics Environment Data Analysis System (SPEDAS).

Author

Angelopoulos, V, Cruce, P, Drozdov, A, Grimes, EW, Hatzigeorgiu, N, King, DA, Larson, D, Lewis, JW, McTiernan, JM, Roberts, DA, Russell, CL, Hori, T, Kasahara, Y, Kumamoto, A, Matsuoka, A, Miyashita, Y, Miyoshi, Y, Shinohara, I, Teramoto, M, Faden, JB, Halford, AJ, McCarthy, M, Millan, RM, Sample, JG, Smith, DM, Woodger, LA, Masson, A, Narock, AA, Asamura, K, Chang, TF, Chiang, C-Y, Kazama, Y, Keika, K, Matsuda, S, Segawa, T, Seki, K, Shoji, M, Tam, SWY, Umemura, N, Wang, B-J, Wang, S-Y, Redmon, R, Rodriguez, JV, Singer, HJ, Vandegriff, J, Abe, S, Nose, M, Shinbori, A, Tanaka, Y-M, UeNo, S, Andersson, L, Dunn, P, Fowler, C, Halekas, JS, Hara, T, Harada, Y, Lee, CO, Lillis, R, Mitchell, DL, Argall, MR, Bromund, K, Burch, JL, Cohen, IJ, Galloy, M, Giles, B, Jaynes, AN, Le Contel, O, Oka, M, Phan, TD, Walsh, BM, Westlake, J, Wilder, FD, Bale, SD, Livi, R, Pulupa, M, Whittlesey, P, DeWolfe, A, Harter, B, Lucas, E, Auster, U, Bonnell, JW, Cully, CM, Donovan, E, Ergun, RE, Frey, HU, Jackel, B, Keiling, A, Korth, H, McFadden, JP, Nishimura, Y, Plaschke, F, Robert, P, Turner, DL, Weygand, JM, Candey, RM, Johnson, RC, Kovalick, T, Liu, MH, McGuire, RE, and Breneman, A

Subjects
Geospace science, Ionospheric physics, Magnetospheric physics, Planetary magnetospheres, Solar wind, Space plasmas, Solarwind, Astronomical and Space Sciences, Astronomy & Astrophysics
Abstract

With the advent of the Heliophysics/Geospace System Observatory (H/GSO), a complement of multi-spacecraft missions and ground-based observatories to study the space environment, data retrieval, analysis, and visualization of space physics data can be daunting. The Space Physics Environment Data Analysis System (SPEDAS), a grass-roots software development platform (www.spedas.org), is now officially supported by NASA Heliophysics as part of its data environment infrastructure. It serves more than a dozen space missions and ground observatories and can integrate the full complement of past and upcoming space physics missions with minimal resources, following clear, simple, and well-proven guidelines. Free, modular and configurable to the needs of individual missions, it works in both command-line (ideal for experienced users) and Graphical User Interface (GUI) mode (reducing the learning curve for first-time users). Both options have "crib-sheets," user-command sequences in ASCII format that can facilitate record-and-repeat actions, especially for complex operations and plotting. Crib-sheets enhance scientific interactions, as users can move rapidly and accurately from exchanges of technical information on data processing to efficient discussions regarding data interpretation and science. SPEDAS can readily query and ingest all International Solar Terrestrial Physics (ISTP)-compatible products from the Space Physics Data Facility (SPDF), enabling access to a vast collection of historic and current mission data. The planned incorporation of Heliophysics Application Programmer's Interface (HAPI) standards will facilitate data ingestion from distributed datasets that adhere to these standards. Although SPEDAS is currently Interactive Data Language (IDL)-based (and interfaces to Java-based tools such as Autoplot), efforts are under-way to expand it further to work with python (first as an interface tool and potentially even receiving an under-the-hood replacement). We review the SPEDAS development history, goals, and current implementation. We explain its "modes of use" with examples geared for users and outline its technical implementation and requirements with software developers in mind. We also describe SPEDAS personnel and software management, interfaces with other organizations, resources and support structure available to the community, and future development plans.Electronic supplementary materialThe online version of this article (10.1007/s11214-018-0576-4) contains supplementary material, which is available to authorized users.

Published
2019

19. Tensile-Strain Dependent Spin States in Epitaxial LaCoO$_3$ Thin Films

Author

Yokoyama, Y., Yamasaki, Y., Taguchi, M., Hirata, Y., Takubo, K., Miyawaki, J., Harada, Y., Asakura, D., Fujioka, J., Nakamura, M., Daimon, H., Kawasaki, M., Tokura, Y., and Wadati, H.

Subjects
Condensed Matter - Strongly Correlated Electrons
Abstract

The spin states of Co$^{3+}$ ions in perovskite-type LaCoO$_3$, governed by complex interplay between the electron-lattice interactions and the strong electron correlations, still remain controversial due to the lack of experimental techniques which can detect directly. In this letter, we revealed the tensile-strain dependence of spin states, $i. e.$ the ratio of the high- and low-spin states, in epitaxial thin films and a bulk crystal of LaCoO$_3$ via resonant inelastic soft x-ray scattering. The tensile-strain as small as 1.0% was found to realize different spin states from that in the bulk., Comment: 5 pages, 4 figures

Published
2017
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20. Raman and fluorescence contributions to resonant inelastic soft x-ray scattering on LaAlO$_3$/SrTiO$_3$ heterostructures

Author

Pfaff, F., Fujiwara, H., Berner, G., Yamasaki, A., Niwa, H., Kiuchi, H., Gloskovskii, A., Drube, W., Kirilmaz, O., Sekiyama, A., Miyawaki, J., Harada, Y., Suga, S., Sing, M., and Claessen, R.

