Search

Your search keyword '"Hanratty, C"' showing total 115 results
Start Over Author "Hanratty, C"
115 results on '"Hanratty, C"'

7. Irish cardiac society: Proceedings of annual general meeting held 1st November, 1997

Author

Seifer, C., McNeill, B., O’Donnell, M., Daly, K., Kellett, J., McGee, H. M., Montogomery, A. J., O’Callaghan, D., Horgan, J. H., Mahon, N. G., Codd, M., Brennan, J., Egan, B., McCann, H. A., Sugrue, D. D., Menown, I. B. A., Patterson, R. S. H. W., McMechan, S. R., Hameed, S., Adgey, A. A. J., Baird, S. H., McBride, S. J., Trouton, T. G., Wilson, C., McRedmond, J. P., Fitzgerald, D. J., Crowley, J. J., Tanguay, J-F., Santos, R. M., Stack, R. S., Mahon, N. G., Keelan, P., McCann, H. A., Sugrue, D. D., McKenna, C. J., AuBuchon, R., Camrud, A. R., Holmes, D. R., Schwartz, R. S., McKenna, C. J., Camrud, A. R., Wolff, R., Edwards, W. D., Holmes, D. R., Schwartz, R. S., Hanratty, C., McAuley, D., Young, I., Murtagh, G., O’Keeffe, B., Richardson, G., Scott, M., Chew, E. W., Bailie, N. A., Graham, A. M. J., O’Kane, H., McKenna, C. J., Kwon, H. M., Ellis, L., Holmes, D. R., Virmani, R., Schwartz, R. S., Noelke, L., Wood, A. E., Javadpour, H., Veerasingham, D., Wood, A. E., O’Kane, D., Allen, J. D., Adgey, A. A. J., Hennessy, T., Johnson, P., Hildick-Smith, D., Winter, E., Shapiro, L., McKenna, C. J., Edwards, W. D., Lerman, A., Holmes, D. R., Schwartz, R. S., McGrath, L. T., Passmore, P., Silke, B., McAuley, D., Nugent, A. G., McGurk, C., Hanratty, C., Maguire, S., Johnston, G. D., McAuley, D., Nugent, A. G., McGurk, C., Hanratty, C., Maguire, S., Johnston, G. D., Lovell, S. L., McDowell, G., McEneany, D., Riley, M. S., Nicholls, D. P., Gilligan, D., Sargent, D., Dan, D., Gilligan, D., Elam, G., Rhee, B., Keane, D., Zhou, L., McGovern, B., Garan, H., Ruskin, J., O’Shea, J. C., Tan, H-C., Zidar, J. P., Stack, R. S., Crowley, J. J., O’Keeffe, D. B., Graffin, S., Fitzsimmons, D., Brown, S., Duff, D., Denham, B., Woods, F., Neligan, M., Oslizlok, P., Connolly, C. K., Danton, M. H. D., O’Kane, H., Danton, M., Gladstone, D. J., Craig, B., Mulholland, H. C., Casey, F., Chaudhuri, S., Hinchion, J., Wood, A. E., Hinchion, J., Wood, A. E., Menown, I. B. A., Patterson, R. H. S. W., MacKenzie, G., Adgey, A. A. J., Harbinson, M. T., Burgess, L. M., Moohan, V., McEneaney, D. J., Adgey, A. A. J., Menown, I. B. A., MacKenzie, G., Patterson, R. S. H. W., Adgey, A. A. J., Finnegan, O. C., Doherty, L., Silke, B., Riddell, J. G., Meleady, R., Daly, L., Graham, I., Quinn, M., Foley, B., Lee, J., Mulvihill, N., Crean, P., Walsh, M., O’Morain, C., Quinn, M., Crean, P., Foley, B., Walsh, M., Hynes, C., King, S. M., David, S., Newton, H., Maguire, M., Rafferty, F., Horgan, J. H., Sullivan, P. A., Murphy, D., Gallagher, S., Menown, I. B. A., Allen, J., Anderson, J. McC, Adgey, A. A. J., Dan, D., Hoag, J., Eckberg, D., Gilligan, D., Galvin, J., Garan, H., McGovern, B., Ruskin, J., Mahon, N. G., Diamond, P., Neilan, T., Keelan, E., H. A., McCarthy, C., Sugrue, D. D., Harbinson, M. T., Moohan, V. P., McEneaney, D. J., Burgess, L. M., Anderson, J. McC, Ayers, G. M., Adgey, A. A. J., Roberts, M., Burgess, L., Anderson, C., Wilson, C., Khan, M., Clements, I. P., Miller, W. L., Seifer, C., O’Donnell, M., McNeill, B., Daly, K., Turtle, F., McDowell, G., Long, H., McNair, W., Campbell, N. P. S., Mathew, T. P., Turtle, F., Smye, M., Nesbitt, G. S., Young, I. S., Adgey, A. A. J., Meleady, R., Mulcahy, D., Graham, I. M., Moore, D., Menown, I. B. A., McMechan, S. R., MacKenzie, G., Adgey, A. A. J., Diamond, P., Sugrue, D., Codd, M. B., Galvin, J., Zimmerman, P., Winget, J., Capeless, M., Galvin, J., Garan, H., McGovern, B., Ruskin, J., McKelvey, T. A., Danton, M. H. D., Sarsam, M. I. A., McEneaney, D., Roberts, M., Burgess, L., Anderson, C., Wilson, C., and Khan, M.

Published
1998
Full Text
View/download PDF

9. Guiding Principles for Chronic Total Occlusion Percutaneous Coronary Intervention

Author

Brilakis, ES, Mashayekhi, K, Tsuchikane, E, Abi Rafeh, N, Alaswad, K, Araya, M, Avran, A, Azzalini, L, Babunashvili, AM, Bayani, B, Bhindi, R, Boudou, N, Boukhris, M, Božinović, NŽ, Bryniarski, L, Bufe, A, Buller, CE, Burke, MN, Büttner, HJ, Cardoso, P, Carlino, M, Christiansen, EH, Colombo, A, Croce, K, Damas de Los Santos, F, De Martini, T, Dens, J, Di Mario, C, Dou, K, Egred, M, ElGuindy, AM, Escaned, J, Furkalo, S, Gagnor, A, Galassi, AR, Garbo, R, Ge, J, Goel, PK, Goktekin, O, Grancini, L, Grantham, JA, Hanratty, C, Harb, S, Harding, SA, Henriques, JPS, Hill, JM, Jaffer, FA, Jang, Y, Jussila, R, Kalnins, A, Kalyanasundaram, A, Kandzari, DE, Kao, H-L, Karmpaliotis, D, Kassem, HH, Knaapen, P, Kornowski, R, Krestyaninov, O, Kumar, AVG, Laanmets, P, Lamelas, P, Lee, S-W, Lefevre, T, Li, Y, Lim, S-T, Lo, S, Lombardi, W, McEntegart, M, Munawar, M, Navarro Lecaro, JA, Ngo, HM, Nicholson, W, Olivecrona, GK, Padilla, L, Postu, M, Quadros, A, Quesada, FH, Prakasa Rao, VS, Reifart, N, Saghatelyan, M, Santiago, R, Sianos, G, Smith, E, C Spratt, J, Stone, GW, Strange, JW, Tammam, K, Ungi, I, Vo, M, Vu, VH, Walsh, S, Werner, GS, Wollmuth, JR, Wu, EB, Wyman, RM, Xu, B, Yamane, M, Ybarra, LF, Yeh, RW, Zhang, Q, and Rinfret, S

Subjects
Percutaneous Coronary Intervention, Treatment Outcome, Coronary Occlusion, Chronic Disease, Practice Guidelines as Topic, Collateral Circulation, Humans, Coronary Angiography, Coronary Vessels
Abstract

Outcomes of chronic total occlusion (CTO) percutaneous coronary intervention (PCI) have improved because of advancements in equipment and techniques. With global collaboration and knowledge sharing, we have identified 7 common principles that are widely accepted as best practices for CTO-PCI. 1. Ischemic symptom improvement is the primary indication for CTO-PCI. 2. Dual coronary angiography and in-depth and structured review of the angiogram (and, if available, coronary computed tomography angiography) are key for planning and safely performing CTO-PCI. 3. Use of a microcatheter is essential for optimal guidewire manipulation and exchanges. 4. Antegrade wiring, antegrade dissection and reentry, and the retrograde approach are all complementary and necessary crossing strategies. Antegrade wiring is the most common initial technique, whereas retrograde and antegrade dissection and reentry are often required for more complex CTOs. 5. If the initially selected crossing strategy fails, efficient change to an alternative crossing technique increases the likelihood of eventual PCI success, shortens procedure time, and lowers radiation and contrast use. 6. Specific CTO-PCI expertise and volume and the availability of specialized equipment will increase the likelihood of crossing success and facilitate prevention and management of complications, such as perforation. 7. Meticulous attention to lesion preparation and stenting technique, often requiring intracoronary imaging, is required to ensure optimum stent expansion and minimize the risk of short- and long-term adverse events. These principles have been widely adopted by experienced CTO-PCI operators and centers currently achieving high success and acceptable complication rates. Outcomes are less optimal at less experienced centers, highlighting the need for broader adoption of the aforementioned 7 guiding principles along with the development of additional simple and safe CTO crossing and revascularization strategies through ongoing research, education, and training.

Published
2019

14. Irish cardiac society

Author

Seifer, C., McNeill, B., OʼDonnell, M., Daly, K., Kellett, J., McGee, H. M., Montogomery, A. J., OʼCallaghan, D., Horgan, J. H., Mahon, N. G., Codd, M., Brennan, J., Egan, B., McCann, H. A., Sugrue, D. D., Menown, I. B. A., Patterson, R. S. H. W., McMechan, S. R., Hameed, S., Adgey, A. A. J., Baird, S. H., McBride, S. J., Trouton, T. G., Wilson, C., McRedmond, J. P., Fitzgerald, D. J., Crowley, J. J., Tanguay, J F., Santos, R. M., Stack, R. S., Keelan, P., McKenna, C. J., AuBuchon, R., Camrud, A. R., Holmes, D. R., Schwartz, R. S., Wolff, R., Edwards, W. D., Hanratty, C., McAuley, D., Young, I., Murtagh, G., OʼKeeffe, B., Richardson, G., Scott, M., Chew, E. W., Bailie, N. A., Graham, A. M. J., OʼKane, H., Kwon, H. M., Ellis, L., Virmani, R., Noelke, L., Wood, A. E., Javadpour, H., Veerasingham, D., OʼKane, D., Allen, J. D., Hennessy, T., Johnson, P., Hildick-Smith, D., Winter, E., Shapiro, L., Lerman, A., McGrath, L. T., Passmore, P., Silke, B., Nugent, A. G., McGurk, C., Maguire, S., Johnston, G. D., Lovell, S. L., McDowell, G., McEneany, D., Riley, M. S., Nicholls, D. P., Gilligan, D., Sargent, D., Dan, D., Elam, G., Rhee, B., Keane, D., Zhou, L., McGovern, B., Garan, H., Ruskin, J., OʼShea, J. C., Tan, H C., Zidar, J. P., OʼKeeffe, D. B., Graffin, S., Fitzsimmons, D., Brown, S., Duff, D., Denham, B., Woods, F., Neligan, M., Oslizlok, P., Connolly, C. K., Danton, M. H. D., Danton, M., Gladstone, D. J., Craig, B., Mulholland, H. C., Casey, F., Chaudhuri, S., Hinchion, J., Patterson, R. H. S. W., MacKenzie, G., Harbinson, M. T., Burgess, L. M., Moohan, V., McEneaney, D. J., Finnegan, O. C., Doherty, L., Riddell, J. G., Meleady, R., Daly, L., Graham, I., Quinn, M., Foley, B., Lee, J., Mulvihill, N., Walsh, M., OʼMorain, C., Crean, P., Hynes, C., King, S. M., David, S., Newton, H., Maguire, M., Rafferty, F., Sullivan, P. A., Murphy, D., Gallagher, S., Allen, J., Anderson, McC J., Hoag, J., Eckberg, D., Galvin, J., Diamond, P., Neilan, T., Keelan, E., A., H., McCarthy, C., Moohan, V. P., Ayers, G. M., Roberts, M., Burgess, L., Anderson, C., Khan, M., Clements, I. P., Miller, W. L., Turtle, F., Long, H., McNair, W., Campbell, N. P. S., Mathew, T. P., Smye, M., Nesbitt, G. S., Young, I. S., Mulcahy, D., Graham, I. M., Moore, D., Sugrue, D., Codd, M. B., Zimmerman, P., Winget, J., Capeless, M., McKelvey, T. A., Sarsam, M. I. A., and McEneaney, D.

Published
1998
Full Text
View/download PDF

17. Clinical outcomes of state-of-the-art percutaneous coronary revascularization in patients with de novo three vessel disease: 1-year results of the SYNTAX II study

Author

Escaned, J., Collet, C., Ryan, N., Maria, G.L. De, Walsh, S., Sabate, M., Davies, J., Lesiak, M., Moreno, R., Cruz-Gonzalez, I., Hoole, S.P., West, N., Piek, J.J., Zaman, A., Fath-Ordoubadi, F., Stables, R.H., Appleby, C., Mieghem, N. van, Geuns, R.J.M. van, Uren, N., Zueco, J., Buszman, P., Iniguez, A., Goicolea, J., Hildick-Smith, D., Ochala, A., Dudek, D., Hanratty, C., Cavalcante, R., Kappetein, A.P., Taggart, D.P., Es, G.A. van, Morel, M.A., Vries, T. de, Onuma, Y., Farooq, V., Serruys, P.W., Banning, A.P., Escaned, J., Collet, C., Ryan, N., Maria, G.L. De, Walsh, S., Sabate, M., Davies, J., Lesiak, M., Moreno, R., Cruz-Gonzalez, I., Hoole, S.P., West, N., Piek, J.J., Zaman, A., Fath-Ordoubadi, F., Stables, R.H., Appleby, C., Mieghem, N. van, Geuns, R.J.M. van, Uren, N., Zueco, J., Buszman, P., Iniguez, A., Goicolea, J., Hildick-Smith, D., Ochala, A., Dudek, D., Hanratty, C., Cavalcante, R., Kappetein, A.P., Taggart, D.P., Es, G.A. van, Morel, M.A., Vries, T. de, Onuma, Y., Farooq, V., Serruys, P.W., and Banning, A.P.

