Search

Your search keyword '"Hanna Blazel"' showing total 46 results
Start Over Author "Hanna Blazel"
46 results on '"Hanna Blazel"'

1. Latent Factor Structure and Measurement Invariance of the NIH Toolbox Cognition Battery in an Alzheimer’s Disease Research Sample

Author

Michelle L. Wahoske, Rick Chappell, Hanna Blazel, Sanjay Asthana, Yue Ma, Sterling C. Johnson, Cynthia M. Carlsson, and Carey E. Gleason

Subjects
030506 rehabilitation, Sample (statistics), NIH Toolbox, Neuropsychological Tests, Article, Alzheimer's disease research, Executive Function, 03 medical and health sciences, Cognition, 0302 clinical medicine, Alzheimer Disease, medicine, Humans, Dementia, Measurement invariance, General Neuroscience, medicine.disease, Exploratory factor analysis, Confirmatory factor analysis, Psychiatry and Mental health, Clinical Psychology, Neurology (clinical), Factor Analysis, Statistical, 0305 other medical science, Psychology, 030217 neurology & neurosurgery, Clinical psychology
Abstract

Objective:This study investigated the latent factor structure of the NIH Toolbox Cognition Battery (NIHTB-CB) and its measurement invariance across clinical diagnosis and key demographic variables including sex, race/ethnicity, age, and education for a typical Alzheimer’s disease (AD) research sample.Method:The NIHTB-CB iPad English version, consisting of 7 tests, was administered to 411 participants aged 45–94 with clinical diagnosis of cognitively unimpaired, dementia, mild cognitive impairment (MCI), or impaired not MCI. The factor structure of the whole sample was first examined with exploratory factor analysis (EFA) and further refined using confirmatory factor analysis (CFA). Two groups were classified for each variable (diagnosis or demographic factors). The confirmed factor model was next tested for each group with CFA. If the factor structure was the same between the groups, measurement invariance was then tested using a hierarchical series of nested two-group CFA models.Results:A two-factor model capturing fluid cognition (executive function, processing speed, and memory) versus crystalized cognition (language) fit well for the whole sample and each group except for those with age < 65. This model generally had measurement invariance across sex, race/ethnicity, and education, and partial invariance across diagnosis. For individuals with age < 65, the language factor remained intact while the fluid cognition was separated into two factors: (1) executive function/processing speed and (2) memory.Conclusions:The findings mostly supported the utility of the battery in AD research, yet revealed challenges in measuring memory for AD participants and longitudinal change in fluid cognition.

Published
2020

2. The U-ARE Protocol: A Pragmatic Approach to Decisional Capacity Assessment for Clinical Research

Author

Hanna Blazel, Cynthia H Phelan, Nickolas H. Lambrou, Sanjay Asthana, Nichelle Cobb, Mary F. Wyman, Carey E. Gleason, Amy J.H. Kind, Nathaniel A. Chin, and Rachel K. B. Hamilton

Subjects
0301 basic medicine, Gerontology, Process (engineering), media_common.quotation_subject, Decision Making, Population, Article, Ethics, Research, 03 medical and health sciences, 0302 clinical medicine, Clinical Protocols, Alzheimer Disease, Informed consent, medicine, Humans, Dementia, Mental Competency, education, Aged, media_common, Aged, 80 and over, Protocol (science), education.field_of_study, General Neuroscience, General Medicine, Middle Aged, medicine.disease, Psychiatry and Mental health, Clinical Psychology, 030104 developmental biology, Geriatrics and Gerontology, Psychology, Welfare, 030217 neurology & neurosurgery, Research center, Autonomy
Abstract

With increased longevity and growth in the number of older adults comes rising rates of individuals with cognitive impairment and dementia. The expansion of this population has important implications for research on aging and dementia syndromes, namely increased enrollment of older individuals in clinical research. Ethical prerogatives, as well as historical underrepresentation of persons with dementia in research studies due to the perceived burden of traditional decisional capacity evaluations, necessitates the development of pragmatic approaches to ascertain decisional abilities in research settings. We outline a protocol used in the Wisconsin Alzheimer’s Disease Research Center (ADRC) that adopts a stepped approach to the evaluation of decisional capacity meant to maximize study visit efficiency while preserving participant safety and autonomy. The protocol specifies the structure of the consent process and incorporates a brief semi-structured interview based on Appelbaum & Grisso’s theoretical model for evaluating a patient’s decisional capacity to provide informed consent to participate in research. This protocol is easily implemented in a research study visit and is designed to minimize participant burden and ensure reliable assessment of decisional capacity in older adults across a wide range of research protocols. The protocol emphasizes capacity optimization, using memory aids and other compensatory strategies to preserve participant autonomy while protecting welfare.

