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3. The clinical significance of the lymph node ratio as a recurrence indicator in ampullary cancer after curative pancreaticoduodenectomy

Author

Hasegawa, Shinichiro, Wada, Hiroshi, Kubo, Masahiko, Mukai, Yosuke, Mikamori, Manabu, Akita, Hirofumi, Matsuura, Norihiro, Kitakaze, Masatoshi, Masuike, Yasunori, Sugase, Takahito, Shinno, Naoki, Kanemura, Takashi, Hara, Hisashi, Sueda, Toshinori, Nishimura, Junichi, Yasui, Masayoshi, Omori, Takeshi, Miyata, Hiroshi, and Ohue, Masayuki

Published
2024
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4. Significance of Comprehensive Analysis of Preoperative Sarcopenia Based on Muscle Mass, Muscle Strength, and Physical Function for the Prognosis of Patients with Esophageal Cancer

Author

Kanemura, Takashi, Takeoka, Tomohira, Sugase, Takahito, Urakawa, Shinya, Masuike, Yasunori, Shinno, Naoki, Hara, Hisashi, Kitakaze, Masatoshi, Kubo, Masahiko, Mukai, Yousuke, Sueda, Toshinori, Hasegawa, Shinichiro, Akita, Hirofumi, Nishimura, Junichi, Wada, Hiroshi, Yasui, Masayoshi, Omori, Takeshi, and Miyata, Hiroshi

Published
2024
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5. A striking elevation of CA19-9 after preoperative therapy negates prognostic benefit from radical surgery in resectable and borderline resectable pancreatic cancer

Author

Akita, Hirofumi, Mukai, Yosuke, Kubo, Masahiko, Takahashi, Hidenori, Hasegawa, Shinichiro, Kitakaze, Masatoshi, Matsuura, Norihiro, Masuike, Yasunori, Sugase, Takahito, Shinno, Naoki, Kanemura, Takashi, Hara, Hisashi, Sueda, Toshinori, Nishimura, Junichi, Yasui, Masayoshi, Omori, Takeshi, Miyata, Hiroshi, Ohue, Masayuki, and Wada, Hiroshi

Published
2024
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9. DUPAN-II normalisation as a biological indicator during preoperative chemoradiation therapy for resectable and borderline resectable pancreatic cancer

Author

Hasegawa, Shinichiro, Takahashi, Hidenori, Akita, Hirofumi, Mukai, Yosuke, Mikamori, Manabu, Asukai, Kei, Yamada, Daisaku, Wada, Hiroshi, Fujii, Yoshiaki, Sugase, Takahito, Yamamoto, Masaaki, Takeoka, Tomohira, Shinno, Naoki, Hara, Hisashi, Kanemura, Takashi, Haraguchi, Naotsugu, Nishimura, Junichi, Matsuda, Chu, Yasui, Masayoshi, Omori, Takeshi, Miyata, Hiroshi, Ohue, Masayuki, Ishikawa, Osamu, and Sakon, Masato

Published
2023
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13. The DOLFIN method: a novel laparoscopic Billroth-I gastroduodenostomy for gastric cancer with duodenal invasion

Author

Shinno, Naoki, Omori, Takeshi, Hara, Hisashi, Yamamoto, Masaaki, Fujita, Kohei, Kanemura, Takashi, Takeoka, Tomohira, Sugase, Takahito, Yasui, Masayoshi, Matsuda, Chu, Wada, Hiroshi, Nishimura, Junichi, Haraguchi, Naotsugu, Akita, Hirofumi, Hasegawa, Shinichiro, Nakai, Nozomu, Asukai, Kei, Mukai, Yousuke, Miyata, Hiroshi, Ohue, Masayuki, and Sakon, Masato

Published
2022
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14. Laparoscopic Proximal Gastrectomy with Novel Valvuloplastic Esophagogastrostomy vs. Laparoscopic Total Gastrectomy for Stage I Gastric Cancer: a Propensity Score Matching Analysis

Author

Yamamoto, Masaaki, Omori, Takeshi, Shinno, Naoki, Hara, Hisashi, Fujii, Yoshiaki, Mukai, Yosuke, Sugase, Takahito, Takeoka, Tomohira, Asukai, Kei, Kanemura, Takashi, Hasegawa, Shinichiro, Akita, Hirofumi, Haraguchi, Naotsugu, Nishimura, Junichi, Wada, Hiroshi, Matsuda, Chu, Yasui, Masayoshi, Miyata, Hiroshi, and Ohue, Masayuki

