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14. Identifying the Potential Differentially Expressed miRNAs and mRNAs in Osteonecrosis of the Femoral Head Based on Integrated Analysis

Author

Zhaochen Xu, Hao Yangquan, Hao Guo, Baogang Zhang, Gaokui Zhang, and Chao Lu

Subjects
signaling pathway, mRNAs, osteonecrosis of the femoral head, Bioinformatics, Focal adhesion, 03 medical and health sciences, Femoral head, 0302 clinical medicine, microRNA, medicine, Humans, 030212 general & internal medicine, RNA, Messenger, Original Research, Adaptor Proteins, Signal Transducing, Messenger RNA, Cell adhesion molecule, business.industry, Wnt signaling pathway, Osteonecrosis, Nuclear Proteins, Femur Head, General Medicine, body regions, MicroRNAs, Reelin Protein, medicine.anatomical_structure, Clinical Interventions in Aging, embryonic structures, miRNAs, Geriatrics and Gerontology, Signal transduction, Chemokines, business, 030217 neurology & neurosurgery, WNT3A, Signal Transduction
Abstract

Yangquan Hao, Chao Lu, Baogang Zhang, Zhaochen Xu, Hao Guo, Gaokui Zhang Department of Osteonecrosis and Joint Reconstruction, Honghui Hospital Xian Jiao Tong University Health Science Center, Xian, Shaanxi 710068, People’s Republic of ChinaCorrespondence: Yangquan HaoDepartment of Osteonecrosis and Joint Reconstruction, Honghui Hospital Xian Jiao Tong University Health Science Center, No. 555 Youyi East Road, Xian, Shaanxi 710068, People’s Republic of ChinaTel +86 13991038599Fax +86 29-87894724Email yangquan_haodoctor@163.comPurpose: Osteonecrosis of the femoral head is a common disease of the hip that leads to severe pain or joint disability. We aimed to identify potential differentially expressed miRNAs and mRNAs in osteonecrosis of the femoral head.Methods: The data of miRNA and mRNA were firstly downloaded from the database. Secondly, the regulatory network of miRNAs–mRNAs was constructed, followed by function annotation of mRNAs. Thirdly, an in vitro experiment was applied to validate the expression of miRNAs and targeted mRNAs. Finally, GSE123568 dataset was used for electronic validation and diagnostic analysis of targeted mRNAs.Results: Several regulatory interaction pairs between miRNA and mRNAs were identified, such as hsa-miR-378c-WNT3A/DACT1/CSF1, hsa-let-7a-5p-RCAN2/IL9R, hsa-miR-28-5p-RELA, hsa-miR-3200-5p-RELN, and hsa-miR-532-5p-CLDN18/CLDN10. Interestingly, CLDN10, CLDN18, CSF1, DACT1, IL9R, RCAN2, RELN, and WNT3A had the diagnostic value for osteonecrosis of the femoral head. Wnt signaling pathway (involved WNT3A), chemokine signaling pathway (involved RELA), focal adhesion and ECM-receptor interaction (involved RELN), cell adhesion molecules (CAMs) (involved CLDN18 and CLDN10), cytokine–cytokine receptor interaction, and hematopoietic cell lineage (involved CSF1 and IL9R) were identified.Conclusion: The identified differentially expressed miRNAs and mRNAs may be involved in the pathology of osteonecrosis of the femoral head.Keywords: osteonecrosis of the femoral head, miRNAs, mRNAs, signaling pathway

Published
2021

16. Identifying the Potential Differentially Expressed miRNAs and mRNAs in Osteonecrosis of the Femoral Head Based on Integrated Analysis

Author

Hao,Yangquan, Lu,Chao, Zhang,Baogang, Xu,Zhaochen, Guo,Hao, Zhang,Gaokui, Hao,Yangquan, Lu,Chao, Zhang,Baogang, Xu,Zhaochen, Guo,Hao, and Zhang,Gaokui

