Search

Your search keyword '"Hansen, Kristian"' showing total 673 results
Start Over Author "Hansen, Kristian"
673 results on '"Hansen, Kristian"'

1. Productivity and quality-adjusted life years: QALYs, PALYs and beyond

Author

Hansen, Kristian S., Moreno-Ternero, Juan D., and Østerdal, Lars P.

Subjects
Economics - Theoretical Economics
Abstract

We develop a unified framework for the measurement and valuation of health and productivity. Within this framework, we characterize evaluation functions allowing for compromises between the classical quality-adjusted life years (QALYs) and its polar productivity-adjusted life years (PALYs). Our framework and characterization results provide a new normative basis for the economic evaluation of health care interventions, as well as occupational health and safety policies, aimed to impact both health and productivity of individuals.

Published
2024

2. Impact of smoking in patients with suspected coronary artery disease in the randomised DISCHARGE trial

Author

Mancone, Massimo, Mézquita, Aldo J. Vázquez, Birtolo, Lucia Ilaria, Maurovich-Horvat, Pal, Kofoed, Klaus F., Benedek, Theodora, Donnelly, Patrick, Rodriguez-Palomares, Jose, Erglis, Andrejs, Štěchovský, Cyril, Šakalytė, Gintare, Ađić, Nada Čemerlić, Gutberlet, Matthias, Diez, Ignacio, Davis, Gershan, Zimmermann, Elke, Kępka, Cezary, Vidakovic, Radosav, Francone, Marco, Ilnicka-Suckiel, Małgorzata, Plank, Fabian, Knuuti, Juhanni, Faria, Rita, Schröder, Stephen, Berry, Colin, Saba, Luca, Ruzsics, Balazs, Rieckmann, Nina, Kubiak, Christine, Hansen, Kristian Schultz, Müller-Nordhorn, Jaqueline, Merkely, Bela, Sigvardsen, Per E., Benedek, Imre, Orr, Clare, Valente, Filipa Xavier, Zvaigzne, Ligita, Suchánek, Vojtěch, Jankauskas, Antanas, Ađić, Filip, Woinke, Michael, Keane, Stephen, Lecumberri, Ignacio, Thwaite, Erica, Kruk, Mariusz, Jovanovic, Vladimir, Kuśmierz, Donata, Feuchtner, Gudren, Pietilä, Mikko, Ribeiro, Vasco Gama, Drosch, Tanja, Delles, Christian, Palmisano, Vitanio, Fisher, Michael, Drobni, Zsófia D., Kragelund, Charlotte, Aurelian, Rosca, Kelly, Stephanie, del Blanco, Bruno Garcia, Rubio, Ainhoa, Boussoussou, Melinda, Hove, Jens D., Rodean, Ioana, Regan, Susan, Calabria, Hug Cuéllar, Becker, Dávid, Larsen, Linnea, Hodas, Roxana, Napp, Adriane E., Haase, Robert, Feger, Sarah, Mohamed, Mahmoud, Neumann, Konrad, Dreger, Henryk, Rief, Matthias, Wieske, Viktoria, Douglas, Pamela S., Estrella, Melanie, Bosserdt, Maria, Martus, Peter, Serna-Higuita, Lina M., Dodd, Jonathan D., and Dewey, Marc

Published
2024
Full Text
View/download PDF

5. Erratum. Computed Tomography Versus Invasive Coronary Angiography in Patients With Diabetes and Suspected Coronary Artery Disease. Diabetes Care 2023;46:2015–2023

Author

Benedek, Theodora, primary, Wieske, Viktoria, additional, Szilveszter, Bálint, additional, Kofoed, Klaus F., additional, Donnelly, Patrick, additional, Rodriguez-Palomares, José, additional, Erglis, Andrejs, additional, Veselka, Josef, additional, Šakalytė, Gintarė, additional, Ađić, Nada Čemerlić, additional, Gutberlet, Matthias, additional, Diez, Ignacio, additional, Davis, Gershan, additional, Zimmermann, Elke, additional, Kępka, Cezary, additional, Vidakovic, Radosav, additional, Francone, Marco, additional, Ilnicka-Suckiel, Małgorzata, additional, Plank, Fabian, additional, Knuuti, Juhani, additional, Faria, Rita, additional, Schröder, Stephen, additional, Berry, Colin, additional, Saba, Luca, additional, Ruzsics, Balazs, additional, Rieckmann, Nina, additional, Kubiak, Christine, additional, Hansen, Kristian Schultz, additional, Müller-Nordhorn, Jacqueline, additional, Merkely, Bela, additional, Sigvardsen, Per E., additional, Benedek, Imre, additional, Orr, Clare, additional, Valente, Filipa Xavier, additional, Zvaigzne, Ligita, additional, Horváth, Martin, additional, Jankauskas, Antanas, additional, Ađić, Filip, additional, Woinke, Michael, additional, Mulvihill, Niall, additional, Lecumberri, Iñigo, additional, Thwaite, Erica, additional, Laule, Michael, additional, Kruk, Mariusz, additional, Stefanovic, Milica, additional, Mancone, Massimo, additional, Kuśmierz, Donata, additional, Feuchtner, Gudrun, additional, Pietilä, Mikko, additional, Ribeiro, Vasco Gama, additional, Drosch, Tanja, additional, Delles, Christian, additional, Melis, Marco, additional, Fisher, Michael, additional, Boussoussou, Melinda, additional, Kragelund, Charlotte, additional, Aurelian, Rosca, additional, Kelly, Stephanie, additional, Blanco, Bruno Garcia del, additional, Rubio, Ainhoa, additional, Károlyi, Mihály, additional, Hove, Jens D., additional, Rodean, Ioana, additional, Regan, Susan, additional, Calabria, Hug Cuéllar, additional, Gellér, László, additional, Larsen, Linnea, additional, Hodas, Roxana, additional, Napp, Adriane E., additional, Haase, Robert, additional, Feger, Sarah, additional, Mohamed, Mahmoud, additional, Serna-Higuita, Lina M., additional, Neumann, Konrad, additional, Dreger, Henryk, additional, Rief, Matthias, additional, Danesh, John, additional, Estrella, Melanie, additional, Bosserdt, Maria, additional, Martus, Peter, additional, Dodd, Jonathan D., additional, and Dewey, Marc, additional