Published
2022
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15. The clinical impact of modified transpancreatic mattress sutures with polyglactin 910 woven mesh on postoperative pancreatic fistula in distal pancreatectomy

Author

Imamura, Hiroki, Takahashi, Hidenori, Akita, Hirofumi, Wada, Hiroshi, Mukai, Yosuke, Asukai, Kei, Hasegawa, Shinichiro, Fujii, Yoshiaki, Sugase, Takahito, Yamamoto, Masaaki, Takeoka, Tomohira, Shinno, Naoki, Hara, Hisashi, Kanemura, Takashi, Haraguchi, Naotsugu, Nishimura, Junichi, Matsuda, Chu, Yasui, Masayoshi, Omori, Takeshi, Miyata, Hiroshi, Ohue, Masayuki, and Sakon, Masato

Published
2022
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17. Endoscopic mucosal resection and open-lid submucosal biopsy for the diagnosis of diffuse infiltrative gastric cancer: a retrospective observational study.

Author

Kawakami, Yushi, Shichijo, Satoki, Uedo, Noriya, Weiquan Li, James, Nobre, Renata, Tani, Yasuhiro, Kitagawa, Daiki, Ninomiya, Takehiro, Ueda, Tomoya, Asada, Yuya, Okubo, Yuki, Kizawa, Atsuko, Yoshii, Shunsuke, Kanesaka, Takashi, Higashino, Koji, Michida, Tomoki, Ishihara, Ryu, Shinno, Naoki, Hara, Hisashi, and Omori, Takeshi

Abstract

Background and study aims: Diffuse infiltrative gastric cancer can be difficult to diagnose owing to a lack of endoscopic features in the superficial mucosa. Moreover, a forceps biopsy may not reveal a pathological diagnosis. We aimed to evaluate the diagnostic yield and safety of endoscopic mucosal resection (EMR) and 'open-lid submucosal biopsy', a technique wherein EMR followed by biopsy of the ulcer floor is performed for a pathological diagnosis. Patients and methods: This retrospective observational study involved patients with suspected diffuse invasive gastric cancer on endoscopy and cross-sectional imaging in whom endoscopic forceps biopsy did not lead to a pathological diagnosis. Patients who underwent EMR and open-lid submucosal biopsy were included. The primary outcome was the total diagnostic yield. The secondary outcomes were the diagnostic yields of EMR and open-lid submucosal biopsy and incidence of complications. Results: Between June 2011 and February 2022, EMR and open-lid submucosal biopsy for diagnostic purposes were performed on seven patients without complications. EMR was diagnostic in four (57%) cases of diffuse infiltrative gastric cancer. Open-lid submucosal biopsy was diagnostic in five (71%) cases. As the primary endpoint, the combination of EMR and open-lid submucosal biopsy led to a pathological diagnosis in six cases (86%). Secondary analysis revealed gastric adenocarcinoma in 9 of 22 (41%) EMR specimens, while open-lid submucosal biopsies were positive for adenocarcinoma in 14 of 60 specimens (23%). Conclusions: The combination of EMR and open-lid submucosal biopsy was safe and showed good accuracy for the diagnosis of diffuse infiltrative gastric cancer. [ABSTRACT FROM AUTHOR]

Published
2025
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18. Prognostic Value of a Novel Index Combining the Prognostic Nutritional Index and D-Dimer Levels for Gastric Cancer after Gastrectomy.

