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Lichen myxedematosus (LM) is a chronic cutaneous mucinosis that can present as a localized skin lesion or as a generalized systemic disease termed scleromyxedema. The differential diagnosis is determined by a combination of clinical presentation, serological studies, and histopathological examination. Currently, well‐established and accepted histopathological features to distinguish localized LM from scleromyxedema have not been elucidated. Our recent publication, together with a retrospective literature review, suggests that the presence of groups of light chain‐restricted plasma cells represents a distinct histopathological clue for the diagnosis of localized LM. In this report, we provide two additional cases of localized LM with lambda light chain‐restricted plasma cells, together with clinical and histopathological findings that are similar to our previous publication. These cases support our theory that the light chain‐restricted plasmacytic microenvironment is primarily attributed to the pathogenesis of localized LM. Therefore, we consider these cases to constitute a clinically and pathologically new variant of localized LM and name it primary localized cutaneous LM with light chain‐restricted plasma cells. [ABSTRACT FROM AUTHOR]

Reports on the treatment of refractory disseminated Mycobacterium abscessus infection with interferon gamma therapy. Description of the case of a 60-year-old woman with disseminated Mycobacterium abscessus infection; Initiation of adjunctive therapy with interferon gamma; Skin biopsy results; Treatment processes.

A letter to the editor is presented in response to the article regarding the use of proliferation rate in the differential diagnosis of dermatofibroma (DF) against definite malignant fibrohistiocytic tumors.

Microcystic adnexal carcinoma (MAC) is an uncommon, locally aggressive cutaneous neoplasm that usually presents as a slow-growing, asymptomatic lesion on the head or neck. Microcystic adnexal carcinoma frequently is misdiagnosed due to its histologic appearance on superficial biopsy specimens mimicking other follicular neoplasms. Herein, we highlight a case in which a slow-growing lesion was initially diagnosed as a trichoadenoma following superficial biopsy; however, after surgical excision the pathology revealed a locally aggressive MAC.