11 results on '"Hantler, Nancy"'
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2. CSF proteomics identifies early changes in autosomal dominant Alzheimer’s disease
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Noble, James M., Day, Gregory S., Graff-Radford, Neill R., Voglein, Jonathan, Allegri, Ricardo, Mendez, Patricio Chrem, Surace, Ezequiel, Berman, Sarah B., Ikonomovic, Snezana, Nadkarni, Neelesh, Lopera, Francisco, Ramirez, Laura, Aguillon, David, Leon, Yudy, Ramos, Claudia, Alzate, Diana, Baena, Ana, Londono, Natalia, Mathias Jucker, Sonia Moreno, Laske, Christoph, Kuder-Buletta, Elke, Graber-Sultan, Susanne, Preische, Oliver, Hofmann, Anna, Ikeuchi, Takeshi, Kasuga, Kensaku, Niimi, Yoshiki, Ishii, Kenji, Senda, Michio, Sanchez-Valle, Raquel, Rosa-Neto, Pedro, Fox, Nick, Cash, Dave, Lee, Jae-Hong, Roh, Jee Hoon, Riddle, Meghan, Menard, William, Bodge, Courtney, Surti, Mustafa, Takada, Leonel Tadao, Farlow, Martin, Chhatwal, Jasmeer P., Sanchez-Gonzalez, V.J., Orozco-Barajas, Maribel, Goate, Alison, Renton, Alan, Esposito, Bianca, Karch, Celeste M., Marsh, Jacob, Cruchaga, Carlos, Fernandez, Victoria, Gordon, Brian A., Fagan, Anne M., Jerome, Gina, Herries, Elizabeth, Llibre-Guerra, Jorge, Levey, Allan I., Johnson, Erik C.B., Seyfried, Nicholas T., Schofield, Peter R., Brooks, William, Bechara, Jacob, Bateman, Randall J., McDade, Eric, Hassenstab, Jason, Perrin, Richard J., Franklin, Erin, Benzinger, Tammie L.S., Chen, Allison, Chen, Charles, Flores, Shaney, Friedrichsen, Nelly, Hantler, Nancy, Hornbeck, Russ, Jarman, Steve, Keefe, Sarah, Koudelis, Deborah, Massoumzadeh, Parinaz, McCullough, Austin, McKay, Nicole, Nicklaus, Joyce, Pulizos, Christine, Wang, Qing, Mishall, Sheetal, Sabaredzovic, Edita, Deng, Emily, Candela, Madison, Smith, Hunter, Hobbs, Diana, Scott, Jalen, Levin, Johannes, Xiong, Chengjie, Wang, Peter, Xu, Xiong, Li, Yan, Gremminger, Emily, Ma, Yinjiao, Bui, Ryan, Lu, Ruijin, Martins, Ralph, Sosa Ortiz, Ana Luisa, Daniels, Alisha, Courtney, Laura, Mori, Hiroshi, Supnet-Bell, Charlene, Xu, Jinbin, Ringman, John, Shen, Yuanyuan, Timsina, Jigyasha, Heo, Gyujin, Beric, Aleksandra, Ali, Muhammad, Wang, Ciyang, Yang, Chengran, Wang, Yueyao, Western, Daniel, Liu, Menghan, Gorijala, Priyanka, Budde, John, Do, Anh, Liu, Haiyan, Gordon, Brian, Llibre-Guerra, Jorge J., Joseph-Mathurin, Nelly, Maschi, Dario, Wyss-Coray, Tony, Pastor, Pau, Renton, Alan E., Surace, Ezequiel I., Alvarez, Ignacio, Ringman, John M., Allegri, Ricardo Francisco, Seyfried, Nicholas, Day, Gregg S., Wu, Qisi, Fernández, M. Victoria, Tarawneh, Rawan, Morris, John C., Ibanez, Laura, and Sung, Yun Ju
