Search

Your search keyword '"Hansen, Henrik S."' showing total 40 results
Start Over Author "Hansen, Henrik S."
40 results on '"Hansen, Henrik S."'

1. Comparison of Durable-Polymer Zotarolimus-Eluting and Biodegradable-Polymer Biolimus-Eluting Coronary Stents in Patients With Coronary Artery Disease: 3-Year Clinical Outcomes in the Randomized SORT OUT VI Trial

Author

Raungaard, Bent, Thygesen, Kristian, Sørensen, Jacob Thorsted, Nørgaard, Bjarne Linde, Andersen, Søren Lindholt, Madsen, Morten, Jensen, Svend Eggert, Christiansen, Evald Høj, Bøtker, Hans Erik, Hansen, Henrik Steen, Jensen, Lisette Okkels, Christiansen, Evald H., Hansen, Henrik S., Ravkilde, Jan, Thuesen, Leif, Aarøe, Jens, Villadsen, Anton B., Terkelsen, Christian J., Krusell, Lars R., Maeng, Michael, Kristensen, Steen D., Veien, Karsten T., Hansen, Knud N., Junker, Anders, Andersen, Søren L., Jensen, Svend E., and Jensen, Lisette O.

Published
2017
Full Text
View/download PDF

3. Impact of acute coronary syndrome on clinical outcomes after revascularization with the dual‐therapy CD34 antibody‐covered sirolimus‐eluting Combo stent and the sirolimus‐eluting Orsiro stent

Author

Jakobsen, Lars, primary, Christiansen, Evald H., additional, Freeman, Phillip, additional, Kahlert, Johnny, additional, Veien, Karsten, additional, Maeng, Michael, additional, Raungaard, Bent, additional, Ellert, Julia, additional, Kristensen, Steen D., additional, Christensen, Martin K., additional, Terkelsen, Christian J., additional, Thim, Troels, additional, Eftekhari, Ashkan, additional, Jensen, Rebekka V., additional, Støttrup, Nicolaj B., additional, Junker, Anders, additional, Hansen, Henrik S., additional, and Jensen, Lisette O., additional

Published
2022
Full Text
View/download PDF

5. Impact of diabetes on clinical outcomes after revascularization with the dual therapy CD34 antibody‐covered sirolimus‐eluting Combo stent and the sirolimus‐eluting Orsiro stent

Author

Jakobsen, Lars, primary, Christiansen, Evald H., additional, Freeman, Phillip, additional, Kahlert, Johnny, additional, Veien, Karsten, additional, Maeng, Michael, additional, Raungaard, Bent, additional, Ellert, Julia, additional, Kristensen, Steen D., additional, Christensen, Martin K., additional, Terkelsen, Christian J., additional, Thim, Troels, additional, Eftekhari, Ashkan, additional, Jensen, Rebekka V., additional, Støttrup, Nicolaj B., additional, Junker, Anders, additional, Hansen, Henrik S., additional, and Jensen, Lisette O., additional

Published
2022
Full Text
View/download PDF

6. Impact of acute coronary syndrome on clinical outcomes after revascularization with the dual‐therapy CD34 antibody‐covered sirolimus‐eluting Combo stent and the sirolimus‐eluting Orsiro stent.

Author

Jakobsen, Lars, Christiansen, Evald H., Freeman, Phillip, Kahlert, Johnny, Veien, Karsten, Maeng, Michael, Raungaard, Bent, Ellert, Julia, Kristensen, Steen D., Christensen, Martin K., Terkelsen, Christian J., Thim, Troels, Eftekhari, Ashkan, Jensen, Rebekka V., Støttrup, Nicolaj B., Junker, Anders, Hansen, Henrik S., and Jensen, Lisette O.