Published
2024
Full Text
View/download PDF

9. Development of Zalfermin, a Long-Acting Proteolytically Stabilized FGF21 Analog

Author

Sass-Ørum, Kristian, Tagmose, Tina Møller, Olsen, Jørgen, Sjölander, Annika, Wahlund, Per-Olof, Han, Dan, Vegge, Andreas, Reedtz-Runge, Steffen, Wang, Zhe, Gao, Xiang, Wieczorek, Birgit, Lamberth, Kasper, Lykkegaard, Kirsten, Nielsen, Peter Kresten, Thøgersen, Henning, Yu, Mingrui, Wang, Jianhua, Drustrup, Jørn, Zhang, Xujia, Garibay, Patrick, Hansen, Kristian, Hansen, Ann Maria Kruse, and Andersen, Birgitte

Abstract

Here, we describe the development of the FGF21 analog zalfermin (NNC0194-0499, 15), intended for once-weekly sc dosing. Protein engineering was needed to address inherent druggability issues of the natural FGF21 hormone. Thus, deamidation of Asp121 was solved by mutation to glutamine, and oxidation of Met168 was solved by mutation to leucine. N-terminal region degradation by dipeptidyl peptidase IV was prevented by alanine residue elongation. To prevent inactivating metabolism by fibroblast activation protein and carboxypeptidase-like activity in the C-terminal region, and to achieve t1/2extension (53 h in cynomolgus monkeys), we introduced a C18 fatty diacid at the penultimate position 180. The fatty diacid binds albumin in a reversible manner, such that the free fraction of zalfermin potently activates the FGF-receptor complex and retains receptor selectivity compared with FGF21, providing strong efficacy on body weight loss in diet-induced obese mice. Zalfermin is currently being clinically evaluated for the treatment of metabolic dysfunction-associated steatohepatitis.

Published
2024
Full Text
View/download PDF

10. Not so 'dumb money'? Constituting professionals and amateurs in the history of finance capitalism.

Author

Hansen, Kristian Bondo and Komporozos-Athanasiou, Aris

Subjects
*PROFESSIONAL employees, *AMATEURS, *FINANCE capitalism, *BUSINESS journalism, *FINANCIAL markets
Abstract

This article examines the historically contentious relationship between the financial market and the public as discussed in academic literature, financial journalism and prescriptive how-to invest handbooks during the late 19th and early 20th centuries. Although financial markets thrive off active public participation, speculating at stock and commodity exchanges has been a sanctioned ritual reserved for a privileged minority. We argue that the financial establishment's intent to control market access through financial entry-barriers (such as exchange membership fees and margin requirements) has been part of a bigger story we need to understand: a history of delegitimating uninitiated 'lay speculators' through the construction of exclusionary narratives about unfit amateur investors and morally corrupt publics. We conceptualize this process as an ongoing and delicate boundary-making exercise contributing to a market participation discourse that has been characterized by a set of reductive binaries, such as those of insider–outsider, professional–amateur and speculator–gambler. We show, however, that attempts to delineate popular participation in financial markets through these binaries have been complicated by the idea that besides being a force of market instability and collective irrationality, the public was a largely untapped source of liquidity. We argue that today's discourse on public participation in financial markets resuscitates these simplified narratives and propose a more nuanced view of non-professional market participants being both destabilizers and liquidity-providers. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

12. The Best Way to Reduce Discards Is by Not Catching Them!

Author

Reid, David G., Calderwood, Julia, Afonso, Pedro, Bourdaud, Pierre, Fauconnet, Laurence, González-Irusta, José Manuel, Mortensen, Lars O., Ordines, Francesc, Lehuta, Sigrid, Pawlowski, Lionel, Plet-Hansen, Kristian S., Radford, Zachary, Robert, Marianne, Rochet, Marie-Joelle, Rueda, Lucía, Ulrich, Clara, Vermard, Youen, Uhlmann, Sven Sebastian, editor, Ulrich, Clara, editor, and Kennelly, Steven J., editor