Author

Yamamoto, Masaaki, Omori, Takeshi, Shinno, Naoki, Hara, Hisashi, Mukai, Yosuke, Sugase, Takahito, Takeoka, Tomohira, Kanemura, Takashi, Mikamori, Manabu, Hasegawa, Shinichiro, Akita, Hirofumi, Haraguchi, Naotsugu, Nishimura, Junichi, Wada, Hiroshi, Matsuda, Chu, Yasui, Masayoshi, Miyata, Hiroshi, and Ohue, Masayuki

Abstract

Introduction: The prognostic nutritional index (PNI) and D-dimer level are two useful measures for gastric cancer prognosis. As they each comprise different factors, it is possible to employ a more useful combined indicator. This study therefore aimed to establish a PNI-D score – which combines the PNI and D-dimer level – and validate its usefulness as a prognostic marker. Methods: We collected data from 1,218 patients with gastric cancer who had undergone radical gastrectomy (R0) between January 2004 and December 2015. Patients were divided into three PNI-D score groups based on the following criteria: score 2, low-PNI (≤46) and high D-dimer levels (>1.0 µg/mL); score 1, either low-PNI or high D-dimer levels; and score 0, no abnormality. We defined the PNI-D score as low (score 0 or 1) and high (score 2), respectively. Results: The PNI-D score was significantly associated with overall, recurrence-free, and disease-specific survival (all log-rank p < 0.0001). The 5-year overall survival rates of patients with PNI-D scores of low and high were 88.1% and 64.7%, respectively; their 5-year recurrence-free survival rates were 86.7% and 61.3%, respectively; and their 5-year disease-specific survival rates were 99.3% and 76.5%, respectively. Cox multivariate analysis revealed that a high-PNI-D score was an independent, statistically significant prognostic factor for poor overall (p = 0.01) survival in patients with gastric cancer. Conclusions: The PNI-D is an independent prognostic factor for patients with gastric cancer. [ABSTRACT FROM AUTHOR]

Published
2025
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19. Minimally invasive surgery versus open gastrectomy for older patients with gastric cancer: A propensity score‐matching analysis.

Author

Yamamoto, Masaaki, Omori, Takeshi, Masuike, Yasunori, Shinno, Naoki, Hara, Hisashi, Sugase, Takahito, Kanemura, Takashi, Takeno, Atsushi, Hirao, Motohiro, and Miyata, Hiroshi

Subjects
MINIMALLY invasive procedures, SURGERY, OLDER patients, STOMACH cancer, CANCER patients
Abstract

Aim: To compare minimally invasive and open surgery for older patients with gastric cancer. Methods: This study included 464 consecutive patients with gastric cancer aged ≥75 years who underwent open or laparoscopic gastrectomy at our institution from January 2004 to December 2018. We performed propensity score‐matching and compared short‐ and long‐term outcomes between the two groups. Results: After matching, 332 patients were included in the study (166 in each group). The laparoscopy group had a longer operative time, lesser blood loss, and shorter hospital stays than the open surgery group (all p < 0.020). The laparoscopy group had a lower complication rate than the open surgery group (p = 0.002). No significant differences were noted in the 3‐y overall, recurrence‐free, and disease‐free survival between the groups (all p > 0.200). Conclusion: Minimally invasive surgery for older patients with gastric cancer may be more beneficial than open gastrectomy in terms of blood loss and hospital stay. [ABSTRACT FROM AUTHOR]

Published
2025
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21. Clinical importance of carcinoembryonic antigen messenger RNA level in peritoneal lavage fluids measured by transcription-reverse transcription concerted reaction for advanced gastric cancer in laparoscopic surgery

Author

Fujita, Kohei, Omori, Takeshi, Hara, Hisashi, Shinno, Naoki, Yamamoto, Masaaki, Aoyama, Yoshimasa, Sugimura, Keijiro, Kanemura, Takashi, Takeoka, Tomohira, Yasui, Masayoshi, Matsuda, Chu, Takahashi, Hidenori, Wada, Hiroshi, Nishimura, Junichi, Haraguchi, Naotsugu, Hasegawa, Shinichiro, Nakai, Nozomu, Asukai, Kei, Mukai, Yosuke, Miyata, Hiroshi, Ohue, Masayuki, and Sakon, Masato

Published
2022
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22. Postoperative aggressive diuresis prevents postoperative tissue edema and complications in patients undergoing distal pancreatectomy

Author

Imamura, Hiroki, Takahashi, Hidenori, Wada, Hiroshi, Mukai, Yosuke, Asukai, Kei, Hasegawa, Shinichiro, Yamamoto, Masaaki, Takeoka, Tomohira, Shinno, Naoki, Hara, Hisashi, Kanemura, Takashi, Nakai, Nozomu, Haraguchi, Naotsugu, Sugimura, Keijiro, Nishimura, Junichi, Matsuda, Chu, Yasui, Masayoshi, Omori, Takeshi, Miyata, Hiroshi, Ohue, Masayuki, and Sakon, Masato

