1. Oral hairy leukoplakia is not a specific sign of HIV-infection but related to immunosuppression in general
- Author
-
Laine P, Niemelä M, Stina Syrjänen, and Happonen Rp
- Subjects
Hairy leukoplakia ,Adult ,Male ,Cancer Research ,Herpesvirus 4, Human ,Acute myeloblastic leukemia ,medicine.medical_treatment ,medicine.disease_cause ,Herpesviridae ,Pathology and Forensic Medicine ,Acquired immunodeficiency syndrome (AIDS) ,medicine ,Humans ,Immunosuppression Therapy ,Oral hairy leukoplakia ,business.industry ,Nucleic Acid Hybridization ,Immunosuppression ,medicine.disease ,Virology ,Epstein–Barr virus ,Tongue Neoplasms ,Leukemia ,Leukemia, Myeloid, Acute ,Tumor Virus Infections ,Otorhinolaryngology ,Immunology ,DNA, Viral ,Periodontics ,Oral Surgery ,Leukoplakia, Oral ,business ,DNA Probes - Abstract
Oral hairy leukoplakia (HL) has been regarded as an early sign of HIV infection, and its clinical importance related to the poor outcome of the patients has been emphasized. Initially, HL was observed exclusively among male homosexuals, but subsequently demonstrated in all risk groups of HIV infection. The patient described in this article suggests that oral HL is not specific for HIV infection per se, but may be associated with immunosuppression also due to other causes. We describe an HIV-seronegative, heterosexual man suffering from an acute myeloblastic leukemia, who developed clinically and histologically typical HL while on cytostatics. Biopsy showed areas with characteristic ballooning cells, and hyphae of yeasts were demonstrated with PAS-stain. Using the in situ hybridization technique, Epstein-Barr virus (EBV) DNA with high copy numbers was disclosed in the superficial and intermediate cells, whereas human papillomavirus (HPV) DNA (types 6, 11, 16, 18) was not present.
- Published
- 1989