Published
2019
Full Text
View/download PDF

13. Impact of smoking in patients with suspected coronary artery disease in the randomised DISCHARGE trial

Author

Mancone, Massimo, primary, Mézquita, Aldo J. Vázquez, additional, Birtolo, Lucia Ilaria, additional, Maurovich-Horvat, Pal, additional, Kofoed, Klaus F., additional, Benedek, Theodora, additional, Donnelly, Patrick, additional, Rodriguez-Palomares, Jose, additional, Erglis, Andrejs, additional, Štěchovský, Cyril, additional, Šakalytė, Gintare, additional, Ađić, Nada Čemerlić, additional, Gutberlet, Matthias, additional, Diez, Ignacio, additional, Davis, Gershan, additional, Zimmermann, Elke, additional, Kępka, Cezary, additional, Vidakovic, Radosav, additional, Francone, Marco, additional, Ilnicka-Suckiel, Małgorzata, additional, Plank, Fabian, additional, Knuuti, Juhanni, additional, Faria, Rita, additional, Schröder, Stephen, additional, Berry, Colin, additional, Saba, Luca, additional, Ruzsics, Balazs, additional, Rieckmann, Nina, additional, Kubiak, Christine, additional, Hansen, Kristian Schultz, additional, Müller-Nordhorn, Jaqueline, additional, Merkely, Bela, additional, Sigvardsen, Per E., additional, Benedek, Imre, additional, Orr, Clare, additional, Valente, Filipa Xavier, additional, Zvaigzne, Ligita, additional, Suchánek, Vojtěch, additional, Jankauskas, Antanas, additional, Ađić, Filip, additional, Woinke, Michael, additional, Keane, Stephen, additional, Lecumberri, Ignacio, additional, Thwaite, Erica, additional, Kruk, Mariusz, additional, Jovanovic, Vladimir, additional, Kuśmierz, Donata, additional, Feuchtner, Gudren, additional, Pietilä, Mikko, additional, Ribeiro, Vasco Gama, additional, Drosch, Tanja, additional, Delles, Christian, additional, Palmisano, Vitanio, additional, Fisher, Michael, additional, Drobni, Zsófia D., additional, Kragelund, Charlotte, additional, Aurelian, Rosca, additional, Kelly, Stephanie, additional, del Blanco, Bruno Garcia, additional, Rubio, Ainhoa, additional, Boussoussou, Melinda, additional, Hove, Jens D., additional, Rodean, Ioana, additional, Regan, Susan, additional, Calabria, Hug Cuéllar, additional, Becker, Dávid, additional, Larsen, Linnea, additional, Hodas, Roxana, additional, Napp, Adriane E., additional, Haase, Robert, additional, Feger, Sarah, additional, Mohamed, Mahmoud, additional, Neumann, Konrad, additional, Dreger, Henryk, additional, Rief, Matthias, additional, Wieske, Viktoria, additional, Douglas, Pamela S., additional, Estrella, Melanie, additional, Bosserdt, Maria, additional, Martus, Peter, additional, Serna-Higuita, Lina M., additional, Dodd, Jonathan D., additional, and Dewey, Marc, additional

Published
2023
Full Text
View/download PDF

17. Age and Computed Tomography and Invasive Coronary Angiography in Stable Chest Pain: A Prespecified Secondary Analysis of the DISCHARGE Randomized Clinical Trial

Author

Bosserdt, Maria, Serna-Higuita, Lina M., Feuchtner, Gudrun, Merkely, Bela, Kofoed, Klaus F., Benedek, Theodora, Donnelly, Patrick, Rodriguez-Palomares, José, Erglis, Andrejs, Štechovský, Cyril, Šakalyte, Gintare, Adic, Nada Cemerlic, Gutberlet, Matthias, Dodd, Jonathan D., Diez, Ignacio, Davis, Gershan, Zimmermann, Elke, Kepka, Cezary, Vidakovic, Radosav, Francone, Marco, Ilnicka-Suckiel, Malgorzata, Plank, Fabian, Knuuti, Juhani, Faria, Rita, Schröder, Stephen, Berry, Colin, Saba, Luca, Ruzsics, Balazs, Rieckmann, Nina, Kubiak, Christine, Hansen, Kristian Schultz, Müller-Nordhorn, Jacqueline, Szilveszter, Bálint, Sigvardsen, Per E., Benedek, Imre, Orr, Clare, Valente, Filipa Xavier, Zvaigzne, Ligita, Suchánek, Vojtech, Jankauskas, Antanas, Adic, Filip, Woinke, Michael, Hensey, Mark, Lecumberri, Iñigo, Thwaite, Erica, Laule, Michael, Kruk, Mariusz, Neskovic, Aleksandar N., Mancone, Massimo, Kusmierz, Donata, Pietilä, Mikko, Ribeiro, Vasco Gama, Drosch, Tanja, Delles, Christian, Porcu, Maurizio, Fisher, Michael, Boussoussou, Melinda, Kragelund, Charlotte, Aurelian, Rosca, Kelly, Stephanie, Garcia del Blanco, Bruno, Rubio, Ainhoa, Maurovich-Horvat, Pál, Hove, Jens D., Rodean, Ioana, Regan, Susan, Cuellar-Calabria, Hug, Molnár, Levente, Larsen, Linnea, Hodas, Roxana, Napp, Adriane E., Haase, Robert, Feger, Sarah, Mohamed, Mahmoud, Neumann, Konrad, Dreger, Henryk, Rief, Matthias, Wieske, Viktoria, Estrella, Melanie, Martus, Peter, Sox, Harold C., and Dewey, Marc

