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2. Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study
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Raman, Betty, McCracken, Celeste, Cassar, Mark P, Moss, Alastair J, Finnigan, Lucy, Samat, Azlan Helmy A, Ogbole, Godwin, Tunnicliffe, Elizabeth M, Alfaro-Almagro, Fidel, Menke, Ricarda, Xie, Cheng, Gleeson, Fergus, Lukaschuk, Elena, Lamlum, Hanan, McGlynn, Kevin, Popescu, Iulia A, Sanders, Zeena-Britt, Saunders, Laura C, Piechnik, Stefan K, Ferreira, Vanessa M, Nikolaidou, Chrysovalantou, Rahman, Najib M, Ho, Ling-Pei, Harris, Victoria C, Shikotra, Aarti, Singapuri, Amisha, Pfeffer, Paul, Manisty, Charlotte, Kon, Onn M, Beggs, Mark, O'Regan, Declan P, Fuld, Jonathan, Weir-McCall, Jonathan R, Parekh, Dhruv, Steeds, Rick, Poinasamy, Krisnah, Cuthbertson, Dan J, Kemp, Graham J, Semple, Malcolm G, Horsley, Alexander, Miller, Christopher A, O'Brien, Caitlin, Shah, Ajay M, Chiribiri, Amedeo, Leavy, Olivia C, Richardson, Matthew, Elneima, Omer, McAuley, Hamish J C, Sereno, Marco, Saunders, Ruth M, Houchen-Wolloff, Linzy, Greening, Neil J, Bolton, Charlotte E, Brown, Jeremy S, Choudhury, Gourab, Diar Bakerly, Nawar, Easom, Nicholas, Echevarria, Carlos, Marks, Michael, Hurst, John R, Jones, Mark G, Wootton, Daniel G, Chalder, Trudie, Davies, Melanie J, De Soyza, Anthony, Geddes, John R, Greenhalf, William, Howard, Luke S, Jacob, Joseph, Man, William D-C, Openshaw, Peter J M, Porter, Joanna C, Rowland, Matthew J, Scott, Janet T, Singh, Sally J, Thomas, David C, Toshner, Mark, Lewis, Keir E, Heaney, Liam G, Harrison, Ewen M, Kerr, Steven, Docherty, Annemarie B, Lone, Nazir I, Quint, Jennifer, Sheikh, Aziz, Zheng, Bang, Jenkins, R Gisli, Cox, Eleanor, Francis, Susan, Halling-Brown, Mark, Chalmers, James D, Greenwood, John P, Plein, Sven, Hughes, Paul J C, Thompson, A A Roger, Rowland-Jones, Sarah L, Wild, James M, Kelly, Matthew, Treibel, Thomas A, Bandula, Steven, Aul, Raminder, Miller, Karla, Jezzard, Peter, Smith, Stephen, Nichols, Thomas E, McCann, Gerry P, Evans, Rachael A, Wain, Louise V, Brightling, Christopher E, Neubauer, Stefan, Baillie, J K, Shaw, Alison, Hairsine, Brigid, Kurasz, Claire, Henson, Helen, Armstrong, Lisa, Shenton, Liz, Dobson, H, Dell, Amanda, Lucey, Alice, Price, Andrea, Storrie, Andrew, Pennington, Chris, Price, Claire, Mallison, Georgia, Willis, Gemma, Nassa, Heeah, Haworth, Jill, Hoare, Michaela, Hawkings, Nancy, Fairbairn, Sara, Young, Susan, Walker, S, Jarrold, I, Sanderson, Amy, David, C, Chong-James, K, Zongo, O, James, W Y, Martineau, A, King, Bernie, Armour, C, McAulay, D, Major, E, McGinness, Jade, McGarvey, L, Magee, N, Stone, Roisin, Drain, S, Craig, T, Bolger, A, Haggar, Ahmed, Lloyd, Arwel, Subbe, Christian, Menzies, Daniel, Southern, David, McIvor, Emma, Roberts, K, Manley, R, Whitehead, Victoria, Saxon, W, Bularga, A, Mills, N L, El-Taweel, Hosni, Dawson, Joy, Robinson, Leanne, Saralaya, Dinesh, Regan, Karen, Storton, Kim, Brear, Lucy, Amoils, S, Bermperi, Areti, Elmer, Anne, Ribeiro, Carla, Cruz, Isabel, Taylor, Jessica, Worsley, J, Dempsey, K, Watson, L, Jose, Sherly, Marciniak, S, Parkes, M, McQueen, 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Beckett, P, Nanda, U, Daynes, E, Charalambou, A, Yousuf, A J, Lea, A, Prickett, A, Gooptu, Bibek, Hargadon, Beverley, Bourne, Charlotte, Christie, C, Edwardson, C, Lee, D, Baldry, E, Stringer, E, Woodhead, F, Mills, G, Arnold, H, Aung, H, Qureshi, I