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2. The Reb1-homologue Ydr026c/Nsi1 is required for efficient RNA polymerase I termination in yeast

Author

Philipp Milkereit, Attila Németh, Joachim Griesenbeck, Olivier Gadal, Philipp Merkl, Stephan Hamperl, Alarich Reiter, Herbert Tschochner, Hannah Seitz, Lydia Williams, Jorge Perez-Fernandez, Jochen Gerber, and Isabelle Léger

Subjects
General Immunology and Microbiology, General transcription factor, biology, General Neuroscience, Termination factor, RNA polymerase II, Molecular biology, General Biochemistry, Genetics and Molecular Biology, Cell biology, Terminator (genetics), Transcription (biology), Antitermination, RNA polymerase I, biology.protein, Molecular Biology, RNA polymerase II holoenzyme
Abstract

Several DNA cis-elements and trans-acting factors were described to be involved in transcription termination and to release the elongating RNA polymerases from their templates. Different models for the molecular mechanism of transcription termination have been suggested for eukaryotic RNA polymerase I (Pol I) from results of in vitro and in vivo experiments. To analyse the molecular requirements for yeast RNA Pol I termination, an in vivo approach was used in which efficient termination resulted in growth inhibition. This led to the identification of a Myb-like protein, Ydr026c, as bona fide termination factor, now designated Nsi1 (NTS1 silencing protein 1), since it was very recently described as silencing factor of ribosomal DNA. Possible Nsi1 functions in regard to the mechanism of transcription termination are discussed.

Published
2012
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3. The Reb1-homologue Ydr026c/Nsi1 is required for efficient RNA polymerase I termination in yeast

Author

Alarich, Reiter, Stephan, Hamperl, Hannah, Seitz, Philipp, Merkl, Jorge, Perez-Fernandez, Lydia, Williams, Jochen, Gerber, Attila, Németh, Isabelle, Léger, Olivier, Gadal, Philipp, Milkereit, Joachim, Griesenbeck, and Herbert, Tschochner

Subjects
DNA-Binding Proteins, Saccharomyces cerevisiae Proteins, Sequence Homology, Amino Acid, Transcription, Genetic, RNA Polymerase I, Molecular Sequence Data, Amino Acid Sequence, Saccharomyces cerevisiae, Article
Abstract

Several DNA cis-elements and trans-acting factors were described to be involved in transcription termination and to release the elongating RNA polymerases from their templates. Different models for the molecular mechanism of transcription termination have been suggested for eukaryotic RNA polymerase I (Pol I) from results of in vitro and in vivo experiments. To analyse the molecular requirements for yeast RNA Pol I termination, an in vivo approach was used in which efficient termination resulted in growth inhibition. This led to the identification of a Myb-like protein, Ydr026c, as bona fide termination factor, now designated Nsi1 (NTS1 silencing protein 1), since it was very recently described as silencing factor of ribosomal DNA. Possible Nsi1 functions in regard to the mechanism of transcription termination are discussed.

Published
2012

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