Abstract

Contains fulltext : 182263.pdf (Publisher’s version ) (Open Access), Aims: To investigate if recent technical and procedural developments in percutaneous coronary intervention (PCI) significantly influence outcomes in appropriately selected patients with three-vessel (3VD) coronary artery disease. Methods and results: The SYNTAX II study is a multicenter, all-comers, open-label, single arm study that investigated the impact of a contemporary PCI strategy on clinical outcomes in patients with 3VD in 22 centres from four European countries. The SYNTAX-II strategy includes: heart team decision-making utilizing the SYNTAX Score II (a clinical tool combining anatomical and clinical factors), coronary physiology guided revascularisation, implantation of thin strut bioresorbable-polymer drug-eluting stents, intravascular ultrasound (IVUS) guided stent implantation, contemporary chronic total occlusion revascularisation techniques and guideline-directed medical therapy. The rate of major adverse cardiac and cerebrovascular events (MACCE [composite of all-cause death, cerebrovascular event, any myocardial infarction and any revascularisation]) at one year was compared to a predefined PCI cohort from the original SYNTAX-I trial selected on the basis of equipoise 4-year mortality between CABG and PCI. As an exploratory endpoint, comparisons were made with the historical CABG cohort of the original SYNTAX-I trial. Overall 708 patients were screened and discussed within the heart team; 454 patients were deemed appropriate to undergo PCI. At one year, the SYNTAX-II strategy was superior to the equipoise-derived SYNTAX-I PCI cohort (MACCE SYNTAX-II 10.6% vs. SYNTAX-I 17.4%; HR 0.58, 95% CI 0.39-0.85, P = 0.006). This difference was driven by a significant reduction in the incidence of MI (HR 0.27, 95% CI 0.11-0.70, P = 0.007) and revascularisation (HR 0.57, 95% CI 0.37-0.9, P = 0.015). Rates of all-cause death (HR 0.69, 95% CI 0.27-1.73, P = 0.43) and stroke (HR 0.69, 95% CI 0.10-4.89, P = 0.71) were similar. The rate of definite stent thrombosis w

Published
2017

18. Clinical outcomes of state-of-the-art percutaneous coronary revascularization in patients with de novo three vessel disease: 1-year results of the SYNTAX II study

Author

Escaned, J. (Javier), Collet, C. (Carlos), Ryan, N. (Nicola), De Maria, G.L. (Giovanni Luigi), Walsh, S. (Simon), Sabaté, M. (Manel), Davies, J.E. (Justin), Lesiak, M. (MacIej), Moreno, R. (Raúl), Cruz-Gonzalez, I. (Ignacio), Hoole, S.P. (Stephan P.), West, N.E. (Nick), Piek, J.J. (Jan), Zaman, A. (Azfar), Fath-Ordoubadi, F. (Farzin), Stables, R.H. (Rodney), Appleby, C. (Clare), Mieghem, N.M. (Nicolas) van, Geuns, R.J.M. (Robert Jan) van, Uren, N. (Neal), Zueco, J. (Javier), Buszman, P.E. (Pawel), Iiguez, A. (Andres), Goicolea, J. (Javier), Hildick-Smith, D. (David), Ochala, A. (Andrzej), Dudek, D. (Dariusz), Hanratty, C. (Colm), Cavalcante, R. (Rafael), Kappetein, A.P. (Arie Pieter), Taggart, D.P. (David), Es, G.A. (Gerrit Anne) van, Morel, M.-A. (Marie-Angèle), Vries, T. (Ton) de, Onuma, Y. (Yoshinobu), Farooq, V. (Vasim), Serruys, P.W.J.C. (Patrick), Banning, A. (Adrian), Escaned, J. (Javier), Collet, C. (Carlos), Ryan, N. (Nicola), De Maria, G.L. (Giovanni Luigi), Walsh, S. (Simon), Sabaté, M. (Manel), Davies, J.E. (Justin), Lesiak, M. (MacIej), Moreno, R. (Raúl), Cruz-Gonzalez, I. (Ignacio), Hoole, S.P. (Stephan P.), West, N.E. (Nick), Piek, J.J. (Jan), Zaman, A. (Azfar), Fath-Ordoubadi, F. (Farzin), Stables, R.H. (Rodney), Appleby, C. (Clare), Mieghem, N.M. (Nicolas) van, Geuns, R.J.M. (Robert Jan) van, Uren, N. (Neal), Zueco, J. (Javier), Buszman, P.E. (Pawel), Iiguez, A. (Andres), Goicolea, J. (Javier), Hildick-Smith, D. (David), Ochala, A. (Andrzej), Dudek, D. (Dariusz), Hanratty, C. (Colm), Cavalcante, R. (Rafael), Kappetein, A.P. (Arie Pieter), Taggart, D.P. (David), Es, G.A. (Gerrit Anne) van, Morel, M.-A. (Marie-Angèle), Vries, T. (Ton) de, Onuma, Y. (Yoshinobu), Farooq, V. (Vasim), Serruys, P.W.J.C. (Patrick), and Banning, A. (Adrian)

Abstract

Aims: To investigate if recent technical and procedural developments in percutaneous coronary intervention (PCI) significantly influence outcomes in appropriately selected patients with three-vessel (3VD) coronary artery disease. Methods and results: The SYNTAX II study is a multicenter, all-comers, open-label, single arm study that investigated the impact of a contemporary PCI strategy on clinical outcomes in patients with 3VD in 22 centres from four European countries. The SYNTAX-II strategy includes: heart team decision-making utilizing the SYNTAX Score II (a clinical tool combining anatomical and clinical factors), coronary physiology guided revascularisation, implantation of thin strut bio-resorbable-polymer drug-eluting stents, intravascular ultrasound (IVUS) guided stent implantation, contemporary chronic total occlusion revascularisation techniques and guideline-directed medical therapy. The rate of major adverse cardiac and cerebrovascular events (MACCE [composite of all-cause death, cerebrovascular event, any myocardial infarction and any revascularisation]) at one year was compared to a predefined PCI cohort from the original SYNTAX-I trial selected on the basis of equipoise 4-year mortality between CABG and PCI. As an exploratory endpoint, comparisons were made with the historical CABG cohort of the original SYNTAX-I trial. Overall 708 patients were screened and discussed within the heart team; 454 patients were deemed appropriate to undergo PCI. At one year, the SYNTAX-II strategy was superior to the equipoise-derived SYNTAX-I PCI cohort (MACCE SYNTAX-II 10.6% vs. SYNTAX-I 17.4%; HR 0.58, 95% CI 0.39-0.85, P= 0.006). This difference was driven by a significant reduction in the incidence of MI (HR 0.27, 95% CI 0.11-0.70, P= 0.007) and revascularisation (HR 0.57, 95% CI 0.37-0.9, P = 0.015). Rates of all-cause death (HR 0.69, 95% CI 0.27-1.73, P = 0.43) and stroke (HR 0.69, 95% CI 0.10-4.89, P = 0.71) were similar. The rate of definite stent thrombosis wa

Published
2017
Full Text
View/download PDF

19. Clinical outcomes of state-of-the-art percutaneous coronary revascularization in patients with de novo three vessel disease: 1-year results of the SYNTAX II study

Author

Escaned, J, Collet, C, Ryan, N, De Maria, GL, Walsh, S, Sabate, M, Davies, J, Lesiak, M, Moreno, R, Cruz-Gonzalez, I, Hoole, SP, West, NE, Piek, JJ, Zaman, A, Fath-ordoubadi, F, Stables, RH, Appleby, C, van Mieghem, Nicolas, van Geuns, Robert Jan, Uren, N, Zueco, J, Buszman, P, Iniguez, A, Goicolea, J, Hildick-Smith, D, Ochala, A, Dudek, D, Hanratty, C, Cavalcante e Silva, Rafael, Kappetein, Arie-Pieter, Taggart, DP, Es, Gerrit-anne, Morel, Marie-Angele, de Vries, T (Ton), Onuma, Yoshinobu, Farooq, V, Serruys, PWJC (Patrick), Banning, AP, Escaned, J, Collet, C, Ryan, N, De Maria, GL, Walsh, S, Sabate, M, Davies, J, Lesiak, M, Moreno, R, Cruz-Gonzalez, I, Hoole, SP, West, NE, Piek, JJ, Zaman, A, Fath-ordoubadi, F, Stables, RH, Appleby, C, van Mieghem, Nicolas, van Geuns, Robert Jan, Uren, N, Zueco, J, Buszman, P, Iniguez, A, Goicolea, J, Hildick-Smith, D, Ochala, A, Dudek, D, Hanratty, C, Cavalcante e Silva, Rafael, Kappetein, Arie-Pieter, Taggart, DP, Es, Gerrit-anne, Morel, Marie-Angele, de Vries, T (Ton), Onuma, Yoshinobu, Farooq, V, Serruys, PWJC (Patrick), and Banning, AP

Published
2017

22. Hybrid approach improves success of chronic total occlusion angioplasty

Author

Wilson, W M, primary, Walsh, S J, additional, Yan, A T, additional, Hanratty, C G, additional, Bagnall, A J, additional, Egred, M, additional, Smith, E, additional, Oldroyd, K G, additional, McEntegart, M, additional, Irving, J, additional, Strange, J, additional, Douglas, H, additional, and Spratt, J C, additional

Published
2016
Full Text
View/download PDF

26. Impact of proctoring on success rates for percutaneous revascularisation of coronary chronic total occlusions

Author

Sharma, Vinoda, primary, Jadhav, S T, additional, Harcombe, A A, additional, Kelly, P A, additional, Mozid, A, additional, Bagnall, A, additional, Richardson, J, additional, Egred, M, additional, McEntegart, M, additional, Shaukat, A, additional, Oldroyd, K, additional, Vishwanathan, G, additional, Rana, O, additional, Talwar, S, additional, McPherson, M, additional, Strange, J W, additional, Hanratty, C G, additional, Walsh, S J, additional, Spratt, J C, additional, and Smith, W H T, additional

Published
2015
Full Text
View/download PDF

27. 30-day Outcomes From The UK Hybrid CTO Registry

Author

Wilson, W., primary, Walsh, S., additional, Hanratty, C., additional, Douglas, H., additional, McEntegart, M., additional, Oldroyd, K., additional, Bagnall, A., additional, Egred, M., additional, Irving, J., additional, Smith, E., additional, Strange, J., additional, and Spratt, J., additional

Published
2015
Full Text
View/download PDF

28. Design and performance of magneto-optic enhanced Co/Pt-based trilayers having zero Kerr ellipticity.

Author

Atkinson, R., Grundy, P. J., Hanratty, C. M., Pollard, R. J., and Salter, I. W.

Subjects
MAGNETOOPTICS, ELECTROOPTICS, KERR electro-optical effect
Abstract

Presents information on a study that outlined the design philosophy and objectives for producing phase-optimized trilayer structures for magneto-optic enhancement of the polar Kerr effect. Experimental procedure; Theoretical results; Conclusion.

Published
1994
Full Text
View/download PDF

29. Variation in left atrial anatomy in a Northern Irish population: a 64 multi-detector CT study

Author

McHenry, CM, Atkinson, AB, Hunter, SJ, Browne, J, Ennis, CN, Henry, J, Sheridan, B, Bell, PM, Cole, BRW, Purvis, JA, Hughes, SM, Morgan, DR, Donaghy, AE, McCrory, RFR, Walker, S, Convery, RP, Hall, PSJ, Taylor, M, Johnston, SD, Wazir, TU, Cairns, AP, Lewis, G, McQuillan, SL, Adgey, CH, Carl, I, Bhat, S, Lakhanpal, A, Lynch, P, Varghese, A, Scott, PJ, Smith, B, Manoharan, G, Johnson, PW, Neill, J, Douglas, H, Richardson, G, Chew, E, Walsh, S, Hanratty, C, Herity, N, Howe, AJ, Graham, UM, Ritchie, CM, McCance, DR, Donnelly, Deirdre E, McConnell, Vivienne PM, Leslie, H, Young, IS, Mullan, KR, Hunter, M, Hedderwick, S, Donnelly, C, Lewis, AS, McCourt, HJ, Boreham, CA, Courtney, CH, McKinley, MC, Murray, LJ, Woodside, JV, McKavanagh, P, Smyth, AI, Donnelly, PM, Hunter, HL, Corbett, JR, Fearon, P, Kinnaird, M, MacNair, S, Fullerton, K, and Wiggam, MI

Subjects
The Ulster Society of Internal Medicine: 82nd -84th meetings, 2009-2010, familial, three-generation, phenotypic variation, Sotos syndrome, Abstract
Abstract

Throughout the Northern Trust, two different thrombolytic agents, either reteplase or tenecteplase, are used as part of the treatment of acute ST elevation myocardial infarction. Having found no other comparative studies, this retrospective study was designed to compare the efficacy of the two drugs using rate of follow-on emergency angioplasty as the primary outcome. The study retrospectively recruited 40 patients who had received reteplase and 40 who had received tenecteplase. Of the patients who received reteplase, 5 required emergency angiography. Of those who received tenecteplase, 15 required further intervention. This was a significant difference with a ratio of 37.5%:12.5% (p=0.01; significance was assumed to be p, Sotos syndrome is a relatively common overgrowth disorder, following autosomal dominant inheritance, caused by mutations and deletions in the nuclear receptor Set domain containing protein-1, NSD1 gene. Affected individuals generally have advanced bone age, macrocephaly, characteristic facial gestalt and learning difficulties. Other features include scoliosis, seizures, cardiac defects and genitourinary anomalies. Tumours are a rare occurrence. Genotype-phenotype correlations are unclear, though those with a deletion appear to have more severe mental retardation. Full penetrance is seen, although familial Sotos syndrome is extremely rare. The low vertical transmission rate, which is not fully explained by cognitive impairment, is of great importance, particularly for mildly affected patients. Here we report a 3-generation pedigree with 7 affected individuals shown to harbour the NSD1 missense mutation c. 6115C>T. To our knowledge this is the largest Sotos family to be reported. The phenotype is extremely variable, thus highlighting the clinical heterogeneity that may occur. Detailed study of individuals with NSD1 gene abnormalities will be invaluable for further clarification of the phenotype and may lead to NSD1 gene analysis having prognostic value. Long-term follow up of these rare cases of familial Sotos syndrome should make an important contribution to the clarification of these uncertainties.

Published
2011

32. Anomalies of cardiac venous drainage associated with abnormalities of cardiac conduction system.

Author

Morgan, D. R., Hanratty, C. G., Dixon, L. J., Trimble, M., and O'Keeffe, D. B.