Published
2020

3. The influence of race on intraprocedural complication and side effect rates of lumbar punctures

Author

Allison C. Eierman, Aleshia Cole, Carol A. Van Hulle, Yue Ma, Karen K. Lazar, Cynthia M. Carlsson, Nathaniel A. Chin, Sanjay Asthana, Hanna Blazel, Barbara B. Bendlin, Ozioma C. Okonkwo, Dorothy Farrar Edwards, Michelle L. Wahoske, Sterling C. Johnson, and Carey E. Gleason

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2021

4. Greater COVID‐19 impact for underrepresented racial and ethnic minority groups: A survey study on the Wisconsin Alzheimer’s Disease Research Center participants

Author

Yue Ma, Alice Spalitta, Michelle L Wahoske, Hanna Blazel, Richard J Chappell, Nathaniel A Chin, Sterling C Johnson, Sanjay Asthana, Carey E Gleason, and Cynthia M Carlsson

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2021

6. A qualitative analysis of study participant and study partner experiences with the consent process: Assessments guiding the development of an electronic consent (ECONSENT)

Author

Megan Doerr, Jennifer Dykema, Cecelia Manzanares, Dorothy F. Edwards, Erin Chin, Jennifer Hamann, Felicia C. Goldstein, Amy Truong, Kenneth D. Croes, James J. Lah, Hanna Blazel, and Christine Suver

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Medical education, Qualitative analysis, Developmental Neuroscience, Epidemiology, Process (engineering), Health Policy, Research participant, Neurology (clinical), Geriatrics and Gerontology, Psychology
Published
2020

7. Factors Associated with Lumbar Puncture Participation in Alzheimer's Disease Research

Author

Carol A. Van Hulle, Dorothy F. Edwards, Chuck Illingworth, Alice Spalitta, Hanna Blazel, Sterling C. Johnson, Aleshia Cole, Carey E. Gleason, Yue Ma, Cynthia M. Carlsson, Michelle L. Wahoske, Karen K. Lazar, Barbara B. Bendlin, Nancy J. Davenport-Sis, Sanjay Asthana, and Madeleine Blazel

Subjects
Adult, Male, medicine.medical_specialty, Biomedical Research, Ethnic group, Disease, Spinal Puncture, Lumbar, Alzheimer Disease, Internal medicine, medicine, Dementia, Humans, lumbar puncture, Longitudinal Studies, Adverse effect, Aged, Aged, 80 and over, medicine.diagnostic_test, Lumbar puncture, business.industry, General Neuroscience, Cognition, General Medicine, Middle Aged, research subject recruitment, medicine.disease, Psychiatry and Mental health, Clinical Psychology, Female, Geriatrics and Gerontology, Patient Participation, community participation, business, Body mass index, Biomarkers, Follow-Up Studies, Research Article
Abstract

Background: Cerebrospinal fluid (CSF) provides insight into the spectrum of Alzheimer’s disease (AD) pathology. While lumbar punctures (LPs) for CSF collection are generally considered safe procedures, many participants remain hesitant to participate in research involving LPs. Objective: To explore factors associated with participant willingness to undergo a research LP at baseline and follow-up research study visit. Methods: We analyzed data from 700 participants with varying cognition (unimpaired, mild cognitive impairment, and dementia) in the Wisconsin Alzheimer’s Disease Research Center. We evaluated the relationship of demographic variables (age, sex, race, ethnicity, and years of education) and clinical variables (waist-to-hip ratio, body mass index, AD parental history, cognitive diagnosis) on decision to undergo baseline LP1. We evaluated the relationship of prior LP1 experience (procedure success and adverse events) with the decision to undergo follow-up LP2. The strongest predictors were incorporated into regression models. Results: Over half of eligible participants opted into both baseline and follow-up LP. Participants who underwent LP1 had higher mean education than those who declined (p = 0.020). White participants were more likely to choose to undergo LP1 (p

Published
2020

8. Informed Consent in Two Alzheimer’s Disease Research Centers: Insights from Research Coordinators

Author

Hanna Blazel, Lara M. Mangravite, Megan Doerr, James J. Lah, Dorothy F. Edwards, Felicia C. Goldstein, Christine M. Suver, Allan I. Levey, Cecelia Manzanares, Erin M. Chin, Sanjay Asthana, and Jennifer Hamann

Subjects
Adult, Male, Therapeutic Misconception, Vocabulary, Health (social science), Biomedical Research, Research Subjects, media_common.quotation_subject, Grounded theory, Article, Ethics, Research, Consent Forms, Informed consent, Alzheimer Disease, Surveys and Questionnaires, Agency (sociology), Humans, Attention, Misinformation, Study Coordinator, Qualitative Research, media_common, Medical education, Informed Consent, Health Policy, Communication, Cognition, Professional-Patient Relations, Research Personnel, Philosophy, Female, Psychology, Comprehension, Qualitative research
Abstract

Background: Informed consent (IC) is critical to performing ethical research. Unfortunately, the IC process and supporting IC forms are frequently burdensome and do not necessarily meet the informational needs of participants. The intersecting legal and ethical challenges of obtaining IC from individuals with memory or cognitive deficits further exacerbate existing IC shortcomings. For this reason, study coordinators play a critical role in facilitating the IC process in Alzheimer's disease (AD) research. To identify opportunities to improve how IC is obtained in AD research, we examined the IC process from the perspectives of study coordinators at two Alzheimer's Disease Research Centers (ADRC). Methods: We performed semi-structured interviews with 15 study coordinators from two ADRC sites detailing their experience obtaining IC. Interviews were conducted in private, recorded, transcribed, and independently coded using the constant comparative method of grounded theory. Key themes were explored as they emerged. Results: Coordinators reported overall satisfaction with the IC process. However, many reported difficulties maintaining participant attention, explaining complex procedures, and addressing medical misinformation. Although the centers use site-specific consent forms, coordinators at both centers stressed that their IC is too long and the supporting IC forms are too complicated. Coordinators indicated modifying the IC process to the perceived needs of individual participants. Adaptations reported include altering the cadence and vocabulary they employ, using supplemental materials, varying the order of IC topics, and limiting the depth of information presented. Conclusion: A qualitative analysis of interviews with study coordinators reveals opportunities to improve how we obtain IC in AD research. These insights will be used to create an electronic informed consent (eConsent) designed to boost engagement, enhance trust, and improve understanding by supporting participants' direct agency in the IC process.

