16 results on '"Hannani, Monica T."'
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2. Non-canonical Hedgehog signaling mediates profibrotic hematopoiesis-stroma crosstalk in myeloproliferative neoplasms
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Pritchard, Jessica E., Pearce, Juliette E., Snoeren, Inge A.M., Fuchs, Stijn N.R., Götz, Katrin, Peisker, Fabian, Wagner, Silke, Benabid, Adam, Lutterbach, Niklas, Klöker, Vanessa, Nagai, James S., Hannani, Monica T., Galyga, Anna K., Sistemich, Ellen, Banjanin, Bella, Flosdorf, Niclas, Bindels, Eric, Olschok, Kathrin, Biaesch, Katharina, Chatain, Nicolas, Bhagwat, Neha, Dunbar, Andrew, Sarkis, Rita, Naveiras, Olaia, Berres, Marie-Luise, Koschmieder, Steffen, Levine, Ross L., Costa, Ivan G., Gleitz, Hélène F.E., Kramann, Rafael, and Schneider, Rebekka K.
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- 2024
- Full Text
- View/download PDF
3. Spatial multi-omic map of human myocardial infarction
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Kuppe, Christoph, Ramirez Flores, Ricardo O., Li, Zhijian, Hayat, Sikander, Levinson, Rebecca T., Liao, Xian, Hannani, Monica T., Tanevski, Jovan, Wünnemann, Florian, Nagai, James S., Halder, Maurice, Schumacher, David, Menzel, Sylvia, Schäfer, Gideon, Hoeft, Konrad, Cheng, Mingbo, Ziegler, Susanne, Zhang, Xiaoting, Peisker, Fabian, Kaesler, Nadine, Saritas, Turgay, Xu, Yaoxian, Kassner, Astrid, Gummert, Jan, Morshuis, Michiel, Amrute, Junedh, Veltrop, Rogier J. A., Boor, Peter, Klingel, Karin, Van Laake, Linda W., Vink, Aryan, Hoogenboezem, Remco M., Bindels, Eric M. J., Schurgers, Leon, Sattler, Susanne, Schapiro, Denis, Schneider, Rebekka K., Lavine, Kory, Milting, Hendrik, Costa, Ivan G., Saez-Rodriguez, Julio, and Kramann, Rafael
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- 2022
- Full Text
- View/download PDF
4. From biochemical markers to molecular endotypes of osteoarthritis:a review on validated biomarkers
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Hannani, Monica T., Thudium, Christian S., Karsdal, Morten A., Ladel, Christoph, Mobasheri, Ali, Uebelhoer, Melanie, Larkin, Jonathan, Bacardit, Jaume, Struglics, André, Bay-Jensen, Anne Christine, Hannani, Monica T., Thudium, Christian S., Karsdal, Morten A., Ladel, Christoph, Mobasheri, Ali, Uebelhoer, Melanie, Larkin, Jonathan, Bacardit, Jaume, Struglics, André, and Bay-Jensen, Anne Christine
- Abstract
Introduction: Osteoarthritis (OA) affects over 500 million people worldwide. OA patients are symptomatically treated, and current therapies exhibit marginal efficacy and frequently carry safety-risks associated with chronic use. No disease-modifying therapies have been approved to date leaving surgical joint replacement as a last resort. To enable effective patient care and successful drug development there is an urgent need to uncover the pathobiological drivers of OA and how these translate into disease endotypes. Endotypes provide a more precise and mechanistic definition of disease subgroups than observable phenotypes, and a panel of tissue- and pathology-specific biochemical markers may uncover treatable endotypes of OA. Areas covered: We have searched PubMed for full-text articles written in English to provide an in-depth narrative review of a panel of validated biochemical markers utilized for endotyping of OA and their association to key OA pathologies. Expert opinion: As utilized in IMI-APPROACH and validated in OAI-FNIH, a panel of biochemical markers may uncover disease subgroups and facilitate the enrichment of treatable molecular endotypes for recruitment in therapeutic clinical trials. Understanding the link between biochemical markers and patient-reported outcomes and treatable endotypes that may respond to given therapies will pave the way for new drug development in OA.