Subjects
Condensed Matter - Materials Science
Abstract

We present a detailed study of the Ti 3$d$ carriers at the interface of LaAlO$_3$/SrTiO$_3$ heterostructures by high-resolution resonant inelastic soft x-ray scattering (RIXS), with special focus on the roles of overlayer thickness and oxygen vacancies. Our measurements show the existence of interfacial Ti 3$d$ electrons already below the critical thickness for conductivity and an increase of the total interface charge up to a LaAlO$_3$ overlayer thickness of 6 unit cells before it levels out. By comparing stoichiometric and oxygen deficient samples we observe strong Ti 3$d$ charge carrier doping by oxygen vacancies. The RIXS data combined with photoelectron spectroscopy and transport measurements indicate the simultaneous presence of localized and itinerant charge carriers. However, it is demonstrated that the relative amount of localized and itinerant Ti $3d$ electrons in the ground state cannot be deduced from the relative intensities of the Raman and fluorescence peaks in excitation energy dependent RIXS measurements, in contrast to previous interpretations. Rather, we attribute the observation of either the Raman or the fluorescence signal to the spatial extension of the intermediate state reached in the RIXS excitation process., Comment: 9 pages, 6 figures

Published
2017
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21. Electronic Structure and Magnetic Properties of Half-metallic Ferrimagnet Mn$_{2}$VAl Probed by Soft X-ray Spectroscopies

Author

Nagai, K., Fujiwara, H., Aratani, H., Fujioka, S., Yomosa, H., Nakatani, Y., Kiss, T., Sekiyama, A., Kuroda, F., Fujii, H., Oguchi, T., Tanaka, A., Miyawaki, J., Harada, Y., Takeda, Y., Saitoh, Y., Suga, S., and Umetsu, R. Y.

Subjects
Condensed Matter - Strongly Correlated Electrons
Abstract

We have studied the electronic structure of ferrimagnetic Mn2VAl single crystal by means of soft X-ray absorption spectroscopy (XAS), X-ray absorption magnetic circular dichroism (XMCD) and resonant soft X-ray inelastic scattering (RIXS). We have successfully observed the XMCD signals for all constitute elements, supporting the spin polarized states at the Fermi level. The Mn $L_{2,3}$ XAS and XMCD spectra are reproduced by the spectral simulation based on density-functional theory (DFT), indicating itinerant character of the Mn 3d states. On the other hand, V $3d$ electrons are rather localized since the ionic model can qualitatively explain the V $L_{2,3}$ XAS and XMCD spectra as well as the local dd excitation revealed by V $L_3$ RIXS., Comment: 9 pages, 9 figures

Published
2017
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22. Observation of a dispersive charge mode in hole-doped cuprates using resonant inelastic x-ray scattering at the oxygen K edge

Author

Ishii, K., Tohyama, T., Asano, S., Sato, K., Fujita, M., Wakimoto, S., Tustsui, K., Sota, S., Miyawaki, J., Niwa, H., Harada, Y., Pelliciari, J., Huang, Y., Schmitt, T., Yamamoto, Y., and Mizuki, J.

Subjects
Condensed Matter - Strongly Correlated Electrons
Abstract

We investigate electronic excitations in La2-x(Br,Sr)xCuO4 using resonant inelastic x-ray scattering (RIXS) at the oxygen K edge. RIXS spectra of the hole-doped cuprates show clear momentum dependence below 1 eV. The spectral weight exhibits positive dispersion and shifts to higher energy with increasing hole concentration. Theoretical calculation of the dynamical charge structure factor on oxygen orbitals in a three-band Hubbard model is consistent with the experimental observation of the momentum and doping dependence, and therefore the dispersive mode is ascribed to intraband charge excitations which have been observed in electron-doped cuprates., Comment: 6 pages, 3 figures

Published
2017
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23. Structure and dynamics of the Hermean magnetosphere revealed by electron observations from the Mercury electron analyzer after the first three Mercury flybys of BepiColombo.

Author

Rojo, M., André, N., Aizawa, S., Sauvaud, J.-A., Saito, Y., Harada, Y., Fedorov, A., Penou, E., Barthe, A., Persson, M., Yokota, S., Mazelle, C., Hadid, L. Z., Delcourt, D., Fontaine, D., Fränz, M., Katra, B., Krupp, N., and Murakami, G.

Subjects
NATURAL satellites, SOLAR oscillations, ELECTRON density, ELECTRON plasma, MAGNETOSPHERE
Abstract

Context. The Mercury electron analyzer (MEA) obtained new electron observations during the first three Mercury flybys by BepiColombo on October 1, 2021 (MFB1), June 23 , 2022 (MFB2), and June 19, 2023 (MFB3). BepiColombo entered the dusk side magnetotail from the flank magnetosheath in the northern hemisphere, crossed the Mercury solar orbital equator around midnight in the magnetotail, traveled from midnight to dawn in the southern hemisphere near the closest approach, and exited from the post-dawn magnetosphere into the dayside magnetosheath. Aims. We aim to identify the magnetospheric boundaries and describe the structure and dynamics of the electron populations observed in the various regions explored along the flyby trajectories. Methods. We derive 4s time resolution electron densities and temperatures from MEA observations. We compare and contrast our new BepiColombo electron observations with those obtained from the Mariner 10 scanning electron spectrometer (SES) 49 yr ago. Results. A comparison to the averaged magnetospheric boundary crossings of MESSENGER indicates that the magnetosphere of Mercury was compressed during MFB1, close to its average state during MFB2, and highly compressed during MFB3. Our new MEA observations reveal the presence of a wake effect very close behind Mercury when BepiColombo entered the shadow region, a significant dusk-dawn asymmetry in electron fluxes in the nightside magnetosphere, and strongly fluctuating electrons with energies above 100s eV in the dawnside magnetosphere. Magnetospheric electron densities and temperatures are in the range of 10–30 cm−3 and above a few 100s eV in the pre-midnight-sector, and in the range of 1–100 cm−3 and well below 100 eV in the post-midnight sector, respectively. Conclusions. The MEA electron observations of different solar wind properties encountered during the first three Mercury flybys reveal the highly dynamic response and variability of the solar wind-magnetosphere interactions at Mercury. A good match is found between the electron plasma parameters derived by MEA in the various regions of the Hermean environment and similar ones derived in a few cases from other instruments on board BepiColombo. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Spacecraft Outgassing Observed by the BepiColombo Ion Spectrometers

Author

Fränz, M., primary, Rojo, M., additional, Cornet, T., additional, Hadid, L. Z., additional, Saito, Y., additional, André, N., additional, Varsani, A., additional, Schmid, D., additional, Krüger, H., additional, Krupp, N., additional, Delcourt, D., additional, Katra, B., additional, Harada, Y., additional, Yokota, S., additional, Verdeil, C., additional, Aizawa, S., additional, Millilo, A., additional, Orsini, S., additional, Mangano, V., additional, Fiethe, B., additional, Benkhoff, J., additional, and Murakami, G., additional

Published
2024
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28. Expression of Substance P and Nerve Growth Factor in Degenerative Long Head of Biceps Tendon in Patients with Painful Rotator Cuff Tear

Author

Izumi M, Harada Y, Kajita Y, Muramatsu Y, Morimoto T, Morisawa Y, Iwahori Y, and Ikeuchi M