Abstract

The embryological development of the superior vena cava (SVC) is complex. If the left common cardinal vein fails to occlude it can, along with the left duct of Cuvier form a left SVC, which frequently drains into the coronary sinus. This may result in abnormalities in the anatomy of this structure. A persistent left SVC occurs in 0·5% of the normal population, and 3% to 4·3% of patients with congenital heart anomalies.The pacemaking tissue of the heart is derived from two sites near the progenitors of the superior vena cava. The right-sided site forms the sinoatrial node, the left-sided site is normally carried down to an area near the coronary sinus.Out of 300 patients with cardiac rhythm abnormalities, who have undergone electrophysiological studies (EPS), or permanent pacemaker insertion (PPI), we identified 12 patients with cardiac conduction abnormalities and anomalies of venous drainage. Anomalies of the coronary sinus may be associated with abnormalities of the conduction system of the heart. This may be due to the close proximity of the coronary sinus to the final position of the left-sided primitive pacemaking tissue. In our series of 300 patients, 4% had an associated left SVC, a similar incidence to that found in previous studies of congenital heart disease. [ABSTRACT FROM PUBLISHER]

Published
2002
Full Text
View/download PDF

38. The effect on endothelial function of vitamin C during methionine induced hyperhomocysteinaemia.

Author

Hanratty, Colm G., McGrath, Lawrence T., McAuley, Daniel F., Young, Ian S., Johnston, Dennis G., Hanratty, C G, McGrath, L T, McAuley, D F, Young, I S, and Johnston, D G

Subjects
VITAMIN C, METHIONINE, HOMOCYSTEINE, VASOMOTOR system, OXIDATIVE stress, ENDOTHELIUM physiology, ACETYLCHOLINE, BLOOD circulation, VASODILATION, CLINICAL trials, COMPARATIVE studies, CROSSOVER trials, ENDOTHELIUM, FOREARM, INTRA-arterial injections, RESEARCH methodology, MEDICAL cooperation, ORAL drug administration, PHARMACOKINETICS, PLETHYSMOGRAPHY, RESEARCH, EVALUATION research, RANDOMIZED controlled trials, BLIND experiment, HYPERHOMOCYSTEINEMIA, DISEASE complications
Abstract

Background: Manipulation of total homocysteine concentration with oral methionine is associated with impairment of endothelial-dependent vasodilation. This may be caused by increased oxidative stress. Vitamin C is an aqueous phase antioxidant vitamin and free radical scavenger. We hypothesised that if the impairment of endothelial function related to experimental hyperhomocysteinaemia was free radically mediated then co-administration of vitamin C should prevent this.Methods: Ten healthy adults took part in this crossover study. Endothelial function was determined by measuring forearm blood flow (FBF) in response to intra-arterial infusion of acetylcholine (endothelial-dependent) and sodium nitroprusside (endothelial-independent). Subjects received methionine (100 mg/Kg) plus placebo tablets, methionine plus vitamin C (2 g orally) or placebo drink plus placebo tablets. Study drugs were administered at 9 am on each study date, a minimum of two weeks passed between each study. Homocysteine (tHcy) concentration was determined at baseline and after 4 hours. Endothelial function was determined at 4 hours. Responses to the vasoactive substances are expressed as the area under the curve of change in FBF from baseline. Data are mean plus 95% Confidence Intervals.Results: Following oral methionine tHcy concentration increased significantly versus placebo. At this time endothelial-dependent responses were significantly reduced compared to placebo (31.2 units [22.1-40.3] vs. 46.4 units [42.0-50.8], p < 0.05 vs. Placebo). Endothelial-independent responses were unchanged. Co-administration of vitamin C did not alter the increase in homocysteine or prevent the impairment of endothelial-dependent responses (31.4 [19.5-43.3] vs. 46.4 units [42.0-50.8], p < 0.05 vs. Placebo)Conclusions: This study demonstrates that methionine increased tHcy with impairment of the endothelial-dependent vasomotor responses. Administration of vitamin C did not prevent this impairment and our results do not support the hypothesis that the endothelial impairment is mediated by adverse oxidative stress. [ABSTRACT FROM AUTHOR]

Published
2001
Full Text
View/download PDF

39. Global Chronic Total Occlusion Crossing Algorithm: JACC State-of-the-Art Review

Author

Wu, Eugene B., Brilakis, Emmanouil S., Mashayekhi, Kambis, Tsuchikane, Etsuo, Alaswad, Khaldoon, Araya, Mario, Avran, Alexandre, Azzalini, Lorenzo, Babunashvili, Avtandil M., Bayani, Baktash, Behnes, Michael, Bhindi, Ravinay, Boudou, Nicolas, Boukhris, Marouane, Bozinovic, Nenad Z., Bryniarski, Leszek, Bufe, Alexander, Buller, Christopher E., Burke, M. Nicholas, Buttner, Achim, Cardoso, Pedro, Carlino, Mauro, Chen, Ji Yan, Christiansen, Evald Hoej, Colombo, Antonio, Croce, Kevin, de los Santos, Felix Damas, de Martini, Tony, Dens, Joseph, di Mario, Carlo, Dou, Kefei, Egred, Mohaned, Elbarouni, Basem, ElGuindy, Ahmed M., Escaned, Javier, Furkalo, Sergey, Gagnor, Andrea, Galassi, Alfredo R., Garbo, Roberto, Gasparini, Gabriele, Ge, Junbo, Ge, Lei, Goel, Pravin Kumar, Goktekin, Omer, Gonzalo, Nieves, Grancini, Luca, Hall, Allison, Hanna Quesada, Franklin Leonardo, Hanratty, Colm, Harb, Stefan, Harding, Scott A., Hatem, Raja, Henriques, Jose P.S., Hildick-Smith, David, Hill, Jonathan M., Hoye, Angela, Jaber, Wissam, Jaffer, Farouc A., Jang, Yangsoo, Jussila, Risto, Kalnins, Artis, Kalyanasundaram, Arun, Kandzari, David E., Kao, Hsien Li, Karmpaliotis, Dimitri, Kassem, Hussien Heshmat, Khatri, Jaikirshan, Knaapen, Paul, Kornowski, Ran, Krestyaninov, Oleg, Kumar, A. V.Ganesh, Lamelas, Pablo Manuel, Lee, Seung Whan, Lefevre, Thierry, Leung, Raymond, Li, Yu, Li, Yue, Lim, Soo Teik, Lo, Sidney, Lombardi, William, Maran, Anbukarasi, McEntegart, Margaret, Moses, Jeffrey, Munawar, Muhammad, Navarro, Andres, Ngo, Hung M., Nicholson, William, Oksnes, Anja, Olivecrona, Goran K., Padilla, Lucio, Patel, Mitul, Pershad, Ashish, Postu, Marin, Qian, Jie, Quadros, Alexandre, Rafeh, Nidal Abi, Råmunddal, Truls, Prakasa Rao, Vithala Surya, Reifart, Nicolaus, Riley, Robert F., Rinfret, Stephane, Saghatelyan, Meruzhan, Sianos, George, Smith, Elliot, Spaedy, Anthony, Spratt, James, Stone, Gregg, Strange, Julian W., Tammam, Khalid O., Thompson, Craig A., Toma, Aurel, Tremmel, Jennifer A., Trinidad, Ricardo Santiago, Ungi, Imre, Vo, Minh, Vu, Vu Hoang, Walsh, Simon, Werner, Gerald, Wojcik, Jaroslaw, Wollmuth, Jason, Xu, Bo, Yamane, Masahisa, Ybarra, Luiz F., Yeh, Robert W., Zhang, Qi, Wu E.B., Brilakis E.S., Mashayekhi K., Tsuchikane E., Alaswad K., Araya M., Avran A., Azzalini L., Babunashvili A.M., Bayani B., Behnes M., Bhindi R., Boudou N., Boukhris M., Bozinovic N.Z., Bryniarski L., Bufe A., Buller C.E., Burke M.N., Buttner A., Cardoso P., Carlino M., Chen J.-Y., Christiansen E.H., Colombo A., Croce K., de los Santos F.D., de Martini T., Dens J., di Mario C., Dou K., Egred M., Elbarouni B., ElGuindy A.M., Escaned J., Furkalo S., Gagnor A., Galassi A.R., Garbo R., Gasparini G., Ge J., Ge L., Goel P.K., Goktekin O., Gonzalo N., Grancini L., Hall A., Hanna Quesada F.L., Hanratty C., Harb S., Harding S.A., Hatem R., Henriques J.P.S., Hildick-Smith D., Hill J.M., Hoye A., Jaber W., Jaffer F.A., Jang Y., Jussila R., Kalnins A., Kalyanasundaram A., Kandzari D.E., Kao H.-L., Karmpaliotis D., Kassem H.H., Khatri J., Knaapen P., Kornowski R., Krestyaninov O., Kumar A.V.G., Lamelas P.M., Lee S.-W., Lefevre T., Leung R., Li Y., Lim S.-T., Lo S., Lombardi W., Maran A., McEntegart M., Moses J., Munawar M., Navarro A., Ngo H.M., Nicholson W., Oksnes A., Olivecrona G.K., Padilla L., Patel M., Pershad A., Postu M., Qian J., Quadros A., Rafeh N.A., Ramunddal T., Prakasa Rao V.S., Reifart N., Riley R.F., Rinfret S., Saghatelyan M., Sianos G., Smith E., Spaedy A., Spratt J., Stone G., Strange J.W., Tammam K.O., Thompson C.A., Toma A., Tremmel J.A., Trinidad R.S., Ungi I., Vo M., Vu V.H., Walsh S., Werner G., Wojcik J., Wollmuth J., Xu B., Yamane M., Ybarra L.F., Yeh R.W., Zhang Q., and Repositório da Universidade de Lisboa

Subjects
Coronary Occlusion, percutaneous coronary intervention, Humans, treatment algorithm, global, Coronary Angiography, chronic total occlusion, Algorithms
Abstract

© 2021 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an open access article under the CC-BY-NC-ND license., The authors developed a global chronic total occlusion crossing algorithm following 10 steps: 1) dual angiography; 2) careful angiographic review focusing on proximal cap morphology, occlusion segment, distal vessel quality, and collateral circulation; 3) approaching proximal cap ambiguity using intravascular ultrasound, retrograde, and move-the-cap techniques; 4) approaching poor distal vessel quality using the retrograde approach and bifurcation at the distal cap by use of a dual-lumen catheter and intravascular ultrasound; 5) feasibility of retrograde crossing through grafts and septal and epicardial collateral vessels; 6) antegrade wiring strategies; 7) retrograde approach; 8) changing strategy when failing to achieve progress; 9) considering performing an investment procedure if crossing attempts fail; and 10) stopping when reaching high radiation or contrast dose or in case of long procedural time, occurrence of a serious complication, operator and patient fatigue, or lack of expertise or equipment. This algorithm can improve outcomes and expand discussion, research, and collaboration.

Published
2021
Full Text
View/download PDF

40. Guiding Principles for Chronic Total Occlusion Percutaneous Coronary Intervention. A Global Expert Consensus Document

Author

Etsuo Tsuchikane, Christopher E. Buller, Pravin K. Goel, A. V.Ganesh Kumar, Elliot J. Smith, Ricardo Santiago, William Lombardi, Risto Jussila, Leszek Bryniarski, Mauro Carlino, Muhammad Munawar, Thierry Lefèvre, Jonathan Hill, David E. Kandzari, Gregg W. Stone, Dimitri Karmpaliotis, Arun Kalyanasundaram, Ran Kornowski, Yangsoo Jang, Nicolas Boudou, Yue Li, Khaldoon Alaswad, Masahisa Yamane, Mohaned Egred, William J. Nicholson, Jason R Wollmuth, Colm G. Hanratty, Margaret McEntegart, Khalid Tammam, Scott A. Harding, James C. Spratt, Qi Zhang, Peep Laanmets, Hsien Li Kao, Tony De Martini, Julian Strange, Evald Høj Christiansen, Heinz Joachim Büttner, Simon J Walsh, Lorenzo Azzalini, Sidney Lo, Robert W. Yeh, Javier Escaned, Hussien Heshmat Kassem, Stefan Harb, Marouane Boukhris, José A. Navarro Lecaro, Alexandre Avran, Pablo Lamelas, Hung M. Ngo, Ahmed ElGuindy, Baktash Bayani, Antonio Colombo, Omer Goktekin, Gerald S. Werner, Nidal Abi Rafeh, José P.S. Henriques, Joseph Dens, Alexandre Schaan de Quadros, Soo Teik Lim, Carlo Di Mario, Franklin Hanna Quesada, Roberto Garbo, Minh Vo, Bo Xu, Mario Araya, Kefei Dou, George Sianos, Ravinay Bhindi, Emmanouil S. Brilakis, J. Aaron Grantham, Göran K. Olivecrona, Pedro Cardoso, Marin Postu, Oleg Krestyaninov, Avtandil M. Babunashvili, Meruzhan Saghatelyan, Vu Hoang Vu, Nicolaus Reifart, Imre Ungi, R. Michael Wyman, M. Nicholas Burke, Luiz F. Ybarra, Vithala Surya Prakasa Rao, Farouc A. Jaffer, Alexander Bufe, Junbo Ge, Kambis Mashayekhi, Artis Kalnins, Andrea Gagnor, Alfredo R. Galassi, Nenad Božinović, Félix Damas de los Santos, Seung-Whan Lee, Lucio Padilla, Stéphane Rinfret, Paul Knaapen, Kevin Croce, Sergey Furkalo, Eugene B. Wu, Luca Grancini, Brilakis E.S., Mashayekhi K., Tsuchikane E., Abi Rafeh N., Alaswad K., Araya M., Avran A., Azzalini L., Babunashvili A.M., Bayani B., Bhindi R., Boudou N., Boukhris M., Bozinovic N.Z., Bryniarski L., Bufe A., Buller C.E., Burke M.N., Buttner H.J., Cardoso P., Carlino M., Christiansen E.H., Colombo A., Croce K., Damas De Los Santos F., De Martini T., Dens J., DI Mario C., Dou K., Egred M., Elguindy A.M., Escaned J., Furkalo S., Gagnor A., Galassi A.R., Garbo R., Ge J., Goel P.K., Goktekin O., Grancini L., Grantham J.A., Hanratty C., Harb S., Harding S.A., Henriques J.P.S., Hill J.M., Jaffer F.A., Jang Y., Jussila R., Kalnins A., Kalyanasundaram A., Kandzari D.E., Kao H.-L., Karmpaliotis D., Kassem H.H., Knaapen P., Kornowski R., Krestyaninov O., Kumar A.V.G., Laanmets P., Lamelas P., Lee S.-W., Lefevre T., Li Y., Lim S.-T., Lo S., Lombardi W., McEntegart M., Munawar M., Navarro Lecaro J.A., Ngo H.M., Nicholson W., Olivecrona G.K., Padilla L., Postu M., Quadros A., Quesada F.H., Prakasa Rao V.S., Reifart N., Saghatelyan M., Santiago R., Sianos G., Smith E., Spratt J.C., Stone G.W., Strange J.W., Tammam K., Ungi I., Vo M., Vu V.H., Walsh S., Werner G.S., Wollmuth J.R., Wu E.B., Wyman R.M., Xu B., Yamane M., Ybarra L.F., Yeh R.W., Zhang Q., Rinfret S., and Repositório da Universidade de Lisboa