Published
2023
Full Text
View/download PDF

8. Randomized Clinical Comparison of the Dual-Therapy CD34 Antibody-Covered Sirolimus-Eluting Combo Stent With the Sirolimus-Eluting Orsiro Stent in Patients Treated With Percutaneous Coronary Intervention: The SORT OUT X Trial

Author

Jakobsen, Lars, primary, Christiansen, Evald H., additional, Freeman, Phillip, additional, Kahlert, Johnny, additional, Veien, Karsten, additional, Maeng, Michael, additional, Raungaard, Bent, additional, Ellert, Julia, additional, Villadsen, Anton B., additional, Kristensen, Steen D., additional, Ahlehoff, Ole, additional, Christensen, Martin K., additional, Terkelsen, Christian J., additional, Erik Bøtker, Hans, additional, Aaroe, Jens, additional, Thim, Troels, additional, Thuesen, Leif, additional, Aziz, Ahmed, additional, Eftekhari, Ashkan, additional, Jensen, Rebekka V., additional, Støttrup, Nicolaj B., additional, Rasmussen, Jeppe G., additional, Junker, Anders, additional, Jensen, Svend E., additional, Hansen, Henrik S., additional, and Jensen, Lisette O., additional

Published
2021
Full Text
View/download PDF

9. Myocardial CT perfusion compared with transthoracic Doppler echocardiography in evaluation of the coronary microvascular function:An iPOWER substudy

Author

Bechsgaard, Daria F., Hove, Jens D., Michelsen, Marie M., Mygind, Naja D., Pena, Adam, Hansen, Peter R., Hansen, Henrik S., Kastrup, Jens, Høst, Nis, Gustafsson, Ida, Prescott, Eva, Bechsgaard, Daria F., Hove, Jens D., Michelsen, Marie M., Mygind, Naja D., Pena, Adam, Hansen, Peter R., Hansen, Henrik S., Kastrup, Jens, Høst, Nis, Gustafsson, Ida, and Prescott, Eva

Abstract

Background A significant number of women with angina and no obstructive coronary artery disease (CAD; <50% stenosis) have coronary microvascular dysfunction (CMD) which carries an adverse cardiovascular prognosis. Coronary microvascular function can be evaluated by transthoracic Doppler echocardiography (TTDE) as a coronary flow velocity reserve (CFVR) and by static CT myocardial perfusion (CTP) as a myocardial perfusion reserve (MPR). Whether these methods are correlated is not known. We assessed the correlation between CFVR and MPR and investigated whether women with angina, CMD and no obstructive CAD have reduced MPR compared with asymptomatic women. Methods Static CTP with adenosine-induced vasodilation and TTDE of the left anterior descending artery with dipyridamole-induced vasodilation were successfully performed and analysed in 99 women with stable angina and no obstructive CAD and 33 asymptomatic women with no obstructive CAD. CMD was defined as CFVR < 2. Results Correlation between rate-pressure product corrected MPR and CFVR was weak but significant (r = .23; p = .007). MPR was highest among asymptomatic women with normal CFVR (median [interquartile range; IQR] 158 [145–181] %). Symptomatic women with normal CFVR had reduced MPR (148 [134–162] %; age-adjusted p < .001); however, the lowest MPR was found in symptomatic women with CMD (140 [129–164] %; age-adjusted p < .001), independent of cardiovascular risk factors and haemodynamic parameters (p = .017). Conclusion Women with angina, CMD and no obstructive CAD had markedly diminished MPR compared with asymptomatic women. Correlation between CFVR and MPR was weak, suggesting that CTP and TTDE are not interchangeable for detection of CMD.

Published
2021

10. Myocardial CT perfusion compared with transthoracic Doppler echocardiography in evaluation of the coronary microvascular function: An iPOWER substudy

Author

Bechsgaard, Daria F., primary, Hove, Jens D., additional, Michelsen, Marie M., additional, Mygind, Naja D., additional, Pena, Adam, additional, Hansen, Peter R., additional, Hansen, Henrik S., additional, Kastrup, Jens, additional, Høst, Nis, additional, Gustafsson, Ida, additional, and Prescott, Eva, additional

Published
2020
Full Text
View/download PDF

11. 16-year follow-up of the Danish Acute Myocardial Infarction 2 (DANAMI-2) trial:Primary percutaneous coronary intervention vs. fibrinolysis in ST-segment elevationmyocardial infarction