Published
2020

9. TD‐03‐03: DEVELOPING AN ELECTRONIC CONSENT FOR ADRC

Author

Kenneth D. Croes, James J. Lah, Allan I. Levey, Woody MacDuffie, Felicia C. Goldstein, Nichelle Cobb, Cecelia Manzanares, Dorothy F. Edwards, Jennifer Dykema, Stockard Simon, Hanna Blazel, John Wilbanks, Christine Suver, Sanjay Asthana, Erin Chin, Allie Seroussi, Carey E. Gleason, and Lara M. Mangravite

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2019

10. P4‐282: DEMOGRAPHIC FACTORS INFLUENCE PARTICIPATION IN LUMBAR PUNCTURES

Author

Sterling C. Johnson, Aleshia Cole, Carol A. Van Hulle, Chuck Illingworth, Nancy J. Davenport, Sanjay Asthana, Cynthia M. Carlsson, Karen K. Lazar, Alice Spalitta, Madeleine Blazel, Michelle L. Wahoske, and Hanna Blazel

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, medicine.medical_specialty, Lumbar, Developmental Neuroscience, Epidemiology, business.industry, Health Policy, Physical therapy, Medicine, Neurology (clinical), Geriatrics and Gerontology, business
Published
2018

11. P4‐305: IMPACT OF SIMVASTATIN ON CEREBRAL BLOOD FLOW, PULSATILITY INDEX, AND ALZHEIMER'S DISEASE BIOMARKERS: A CLINICAL TRIAL

Author

Sterling C. Johnson, Chuck Illingworth, Maritza Dowling, Carson Hoffman, Rick Chappell, Patrick A. Turski, Barbara B. Bendlin, Henrik Zettenberg, Natanya S. Russek, Sanjay Asthana, Cynthia M. Carlsson, Benjamin P. Austin, Yue Ma, Oliver Wieben, Jennifer M. Oh, Karen K. Lazar, Howard A. Rowley, Leonardo A. Rivera, Laura E. Jacobson, Carey E. Gleason, Kaj Blennow, Lindsay R. Clark, Sara E. Berman, and Hanna Blazel

Subjects
medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Alzheimer's disease biomarkers, Pulsatility index, Clinical trial, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Cerebral blood flow, Simvastatin, Internal medicine, Cardiology, Medicine, Neurology (clinical), Geriatrics and Gerontology, business, medicine.drug
Published
2018

12. P4‐304: RELATIONSHIP BETWEEN AORTIC AUGMENTATION INDEX BY RADIAL ARTERY TONOMETRY AND CEREBRAL PULSATILITY INDEX IN INDIVIDUALS AT RISK FOR ALZHEIMER'S DISEASE

Author

Rick Chappell, Chuck Illingworth, Cynthia M. Carlsson, Yue Ma, Hanna Blazel, Claudia E. Korcarz, Patrick A. Turski, Natanya S. Russek, Adam D. Gepner, Sterling C. Johnson, Karen K. Lazar, Barbara B. Bendlin, Oliver Wieben, James H. Stein, Leonardo A. Rivera, Laura E. Jacobson, Benjamin P. Austin, Jennifer M. Oh, Sara E. Berman, Carson Hoffman, Carey E. Gleason, Lindsay R. Clark, and Sanjay Asthana

Subjects
medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Disease, Aortic Augmentation Index, Pulsatility index, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Internal medicine, medicine.artery, Cardiology, Medicine, Neurology (clinical), Geriatrics and Gerontology, Radial artery, business
Published
2018

13. P3‐271: LUMBAR PUNCTURE SIDE EFFECT RATES IN A RESEARCH SETTING

Author

Carey E. Gleason, Lindsay R. Clark, Sterling C. Johnson, Aleshia Cole, Cynthia M. Carlsson, Michelle L. Wahoske, Ozioma C. Okonkwo, Sanjay Asthana, Nathaniel A. Chin, Karen K. Lazar, Dorothy F. Edwards, Barbara B. Bendlin, Carol A. Van Hulle, Madeleine Blazel, and Hanna Blazel

Subjects
0301 basic medicine, medicine.medical_specialty, medicine.diagnostic_test, Side effect, Epidemiology, business.industry, Lumbar puncture, Health Policy, Surgery, 03 medical and health sciences, Psychiatry and Mental health, Cellular and Molecular Neuroscience, 030104 developmental biology, 0302 clinical medicine, Developmental Neuroscience, Medicine, Neurology (clinical), Geriatrics and Gerontology, business, Research setting, 030217 neurology & neurosurgery
Published
2018