Abstract

IMPORTANCE: The effectiveness and safety of computed tomography (CT) and invasive coronary angiography (ICA) in different age groups is unknown. OBJECTIVE: To determine the association of age with outcomes of CT and ICA in patients with stable chest pain. DESIGN, SETTING, AND PARTICIPANTS: The assessor-blinded Diagnostic Imaging Strategies for Patients With Stable Chest Pain and Intermediate Risk of Coronary Artery Disease (DISCHARGE) randomized clinical trial was conducted between October 2015 and April 2019 in 26 European centers. Patients referred for ICA with stable chest pain and an intermediate probability of obstructive coronary artery disease were analyzed in an intention-to-treat analysis. Data were analyzed from July 2022 to January 2023. INTERVENTIONS: Patients were randomly assigned to a CT-first strategy or a direct-to-ICA strategy. MAIN OUTCOMES AND MEASURES: MACE (ie, cardiovascular death, nonfatal myocardial infarction, or stroke) and major procedure-related complications. The primary prespecified outcome of this secondary analysis of age was major adverse cardiovascular events (MACE) at a median follow-up of 3.5 years. RESULTS: Among 3561 patients (mean [SD] age, 60.1 [10.1] years; 2002 female [56.2%]), 2360 (66.3%) were younger than 65 years, 982 (27.6%) were between ages 65 to 75 years, and 219 (6.1%) were older than 75 years. The primary outcome was MACE at a median (IQR) follow-up of 3.5 (2.9-4.2) years for 3523 patients (99%). Modeling age as a continuous variable, age, and randomization group were not associated with MACE (hazard ratio, 1.02; 95% CI, 0.98-1.07; P for interaction = .31). Age and randomization group were associated with major procedure-related complications (odds ratio, 1.15; 95% CI, 1.05-1.27; P for interaction = .005), which were lower in younger patients. CONCLUSIONS AND RELEVANCE: Age did not modify the effect of randomization group on the primary outcome of MACE but did modify the effect on major procedure-related complications. Results suggest that CT was associated with a lower risk of major procedure-related complications in younger patients. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT02400229

Published
2024
Full Text
View/download PDF

18. Stack bricolage and infrastructural impermanence in financial machine-learning modelling.

Author

Hansen, Kristian Bondo and Thylstrup, Nanna

Subjects
MACHINE learning, COMMUNICATION infrastructure, SOCIAL finance, CLOUD computing, FINANCIAL markets
Abstract

Hoping that the promises of machine-learning can be realised in financial markets, investment management and trading firms increasingly employ machine-learning techniques to extract exploitable informational edge from large datasets. In addition to heavy investments in technology and the human resources capable of manipulating it, this development has led to increased use of open-source machine-learning and data-management resources. Drawing on 44 interviews with developers and users of machine-learning techniques in finance, we explore how such platforms and other open-source resources are understood and used by said practitioners. Building on work in the Social Studies of Finance (SSF) on financial modelling and platformisation, we argue that these users of machine learning in finance engage in what we term stack bricolage activities, when they reuse disparate open-source resources in their modelling work. We argue that stack bricolage creates dependencies on open-source cloud resources characterised by infrastructural impermanence, which is a result of their substitutability and maintenance sensitivity. Our study contributes to the emerging SSF literature on machine-learning modelling cultures and debates in Science and Technology Studies and adjacent fields on the reuse of data and software in platformised cloud infrastructures. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

19. The labor market costs of work-related stress: A longitudinal study of 52 763 Danish employees using multi-state modeling.

Author

Pedersen, Jacob, Krogh Graversen, Brian, Schultz Hansen, Kristian, and Huitfeldt Madsen, Ida Elisabeth

Abstract

The article focuses on the impact of work-related stress on labor market outcomes such as sickness absence, return to work probability, and early retirement, highlighting the scarcity of studies considering multiple labor outcomes and their interconnectivity, which could provide crucial insights into the relationship between recurrent sickness absence and decreased work participation.

Published
2024
Full Text
View/download PDF

20. CT versus Invasive Coronary Angiography in Patients With Diabetes and Suspected Coronary Artery Disease

Author

Benedek, Theodora, primary, Wieske, Viktoria, primary, Szilveszter, Bálint, primary, Kofoed, Klaus F, primary, Donnelly, Patrick, primary, Rodriguez-Palomares, José, primary, Erglis, Andrejs, primary, Veselka, Josef, primary, Šakalytė, Gintarė, primary, Čemerlić Ađić, Nada, primary, Gutberlet, Matthias, primary, Diez, Ignacio, primary, Davis, Gershan, primary, Zimmermann, Elke, primary, Kępka, Cezary, primary, Vidakovic, Radosav, primary, Francone, Marco, primary, Ilnicka-Suckiel,, Małgorzata, primary, Plank, Fabian, primary, Knuuti, Juhani, primary, Faria, Rita, primary, Schröder, Stephen, primary, Berry, Colin, primary, Saba, Luca, primary, Ruzsics, Balazs, primary, Rieckmann, Nina, primary, Kubiak, Christine, primary, Hansen, Kristian Schultz, primary, Müller-Nordhorn, Jacqueline, primary, Merkely, Bela, primary, Sigvardsen, Per E, primary, Benedek, Imre, primary, Orr, Clare, primary, Xavier Valente, Filipa, primary, Zvaigzne, Ligita, primary, Horváth, Martin, primary, Jankauskas, Antanas, primary, Ađić, Filip, primary, Woinke, Michael, primary, Mulvihill, Niall, primary, Lecumberri, Iñigo, primary, Thwaite, Erica, primary, Laule, Michael, primary, Kruk, Mariusz, primary, Stefanovic, Milica, primary, Mancone, Massimo, primary, Kuśmierz, Donata, primary, Feuchtner, Gudrun, primary, Pietilä, Mikko, primary, Ribeiro, Vasco Gama, primary, Drosch, Tanja, primary, Delles, Christian, primary, Melis, Marco, primary, Fisher, Michael, primary, Boussoussou, Melinda, primary, Kragelund, Charlotte, primary, Aurelian, Rosca, primary, Kelly, Stephanie, primary, del Blanco, Bruno Garcia, primary, Rubio, Ainhoa, primary, Károlyi, Mihály, primary, Hove, Jens D., primary, Rodean, Ioana, primary, Regan, Susan, primary, Cuéllar-Calabria, Hug, primary, Gellér, László, primary, Larsen, Solveig Linnea Veen, primary, Hodas, Roxana, primary, E. Napp, Adriane, primary, Haase, Robert, primary, Feger, Sarah, primary, Mohamed, Mahmoud, primary, M. Serna-Higuita, Lina, primary, Neumann, Konrad, primary, Dreger, Henryk, primary, Rief, Matthias, primary, Danesh, John, primary, Estrella, Melanie, primary, Bosserdt, Maria, primary, Martus, Peter, primary, D. Dodd, Jonathan, primary, and Dewey, Marc, primary