N, Finch, J, Skeemer, J, Hadley, K, Khunti, Kamlesh, Carr, Liesel, Ingram, L, Aljaroof, M, Bakali, M, Bakau, M, Baldwin, M, Bourne, Michelle, Pareek, Manish, Soares, M, Tobin, Martin, Armstrong, Natalie, Brunskill, Nigel, Goodman, N, Cairns, P, Haldar, Pranab, McCourt, P, Dowling, R, Russell, Richard, Diver, Sarah, Edwards, Sarah, Glover, Sarah, Parker, S, Siddiqui, Salman, Ward, T J C, Mcnally, T, Thornton, T, Yates, Tom, Ibrahim, W, Monteiro, Will, Thickett, D, Wilkinson, D, Broome, M, McArdle, P, Upthegrove, R, Wraith, D, Langenberg, C, Summers, C, Bullmore, E, Heeney, J L, Schwaeble, W, Sudlow, C L, Adeloye, D, Newby, D E, Rudan, I, Shankar-Hari, M, Thorpe, M, Pius, R, Walmsley, S, McGovern, A, Ballard, C, Allan, L, Dennis, J, Cavanagh, J, Petrie, J, O'Donnell, K, Spears, M, Sattar, N, MacDonald, S, Guthrie, E, Henderson, M, Guillen Guio, Beatriz, Zhao, Bang, Lawson, C, Overton, Charlotte, Taylor, Chris, Tong, C, Mukaetova-Ladinska, Elizabeta, Turner, E, Pearl, John E, Sargant, J, Wormleighton, J, Bingham, Michelle, Sharma, M, Steiner, Mike, Samani, Nilesh, Novotny, Petr, Free, Rob, Allen, R J, Finney, Selina, Terry, Sarah, Brugha, Terry, Plekhanova, Tatiana, McArdle, A, Vinson, B, Spencer, L G, Reynolds, W, Ashworth, M, Deakin, B, Chinoy, H, Abel, K, Harvie, M, Stanel, S, Rostron, A, Coleman, C, Baguley, D, Hufton, E, Khan, F, Hall, I, Stewart, I, Fabbri, L, Wright, L, Kitterick, P, Morriss, R, Johnson, S, Bates, A, Antoniades, C, Clark, D, Bhui, K, Channon, K M, Motohashi, K, Sigfrid, L, Husain, M, Webster, M, Fu, X, Li, X, Kingham, L, Klenerman, P, Miiler, K, Carson, G, Simons, G, Huneke, N, Calder, P C, Baldwin, D, Bain, S, Lasserson, D, Daines, L, Bright, E, Stern, M, Crisp, P, Dharmagunawardena, R, Reddington, A, Wight, A, Bailey, L, Ashish, A, Robinson, E, Cooper, J, Broadley, A, Turnbull, A, Brookes, C, Sarginson, C, Ionita, D, Redfearn, H, Elliott, K, Barman, L, Griffiths, L, Guy, Z, Gill, Rhyan, Nathu, Rashmita, Harris, Edward, Moss, P, Finnigan, J, Saunders, Kathryn, Saunders, Peter, Kon, S, Kon, Samantha S, O'Brien, Linda, Shah, K, Shah, P, Richardson, Emma, Brown, V, Brown, M, Brown, Jo, Brown, J, Brown, Ammani, Brown, Angela, Choudhury, N, Jones, S, Jones, H, Jones, L, Jones, I, Jones, G, Jones, Heather, Jones, Don, Davies, Ffyon, Davies, Ellie, Davies, Kim, Davies, Gareth, Davies, Gwyneth A, Howard, K, Porter, Julie, Rowland, J, Rowland, A, Scott, Kathryn, Singh, Suver, Singh, Claire, Thomas, S, Thomas, Caradog, Lewis, Victoria, Lewis, J, Lewis, D, Harrison, P, Francis, C, Francis, R, Hughes, Rachel Ann, Hughes, Joan, Hughes, A D, Thompson, T, Kelly, S, Smith, D, Smith, Nikki, Smith, Andrew, Smith, Jacqui, Smith, Laurie, Smith, Susan, Evans, Teriann, Evans, Ranuromanana I, Evans, D, Evans, R, Evans, H, and Evans, J
- Published
- 2023
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3. Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study
- Author