Author

Thrane, Pernille G., Kristensen, Steen D., Olesen, Kevin K.W., Mortense, Leif S., Bøtker, Hans Erik, Thuesen, Leif, Hansen, Henrik S., Abildgaard, Ulrik, Engstrøm, Thomas, Andersen, Henning R., Maeng, Michael, Thrane, Pernille G., Kristensen, Steen D., Olesen, Kevin K.W., Mortense, Leif S., Bøtker, Hans Erik, Thuesen, Leif, Hansen, Henrik S., Abildgaard, Ulrik, Engstrøm, Thomas, Andersen, Henning R., and Maeng, Michael

Abstract

Aims The DANish Acute Myocardial Infarction 2 (DANAMI-2) trial found that interhospital transport to primary percutaneous coronary intervention (pPCI) was superior to fibrinolysis at the local hospital in patients with ST-segment elevation myocardial infarction (STEMI) at 30 days. The present study investigates the 16-year cardiovascular outcomes. Methods and results We randomized 1572 STEMI patients to pPCI or fibrinolysis at 24 referral hospitals and 5 invasive centres in Denmark. Patients randomized to pPCI at referral hospitals were immediately transported to the nearest invasive centre. The main endpoint of the current study was a composite of death or rehospitalization for myocardial infarction (MI). Outcome information beyond 3 years was obtained through Danish health registries. After 16 years, pPCI-treated patients had a sustained lower rate of composite endpoint compared to patients treated with fibrinolysis in the overall cohort [58.7% vs. 62.3%; hazard ratio (HR) 0.86, 95% confidence interval (CI) 0.76-0.98], and among patients transported for pPCI (58.7% vs. 64.1%; HR 0.82, 95% CI 0.71-0.96). No difference in all-cause mortality was found, but cardiac mortality was reduced by an absolute of 4.4% in favour of pPCI (18.3% vs. 22.7%; HR 0.78, 95% CI 0.63-0.98). pPCI postponed a main event with 12.3 months in average compared to fibrinolysis (95% CI 5.0-19.5). Conclusion The benefit of pPCI over fibrinolysis was maintained at 16-year follow-up. pPCI reduced the composite endpoint of death or rehospitalization for MI, reduced cardiac mortality, and delayed average time to a main event by approximately 1 year.

Published
2020

13. 16-year follow-up of the Danish Acute Myocardial Infarction 2 (DANAMI-2) trial: primary percutaneous coronary intervention vs. fibrinolysis in ST-segment elevation myocardial infarction

Author

Thrane, Pernille G, primary, Kristensen, Steen D, additional, Olesen, Kevin K W, additional, Mortensen, Leif S, additional, Bøtker, Hans Erik, additional, Thuesen, Leif, additional, Hansen, Henrik S, additional, Abildgaard, Ulrik, additional, Engstrøm, Thomas, additional, Andersen, Henning R, additional, and Maeng, Michael, additional

Published
2019
Full Text
View/download PDF

15. A controlled study of eight months of physical training and reduction of blood pressure in children: the Odense schoolchild study

Author

Hansen, Henrik S., Froberg, Darsten, Hyldebrandt, Niels, and Nielsen, Jens Rokkedal

Subjects
Care and treatment, Physiological aspects, Health aspects, Physical fitness -- Health aspects -- Physiological aspects, Children -- Health aspects -- Physiological aspects, Hypertension -- Care and treatment, Pediatric diseases -- Care and treatment, Blood pressure -- Physiological aspects -- Health aspects, Children -- Diseases -- Health aspects -- Physiological aspects
Abstract

Introduction Regular exercise training generally is being recommended as a health measure for managing hypertension in adulthood. [1 2] A coincident reduction in blood pressure after exercise training in hypertensive [...]

Published
1991

16. Myocardial CT perfusion compared with transthoracic Doppler echocardiography in evaluation of the coronary microvascular function: An iPOWER substudy.