Published
2022
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23. Robotic total gastrectomy with thrombectomy and portal vein reconstruction for gastric cancer and portal vein tumor thrombus

Author

Yamamoto, Masaaki, Omori, Takeshi, Shinno, Naoki, Hara, Hisashi, Mukai, Yosuke, Sugase, Takahito, Takeoka, Tomohira, Asukai, Kei, Kanemura, Takashi, Nakai, Nozomu, Hasegawa, Shinichiro, Sugimura, Keijiro, Akita, Hirofumi, Haraguchi, Naotsugu, Nishimura, Junichi, Wada, Hiroshi, Takahashi, Hidenori, Matsuda, Chu, Yasui, Masayoshi, Miyata, Hiroshi, and Ohue, Masayuki

Published
2022
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27. Predictive value of preoperative echocardiographic assessment for postoperative atrial fibrillation after esophagectomy for esophageal cancer

Author

Nagatsuka, Yuta, Sugimura, Keijiro, Miyata, Hiroshi, Shinnno, Naoki, Asukai, Kei, Hara, Hisashi, Hasegawa, Shinichiro, Yamada, Daisaku, Yamamoto, Kazuyoshi, Haraguchi, Naotsugu, Nishimura, Junichi, Motoori, Masaaki, Wada, Hiroshi, Takahashi, Hidenori, Yasui, Masayoshi, Omori, Takeshi, Ohue, Masayuki, and Yano, Masahiko

Published
2021
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28. Prognostic impact of nodal status and lymphovascular invasion in patients undergoing neoadjuvant chemotherapy for esophageal squamous cell carcinoma.

Author

Miyata, Hiroshi, Sugimura, Keijirou, Kanemura, Takashi, Takeoka, Tomohira, Sugase, Takahito, Yasui, Masayoshi, Nishimura, Junichi, Wada, Hiroshi, Akita, Hiroshi, Yamamoto, Masaaki, Hara, Hisashi, Shinno, Naoki, Omori, Takeshi, and Yano, Masahiko

Subjects
NEOADJUVANT chemotherapy, CANCER prognosis, PROGNOSIS, OVERALL survival, SQUAMOUS cell carcinoma, ESOPHAGEAL cancer
Abstract

Nodal status is well known to be the most important prognostic factor for esophageal cancer patients, even if they are treated with neoadjuvant therapy. To establish an optimal postoperative adjuvant strategy for patients, we aimed to more accurately predict the prognosis of patients and systemic recurrence by using clinicopathological factors, including nodal status, in patients with esophageal cancer who received neoadjuvant chemotherapy. The clinicopathological factors associated with survival and systemic recurrence were investigated in 488 patients with esophageal squamous cell carcinoma who received neoadjuvant chemotherapy. Overall survival differed according to tumor depth, nodal status, tumor regression, and lymphovascular (LV) invasion. In the multivariate analysis, nodal status and LV invasion were identified as independent prognostic factors (P  < 0.0001, P  = 0.0008). Nodal status was also identified as an independent factor associated with systemic recurrence, although LV invasion was a borderline factor (P  = 0.066). In each pN stage, patients with LV invasion showed significantly worse overall survival than those without LV invasion (pN0: P  = 0.036, pN1: P  = 0.0044, pN2: P  = 0.0194, pN3: P  = 0.0054). Patients with LV invasion were also more likely to have systemic, and any recurrence than those without LV invasion in each pN stage. Pathological nodal status and LV invasion were the most important predictors of survival and systemic recurrence in patients with esophageal cancer who underwent neoadjuvant chemotherapy followed by surgery. This finding could provide useful information about selecting candidates for adjuvant therapy among these patients. Our analysis showed that LV invasion was an independent prognostic factor in patients with esophageal cancer who underwent neoadjuvant chemotherapy and that combining LV invasion with pathological nodal status makes it possible to stratify the prognosis in those patients. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Clinical implications of the serum CA19-9 level in “biological borderline resectability” and “biological downstaging” in the setting of preoperative chemoradiation therapy for pancreatic cancer