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- 2024
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3. Deconstructing pathological tau by biological process in early stages of Alzheimer disease: a method for quantifying tau spatial spread in neuroimaging
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Noble, James M., Day, Gregory S., Graff-Radford, Neill R., Voglein, Jonathan, Levin, Johannes, Allegri, Ricardo F., Mendez, Patricio Chrem, Surace, Ezequiel, Berman, Sarah B., Ikonomovic, Snezana, Nadkarni, Neelesh K., Lopera, Francisco, Ramirez, Laura, Aguillon, David, Leon, Yudy, Ramos, Claudia, Alzate, Diana, Baena, Ana, Londono, Natalia, Moreno, Sonia, Jucker, Mathias, Laske, Christoph, Kuder-Buletta, Elke, Graber-Sultan, Susanne, Preische, Oliver, Hofmann, Anna, Ikeuchi, Takeshi, Kasuga, Kensaku, Niimi, Yoshiki, Ishii, Kenji, Senda, Michio, Sanchez-Valle, Raquel, Rosa-Neto, Pedro, Fox, Nick C., Cash, Dave, Lee, Jae-Hong, Roh, Jee Hoon, Salloway, Stephen, Riddle, Meghan C., Menard, William, Bodge, Courtney, Surti, Mustafa, Takada, Leonel Tadao, Farlow, Martin, Chhatwal, Jasmeer P., Sanchez-Gonzalez, V.J., Orozco-Barajas, Maribel, Goate, Alison M., Renton, Alan E., Esposito, Bianca T., Karch, Celeste M., Marsh, Jacob, Cruchaga, Carlos, Fernanadez, Victoria, Gordon, Brian A., Fagan, Anne M., Jerome, Gina, Herries, Elizabeth, Llibre-Guerra, Jorge, Levey, Allan I., Johnson, Erik C.B., Seyfried, Nicholas T., Schofield, Peter R., Brooks, William S., Bechara, Jacob A., Bateman, Randall, McDade, Eric, Hassenstab, Jason, Perrin, Richard J., Franklin, Erin E., Benzinger, Tammie, Chen, Allison, Chen, Charles, Flores, Shaney, Friedrichsen, Nelly, Gordon, Brian, Hantler, Nancy, Hornbeck, Russ, Jarman, Steve, Keefe, Sarah, Koudelis, Deborah, Massoumzadeh, Parinaz, McCullough, Austin, McKay, Nicole, Nicklaus, Joyce, Pulizos, Christine, Wang, Qing, Mishall, Sheetal, Sabaredzovic, Edita, Deng, Emily, Candela, Madison, Smith, Hunter, Hobbs, Diana, Scott, Jalen, Xiong, Chengjie, Wang, Peter, Xu, Xiong, Li, Yan, Gremminger, Emily, Ma, Yinjiao, Bui, Ryan, Lu, Ruijin, Martins, Ralph, Sosa Ortiz, Ana Luisa, Daniels, Alisha, Courtney, Laura, Mori, Hiroshi, Supnet-Bell, Charlene, Xu, Jinbin, Ringman, John, Barthelemy, Nicolas, Morris, John, Smith, Jennifer, Doering, Stephanie, Chen, Charles D., Jarman, Stephen, Jackson, Kelley, Hornbeck, Russ C., Ances, Beau M., Aschenbrenner, Andrew J., Bateman, Randall J., Morris, John C., and Benzinger, Tammie L.S.
