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Exosomes, vesicular structures originating from cells, participate in the conveyance of proteins and nucleic acids. Presently, the centrality of epigenetic modifications in neurological disorders is widely acknowledged. Exosomes exert influence over various epigenetic phenomena, thereby modulating post-transcriptional regulatory processes contingent upon their constituent makeup. Consequently, the heightened attention directed toward exosomes as instigators of epigenetic alterations has burgeoned in recent years. Notably, exosomes serve as vehicles for delivering methyltransferases to recipient cells. More significantly, non-coding RNAs, particularly microRNAs (miRNAs), represent pivotal contents within exosomes, wielding the capacity to influence the expression of diverse factors within the cerebral milieu. The transfer of these exosomal contents amidst brain cells, encompassing neuronal cells and microglia, assumes a critical role in the genesis and progression of neurological disorders, also, this role is not limited to neurological disorders, it may deal with any human disease, such as cancer, and cardiovascular diseases. This review will concentrate on elucidating the regulation of exosome-induced epigenetic events and its subsequent ramifications for neurological diseases. A more profound comprehension of the involvement of exosome-mediated epigenetic regulation in neurological disorders contributes to a heightened awareness of the etiology and advancement of cerebral afflictions.

To address the issues of the existing dry granulation process, which mostly relies on manual adjustments based on empirical experience and lacks the analysis of theoretical data, a simplified model of tablet pressing based on a modified Drucker–Prager Cap (DPC) material constitutive model was proposed to simulate and analyze the forming process of tablets, and study the impacts of the feeding speed, roller speed, friction coefficient and roller clearance on the density distribution of the pressed tablets via ABAQUS. The results show that the roller speed significantly impacts the density of tablets, and a lower roller speed and a higher friction coefficient are beneficial to the formation of tablets. As the roller clearance decreases, the average density at the clearance increases, and the unevenness of the lateral density distribution of the tablets increases, showing a distribution trend of larger density at the center and smaller density on both sides.