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3 results on '"Haolin Xin"'

1. Attenuated glutamate induced ROS production by antioxidative compounds in neural cell lines

Author

Ning Yu, Zhongping An, Haolin Xin, Qian Yang, Xuan Zou, and Ying Cui

Subjects
chemistry.chemical_classification, Reactive oxygen species, General Chemical Engineering, Glutamate receptor, Neurotoxicity, 02 engineering and technology, General Chemistry, 010402 general chemistry, 021001 nanoscience & nanotechnology, medicine.disease, medicine.disease_cause, 01 natural sciences, 0104 chemical sciences, Cell biology, chemistry.chemical_compound, chemistry, medicine, 0210 nano-technology, Cytotoxicity, Cell damage, Intracellular, Reactive nitrogen species, Oxidative stress
Abstract

Glutamate is an excitatory neurotransmitter involved in neural function. Excess accumulation of intercellular glutamate leads to increasing concentration of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in neuronal cells. In this study, we investigated the antioxidant activity of several typical superior compounds among four neuronal cells, and determined the scavenging activity of free radicals. The in vivo assay was also carried out to compare the protective effect of glutamate-induced cell damage. Hierarchical clustering analysis was used to identify the common properties. Glutamate induced neurotoxicity and ROS production, suggesting glutamate cytotoxicity was related to oxidative stress and widely exists in different cell lines. Those screening compounds exhibited strong antioxidant ability, but low cytotoxicity to neuronal cells, acting as agents against neurodegenerative diseases. Finally, a hierarchical clustering analysis assay indicated that hyperoside and rutin hydrate are the most effective compounds for attenuating intercellular ROS levels. The results suggested the activity more or less relies on structure, rather than residues. These data generate new supporting ideas to remove intracellular ROS and the identified compounds serve as potential therapeutic agents in multiple neurological diseases.

Published
2019

2. Sex differences in outcomes after stroke among patients with low total cholesterol levels: a large hospital-based prospective study

Author

Yan Hong, Haolin Xin, Guanen Zhou, Zhongping An, Xianjia Ning, Wenjuan Zhao, and Jinghua Wang

Subjects
medicine.medical_specialty, Outcomes, 030204 cardiovascular system & hematology, Gender Studies, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Internal medicine, Diabetes mellitus, Total cholesterol, Sex differences, Medicine, cardiovascular diseases, Prospective cohort study, Stroke, Disease burden, Ischemic stroke, business.industry, Research, medicine.disease, Obesity, Metformin, Physical therapy, business, 030217 neurology & neurosurgery, medicine.drug
Abstract

Background Previous studies have shown that total cholesterol (TC) levels are associated with stroke outcomes, but sex differences in the association between TC levels, especially a low TC level, and ischemic stroke outcomes are unknown. We aimed to assess the sex differences in stroke outcomes among patients with atherothrombotic infarctions and low TC levels in China. Methods This study recruited patients with atherothrombotic infarctions from Tianjin, China, between May 2005 and September 2014. Patients with low TC levels (defined as TC

Published
2016

3. Sex differences in outcomes after stroke among patients with low total cholesterol levels: a large hospital-based prospective study.

Author

Guanen Zhou, Zhongping An, Wenjuan Zhao, Yan Hong, Haolin Xin, Xianjia Ning, and Jinghua Wang

Subjects
CHOLESTEROL in the body, STROKE patients, ASIANS, HEALTH
Abstract

Background: Previous studies have shown that total cholesterol (TC) levels are associated with stroke outcomes, but sex differences in the association between TC levels, especially a low TC level, and ischemic stroke outcomes are unknown. We aimed to assess the sex differences in stroke outcomes among patients with atherothrombotic infarctions and low TC levels in China. Methods: This study recruited patients with atherothrombotic infarctions from Tianjin, China, between May 2005 and September 2014. Patients with low TC levels (defined as TC <4.22 mmol/L) were analyzed in this study. Sex differences in stroke subtypes, severity, risk factors, and outcomes at 3 and 12 months after stroke were compared. Results: Overall, 1587 patients with low TC levels were recruited to this study from among 6407 patients with atherothrombotic infarctions listed in a stroke registry. Women were more likely than men to have posterior circulation infarcts, severe stroke, hypertension, and obesity but less likely to be current smokers or to consume alcohol. There were no sex differences in stroke outcomes. Older age and severe stroke were common risk factors for poor outcomes after stroke in this study. The presence of diabetes mellitus was an independent predictor of low mortality at 12 months after stroke, possibly because a drug commonly used to treat diabetes, metformin, enhances angiogenesis. Obesity was the determinant of the recurrence and dependency rates at 12 months after stroke. Conclusions: These findings suggest that patients (both men and women) with atherothrombotic infarction who have low TC levels would not benefit from receiving statin treatment. Therefore, it is crucial to explore the impact of statin treatment on outcomes in Asian patients, especially Chinese patients with atherothrombotic and low TC levels, in order to improve outcomes after stroke and reduce the disease burden. [ABSTRACT FROM AUTHOR]

Published
2016
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