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- 2024
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4. Deconstructing pathological tau by biological process in early stages of Alzheimer disease: a method for quantifying tau spatial spread in neuroimaging
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Doering, Stephanie, primary, McCullough, Austin, additional, Gordon, Brian A., additional, Chen, Charles D., additional, McKay, Nicole, additional, Hobbs, Diana, additional, Keefe, Sarah, additional, Flores, Shaney, additional, Scott, Jalen, additional, Smith, Hunter, additional, Jarman, Stephen, additional, Jackson, Kelley, additional, Hornbeck, Russ C., additional, Ances, Beau M., additional, Xiong, Chengjie, additional, Aschenbrenner, Andrew J., additional, Hassenstab, Jason, additional, Cruchaga, Carlos, additional, Daniels, Alisha, additional, Bateman, Randall J., additional, Noble, James M., additional, Day, Gregory S., additional, Graff-Radford, Neill R., additional, Voglein, Jonathan, additional, Levin, Johannes, additional, Allegri, Ricardo F., additional, Mendez, Patricio Chrem, additional, Surace, Ezequiel, additional, Berman, Sarah B., additional, Ikonomovic, Snezana, additional, Nadkarni, Neelesh K., additional, Lopera, Francisco, additional, Ramirez, Laura, additional, Aguillon, David, additional, Leon, Yudy, additional, Ramos, Claudia, additional, Alzate, Diana, additional, Baena, Ana, additional, Londono, Natalia, additional, Moreno, Sonia, additional, Jucker, Mathias, additional, Laske, Christoph, additional, Kuder-Buletta, Elke, additional, Graber-Sultan, Susanne, additional, Preische, Oliver, additional, Hofmann, Anna, additional, Ikeuchi, Takeshi, additional, Kasuga, Kensaku, additional, Niimi, Yoshiki, additional, Ishii, Kenji, additional, Senda, Michio, additional, Sanchez-Valle, Raquel, additional, Rosa-Neto, Pedro, additional, Fox, Nick C., additional, Cash, Dave, additional, Lee, Jae-Hong, additional, Roh, Jee Hoon, additional, Salloway, Stephen, additional, Riddle, Meghan C., additional, Menard, William, additional, Bodge, Courtney, additional, Surti, Mustafa, additional, Takada, Leonel Tadao, additional, Farlow, Martin, additional, Chhatwal, Jasmeer P., additional, Sanchez-Gonzalez, V.J., additional, Orozco-Barajas, Maribel, additional, Goate, Alison M., additional, Renton, Alan E., additional, Esposito, Bianca T., additional, Karch, Celeste M., additional, Marsh, Jacob, additional, Fernanadez, Victoria, additional, Fagan, Anne M., additional, Jerome, Gina, additional, Herries, Elizabeth, additional, Llibre-Guerra, Jorge, additional, Levey, Allan I., additional, Johnson, Erik C.B., additional, Seyfried, Nicholas T., additional, Schofield, Peter R., additional, Brooks, William S., additional, Bechara, Jacob A., additional, Bateman, Randall, additional, McDade, Eric, additional, Perrin, Richard J., additional, Franklin, Erin E., additional, Benzinger, Tammie, additional, Chen, Allison, additional, Chen, Charles, additional, Friedrichsen, Nelly, additional, Gordon, Brian, additional, Hantler, Nancy, additional, Hornbeck, Russ, additional, Jarman, Steve, additional, Koudelis, Deborah, additional, Massoumzadeh, Parinaz, additional, Nicklaus, Joyce, additional, Pulizos, Christine, additional, Wang, Qing, additional, Mishall, Sheetal, additional, Sabaredzovic, Edita, additional, Deng, Emily, additional, Candela, Madison, additional, Wang, Peter, additional, Xu, Xiong, additional, Li, Yan, additional, Gremminger, Emily, additional, Ma, Yinjiao, additional, Bui, Ryan, additional, Lu, Ruijin, additional, Martins, Ralph, additional, Sosa Ortiz, Ana Luisa, additional, Courtney, Laura, additional, Mori, Hiroshi, additional, Supnet-Bell, Charlene, additional, Xu, Jinbin, additional, Ringman, John, additional, Barthelemy, Nicolas, additional, Morris, John, additional, Smith, Jennifer, additional, Morris, John C., additional, and Benzinger, Tammie L.S., additional
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- 2024
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5. Alzheimer Disease Pathology and Neurodegeneration in Midlife Obesity: A Pilot Study.