Author

Takahashi, Hidenori, Yamada, Daisaku, Asukai, Kei, Wada, Hiroshi, Hasegawa, Shinichiro, Hara, Hisashi, Shinno, Naoki, Ushigome, Hajime, Haraguchi, Naotsugu, Sugimura, Keijiro, Yamamoto, Kazuyoshi, Nishimura, Junichi, Yasui, Masayoshi, Omori, Takeshi, Miyata, Hiroshi, Ohue, Masayuki, Yano, Masahiko, Sakon, Masato, and Ishikawa, Osamu

Published
2020
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30. Decreased CT-number in the pancreatic parenchyma is a reliable imaging biomarker of the presence of malignancies in patients with high-risk intraductal papillary mucinous neoplasm

Author

Abe, Tomoki, Yamada, Daisaku, Asukai, Kei, Hasegawa, Shinichiro, Tomokuni, Akira, Wada, Hiroshi, Fujii, Wataru, Ikezawa, Kenji, Fukutake, Nobuyasu, Ohkawa, Kazuyoshi, Shinno, Naoki, Hara, Hisashi, Yanagimoto, Yoshitomo, Takahashi, Yusuke, Sugimura, Keijiro, Yamamoto, Kazuyoshi, Ushigome, Hajime, Haraguchi, Naotsugu, Nishimura, Junichi, Yasui, Masayoshi, Omori, Takeshi, Miyata, Hiroshi, Ohue, Masayuki, Yano, Masahiko, Sakon, Masato, and Takahashi, Hidenori

Published
2020
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32. Anti-glypican-1 antibody–drug conjugate is a potential therapy against pancreatic cancer

Author

Nishigaki, Takahiko, Takahashi, Tsuyoshi, Serada, Satoshi, Fujimoto, Minoru, Ohkawara, Tomoharu, Hara, Hisashi, Sugase, Takahito, Otsuru, Toru, Saito, Yurina, Tsujii, Shigehiro, Nomura, Taisei, Tanaka, Koji, Miyazaki, Yasuhiro, Makino, Tomoki, Kurokawa, Yukinori, Nakajima, Kiyokazu, Eguchi, Hidetoshi, Yamasaki, Makoto, Mori, Masaki, Doki, Yuichiro, and Naka, Tetsuji

Published
2020
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33. Laparoscopic-assisted disinvagination and polypectomy for multiple intussusceptions induced by small intestinal polyps in patients with Peutz-Jeghers syndrome: a case report

Author

Yamamoto, Masaaki, Iwamoto, Kazuya, Suzuki, Rei, Mukai, Yosuke, Takeoka, Tomohira, Asukai, Kei, Shinno, Naoki, Hara, Hisashi, Kanemura, Takashi, Nakai, Nozomu, Hasegawa, Shinichiro, Sugimura, Keijiro, Haraguchi, Naotsugu, Nishimura, Junichi, Wada, Hiroshi, Takahashi, Hidenori, Matsuda, Chu, Yasui, Masayoshi, Omori, Takeshi, Miyata, Hiroshi, Ohue, Masayuki, and Murata, Masaru

Published
2021
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34. A phase II study of the safety of olanzapine for oxaliplatin based chemotherapy in coloraectal patients

Author

Nishimura, Junichi, Hasegawa, Akiko, Kudo, Toshihiro, Otsuka, Tomoyuki, Yasui, Masayoshi, Matsuda, Chu, Haraguchi, Naotsugu, Ushigome, Hajime, Nakai, Nozomu, Abe, Tomoki, Hara, Hisashi, Shinno, Naoki, Asukai, Kei, Hasegawa, Shinichiro, Yamada, Daisaku, Sugimura, Keijiro, Yamamoto, Kazuyoshi, Wada, Hiroshi, Takahashi, Hidenori, Omori, Takeshi, Miyata, Hiroshi, and Ohue, Masayuki

Published
2021
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35. Clinical Impact of Early Tumour Shrinkage in Metastatic or Unresectable Oesophageal Cancer Treated with Pembrolizumab plus Chemotherapy.