Author

Bechsgaard, Daria F., Hove, Jens D., Michelsen, Marie M., Mygind, Naja D., Pena, Adam, Hansen, Peter R., Hansen, Henrik S., Kastrup, Jens, Høst, Nis, Gustafsson, Ida, and Prescott, Eva

Subjects
DOPPLER echocardiography, CARDIOVASCULAR diseases risk factors, PERFUSION, FLOW velocity, CORONARY disease, CORONARY vasospasm
Abstract

Background: A significant number of women with angina and no obstructive coronary artery disease (CAD; <50% stenosis) have coronary microvascular dysfunction (CMD) which carries an adverse cardiovascular prognosis. Coronary microvascular function can be evaluated by transthoracic Doppler echocardiography (TTDE) as a coronary flow velocity reserve (CFVR) and by static CT myocardial perfusion (CTP) as a myocardial perfusion reserve (MPR). Whether these methods are correlated is not known. We assessed the correlation between CFVR and MPR and investigated whether women with angina, CMD and no obstructive CAD have reduced MPR compared with asymptomatic women. Methods: Static CTP with adenosine‐induced vasodilation and TTDE of the left anterior descending artery with dipyridamole‐induced vasodilation were successfully performed and analysed in 99 women with stable angina and no obstructive CAD and 33 asymptomatic women with no obstructive CAD. CMD was defined as CFVR < 2. Results: Correlation between rate‐pressure product corrected MPR and CFVR was weak but significant (r =.23; p =.007). MPR was highest among asymptomatic women with normal CFVR (median [interquartile range; IQR] 158 [145–181] %). Symptomatic women with normal CFVR had reduced MPR (148 [134–162] %; age‐adjusted p <.001); however, the lowest MPR was found in symptomatic women with CMD (140 [129–164] %; age‐adjusted p <.001), independent of cardiovascular risk factors and haemodynamic parameters (p =.017). Conclusion: Women with angina, CMD and no obstructive CAD had markedly diminished MPR compared with asymptomatic women. Correlation between CFVR and MPR was weak, suggesting that CTP and TTDE are not interchangeable for detection of CMD. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

17. Left Ventricular Structure and Function in Young Elite Cyclists.

Author

Larsen, Søren E., Hansen, Henrik S., Froberg, Karsten, and Nielsen, Jens Rokkedal

Subjects
DIASTOLE (Cardiac cycle), LEFT heart ventricle, CYCLISTS, ECHOCARDIOGRAPHY, HEALTH
Abstract

Examines the association between physical training and changes in the left ventricular structure and function in young elite cyclists. Characteristic of cardiac and left ventricular structure; Use of echocardiography to assess the left ventricular mass after long-term and high intensity training; Validity of transmittal diastolic flow profile in analyzing the diastolic function in early and late velocity.

Published
2000
Full Text
View/download PDF

19. 16-year follow-up of the Danish Acute Myocardial Infarction 2 (DANAMI-2) trial: primary percutaneous coronary intervention vs. fibrinolysis in ST-segment elevation myocardial infarction.

Author

Thrane, Pernille G, Kristensen, Steen D, Olesen, Kevin K W, Mortensen, Leif S, Bøtker, Hans Erik, Thuesen, Leif, Hansen, Henrik S, Abildgaard, Ulrik, Engstrøm, Thomas, Andersen, Henning R, and Maeng, Michael