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Dolatshahi, Mahsa, Commean, Paul K., Rahmani, Farzaneh, Jingxia Liu, Lloyd, LaKisha, Nguyen, Caitlyn, Hantler, Nancy, Ly, Maria, Yu, Gary, Ippolito, Joseph E., Sirlin, Claude, Morris, John C., Benzinger, Tammie L. S., and Raji, Cyrus A.
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ALZHEIMER'S disease risk factors ,NEURODEGENERATION ,INSULIN resistance - Abstract
Obesity and excess adiposity at midlife are risk factors for Alzheimer disease (AD). Visceral fat is known to be associated with insulin resistance and a pro-inflammatory state, the two mechanisms involved in AD pathology. We assessed the association of obesity, MRI-determined abdominal adipose tissue volumes, and insulin resistance with PET-determined amyloid and tau uptake in default mode network areas, and MRIdetermined brain volume and cortical thickness in AD cortical signature in the cognitively normal midlife population. Thirty-two middle-aged (age: 51.27±6.12 years, 15 males, body mass index (BMI): 32.28±6.39 kg/m2) cognitively normal participants, underwent bloodwork, brain and abdominal MRI, and amyloid and tau PET scan. Visceral and subcutaneous adipose tissue (VAT, SAT) were semi-automatically segmented using VOXel Analysis Suite (Voxa). FreeSurfer was used to automatically segment brain regions using a probabilistic atlas. PET scans were acquired using [11C]PiB and AV-1451 tracers and were analyzed using PET unified pipeline. The association of brain volumes, cortical thicknesses, and PiB and AV-1451 standardized uptake value ratios (SUVRs) with BMI, VAT/SAT ratio, and insulin resistance were assessed using Spearman’s partial correlation. VAT/SAT ratio was associated significantly with PiB SUVRs in the right precuneus cortex (p=0.034) overall, controlling for sex. This association was significant only in males (p=0.044), not females (p=0.166). Higher VAT/SAT ratio and PiB SUVRs in the right precuneus cortex were associated with lower cortical thickness in AD-signature areas predominantly including bilateral temporal cortices, parahippocampal, medial orbitofrontal, and cingulate cortices, with age and sex as covariates. Also, higher BMI and insulin resistance were associated with lower cortical thickness in bilateral temporal poles. In midlife cognitively normal adults, we demonstrated higher amyloid pathology in the right precuneus cortex in individuals with a higher VAT/SAT ratio, a marker of visceral obesity, along with a lower cortical thickness in AD-signature areas associated with higher visceral obesity, insulin resistance, and amyloid pathology. [ABSTRACT FROM AUTHOR]
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- 2024
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6. Hemodynamic Features of Symptomatic Vertebrobasilar Disease
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Amin-Hanjani, Sepideh, Du, Xinjian, Rose-Finnell, Linda, Pandey, Dilip K, Richardson, DeJuran, Thulborn, Keith R, Elkind, Mitchell SV, Zipfel, Gregory J, Liebeskind, David S, Silver, Frank L, Kasner, Scott E, Aletich, Victor A, Caplan, Louis R, Derdeyn, Colin P, Gorelick, Philip B, Charbel, Fady T, Xie, Hui, Flannery, Michael P, Ganin, Hagai, Ruland, Sean, Grysiewicz, Rebecca, Khaja, Aslam, Pedelty, Laura, Testai, Fernando, Ong, Archie, Epstein, Noam, Muqtadar, Hurmina, Watson, Karriem, Mlinarevich, Nada, Hillmann, Maureen, Hirsch, Joy, Dashnaw, Stephen, Meyers, Philip M, Willey, Josh Z, McNeill-Simaan, Edwina, Perez, Veronica, Canaan, Alberto, Paulino-Hernandez, Wayna, Vo, Katie, Foster, Glenn, Ford, Andria, Nassief, Abdullah, Bradley, Abbie, Serna-Northway, Jannie, Kraus, Kristi, Shiwani, Lina, Hantler, Nancy, Alger, Jeffrey, Godinez, Sergio, Saver, Jeffrey