Subjects
long head of biceps tendon, pain, tendinopathy: substance p, nerve growth factor, pressure pain threshold, Medicine (General), R5-920
Abstract

Masashi Izumi,1 Yohei Harada,2,3 Yukihiro Kajita,2 Yoshitaka Muramatsu,2,4 Toru Morimoto,1 Yutaka Morisawa,5 Yusuke Iwahori,2,6 Masahiko Ikeuchi1 1Department of Orthopaedic Surgery, Kochi Medical School, Kochi University, Nankoku-City, Japan; 2Department of Orthopaedic Surgery, Aichi Medical University, Nagakute, Japan; 3Department of Orthopaedic Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan; 4Department of Orthopaedic Surgery, Saiseikai Futsukaichi Hospital, Futsukaichi, Japan; 5Department of Orthopaedic Surgery, Aki General Hospital, Aki, Japan; 6Department of Orthopaedic Surgery, Sports Medicine and Joint Center, Asahi Hospital, Kasugai, JapanCorrespondence: Masashi IzumiDepartment of Orthopaedic Surgery, Kochi Medical School, Kochi University, 185-1 Kohasu, Oko-cho, Nankoku-City, Kochi Pref, 783-8505, JapanTel +81 88-880-2386Fax +81 88-880-2388Email izumim@kochi-u.ac.jpPurpose: Degenerative long head of biceps tendon (LHBT) has been recognized as a notable pain source in patients with rotator cuff tear (RCT). Tenotomy or tenodesis of LHBT is frequently indicated together with arthroscopic rotator cuff repair (ARCR) aiming for complete pain relief; however, it has not been fully investigated whether resected LHBT is really a source of pain. The purpose of this study was to investigate expression levels of pain-associated mediators in LHBT and its association with preoperative pain profiles.Methods: Twenty-seven RCT patients who underwent ARCR with LHBT resection were included. Each LHBT was resected due to its abnormal arthroscopic findings including tenosynovitis, hypertrophy, and partial tear. Worst macroscopic lesion of the LHBT was obtained, and expression levels of substance P (SP) and nerve growth factor (NGF) were evaluated using enzyme-linked immunosorbent assay (ELISA). Ten healthy knee flexor tendons were analyzed as non-degenerative samples. Preoperatively, subjective shoulder pain VAS and pain duration were investigated. Conventional LHBT pain provocation tests (Speed, Yergason, O’Brien) were performed. Pressure pain threshold (PPT) of bilateral LHBT on the groove was recorded.Results: Levels of SP and NGF expression were significantly higher compared with non-degenerative tendons (P< 0.01). Shoulder pain VAS and pain duration were not directly associated with SP and NGF expression level. Patients with positive O’Brien test expressed greater SP than negative patients (P=0.001). Significant negative correlation between the PPT ratio (ipsilateral/contralateral) and SP expression level was observed (r=− 0.453, P=0.034).Conclusion: Greater expression of SP and NGF in degenerative LHBT supported our hypothesis that it would be a pain source in RCT patients. SP was likely to be expressed highly in patients with localized pressure pain hypersensitivity and positive O’Brien test (ie, altered mechanistic pain profile of LHBT), which may help when considering simultaneous LHBT resection during ARCR.Clinical Registration: UMIN000023943.Keywords: long head of biceps tendon, pain, tendinopathy, substance P, nerve growth factor, pressure pain threshold

Published
2021

29. Resonant inelastic x-ray scattering study of entangled spin-orbital excitations in superconducting PrFeAsO0.7

Author

Nomura, T., Harada, Y., Niwa, H., Ishii, K., Ishikado, M., Shamoto, S., and Jarrige, I.

Subjects
Condensed Matter - Strongly Correlated Electrons, Condensed Matter - Superconductivity
Abstract

Low-energy electron excitation spectra were measured on a single crystal of a typical iron-based superconductor PrFeAsO$_{0.7}$ using resonant inelastic X-ray scattering (RIXS) at the Fe-$L_3$ edge. Characteristic RIXS features are clearly observed around 0.5, 1-1.5 and 2-3 eV energy losses. These excitations are analyzed microscopically with theoretical calculations using a 22-orbital model derived from first-principles electronic structure calculation. Based on the agreement with the experiment, the RIXS features are assigned to Fe-$d$ orbital excitations which, at low energies, are accompanied by spin flipping and dominated by Fe $d_{yz}$ and $d_{xz}$ orbital characters. Furthermore, our calculations suggest dispersive momentum dependence of the RIXS excitations below 0.5 eV, and predict remarkable splitting and merging of the lower-energy excitations in momentum space. Those excitations, which were not observed in the present experiment, highlight the potential of RIXS with an improved energy resolution to unravel new details of the electronic structure of the iron-based superconductors., Comment: 12 pages, 6 figures

Published
2016
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30. Spatially resolved electronic structure of an isovalent nitrogen center in GaAs

Author

Plantenga, R. C., Kortan, V. R., Kaizu, T., Harada, Y., Kita, T., Flatté, M. E., and Koenraad, P. M.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

Small numbers of nitrogen dopants dramatically modify the electronic properties of GaAs, generating very large shifts in the conduction-band energies with nonlinear concentration dependence, and impurity-associated spatially-localized resonant states within the conduction band. Cross-sectional scanning tunneling microscopy provides the local electronic structure of single nitrogen dopants at the (110) GaAs surface, yielding highly anisotropic spatial shapes when the empty states are imaged. Measurements of the resonant states relative to the GaAs surface states and their spatial extent allow an unambiguous assignment of specific features to nitrogen atoms at different depths below the cleaved (110) surface. Multiband tight binding calculations around the resonance energy of nitrogen in the conduction band match the imaged features. The spatial anisotropy is attributed to the tetrahedral symmetry of the bulk lattice. Additionally, the voltage dependence of the electronic contrast for two features in the filled state imaging suggest these features could be related to a locally modified surface state.