14. P2‐524: KEY ELEMENTS SUPPORTING RECRUITMENT AND RETENTION OF UNDERREPRESENTED GROUPS INTO RESEARCH: OUR EXPERIENCE IN THE AFRICAN AMERICAN COMMUNITY

Author

Fabu P. Carter, Sterling C. Johnson, Gina Green-Harris, Dorothy F. Edwards, Carey E. Gleason, Susan Flowers Benton, Tierra Smith, Cynthia M. Carlsson, John Lucille, Hanna Blazel, and Brieanna L. Harris

Subjects
African american, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Political science, Key (cryptography), Gender studies, Neurology (clinical), Geriatrics and Gerontology
Published
2018

15. P1‐248: LATENT PROFILES DERIVED FROM ATN RELATED CSF BIOMARKERS

Author

Carey E. Gleason, Rick Chappell, Lindsay R. Clark, Henrik Zetterberg, Laura H. Jacobson, Barbara B. Bendlin, Carol A. Van Hulle, Sanjay Asthana, Hanna Blazel, Karen K. Lazar, Yue Ma, Cynthia M. Carlsson, Sterling C. Johnson, Aleshia Cole, Ozioma C. Okonkwo, and Kaj Blennow

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Csf biomarkers, Immunology, Neurology (clinical), Geriatrics and Gerontology
Published
2018

16. P4-247: ASSOCIATION OF CARDIOVASCULAR RISK AND SUBJECTIVE MEMORY COMPLAINTS IN HEALTHY MIDDLE AGED ADULTS

Author

Carey E. Gleason, Carol A. Van Hulle, Sterling C. Johnson, Lindsay R. Clark, Ozioma C. Okonkwo, Derek Norton, Sanjay Asthana, Barbara B. Bendlin, Hanna Blazel, Cynthia M. Carlsson, and Jack F.V. Hunt

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, business.industry, Health Policy, Medicine, Neurology (clinical), Subjective memory, Geriatrics and Gerontology, business, Association (psychology), Clinical psychology
Published
2019

17. P4-347: CARDIAC WORKLOAD IS ASSOCIATED WITH CSF BIOMARKERS IN COGNITIVELY NORMAL LATE-MIDDLE-AGED ADULTS AT RISK FOR ALZHEIMER'S DISEASE

Author

Sterling C. Johnson, Henrik Zetterberg, Ozioma C. Okonkwo, Hanna Blazel, Cynthia M. Carlsson, Kaj Blennow, Barbara B. Bendlin, Sanjay Asthana, Yue Ma, Catherine L. Gallagher, and Sarah Lose

Subjects
medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Workload, Disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Internal medicine, Csf biomarkers, medicine, Neurology (clinical), Geriatrics and Gerontology, business
Published
2019

18. P4-557: SEX-BASED DIFFERENCES IN DEPRESSION IN INDIVIDUALS WITH MILD COGNITIVE IMPAIRMENT OR DEMENTIA COMPARED TO COGNITIVELY UNIMPAIRED OLDER ADULTS

Author

Sterling C. Johnson, Hanna Blazel, Cynthia M. Carlsson, Sanjay Asthana, Carol A. Van Hulle, Madeleine Blazel, Carey E. Gleason, Barbara B. Bendlin, and Karen K. Lazar

Subjects
Epidemiology, business.industry, Health Policy, medicine.disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Medicine, Dementia, Neurology (clinical), Geriatrics and Gerontology, business, Cognitive impairment, Depression (differential diagnoses), Clinical psychology
Published
2019

19. [P1–526]: THE WRAP‐AROUND APPROACH: A NOVEL RENTENTION STRATEGY IN THE AA‐FAIM STUDY

Author

Hanna Blazel, Sterling C. Johnson, Carey E. Gleason, Brieanna L. Harris, Nia Norris, Stephanie Houston, Dorothy F. Edwards, Gina Green-Harris, Fabu P. Carter, and Sanjay Asthana

Subjects
Epidemiology, Health Policy, 03 medical and health sciences, Psychiatry and Mental health, Cellular and Molecular Neuroscience, 0302 clinical medicine, Developmental Neuroscience, Computer architecture, Wrap around, 030212 general & internal medicine, Neurology (clinical), Geriatrics and Gerontology, Psychology, 030217 neurology & neurosurgery
Published
2017

21. [P4–301]: COMPARING COGNITIVE BATTERIES: UNIFORM DATA SET 2 (UDS‐2) AND UNIFORM DATA SET 3 (UDS‐3) IN NON‐HISPANIC WHITE PARTICIPANTS AND THOSE FROM UNDERREPRESENTED GROUPS ENROLLED IN THE WISCONSIN ALZHEIMER'S DISEASE RESEARCH CENTER'S CLINICAL CORE

Author

Rick Chappell, Colin A. Longhurst, Sanjay Asthana, Michelle L. Wahoske, Naomi C. Holt, Sterling C. Johnson, Mary F. Wyman, Carey E. Gleason, Hanna Blazel, and Cynthia M. Carlsson

Subjects
Gerontology, Epidemiology, business.industry, Health Policy, Cognition, Data set, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Medicine, Center (algebra and category theory), Neurology (clinical), Geriatrics and Gerontology, business, Clinical psychology
Published
2017

22. [O5–01–05]: COHORT AND RACE DIFFERENCES IN FACTORS ASSOCIATED WITH ATTRITION IN LONGITUDINAL STUDIES OF ALZHEIMER's DISEASE