Abstract

Aims The DANish Acute Myocardial Infarction 2 (DANAMI-2) trial found that interhospital transport to primary percutaneous coronary intervention (pPCI) was superior to fibrinolysis at the local hospital in patients with ST-segment elevation myocardial infarction (STEMI) at 30 days. The present study investigates the 16-year cardiovascular outcomes. Methods and results We randomized 1572 STEMI patients to pPCI or fibrinolysis at 24 referral hospitals and 5 invasive centres in Denmark. Patients randomized to pPCI at referral hospitals were immediately transported to the nearest invasive centre. The main endpoint of the current study was a composite of death or rehospitalization for myocardial infarction (MI). Outcome information beyond 3 years was obtained through Danish health registries. After 16 years, pPCI-treated patients had a sustained lower rate of composite endpoint compared to patients treated with fibrinolysis in the overall cohort [58.7% vs. 62.3%; hazard ratio (HR) 0.86, 95% confidence interval (CI) 0.76–0.98], and among patients transported for pPCI (58.7% vs. 64.1%; HR 0.82, 95% CI 0.71–0.96). No difference in all-cause mortality was found, but cardiac mortality was reduced by an absolute of 4.4% in favour of pPCI (18.3% vs. 22.7%; HR 0.78, 95% CI 0.63–0.98). pPCI postponed a main event with 12.3 months in average compared to fibrinolysis (95% CI 5.0–19.5). Conclusion The benefit of pPCI over fibrinolysis was maintained at 16-year follow-up. pPCI reduced the composite endpoint of death or rehospitalization for MI, reduced cardiac mortality, and delayed average time to a main event by approximately 1 year. Open in new tab Download slide Open in new tab Download slide [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
View/download PDF

20. 10-Year Clinical Outcome After Randomization to Treatment by Sirolimus- or Paclitaxel-Eluting Coronary Stents

Author

Galløe, Anders M., primary, Kelbæk, Henning, additional, Thuesen, Leif, additional, Hansen, Henrik S., additional, Ravkilde, Jan, additional, Hansen, Peter R., additional, Christiansen, Evald H., additional, Abildgaard, Ulrik, additional, Stephansen, Ghita, additional, Lassen, Jens F., additional, Engstrøm, Thomas, additional, Jensen, Jan Skov, additional, Jeppesen, Jørgen L., additional, Bligaard, Niels, additional, Thayssen, Per, additional, Aarøe, Jens, additional, Saunamäki, Kari, additional, Junker, Anders, additional, Tilsted, Hans H., additional, Jensen, Jan S., additional, Bøtker, Hans E., additional, Galatius, Søren, additional, Larsen, Carsten T., additional, Kristensen, Steen D., additional, Krusell, Lars R., additional, Abildstrøm, Steen Z., additional, Meng, Michael, additional, Okkels, Lisette, additional, and Galløe, Anders M., additional

Published
2017
Full Text
View/download PDF

21. Coronary Flow Velocity Reserve Assessed by Transthoracic Doppler:The iPOWER Study: Factors Influencing Feasibility and Quality

Author

Michelsen, Marie M, Peña, Adam, Mygind, Naja D, Frestad, Daria, Gustafsson, Ida, Hansen, Henrik S, Kastrup, Jens, Bech, Jan, Høst, Nis, Prescott, Eva, Michelsen, Marie M, Peña, Adam, Mygind, Naja D, Frestad, Daria, Gustafsson, Ida, Hansen, Henrik S, Kastrup, Jens, Bech, Jan, Høst, Nis, and Prescott, Eva

Abstract

BACKGROUND: Coronary flow velocity reserve (CFVR) measured by transthoracic Doppler echocardiography is a noninvasive measure of microvascular function, but it has not achieved widespread use, mainly because of concerns of validity and feasibility. The aim of this study was to describe the feasibility and factors associated with the quality of CFVR obtained in a large prospective study of women suspected of having microvascular disease.METHODS: Women with angina-like chest pain and no obstructive coronary artery disease on coronary angiography (<50% stenosis) were consecutively examined by transthoracic Doppler echocardiography of the left anterior descending coronary artery to measure CFVR (n = 947). Quality was evaluated on the basis of (1) identification of the left anterior descending coronary artery, (2) maintained probe position throughout the examination, (3) visibility and configuration of the left anterior descending coronary artery in two-dimensional color Doppler mode, and (4) gradual, consistent increases of characteristic, well-defined flow velocity curves in pulsed-wave mode.RESULTS: The mean age (SD) was 62.1 ± 9.7 years. On the basis of the evaluations, patients were divided into four groups according to quality score: nonfeasible (n = 28 [3%]), low quality (n = 80 [8%]), medium quality (n = 451 [48%]), and high quality (n = 388 [41%]). Quality score was associated with diabetes (P < .01), body mass index (P = .02), waist circumference (P = .05), nonsignificant atherosclerosis on coronary angiography (P = .03), and operator experience (P < .01). Low examination quality was associated with lower CFVR (P = .03), also after multivariate adjustment.CONCLUSIONS: Transthoracic Doppler echocardiographic measurement of CFVR is highly feasible and of good quality in experienced hands. However, CFVR is possibly underestimated when examination quality is low. Awareness of pitfalls and potential bias may improve the validity and