Published
2016
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31. Interface electronic structure at the topological insulator - ferrimagnetic insulator junction

Author

Kubota, Y., Murata, K., Miyawaki, J., Ozawa, K., Onbasli, M. C., Shirasawa, T., Feng, B., Yamamoto, Sh., Liu, R. -Y., Yamamoto, S., Mahatha, S. K., Sheverdyaeva, P., Moras, P., Ross, C. A., Suga, S., Harada, Y., Wang, K. L., and Matsuda, I.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Materials Science
Abstract

An interface electron state at the junction between a three-dimensional topological insulator (TI) film of Bi2Se3 and a ferrimagnetic insulator film of Y3Fe5O12 (YIG) was investigated by measurements of angle-resolved photoelectron spectroscopy and X-ray absorption magnetic circular dichroism (XMCD). The surface state of the Bi2Se3 film was directly observed and localized 3d spin states of the Fe3+ state in the YIG film were confirmed. The proximity effect is likely described in terms of the exchange interaction between the localized Fe 3d electrons in the YIG film and delocalized electrons of the surface and bulk states in the Bi2Se3 film. The Curie temperature (TC) may be increased by reducing the amount of the interface Fe2+ ions with opposite spin direction observable as a pre-edge in the XMCD spectra., Comment: Supplemental Material can be obtained at http://www.geocities.jp/wkmwx935/Supplemental_Material.pdf

Published
2016
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36. The Physics of the B Factories