L, Ali, Latisha, Kim, Doojin, Tenser, Matthew, Froehler, Michael, Raychev, Radoslav, Song, Sarah, Ovbiagele, Bruce, Abcede, Hermelinda, Adamczyk, Peter, Rao, Neal, Yallapragada, Anil, Modir, Royya, Hinman, Jason, Tansy, Aaron, Calderon-Arnulphi, Mateo, Sheth, Sunil, Noorian, Alireza, Ng, Kwan, Liang, Conrad, Gadhia, Jignesh, Smith, Hannah, Avila, Gilda, Avelar, Johanna, Mikulis, David, Fierstra, Jorn, Hlasny, Eugen, Casaubon, Leanne K, Vergouwen, Mervyn, del Campo, JC Martin, Jaigobin, Cheryl S, Astorga, Cherissa, Kalman, Libby, Kramer, Jeffrey, Vaughan, Susan, Owens, Laura, Kissela, Brett, Turan, Tanya N, Jacobs, Tom P, and Janis, Scott
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Cardiovascular ,Neurosciences ,Stroke ,Clinical Research ,Adult ,Aged ,Aged ,80 and over ,Blood Flow Velocity ,Cerebrovascular Circulation ,Cohort Studies ,Female ,Hemodynamics ,Humans ,Male ,Middle Aged ,Prospective Studies ,Risk Factors ,Vertebrobasilar Insufficiency ,magnetic resonance angiography ,magnetic resonance imaging ,regional blood flow ,stroke ,vertebrobasilar ischemia ,VERiTAS Study Group ,Cardiorespiratory Medicine and Haematology ,Clinical Sciences ,Neurology & Neurosurgery - Abstract
Background and purposeAtherosclerotic vertebrobasilar disease is an important cause of posterior circulation stroke. To examine the role of hemodynamic compromise, a prospective multicenter study, Vertebrobasilar Flow Evaluation and Risk of Transient Ischemic Attack and Stroke (VERiTAS), was conducted. Here, we report clinical features and vessel flow measurements from the study cohort.MethodsPatients with recent vertebrobasilar transient ischemic attack or stroke and ≥50% atherosclerotic stenosis or occlusion in vertebral or basilar arteries (BA) were enrolled. Large-vessel flow in the vertebrobasilar territory was assessed using quantitative MRA.ResultsThe cohort (n=72; 44% women) had a mean age of 65.6 years; 72% presented with ischemic stroke. Hypertension (93%) and hyperlipidemia (81%) were the most prevalent vascular risk factors. BA flows correlated negatively with percentage stenosis in the affected vessel and positively to the minimal diameter at the stenosis site (P
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- 2015
7. Baseline Hemodynamic Impairment and Future Stroke Risk in Adult Idiopathic Moyamoya Phenomenon: Results of a Prospective Natural History Study
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Derdeyn, Colin P., Zipfel, Gregory J., Zazulia, Allyson R., Davis, Patricia H., Prabhakaran, Shyam, Ivan, Cristina S., Aiyagari, Venkatesh, Sagar, James R., Hantler, Nancy, Shinawi, Lina, Lee, John J., Jafri, Hussain, Grubb, Robert L., Jr, Miller, J. Philip, and Dacey, Ralph G., Jr
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- 2017
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8. Sex-Specific Patterns of Body Mass Index Relationship with White Matter Connectivity
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Rahmani, Farzaneh, primary, Wang, Qing, additional, McKay, Nicole S., additional, Keefe, Sarah, additional, Hantler, Nancy, additional, Hornbeck, Russ, additional, Wang, Yong, additional, Hassenstab, Jason, additional, Schindler, Suzanne, additional, Xiong, Chengjie, additional, Morris, John C., additional, Benzinger, Tammie L.S., additional, and Raji, Cyrus A., additional
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- 2022
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9. Optimized Hemodynamic Assessment to Predict Stroke Risk in Vertebrobasilar Disease: Analysis From the VERiTAS Study