Published
2023
Full Text
View/download PDF

21. Computed Tomography Versus Invasive Coronary Angiography in Patients With Diabetes and Suspected Coronary Artery Disease

Author

Benedek, Theodora, primary, Wieske, Viktoria, additional, Szilveszter, Bálint, additional, Kofoed, Klaus F., additional, Donnelly, Patrick, additional, Rodriguez-Palomares, José, additional, Erglis, Andrejs, additional, Veselka, Josef, additional, Šakalytė, Gintarė, additional, Ađić, Nada Čemerlić, additional, Gutberlet, Matthias, additional, Diez, Ignacio, additional, Davis, Gershan, additional, Zimmermann, Elke, additional, Kępka, Cezary, additional, Vidakovic, Radosav, additional, Francone, Marco, additional, Ilnicka-Suckiel, Małgorzata, additional, Plank, Fabian, additional, Knuuti, Juhani, additional, Faria, Rita, additional, Schröder, Stephen, additional, Berry, Colin, additional, Saba, Luca, additional, Ruzsics, Balazs, additional, Rieckmann, Nina, additional, Kubiak, Christine, additional, Schultz Hansen, Kristian, additional, Müller-Nordhorn, Jacqueline, additional, Merkely, Bela, additional, Sigvardsen, Per E., additional, Benedek, Imre, additional, Orr, Clare, additional, Valente, Filipa Xavier, additional, Zvaigzne, Ligita, additional, Horváth, Martin, additional, Jankauskas, Antanas, additional, Ađić, Filip, additional, Woinke, Michael, additional, Mulvihill, Niall, additional, Lecumberri, Iñigo, additional, Thwaite, Erica, additional, Laule, Michael, additional, Kruk, Mariusz, additional, Stefanovic, Milica, additional, Mancone, Massimo, additional, Kuśmierz, Donata, additional, Feuchtner, Gudrun, additional, Pietilä, Mikko, additional, Ribeiro, Vasco Gama, additional, Drosch, Tanja, additional, Delles, Christian, additional, Melis, Marco, additional, Fisher, Michael, additional, Boussoussou, Melinda, additional, Kragelund, Charlotte, additional, Aurelian, Rosca, additional, Kelly, Stephanie, additional, Garcia del Blanco, Bruno, additional, Rubio, Ainhoa, additional, Károlyi, Mihály, additional, Hove, Jens D., additional, Rodean, Ioana, additional, Regan, Susan, additional, Calabria, Hug Cuéllar, additional, Gellér, László, additional, Larsen, Linnea, additional, Hodas, Roxana, additional, Napp, Adriane E., additional, Haase, Robert, additional, Feger, Sarah, additional, Mohamed, Mahmoud, additional, Serna-Higuita, Lina M., additional, Neumann, Konrad, additional, Dreger, Henryk, additional, Rief, Matthias, additional, Danesh, John, additional, Estrella, Melanie, additional, Bosserdt, Maria, additional, Martus, Peter, additional, Dodd, Jonathan D., additional, and Dewey, Marc, additional

Published
2023
Full Text
View/download PDF

22. Trapping of light pulses in ensembles of stationary Lambda atoms

Author

Hansen, Kristian Rymann and Molmer, Klaus

Subjects
Quantum Physics
Abstract

We present a detailed theoretical description of the generation of stationary light pulses by standing wave electromagnetically induced transparency in media comprised of stationary atoms. We show that, contrary to thermal gas media, the achievable storage times are limited only by the ground state dephasing rate of the atoms, making such media ideally suited for nonlinear optical interactions between stored pulses. Furthermore, we find significant quantitative and qualitative differences between the two types of media, which are important for quantum information processing schemes involving stationary light pulses., Comment: 10 pages, 4 figures

Published
2007

23. Stationary light pulses in ultra cold atomic gasses

Author

Hansen, Kristian Rymann and Molmer, Klaus

Subjects
Quantum Physics
Abstract

We present a theoretical treatment of electromagnetically induced transparency and light storage using standing wave coupling fields in a medium comprised of stationary atoms, such as an ultra cold atomic gas or a solid state medium. We show that it is possible to create stationary pulses of light which have a qualitatively different behavior than in the case of a thermal gas medium, offering greater potential for quantum information processing applications., Comment: 4 pages, 3 figures

