1. [A study on HLA-DQB1 allele associated with genetic susceptibility to duodenal ulcer in Guangdong Hans].
- Author
-
Du YP, Ye HJ, Long X, Yu J, Fang JZ, Wang JP, Hao FW, Jiang L, and Wang YY
- Subjects
- Adolescent, Adult, Aged, Alleles, Asian People genetics, China, Duodenal Ulcer ethnology, Female, Gene Frequency, Genetic Predisposition to Disease genetics, Genotype, HLA-DQ beta-Chains, Humans, Male, Middle Aged, Polymerase Chain Reaction, Young Adult, Duodenal Ulcer genetics, HLA-DQ Antigens genetics, Membrane Glycoproteins genetics
- Abstract
Objective: To study the genetic susceptibility of HLA-DQB1 alleles to duodenal ulcer in Chinese Hans from Guangdong area around., Methods: Hundred and five patients with duodenal ulcer and hundred and five healthy controls were examined for HLA-DQB1 genotypes. HLA-DQB1 allele typing was carried out by polymerase chain reaction with sequence specific primers (PCR-SSP)., Results: The allele frequency of HLA-DQB1*0602 in patients with duodenal ulcer (64.8%) was significantly higher than that in healthy controls (14.3%)., Conclusion: These findings suggest that HLA-DQB1*0602 is a susceptible gene to duodenal ulcer in Guangdong Hans of China. And at HLA-DQB1 site, there are immunogenetic differences between duodenal ulcer patients and healthy controls.
- Published
- 2006