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11 results on '"Haoyue Zhong"'

1. Vaginal and endometrial microbiome dysbiosis associated with adverse embryo transfer outcomes

Author

Weijue Su, Chaochao Gong, Haoyue Zhong, Huaqing Yang, Yuyan Chen, Xiaoyuan Wu, Jing Jin, Haitao Xi, and Junzhao Zhao

Subjects
Diagnostic model, Infertility, In vitro fertilization-embryo transfer, Implantation failure, Lactobacillus, Microbiome, Gynecology and obstetrics, RG1-991, Reproduction, QH471-489
Abstract

Abstract Background Assisted reproductive technology (ART) is the most effective method to treat infertility and the pathogenesis of implantation failure after in vitro fertilization-embryo transfer (IVF-ET) is a challenging filed in infertility. Microbes in the female reproductive tract are considered to be associated with gynecological and obstetric diseases. However, its effects on embryo implantation failure are unsured. Purpose This study aimed to investigate reproductive tract dysbiosis, identify different bacteria in reproductive tract as potential biomarkers of embryo implantation failure and demonstrate the pathogenesis through metabolites analysis. Methods We compared the data from 16S rRNA gene and metagenome in reproductive tracts through QIIME2 and HUMAnN2 by the times of embryo implantation failure on 239 infertile patients and 17 healthy women. Results Our study revealed a strong positive correlation between Lactobacillus abundance and embryo implantation success (IS) after IVF-ET. The microbial community composition and structure in reproductive tract showed substantially difference between the embryo implantation failure (IF) and healthy control. Moreover, we established a diagnostic model through receiver operating characteristic (ROC) with 0.913 area under curve (AUC) in IS and multiple implantation failures (MIF), verified its effectiveness with an AUC = 0.784 demonstrating microbial community alterations could efficiently discriminate MIF patients. Metagenome functional analyses of vaginal samples from another independent infertile patients after IVF-ET revealed the L-lysine synthesis pathway enriched in IF patients, along with ascended vaginal pH and decreased Lactobacillus abundance. Conclusions This study clarifies several independent relationships of bacteria in vagina and endometrial fluid on embryo implantation failure and undoubtedly broadens the understanding about female reproductive health.

Published
2024
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2. Epigenetic mechanism of RBM15 in affecting cisplatin resistance in laryngeal carcinoma cells by regulating ferroptosis

Author

Yue Liang, Haoyue Zhong, Yi Zhao, XiaoMin Tang, Chunchen Pan, Jingwu Sun, and Jiaqiang Sun

Subjects
Laryngeal carcinoma, Cisplatin resistance, RBM15, KDM5B, Ferroptosis, LncRNA FER1L4, Biology (General), QH301-705.5
Abstract

Abstract Laryngeal carcinoma (LC) is a common cancer of the respiratory tract. This study aims to investigate the role of RNA-binding motif protein 15 (RBM15) in the cisplatin (DDP) resistance of LC cells. LC-DDP-resistant cells were constructed. RBM15, lysine-specific demethylase 5B (KDM5B), lncRNA Fer-1 like family member 4 (FER1L4), lncRNA KCNQ1 overlapping transcript 1 (KCNQ1OT1), glutathione peroxidase 4 (GPX4), and Acyl-CoA synthetase long-chain family (ACSL4) was examined. Cell viability, IC50, and proliferation were assessed after RBM15 downregulation. The enrichment of insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) and N6-methyladenosine (m6A) on KDM5B was analyzed. KDM5B mRNA stability was measured after actinomycin D treatment. A tumor xenograft assay was conducted to verify the role of RBM15 in LC. Results showed that RBM15 was upregulated in LC and its knockdown decreased IC50, cell viability, proliferation, glutathione, and upregulated iron ion content, ROS, malondialdehyde, ACSL4, and ferroptosis. Mechanistically, RBM15 improved KDM5B stability in an IGF2BP3-dependent manner, resulting in FER1L4 downregulation and GPX4 upregulation. KDM5B increased KCNQ1OT1 and inhibited ACSL4. KDM5B/KCNQ1OT1 overexpression or FER1L4 knockdown promoted DDP resistance in LC by inhibiting ferroptosis. In conclusion, RBM15 promoted KDM5B expression, and KDM5B upregulation inhibited ferroptosis and promoted DDP resistance in LC by downregulating FER1L4 and upregulating GPX4, as well as by upregulating KCNQ1OT1 and inhibiting ACSL4. Silencing RBM15 inhibited tumor growth in vivo.