Published
2006

31. Tools and Technologies for the Monitoring, Control and Surveillance of Unwanted Catches

Author

James, Kelly M., primary, Campbell, Neill, additional, Viðarsson, Jónas R., additional, Vilas, Carlos, additional, Plet-Hansen, Kristian S., additional, Borges, Lisa, additional, González, Óscar, additional, van Helmond, Aloysius T. M., additional, Pérez-Martín, Ricardo I., additional, Antelo, Luis Taboada, additional, Pérez-Bouzada, Jorge, additional, and Ulrich, Clara, additional

Published
2018
Full Text
View/download PDF

32. The Best Way to Reduce Discards Is by Not Catching Them!

Author

Reid, David G., primary, Calderwood, Julia, additional, Afonso, Pedro, additional, Bourdaud, Pierre, additional, Fauconnet, Laurence, additional, González-Irusta, José Manuel, additional, Mortensen, Lars O., additional, Ordines, Francesc, additional, Lehuta, Sigrid, additional, Pawlowski, Lionel, additional, Plet-Hansen, Kristian S., additional, Radford, Zachary, additional, Robert, Marianne, additional, Rochet, Marie-Joelle, additional, Rueda, Lucía, additional, Ulrich, Clara, additional, and Vermard, Youen, additional

Published
2018
Full Text
View/download PDF

33. GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand

Author

Yang, Linda, Chang, Chih-Chuan, Sun, Zhe, Madsen, Dennis, Zhu, Haisun, Padkjaer, Søren B, Wu, Xiaoai, Huang, Tao, Hultman, Karin, Paulsen, Sarah J, Wang, Jishu, Bugge, Anne, Frantzen, Jane Boesen, Nørgaard, Per, Jeppesen, Jacob Fuglsbjerg, Yang, Zhiru, Secher, Anna, Chen, Haibin, Li, Xun, John, Linu Mary, Shan, Bing, He, Zhenhua, Gao, Xiang, Su, Jing, Hansen, Kristian T, Yang, Wei, and Jørgensen, Sebastian Beck

Subjects
Obesity -- Genetic aspects -- Care and treatment, Signaling peptides and proteins -- Health aspects, Gene expression -- Health aspects, Biological sciences, Health
Abstract

Growth differentiation factor 15 (GDF15; also known as MIC-1) is a divergent member of the TGF-[beta] superfamily and is associated with body-weight regulation in humans and rodents. However, the cognate receptor of GDF15 is unknown. Here we show that GDF15 binds specifically to GDNF family receptor [alpha]-like (GFRAL) with high affinity, and that GFRAL requires association with the coreceptor RET to elicit intracellular signaling in response to GDF15 stimulation. We also found that GDF15-mediated reductions in food intake and body weight of mice with obesity were abolished in GFRAL-knockout mice. We further found that GFRAL expression was limited to hindbrain neurons and not present in peripheral tissues, which suggests that GDF15-GFRAL-mediated regulation of food intake is by a central mechanism. Lastly, given that GDF15 did not increase energy expenditure in treated mice with obesity, the anti-obesity actions of the cytokine are likely driven primarily by a reduction in food intake., Author(s): Linda Yang [1]; Chih-Chuan Chang [1]; Zhe Sun [1]; Dennis Madsen [2]; Haisun Zhu [1]; Søren B Padkjaer [2]; Xiaoai Wu [1]; Tao Huang [1]; Karin Hultman [2]; Sarah [...]

Published
2017
Full Text
View/download PDF

34. CT or Invasive Coronary Angiography in Stable Chest Pain

Author

Maurovich-Horvat, Pal, Bosserdt, Maria, Kofoed, Klaus F., Rieckmann, Nina, Benedek, Theodora, Donnelly, Patrick, Rodriguez-Palomares, Jose, Erglis, Andrejs, Stechovsk, Cyril, Sakalyte, Gintare, Adic, Nada Cemerlic, Gutberlet, Matthias, Dodd, Jonathan D., Diez, Ignacio, Davis, Gershan, Zimmermann, Elke, Kepka, Cezary, Vidakovic, Radosav, Francone, Marco, Ilnicka-Suckiel, Malgorzata, Plank, Fabian, Knuuti, Juhani, Faria, Rita, Schroder, Stephen, Berry, Colin, Saba, Luca, Ruzsics, Balazs, Kubiak, Christine, Gutierrez-Ibarluzea, Inaki, Hansen, Kristian Schultz, Muller-Nordhorn, Jacqueline, Merkely, Bela, Knudsen, Andreas D., Benedek, Imre, Orr, Clare, Valente, Filipa Xavier, Zvaigzne, Ligita, Suchanek, Vojtech, Zajanckauskiene, Laura, Adic, Flip, Woinke, Michael, Hensey, Mark, Lecumberri, Inigo, Thwaite, Erica, Laule, Michael, Kruk, Mariusz, Neskovic, Aleksandar N., Larsen, Linnea, Jurlander, Birgit, and Engstrom, Thomas