Author

Sugase, Takahito, Kanemura, Takashi, Takeoka, Tomohira, Matsuura, Norihiro, Masuike, Yasunori, Shinno, Naoki, Hara, Hisashi, Omori, Takeshi, Kitakaze, Masatoshi, Kubo, Masahiko, Mukai, Yosuke, Sueda, Toshinori, Hasegawa, Shinichiro, Akita, Hirofumi, Nishimura, Junichi, Wada, Hiroshi, Yasui, Masayoshi, and Miyata, Hiroshi

Subjects
THERAPEUTIC use of monoclonal antibodies, PREDICTIVE tests, IMMUNOTHERAPY, ESOPHAGEAL tumors, TREATMENT effectiveness, DESCRIPTIVE statistics, MULTIVARIATE analysis, METASTASIS, CANCER chemotherapy, LOG-rank test, PROGRAMMED cell death 1 receptors, COMBINED modality therapy, PROGRESSION-free survival, OVERALL survival
Abstract

Introduction: Metastatic or unresectable locally advanced oesophageal cancer remains a disease with high mortality. More recently, pembrolizumab plus chemotherapy has been indicated as the first-line treatment for those patients, but the predictive factors for treatment efficacy remain controversial. This study investigated the clinical utility of early tumour shrinkage (ETS) and depth of response (DpR) in metastatic or unresectable oesophageal cancer treated with pembrolizumab plus CF therapy. Methods: ETS and DpR, defined as the percent decreases at the second evaluation and the percentage of the maximal tumour shrinkage during treatment, were measured in 53 eligible patients. The ETS and DpR cut-off values were 20% and 30%, respectively, based on survival outcomes. Results: Twenty-seven patients (51%) were treatment naïve, while 26 (49%) had received any treatment before initiating pembrolizumab plus CF therapy. The median progression-free survival (PFS) and overall survival for ETS ≥20% and <20% were 12.7 and 5.5 months and 14.4 and 8.2 months and 12.7 and 4.9 months and 14.4 and 8.0 months for DpR ≥30% and <30%, respectively. ETS <20% showed early tumour growth, whereas ETS ≥20% had a good response rate with sufficient longer response duration. In addition, an ETS cut-off of 20% predicted the best overall response and was not associated with prior treatment. In multivariable analysis, ETS ≥20% and DpR ≥30% were independent factors of longer PFS. Conclusion: Our findings suggest that an ETS is a promising on-treatment marker for early prediction of further sensitivity to pembrolizumab plus CF therapy. [ABSTRACT FROM AUTHOR]

Published
2024
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36. Clinical Impact of Early Tumour Shrinkage in Metastatic or Unresectable Oesophageal Cancer Treated with Pembrolizumab plus Chemotherapy

Author

Sugase, Takahito, primary, Kanemura, Takashi, additional, Takeoka, Tomohira, additional, Matsuura, Norihiro, additional, Masuike, Yasunori, additional, Shinno, Naoki, additional, Hara, Hisashi, additional, Omori, Takeshi, additional, Kitakaze, Masatoshi, additional, Kubo, Masahiko, additional, Mukai, Yosuke, additional, Sueda, Toshinori, additional, Hasegawa, Shinichiro, additional, Akita, Hirofumi, additional, Nishimura, Junichi, additional, Wada, Hiroshi, additional, Yasui, Masayoshi, additional, and Miyata, Hiroshi, additional

Published
2023
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37. Significance of Comprehensive Analysis of Preoperative Sarcopenia Based on Muscle Mass, Muscle Strength, and Physical Function for the Prognosis of Patients with Esophageal Cancer

Author

Kanemura, Takashi, primary, Takeoka, Tomohira, additional, Sugase, Takahito, additional, Urakawa, Shinya, additional, Masuike, Yasunori, additional, Shinno, Naoki, additional, Hara, Hisashi, additional, Kitakaze, Masatoshi, additional, Kubo, Masahiko, additional, Mukai, Yousuke, additional, Sueda, Toshinori, additional, Hasegawa, Shinichiro, additional, Akita, Hirofumi, additional, Nishimura, Junichi, additional, Wada, Hiroshi, additional, Yasui, Masayoshi, additional, Omori, Takeshi, additional, and Miyata, Hiroshi, additional

Published
2023
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38. Clinicopathological Characteristics and Survival Outcomes in Patients with Advanced Esophageal Squamous Cell Carcinoma Who Were Intraoperatively Diagnosed Non-Curative