Subjects
medicine.medical_specialty, Guiding Principles, SCORING SYSTEM, medicine.medical_treatment, Perforation (oil well), percutaneous coronary, Revascularization, MULTICENTER CTO REGISTRY, CARDIOVERTER-DEFIBRILLATOR RECIPIENTS, methods, LONG-TERM OUTCOMES, PROCEDURAL OUTCOMES, Physiology (medical), treatment outcome, INTRAVASCULAR ULTRASOUND, medicine, COMPUTED-TOMOGRAPHY, Intensive care medicine, intervention, HEALTH-STATUS, treatment, VENTRICULAR-ARRHYTHMIAS, business.industry, percutaneous coronary intervention, Stent, Percutaneous coronary intervention, Reentry, RETROGRADE APPROACH, coronary occlusion, Coronary occlusion, Conventional PCI, outcome, Cardiology and Cardiovascular Medicine, business
Abstract

© American Heart Association, Inc., Outcomes of chronic total occlusion (CTO) percutaneous coronary intervention (PCI) have improved because of advancements in equipment and techniques. With global collaboration and knowledge sharing, we have identified 7 common principles that are widely accepted as best practices for CTO-PCI. 1. Ischemic symptom improvement is the primary indication for CTO-PCI. 2. Dual coronary angiography and in-depth and structured review of the angiogram (and, if available, coronary computed tomography angiography) are key for planning and safely performing CTO-PCI. 3. Use of a microcatheter is essential for optimal guidewire manipulation and exchanges. 4. Antegrade wiring, antegrade dissection and reentry, and the retrograde approach are all complementary and necessary crossing strategies. Antegrade wiring is the most common initial technique, whereas retrograde and antegrade dissection and reentry are often required for more complex CTOs. 5. If the initially selected crossing strategy fails, efficient change to an alternative crossing technique increases the likelihood of eventual PCI success, shortens procedure time, and lowers radiation and contrast use. 6. Specific CTO-PCI expertise and volume and the availability of specialized equipment will increase the likelihood of crossing success and facilitate prevention and management of complications, such as perforation. 7. Meticulous attention to lesion preparation and stenting technique, often requiring intracoronary imaging, is required to ensure optimum stent expansion and minimize the risk of short- and long-term adverse events. These principles have been widely adopted by experienced CTO-PCI operators and centers currently achieving high success and acceptable complication rates. Outcomes are less optimal at less experienced centers, highlighting the need for broader adoption of the aforementioned 7 guiding principles along with the development of additional simple and safe CTO crossing and revascularization strategies through ongoing research, education, and training.

Published
2019
Full Text
View/download PDF

41. Centrality dependence of the pseudorapidity density distribution for charged particles in Pb-Pb collisions at √sNN = 2.76 TeV