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- 2024
5. From biochemical markers to molecular endotypes of osteoarthritis: a review on validated biomarkers
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Hannani, Monica T., primary, Thudium, Christian S., additional, Karsdal, Morten A., additional, Ladel, Christoph, additional, Mobasheri, Ali, additional, Uebelhoer, Melanie, additional, Larkin, Jonathan, additional, Bacardit, Jaume, additional, Struglics, André, additional, and Bay-Jensen, Anne-Christine, additional
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- 2024
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6. Non-Canonical Hedgehog Signaling Mediates Profibrotic Hematopoiesis-Stroma Crosstalk in Myeloproliferative Neoplasms
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Pritchard, Jessica E., primary, Pearce, Juliette E., additional, Snoeren, Inge A.M., additional, Fuchs, Stijn N.R., additional, Götz, Katrin, additional, Peisker, Fabian, additional, Wagner, Silke, additional, Benabid, Adam, additional, Lutterbach, Niklas, additional, Galyga, Anna K., additional, Nagai, James S., additional, Krämer, Vanessa, additional, Hannani, Monica T., additional, Bindels, Eric, additional, Olschok, Kathrin, additional, Chatain, Nicolas, additional, Bhagwat, Neha, additional, Dunbar, Andrew, additional, Berres, Marie-Luise, additional, Koschmieder, Steffen, additional, Levine, Ross L., additional, Costa, Ivan, additional, Gleitz, Hélène F.E., additional, Kramann, Rafael, additional, and Schneider, Rebekka, additional
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- 2023
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7. Dissecting CD8+ T cell pathology of severe SARS-CoV-2 infection by single-cell immunoprofiling
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Schreibing, Felix, primary, Hannani, Monica T., additional, Kim, Hyojin, additional, Nagai, James S., additional, Ticconi, Fabio, additional, Fewings, Eleanor, additional, Bleckwehl, Tore, additional, Begemann, Matthias, additional, Torow, Natalia, additional, Kuppe, Christoph, additional, Kurth, Ingo, additional, Kranz, Jennifer, additional, Frank, Dario, additional, Anslinger, Teresa M., additional, Ziegler, Patrick, additional, Kraus, Thomas, additional, Enczmann, Jürgen, additional, Balz, Vera, additional, Windhofer, Frank, additional, Balfanz, Paul, additional, Kurts, Christian, additional, Marx, Gernot, additional, Marx, Nikolaus, additional, Dreher, Michael, additional, Schneider, Rebekka K., additional, Saez-Rodriguez, Julio, additional, Costa, Ivan, additional, Hayat, Sikander, additional, and Kramann, Rafael, additional
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- 2022
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8. Processed Data 2 : Spatial multi-omic map of human myocardial infarction
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Kuppe, Christoph, Flores, Ricardo O. Ramirez, Zhijian Li, Sikander Hayat, Levinson, Rebecca T., Liao, Xian, Hannani, Monica T., Tanevski, Jovan, Wünnemann, Florian, Nagai, James S., Halder, Maurice, Schumacher, David, Menzel, Sylvia, Schäfer, Gideon, Hoeft, Konrad, Mingbo Cheng, Ziegler, Susanne, Xiaoting Zhang, Peisker, Fabian, Kaesler, Nadine, Saritas, Turgay, Yaoxian Xu, Kassner, Astrid, Gummert, Jan, Morshuis, Michiel, Junedh Amrute, Veltrop, Rogier J. A., Boor, Peter, Klingel, Karin, Van Laake, Linda W., Vink, Aryan, Hoogenboezem, Remco M., Bindels, Eric M.J., Schurgers, Leon, Sattler, Susanne, Schapiro, Denis, Schneider, Rebekka K., Lavine, Kory, Milting, Hendrik, Costa, Ivan G., Saez-Rodriguez, Julio, and Kramann, Rafael
- Abstract
We provide here the sub-clustering results for each major cell type forthe manuscript: Kuppe, Ramirez Flores, Li et al. "Spatial multi-omic map of human myocardial infarction", 2022. The cells from snRNA-seq and snATAC-seq were first integrated and then sub-clustering was performed based on the integrated data. We tried our best to annotated the obtained sub-clusters.