Subjects
ANGINA, MANAGEMENT, PCI, General Medicine, GUIDELINES
Abstract

BACKGROUNDIn the diagnosis of obstructive coronary artery disease (CAD), computed tomography (CT) is an accurate, noninvasive alternative to invasive coronary angiography (ICA). However, the comparative effectiveness of CT and ICA in the management of CAD to reduce the frequency of major adverse cardiovascular events is uncertain.METHODSWe conducted a pragmatic, randomized trial comparing CT with ICA as initial diagnostic imaging strategies for guiding the treatment of patients with stable chest pain who had an intermediate pretest probability of obstructive CAD and were referred for ICA at one of 26 European centers. The primary outcome was major adverse cardiovascular events (cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke) over 3.5 years. Key secondary outcomes were procedure-related complications and angina pectoris.RESULTSAmong 3561 patients (56.2% of whom were women), follow-up was complete for 3523 (98.9%). Major adverse cardiovascular events occurred in 38 of 1808 patients (2.1%) in the CT group and in 52 of 1753 (3.0%) in the ICA group (hazard ratio, 0.70; 95% confidence interval [CI), 0.46 to 1.07; P=0.10). Major procedure-related complications occurred in 9 patients (0.5%) in the CT group and in 33 (1.9%) in the ICA group (hazard ratio, 0.26; 95% CI, 0.13 to 0.55). Angina during the final 4 weeks of follow-up was reported in 8.8% of the patients in the CT group and in 7.5% of those in the ICA group (odds ratio, 1.17; 95% CI, 0.92 to 1.48).CONCLUSIONSAmong patients referred for ICA because of stable chest pain and intermediate pretest probability of CAD, the risk of major adverse cardiovascular events was similar in the CT group and the ICA group. The frequency of major procedure-related complications was lower with an initial CT strategy.

Published
2022

37. Veien til en vellykket ERP-implementering ved bruk av systemutviklingsmetodikk

Author

Johansson, Bendik Østerlie, Bygland-Hansen, Kristian, and Holum, Marthe

Abstract

Stadig flere virksomheter tar i bruk moderne skybaserte ERP-systemer. Siden ERP-systemer er ende-til-ende løsninger som omfatter funksjonalitet på tvers av en hel virksomhet, er et ERP-prosjekt svært omfattende. Implementering av ERP-systemet D365 i Veidekke Industri understreker dette. En metodisk tilnærming til ERP-prosjekter synes å være hensiktsmessig, hvor det tidligere er gjort mye forskning på valg av systemutviklingsmetodikk. Mindre forskning synes imidlertid å være dedikert til valg av metodikk ved utvikling og implementering av ERP-systemer. Denne kvalitative studien har undersøkt hvordan systemutviklingsmetodikk kan anvendes for å øke sjansene for å lykkes med ERP-implementering, med utgangspunkt i en casestudie. Studiet har benyttet teori om IS/IT-prosjekter, ERP-systemer og ulike metoder for systemutvikling. Resultatene viser at en kombinasjon av disse teoriene kan være relevant for å svare på problemstillingen, og at det er behov for å studere valg av systemutviklingsmetodikk ved ERP-prosjekter mer grundig. Studiet har identifisert spesifikke hensyn som må ivaretas ved ERP-implementering, i tillegg til at IT i seg selv ikke er verdiskapende uten tilpasning til virksomhetens behov. En viktig faktor synes å være virksomhetens evne til å balansere de to motstridende behovene - stabilitet og agilitet, ved tilpassing av den anvendte metoden. Casestudien belyser utfordringene som oppstår når prosjektet er preget av tidspress og manglende forankring i forretningsmessige behov. Dette kan føre til begrenset forståelse for prosjektets omfang, budsjettoverskridelser og utfordringer ved utvikling og implementering. Ved initiering av et ERP-prosjekt er det essensielt å dokumentere kravspesifikasjoner forankret i forretningsmessige behov. Kravspesifikasjonene danner grunnlag for en minimumsløsning, med grunnleggende funksjonalitet, som bør være tilstrekkelig testet før implementering. Elementer fra tradisjonell systemutvikling kan være relevant for å sikre dette. For å realisere gevinster ved bruk av ERP-systemer, virker et tett samarbeid med brukerne og en utforskende tilnærming til utvikling å være hensiktsmessig. Utvikling av brukergrensesnitt, applikasjoner og ytterligere funksjonalitet er deler av ERP-systemet som anses som mindre kritiske. For dette fremstår elementer og prinsipper fra agil systemutvikling å være hensiktsmessig. More and more businesses are adopting modern cloud-based ERP systems. Since ERP systems are end-to-end solutions that encompass functionality across an entire enterprise, an ERP project is highly comprehensive. The implementation of the ERP system D365 in Veidekke Industri emphasizes this. A methodical approach to ERP projects seems to be appropriate, where much research has previously been done on the selection of system development methodology. However, little research seems to be dedicated to the choice of methodology for the development and implementation of ERP systems. This qualitative study has investigated how system development methodology can be utilized to increase the chances of success in ERP implementation, based on a case study. The study is based on theory on IS/IT projects, ERP systems, and various methods for system development. The results show that a combination of these theories may be relevant to answer the research question, and that there is a need to study the selection of system development methodology in ERP-projects more thoroughly. The study has identified specific considerations that must be considered in ERP implementation, and that IT inherits no value without adaptation to the company's needs. An important factor seems to be the company's ability to balance the two conflicting needs - stability and agility, by adapting the applied method. The case study highlights the challenges that arise when a project is characterized by time pressure and lack of anchoring in business needs. This can lead to limited understanding of the project scope, budget overruns, and challenges in development and implementation. When initiating an ERP project, it is essential to document requirement specifications anchored in business needs. The requirement specifications form the basis for a minimum viable product, with basic functionality, which should be sufficiently tested before implementation. Elements from traditional system development may be relevant to ensure this. To realize the benefits of using ERP systems, close collaboration with users and an exploratory approach to development seem appropriate. Development of user interfaces, applications, and additional functionality are parts of the ERP-system that are considered less critical. For this, elements and principles from agile system development seem suitable.