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Jackson, C, Stewart, I D, Plekhanova, T, Cunningham, P S, Hazel, A L, Al-Sheklly, B, Aul, R, Bolton, C E, Chalder, T, Chalmers, J D, Chaudhuri, N, Docherty, A B, Donaldson, G, Edwardson, C L, Elneima, O, Greening, N J, Hanley, N A, Harris, V C, Harrison, E M, Ho, L-P, Houchen-Wolloff, L, Howard, L S, Jolley, C J, Jones, M G, Leavy, O C, Lewis, K E, Lone, N I, Marks, M, McAuley, H J C, McNarry, M A, Patel, B, Piper-Hanley, K, Poinasamy, K, Raman, B, Richardson, M, Rivera-Ortega, P, Rowland-Jones, S L, Rowlands, A V, Saunders, R M, Scott, J T, Sereno, M, Shah, A M, Shikotra, A, Singapuri, A, Stanel, S C, Thorpe, M, Wootton, D G, Yates, T, Jenkins, G, Singh, S J, Man, W D-C, Brightling, C E, Wain, L V, Porter, J C, Thompson, R, Horsley, A, Molyneaux, P L, Evans, R A, Jones, S E, Rutter, M K, Blaikley, J F, Abel, K, Adamali, H, Adeloye, D, Adeyemi, O, Adrego, R, Aguilar Jimenez, L A, Ahmad, S, Ahmad Haider, N, Ahmed, R, Ahwireng, N, Ainsworth, M, Alamoudi, A, Ali, M, Aljaroof, M, All, AM, Allan, L, Allen, R J, Allerton, L, Allsop, L, Almeida, P, Altmann, D, Alvarez Corral, M, Amoils, S, Anderson, D, Antoniades, C, Arbane, G, Arias, A, Armour, C, Armstrong, L, Armstrong, N, Arnold, D, Arnold, H, Ashish, A, Ashworth, A, Ashworth, M, Aslani, S, Assefa-Kebede, H, Atkin, C, Atkin, P, Aung, H, Austin, L, Avram, C, Ayoub, A, Babores, M, Baggott, R, Bagshaw, J, Baguley, D, Bailey, L, Baillie, J K, Bain, S, Bakali, M, Bakau, M, Baldry, E, Baldwin, D, Baldwin, M, Ballard, C, Banerjee, A, Bang, B, Barker, R E, Barman, L, Barratt, S, Barrett, F, Basire, D, Basu, N, Bates, M, Bates, A, Batterham, R, Baxendale, H, Bayes, H, Beadsworth, M, Beckett, P, Beggs, M, Begum, M, Beirne, P, Bell, D, Bell, R, Bennett, K, Beranova, E, Bermperi, A, Berridge, A, Berry, C, Betts, S, Bevan, E, Bhui, K, Bingham, M, Birchall, K, Bishop, L, Bisnauthsing, K, Blaikely, J, Bloss, A, Bolger, A, Bonnington, J, Botkai, A, Bourne, C, Bourne, M, Bramham, K, Brear, L, Breen, G, Breeze, J, Briggs, A, Bright, E, Brill, S, Brindle, K, Broad, L, Broadley, A, Brookes, C, Broome, M, Brown, A, Brown, J, Brown, J S, Brown, M, Brown, V, Brugha, T, Brunskill, N, Buch, M, Buckley, P, Bularga, A, Bullmore, E, Burden, L, Burdett, T, Burn, D, Burns, G, Burns, A, Busby, J, Butcher, R, Butt, A, Byrne, S, Cairns, P, Calder, P C, Calvelo, E, Carborn, H, Card, B, Carr, C, Carr, L, Carson, G, Carter, P, Casey, A, Cassar, M, Cavanagh, J, Chablani, M, Chambers, R C, Chan, F, Channon, K M, Chapman, K, Charalambou, A, Checkley, A, Chen, J, Cheng, Y, Chetham, L, Childs, C, Chilvers, E R, Chinoy, H, Chiribiri, A, Chong-James, K, Choudhury, G, Choudhury, N, Chowienczyk, P, Christie, C, Chrystal, M, Clark, D, Clark, C, Clarke, J, Clohisey, S, Coakley, G, Coburn, Z, Coetzee, S, Cole, J, Coleman, C, Conneh, F, Connell, D, Connolly, B, Connor, L, Cook, A, Cooper, B, Cooper, J, Cooper, S, Copeland, D, Cosier, T, Coulding, M, Coupland, C, Cox, E, Craig, T, Crisp, P, Cristiano, D, Crooks, M G, Cross, A, Cruz, I, Cullinan, P, Cuthbertson, D, Daines, L, Dalton, M, Daly, P, Daniels, A, Dark, P, Dasgin, J, David, A, David, C, Davies, E, Davies, F, Davies, G, Davies, G A, Davies, K, Davies, M J, Dawson, J, Daynes, E, De Soyza, A, Deakin, B, Deans, A, Deas, C, Deery, J, Defres, S, Dell, A, Dempsey, K, Denneny, E, Dennis, J, Dewar, A, Dharmagunawardena, R, Diar-Bakerly, N, Dickens, C, Dipper, A, Diver, S, Diwanji, S N, Dixon, M, Djukanovic, R, Dobson, H, Dobson, S L, Donaldson, A, Dong, T, Dormand, N, Dougherty, A, Dowling, R, Drain, S, Draxlbauer, K, Drury, K, Dulawan, P, Dunleavy, A, Dunn, S, Dupont, C, Earley, J, Easom, N, Echevarria, C, Edwards, S, Edwardson, C, El-Taweel, H, Elliott, A, Elliott, K, Ellis, Y, Elmer, A, Evans, D, Evans, H, Evans, J, Evans, R, Evans, R