Author

E. Abbas a, B. Abelev bt, J. Adam al, D. Adamová ca, A. M. Adare dz, M. M. Aggarwal ce, G. Aglieri Rinella ah, M. Agnello cv, A. G. Agocs dy, A. Agostinelli ab, Z. Ahammed dt, A. Ahmad Masoodi r, N. Ahmad r, S. U. Ahn bm, S. A. Ahn bm, I. Aimo y, cv, ck, M. Ajaz p, A. Akindinov ay, D. Aleksandrov cq, B. Alessandro cv, A. Alici cx, m, A. Alkin d, E. Almaráz Aviña bi, J. Alme aj, T. Alt an, V. Altini af, S. Altinpinar s, I. Altsybeev dv, C. Andrei bw, A. Andronic cn, V. Anguelov cj, J. Anielski bg, C. Anson t, T. Anticˇic ́ co, F. Antinori cw, P. Antonioli cx, L. Aphecetche dd, H. Appelshäuser be, N. Arbor bp, S. Arcelli ab, A. Arend be, N. Armesto q, R. Arnaldi cv, T. Aronsson dz, I. C. Arsene cn, M. Arslandok be, A. Asryan dv, A. Augustinus ah, R. Averbeck cn, T. C. Awes cb, J. Äystö aq, M. D. Azmi r, M. Bach an, A. Badalà cu, Y. W. Baek bo, R. Bailhache be, R. Bala ch, A. Baldisseri o, F. Baltasar Dos Santos Pedrosa ah, J. Bán az, R. C. Baral ba, R. Barbera aa, F. Barile af, G. G. Barnaföldi dy, L. S. Barnby cs, V. Barret bo, J. Bartke dh, M. Basile ab, N. Bastid bo, S. Basu dt, B. Bathen bg, G. Batigne dd, B. Batyunya bk, P. C. Batzing v, C. Baumann be, I. G. Bearden by, H. Beck be, N. K. Behera as, I. Belikov bj, F. Bellini ab, R. Bellwied dn, E. Belmont Moreno bi, G. Bencedi dy, S. Beole y, I. Berceanu bw, A. Bercuci bw, Y. Berdnikov cc, D. Berenyi dy, A. A. E. Bergognon dd, R. A. Bertens ax, D. Berzano y, L. Betev ah, A. Bhasin ch, A. K. Bhati ce, J. Bhom dr, N. Bianchi bq, L. Bianchi y, C. Bianchin ax, J. Bielcˇík al, J. Bielcˇíková ca, A. Bilandzic by, S. Bjelogrlic ax, F. Blanco k, F. Blanco dn, D. Blau cq, C. Blume be, M. Boccioli ah, S. Böttger bd, A. Bogdanov bu, H. Bøggild by, M. Bogolyubsky av, L. Boldizsár dy, M. Bombara am, J. Book be, H. Borel o, A. Borissov dx, F. Bossú cg, M. Botje bz, E. Botta y, E. Braidot bs, P. Braun Munzinger cn, M. Bregant dd, T. Breitner bd, T. A. Broker be, T. A. Browning cl, M. Broz ak, R. Brun ah, E. Bruna y, G. E. Bruno af, D. Budnikov cp, H. Buesching be, S. Bufalino y, P. Buncic ah, O. Busch cj, Z. Buthelezi cg, D. Caffarri ac, X. Cai h, H. Caines dz, E. Calvo Villar ct, V. Canoa Roman l, G. Cara Romeo cx, F. Carena ah, W. Carena ah, N. Carlin Filho dk, F. Carminati ah, A. Casanova Díaz bq, J. Castillo Castellanos o, J. F. Castillo Hernandez cn, E. A. R. Casula x, V. Catanescu bw, C. Cavicchioli ah, C. Ceballos Sanchez j, J. Cepila al, P. Cerello cv, B. Chang aq, S. Chapeland ah, J. L. Charvet o, S. Chattopadhyay dt, S. Chattopadhyay cr, M. Cherney cd, C. Cheshkov ah, B. Cheynis dm, V. Chibante Barroso ah, D. D. Chinellato dn, P. Chochula ah, M. Chojnacki by, S. Choudhury dt, P. Christakoglou bz, C. H. Christensen by, P. Christiansen ag, T. Chujo dr, S. U. Chung cm, C. Cicalo cy, L. Cifarelli ab, F. Cindolo cx, J. Cleymans cg, F. Colamaria af, D. Colella af, A. Collu x, G. Conesa Balbastre bp, Z. Conesa del Valle ah, M. E. Connors dz, G. Contin w, J. G. Contreras l, T. M. Cormier dx, Y. Corrales Morales y, P. Cortese ae, I. Cortés Maldonado c, M. R. Cosentino bs, F. Costa ah, M. E. Cotallo k, E. Crescio l, P. Crochet bo, E. Cruz Alaniz bi, R. Cruz Albino l, E. Cuautle bh, L. Cunqueiro bq, A. Dainese ac, H. H. Dalsgaard by, R. Dangh, A. Danubc, K. Dascr, I. Dasau, S. Dase, D. Dascr, A. Dashdl, S. Dashas, S. Dedt, G. O. V. de Barros dk, A. De Caro ad, G. de Cataldo da, J. de Cuveland an, A. De Falco x, D. De Gruttola ad, H. Delagrange dd, A. Deloff bv, N. De Marco cv, E. Dénes dy, S. De Pasquale ad, A. Deppman dk, G. D. Erasmo af, R. de Rooij ax, M. A. Diaz Corchero k, D. Di Bari af, T. Dietel bg, C. Di Giglio af, S. Di Liberto db, A. Di Mauro ah, P. Di Nezza bq, R. Divià ah, Ø. Djuvsland s, A. Dobrin dx, ag, ax, T. Dobrowolski bv, B. Dönigus cn, O. Dordic v, O. Driga dd, A. K. Dubey dt, A. Dubla ax, L. Ducroux dm, P. Dupieux bo, A. K. Dutta Majumdar cr, D. Elia da, D. Emschermann bg, H. Engel bd, B. Erazmus ah, H. A. Erdal aj, D. Eschweiler an, B. Espagnon au, M. Estienne dd, S. Esumi dr, D. Evans cs, S. Evdokimov av, G. Eyyubova v, D. Fabris ac, J. Faivre bp, D. Falchieri ab, A. Fantoni bq, M. Fasel cj, D. Fehlker s, L. Feldkamp bg, D. Felea bc, A. Feliciello cv, B. Fenton Olsen bs, G. Feofilov dv, A. Fernández Téllez c, A. Ferretti y, A. Festanti ac, J. Figiel dh, M. A. S. Figueredo dk, S. Filchagin cp, D. Finogeev aw, F. M. Fionda af, E. M. Fiore af, E. Floratos cf, M. Floris ah, S. Foertsch cg, P. Foka cn, S. Fokin cq, A. Francescon ah, U. Frankenfeld cn, U. Fuchs ah, C. Furget bp, M. Fusco Girard ad, J. J. Gaardhøje by, M. Gagliardi y, A. Gago ct, M. Gallio y, D. R. Gangadharan t, P. Ganoti cb, C. Garabatos cn, E. Garcia Solis n, C. Gargiulo ah, I. Garishvili bt, J. Gerhard an, M. Germain dd, C. Geuna o, A. Gheata ah, M. Gheata bc, B. Ghidini af, P. Ghosh dt, P. Gianotti bq, M. R. Girard dw, P. Giubellino ah, E. Gladysz Dziadus dh, P. Glässel cj, R. Gomez dj, l, E. G. Ferreiro q, L. H. González Trueba bi, P. González Zamora k, S. Gorbunov an, A. Goswami ci, S. Gotovac df, L. K. Graczykowski dw, R. Grajcarek cj, A. Grelli ax, A. Grigoras ah, C. Grigoras ah, V. Grigoriev bu, A. Grigoryan b, S. Grigoryan bk, B. Grinyov d, N. Grion cz, P. Gros ag, J. F. Grosse Oetringhaus ah, J. Y. Grossiord dm, R. Grosso ah, F. Guber aw, R. Guernane bp, B. Guerzoni ab, M. Guilbaud dm, K. Gulbrandsen by, H. Gulkanyan b, T. Gunji dq, R. Gupta ch, A. Gupta ch, R. Haake bg, Ø. Haaland s, C. Hadjidakis au, M. Haiduc bc, H. Hamagaki dq, G. Hamar dy, B. H. Han u, L. D. Hanratty cs, A. Hansen by, Z. Harmanová Tóthová am, J. W. Harris dz, M. Hartig be, A. Harton n, D. Hatzifotiadou cx, S. Hayashi dq, A. Hayrapetyan ah, b, S. T. Heckel be, M. Heide bg, H. Helstrup aj, A. Herghelegiu bw, G. Herrera Corral l, N. Herrmann cj, B. A. Hess ds, K. F. Hetland aj, B. Hicks dz, B. Hippolyte bj, Y. Hori dq, P. Hristov ah, I. Hrˇivnácˇová au, M. Huang s, T. J. Humanic t, D. S. Hwang u, R. Ichou bo, R. Ilkaev cp, I. Ilkiv bv, M. Inaba dr, E. Incani x, P. G. Innocenti ah, G. M. Innocenti y, M. Ippolitov cq, M. Irfan r, C. Ivan cn, V. Ivanov cc, A. Ivanov dv, M. Ivanov cn, O. Ivanytskyi d, A. Jachołkowski aa, P. M. Jacobs bs, C. Jahnke dk, H. J. Jang bm, M. A. Janik dw, P. H. S. Y. Jayarathna dn, S. Jena as, D. M. Jha dx, R. T. Jimenez Bustamante bh, P. G. Jones cs, H. Jung ao, A. Jusko cs, A. B. Kaidalov ay, S. Kalcher an, P. Kalinˇák az, T. Kalliokoski aq, A. Kalweit ah, J. H. Kang eb, V. Kaplin bu, S. Kar dt, A. Karasu Uysal ah, ea, bn, O. Karavichev aw, T. Karavicheva aw, E. Karpechev aw, A. Kazantsev cq, U. Kebschull bd, R. Keidel ec, B. Ketzer be, K. H. Khan p, M. M. Khan r, P. Khan cr, S. A. Khan dt, A. Khanzadeev cc, Y. Kharlov av, B. Kileng aj, M. Kim eb, S. Kim u, B. Kim eb, T. Kim eb, D. J. Kim aq, D. W. Kim ao, J. H. Kim u, J. S. Kim ao, M. Kim ao, S. Kirsch an, I. Kisel an, S. Kiselev ay, A. Kisiel dw, J. L. Klay g, J. Klein cj, C. Klein Bösing bg, M. Kliemant be, A. Kluge ah, M. L. Knichel cn, A. G. Knospe di, M. K. Köhler cn, T. Kollegger an, A. Kolojvari dv, M. Kompaniets dv, V. Kondratiev dv, N. Kondratyeva bu, A. Konevskikh aw, V. Kovalenko dv, M. Kowalski dh, S. Kox bp, G. Koyithatta Meethaleveedu as, J. Kral aq, I. Králik az, F. Kramer be, A. Kravcˇáková am, M. Krelina al, M. Kretz an, M. Krivda cs, F. Krizek aq, M. Krus al, E. Kryshen cc, M. Krzewicki cn, V. Kucera ca, Y. Kucheriaev cq, T. Kugathasan ah, C. Kuhn bj, P. G. Kuijer bz, I. Kulakov be, J. Kumar as, P. Kurashvili bv, A. Kurepin aw, A. B. Kurepin aw, A. Kuryakin cp, S. Kushpil ca, V. Kushpil ca, H. Kvaerno v, M. J. Kweon cj, Y. Kwon eb, P. Ladrón de Guevara bh, I. Lakomov au, R. Langoy s, S. L. La Pointe ax, C. Lara bd, A. Lardeux dd, P. La Rocca aa, M. Lechman ah, S. C. Lee ao, G. R. Lee cs, I. Legrand ah, J. Lehnert be, R. C. Lemmon dc, M. Lenhardt cn, V. Lenti da, H. León bi, M. Leoncino y, I. León Monzón dj, P. Lévai dy, S. Li bo, h, J. Lien s, R. Lietava cs, S. Lindal v, V. Lindenstruth an, C. Lippmann cn, M. A. Lisa t, H. M. Ljunggren ag, D. F. Lodato ax, P. I. Loenne s, V. R. Loggins dx, V. Loginov bu, D. Lohner cj, C. Loizides bs, K. K. Loo aq, X. Lopez bo, E. López Torres j, G. Løvhøiden v, X. G. Lu cj, P. Luettig be, M. Lunardon ac, J. Luo h, C. Luzzi ah, K. Ma h, R. Ma dz, D. M. Madagodahettige Don dn, A. Maevskaya aw, M. Mager bf, D. P. Mahapatra ba, A. Maire cj, M. Malaev cc, I. Maldonado Cervantes bh, Ludmila Malinina bk, 1, D. Mal’Kevich ay, P. Malzacher cn, A. Mamonov cp, L. Manceau cv, L. Mangotra ch, V. Manko cq, F. Manso bo, V. Manzari da, Y. Mao h, M. Marchisone bo, y, J. Mareš bb, A. Margotti cx, A. Marín cn, C. Markert di, M. Marquard be, I. Martashvili dp, N. A. Martin cn, P. Martinengo ah, M. I. Martínez c, G. Martínez García dd, Y. Martynov d, A. Mas dd, S. Masciocchi cn, M. Masera y, A. Masoni cy, L. Massacrier dd, A. Mastroserio af, A. Matyja dh, C. Mayer dh, J. Mazer dp, M. A. Mazzoni db, F. Meddi z, A. Menchaca Rocha bi, J. Mercado Pérez cj, M. Meres ak, Y. Miake dr, K. Mikhaylov bk, L. Milano ah, Jovan Milosevic v, 2, A. Mischke ax, A. N. Mishra ci, D. Mis ́kowiec cn, C. Mitu bc, S. Mizuno dr, J. Mlynarz dx, B. Mohanty dt, L. Molnar dy, L. Montaño Zetina l, M. Monteno cv, E. Montes k, T. Moon eb, M. Morando ac, D. A. Moreira De Godoy dk, S. Moretto ac, A. Morreale aq, A. Morsch ah, V. Muccifora bq, E. Mudnic df, S. Muhuri dt, M. Mukherjee dt, H. Müller ah, M. G. Munhoz dk, S. Murray cg, L. Musa ah, J. Musinsky az, B. K. Nandi as, R. Nania cx, E. Nappi da, C. Nattrass dp, T. K. Nayak dt, S. Nazarenko cp, A. Nedosekin ay, M. Nicassio af, M. Niculescu bc, B. S. Nielsen by, T. Niida dr, S. Nikolaev cq, V. Nikolic co, S. Nikulin cq, V. Nikulin cc, B. S. Nilsen cd, M. S. Nilsson v, F. Noferini cx, P. Nomokonov bk, G. Nooren ax, A. Nyanin cq, A. Nyatha as, C. Nygaard by, J. Nystrand s, A. Ochirov dv, H. Oeschler bf, ah, cj, S. Oh dz, S. K. Oh ao, J. Oleniacz dw, A. C. Oliveira Da Silva dk, C. Oppedisano cv, A. Ortiz Velasquez ag, A. Oskarsson ag, P. Ostrowski dw, J. Otwinowski cn, K. Oyama cj, K. Ozawa dq, Y. Pachmayer cj, M. Pachr al, F. Padilla y, P. Pagano ad, G. Paic ́ bh, F. Painke an, C. Pajares q, S. K. Pal dt, A. Palaha cs, A. Palmeri cu, V. Papikyan b, G. S. Pappalardo cu, W. J. Park cn, A. Passfeld bg, D. I. Patalakha av, V. Paticchio da, B. Paul cr, A. Pavlinov dx, T. Pawlak dw, T. Peitzmann ax, H. Pereira Da Costa o, E. Pereira De Oliveira Filho dk, D. Peresunko cq, C. E. Pérez Lara bz, D. Perrino af, W. Peryt dw, A. Pesci cx, Y. Pestov f, V. Petrácˇek al, M. Petran al, M. Petris bw, P. Petrov cs, M. Petrovici bw, C. Petta aa, M. Pikna ak, P. Pillot dd, O. Pinazza ah, L. Pinsky dn, N. Pitz be, D. B. Piyarathna dn, M. Planinic co, M. Płoskon ́ bs, J. Pluta dw, T. Pocheptsov bk, S. Pochybova dy, P. L. M. Podesta Lerma dj, M. G. Poghosyan ah, K. Polák bb, B. Polichtchouk av, N. Poljak ax, A. Pop bw, S. Porteboeuf Houssais bo, V. Pospíšil al, B. Potukuchi ch, S. K. Prasad dx, R. Preghenella cx, F. Prino cv, C. A. Pruneau dx, I. Pshenichnov aw, G. Puddu x, V. Punin cp, M. Putiš am, J. Putschke dx, H. Qvigstad v, A. Rachevski cz, A. Rademakers ah, T. S. Räihä aq, J. Rak aq, A. Rakotozafindrabe o, L. Ramello ae, S. Raniwala ci, R. Raniwala ci, S. S. Räsänen aq, B. T. Rascanu be, D. Rathee ce, W. Rauch ah, K. F. Read dp, J. S. Real bp, K. Redlich bv, 3, R. J. Reed dz, A. Rehman s, P. Reichelt be, M. Reicher ax, R. Renfordt be, A. R. Reolon bq, A. Reshetin aw, F. Rettig an, J. P. Revol ah, K. Reygers cj, L. Riccati cv, R. A. Ricci br, T. Richert ag, M. Richter v, P. Riedler ah, W. Riegler ah, F. Riggi aa, M. Rodríguez Cahuantzi c, A. Rodriguez Manso bz, K. Røed s, v, E. Rogochaya bk, D. Rohr an, D. Röhrich s, R. Romita cn, F. Ronchetti bq, P. Rosnet bo, S. Rossegger ah, A. Rossi ah, P. Roy cr, C. Roy bj, A. J. Rubio Montero k, R. Russo y, E. Ryabinkin cq, A. Rybicki dh, S. Sadovsky av, K. Šafarˇík ah, R. Sahoo at, P. K. Sahu ba, J. Saini dt, H. Sakaguchi ar, S. Sakai bs, D. Sakata dr, C. A. Salgado q, J. Salzwedel t, S. Sambyal ch, V. Samsonov cc, X. Sanchez Castro bj, L. Šándor az, A. Sandoval bi, M. Sano dr, G. Santagati aa, R. Santoro ah, J. Sarkamo aq, D. Sarkar dt, E. Scapparone cx, F. Scarlassara ac, R. P. Scharenberg cl, C. Schiaua bw, R. Schicker cj, H. R. Schmidt ds, C. Schmidt cn, S. Schuchmann be, J. Schukraft ah, T. Schuster dz, Y. Schutz ah, K. Schwarz cn, K. Schweda cn, G. Scioli ab, E. Scomparin cv, R. Scott dp, P. A. Scott cs, G. Segato ac, I. Selyuzhenkov cn, S. Senyukov bj, J. Seo cm, S. Serci x, E. Serradilla k, A. Sevcenco bc, A. Shabetai dd, G. Shabratova bk, R. Shahoyan ah, N. Sharma dp, S. Sharma ch, S. Rohni ch, K. Shigaki ar, K. Shtejer j, Y. Sibiriak cq, E. Sicking bg, S. Siddhanta cy, T. Siemiarczuk bv, D. Silvermyr cb, C. Silvestre bp, G. Simatovic bh, G. Simonetti ah, R. Singaraju dt, R. Singh ch, S. Singha dt, V. Singhal dt, B. C. Sinha dt, T. Sinha cr, B. Sitar ak, M. Sitta ae, T. B. Skaali v, K. Skjerdal s, R. Smakal al, N. Smirnov dz, R. J. M. Snellings ax, C. Søgaard ag, R. Soltz bt, M. Song eb, J. Song cm, C. Soos ah, F. Soramel ac, I. Sputowska dh, M. Spyropoulou Stassinaki cf, B. K. Srivastava cl, J. Stachel cj, I. Stan bc, G. Stefanek bv, M. Steinpreis t, E. Stenlund ag, G. Steyn cg, J. H. Stiller cj, D. Stocco dd, M. Stolpovskiy av, P. Strmen ak, A. A. P. Suaide dk, M. A. Subieta Vásquez y, T. Sugitate ar, C. Suire au, R. Sultanov ay, M. Šumbera ca, T. Susa co, T. J. M. Symons bs, A. Szanto de Toledo dk, I. Szarka ak, A. Szczepankiewicz dh, M. Szyman ́ ski dw, J. Takahashi dl, M. A. Tangaro af, J. D. Tapia Takaki au, A. Tarantola Peloni be, A. Tarazona Martinez ah, A. Tauro ah, G. Tejeda Muñoz c, A. Telesca ah, A. Ter Minasyan cq, C. Terrevoli af, J. Thäder cn, D. Thomas ax, R. Tieulent dm, A. R. Timmins dn, D. Tlusty al, A. Toia an, ac, cw, H. Torii dq, L. Toscano cv, V. Trubnikov d, D. Truesdale t, W. H. Trzaska aq, T. Tsuji dq, A. Tumkin cp, R. Turrisi cw, T. S. Tveter v, J. Ulery be, K. Ullaland s, J. Ulrich bl, A. Uras dm, G. M. Urciuoli db, G. L. Usai x, M. Vajzer al, M. Vala bk, L. Valencia Palomo au, P. Vande Vyvre ah, J. W. Van Hoorne ah, M. van Leeuwen ax, L. Vannucci br, A. Vargas c, R. Varma as, M. Vasileiou cf, A. Vasiliev cq, V. Vechernin dv, M. Veldhoen ax, M. Venaruzzo w, E. Vercellin y, S. Vergara c, R. Vernet i, M. Verweij ax, L. Vickovic df, G. Viesti ac, J. Viinikainen aq, Z. Vilakazi cg, O. Villalobos Baillie cs, Y. Vinogradov cp, L. Vinogradov dv, A. Vinogradov cq, T. Virgili ad, Y. P. Viyogi dt, A. Vodopyanov bk, M. A. Völkl cj, S. Voloshin dx, K. Voloshin ay, G. Volpe ah, B. von Haller ah, I. Vorobyev dv, D. Vranic cn, J. Vrláková am, B. Vulpescu bo, A. Vyushin cp, B. Wagner s, V. Wagner al, R. Wan h, Y. Wang h, M. Wang h, Y. Wang cj, K. Watanabe dr, M. Weber dn, J. P. Wessels ah, U. Westerhoff bg, J. Wiechula ds, J. Wikne v, M. Wilde bg, G. Wilk bv, M. C. S. Williams cx, B. Windelband cj, L. Xaplanteris Karampatsos di, C. G. Yaldo dx, Y. Yamaguchi dq, S. Yang s, P. Yang h, H. Yang o, S. Yasnopolskiy cq, J. Yi cm, Z. Yin h, I. K. Yoo cm, J. Yoon eb, W. Yu be, X. Yuan h, I. Yushmanov cq, V. Zaccolo by, C. Zach al, C. Zampolli cx, S. Zaporozhets bk, A. Zarochentsev dv, P. Závada bb, N. Zaviyalov cp, H. Zbroszczyk dw, P. Zelnicek bd, I. S. Zgura bc, M. Zhalov cc, H. Zhang h, X. Zhang bs, bo, h, Y. Zhang h, D. Zhou h, F. Zhou h, Y. Zhou ax, H. Zhu h, J. Zhu h, X. Zhu h, A. Zichichi ab, A. Zimmermann cj, G. Zinovjev d, Y. Zoccarato dm, M. Zynovyev d, M. Zyzak, CAMERINI, Paolo, FRAGIACOMO, ENRICO, LEA, RAMONA, LUPARELLO, GRAZIA, MARGAGLIOTTI, GIACOMO, PIANO, STEFANO, RUI, RINALDO, E., Abbas a, B., Abelev bt, J., Adam al, D., Adamová ca, A. M., Adare dz, M. M., Aggarwal ce, G., Aglieri Rinella ah, M., Agnello cv, Ck, A. G., Agocs dy, A., Agostinelli ab, Z., Ahammed dt, A., Ahmad Masoodi r, N., Ahmad r, S. U., Ahn bm, S. A., Ahn bm, I., Aimo y, Cv, Ck, M., Ajaz p, A., Akindinov ay, D., Aleksandrov cq, B., Alessandro cv, A., Alici cx, M, A., Alkin d, E., Almaráz Aviña bi, J., Alme aj, T., Alt an, V., Altini af, S., Altinpinar, I., Altsybeev dv, C., Andrei bw, A., Andronic cn, V., Anguelov