Published
2024
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6. Promoting the conversion of S and Li2S using a Co3O4@NC additive in all-solid-state Li–S batteries

Author

Xuefan Zheng, Yuqi Wu, Cheng Li, Jinxue Peng, Wu Yang, Zhongwei Lv, Haoyue Zhong, Zhengliang Gong, and Yong Yang

Subjects
Renewable Energy, Sustainability and the Environment, General Materials Science, General Chemistry
Abstract

Co3O4@NC as an electronically conductive additive is prepared to promote the conversion of S and Li2S in all-solid-state Li–S batteries. And an all-solid-state Li–S battery with the S–Co3O4@NC–Li7P3S11 cathode displays greatly enhanced performance.

Published
2022

10. All-solid-state batteries with slurry coated LiNi0.8Co0.1Mn0.1O2 composite cathode and Li6PS5Cl electrolyte: Effect of binder content

Author

Yang Xia, Jun Zhang, Chu Liang, Chao Zheng, Yongping Gan, Haoyue Zhong, Zhang Wenkui, Xinyong Tao, and Hui Huang

Subjects
Materials science, Renewable Energy, Sustainability and the Environment, Energy Engineering and Power Technology, 02 engineering and technology, Electrolyte, Carbon black, 010402 general chemistry, 021001 nanoscience & nanotechnology, Electrochemistry, 01 natural sciences, Cathode, 0104 chemical sciences, law.invention, chemistry.chemical_compound, Ethyl cellulose, chemistry, Chemical engineering, law, Electrode, Fast ion conductor, Ionic conductivity, Electrical and Electronic Engineering, Physical and Theoretical Chemistry, 0210 nano-technology
Abstract

The synthesis of solid electrolytes with high ionic conductivity and the design of electrode interface with preferable compatibility are critical to realize the bulk-type application of all-solid-state batteries. In order to realize the superior electrochemical performance, argyrodite Li6PS5Cl is a promising solid electrolyte in all-solid-state batteries due to high ionic conductivity and electrochemical stability. Meanwhile, the solution reprecipitation is a valid process providing intimate ionic contact between electrodes and electrolytes to mitigate the interface incompatibility. Here, a wet-slurry process by dispersing active material (LiNi0.8Co0.1Mn0.1O2), solid electrolyte (Li6PS5Cl), binder (ethyl cellulose) and conductive additives (carbon black) in anhydrous ethanol is developed to fabricate cathode. The effect of different contents of the binder in the composite cathodes on the electrochemical performance is investigated. The all-solid-state battery with a composite cathode containing 1 wt% of ethyl cellulose shows a reversible discharge capacity of 111.7 mAh g−1 at 30 °C and its capacity retention is approximately 89.7% after 100 cycles. This work demonstrates that the fast ion migration and stable interface between active particles and solid electrolyte enabled by optimum content of chemically compatible binder are critical to the electrochemical performance of all-solid-state lithium-ion batteries.

Published
2018

11. Biomass derived Ni(OH)2@porous carbon/sulfur composites synthesized by a novel sulfur impregnation strategy based on supercritical CO2 technology for advanced Li-S batteries

Author

Haoyue Zhong, Hui Huang, Xinyong Tao, Zhen Xiao, Zhang Wenkui, Chu Liang, Yang Xia, Ruyi Fang, Jun Zhang, and Yongping Gan

Subjects
Materials science, Energy Engineering and Power Technology, chemistry.chemical_element, 02 engineering and technology, Conductivity, engineering.material, 010402 general chemistry, Electrochemistry, 01 natural sciences, law.invention, Coating, law, Electrical and Electronic Engineering, Physical and Theoretical Chemistry, Solubility, Renewable Energy, Sustainability and the Environment, 021001 nanoscience & nanotechnology, Sulfur, Cathode, Supercritical fluid, 0104 chemical sciences, Chemical engineering, chemistry, engineering, Lithium, 0210 nano-technology
Abstract

The rational design and controllable synthesis of sulfur cathode with high sulfur content, superior structural stability and fascinating electrochemical properties is a vital step to realize the large-scale application of rechargeable lithium-sulfur (Li-S) batteries. However, the electric insulation of elemental sulfur and the high solubility of lithium polysulfides are two intractable obstacles to hinder the success of Li-S batteries. In order to overcome aforementioned issues, a novel strategy combined supercritical CO2 fluid technology and biotemplating method is developed to fabricate Ni(OH)2 modified porous carbon microspheres as sulfur hosts to ameliorate the electronic conductive of sulfur and enhance simultaneously the physical and chemical absorptions of polysulfides. This elaborately designed Ni(OH)2@PYC/S composite cathode exhibits high reversible discharge capacity (1335 mAh g−1 at 0.1 C), remarkable cyclic stability (602 mAh g−1 after 200 cycles at 0.2 C) and superior rate capability, which is much better than its PYC/S counterpart. These results clearly demonstrate that the advanced porous carbon with good conductivity and the polar Ni(OH)2 coating layer with strong trapping ability of polysulfides are responsible for the enhanced electrochemical performance.

Published
2018

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