Published
2016

24. TCT-45 Optical Coherence Tomography Assessment of Incidence, Morphological Characteristics, and Spontaneous Healing Course of Edge Dissections Following Percutaneous Coronary Intervention with Stent Implantation in Patients with Non-ST segment Elevation Myocardial Infarction

Author

Antonsen, Lisbeth, primary, Thayssen, Per, additional, Hansen, Henrik S., additional, Junker, Anders, additional, Veien, Karsten T., additional, Hansen, Knud N., additional, Hougaard, Mikkel, additional, and Jensen, Lisette Okkels, additional

Published
2015
Full Text
View/download PDF

25. TCT-609 Malapposition, Strut Coverage, and following implantation of the Resolute Integrity Stent in patients with ST Segment elevation myocardial Infarction assessed by Optical Coherence Tomography

Author

Hougaard, Mikkel, primary, Hansen, Henrik S., additional, Thayssen, Per, additional, Maehara, Akiko, additional, Mintz, Gary S., additional, Antonsen, Lisbeth, additional, Junker, Anders, additional, Hansen, Knud N., additional, Veien, Karsten T., additional, Pedersen, Knud Erik, additional, and Jensen, Lisette Okkels, additional

Published
2015
Full Text
View/download PDF

26. TCT-641 Improved Safety and Reduction in Stent Thrombosis After Everolimus-Eluting Stents Versus Sirolimus-Eluting Stents in Patients With Coronary Artery Disease: SORT OUT IV 5-year

Author

Jensen, Lisette Okkels, primary, Thayssen, Per, additional, Christiansen, Evald H., additional, Maeng, Michael, additional, Ravkilde, Jan, additional, Hansen, Knud N., additional, Hansen, Henrik S., additional, Kaltoft, Anne, additional, Krusell, Lars, additional, Tilsted, Hans-Henrik, additional, Junker, Anders, additional, and Lassen, Jens F., additional

Published
2014
Full Text
View/download PDF

28. TCT-394 Optical Coherence Tomography- versus Angiography-guided Percutaneous Coronary Intervention with Biolimus-eluting Stent Implantation in Patients with Myocardial Infarction: Dynamic Malapposition Patterns and Strut Coverage at 6 Months. The OCTACS Trial

Author

Antonsen, Lisbeth, primary, Thayssen, Per, additional, Maehara, Akiko, additional, Hansen, Henrik S., additional, Junker, Anders, additional, Hansen, Knud N., additional, Veien, Karsten T., additional, Hougaard, Mikkel, additional, and Jensen, Lisette Okkels, additional

Published
2014
Full Text
View/download PDF

30. TCT-492 Stent Thrombosis With Ticagrelor Versus Clopidogrel After Percutaneous Coronary Intervention and Ticagrelor or Clopidogrel in Patients With Acute Coronary Syndromes in a Real World Setting

Author

Fallesen, Christian O., primary, Thayssen, Per, additional, Pedersen, Knud Erik, additional, Junker, Anders, additional, Hansen, Knud N., additional, Hansen, Henrik S., additional, Veien, Karsten T., additional, and Jensen, Lisette Okkels, additional

Published
2014
Full Text
View/download PDF

31. Outcomes after revascularisation with everolimus- and sirolimus-eluting stents in patients with acute coronary syndromes and stable angina pectoris: a substudy of the SORT OUT IV trial