I, Evans, T, Evenden, C, Evison, L, Fabbri, L, Fairbairn, S, Fairman, A, Fallon, K, Faluyi, D, Favager, C, Fayzan, T, Featherstone, J, Felton, T, Finch, J, Finney, S, Finnigan, J, Finnigan, L, Fisher, H, Fletcher, S, Flockton, R, Flynn, M, Foot, H, Foote, D, Ford, A, Forton, D, Fraile, E, Francis, C, Francis, R, Francis, S, Frankel, A, Fraser, E, Free, R, French, N, Fu, X, Fuld, J, Furniss, J, Garner, L, Gautam, N, Geddes, J R, George, J, George, P M, Gibbons, M, Gill, M, Gilmour, L, Gleeson, F, Glossop, J, Glover, S, Goodman, N, Goodwin, C, Gooptu, B, Gordon, H, Gorsuch, T, Greatorex, M, Greenhaff, P L, Greenhalf, W, Greenhalgh, A, Greenwood, J, Gregory, H, Gregory, R, Grieve, D, Griffin, D, Griffiths, L, Guerdette, A-M, Guillen Guio, B, Gummadi, M, Gupta, A, Gurram, S, Guthrie, E, Guy, Z, Henson, H, Hadley, K, Haggar, A, Hainey, K, Hairsine, B, Haldar, P, Hall, I, Hall, L, Halling-Brown, M, Hamil, R, Hancock, A, Hancock, K, Haq, S, Hardwick, H E, Hardy, E, Hardy, T, Hargadon, B, Harrington, K, Harris, E, Harrison, P, Hart, N, Harvey, A, Harvey, M, Harvie, M, Haslam, L, Havinden-Williams, M, Hawkes, J, Hawkings, N, Haworth, J, Hayday, A, Haynes, M, Hazeldine, J, Hazelton, T, Heaney, L G, Heeley, C, Heeney, J L, Heightman, M, 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4. Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study
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Evans, R A, Leavy, O C, Richardson, M, Elneima, O, McAuley, H J C, Shikotra, A, Singapuri, A, Sereno, M, Saunders, R M, Harris, V C, Houchen-Wolloff, L, Aul, R, Beirne, P, Bolton, C E, Brown, J S, Choudhury, G, Diar-Bakerly, N, Easom, N, Echevarria, C, Fuld, J, Hart, N, Hurst, J, Jones, M G, Parekh, D, Pfeffer, P, Rahman, N M, Rowland-Jones, S L, Shah, A M, Wootton, D G, Chalder, T, Davies, M J, De Soyza, A, Geddes, J R, Greenhalf, W, Greening, N J, Heaney, L G, Heller, S, Howard, L S, Jacob, J, Jenkins, R G, Lord, J M, Man, W D-C, McCann, G P, Neubauer, S, Openshaw, P J M, Porter, J C, Rowland, M J, Scott, J T, Semple, M G, Singh, S J, Thomas, D C, Toshner, M, Lewis, K E, Thwaites, R S, Briggs, A, Docherty, A B, Kerr, S, Lone, N I, Quint, J, Sheikh, A, Thorpe, M, Zheng, B, Chalmers, J D, Ho, L P, Horsley, A, Marks, M, Poinasamy, K, Raman, B, Harrison, E M, Wain, L V, Brightling, C E, Abel, K, Adamali, H, Adeloye, D, Adeyemi, O, Adrego, R, Aguilar Jimenez, L A, Ahmad, S, Ahmad Haider, 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Kurupati, P, Laing, C, Lamlum, H, Landers, G, Langenberg, C, Lasserson, D, Lavelle-Langham, L, Lawrie, A, Lawson, C, Layton, A, Lea, A, Lee, D, Lee, J-H, Lee, E, Leitch, K, Lenagh, R, Lewis, D, Lewis, J, Lewis, V, Lewis-Burke, N, Li, X, Light, T, Lightstone, L, Lilaonitkul, W, Lim, L, Linford, S, Lingford-Hughes, A, Lipman, M, Liyanage, K, Lloyd, A, Logan, S, Lomas, D, Loosley, R, Lota, H, Lovegrove, W, Lucey, A, Lukaschuk, E, Lye, A, Lynch, C, MacDonald, S, MacGowan, G, Macharia, I, Mackie, J, Macliver, L, Madathil, S, Madzamba, G, Magee, N, Magtoto, M M, Mairs, N, Majeed, N, Major, E, Malein, F, Malim, M, Mallison, G, Mandal, S, Mangion, K, Manisty, C, Manley, R, March, K, Marciniak, S, Marino, P, Mariveles, M, Marouzet, E, Marsh, S, Marshall, B, Marshall, M, Martin, J, Martineau, A, Martinez, L M, Maskell, N, Matila, D, Matimba-Mupaya, W, Matthews, L, Mbuyisa, A, McAdoo, S, Weir