Author

Dorothy F. Edwards, Carey E. Gleason, Sanjay Asthana, Cynthia M. Carlsson, Hanna Blazel, Susan Stark, and Alice Spalitta

Subjects
030214 geriatrics, Epidemiology, business.industry, Health Policy, Disease, medicine.disease, 03 medical and health sciences, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Race (biology), 0302 clinical medicine, Developmental Neuroscience, Cohort, medicine, Attrition, Neurology (clinical), Geriatrics and Gerontology, business, Demography
Published
2017

23. Cerebrospinal fluid sphingolipids, β-amyloid, and tau in adults at risk for Alzheimer's disease

Author

Sterling C. Johnson, Carey E. Gleason, Sanjay Asthana, Norman J. Haughey, Mark A. Sager, Hanna Blazel, Kaj Blennow, Veera Venkata Ratnam Bandaru, Cynthia M. Carlsson, Henrik Zetterberg, Ulf Andreasson, Luigi Puglielli, and Michelle M. Mielke

Subjects
Adult, Male, Risk, Apolipoprotein E, Aging, medicine.medical_specialty, Ceramide, Genotype, tau Proteins, Ceramides, Article, Pathogenesis, chemistry.chemical_compound, Apolipoproteins E, Cognition, Cerebrospinal fluid, Alzheimer Disease, In vivo, Internal medicine, Humans, Medicine, Aged, Amyloid beta-Peptides, business.industry, General Neuroscience, Middle Aged, medicine.disease, Sphingolipid, Sphingomyelins, Endocrinology, chemistry, Immunology, Female, Neurology (clinical), Geriatrics and Gerontology, Alzheimer's disease, business, Sphingomyelin, Developmental Biology
Abstract

Cellular studies suggest sphingolipids may cause or accelerate amyloid-beta (Aβ) and tau pathology but in vivo human studies are lacking. We determined cerebrospinal fluid levels of sphingolipids (ceramides and sphingomyelins), amyloid-beta (Aβ1-42, AβX-38, AβX-40, and AβX-42) and tau (T-tau and p-tau181) in 91 cognitively normal individuals, aged 36-69 years, with a parental history of Alzheimer's disease. The 18-carbon acyl chain length ceramide species was associated with AβX-38 (r = 0.312, p = 0.003), AβX-40 (r = 0.327, p = 0.002), and T-tau (r = 0.313, p = 0.003) but not with AβX-42 (r = 0.171, p = 0.106) or p-tau (r = 0.086, p = 0.418). All sphingomyelin species correlated (most p < 0.001) with all Aβ species and T-tau; many also correlated with p-tau. Results remained in regression models after controlling for age and APOE genotype. These results suggest in vivo relationships between cerebrospinal fluid ceramides and sphingomyelins and Aβ and tau levels in cognitively normal individuals at increased risk for Alzheimer's disease, indicating these sphingolipids may be associated with early pathogenesis.

Published
2014

24. P3-504: A QUALITATIVE ANALYSIS OF COORDINATOR PERCEPTIONS OF THE CONSENT PROCESS: LESSONS GUIDING THE DEVELOPMENT OF AN ELECTRONIC CONSENT PLATFORM

Author

Megan Doerr, Erin Chin, Hanna Blazel, Amy Truong, Christine Suver, Dayne Legreid, Dorothy F. Edwards, James J. Lah, Felicia C. Goldstein, Jennifer Hamann, and Cecelia Manzanares

Subjects
Medical education, Epidemiology, Process (engineering), Health Policy, media_common.quotation_subject, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Qualitative analysis, Developmental Neuroscience, Perception, Neurology (clinical), Geriatrics and Gerontology, Psychology, media_common
Published
2019

25. P2‐118: CEREBROSPINAL FLUID MICROGLIAL MARKERS IN ALZHEIMER'S DISEASE, MCI, AND ASYMPTOMATIC ADULTS

Author

Kaj Blennow, Margarete A. Wichmann, Laura E. Jacobson, Hanna Blazel, Barbara B. Bendlin, Sterling C. Johnson, Sanjay Asthana, Benjamin P. Austin, Ozioma C. Okonkwo, N. Maritza Dowling, Henrik Zetterberg, Carey E. Gleason, Cynthia M. Carlsson, and Rick Chappell

Subjects
Pathology, medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Disease, Asymptomatic, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Cerebrospinal fluid, Developmental Neuroscience, medicine, Neurology (clinical), Geriatrics and Gerontology, medicine.symptom, business
Published
2014

26. P2‐106: CSF BIOMARKER PROFILES IN MIDDLE‐AGED ADULTS WITH PARENTAL HISTORY OF AD: THE WISCONSIN ADRC COHORTS

Author

Laura E. Jacobson, Cynthia M. Carlsson, Hanna Blazel, Mark A. Sager, Sterling C. Johnson, Benjamin P. Austin, Sanjay Asthana, Rick Chappell, Barbara B. Bendlin, Ozioma C. Okonkwo, Kaj Blennow, Henrik Zetterberg, Margarete A. Wichmann, Maritza Dowling, and Carey E. Gleason