Author

Bevan, A. J., Golob, B., Mannel, Th., Prell, S., Yabsley, B. D., Abe, K., Aihara, H., Anulli, F., Arnaud, N., Aushev, T., Beneke, M., Beringer, J., Bianchi, F., Bigi, I. I., Bona, M., Brambilla, N., rodzicka, J. B, Chang, P., Charles, M. J., Cheng, C. H., Cheng, H. -Y., Chistov, R., Colangelo, P., Coleman, J. P., Drutskoy, A., Druzhinin, V. P., Eidelman, S., Eigen, G., Eisner, A. M., Faccini, R., Flood, K. T ., Gambino, P., Gaz, A., Gradl, W., Hayashii, H., Higuchi, T., Hulsbergen, W. D., Hurth, T., Iijima, T., Itoh, R., Jackson, P. D., Kass, R., Kolomensky, Yu. G., Kou, E., Križan, P., Kronfeld, A., Kumano, S., Kwon, Y. J., Latham, T. E., Leith, D. W. G. S., Lüth, V., Martinez-Vidal, F., Meadows, B. T., Mussa, R., Nakao, M., Nishida, S., Ocariz, J., Olsen, S. L., Pakhlov, P., Pakhlova, G., Palano, A., Pich, A., Playfer, S., Poluektov, A., Porter, F. C., Robertson, S. H., Roney, J. M., Roodman, A., Sakai, Y., Schwanda, C., Schwartz, A. J., Seidl, R., Sekula, S. J., Steinhauser, M., Sumisawa, K., Swanson, E. S., Tackmann, F., Trabelsi, K., Uehara, S., Uno, S., van der Water, R., Vasseur, G., Verkerke, W., Waldi, R., Wang, M. Z., Wilson, F. F., Zupan, J., Zupanc, A., Adachi, I., Albert, J., Banerjee, Sw., Bellis, M., Ben-Haim, E., Biassoni, P., Cahn, R. N., Cartaro, C., Chauveau, J., Chen, C., Chiang, C. C., Cowan, R., Dalseno, J., Davier, M., Davies, C., Dingfelder, J. C., nard, B. Eche, Epifanov, D., Fulsom, B. G., Gabareen, A. M., Gary, J. W., Godang, R., Graham, M. T., Hafner, A., Hamilton, B., Hartmann, T., Hayasaka, K., Hearty, C., Iwasaki, Y., Khodjamirian, A., Kusaka, A., Kuzmin, A., Lafferty, G. D., Lazzaro, A., Li, J., Lindemann, D., Long, O., Lusiani, A., Marchiori, G., Martinelli, M., Miyabayashi, K., Mizuk, R., Mohanty, G. B., Muller, D. R., Nakazawa, H., Ongmongkolkul, P., Pacetti, S., Palombo, F., Pedlar, T. K., Piilonen, L. E., Pilloni, A., Poireau, V., Prothmann, K., Pulliam, T., Rama, M., Ratcliff, B. N., Roudeau, P., Schrenk, S., Schroeder, T., Schubert, K. R., Shen, C. P., Shwartz, B., Soffer, A., Solodov, E. P., Somov, A., Starič, M., Stracka, S., Telnov, A. V., Todyshev, K. Yu., Tsuboyama, T., Uglov, T., Vinokurova, A., Walsh, J. J., Watanabe, Y., Won, E., Wormser, G., Wright, D. H., Ye, S., Zhang, C. C., Abachi, S., Abashian, A., Abe, N., Abe, R., Abe, T., Abrams, G. S., Adam, I., Adamczyk, K., Adametz, A., Adye, T., Agarwal, A., Ahmed, H., Ahmed, M., Ahmed, S., Ahn, B. S., Ahn, H. S., Aitchison, I. J. R., Akai, K., Akar, S., Akatsu, M., Akemoto, M., Akhmetshin, R., Akre, R., Alam, M. S., Albert, J. N., Aleksan, R., Alexander, J. P., Alimonti, G., Allen, M. T., Allison, J., Allmendinger, T., Alsmiller, J. R. G., Altenburg, D., Alwyn, K. E., An, Q., Anderson, J., Andreassen, R., Andreotti, D., Andreotti, M., Andress, J. C., Angelini, C., Anipko, D., Anjomshoaa, A., Anthony, P. L., Antillon, E. A., Antonioli, E., Aoki, K., Arguin, J. F., Arinstein, K., Arisaka, K., Asai, K., Asai, M., Asano, Y., Asgeirsson, D. J., Asner, D. M., Aso, T., Aspinwall, M. L., Aston, D., Atmacan, H., Aubert, B., Aulchenko, V., Ayad, R., Azemoon, T., Aziz, T., Azzolini, V., Azzopardi, D. E., Baak, M. A., Back, J. J., Bagnasco, S., Bahinipati, S., Bailey, D. S., Bailey, S., Bailly, P., van Bakel, N., Bakich, A. M., Bala, A., Balagura, V., Baldini-Ferroli, R., Ban, Y., Banas, E., Band, H. R., Banerjee, S., Baracchini, E., Barate, R., Barberio, E., Barbero, M., Bard, D. J., Barillari, T., Barlow, N. R., Barlow, R. J., Barrett, M., Bartel, W., Bartelt, J., Bartoldus, R., Batignani, G., Battaglia, M., Bauer, J. M., Bay, A., Beaulieu, M., Bechtle, P., Beck, T. W., Becker, J., Becla, J., Bedny, I., Behari, S., Behera, P. K., Behn, E., Behr, L., Beigbeder, C., Beiline, D., Bell, R., Bellini, F., Bellodi, G., Belous, K., Benayoun, M., Benelli, G., Benitez, J. F., Benkebil, M., Berger, N., Bernabeu, J., Bernard, D., Bernet, R., Bernlochner, F. U., Berryhill, J. W., Bertsche, K., Besson, P., Best, D. S., Bettarini, S., Bettoni, D., Bhardwaj, V., Bhimji, W., Bhuyan, B., Biagini, M. E., Biasini, M., van Bibber, K., Biesiada, J., Bingham, I., Bionta, R. M., Bischofberger, M., Bitenc, U., Bizjak, I., Blanc, F., Blaylock, G., Blinov, V. E., Bloom, E., Bloom, P. C., Blount, N. L., Blouw, J., Bly, M., Blyth, S., Boeheim, C. T., Bomben, M., Bondar, A., Bondioli, M., Bonneaud, G. R., Bonvicini, G., Booke, M., Booth, J., Borean, C., Borgland, A. W., Borsato, E., Bosi, F., Bosisio, L., Botov, A. A., Bougher, J., Bouldin, K., Bourgeois, P., Boutigny, D., Bowerman, D. A., Boyarski, A. M., Boyce, R. F., Boyd, J. T., Bozek, A., Bozzi, C., Bračko, M., Brandenburg, G., Brandt, T., Brau, B., Brau, J., Breon, A. B., Breton, D., Brew, C., Briand, H., Bright-Thomas, P. G., Brigljević, V., Britton, D. I., Brochard, F., Broomer, B., Brose, J., Browder, T. E., Brown, C. L., Brown, C. M., Brown, D. N., Browne, M., Bruinsma, M., Brunet, S., Bucci, F., Buchanan, C., Buchmueller, O. L., Bünger, C., Bugg, W., Bukin, A. D., Bula, R., Bulten, H., Burchat, P. R., Burgess, W., Burke, J. P., Button-Shafer, J., Buzykaev, A. R., Buzzo, A., Cai, Y., Calabrese, R., Calcaterra, A., Calderini, G., Camanzi, B., Campagna, E., Campagnari, C., Capra, R., Carassiti, V., Carpinelli, M., Carroll, M., Casarosa, G., Casey, B. C. K., Cason, N. M., Castelli, G., Cavallo, N., Cavoto, G., Cecchi, A., Cenci, R., Cerizza, G., Cervelli, A., Ceseracciu, A., Chai, X., Chaisanguanthum, K. S., Chang, M. C., Chang, Y. H., Chang, Y. W., Chao, D. S., Chao, M., Chao, Y., Charles, E., Chavez, C. A., Cheaib, R., Chekelian, V., Chen, A., Chen, E., Chen, G. P., Chen, H. F., Chen, J. -H., Chen, J. C., Chen, K. F., Chen, P., Chen, S., Chen, W. T., Chen, X., Chen, X. R., Chen, Y. Q., Cheng, B., Cheon, B. G., Chevalier, N., Chia, Y. M., Chidzik, S., Chilikin, K., Chistiakova, M. V., Cizeron, R., Cho, I. S., Cho, K., Chobanova, V., Choi, H. H. F., Choi, K. S., Choi, S. K., Choi, Y., Choi, Y. K., Christ, S., Chu, P. H., Chun, S., Chuvikov, A., Cibinetto, G., Cinabro, D., Clark, A. R., Clark, P. J., Clarke, C. K., Claus, R., Claxton, B., Clifton, Z. C., Cochran, J., Cohen-Tanugi, J., Cohn, H., Colberg, T., Cole, S., Colecchia, F., Condurache, C., Contri, R., Convert, P., Convery, M. R., Cooke, P., Copty, N., Cormack, C. M., Corso, F. Dal, Corwin, L. A., Cossutti, F., Cote, D., Ramusino, A. Cotta, Cottingham, W. N., Couderc, F., Coupal, D. P., Covarelli, R., Cowan, G., Craddock, W. W., Crane, G., Crawley, H. B., Cremaldi, L., Crescente, A., Cristinziani, M., Crnkovic, J., Crosetti, G., Cuhadar-Donszelmann, T., Cunha, A., Curry, S., D'Orazio, A., Dû, S., Dahlinger, G., Dahmes, B., Dallapiccola, C., Danielson, N., Danilov, M., Das, A., Dash, M., Dasu, S., Datta, M., Daudo, F., Dauncey, P. D., David, P., Davis, C. L., Day, C. T., De