McCall, J, McAllister-Williams, H, McArdle, A, McArdle, P, McAulay, D, McCormick, J, McCormick, W, McCourt, P, McGarvey, L, McGee, C, Mcgee, K, McGinness, J, McGlynn, K, McGovern, A, McGuinness, H, McInnes, I B, McIntosh, J, McIvor, E, McIvor, K, McLeavey, L, McMahon, A, McMahon, M J, McMorrow, L, Mcnally, T, McNarry, M, McNeill, J, McQueen, A, McShane, H, Mears, C, Megson, C, Megson, S, Mehta, P, Meiring, J, Melling, L, Mencias, M, Menzies, D, Merida Morillas, M, Michael, A, Milligan, L, Miller, C, Mills, C, Mills, N L, Milner, L, Misra, S, Mitchell, J, Mohamed, A, Mohamed, N, Mohammed, S, Molyneaux, P L, Monteiro, W, Moriera, S, Morley, A, Morrison, L, Morriss, R, Morrow, A, Moss, A J, Moss, P, Motohashi, K, Msimanga, N, Mukaetova-Ladinska, E, Munawar, U, Murira, J, Nanda, U, Nassa, H, Nasseri, M, Neal, A, Needham, R, Neill, P, Newell, H, Newman, T, Newton-Cox, A, Nicholson, T, Nicoll, D, Nolan, C M, Noonan, M J, Norman, C, Novotny, P, Nunag, J, Nwafor, L, Nwanguma, U, Nyaboko, J, O'Donnell, K, O'Brien, C, O'Brien, L, O'Regan, D, Odell, N, Ogg, G, Olaosebikan, O, Oliver, C, Omar, Z, Orriss-Dib, L, Osborne, L, Osbourne, R, Ostermann, M, Overton, C, Owen, J, Oxton, J, Pack, J, Pacpaco, E, Paddick, S, Painter, S, Pakzad, A, Palmer, S, Papineni, P, Paques, K, Paradowski, K, Pareek, M, Parfrey, H, Pariante, C, Parker, S, Parkes, M, Parmar, J, Patale, S, Patel, B, Patel, M, Patel, S, Pattenadk, D, Pavlides, M, Payne, S, Pearce, L, Pearl, J E, Peckham, D, Pendlebury, J, Peng, Y, Pennington, C, Peralta, I, Perkins, E, Peterkin, Z, Peto, T, Petousi, N, Petrie, J, Phipps, J, Pimm, J, Piper Hanley, K, Pius, R, Plant, H, Plein, S, Plekhanova, T, Plowright, M, Polgar, O, Poll, L, Porter, J, Portukhay, S, Powell, N, Prabhu, A, Pratt, J, Price, A, Price, C, Price, D, Price, L, Prickett, A, Propescu, J, Pugmire, S, Quaid, S, Quigley, J, Qureshi, H, Qureshi, I N, Radhakrishnan, K, Ralser, M, Ramos, A, Ramos, H, Rangeley, J, Rangelov, B, Ratcliffe, L, Ravencroft, P, Reddington, A, Reddy, R, Redfearn, H, Redwood, D, Reed, A, Rees, M, Rees, T, Regan, K, Reynolds, W, Ribeiro, C, Richards, A, Richardson, E, Rivera-Ortega, P, Roberts, K, Robertson, E, Robinson, E, Robinson, L, Roche, L, Roddis, C, Rodger, J, Ross, A, Ross, G, Rossdale, J, Rostron, A, Rowe, A, Rowland, A, Rowland, J, Roy, K, Roy, M, Rudan, I, Russell, R, Russell, E, Saalmink, G, Sabit, R, Sage, E K, Samakomva, T, Samani, N, Sampson, C, Samuel, K, Samuel, R, Sanderson, A, Sapey, E, Saralaya, D, Sargant, J, Sarginson, C, Sass, T, Sattar, N, Saunders, K, Saunders, P, Saunders, L C, Savill, H, Saxon, W, Sayer, A, Schronce, J, Schwaeble, W, Scott, K, Selby, N, Sewell, T A, Shah, K, Shah, P, Shankar-Hari, M, Sharma, M, Sharpe, C, Sharpe, M, Shashaa, S, Shaw, A, Shaw, K, Shaw, V, Shelton, S, Shenton, L, Shevket, K, Short, J, Siddique, S, Siddiqui, S, Sidebottom, J, Sigfrid, L, Simons, G, Simpson, J, Simpson, N, Singh, C, Singh, S, Sissons, D, Skeemer, J, Slack, K, Smith, A, Smith, D, Smith, S, Smith, J, Smith, L, Soares, M, Solano, T S, Solly, R, Solstice, AR, Soulsby, T, Southern, D, Sowter, D, Spears, M, Spencer, L G, Speranza, F, Stadon, L, Stanel, S, Steele, N, Steiner, M, Stensel, D, Stephens, G, Stephenson, L, Stern, M, Stewart, I, Stimpson, R, Stockdale, S, Stockley, J, Stoker, W, Stone, R, Storrar, W, Storrie, A, Storton, K, Stringer, E, Strong-Sheldrake, S, Stroud, N, Subbe, C, Sudlow, C L, Suleiman, Z, Summers, C, Summersgill, C, Sutherland, D, Sykes, D L, Sykes, R, Talbot, N, Tan, A