Subjects
Oncology, Gerontology, medicine.medical_specialty, Epidemiology, Health Policy, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Internal medicine, Csf biomarkers, medicine, Neurology (clinical), Geriatrics and Gerontology, Psychology
Published
2014

27. IC‐P‐102: THE RELATIONSHIP BETWEEN CEREBRAL PERFUSION, AGE, AND APOE4 IN MIDDLE‐AGED ADULTS AT RISK FOR ALZHEIMER'S DISEASE

Author

Rick Chappell, Mark A. Sager, Benjamin P. Austin, Sterling C. Johnson, Laura E. Jacobson, Cynthia M. Carlsson, Ozioma C. Okonkwo, N. Maritza Dowling, Carey E. Gleason, Jennifer M. Oh, Howard A. Rowley, Sanjay Asthana, Barbara B. Bendlin, and Hanna Blazel

Subjects
medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Internal medicine, Cardiology, Medicine, Neurology (clinical), Geriatrics and Gerontology, Cerebral perfusion pressure, business
Published
2014

28. P1‐229: THE RELATIONSHIP BETWEEN CEREBRAL PERFUSION, AGE, AND APOE4 IN MIDDLE‐AGED ADULTS AT RISK FOR ALZHEIMER'S DISEASE

Author

Benjamin Piya Austin, Sterling Johnson, Jennifer Oh, Barbara B. Bendlin, Carey Elizabeth Gleason, Ozioma Okonkwo, Laura E. Jacobson, Hanna Blazel, Rick Chappell, N. Maritza Dowling, Howard Rowley, Mark A. Sager, Sanjay Asthana, and Cynthia M. Carlsson

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2014

29. P1–186: The relationship of cerebral perfusion with age and CSF measures in middle‐aged adults at risk for Alzheimer's disease

Author

Benjamin Austin, Barbara Bendlin, Sterling Johnson, Henrik Zetterberg, Kaj Blennow, Hanna Blazel, Jodi Barnet, Maritza Dowling, Luigi Puglielli, Carey Gleason, Mark Sager, Sanjay Asthana, and Cynthia Carlsson

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2013

30. IC‐P‐095: The relationship of cerebral perfusion with age and CSF measures in middle‐aged adults at risk for Alzheimer's disease

Author

Kaj Blennow, Barbara B. Bendlin, Jodi H. Barnet, Carey E. Gleason, Mark A. Sager, Sanjay Asthana, Cynthia M. Carlsson, Henrik Zetterberg, Maritza Dowling, Benjamin P. Austin, Hanna Blazel, Luigi Puglielli, and Sterling C. Johnson

Subjects
medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Internal medicine, Cardiology, medicine, Neurology (clinical), Geriatrics and Gerontology, Cerebral perfusion pressure, business
Published
2013

31. P3–311: Baseline lipid levels predict cerebral blood flow response to statin therapy in middle‐aged adults at risk for Alzheimer's disease

Author

Jodi H. Barnet, Carey E. Gleason, Mark A. Sager, Barbara B. Bendlin, N. Maritza Dowling, Sanjay Asthana, Hanna Blazel, Sterling C. Johnson, Benjamin P. Austin, and Cynthia M. Carlsson

Subjects
medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Cerebral blood flow, Internal medicine, medicine, Cardiology, Physical therapy, Neurology (clinical), Statin therapy, Geriatrics and Gerontology, Baseline (configuration management), business
Published
2013

32. DT‐01–01: White matter cerebral blood flow is diminished in asymptomatic middle‐aged adults with maternal history of Alzheimer's disease

Author

Carey E. Gleason, Cynthia M. Carlsson, Howard A. Rowley, Sterling C. Johnson, Hanna Blazel, Laura H. Jacobson, Sanjay Asthana, Mark A. Sager, Ozioma C. Okonkwo, Barbara B. Bendlin, and Benjamin P. Austin

Subjects
Pathology, medicine.medical_specialty, Maternal history, Epidemiology, business.industry, Health Policy, Physiology, Disease, Asymptomatic, White matter, Psychiatry and Mental health, Cellular and Molecular Neuroscience, medicine.anatomical_structure, Developmental Neuroscience, Cerebral blood flow, medicine, Neurology (clinical), Geriatrics and Gerontology, medicine.symptom, business
Published
2013

33. P1–139: CSF sphingolipid levels correlate with CSF beta‐amyloid and tau

Author

Sanjay Asthana, Hanna Blazel, Veera Vankata Ratnam Bandaru, Henrik Zetterberg, Mark A. Sager, Norman J. Haughey, Sterling C. Johnson, Cynthia M. Carlsson, Luigi Puglielli, Carey E. Gleason, and Michelle M. Mielke

Subjects
medicine.medical_specialty, Amyloid, Epidemiology, Chemistry, Health Policy, Sphingolipid, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Endocrinology, Developmental Neuroscience, Internal medicine, medicine, Neurology (clinical), Geriatrics and Gerontology, Beta (finance)
Published
2013

34. IC‐P‐071: The relationship of deep white matter hyperintensity lesion size with perfusion and cognition in middle‐aged adults at risk for Alzheimer's disease

Author

Benjamin P. Austin, Yin Huang, Sean B. Fain, Guofan Xu, Hanna Blazel, Nayanjyoti Pathak, Laura H. Jacobson, Carey E. Gleason, Barbara B. Bendlin, Vikas Singh, Cynthia M. Carlsson, Erik K. Kastman, Howard A. Rowley, Sanjay Asthana, and Sterling C. Johnson