Published
2023

38. Expectations, competencies and domain knowledge in data- and machine-driven finance.

Author

Hansen, Kristian Bondo and Souleles, Daniel

Subjects
FINANCIAL markets, VALUATION, DATA science
Abstract

Expectations about the economy and financial markets are often cast as figments of imaginaries of the future. While the sociology of finance have predominantly dealt with expectation formation in relation to calculative devices used in practices of valuation and prediction, this paper concerns the expectations finance professionals form about their work in data- and machine-driven finance. We examine how high-skilled professionals reflexively form expectations about their work and argue that techno-centric imaginaries of the future of finance tend to create an emphasis on domain-independent data science skills over financial domain knowledge. However, we show that such imaginaries do not necessarily perform the work-related expectations of financial professionals, but are instead challenged and nuanced in reflections about the value of practice-bound domain knowledge and expertise. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

39. Evaluation of a novel heparin-iloprost-based antithrombotic formulation blood collection tube for clinical usage

Author

Radziwon-Balicka, Aneta, primary, Wiwe, Elias F, additional, Jensen, Tomas Ø, additional, Nielsen, Signe G, additional, Copois, Miljena, additional, Sunde, Niclas, additional, Peytz, Nina C, additional, Al-Mousawi, Dhergam A.A., additional, Hansen, Mie C, additional, Petersen, Jesper F, additional, Nørskov, Anne S, additional, Lendorf, Maria E, additional, Hansen, Young B.L., additional, Hansen, Thomas S, additional, Burkhardt, Melanie A, additional, Hansen, Kristian M, additional, and Jensen, Claus A.J., additional

Published
2022
Full Text
View/download PDF

47. Boneless Pose Editing and Animation

Author

Bærentzen, J. Andreas, Hansen, Kristian Evers, Erleben, Kenny, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Rangan, C. Pandu, editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Ersbøll, Bjarne Kjær, editor, and Pedersen, Kim Steenstrup, editor

Published
2007
Full Text
View/download PDF

48. Effect of allogeneic adipose tissue‐derived mesenchymal stromal cell treatment in chronic ischaemic heart failure with reduced ejection fraction – the SCIENCE trial.

Author

Qayyum, Abbas Ali, van Klarenbosch, Bas, Frljak, Sabina, Cerar, Andraz, Poglajen, Gregor, Traxler‐Weidenauer, Denise, Nadrowski, Pawel, Paitazoglou, Christina, Vrtovec, Bojan, Bergmann, Martin W., Chamuleau, Steven A. J., Wojakowski, Wojtek, Gyöngyösi, Mariann, Kraaijeveld, Adriaan, Hansen, Kristian Schultz, Vrangbæk, Karsten, Jørgensen, Erik, Helqvist, Steffen, Joshi, Francis Richard, and Johansen, Ellen Mønsted

Subjects
BRAIN natriuretic factor, STROMAL cells, HEART failure, VENTRICULAR ejection fraction, ADIPOSE tissue diseases, CARDIAC patients
Abstract

Aims: The aim of the SCIENCE trial was to investigate whether a single treatment with direct intramyocardial injections of adipose tissue‐derived mesenchymal stromal cells (CSCC_ASCs) was safe and improved cardiac function in patients with chronic ischaemic heart failure with reduced ejection fraction (HFrEF). Methods and results: The study was a European multicentre, double‐blind, placebo‐controlled phase II trial using allogeneic CSCC_ASCs from healthy donors or placebo (2:1 randomization). Main inclusion criteria were New York Heart Association (NYHA) class II–III, left ventricular ejection fraction (LVEF) <45%, and N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP) levels >300 pg/ml. CSCC_ASCs or placebo (isotonic saline) were injected directly into viable myocardium. The primary endpoint was change in left ventricular end‐systolic volume (LVESV) at 6‐month follow‐up measured by echocardiography. A total of 133 symptomatic HFrEF patients were included. The treatment was safe without any drug‐related severe adverse events or difference in cardiac‐related adverse events during a 3‐year follow‐up period. There were no significant differences between groups during follow‐up in LVESV (0.3 ± 5.0 ml, p = 0.945), nor in secondary endpoints of left ventricular end‐diastolic volume (−2.0 ± 6.0 ml, p = 0.736) and LVEF (−1.6 ± 1.0%, p = 0.119). The NYHA class improved slightly within the first year in both groups without any difference between groups. There were no changes in 6‐min walk test, NT‐proBNP, C‐reactive protein or quality of life the first year in any groups. Conclusion: The SCIENCE trial demonstrated safety of intramyocardial allogeneic CSCC_ASC therapy in patients with chronic HFrEF. However, it was not possible to improve the pre‐defined endpoints and induce restoration of cardiac function or clinical symptoms. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results