L, Tarusan, L, Tavoukjian, V, Taylor, A, Taylor, C, Taylor, J, Te, A, Tedd, H, Tee, CJ, Teixeira, J, Tench, H, Terry, S, Thackray-Nocera, S, Thaivalappil, F, Thamu, B, Thickett, D, Thomas, C, Thomas, S, Thomas, A K, Thomas-Woods, T, Thompson, T, Thompson, A A R, Thornton, T, Tilley, J, Tinker, N, Tiongson, G F, Tobin, M, Tomlinson, J, Tong, C, Touyz, R, Tripp, K A, Tunnicliffe, E, Turnbull, A, Turner, E, Turner, S, Turner, V, Turner, K, Turney, S, Turtle, L, Turton, H, Ugoji, J, Ugwuoke, R, Upthegrove, R, Valabhji, J, Ventura, M, Vere, J, Vickers, C, Vinson, B, Wade, E, Wade, P, Wainwright, T, Wajero, L O, Walder, S, Walker, S, Wall, E, Wallis, T, Walmsley, S, Walsh, J A, Walsh, S, Warburton, L, Ward, T J C, Warwick, K, Wassall, H, Waterson, S, Watson, E, Watson, L, Watson, J, Welch, C, Welch, H, Welsh, B, Wessely, S, West, S, Weston, H, Wheeler, H, White, S, Whitehead, V, Whitney, J, Whittaker, S, Whittam, B, Whitworth, V, Wight, A, Wild, J, Wilkins, M, Wilkinson, D, Williams, N, Williams, J, Williams-Howard, S A, Willicombe, M, Willis, G, Willoughby, J, Wilson, A, Wilson, D, Wilson, I, Window, N, Witham, M, Wolf-Roberts, R, Wood, C, Woodhead, F, Woods, J, Wormleighton, J, Worsley, J, Wraith, D, Wrey Brown, C, Wright, C, Wright, L, Wright, S, Wyles, J, Wynter, I, Xu, M, Yasmin, N, Yasmin, S, Yates, T, Yip, K P, Young, B, Young, S, Young, A, Yousuf, A J, Zawia, A, Zeidan, L, Zhao, B, and Zongo, O
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- 2022
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5. Immunotherapy of Multiple Myeloma: Current Status as Prologue to the Future
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Hanley N. Abramson
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myeloma ,daratumumab ,bispecific antibodies ,chimeric antigen receptor T-cells ,immunotherapy ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
The landscape of therapeutic measures to treat multiple myeloma has undergone a seismic shift since the dawn of the current century. This has been driven largely by the introduction of new classes of small molecules, such as proteasome blockers (e.g., bortezomib) and immunomodulators (e.g., lenalidomide), as well as by immunotherapeutic agents starting with the anti-CD38 monoclonal antibody daratumumab in 2015. Recently, other immunotherapies have been added to the armamentarium of drugs available to fight this malignancy. These include the bispecifics teclistamab, talquetamab, and elranatamab, and the chimeric antigen receptor (CAR) T-cell products idecabtagene vicleucel (ide-cel) and ciltacabtagene autoleucel (cilta-cel). While the accumulated benefits of these newer agents have resulted in a more than doubling of the disease’s five-year survival rate to nearly 60% and improved quality of life, the disease remains incurable, as patients become refractory to the drugs and experience relapse. This review covers the current scope of antimyeloma immunotherapeutic agents, both those in clinical use and in development. Included in the discussion are additional monoclonal antibodies (mAbs), antibody–drug conjugates (ADCs), bi- and multitargeted mAbs, and CAR T-cells and emerging natural killer (NK) cells, including products intended for “off-the-shelf” (allogeneic) applications. Emphasis is placed on the benefits of each along with the challenges that need to be surmounted if MM is to be cured.