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- 2022
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9. Raw Data - Part 3 : Spatial multi-omic map of human myocardial infarction
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Kuppe, Christoph, Flores, Ricardo O. Ramirez, Zhijian Li, Sikander Hayat, Levinson, Rebecca T., Liao, Xian, Hannani, Monica T., Tanevski, Jovan, Wünnemann, Florian, Nagai, James S., Halder, Maurice, Schumacher, David, Menzel, Sylvia, Schäfer, Gideon, Hoeft, Konrad, Mingbo Cheng, Ziegler, Susanne, Xiaoting Zhang, Peisker, Fabian, Kaesler, Nadine, Saritas, Turgay, Yaoxian Xu, Kassner, Astrid, Gummert, Jan, Morshuis, Michiel, Junedh Amrute, Veltrop, Rogier J. A., Boor, Peter, Klingel, Karin, Van Laake, Linda W., Vink, Aryan, Hoogenboezem, Remco M., Bindels, Eric M.J., Schurgers, Leon, Sattler, Susanne, Schapiro, Denis, Schneider, Rebekka K., Lavine, Kory, Milting, Hendrik, Costa, Ivan G., Saez-Rodriguez, Julio, and Kramann, Rafael
- Abstract
We provide here the raw data of visium forthe manuscript: Kuppe, Ramirez Flores, Li et al. "Spatial multi-omic map of human myocardial infarction", 2022
- Published
- 2022
- Full Text
- View/download PDF
10. Dissecting CD8+ T cell pathology of severe SARS-CoV-2 infection by single-cell immunoprofiling
- Author
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Schreibing, Felix, Hannani, Monica T., Kim, Hyojin, Nagai, James S., Ticconi, Fabio, Fewings, Eleanor, Bleckwehl, Tore, Begemann, Matthias, Torow, Natalia, Kuppe, Christoph, Kurth, Ingo, Kranz, Jennifer, Frank, Dario, Anslinger, Teresa M., Ziegler, Patrick, Kraus, Thomas, Enczmann, Jürgen, Balz, Vera, Windhofer, Frank, Balfanz, Paul, Kurts, Christian, Marx, Gernot, Marx, Nikolaus, Dreher, Michael, Schneider, Rebekka K., Saez-Rodriguez, Julio, Costa, Ivan, Hayat, Sikander, Kramann, Rafael, Schreibing, Felix, Hannani, Monica T., Kim, Hyojin, Nagai, James S., Ticconi, Fabio, Fewings, Eleanor, Bleckwehl, Tore, Begemann, Matthias, Torow, Natalia, Kuppe, Christoph, Kurth, Ingo, Kranz, Jennifer, Frank, Dario, Anslinger, Teresa M., Ziegler, Patrick, Kraus, Thomas, Enczmann, Jürgen, Balz, Vera, Windhofer, Frank, Balfanz, Paul, Kurts, Christian, Marx, Gernot, Marx, Nikolaus, Dreher, Michael, Schneider, Rebekka K., Saez-Rodriguez, Julio, Costa, Ivan, Hayat, Sikander, and Kramann, Rafael
- Abstract
Introduction: SARS-CoV-2 infection results in varying disease severity, ranging from asymptomatic infection to severe illness. A detailed understanding of the immune response to SARS-CoV-2 is critical to unravel the causative factors underlying differences in disease severity and to develop optimal vaccines against new SARS-CoV-2 variants. Methods: We combined single-cell RNA and T cell receptor sequencing with CITE-seq antibodies to characterize the CD8+ T cell response to SARS-CoV-2 infection at high resolution and compared responses between mild and severe COVID-19. Results: We observed increased CD8+ T cell exhaustion in severe SARS-CoV-2 infection and identified a population of NK-like, terminally differentiated CD8+ effector T cells characterized by expression of FCGR3A (encoding CD16). Further characterization of NK-like CD8+ T cells revealed heterogeneity among CD16+ NK-like CD8+ T cells and profound differences in cytotoxicity, exhaustion, and NK-like differentiation between mild and severe disease conditions. Discussion: We propose a model in which differences in the surrounding inflammatory milieu lead to crucial differences in NK-like differentiation of CD8+ effector T cells, ultimately resulting in the appearance of NK-like CD8+ T cell populations of different functionality and pathogenicity. Our in-depth characterization of the CD8+ T cell-mediated response to SARS-CoV-2 infection provides a basis for further investigation of the importance of NK-like CD8+ T cells in COVID-19 severity.