Mori, F., De Domenico, G., De Groot, N., De la Vaissière, C., de la Vaissière, Ch., de Lesquen, A., De Nardo, G., de Sangro, R., De Silva, A., DeBarger, S., Decker, F. J., Sanchez, P. del Amo, Del Buono, L., Del Gamba, V., del Re, D., Della Ricca, G., Denig, A. G., Derkach, D., Derrington, I. M., DeStaebler, H., Destree, J., Devmal, S., Dey, B., Di Girolamo, B., Di Marco, E., Dickopp, M., Dima, M. O., Dittrich, S., Dittongo, S., Dixon, P., Dneprovsky, L., Dohou, F., Doi, Y., Doležal, Z., Doll, D. A., Donald, M., Dong, L., Dong, L. Y., Dorfan, J., Dorigo, A., Dorsten, M. P., Dowd, R., Dowdell, J., Drásal, Z., Dragic, J., Drummond, B. W., Dubitzky, R. S., Dubois-Felsmann, G. P., Dubrovin, M. S., Duh, Y. C., Duh, Y. T., Dujmic, D., Dungel, W., Dunwoodie, W., Dutta, D., Dvoretskii, A., Dyce, N., Ebert, M., Eckhart, E. A., Ecklund, S., Eckmann, R., Eckstein, P., Edgar, C. L., Edwards, A. J., Egede, U., Eichenbaum, A. M., Elmer, P., Emery, S., Enari, Y., Enomoto, R., Erdos, E., Erickson, R., Ernst, J. A., Erwin, R. J., Escalier, M., Eschenburg, V., Eschrich, I., Esen, S., Esteve, L., Evangelisti, F., Everton, C. W., Eyges, V., Fabby, C., Fabozzi, F., Fahey, S., Falbo, M., Fan, S., Fang, F., Fanin, C., Farbin, A., Farhat, H., Fast, J. E., Feindt, M., Fella, A., Feltresi, E., Ferber, T., Fernholz, R. E., Ferrag, S., Ferrarotto, F., Ferroni, F., Field, R. C., Filippi, A., Finocchiaro, G., Fioravanti, E., da Costa, J. Firmino, Fischer, P. -A., Fisher, A., Fisher, P. H., Flacco, C. J., Flack, R. L., Flaecher, H. U., Flanagan, J., Flanigan, J. M., Ford, K. E., Ford, W. T., Forster, I. J., Forti, A. C., Forti, F., Fortin, D., Foster, B., Foulkes, S. D., Fouque, G., Fox, J., Franchini, P., Sevilla, M. Franco, Franek, B., Frank, E. D., Fransham, K. B., Fratina, S., Fratini, K., Frey, A., Frey, R., Friedl, M., Fritsch, M., Fry, J. R., Fujii, H., Fujikawa, M., Fujita, Y., Fujiyama, Y., Fukunaga, C., Fukushima, M., Fullwood, J., Funahashi, Y., Funakoshi, Y., Furano, F., Furman, M., Furukawa, K., Futterschneider, H., Gabathuler, E., Gabriel, T. A., Gabyshev, N., Gaede, F., Gagliardi, N., Gaidot, A., Gaillard, J. -M., Gaillard, J. R., Galagedera, S., Galeazzi, F., Gallo, F., Gamba, D., Gamet, R., Gan, K. K., Gandini, P., Ganguly, S., Ganzhur, S. F., Gao, Y. Y., Gaponenko, I., Garmash, A., Tico, J. Garra, Garzia, I., Gaspero, M., Gastaldi, F., Gatto, C., Gaur, V., Geddes, N. I., Geld, T. L., Genat, J. -F., George, K. A., George, M., George, S., Georgette, Z., Gershon, T. J., Gill, M. S., Gillard, R., Gilman, J. D., Giordano, F., Giorgi, M. A., Giraud, P. -F., Gladney, L., Glanzman, T., Glattauer, R., Go, A., Goetzen, K., Goh, Y. M., Gokhroo, G., Goldenzweig, P., Golubev, V. B., Gopal, G. P., Gordon, A., Gorišek, A., Goriletsky, V. I., Gorodeisky, R., Gosset, L., Gotow, K., Gowdy, S. 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P., Treadwell, E., Triggiani, G., Trincaz-Duvoid, S., Trischuk, W., Troost, D., Trunov, A., Tsai, K. L., Tsai, Y. T., Tsujita, Y., Tsukada, K., Tsukamoto, T., Tuggle, J. M., Tumanov, A., Tung, Y. W., Turnbull, L., Turner, J., Turri, M., Uchida, K., Uchida, M., Uchida, Y., Ueki, M., Ueno, K., Ujiie, N., Ulmer, K. A., Unno, Y., Urquijo, P., Ushiroda, Y., Usov, Y., Usseglio, M., Usuki, Y., Uwer, U., Va'vra, J., Vahsen, S. E., Vaitsas, G., Valassi, A., Vallazza, E., Vallereau, A., Vanhoefer, P., van Hoek, W. C., Van Hulse, C., van Winkle, D., Varner, G., Varnes, E. W., Varvell, K. E., Vasileiadis, G., Velikzhanin, Y. S., Verderi, M., Versillé, S., Vervink, K., Viaud, B., Vidal, P. B., Villa, S., Villanueva-Perez, P., Vinograd, E. L., Vitale, L., Vitug, G. M., Voß, C., Voci, C., Voena, C., Volk, A., von Wimmersperg-Toeller, J. H., Vorobyev, V., Vossen, A., Vuagnin, G., Vuosalo, C. O., Wacker, K., Wagner, A. P., Wagner, D. L., Wagner, G., Wagner, M. N., Wagner, S. R., Wagoner, D. 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Z., Yèche, Ch., Yamada, Y., Yamaga, M., Yamaguchi, A., Yamaguchi, H., Yamaki, T., Yamamoto, H., Yamamoto, N., Yamamoto, R. K., Yamamoto, S., Yamanaka, T., Yamaoka, H., Yamaoka, J., Yamaoka, Y., Yamashita, Y., Yamauchi, M., Yan, D. S., Yan, Y., Yanai, H., Yanaka, S., Yang, H., Yang, R., Yang, S., Yarritu, A. K., Yashchenko, S., Yashima, J., Yasin, Z., Yasu, Y., Ye, S. W., Yeh, P., Yi, J. I., Yi, K., Yi, M., Yin, Z. W., Ying, J., Yocky, G., Yokoyama, K., Yokoyama, M., Yokoyama, T., Yoshida, K., Yoshida, M., Yoshimura, Y., Young, C. C., Yu, C. X., Yu, Z., Yuan, C. Z., Yuan, Y., Yumiceva, F. X., Yusa, Y., Yushkov, A. N., Yuta, H., Zacek, V., Zain, S. B., Zallo, A., Zambito, S., Zander, D., Zang, S. L., Zanin, D., Zaslavsky, B. G., Zeng, Q. L., Zghiche, A., Zhang, B., Zhang, J., Zhang, L., Zhang, L. M., Zhang, S. Q., Zhang, Z. P., Zhao, H. W., Zhao, M., Zhao, Z. G., Zheng, Y., Zheng, Y. H., Zheng, Z. P., Zhilich, V., Zhou, P., Zhu, R. Y., Zhu, Y. S., Zhu, Z. M., Zhulanov, V., Ziegler, T., Ziegler, V., Zioulas, G., Zisman, M., Zito, M., Zürcher, D., Zwahlen, N., Zyukova, O., Živko, T., and Žontar, D.