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- 2023
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6. Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study
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Abel, K, Adamali, H, Adeloye, D, Adeyemi, O, Adeyemi, F, Ahmad, S, Ahmed, R, Ainsworth, M, Al-Sheklly, B, Alamoudi, A, Aljaroof, M, Allan, L, Allen, R, Alli, A, Altmann, D, Anderson, D, Andrews, M, Angyal, A, Antoniades, C, Arbane, G, Armour, C, Armstrong, N, Armstrong, L, Arnold, H, Arnold, D, Ashworth, M, Ashworth, A, Assefa-Kebede, H, Atkin, P, Atkins, H, Atkins, A, Aul, R, Avram, C, Baggott, R, Baguley, D, Baillie, J K, Bain, S, Bakali, M, Bakau, M, Baldry, E, Baldwin, D, Ballard, C, Bambrough, J, Barker, R E, Barratt, S, Barrett, F, Basire, D, Basu, N, Batterham, R, Baxendale, H, Bayes, H, Bayley, M, Beadsworth, M, Beirne, P, Bell, R, Bell, D, Berry, C, Betts, S, Bhui, K, Bishop, L, Blaikely, J, Bloomfield, C, Bloss, A, Bolger, A, Bolton, C E, Bonnington, J, Botkai, A, Bourne, M, Bourne, C, Bradley, E, Bramham, K, Brear, L, Breen, G, Breeze, J, Briggs, A, Bright, E, Brightling, C E, Brill, S, Brindle, K, Broad, L, Broome, M, Brown, J S, Brown, M, Brown, J, Brown, R, Brown, V, Brown, A, Brugha, T, Brunskill, N, Buch, M, Bularga, A, Bullmore, E, Burn, D, Burns, G, Busby, J, Buttress, A, Byrne, S, Cairns, P, Calder, P C, Calvelo, E, Card, B, Carr, L, Carson, G, Carter, P, Cavanagh, J, Chalder, T, Chalmers, J D, Chambers, R C, Channon, K, Chapman, K, Charalambou, A, Chaudhuri, N, Checkley, A, Chen, J, Chetham, L, Chilvers, E R, Chinoy, H, Chong-James, K, Choudhury, N, Choudhury, G, Chowdhury, P, Chowienczyk, P, Christie, C, Clark, D, Clark, C, Clarke, J, Clift, P, Clohisey, S, Coburn, Z, Cole, J, Coleman, C, Connell, D, Connolly, B, Connor, L, Cook, A, Cooper, B, Coupland, C, Craig, T, Crisp, P, Cristiano, D, Crooks, M G, Cross, A, Cruz, I, Cullinan, P, Daines, L, Dalton, M, Dark, P, Dasgin, J, David, A, David, C, Davies, M, Davies, G, Davies, K, Davies, F, Davies, G A, Daynes, E, De Silva, T, De Soyza, A, Deakin, B, Deans, A, Defres, S, Dell, A, Dempsey, K, Dennis, J, Dewar, A, Dharmagunawardena, R, Diar Bakerly, N, Dipper, A, Diver, S, Diwanji, S N, Dixon, M, Djukanovic, R, Dobson, H, Dobson, C, Dobson, S L, Docherty, A B, Donaldson, A, Dong, T, Dormand, N, Dougherty, A, Dowling, R, Drain, S, Dulawan, P, Dunleavy, A, Dunn, S, Easom, N, Echevarria, C, Edwards, S, Edwardson, C, Elliott, B, Elliott, A, Ellis, Y, Elmer, A, Elneima, O, Evans, R A, Evans, J, Evans, H, Evans, D, Evans, R I, Evans, R, Evans, T, Fabbri, L, Fairbairn, S, Fairman, A, Fallon, K, Faluyi, D, Favager, C, Felton, T, Finch, J, Finney, S, Fisher, H, Fletcher, S, Flockton, R, Foote, D, Ford, A, Forton, D, Francis, R, Francis, S, Francis, C, Frankel, A, Fraser, E, Free, R, French, N, Fuld, J, Furniss, J, Garner, L, Gautam, N, Geddes, J R, George, P