- Published
- 2022
11. Dexamethasone sensitizes to ferroptosis by glucocorticoid receptor-induced dipeptidase-1 expression and glutathione depletion
- Author
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von Mässenhausen, Anne, Gonzalez, Nadia Zamora, Maremonti, Francesca, Belavgeni, Alexia, Tonnus, Wulf, Meyer, Claudia, Beer, Kristina, Hannani, Monica T., Lau, Arthur, Peitzsch, Mirko, Hoppenz, Paul, Locke, Sophie, Chavakis, Triantafyllos, Kramann, Rafael, Muruve, Daniel A., Hugo, Christian, Bornstein, Stefan R., Linkermann, Andreas, von Mässenhausen, Anne, Gonzalez, Nadia Zamora, Maremonti, Francesca, Belavgeni, Alexia, Tonnus, Wulf, Meyer, Claudia, Beer, Kristina, Hannani, Monica T., Lau, Arthur, Peitzsch, Mirko, Hoppenz, Paul, Locke, Sophie, Chavakis, Triantafyllos, Kramann, Rafael, Muruve, Daniel A., Hugo, Christian, Bornstein, Stefan R., and Linkermann, Andreas
- Abstract
Dexamethasone is widely used as an immunosuppressive therapy and recently as COVID-19 treatment. Here, we demonstrate that dexamethasone sensitizes to ferroptosis, a form of iron-catalyzed necrosis, previously suggested to contribute to diseases such as acute kidney injury, myocardial infarction, and stroke, all of which are triggered by glutathione (GSH) depletion. GSH levels were significantly decreased by dexamethasone. Mechanistically, we identified that dexamethasone up-regulated the GSH metabolism regulating protein dipeptidase-1 (DPEP1) in a glucocorticoid receptor (GR)-dependent manner. DPEP1 knockdown reversed the phenotype of dexamethasone-induced ferroptosis sensitization. Ferroptosis inhibitors, the DPEP1 inhibitor cilastatin, or genetic DPEP1 inactivation reversed the dexamethasone-induced increase in tubular necrosis in freshly isolated renal tubules. Our data indicate that dexamethasone sensitizes to ferroptosis by a GR-mediated increase in DPEP1 expression and GSH depletion. Together, we identified a previously unknown mechanism of glucocorticoid-mediated sensitization to ferroptosis bearing clinical and therapeutic implications.
- Published
- 2022
12. Spatial multi-omic map of human myocardial infarction
- Author
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Team Medisch, Circulatory Health, Regenerative Medicine and Stem Cells, Pathologie Pathologen staf, Kuppe, Christoph, Ramirez Flores, Ricardo O, Li, Zhijian, Hayat, Sikander, Levinson, Rebecca T, Liao, Xian, Hannani, Monica T, Tanevski, Jovan, Wünnemann, Florian, Nagai, James S, Halder, Maurice, Schumacher, David, Menzel, Sylvia, Schäfer, Gideon, Hoeft, Konrad, Cheng, Mingbo, Ziegler, Susanne, Zhang, Xiaoting, Peisker, Fabian, Kaesler, Nadine, Saritas, Turgay, Xu, Yaoxian, Kassner, Astrid, Gummert, Jan, Morshuis, Michiel, Amrute, Junedh, Veltrop, Rogier J A, Boor, Peter, Klingel, Karin, Van Laake, Linda W, Vink, Aryan, Hoogenboezem, Remco M, Bindels, Eric M J, Schurgers, Leon, Sattler, Susanne, Schapiro, Denis, Schneider, Rebekka K, Lavine, Kory, Milting, Hendrik, Costa, Ivan G, Saez-Rodriguez, Julio, Kramann, Rafael, Team Medisch, Circulatory Health, Regenerative Medicine and Stem Cells, Pathologie Pathologen staf, Kuppe, Christoph, Ramirez Flores, Ricardo O, Li, Zhijian, Hayat, Sikander, Levinson, Rebecca T, Liao, Xian, Hannani, Monica T, Tanevski, Jovan, Wünnemann, Florian, Nagai, James S, Halder, Maurice, Schumacher, David, Menzel, Sylvia, Schäfer, Gideon, Hoeft, Konrad, Cheng, Mingbo, Ziegler, Susanne, Zhang, Xiaoting, Peisker, Fabian, Kaesler, Nadine, Saritas, Turgay, Xu, Yaoxian, Kassner, Astrid, Gummert, Jan, Morshuis, Michiel, Amrute, Junedh, Veltrop, Rogier J A, Boor, Peter, Klingel, Karin, Van Laake, Linda W, Vink, Aryan, Hoogenboezem, Remco M, Bindels, Eric M J, Schurgers, Leon, Sattler, Susanne, Schapiro, Denis, Schneider, Rebekka K, Lavine, Kory, Milting, Hendrik, Costa, Ivan G, Saez-Rodriguez, Julio, and Kramann, Rafael