Subjects
High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract

This work is on the Physics of the B Factories. Part A of this book contains a brief description of the SLAC and KEK B Factories as well as their detectors, BaBar and Belle, and data taking related issues. Part B discusses tools and methods used by the experiments in order to obtain results. The results themselves can be found in Part C. Please note that version 3 on the archive is the auxiliary version of the Physics of the B Factories book. This uses the notation alpha, beta, gamma for the angles of the Unitarity Triangle. The nominal version uses the notation phi_1, phi_2 and phi_3. Please cite this work as Eur. Phys. J. C74 (2014) 3026., Comment: 928 pages, version 3 (arXiv:1406.6311v3) corresponds to the alpha, beta, gamma version of the book, the other versions use the phi1, phi2, phi3 notation

Published
2014
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37. Spin and orbital magnetic moments of Fe in the $n$-type ferromagnetic semiconductor (In,Fe)As

Author

Kobayashi, M., Anh, L. D., Hai, P. N., Takeda, Y., Sakamoto, S., Kadono, T., Okane, T., Saitoh, Y., Yamagami, H., Harada, Y., Oshima, M., Tanaka, M., and Fujimori, A.

Subjects
Condensed Matter - Materials Science
Abstract

The electronic and magnetic properties of Fe atoms in the ferromagnetic semiconductor (In,Fe)As codoped with Be have been studied by x-ray absorption spectroscopy (XAS) and x-ray magnetic circular dichroism (XMCD) at the Fe $L_{2,3}$ edge. The XAS and XMCD spectra showed simple spectral line shapes similar to Fe metal, but the ratio of the orbital and spin magnetic moments ($M_\mathrm{orb}$/$M_\mathrm{spin}$) estimated using the XMCD sum rules was significantly larger than that of Fe metal, indicating a significant orbital moment of Fe $3d$ electrons in (In,Fe)As:Be. The positive value of $M_\mathrm{orb}$/$M_\mathrm{spin}$ implies that the Fe $3d$ shell is more than half-filled, which arises from the hybridization of the Fe$^{3+}$ ($d^5$) state with the charge-transfer $d^6\underline{L}$ states, where $\underline{L}$ is a ligand hole in the host valence band. The XMCD intensity as a function of magnetic field indicated hysteretic behavior of the superparamagnetic-like component due to discrete ferromagnetic domains., Comment: 4 pages, 2 figures, 1 table

Published
2014
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39. Electronic excitations of magnetic impurity state in diluted magnetic semiconductor (Ga,Mn)As

Author

Kobayashi, M., Niwa, H., Takeda, Y., Fujimori, A., Senba, Y., Ohashi, H., Tanaka, A., Ohya, S., Hai, P. N., Tanaka, M., Harada, Y., and Oshima, M.

Subjects
Condensed Matter - Materials Science
Abstract

The electronic structure of doped Mn in (Ga,Mn)As is studied by resonant inelastic X-ray scattering (RIXS). From configuration-interaction cluster-model calculations, the line shapes of the Mn $L_3$ RIXS spectra can be explained by $d$-$d$ excitations from the Mn$^{3+}$ ground state, dominated by charge-transferred states, rather than a Mn$^{2+}$ ground state. Unlike archetypical $d$-$d$ excitation, the peak widths are broader than the experimental energy resolution. We attribute the broadening to a finite lifetime of the $d$-$d$ excitations, which decay rapidly to electron-hole pairs in the host valence and conduction bands through hybridization of the Mn $3d$ orbital with the ligand band., Comment: 5 pages, 3 figures

Published
2013
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41. Systematic characterization of upper critical fields for MgB$_2$ thin films using the two-band superconducting theory

Author

Noguchi, S., Kuribayashi, A., Ishida, T., Oba, T., Iriuda, H., Yoshizawa, M., Harada, Y., Miki, S., Shimakage, H., Wang, Z., Satoh, K., and Yotsuya, T.

Subjects
Condensed Matter - Superconductivity, Condensed Matter - Strongly Correlated Electrons
Abstract

We present experimental results of the upper critical fields $H_{\rm c2}$ of various MgB$_2$ thin films prepared by the molecular beam epitaxy, multiple-targets sputtering, and co-evaporation deposition apparatus. Experimental data of the $H_{\rm c2}(T)$ are successfully analyzed by applying the Gurevich theory of dirty two-band superconductivity in the case of $D_{\pi}/D_{\sigma}>1$, where $D_{\pi}$ and $D_{\sigma}$ are the intraband electron diffusivities for $\pi$ and $\sigma$ bands, respectively. We find that the parameters obtained from the analysis are strongly correlated to the superconducting transition temperature $T_{\rm c}$ of the films. We also discuss the anormalous narrowing of the transition width at intermediate temperatures confirmed by the magnetoresistance measurements., Comment: 7 pages, 7 figures, submitted to Phys. Rev. B

Published
2008
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42. Atomic-like behaviors and orbital-related Luttinger liquid in carbon nano-peapod quantum dots

Author

Haruyama, J., Mizubayashi, J., Takesue, I., Okazaki, T., Shinohara, H., Harada, Y., and Awano, Y.

Subjects
Condensed Matter - Materials Science
Abstract

We report influence of encapsulated C60 molecules on electron transport in carbon-nanotube peapod quantum dots. We find atomic-like behaviors with doubly degenerate electronic levels, which exist only around ground states, by single electron spectroscopy measured at low back-gate voltages (Vbg). Correlation with presence of nearly free electrons (NFEs) unique to the peapods is discussed. Moreover, we find anomalously high values of power a observed in power laws in conductance versus energy relationships, which are strongly associated with the doubly degenerate levels. It is revealed that the powers originate from Tomonaga-Luttinger liquid via the occupied doubly degenerate levels. Our observations clarify that the encapsulated C60 molecules form doubly degenerate levels only at ground state in peapod quantum dots and do not eliminate a ballistic charge transport., Comment: Submitted on behalf of TIMA Editions (http://irevues.inist.fr/tima-editions)

Published
2007

43. Direct Observation of Site-specific Valence Electronic Structure at Interface: SiO2/Si Interface

Author

Yamashita, Y., Yamamoto, S., Mukai, K., Yoshinobu, J., Harada, Y., Tokushima, T., Takeuchi, 2T., Takata, 2 Y., Shin, S., Akagi, K., and Tsuneyuki, S.

Subjects
Condensed Matter - Materials Science
Abstract

Atom specific valence electronic structures at interface are elucidated successfully using soft x-ray absorption and emission spectroscopy. In order to demonstrate the versatility of this method, we investigated SiO2/Si interface as a prototype and directly observed valence electronic states projected at the particular atoms of the SiO2/Si interface; local electronic structure strongly depends on the chemical states of each atom. In addition we compared the experimental results with first-principle calculations, which quantitatively revealed the interfacial properties in atomic-scale., Comment: 4 pages, 3 figures

Published
2005
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44. Doping Dependent Changes in Nitrogen 2$p$ States in the Diluted Magnetic Semiconductor Ga$_{1-x}$Cr$_{x}$N

Author

Takeuchi, T., Harada, Y., Tokushima, T., Taguchi, M., Takata, Y., Chainani, A., Kim, J. J., Makino, H., Yao, T., Yamamoto, T., Tsukamoto, T., Shin, S., and Kobayashi, K.