Author

Sugase, Takahito, primary, Kanemura, Takashi, additional, Takeoka, Tomohira, additional, Sugimura, Keijiro, additional, Yamamoto, Masaaki, additional, Shinno, Naoki, additional, Hara, Hisashi, additional, Omori, Takeshi, additional, Mukai, Yosuke, additional, Mikamori, Manabu, additional, Hasegawa, Shinichiro, additional, Haraguchi, Naotsugu, additional, Akita, Hirofumi, additional, Nishimura, Junichi, additional, Wada, Hiroshi, additional, Matsuda, Chu, additional, Yasui, Masayoshi, additional, and Miyata, Hiroshi, additional

Published
2023
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39. Adjuvant Chemotherapy With S-1 Plus DocetaxelVersusS-1 Plus Oxaliplatin in Stage III Gastric Cancer

Author

YAMAMOTO, MASAAKI, primary, OMORI, TAKESHI, additional, SHINNO, NAOKI, additional, HARA, HISASHI, additional, MUKAI, YOSUKE, additional, SUGASE, TAKAHITO, additional, TAKEOKA, TOMOHIRA, additional, MIKAMORI, MANABU, additional, KANEMURA, TAKASHI, additional, HASEGAWA, SHINICHIRO, additional, AKITA, HIROFUMI, additional, HARAGUCHI, NAOTSUGU, additional, NISHIMURA, JUNICHI, additional, WADA, HIROSHI, additional, MATSUDA, CHU, additional, YASUI, MASAYOSHI, additional, MIYATA, HIROSHI, additional, and OHUE, MASAYUKI, additional

Published
2023
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40. Clinicopathological Characteristics and Survival Outcomes in Patients with Advanced Esophageal Squamous Cell Carcinoma Who Were Intraoperatively Diagnosed Non-Curative.

Author

Sugase, Takahito, Kanemura, Takashi, Takeoka, Tomohira, Sugimura, Keijiro, Yamamoto, Masaaki, Shinno, Naoki, Hara, Hisashi, Omori, Takeshi, Mukai, Yosuke, Mikamori, Manabu, Hasegawa, Shinichiro, Haraguchi, Naotsugu, Akita, Hirofumi, Nishimura, Junichi, Wada, Hiroshi, Matsuda, Chu, Yasui, Masayoshi, and Miyata, Hiroshi

Subjects
SQUAMOUS cell carcinoma, CANCER invasiveness, TREATMENT effectiveness, DESCRIPTIVE statistics, CHEMORADIOTHERAPY, CHI-squared test, MANN Whitney U Test, SURGICAL complications, DIGESTIVE organ surgery, METASTASIS, KAPLAN-Meier estimator, DATA analysis software, ESOPHAGEAL cancer, OVERALL survival, PROPORTIONAL hazards models
Abstract

Introduction: Curative esophagectomy is not always possible in patients with locally advanced esophageal cancer. However, few studies have investigated patients who underwent non-curative surgery with intraoperative judgment. This study aimed to investigate patient characteristics and clinical outcomes for patients undergoing non-curative surgery and compare them between non-resectional and non-radical surgery. Methods: Among 989 consecutive patients with thoracic esophageal squamous cell carcinoma who were preoperatively expected for curative esophagectomy, 66 who were eligible for non-curative surgery were included in this study. Results: Intraoperative diagnosis of T4b accounted for 93% of the reasons for the failure of curative surgery. In those patients, esophageal cancer locally invaded into the aortobronchial constriction (70%), trachea (25%), or pulmonary vein (5%). Lymph node metastasis mainly invaded into the trachea (50%) or bronchus (28%). The overall survival of patients with non-curative surgery was 51.5%, 25.7%, and 10.4% at 6, 12, and 24 months after surgery, respectively. Although there were no differences in preoperative patient characteristics between non-resectional and non-radical surgery, distant metastasis, especially pleural dissemination, was significantly observed in T4b patients due to esophageal cancer with non-radical surgery than those with non-resectional surgery (35% vs. 15%, p = 0.002). Even in patients with non-curative surgery, R1 resection and postoperative chemoradiotherapy were identified as independent factors for survival 1 year after surgery (p = 0.047, and 0.019). Conclusions: T4b tumor located in aortobronchial constriction or trachea/bronchus makes it difficult to diagnose whether it is resectable or unresectable. Moreover, surgical procedures and perioperative treatment were deeply associated with the clinical outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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42. Clinical Impact of Enhanced Recovery After Esophagectomy in Patients With Esophageal Cancer