Abstract

Yangquan Hao, Chao Lu, Baogang Zhang, Zhaochen Xu, Hao Guo, Gaokui Zhang Department of Osteonecrosis and Joint Reconstruction, Honghui Hospital Xian Jiao Tong University Health Science Center, Xian, Shaanxi 710068, People’s Republic of ChinaCorrespondence: Yangquan HaoDepartment of Osteonecrosis and Joint Reconstruction, Honghui Hospital Xian Jiao Tong University Health Science Center, No. 555 Youyi East Road, Xian, Shaanxi 710068, People’s Republic of ChinaTel +86 13991038599Fax +86 29-87894724Email yangquan_haodoctor@163.comPurpose: Osteonecrosis of the femoral head is a common disease of the hip that leads to severe pain or joint disability. We aimed to identify potential differentially expressed miRNAs and mRNAs in osteonecrosis of the femoral head.Methods: The data of miRNA and mRNA were firstly downloaded from the database. Secondly, the regulatory network of miRNAs–mRNAs was constructed, followed by function annotation of mRNAs. Thirdly, an in vitro experiment was applied to validate the expression of miRNAs and targeted mRNAs. Finally, GSE123568 dataset was used for electronic validation and diagnostic analysis of targeted mRNAs.Results: Several regulatory interaction pairs between miRNA and mRNAs were identified, such as hsa-miR-378c-WNT3A/DACT1/CSF1, hsa-let-7a-5p-RCAN2/IL9R, hsa-miR-28-5p-RELA, hsa-miR-3200-5p-RELN, and hsa-miR-532-5p-CLDN18/CLDN10. Interestingly, CLDN10, CLDN18, CSF1, DACT1, IL9R, RCAN2, RELN, and WNT3A had the diagnostic value for osteonecrosis of the femoral head. Wnt signaling pathway (involved WNT3A), chemokine signaling pathway (involved RELA), focal adhesion and ECM-receptor interaction (involved RELN), cell adhesion molecules (CAMs) (involved CLDN18 and CLDN10), cytokine–cytokine receptor interaction, and hematopoietic cell lineage (involved CSF1 and IL9R) were identified.Conclusion: The identified differentially expressed miRNAs and mRNAs may be involved in the pathology of osteonecrosis of

Published
2021

26. Comparing robot-assisted and conventional surgery in knee replacement: A meta-analysis of surgical site wound complications and recovery outcomes.

Author

Liang H, Hao Y, and Yu W

Abstract

Objective: This meta-analysis aims to assess the impact of robotic and open-cut forms on postoperative complications in knee replacement surgeries., Method: A comprehensive and systematic search was conducted on four significant databases using keywords derived from 'robot,' 'robot-assisted knee replacement (TAKR),' 'osteoarthritis,' 'knee arthroplasty,' 'wound healing,' 'knee replacement,' and 'postoperation' from the earliest available records until March 2024. A total of 590 publications were explored, and 16 related randomized clinical trials (RCTs) were analyzed in depth to unveil the role of robots in knee replacement surgery. In this meta-review, different parameters were adopted to evaluate various aspects: operation duration was used to measure the time from the primary incision to the wound closure after the surgery; Knee Society Score (KSS) and Hip Knee Ankle Angle (HKA) were used to evaluate the recovery and imaging features of the knees., Results: Data suggests there was little difference between the two methods except that the operation duration was higher in the robot-assisted group than in the conventional ones., Conclusions: In broad terms, this meta-analysis indicates that employing robotics does not decrease specific post-surgical complications, such as wound infections and painful feelings. However, this advanced medical technology of robots' application helps reduce blood loss and drainage compared to patients with conventional surgery. Consequently, utilizing a robotic approach for knee replacement surgeries may only provide moderate promotion for wound recovery after the surgery. This insight is valuable for surgeons when choosing the most appropriate operative approach., Competing Interests: Declaration of competing interest The authors declare that there is no competing interest associated with the manuscript., (Copyright © 2024 Asian Surgical Association and Taiwan Society of Coloproctology. Published by Elsevier B.V. All rights reserved.)

Published
2024
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