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See, Alfred P., primary, Pandey, Dilip K., additional, Du, Xinjian, additional, Rose‐Finnell, Linda, additional, Charbel, Fady T., additional, Derdeyn, Colin P., additional, Amin‐Hanjani, Sepideh, additional, Richardson, DeJuran, additional, Xie, Hui, additional, Thulborn, Keith, additional, Flanner, Michael P., additional, Ganin, Hagai, additional, Ruland, Sean, additional, Grysiewicz, Rebecca, additional, Khaja, Aslam, additional, Pedelty, Laura, additional, Testai, Fernando, additional, Ong, Archie, additional, Epstein, Noam, additional, Muqtadar, Hurmina, additional, Watson, Karriem, additional, Mlinarevich, Nada, additional, Hillmann, Maureen, additional, Elkind, Mitchell S. V., additional, Hirsch, Joy, additional, Dashnaw, Stephen, additional, Meyers, Philip M., additional, Willey, Josh Z., additional, McNeill‐Simaan, Edwina, additional, Perez, Veronica, additional, Canaan, Alberto, additional, Paulino‐Hernandez, Wayna, additional, Zipfel, Gregory J., additional, Vo, Katie, additional, Foster, Glenn, additional, Ford, Andria, additional, Nassief, Abdullah, additional, Bradley, Abbie, additional, Serna‐Northway, Jannie, additional, Kraus, Kristi, additional, Shiwani, Lina, additional, Hantler, Nancy, additional, Liebeskind, David S., additional, Alger, Jeffrey, additional, Godinez, Sergio, additional, Saver, Jeffrey L., additional, Ali, Latisha, additional, Kim, Doojin, additional, Tenser, Matthew, additional, Froehler, Michael, additional, Raychev, Radoslav, additional, Song, Sarah, additional, Ovbiagele, Bruce, additional, Abcede, Hermelinda, additional, Adamczyk, Peter, additional, Rao, Neal, additional, Yallapragada, Anil, additional, Modir, Royya, additional, Hinman, Jason, additional, Tansy, Aaron, additional, Calderon‐Arnulphi, Mateo, additional, Sheth, Sunil, additional, Noorian, Alireza, additional, Ng, Kwan, additional, Liang, Conrad, additional, Gadhia, Jignesh, additional, Smith, Hannah, additional, Avila, Gilda, additional, Avelar, Johanna, additional, Silver, Frank L., additional, Mikulis, David, additional, Fierstra, Jorn, additional, Hlasny, Eugen, additional, Casaubon, Leanne K., additional, Vergouwen, Mervyn, additional, Martin del Campo, J. C., additional, Jaigobin, Cheryl S., additional, Astorga, Cherissa, additional, Kalman, Libby, additional, Kramer, Jeffrey, additional, Vaughan, Susan, additional, Owens, Laura, additional, Thulborn, Keith R., additional, Caplan, Louis R., additional, Gorelick, Philip B., additional, Kasner, Scott E., additional, Kissela, Brett, additional, Turan, Tanya N., additional, Aletich, Victor, additional, Jacobs, Tom P., additional, and Janis, Scott, additional
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- 2020
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10. Abstract 164: The Impact Of Hemodynamic Factors On Stroke Risk In Moyamoya Phenomenon: A Prospective Natural History Study
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Derdeyn, Colin, primary, Sagar, James, additional, Lee, John, additional, Aiyagari, Venkatesh, additional, Davis, Patricia, additional, Ivan, Cristina, additional, Prabhakaran, Shyam, additional, Shinawi, Lina, additional, Hantler, Nancy, additional, Zazulia, Allyson, additional, Grubb, Robert, additional, and Zipfel, Greg, additional
- Published
- 2012
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11. Abstract 164.
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Derdeyn, Colin, Sagar, James, Lee, John, Aiyagari, Venkatesh, Davis, Patricia, Ivan, Cristina, Prabhakaran, Shyam, Shinawi, Lina, Hantler, Nancy, Zazulia, Allyson, Grubb Jr, Robert, and Zipfel, Greg
- Published
- 2012
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