Author

SUGASE, TAKAHITO, primary, KANEMURA, TAKASHI, additional, TAKEOKA, TOMOHIRA, additional, URAKAWA, SHINYA, additional, SUGIMURA, KEIJIRO, additional, MASUIKE, YASUNORI, additional, SHINNO, NAOKI, additional, HARA, HISASHI, additional, OMORI, TAKESHI, additional, KITAKAZE, MASATOSHI, additional, KUBO, MASAHIKO, additional, MUKAI, YOSUKE, additional, SUEDA, TOSHINORI, additional, HASEGAWA, SHINICHIRO, additional, AKITA, HIROFUMI, additional, NISHIMURA, JUNICHI, additional, WADA, HIROSHI, additional, YASUI, MASAYOSHI, additional, and MIYATA, HIROSHI, additional

Published
2023
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43. Early detection of brain metastases and appropriate local therapy followed by systemic chemotherapy may improve the prognosis of gastric cancer

Author

Ishizuka, Yasunobu, primary, Omori, Takeshi, additional, Shinno, Naoki, additional, Yamamoto, Masaaki, additional, Hara, Hisashi, additional, Otsuka, Tomoyuki, additional, Nishio, Minako, additional, Nishida, Naohiro, additional, Fujisawa, Fumie, additional, Sugimoto, Naotoshi, additional, Yagi, Toshinari, additional, Goto, Masahiro, additional, Nishikawa, Hiroki, additional, and Kudo, Toshihiro, additional

Published
2023
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45. The utility of bile juice culture analysis for the management of postoperative infection after pancreaticoduodenectomy

Author

Asukai, Kei, primary, Akita, Hirofumi, additional, Mukai, Yosuke, additional, Mikamori, Manabu, additional, Hasegawa, Shinichiro, additional, Fujii, Yoshiaki, additional, Sugase, Takahito, additional, Yamamoto, Masaaki, additional, Takeoka, Tomohira, additional, Shinno, Naoki, additional, Hara, Hisashi, additional, Kanemura, Takashi, additional, Haraguchi, Naotsugu, additional, Nishimura, Junichi, additional, Matsuda, Chu, additional, Yasui, Masayoshi, additional, Omori, Takeshi, additional, Miyata, Hiroshi, additional, Ohue, Masayuki, additional, Sakon, Masato, additional, Wada, Hiroshi, additional, and Takahashi, Hidenori, additional

Published
2022
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48. Modified Collard technique is more effective than circular stapled for cervical esophagogastric anastomosis in prevention of anastomotic stricture: a propensity score-matched study

Author

Takeoka, Tomohira, primary, Miyata, Hiroshi, additional, Sugimura, Keijiro, additional, Kanemura, Takashi, additional, Sugase, Takahito, additional, Yamamoto, Masaaki, additional, Shinno, Naoki, additional, Hara, Hisashi, additional, Fujii, Yoshiaki, additional, Mukai, Yosuke, additional, Asukai, Kei, additional, Mikamori, Manabu, additional, Hasegawa, Shinichiro, additional, Akita, Hirofumi, additional, Haraguchi, Naotsugu, additional, Nishimura, Junichi, additional, Wada, Hiroshi, additional, Matsuda, Chu, additional, Omori, Takeshi, additional, Yasui, Masayoshi, additional, Ohue, Masayuki, additional, and Yano, Masahiko, additional

Published
2022
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50. Antemortem diagnosis of pulmonary tumor thrombotic microangiopathy associated with gastric cancer and response to immediate chemotherapy

Author

Fujita, Kohei, primary, Omori, Takeshi, additional, Hara, Hisashi, additional, Shinno, Naoki, additional, Yamamoto, Masaaki, additional, Kanemura, Takashi, additional, Takeoka, Tomohira, additional, Sugase, Takahito, additional, Miyata, Hiroshi, additional, Ohue, Masayuki, additional, and Sakon, Masato, additional

Published
2022
Full Text
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