cj, J., Anielski bg, C., Anson t, T., Anticˇic ́ co, F., Antinori cw, P., Antonioli cx, L., Aphecetche dd, H., Appelshäuser be, N., Arbor bp, S., Arcelli ab, A., Arend be, N., Armesto q, R., Arnaldi cv, T., Aronsson dz, I. C., Arsene cn, M., Arslandok be, A., Asryan dv, A., Augustinus ah, R., Averbeck cn, T. C., Awes cb, J., Äystö aq, M. D., Azmi r, Cg, M., Bach an, A., Badalà cu, Y. W., Baek bo, Ao, R., Bailhache be, R., Bala ch, Cv, A., Baldisseri o, F., Baltasar Dos Santos Pedrosa ah, J., Bán az, R. C., Baral ba, R., Barbera aa, F., Barile af, G. G., Barnaföldi dy, L. S., Barnby c, V., Barret bo, J., Bartke dh, M., Basile ab, N., Bastid bo, S., Basu dt, B., Bathen bg, G., Batigne dd, B., Batyunya bk, P. C., Batzing v, C., Baumann be, I. G., Bearden by, H., Beck be, N. K., Behera a, I., Belikov bj, F., Bellini ab, R., Bellwied dn, E., Belmont Moreno bi, G., Bencedi dy, S., Beole y, I., Berceanu bw, A., Bercuci bw, Y., Berdnikov cc, D., Berenyi dy, A. A. E., Bergognon dd, R. A., Bertens ax, D., Berzano y, L., Betev ah, A., Bhasin ch, A. K., Bhati ce, J., Bhom dr, N., Bianchi bq, L., Bianchi y, C., Bianchin ax, J., Bielcˇík al, J., Bielcˇíková ca, A., Bilandzic by, S., Bjelogrlic ax, F., Blanco k, F., Blanco dn, D., Blau cq, C., Blume be, M., Boccioli ah, S., Böttger bd, A., Bogdanov bu, H., Bøggild by, M., Bogolyubsky av, L., Boldizsár dy, M., Bombara am, J., Book be, H., Borel o, A., Borissov dx, F., Bossú cg, M., Botje bz, E., Botta y, E., Braidot b, P., Braun Munzinger cn, M., Bregant dd, T., Breitner bd, T. A., Broker be, T. A., Browning cl, M., Broz ak, R., Brun ah, E., Bruna y, G. E., Bruno af, D., Budnikov cp, H., Buesching be, S., Bufalino y, P., Buncic ah, O., Busch cj, Z., Buthelezi cg, D., Caffarri ac, Cw, X., Cai h, H., Caines dz, E., Calvo Villar ct, Camerini, Paolo, V., Canoa Roman l, G., Cara Romeo cx, F., Carena ah, W., Carena ah, N., Carlin Filho dk, F., Carminati ah, A., Casanova Díaz bq, J., Castillo Castellanos o, J. F., Castillo Hernandez cn, E. A. R., Casula x, V., Catanescu bw, C., Cavicchioli ah, C., Ceballos Sanchez j, J., Cepila al, P., Cerello cv, B., Chang aq, Eb, S., Chapeland ah, J. L., Charvet o, S., Chattopadhyay dt, S., Chattopadhyay cr, M., Cherney cd, C., Cheshkov ah, Dm, B., Cheynis dm, V., Chibante Barroso ah, D. D., Chinellato dn, P., Chochula ah, M., Chojnacki by, S., Choudhury dt, P., Christakoglou bz, C. H., Christensen by, P., Christiansen ag, T., Chujo dr, S. U., Chung cm, C., Cicalo cy, L., Cifarelli ab, F., Cindolo cx, J., Cleymans cg, F., Colamaria af, D., Colella af, A., Collu x, G., Conesa Balbastre bp, Z., Conesa del Valle ah, Au, M. E., Connors dz, G., Contin w, J. G., Contreras l, T. M., Cormier dx, Y., Corrales Morales y, P., Cortese ae, I., Cortés Maldonado c, M. R., Cosentino b, F., Costa ah, M. E., Cotallo k, E., Crescio l, P., Crochet bo, E., Cruz Alaniz bi, R., Cruz Albino l, E., Cuautle bh, L., Cunqueiro bq, A., Dainese ac, H. H., Dalsgaard by, R., Dangh, A., Danubc, K., Dascr, I., Dasau, S., Dase, D., Dascr, A., Dashdl, S., Dasha, S., Dedt, G. O. V., de Barros dk, A., De Caro ad, G., de Cataldo da, J., de Cuveland an, A., De Falco x, D., De Gruttola ad, H., Delagrange dd, A., Deloff bv, N., De Marco cv, E., Dénes dy, S., De Pasquale ad, A., Deppman dk, G. D., Erasmo af, R., de Rooij ax, M. A., Diaz Corchero k, D., Di Bari af, T., Dietel bg, C., Di Giglio af, S., Di Liberto db, A., Di Mauro ah, P., Di Nezza bq, R., Divià ah, Ø., Djuvsland, A., Dobrin dx, Ag, Ax, T., Dobrowolski bv, B., Dönigus cn, O., Dordic v, O., Driga dd, A. K., Dubey dt, A., Dubla ax, L., Ducroux dm, P., Dupieux bo, A. K., Dutta Majumdar cr, D., Elia da, D., Emschermann bg, H., Engel bd, B., Erazmus ah, Dd, H. A., Erdal aj, D., Eschweiler an, B., Espagnon au, M., Estienne dd, S., Esumi dr, D., Evans c, S., Evdokimov av, G., Eyyubova v, D., Fabris ac, J., Faivre bp, D., Falchieri ab, A., Fantoni bq, M., Fasel cj, D., Fehlker, L., Feldkamp bg, D., Felea bc, A., Feliciello cv, B., Fenton Olsen b, G., Feofilov dv, A., Fernández Téllez c, A., Ferretti y, A., Festanti ac, J., Figiel dh, M. A. S., Figueredo dk, S., Filchagin cp, D., Finogeev aw, F. M., Fionda af, E. M., Fiore af, E., Floratos cf, M., Floris ah, S., Foertsch cg, P., Foka cn, S., Fokin cq, Fragiacomo, Enrico, A., Francescon ah, Ac, U., Frankenfeld cn, U., Fuchs ah, C., Furget bp, M., Fusco Girard ad, J. J., Gaardhøje by, M., Gagliardi y, A., Gago ct, M., Gallio y, D. R., Gangadharan t, P., Ganoti cb, C., Garabatos cn, E., Garcia Solis n, C., Gargiulo ah, I., Garishvili bt, J., Gerhard an, M., Germain dd, C., Geuna o, A., Gheata ah, M., Gheata bc, Ah, B., Ghidini af, P., Ghosh dt, P., Gianotti bq, M. R., Girard dw, P., Giubellino ah, E., Gladysz Dziadus dh, P., Glässel cj, R., Gomez dj, L, E. G., Ferreiro q, L. H., González Trueba bi, P., González Zamora k, S., Gorbunov an, A., Goswami ci, S., Gotovac df, L. K., Graczykowski dw, R., Grajcarek cj, A., Grelli ax, A., Grigoras ah, C., Grigoras ah, V., Grigoriev bu, A., Grigoryan b, S., Grigoryan bk, B., Grinyov d, N., Grion cz, P., Gros ag, J. F., Grosse Oetringhaus ah, J. Y., Grossiord dm, R., Grosso ah, F., Guber aw, R., Guernane bp, B., Guerzoni ab, M., Guilbaud dm, K., Gulbrandsen by, H., Gulkanyan b, T., Gunji dq, R., Gupta ch, A., Gupta ch, R., Haake bg, Ø., Haaland, C., Hadjidakis au, M., Haiduc bc, H., Hamagaki dq, G., Hamar dy, B. H., Han u, L. D., Hanratty c, A., Hansen by, Z., Harmanová Tóthová am, J. W., Harris dz, M., Hartig be, A., Harton n, D., Hatzifotiadou cx, S., Hayashi dq, A., Hayrapetyan ah, B, S. T., Heckel be, M., Heide bg, H., Helstrup aj, A., Herghelegiu bw, G., Herrera Corral l, N., Herrmann cj, B. A., Hess d, K. F., Hetland aj, B., Hicks dz, B., Hippolyte bj, Y., Hori dq, P., Hristov ah, I., Hrˇivnácˇová au, M., Huang, T. J., Humanic t, D. S., Hwang u, R., Ichou bo, R., Ilkaev cp, I., Ilkiv bv, M., Inaba dr, E., Incani x, P. G., Innocenti ah, G. M., Innocenti y, M., Ippolitov cq, M., Irfan r, C., Ivan cn, V., Ivanov cc, A., Ivanov dv, M., Ivanov cn, O., Ivanytskyi d, A., Jachołkowski aa, P. M., Jacobs b, C., Jahnke dk, H. J., Jang bm, M. A., Janik dw, P. H. S. Y., Jayarathna dn, S., Jena a, D. M., Jha dx, R. T., Jimenez Bustamante bh, P. G., Jones c, H., Jung ao, A., Jusko c, A. B., Kaidalov ay, S., Kalcher an, P., Kalinˇák az, T., Kalliokoski aq, A., Kalweit ah, J. H., Kang eb, V., Kaplin bu, S., Kar dt, A., Karasu Uysal ah, Ea, Bn, O., Karavichev aw, T., Karavicheva aw, E., Karpechev aw, A., Kazantsev cq, U., Kebschull bd, R., Keidel ec, B., Ketzer be, Dg, K. H., Khan p, M. M., Khan r, P., Khan cr, S. A., Khan dt, A., Khanzadeev cc, Y., Kharlov av, B., Kileng aj, M., Kim eb, S., Kim u, B., Kim eb, T., Kim eb, D. J., Kim aq, D. W., Kim ao, Bm, J. H., Kim u, J. S., Kim ao, M., Kim ao, S., Kirsch an, I., Kisel an, S., Kiselev ay, A., Kisiel dw, J. L., Klay g, J., Klein cj, C., Klein Bösing bg, M., Kliemant be, A., Kluge ah, M. L., Knichel cn, A. G., Knospe di, M. K., Köhler cn, T., Kollegger an, A., Kolojvari dv, M., Kompaniets dv, V., Kondratiev dv, N., Kondratyeva bu, A., Konevskikh aw, V., Kovalenko dv, M., Kowalski dh, S., Kox bp, G., Koyithatta Meethaleveedu a, J., Kral aq, I., Králik az, F., Kramer be, A., Kravcˇáková am, M., Krelina al, M., Kretz an, M., Krivda c, Az, F., Krizek aq, M., Krus al, E., Kryshen cc, M., Krzewicki cn, V., Kucera ca, Y., Kucheriaev cq, T., Kugathasan ah, C., Kuhn bj, P. G., Kuijer bz, I., Kulakov be, J., Kumar a, P., Kurashvili bv, A., Kurepin aw, A. B., Kurepin aw, A., Kuryakin cp, S., Kushpil ca, V., Kushpil ca, H., Kvaerno v, M. J., Kweon cj, Y., Kwon eb, P., Ladrón de Guevara bh, I., Lakomov au, R., Langoy, Du, S. L., La Pointe ax, C., Lara bd, A., Lardeux dd, P., La Rocca aa, Lea, Ramona, M., Lechman ah, S. C., Lee ao, G. R., Lee c, I., Legrand ah, J., Lehnert be, R. C., Lemmon dc, M., Lenhardt cn, V., Lenti da, H., León bi, M., Leoncino y, I., León Monzón dj, P., Lévai dy, S., Li bo, H, J., Lien, R., Lietava c, S., Lindal v, V., Lindenstruth an, C., Lippmann cn, M. A., Lisa t, H. M., Ljunggren ag, D. F., Lodato ax, P. I., Loenne, V. R., Loggins dx, V., Loginov bu, D., Lohner cj, C., Loizides b, K. K., Loo aq, X., Lopez bo, E., López Torres j, G., Løvhøiden v, X. G., Lu cj, P., Luettig be, M., Lunardon ac, J., Luo h, Luparello, Grazia, C., Luzzi ah, K., Ma h, R., Ma dz, D. M., Madagodahettige Don dn, A., Maevskaya aw, M., Mager bf, D. P., Mahapatra ba, A., Maire cj, M., Malaev cc, I., Maldonado Cervantes bh, Ludmila Malinina, Bk, D., Mal’Kevich ay, P., Malzacher cn, A., Mamonov cp, L., Manceau cv, L., Mangotra ch, V., Manko cq, F., Manso bo, V., Manzari da, Y., Mao h, M., Marchisone bo, Y, J., Mareš bb, Margagliotti, Giacomo, Cz, A., Margotti cx, A., Marín cn, C., Markert di, M., Marquard be, I., Martashvili dp, N. A., Martin cn, P., Martinengo ah, M. I., Martínez c, G., Martínez García dd, Y., Martynov d, A., Mas dd, S., Masciocchi cn, M., Masera y, A., Masoni cy, L., Massacrier dd, A., Mastroserio af, A., Matyja dh, C., Mayer dh, J., Mazer dp, M. A., Mazzoni db, F., Meddi z, A., Menchaca Rocha bi, J., Mercado Pérez cj, M., Meres ak, Y., Miake dr, K., Mikhaylov bk, Ay, L., Milano ah, Jovan Milosevic, V, A., Mischke ax, A. N., Mishra ci, At, D., Mis ́kowiec cn, C., Mitu bc, S., Mizuno dr, J., Mlynarz dx, B., Mohanty dt, Bx, L., Molnar dy, Bj, L., Montaño Zetina l, M., Monteno cv, E., Montes k, T., Moon eb, M., Morando ac, D. A., Moreira De Godoy dk, S., Moretto ac, A., Morreale aq, A., Morsch ah, V., Muccifora bq, E., Mudnic df, S., Muhuri dt, M., Mukherjee dt, H., Müller ah, M. G., Munhoz dk, S., Murray cg, L., Musa ah, J., Musinsky az, B. K., Nandi a, R., Nania cx, E., Nappi da, C., Nattrass dp, T. K., Nayak dt, S., Nazarenko cp, A., Nedosekin ay, M., Nicassio af, Cn, M., Niculescu bc, B. S., Nielsen by, T., Niida dr, S., Nikolaev cq, V., Nikolic co, S., Nikulin cq, V., Nikulin cc, B. S., Nilsen cd, M. S., Nilsson v, F., Noferini cx, P., Nomokonov bk, G., Nooren ax, A., Nyanin cq, A., Nyatha a, C., Nygaard by, J., Nystrand, A., Ochirov dv, H., Oeschler bf, Ah, Cj, S., Oh dz, S. K., Oh ao, J., Oleniacz dw, A. C., Oliveira Da Silva dk, C., Oppedisano cv, A., Ortiz Velasquez ag, Bh, A., Oskarsson ag, P., Ostrowski dw, J., Otwinowski cn, K., Oyama cj, K., Ozawa dq, Y., Pachmayer cj, M., Pachr al, F., Padilla y, P., Pagano ad, G., Paic ́ bh, F., Painke an, C., Pajares q, S. K., Pal dt, A., Palaha c, A., Palmeri cu, V., Papikyan b, G. S., Pappalardo cu, W. J., Park cn, A., Passfeld bg, D. I., Patalakha av, V., Paticchio da, B., Paul cr, A., Pavlinov dx, T., Pawlak dw, T., Peitzmann ax, H., Pereira Da Costa o, E., Pereira De Oliveira Filho dk, D., Peresunko cq, C. E., Pérez Lara bz, D., Perrino af, W., Peryt dw, A., Pesci cx, Y., Pestov f, V., Petrácˇek al, M., Petran al, M., Petris bw, P., Petrov c, M., Petrovici bw, C., Petta aa, Piano, Stefano, M., Pikna ak, P., Pillot dd, O., Pinazza ah, L., Pinsky dn, N., Pitz be, D. B., Piyarathna dn, M., Planinic co, M., Płoskon ́ b, J., Pluta dw, T., Pocheptsov bk, S., Pochybova dy, P. L. M., Podesta Lerma dj, M. G., Poghosyan ah, K., Polák bb, B., Polichtchouk av, N., Poljak ax, Co, A., Pop bw, S., Porteboeuf Houssais bo, V., Pospíšil al, B., Potukuchi ch, S. K., Prasad dx, R., Preghenella cx, F., Prino cv, C. A., Pruneau dx, I., Pshenichnov aw, G., Puddu x, V., Punin cp, M., Putiš am, J., Putschke dx, H., Qvigstad v, A., Rachevski cz, A., Rademakers ah, T. S., Räihä aq, J., Rak aq, A., Rakotozafindrabe o, L., Ramello ae, S., Raniwala ci, R., Raniwala ci, S. S., Räsänen aq, B. T., Rascanu be, D., Rathee ce, W., Rauch ah, K. F., Read dp, J. S., Real bp, K., Redlich bv, R. J., Reed dz, A., Rehman, P., Reichelt be, M., Reicher ax, R., Renfordt be, A. R., Reolon bq, A., Reshetin aw, F., Rettig an, J. P., Revol ah, K., Reygers cj, L., Riccati cv, R. A., Ricci br, T., Richert ag, M., Richter v, P., Riedler ah, W., Riegler ah, F., Riggi aa, Cu, M., Rodríguez Cahuantzi c, A., Rodriguez Manso bz, K., Røed, V, E., Rogochaya bk, D., Rohr an, D., Röhrich, R., Romita cn, Dc, F., Ronchetti bq, P., Rosnet bo, S., Rossegger ah, A., Rossi ah, P., Roy cr, C., Roy bj, A. J., Rubio Montero k, Rui, Rinaldo, R., Russo y, E., Ryabinkin cq, A., Rybicki dh, S., Sadovsky av, K., Šafarˇík ah, R., Sahoo at, P. K., Sahu ba, J., Saini dt, H., Sakaguchi ar, S., Sakai b, D., Sakata dr, C. A., Salgado q, J., Salzwedel t, S., Sambyal ch, V., Samsonov cc, X., Sanchez Castro bj, L., Šándor az, A., Sandoval bi, M., Sano dr, G., Santagati aa, R., Santoro ah, J., Sarkamo aq, D., Sarkar dt, E., Scapparone cx, F., Scarlassara ac, R. P., Scharenberg cl, C., Schiaua bw, R., Schicker cj, H. R., Schmidt d, C., Schmidt cn, S., Schuchmann be, J., Schukraft ah, T., Schuster dz, Y., Schutz ah, K., Schwarz cn, K., Schweda cn, G., Scioli ab, E., Scomparin cv, R., Scott dp, P. A., Scott c, G., Segato ac, I., Selyuzhenkov cn, S., Senyukov bj, J., Seo cm, S., Serci x, E., Serradilla k, Bi, A., Sevcenco bc, A., Shabetai dd, G., Shabratova bk, R., Shahoyan ah, N., Sharma dp, S., Sharma ch, S., Rohni ch, K., Shigaki ar, K., Shtejer j, Y., Sibiriak cq, E., Sicking bg, S., Siddhanta cy, T., Siemiarczuk bv, D., Silvermyr cb, C., Silvestre bp, G., Simatovic bh, G., Simonetti ah, R., Singaraju dt, R., Singh ch, S., Singha dt, V., Singhal dt, B. C., Sinha dt, T., Sinha cr, B., Sitar ak, M., Sitta ae, T. B., Skaali v, K., Skjerdal, R., Smakal al, N., Smirnov dz, R. J. M., Snellings ax, C., Søgaard ag, R., Soltz bt, M., Song eb, J., Song cm, C., Soos ah, F., Soramel ac, I., Sputowska dh, M., Spyropoulou Stassinaki cf, B. K., Srivastava cl, J., Stachel cj, I., Stan bc, G., Stefanek bv, M., Steinpreis t, E., Stenlund ag, G., Steyn cg, J. H., Stiller cj, D., Stocco dd, M., Stolpovskiy av, P., Strmen ak, A. A. P., Suaide dk, M. A., Subieta Vásquez y, T., Sugitate ar, C., Suire au, R., Sultanov ay, M., Šumbera ca, T., Susa co, T. J. M., Symons b, A., Szanto de Toledo dk, I., Szarka ak, A., Szczepankiewicz dh, M., Szyman ́ ski dw, J., Takahashi dl, M. A., Tangaro af, J. D., Tapia Takaki au, A., Tarantola Peloni be, A., Tarazona Martinez ah, A., Tauro ah, G., Tejeda Muñoz c, A., Telesca ah, A., Ter Minasyan cq, C., Terrevoli af, J., Thäder cn, D., Thomas ax, R., Tieulent dm, A. R., Timmins dn, D., Tlusty al, A., Toia an, Ac, Cw, H., Torii dq, L., Toscano cv, V., Trubnikov d, D., Truesdale t, W. H., Trzaska aq, T., Tsuji dq, A., Tumkin cp, R., Turrisi cw, T. S., Tveter v, J., Ulery be, K., Ullaland, J., Ulrich bl, Bd, A., Uras dm, G. M., Urciuoli db, G. L., Usai x, M., Vajzer al, Ca, M., Vala bk, L., Valencia Palomo au, P., Vande Vyvre ah, J. W., Van Hoorne ah, M., van Leeuwen ax, L., Vannucci br, A., Vargas c, R., Varma a, M., Vasileiou cf, A., Vasiliev cq, V., Vechernin dv, M., Veldhoen ax, M., Venaruzzo w, E., Vercellin y, S., Vergara c, R., Vernet i, M., Verweij ax, L., Vickovic df, G., Viesti ac, J., Viinikainen aq, Z., Vilakazi cg, O., Villalobos Baillie c, Y., Vinogradov cp, L., Vinogradov dv, A., Vinogradov cq, T., Virgili ad, Y. P., Viyogi dt, A., Vodopyanov bk, M. A., Völkl cj, S., Voloshin dx, K., Voloshin ay, G., Volpe ah, B., von Haller ah, I., Vorobyev dv, D., Vranic cn, J., Vrláková am, B., Vulpescu bo, A., Vyushin cp, B., Wagner, V., Wagner al, R., Wan h, Y., Wang h, M., Wang h, Y., Wang cj, K., Watanabe dr, M., Weber dn, J. P., Wessels ah, Bg, U., Westerhoff bg, J., Wiechula d, J., Wikne v, M., Wilde bg, G., Wilk bv, M. C. S., Williams cx, B., Windelband cj, L., Xaplanteris Karampatsos di, C. G., Yaldo dx, Y., Yamaguchi dq, S., Yang, P., Yang h, H., Yang o, Ax, S., Yasnopolskiy cq, J., Yi cm, Z., Yin h, I. K., Yoo cm, J., Yoon eb, W., Yu be, X., Yuan h, I., Yushmanov cq, Zaccolo by, V., C., Zach al, C., Zampolli cx, S., Zaporozhets bk, A., Zarochentsev dv, P., Závada bb, N., Zaviyalov cp, H., Zbroszczyk dw, P., Zelnicek bd, I. S., Zgura bc, M., Zhalov cc, H., Zhang h, X., Zhang b, Bo, H, Y., Zhang h, D., Zhou h, F., Zhou h, Y., Zhou ax, H., Zhu h, J., Zhu h, X., Zhu h, A., Zichichi ab, A., Zimmermann cj, G., Zinovjev d, Y., Zoccarato dm, M., Zynovyev d, and M., Zyzak