Author

Antonsen, Lisbeth, primary, Thayssen, Per, additional, Hansen, Henrik S., additional, Maeng, Michael, additional, Tilsted, Hans-Henrik, additional, Bøtker, Hans E., additional, Ravkilde, Jan, additional, Madsen, Morten, additional, Sørensen, Henrik T., additional, Thuesen, Leif, additional, Lassen, Jens F., additional, and Jensen, Lisette O., additional

Published
2014
Full Text
View/download PDF

39. Severe nodal arrhythmia following direct current cardioversion for atrial flutter.

Author

Hansen, Michael G., Gill, Sabine U. A., Hansen, Henrik S., Hansen, M G, Gill, S U, and Hansen, H S

Subjects
ARRHYTHMIA diagnosis, HYPOTENSION, ELECTRIC countershock, ARRHYTHMIA, ELECTROCARDIOGRAPHY, ATRIAL flutter
Abstract

A case of long-lasting nodal arrhythmia and severe hypotension following DC cardioversion for atrial flutter is presented. The patient, treated with the selective serotonin reuptake inhibitor sertraline and with sotalol, thiopental and digoxin, showed no sign of organic disease or drug intoxication. We suggest that drug interaction in combination with the DC shock and an altered sympaticus/parasympaticus balance during anaesthesia provoked the incident. [ABSTRACT FROM AUTHOR]

Published
1999
Full Text
View/download PDF

40. Dual-therapy CD34 antibody-covered sirolimus-eluting COMBO stents versus sirolimus-eluting Orsiro stents in patients treated with percutaneous coronary intervention: the three-year outcomes of the SORT OUT X randomised clinical trial.

Author

Jakobsen L, Christiansen EH, Freeman P, Kahlert J, Veien K, Maeng M, Raungaard B, Ellert J, Villadsen AB, Kristensen SD, Christensen MK, Terkelsen CJ, Aaroe J, Thim T, Lassen JF, Hougaard M, Eftekhari A, Jensen RV, Støttrup NB, Rasmussen JG, Junker A, Jensen SE, Hansen HS, and Jensen LO

Subjects
Humans, Male, Middle Aged, Female, Aged, Treatment Outcome, Prospective Studies, Coronary Artery Disease therapy, Myocardial Infarction, Drug-Eluting Stents, Percutaneous Coronary Intervention methods, Percutaneous Coronary Intervention adverse effects, Percutaneous Coronary Intervention instrumentation, Sirolimus therapeutic use, Sirolimus administration & dosage, Antigens, CD34 immunology
Abstract

Background: Target lesion failure (TLF) remains an issue with contemporary drug-eluting stents. The dual-therapy sirolimus-eluting and CD34 antibody-coated COMBO stent (DTS) was designed to improve early healing., Aims: We aimed to compare the 3-year outcomes of the DTS and the sirolimus-eluting Orsiro stent (SES) in all-comer patients treated with percutaneous coronary intervention., Methods: The SORT OUT X trial is a prospective multicentre randomised clinical trial with a registry-based follow-up comparing DTS and SES. The primary endpoint, TLF, is a composite of cardiac death, myocardial infarction or target lesion revascularisation (TLR)., Results: A total of 3,146 patients were randomised to treatment with the DTS (1,578 patients) or the SES (1,568 patients). At 3 years, an intention-to-treat analysis showed that 155 patients (9.8%) who were assigned the DTS and 118 patients (7.5%) who were assigned the SES met the primary endpoint (incidence rate ratio for TLF=1.33, 95% confidence interval: 1.04-1.70; p=0.02). This difference was caused by a significantly higher TLF rate in the DTS group compared to the SES group within the first year, which was mainly explained by a higher incidence of TLR in the DTS group compared to the SES group. Of note, the TLF rates were almost identical from 1 year to 3 years in both stent groups., Conclusions: At 3 years, the SES was superior to the DTS, mainly because the DTS was associated with an increased risk of TLF within the first year but not from 1 to 3 years., Clinicaltrials: gov: NCT03216733.

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results