Subjects
medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Cognition, Disease, Hyperintensity, Lesion, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, White matter hyperintensity, Internal medicine, medicine, Cardiology, Neurology (clinical), Geriatrics and Gerontology, medicine.symptom, business, Perfusion
Published
2012

35. P3‐163: The relationship of deep white matter hyperintensity lesion size with perfusion and cognition in middle‐aged adults at risk for Alzheimer's disease

Author

Benjamin Austin, Erik Kastman, Yin Huang, Guofan Xu, Nayanjyoti Pathak, Vikas Singh, Sean Fain, Sanjay Asthana, Carey Gleason, Laura Jacobson, Hanna Blazel, Howard Rowley, Barbara Bendlin, Sterling Johnson, and Cynthia Carlsson

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2012

36. P4‐380: What are key factors that promote continued participation in Alzheimer's disease prevention studies?

Author

Sterling C. Johnson, Kara Paterson, Sanjay Asthana, Carey E. Gleason, Hanna Blazel, Laura E. Jacobson, Mark A. Sager, and Cynthia M. Carlsson

Subjects
Gerontology, medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Key factors, Developmental Neuroscience, Physical therapy, Medicine, Disease prevention, Neurology (clinical), Geriatrics and Gerontology, business
Published
2011

37. P4‐012: The Influence of Metabolic Syndrome on Simvastatin Therapy In Asymptomatic Adults at Risk for Alzheimer's Disease: The ESPRIT Study

Author

Jodi H. Barnet, Sterling C. Johnson, Sanjay Asthana, Henrik Zetterberg, Laura L. Miller, Bruce P. Hermann, Mark A. Sager, Luigi Puglielli, N. Maritza Dowling, Kaj Blennow, Cynthia M. Carlsson, Carey E. Gleason, Alyce J. Marsh, Craig S. Atwood, and Hanna Blazel

Subjects
medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Disease, medicine.disease, Asymptomatic, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Endocrinology, Developmental Neuroscience, Simvastatin, Internal medicine, medicine, Neurology (clinical), Geriatrics and Gerontology, medicine.symptom, Metabolic syndrome, business, medicine.drug
Published
2010

38. O4‐01‐06: A randomized, double‐blind placebo‐controlled trial of simvastatin on CSF, MRI, and cognitive biomarkers in middle‐aged adults at risk for Alzheimer's disease: The ESPRIT Study

Author

Carey E. Gleason, Mark A. Sager, Guofan Xu, Sean B. Fain, Sterling C. Johnson, Sanjay Asthana, Henrik Zetterberg, Jodi H. Barnet, Howard A. Rowley, Luigi Puglielli, Cynthia M. Carlsson, Craig S. Atwood, Hanna Blazel, George C. Newman, Bruce P. Hermann, Kaj Blennow, Yin Huang, and N. Maritza Dowling

Subjects
medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Placebo-controlled study, Cognition, Disease, Double blind, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Simvastatin, Internal medicine, medicine, Physical therapy, Neurology (clinical), Geriatrics and Gerontology, business, medicine.drug
Published
2010

39. P1‐451: Mid‐life dementia risk scores as a predictor of CSF biomarker response to simvastatin therapy in asymptomatic adults at risk for Alzheimer's disease: The ESPRIT study

Author

Sanjay Asthana, Bruce P. Hermann, N. Maritza Dowling, Henrik Zetterberg, Craig S. Atwood, Carey E. Gleason, Jodi H. Barnet, Sterling C. Johnson, Cynthia M. Carlsson, Alyce J. Marsh, Luigi Puglielli, Mark A. Sager, Hanna Blazel, and Kaj Blennow

Subjects
medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Disease, medicine.disease, Asymptomatic, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Simvastatin, Internal medicine, Csf biomarkers, medicine, Physical therapy, Dementia, Neurology (clinical), Geriatrics and Gerontology, medicine.symptom, business, medicine.drug
Published
2010

40. P3‐155: Assessing the capacity of patients with dementia to provide informed consent to participate in research: How important is memory?

Author

Jane F. Sachs, Tamara S. Markgraf, Jacqueline Lee, Zachary Zugin, Cynthia M. Carlsson, Carey E. Gleason, Sanjay Asthana, and Hanna Blazel

Subjects
medicine.medical_specialty, Epidemiology, Health Policy, medicine.disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Informed consent, medicine, Dementia, Neurology (clinical), Geriatrics and Gerontology, Psychiatry, Psychology
Published
2010

41. P1‐008: Gender differences in cognitive performance and response to simvastatin in adults at risk for Alzheimer's disease: (The ESPRIT Study)

Author

Carey E. Gleason, Cynthia M. Carlsson, Bruce P. Hermann, Laura E. Jacobson, Jodi H. Barnet, N.M. Dowling, Sterling C. Johnson, Sanjay Asthana, Mark A. Sager, and Hanna Blazel

Subjects
Epidemiology, Health Policy, Disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Simvastatin, medicine, Neurology (clinical), Effects of sleep deprivation on cognitive performance, Geriatrics and Gerontology, Psychology, Clinical psychology, medicine.drug
Published
2010