Subjects
Charged-particle density, Heavy-ion collisions, LHC, Wide rapidity coverage, Nuclear and High Energy Physics, HEAVY-ION COLLISIONS, Charged-Particle Density, Heavy ions collisions, charged-particle density, Nuclear Experiment
Abstract

We present the first wide-range measurement of the charged-particle pseudorapidity density distribution, for different centralities (the 0–5%, 5–10%, 10–20%, and 20–30% most central events) in Pb–Pb collisions at √sNN = 2.76 TeV at the LHC. The measurement is performed using the full coverage of the ALICE detectors, −5.0 < η < 5.5, and employing a special analysis technique based on collisions arising from LHC ‘satellite’ bunches. We present the pseudorapidity density as a function of the number of participating nucleons as well as an extrapolation to the total number of produced charged particles (Nch = 17 165 ± 772 for the 0–5% most central collisions). From the measured dNch/dη distribution we derive the rapidity density distribution, dNch/dy, under simple assumptions. The rapidity density distribution is found to be significantly wider than the predictions of the Landau model. We assess the validity of longitudinal scaling by comparing to lower energy results from RHIC. Finally the mechanisms of the underlying particle production are discussed based on a comparison with various theoretical models.

Published
2013

42. Academic, clinical and personal experiences of undergraduate healthcare students during the COVID-19 pandemic: A prospective cohort study.

Author

McFadden S, Guille S, Daly-Lynn J, O'Neill B, Marley J, Hanratty C, Shepherd P, Ramsey L, Breen C, Duffy O, Jones A, Kerr D, and Hughes C

Subjects
Cross-Sectional Studies, Delivery of Health Care, Humans, Pandemics, Prospective Studies, Students, COVID-19 epidemiology
Abstract

Background: Coronavirus disease 2019 has impacted upon the role and safety of healthcare workers, with the potential to have a lasting effect on their wellbeing. Limited research has been conducted during previous pandemics exploring how student healthcare workers are impacted as they study and train for their professional careers., Objective: The aim of the current study was to examine the specific impact of COVID-19 on the academic, clinical and personal experiences of healthcare students., Method: Undergraduate students across three year groups within the School of Health Sciences at Ulster University completed online Qualtrics surveys at three timepoints during one academic year (2020/2021). Quantitative survey data was downloaded from Qualtrics into SPSS Version 25 for descriptive analysis of each cross-sectional sample. Qualitative survey data was downloaded into text format, which was thematically analysed using content analysis., Results: 412 students completed the survey at Time 1 (October 2020), n = 309 at Time 2 (December 2020) and n = 259 at Time 3 (April 2021). Academically, the pandemic had mostly a negative impact on the learning environment, the development of practical skills, the assessment process and opportunities for peer learning and support. Students reported increased stress and challenges managing their workload and maintaining a sense of motivation and routine. Clinically, they felt unprepared by the university for placement where the pandemic had an increasingly negative impact over time on learning and skill development. In terms of personal experiences, despite the majority of students taking steps to keep physically and mentally well, negative impacts on friendships, mental wellbeing and concerns for family were reported. The pandemic had not impacted upon career choice for most students., Conclusion: Consideration must be given to the development of practical skills so students feel prepared for their professional careers given the practical nature of their roles. Programme coordinators should adopt a holistic approach to student wellbeing., Competing Interests: The authors have declared that no competing interests exist.

Published
2022
Full Text
View/download PDF

43. Coronary Artery Ectasia: Review of the Non-Atherosclerotic Molecular and Pathophysiologic Concepts.

Author

Richards GHC, Hong KL, Henein MY, Hanratty C, and Boles U

Subjects
Coronary Angiography, Dilatation, Pathologic, Humans, Coronary Artery Disease diagnosis, Coronary Vessels
Abstract

Coronary artery ectasia (CAE) is frequently encountered in clinical practice, conjointly with atherosclerotic CAD (CAD). Given the overlapping cardiovascular risk factors for patients with concomitant CAE and atherosclerotic CAD, a common underlying pathophysiology is often postulated. However, coronary artery ectasia may arise independently, as isolated (pure) CAE, thereby raising suspicions of an alternative mechanism. Herein, we review the existing evidence for the pathophysiology of CAE in order to help direct management strategies towards enhanced detection and treatment.

Published
2022
Full Text
View/download PDF

44. Defining Percutaneous Coronary Intervention Complexity and Risk: An Analysis of the United Kingdom BCIS Database 2006-2016.

Author

Protty M, Sharp ASP, Gallagher S, Farooq V, Spratt JC, Ludman P, Anderson R, McEntegart MM, Hanratty C, Walsh S, Curzen N, Smith E, Mamas M, and Kinnaird T

Subjects
Aged, 80 and over, Female, Humans, Risk Factors, Treatment Outcome, United Kingdom epidemiology, Atherectomy, Coronary, Coronary Artery Disease diagnostic imaging, Coronary Artery Disease etiology, Coronary Artery Disease therapy, Percutaneous Coronary Intervention adverse effects
Abstract

Objectives: The authors used the BCIS (British Cardiovascular Intervention Society) database to define the factors associated with percutaneous coronary intervention (PCI) procedural complexity., Background: Complex high-risk indicated percutaneous coronary intervention (CHIP-PCI) is an emerging concept that is poorly defined., Methods: The BCIS (British Cardiovascular Intervention Society) database was used to study all PCI procedures in the United Kingdom 2006-2016. A multiple logistic regression model was developed to identify variables associated with in-hospital major adverse cardiac or cerebrovascular events (MACCE) and to construct a CHIP score. The cumulative effect of this score on patient outcomes was examined., Results: A total of 313,054 patients were included. Seven patient factors (age ≥80 years, female sex, previous stroke, previous myocardial infarction, peripheral vascular disease, ejection fraction <30%, and chronic renal disease) and 6 procedural factors (rotational atherectomy, left main PCI, 3-vessel PCI, dual arterial access, left ventricular mechanical support, and total lesion length >60 mm) were associated with increased in-hospital MACCE and defined as CHIP factors. The mean CHIP score/case for all PCIs increased significantly from 1.06 ± 1.32 in 2006 to 1.49 ± 1.58 in 2016 (P < 0.001 for trend). A CHIP score of 5 or more was present in 2.5% of procedures in 2006 increasing to 5.3% in 2016 (P < 0.001 for trend). Overall in-hospital MACCE was 0.6% when the CHIP score was 0 compared with 1.2% with any CHIP factor present (P < 0.001). As the CHIP score increased, an exponential increase in-hospital MACCE was observed. The cumulative MACCE for procedures associated with a CHIP score 4+ or above was 3.2%, and for a CHIP score 5+ was 4.4%. All other adverse clinical outcomes were more likely as the CHIP score increased., Conclusions: Seven patient factors and 6 procedural factors were associated with adverse in-hospital MACCE and defined as CHIP factors. Use of a CHIP score might be a future target for risk modification., Competing Interests: Funding Support and Author Disclosures The authors have reported that they have no relationships relevant to the contents of this paper to disclose., (Copyright © 2022 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.)