- Published
- 2022
13. Dexamethasone sensitizes to ferroptosis by glucocorticoid receptor-induced dipeptidase-1 expression and glutathione depletion
- Author
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von Mässenhausen, Anne; https://orcid.org/0000-0002-4727-782X, Zamora Gonzalez, Nadia, Maremonti, Francesca; https://orcid.org/0000-0002-7670-2055, Belavgeni, Alexia; https://orcid.org/0000-0001-6311-5858, Tonnus, Wulf; https://orcid.org/0000-0002-9728-1413, Meyer, Claudia; https://orcid.org/0000-0002-8722-0772, Beer, Kristina, Hannani, Monica T; https://orcid.org/0000-0002-4123-6832, Lau, Arthur; https://orcid.org/0000-0003-3545-6756, Peitzsch, Mirko, Hoppenz, Paul; https://orcid.org/0000-0003-3437-0619, Locke, Sophie, Chavakis, Triantafyllos, Kramann, Rafael; https://orcid.org/0000-0003-4048-6351, Muruve, Daniel A; https://orcid.org/0000-0003-1757-218X, Hugo, Christian; https://orcid.org/0000-0001-5895-3005, Bornstein, Stefan R; https://orcid.org/0000-0002-5211-2536, Linkermann, Andreas; https://orcid.org/0000-0001-6287-9725, von Mässenhausen, Anne; https://orcid.org/0000-0002-4727-782X, Zamora Gonzalez, Nadia, Maremonti, Francesca; https://orcid.org/0000-0002-7670-2055, Belavgeni, Alexia; https://orcid.org/0000-0001-6311-5858, Tonnus, Wulf; https://orcid.org/0000-0002-9728-1413, Meyer, Claudia; https://orcid.org/0000-0002-8722-0772, Beer, Kristina, Hannani, Monica T; https://orcid.org/0000-0002-4123-6832, Lau, Arthur; https://orcid.org/0000-0003-3545-6756, Peitzsch, Mirko, Hoppenz, Paul; https://orcid.org/0000-0003-3437-0619, Locke, Sophie, Chavakis, Triantafyllos, Kramann, Rafael; https://orcid.org/0000-0003-4048-6351, Muruve, Daniel A; https://orcid.org/0000-0003-1757-218X, Hugo, Christian; https://orcid.org/0000-0001-5895-3005, Bornstein, Stefan R; https://orcid.org/0000-0002-5211-2536, and Linkermann, Andreas; https://orcid.org/0000-0001-6287-9725
- Abstract
Dexamethasone is widely used as an immunosuppressive therapy and recently as COVID-19 treatment. Here, we demonstrate that dexamethasone sensitizes to ferroptosis, a form of iron-catalyzed necrosis, previously suggested to contribute to diseases such as acute kidney injury, myocardial infarction, and stroke, all of which are triggered by glutathione (GSH) depletion. GSH levels were significantly decreased by dexamethasone. Mechanistically, we identified that dexamethasone up-regulated the GSH metabolism regulating protein dipeptidase-1 (DPEP1) in a glucocorticoid receptor (GR)-dependent manner. DPEP1 knockdown reversed the phenotype of dexamethasone-induced ferroptosis sensitization. Ferroptosis inhibitors, the DPEP1 inhibitor cilastatin, or genetic DPEP1 inactivation reversed the dexamethasone-induced increase in tubular necrosis in freshly isolated renal tubules. Our data indicate that dexamethasone sensitizes to ferroptosis by a GR-mediated increase in DPEP1 expression and GSH depletion. Together, we identified a previously unknown mechanism of glucocorticoid-mediated sensitization to ferroptosis bearing clinical and therapeutic implications.