42. P3‐199: Relationship between CSF biomarkers and language fluency in asymptomatic middle‐aged adults at increased risk for Alzheimer's disease: The ESPRIT study

Author

Cynthia M. Carlsson, Alyce J. Marsh, Jodi H. Barnet, Sanjay Asthana, Henrik Zetterberg, Carey E. Gleason, Bruce P. Hermann, Mark A. Sager, Kaj Blennow, N. Maritza Dowling, Sterling C. Johnson, Craig S. Atwood, Hanna Blazel, and Luigi Puglielli

Subjects
Pediatrics, medicine.medical_specialty, Epidemiology, Health Policy, Disease, Asymptomatic, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Increased risk, Developmental Neuroscience, Language fluency, Csf biomarkers, medicine, Physical therapy, Neurology (clinical), Geriatrics and Gerontology, medicine.symptom, Psychology
Published
2010

43. P2‐276: Lumbar puncture procedures are not a barrier to recruitment into clinical trials for Alzheimer's disease prevention

Author

Sanjay Asthana, Cynthia M. Carlsson, Mark A. Sager, Lynn Gilbertson, and Hanna Blazel

Subjects
medicine.medical_specialty, medicine.diagnostic_test, Epidemiology, business.industry, Lumbar puncture, Health Policy, Surgery, Clinical trial, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Anesthesia, Medicine, Disease prevention, Neurology (clinical), Geriatrics and Gerontology, business
Published
2008

44. Effects of simvastatin on cerebrospinal fluid biomarkers and cognition in middle-aged adults at risk for Alzheimer's disease

Author

Carey E. Gleason, Hanna Blazel, Nathan T.N. Schreiber, Timothy Hess, Cynthia M. Carlsson, Rebecca L. Koscik, Sterling C. Johnson, Craig S. Atwood, James H. Stein, Mark A. Sager, Patrick E. McBride, Kimberly A. Moreland, Bruce P. Hermann, Sanjay Asthana, and Luigi Puglielli

Subjects
Oncology, Adult, Male, medicine.medical_specialty, Simvastatin, Lipoproteins, Apolipoprotein E4, Disease, Neuropsychological Tests, Placebo, Asymptomatic, Severity of Illness Index, Cerebrospinal fluid, Double-Blind Method, Alzheimer Disease, Risk Factors, Internal medicine, medicine, Verbal fluency test, Humans, Genetic Predisposition to Disease, Aged, Amyloid beta-Peptides, Working memory, General Neuroscience, Anticholesteremic Agents, Cognition, General Medicine, Middle Aged, Psychiatry and Mental health, Clinical Psychology, Physical therapy, Female, Geriatrics and Gerontology, medicine.symptom, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Psychology, Cognition Disorders, medicine.drug
Abstract

Background: Statins reduce amyloid-β (Aβ) levels in the brain and cerebrospinal fluid (CSF) in animals and may thereby favorably alter the pathobiology of AD. It is unclear if statins modify Aβ metabolism or improve cognition in asymptomatic middle-aged adults at increased risk for AD. Methods: In a 4-month randomized, double-blind, controlled study, we evaluated the effects of simvastatin 40 mg daily vs. placebo on CSF Aβ42 levels and cognition in 57 asymptomatic middle-aged adult children of persons with AD. Results: Compared to placebo, individuals randomized to simvastatin for 4 months had similar changes in CSF Aβ42 (p = 0.344) and total tau levels (p = 0.226), yet greater improvements in some measures of verbal fluency ( p = 0.024) and working memory (p = 0.015). APOE4 genotype, gender, and vascular risk factors were associated with CSF biomarker levels, but did not modify treatment effects. Conclusion: In asymptomatic middle-aged adults at increased risk for AD, simvastatin use improved selected measures of cognitive function without significantly changing CSF A β42 or total tau levels. Further studies are needed to clarify the impact of higher dose and/or longer duration statin therapy on not only Aβ metabolism, but also other preclinical processes related to the development of AD.

Published
2008

45. P2–377: CSF biomarkers correlate with regional brain volume and fMRI activation patterns in middle–aged adults at risk for Alzheimer's disease

Author

Hanna Blazel, Kimberly E. Arnold, Sanjay Asthana, Carey E. Gleason, Britta M. Torgerson, Bruce P. Hermann, Taylor W. Schmitz, Sterling C. Johnson, Zachary J. Clark, Mark A. Sager, Cynthia M. Carlsson, and Mehul A. Trivedi

Subjects
Oncology, medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Internal medicine, Csf biomarkers, Brain size, Medicine, Neurology (clinical), Geriatrics and Gerontology, business, Neuroscience
Published
2006

46. P3-062: Relationship of atherogenic lipid profiles and gender with CSF biomarkers in middle-aged adults at risk for Alzheimer's disease

Author

Cynthia M. Carlsson, Carey E. Gleason, Luigi Puglielli, Mark A. Sager, Craig S. Atwood, Jodi H. Barnet, Hanna Blazel, Sanjay Asthana, and Sterling C. Johnson

Subjects
Oncology, medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Internal medicine, Csf biomarkers, Medicine, Neurology (clinical), Geriatrics and Gerontology, business
Published
2008

Catalog

Books, media, physical & digital resources
See catalog results