Published
2022
Full Text
View/download PDF

45. There is No Link Between Birth Weight and Developmental Dysplasia of the Hip.

Author

Hanratty C, Thyagarajan B, Clarke NM, and Aarvold A

Abstract

Aims: Developmental Dysplasia of the Hip (DDH) has been linked to high birth weight and packaging disorders, though the evidence is limited. This has implications on screening strategies. The aim of this study was to establish whether birth weight was truly associated with the incidence of DDH., Patients and Methods: This cohort study analysed the birth weights of all babies born at our institution over a 24 month period, between 01/01/2017 and 01/01/2019. Babies with DDH and those without DDH were compared. Babies were excluded if born before 38 weeks, had incomplete data or were a non-singleton pregnancy. Sub-analysis was performed for DDH severity (dysplastic versus subluxed/dislocated hips), breech presentation, gestational age, gender and ethnicity. Statistical analysis was performed using SPSS., Results: There were 10,113 babies born at our institution during the selected timeframe, of which 884 were excluded for prematurity, 336 for being non-singleton and 19 for incomplete data. This left 8874 for analysis, of which 95 babies had confirmed DDH. Both the Non-DDH and DDH data sets had normal distribution (Shapiro-Wilkes, p  = 0.308 and 0.629, respectively), with mean birth weights of 3477.7 g with DDH and 3492.8 g without DDH. No difference in birth weight was found (Independent T test, p  = 0.789). Females had a lower birth weight than males (3293.1 g versus 3416.6 g ( p  < 0.001)) yet have a higher incidence of DDH (ratio 6:1 in this dataset). No significant difference was found between birth weights of females with and without DDH ( p  = 0.068), nor between males with and without DDH ( p  = 0.513). There were no significant differences in birth weights even when only displaced hips were analysed ( p  = 0.543), nor according to breech presentation ( p  = 0.8). Longer gestation babies weighed more ( p  < 0.00001), yet showed no increase in DDH incidence ( p  = 0.64)., Conclusion: This study discredits the belief that DDH may be related to higher birth weight, thus casting doubt on the link to DDH being a packaging problem in utero. This, therefore, allows future research to prioritise the investigation of alternative aetiologies., Competing Interests: Conflict of InterestOn behalf of all authors, the corresponding author states that there is no conflict of interest., (© The Author(s) 2021.)

Published
2021
Full Text
View/download PDF

46. Intravascular Lithotripsy for Calcium Modification in Chronic Total Occlusion Percutaneous Coronary Intervention.

Author

Øksnes A, Cosgrove C, Walsh S, Løland KH, Laffan J, Biswas S, Shaukat A, Hanratty C, Strange J, Spratt JCS, and McEntegart M

Subjects
Aged, Coronary Artery Disease therapy, Female, Humans, Intraoperative Complications, Male, Postoperative Complications, Registries, Retrospective Studies, Coronary Occlusion therapy, Lithotripsy methods, Percutaneous Coronary Intervention, Vascular Calcification therapy
Abstract

Intravascular lithotripsy (IVL) has been shown to be safe and effective for calcium modification in nonocclusive coronary artery disease (CAD), but there are only case reports of its use in calcified chronic total occlusions (CTO). We report data from an international multicenter registry of IVL use during CTO percutaneous coronary intervention (PCI) and provide provisional data regarding its efficacy and safety. During the study period, IVL was used in 55 of 1053 (5.2%) CTO PCI procedures. IVL was used within the occluded segment after successful CTO crossing in 53 procedures and during incomplete CTO crossing in 2 cases. The mean J-CTO score was 3.1. CTO PCI technical and procedural success was achieved in 53 (96%) and 51 (93%) cases. Six patients had a procedural complication, with 3 main vessel perforations (5%). Two had covered stent implantation, one required pericardiocentesis, and one was managed conservatively. All had combination therapy with another calcium modification device. Two patients had a procedural myocardial infarction (PMI) (4%), and two others had a major adverse cardiovascular event (MACE) (4%) at a median follow-up of 13 (4-21) months. IVL can effectively facilitate calcium modification during CTO PCI. More data are required to establish the efficacy and safety of IVL and other calcium modification devices when used extraplaque or in combination during CTO PCI., Competing Interests: AØ has a proctoring agreement with Boston Scientific and EPS Vascular. CC received an educational grant from Shockwave Medical. SW, JS, JS, CH, and MM have consultancy agreement with Boston Scientific, Abbott Vascular, Teleflex, and Shockwave Medical. All other authors have no conflicts of interest., (Copyright © 2021 Anja Øksnes et al.)

Published
2021
Full Text
View/download PDF

47. Definitions and Clinical Trial Design Principles for Coronary Artery Chronic Total Occlusion Therapies: CTO-ARC Consensus Recommendations.

Author

Ybarra LF, Rinfret S, Brilakis ES, Karmpaliotis D, Azzalini L, Grantham JA, Kandzari DE, Mashayekhi K, Spratt JC, Wijeysundera HC, Ali ZA, Buller CE, Carlino M, Cohen DJ, Cutlip DE, De Martini T, Di Mario C, Farb A, Finn AV, Galassi AR, Gibson CM, Hanratty C, Hill JM, Jaffer FA, Krucoff MW, Lombardi WL, Maehara A, Magee PFA, Mehran R, Moses JW, Nicholson WJ, Onuma Y, Sianos G, Sumitsuji S, Tsuchikane E, Virmani R, Walsh SJ, Werner GS, Yamane M, Stone GW, Rinfret S, and Stone GW

Subjects
Clinical Trials as Topic, Female, Humans, Male, Coronary Occlusion therapy, Coronary Vessels physiology
Abstract

Over the past 2 decades, chronic total occlusion (CTO) percutaneous coronary intervention has developed into its own subspecialty of interventional cardiology. Dedicated terminology, techniques, devices, courses, and training programs have enabled progressive advancements. However, only a few randomized trials have been performed to evaluate the safety and efficacy of CTO percutaneous coronary intervention. Moreover, several published observational studies have shown conflicting data. Part of the paucity of clinical data stems from the fact that prior studies have been suboptimally designed and performed. The absence of standardized end points and the discrepancy in definitions also prevent consistency and uniform interpretability of reported results in CTO intervention. To standardize the field, we therefore assembled a broad consortium comprising academicians, practicing physicians, researchers, medical society representatives, and regulators (US Food and Drug Administration) to develop methods, end points, biomarkers, parameters, data, materials, processes, procedures, evaluations, tools, and techniques for CTO interventions. This article summarizes the effort and is organized into 3 sections: key elements and procedural definitions, end point definitions, and clinical trial design principles. The Chronic Total Occlusion Academic Research Consortium is a first step toward improved comparability and interpretability of study results, supplying an increasingly growing body of CTO percutaneous coronary intervention evidence.

Published
2021
Full Text
View/download PDF

48. Management of stent underexpansion using intravascular lithotripsy-Defining the utility of a novel device.

Author

Yeoh J, Cottens D, Cosgrove C, Mallek K, Strange J, Anderson R, Wilson S, Hanratty C, Walsh S, McEntegart M, Hill J, and Spratt JC

Subjects
Aged, Coronary Angiography, Humans, Male, Stents, Treatment Outcome, Coronary Artery Disease diagnostic imaging, Coronary Artery Disease therapy, Lithotripsy adverse effects
Abstract

Objectives: This study aimed to present a case series of patient treated for stent underexpansion resistant to conventional treatment with intravascular lithotripsy (IVL)., Background: Stent underexpansion is a powerful predictor of long-term stent patency and correlates with unfavorable clinical outcomes. This case series demonstrates the utility of IVL in managing stent underexpansion resistant to conventional treatment., Methods: We describe a case series of patients with stent underexpansion due to calcific coronary artery disease treated with IVL. Stent underexpansion was identified as an inability to adequately expand stents with conventional treatment. Only cases that failed to achieve adequate expansion with high-pressure noncompliant balloon inflation were included., Results: Thirteen patients from six institutions have been included in this case series. The average age was 70.25 years with 76.9% of male patients. The average pre-IVL minimal stent area (MSA) was 2.71 mm 2 , which improved to 6.44 mm 2 post-IVL treatment, representing an average MSA gain of 238%. There were no procedural, peri-procedural, or 30-day major adverse cardiac and cerebrovascular event., Conclusion: This case series demonstrates that IVL is a feasible, safe alternative for the management of stent underexpansion due to calcific coronary disease., (© 2020 Wiley Periodicals, Inc.)

Published
2021
Full Text
View/download PDF

49. Complex high-risk and indicated percutaneous coronary intervention for stable angina: Does operator volume influence patient outcome?

Author

Kinnaird T, Gallagher S, Spratt JC, Ludman P, de Belder M, Copt S, Anderson R, Walsh S, Hanratty C, Curzen N, Banning A, and Mamas M

Subjects
Aged, Angina, Stable mortality, Databases, Factual, England epidemiology, Female, Follow-Up Studies, Hospital Mortality trends, Humans, Male, Retrospective Studies, Risk Factors, Survival Rate trends, Treatment Outcome, Wales epidemiology, Angina, Stable surgery, Percutaneous Coronary Intervention statistics & numerical data, Registries, Risk Assessment methods, Workload statistics & numerical data
Abstract

Background: Complex high-risk and indicated revascularization using percutaneous coronary intervention (CHIP-PCI) is an emerging concept that is poorly studied., Objective: To define temporal changes in CHIP-PCI volumes, and the relationship between operator CHIP-PCI volume and patient outcomes., Methods and Results: Data were analyzed on all CHIP-PCI procedures undertaken for stable angina in England and Wales between 2007 and 2014. Operator volume data was available for 2012-14. CHIP-PCI was defined by patient characteristics (age ≥80years, left ventricular (LV) ejection fraction <30%, previous CABG, or chronic renal failure) and/or by procedural characteristics (left main PCI, chronic total occlusion PCI, LV support, use of rotational atherectomy or laser atherectomy). CHIP-PCI as a percentage of total PCI increased from 28.1% in 2007 to 36.2% in 2014 (P < .001). Between 2012 and 2014, a total of 30,268 CHIP-PCI cases were performed. Total operator volume varied from 1 to 580 cases with median total operator volume of 29 cases. Higher operator volumes were associated with a greater degree of patient comorbidity and increasing procedural complexity. After adjustment for baseline difference, in-hospital major bleeding (P < .001 for trend), access site complications (P < .001) and coronary perforation (P = .002) were associated with increasing operator CHIP-PCI volumes. However, the frequency of in-hospital death (P = .394) and 12-month mortality (P = .638) were similar across the volume quartiles. Higher volumes quartiles were associated with a greater likelihood of same day discharge (P < .001)., Conclusions: CHIP-PCI cases are an increasingly large population in contemporary PCI practice. Higher operator volumes were not associated with improved 12-month survival., Condensed Abstract: Data were analyzed on all complex high-risk and indicated revascularization using percutaneous coronary intervention (CHIP-PCI) procedures in England and Wales between 2007 and 2014. CHIP-PCI as a percentage of total PCI increased from 28.1% in 2007 to 36.2% in 2014 (P < .001). Median total operator volume was 29 cases with higher volumes associated with more patient comorbidity and increasing procedural complexity. In-hospital major bleeding (P < .001 for trend), access site complications (P < .001) and coronary perforation (P = .002) all associated with increasing operator CHIP-PCI volumes. However, trends for in-hospital death (P = .394), and 12-month mortality (P = .638) were similar across the volume quartiles., (Copyright © 2020 Elsevier Inc. All rights reserved.)

Published
2020
Full Text
View/download PDF

50. Clinical outcomes of state-of-the-art percutaneous coronary revascularization in patients with de novo three vessel disease: 1-year results of the SYNTAX II study.

Author

Escaned J, Collet C, Ryan N, De Maria GL, Walsh S, Sabate M, Davies J, Lesiak M, Moreno R, Cruz-Gonzalez I, Hoole SP, Ej West N, Piek JJ, Zaman A, Fath-Ordoubadi F, Stables RH, Appleby C, van Mieghem N, van Geuns RJ, Uren N, Zueco J, Buszman P, Iñiguez A, Goicolea J, Hildick-Smith D, Ochala A, Dudek D, Hanratty C, Cavalcante R, Kappetein AP, Taggart DP, van Es GA, Morel MA, de Vries T, Onuma Y, Farooq V, Serruys PW, and Banning AP

Subjects
Absorbable Implants, Aged, Angioplasty, Balloon, Coronary methods, Atorvastatin therapeutic use, Coronary Artery Bypass methods, Drug Therapy, Combination, Drug-Eluting Stents, Female, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors therapeutic use, Male, Myocardial Infarction surgery, Platelet Aggregation Inhibitors therapeutic use, Rosuvastatin Calcium therapeutic use, Surgery, Computer-Assisted methods, Treatment Outcome, Ultrasonography, Interventional methods, Coronary Artery Disease surgery, Coronary Occlusion surgery, Percutaneous Coronary Intervention methods
Abstract

Aims: To investigate if recent technical and procedural developments in percutaneous coronary intervention (PCI) significantly influence outcomes in appropriately selected patients with three-vessel (3VD) coronary artery disease., Methods and Results: The SYNTAX II study is a multicenter, all-comers, open-label, single arm study that investigated the impact of a contemporary PCI strategy on clinical outcomes in patients with 3VD in 22 centres from four European countries. The SYNTAX-II strategy includes: heart team decision-making utilizing the SYNTAX Score II (a clinical tool combining anatomical and clinical factors), coronary physiology guided revascularisation, implantation of thin strut bioresorbable-polymer drug-eluting stents, intravascular ultrasound (IVUS) guided stent implantation, contemporary chronic total occlusion revascularisation techniques and guideline-directed medical therapy. The rate of major adverse cardiac and cerebrovascular events (MACCE [composite of all-cause death, cerebrovascular event, any myocardial infarction and any revascularisation]) at one year was compared to a predefined PCI cohort from the original SYNTAX-I trial selected on the basis of equipoise 4-year mortality between CABG and PCI. As an exploratory endpoint, comparisons were made with the historical CABG cohort of the original SYNTAX-I trial. Overall 708 patients were screened and discussed within the heart team; 454 patients were deemed appropriate to undergo PCI. At one year, the SYNTAX-II strategy was superior to the equipoise-derived SYNTAX-I PCI cohort (MACCE SYNTAX-II 10.6% vs. SYNTAX-I 17.4%; HR 0.58, 95% CI 0.39-0.85, P = 0.006). This difference was driven by a significant reduction in the incidence of MI (HR 0.27, 95% CI 0.11-0.70, P = 0.007) and revascularisation (HR 0.57, 95% CI 0.37-0.9, P = 0.015). Rates of all-cause death (HR 0.69, 95% CI 0.27-1.73, P = 0.43) and stroke (HR 0.69, 95% CI 0.10-4.89, P = 0.71) were similar. The rate of definite stent thrombosis was significantly lower in SYNTAX-II (HR 0.26, 95% CI 0.07-0.97, P = 0.045)., Conclusion: At one year, clinical outcomes with the SYNTAX-II strategy were associated with improved clinical results compared to the PCI performed in comparable patients from the original SYNTAX-I trial. Longer term follow-up is awaited and a randomized clinical trial with contemporary CABG is warranted., Clinicaltrials.gov Identifier: NCT02015832., (© The Author 2017. Published on behalf of the European Society of Cardiology)

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results