- Published
- 2022
14. 077 - LONGITUDINAL STABILITY OF MOLECULAR ENDOTYPES OF KNEE OSTEOARTHRITIS PATIENTS FROM THE APPROACH COHORT
- Author
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Hannani, Monica T., Thudium, Christian S., Gellhorn, Alfred C., Larkin, Jonathan, Ladel, Christoph, Bager, Cecilie, Karsdal, Morten, Struglics, André, Lafeber, Florian, Mastbergen, Simon, Uebelhoer, Melanie, Blanco-Garcia, Francisco J, Haugen, Ida K., Weinans, Harrie, Kloppenburg, Margreet, Berenbaum, Francis, Bacardit, Jaume, and Bay-Jensen, Anne C.
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- 2024
- Full Text
- View/download PDF
15. Dexamethasone sensitizes to ferroptosis by glucocorticoid receptor–induced dipeptidase-1 expression and glutathione depletion
- Author
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von Mässenhausen, Anne, primary, Zamora Gonzalez, Nadia, additional, Maremonti, Francesca, additional, Belavgeni, Alexia, additional, Tonnus, Wulf, additional, Meyer, Claudia, additional, Beer, Kristina, additional, Hannani, Monica T., additional, Lau, Arthur, additional, Peitzsch, Mirko, additional, Hoppenz, Paul, additional, Locke, Sophie, additional, Chavakis, Triantafyllos, additional, Kramann, Rafael, additional, Muruve, Daniel A., additional, Hugo, Christian, additional, Bornstein, Stefan R., additional, and Linkermann, Andreas, additional
- Published
- 2022
- Full Text
- View/download PDF
16. Non-Canonical Hedgehog Signaling Mediates Profibrotic Hematopoiesis-Stroma Crosstalk in Myeloproliferative Neoplasms
- Author
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Pritchard, Jessica E., Pearce, Juliette E., Snoeren, Inge A.M., Fuchs, Stijn N.R., Götz, Katrin, Peisker, Fabian, Wagner, Silke, Benabid, Adam, Lutterbach, Niklas, Klöker, Vanessa, Nagai, James S., Hannani, Monica T., Galyga, Anna K., Sistemich, Ellen, Banjanin, Bella, Flosdorf, Niclas, Bindels, Eric, Olschok, Kathrin, Biaesch, Katharina, Chatain, Nicolas, Bhagwat, Neha, Dunbar, Andrew, Sarkis, Rita, Naveiras, Olaia, Berres, Marie-Luise, Koschmieder, Steffen, Levine, Ross L., Costa, Ivan G., Gleitz, Hélène F.E., Kramann, Rafael, and Schneider, Rebekka K.
- Abstract
The role of hematopoietic hedgehog signaling in MPN remains incompletely understood despite data suggesting Hh pathway inhibitors have therapeutic activity in patients. We aim to systematically interrogate the role of canonical vs. non canonical Hh signaling in MPN. We show that Gli1 protein levels in patient PBMCs mark fibrotic progression and that in murine MPN models, absence of hematopoietic Gli1, but not Gli2or Smo, significantly reduces MPN phenotype and fibrosis, indicating that GLI1 in the MPN clone can be activated in a non-canonical fashion. Additionally, we establish that hematopoietic Gli1has a significant effect on stromal cells, mediated through a druggable MIF/CD74 axis. These data highlight the complex interplay between alterations in the MPN clone and activation of stromal cells and indicate Gli1represents a promising therapeutic target in MPN, particularly Hh signaling is dispensable for normal hematopoiesis.
- Published
- 2023
- Full Text
- View/download PDF
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