Subjects
Condensed Matter - Materials Science
Abstract

We study the electronic structure of the recently discovered diluted magnetic semiconductor Ga$_{1-x}$Cr$_{x}$N ($x$ = 0.01-0.10). A systematic study of the changes in the $occupied$ and $unoccupied$ ligand (N) partial density of states (DOS) of the host lattice is carried out using N 1$s$ soft x-ray emission and absorption spectroscopy, respectively. X-ray absorption measurements confirm the wurtzite N 2$p$ DOS and substitutional doping of Cr into Ga-sites. Coupled changes in the $occupied$ and $unoccupied$ N 2$p$ character DOS of Ga$_{1-x}$Cr$_{x}$N identify states responsible for ferromagnetism consistent with band structure calculations., Comment: 5 pages, 4 figures, submitted to Phys. Rev. B

Published
2004
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45. Anisotropy of superconductivity of as-grown MgB$_2$ thin films by molecular beam epitaxy

Author

Harada, Y., Udsuka, M., Nakanishi, Y., and Yoshizawa, M.

Subjects
Condensed Matter - Superconductivity, Condensed Matter - Materials Science
Abstract

Superconducting thin films of magnesium diboride (MgB$_2$) were prepared on MgO (001) substrate by a molecular beam epitaxy (MBE) method with the co-evaporation conditions of low deposition rate in ultra-high vacuum. The structural and physical properties of the films were studied by RHEED, XRD, XPS, resistivity and magnetization measurements.All films demonstrated superconductivity without use of any post-annealing process.The highest {\it T}$_{c,onset}$ determined by resistivity measurement was about 33K in the present samples.Anisotropic superconducting properties were evaluated by the resistivity and magnetic measurements.We will discuss the anisotropy of superconductivity for as-grown MgB$_2$ thin films., Comment: 15 pages, 8 figures, 1 table, submitted to Journal of Applied Physics

Published
2004

46. Synthesis of as-grown superconducting MgB_2 thin films by molecular beam epitaxy in UHV conditions

Author

Harada, Y., Udsuka, M., Nakanishi, Y., and Yoshizawa, M.

Subjects
Condensed Matter - Superconductivity, Condensed Matter - Materials Science
Abstract

As-grown superconducting MgB_2 thin films have been grown on SrTiO_3(001), MgO(001), and Al_2O_3(0001) substrates by a molecular beam epitaxy (MBE) method with novel co-evaporation conditions of low deposition rate in ultra-high vacuum. The structural and physical properties of the films were studied by RHEED, XRD, electrical resistivity measurements, and SQUID magnetometer. The RHEED patterns indicate three-dimensional growth for MgB_2. The highest T_c determined by resistivity measurement was about 36K in these samples. And a clear Meissner effect below T_c was observed using magnetic susceptibility measurement. We will discuss the influence of B buffer layer on the structural and physical properties., Comment: 9 pages with 4 figures, ISS2003 proceeding

Published
2004
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47. Dynamical symmetry breaking under core excitation in graphite: Polarization correlation in soft X-ray recombination emission

Author

Harada, Y., Tokushima, T., Takata, Y., Takeuchi, T., Kitajima, Y., Tanaka, S., Kayanuma, Y., and Shin, S.

Subjects
Condensed Matter - Materials Science
Abstract

A recombination emission spectrum is applied to study the local lattice distortion due to core excitation in graphite. The recombination emission spectrum reveals a long low-energy tail when the C $1s$ electron is excited to the $\sigma^*$ core exciton state. This indicates a large local lattice distortion around the excited carbon atom within a core hole lifetime ($\sim$10fs). Theoretical calculation based upon an ionic cluster model well reproduces the experiments. The strong polarization correlation between incident and emitted X-rays is conclusive evidence of symmetry breaking in the core exciton state due to coupling with asymmetric vibrational modes., Comment: 9 pages, 4 figures

Published
2003
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48. Layer dependent band dispersion and correlations using tunable Soft X-ray ARPES

Author

Kamakura, N., Takata, Y., Tokushima, T., Harada, Y., Chainani, A., Kobayashi, K., and Shin, S.

Subjects
Condensed Matter - Strongly Correlated Electrons, Condensed Matter - Materials Science
Abstract

Soft X-ray Angle-Resolved Photoemission Spectroscopy is applied to study in-plane band dispersions of Nickel as a function of probing depth. Photon energies between 190 and 780 eV were used to effectively probe up to 3-7 layers. The results show layer dependent band dispersion of the Delta_2 minority-spin band which crosses the Fermi level in 3 or more layers, in contrast to known top 1-2 layers dispersion obtained using ultra-violet rays. The layer dependence corresponds to an increased value of exchange splitting and suggests reduced correlation effects in the bulk compared to the surface., Comment: 7 pages, 3 figures Revised text and figure

Published
2003
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49. Requirement of longer term antiviral therapy in patients with cytomegalovirus anterior uveitis with corneal endothelial cell damage

Author

Harada Y, Fukuda K, Nakahira A, Tada K, Sumi T, and Fukushima A

Subjects
cytomegalovirus, anterior uveitis, corneal endothelial cell, polymerase chain reaction, clinical course, Ophthalmology, RE1-994
Abstract

Yosuke Harada,1,2 Ken Fukuda,1 Asami Nakahira,1 Kentaro Tada,1 Tamaki Sumi,1 Atsuki Fukushima1 1Department of Ophthalmology and Visual Science, Kochi Medical School, Nankoku, Japan; 2Department of Ophthalmology and Visual Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan Background: The aim of the study was to investigate the efficacy of therapy in patients with cytomegalovirus (CMV) anterior uveitis. Patients and methods: We reviewed the records of patients with CMV anterior uveitis who attended our institution between October 2010 and December 2015 and who were confirmed to have CMV DNA in the aqueous humor by polymerase chain reaction analysis. Results: Fourteen immunocompetent patients (10 men and 4 women, total of 17 eyes) were enrolled. The mean ± SD age at the onset of antiviral therapy was 63.1 ± 11.3 years (range, 44–87 years). CMV DNA was not detected in the aqueous humor of 3 patients on initial testing, but it was detected on subsequent analysis. All patients underwent systemic antiviral therapy. Among the patients who were followed up for more than 6 months after starting systemic antiviral therapy, systemic antiviral therapy was successfully terminated in all 4 patients without corneal endothelial loss but had to be continued because of disease recurrence on its termination in 5 of 8 patients (62.5%) with corneal endothelial damage (P = 0.038). Conclusions: Patients with corneal endothelial cell loss are likely to require longer term antiviral therapy than those without endothelial damage. In addition, whereas definitive diagnosis of CMV anterior uveitis requires the detection of CMV DNA in aqueous humor by polymerase chain reaction, one-fifth of patients in the present study tested negative on initial examination. Keywords: cytomegalovirus, anterior uveitis, corneal endothelial cell, polymerase chain reaction, clinical course

Published
2018

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