M, George, J, Gibbons, M, Gilmour, L, Gleeson, F, Glossop, J, Glover, S, Goodman, N, Gooptu, B, Gorsuch, T, Gourlay, E, Greenhaff, P, Greenhalf, W, Greenhalgh, A, Greening, N J, Greenwood, J, Greenwood, S, Gregory, R, Grieve, D, Gummadi, M, Gupta, A, Gurram, S, Guthrie, E, Hadley, K, Haggar, A, Hainey, K, Haldar, P, Hall, I, Hall, L, Halling-Brown, M, Hamil, R, Hanley, N A, Hardwick, H E, Hardy, E, Hargadon, B, Harrington, K, Harris, V, Harrison, E M, Harrison, P, Hart, N, Harvey, A, Harvey, M, Harvie, M, Havinden-Williams, M, Hawkes, J, Hawkings, N, Haworth, J, Hayday, A, Heaney, L G, Heeney, J L, Heightman, M, Heller, S, Henderson, M, Hesselden, L, Hillman, T, Hingorani, A, Hiwot, T, Ho, L P, Hoare, A, Hoare, M, Hogarth, P, Holbourn, A, Holdsworth, L, Holgate, D, Holmes, K, Holroyd-Hind, B, Horsley, A, Hosseini, A, Hotopf, M, Houchen, L, Howard, L, Howell, A, Hufton, E, Hughes, A, Hughes, J, Hughes, R, Humphries, A, Huneke, N, Hurst, J R, Hurst, R, Husain, M, Hussell, T, Ibrahim, W, Ient, A, Ingram, L, Ismail, K, Jackson, T, Jacob, J, James, W Y, Janes, S, Jarvis, H, Jayaraman, B, Jenkins, R G, Jezzard, P, Jiwa, K, Johnson, S, Johnson, C, Johnston, D, Jolley, C, Jolley, C J, Jones, I, Jones, S, Jones, D, Jones, H, Jones, G, Jones, M, Jose, S, Kabir, T, Kaltsakas, G, Kamwa, V, Kar, P, Kausar, Z, Kelly, S, Kerr, S, Key, A L, Khan, F, Khunti, K, King, C, King, B, Kitterick, P, Klenerman, P, Knibbs, L, Knight, S, Knighton, A, Kon, O M, Kon, S, Kon, S S, Korszun, A, Kotanidis, C, Koychev, I, Kurupati, P, Kwan, J, Laing, C, Lamlum, H, Landers, G, Langenberg, C, Lasserson, D, Lawrie, A, Lea, A, Leavy, O C, Lee, D, Lee, E, Leitch, K, Lenagh, R, Lewis, K, Lewis, V, Lewis, K E, Lewis, J, Lewis-Burke, N, Light, T, Lightstone, L, Lim, L, Linford, S, Lingford-Hughes, A, Lipman, M, Liyanage, K, Lloyd, A, Logan, S, Lomas, D, Lone, N I, Loosley, R, Lord, J M, Lota, H, Lucey, A, MacGowan, G, Macharia, I, Mackay, C, Macliver, L, Madathil, S, Madzamba, G, Magee, N, Mairs, N, Majeed, N, Major, E, Malim, M, Mallison, G, Man, W, Mandal, S, Mangion, K, Mansoori, P, Marciniak, S, Mariveles, M, Marks, M, Marshall, B, Martineau, A, Maskell, N, Matila, D, Matthews, L, Mayet, J, McAdoo, S, McAllister-Williams, H, McArdle, P, McArdle, A, McAulay, D, McAuley, H J C, McAuley, D F, McCafferty, K, McCann, G P, McCauley, H, McCourt, P, Mcgarvey, L, McGinness, J, McGovern, A, McGuinness, H, McInnes, I B, McIvor, K, McIvor, E, McMahon, A, McMahon, M J, McMorrow, L, Mcnally, T, McNarry, M, McQueen, A, McShane, H, Megson, S, Meiring, J, Menzies, D, Michael, A, Michael, B D, Milligan, L, Mills, N, Mitchell, J, Mohamed, A, Molyneaux, P L, Monteiro, W, Morley, A, Morrison, L, Morriss, R, Morrow, A, Moss, A, Moss, A J, Moss, P, Mukaetova-Ladinska, E, Munawar, U, Murali, E, Murira, J, Nassa, H, Neill, P, Neubauer, S, Newby, D, Newell, H, Newton Cox, A, Nicholson, T, Nicoll, D, Nolan, C M, Noonan, M J, Novotny, P, Nunag, J, Nyaboko, J, O'Brien, L, Odell, N, Ogg, G, Olaosebikan, O, Oliver, C, Omar, Z, Openshaw, P J M, Osbourne, R, Ostermann, M, Overton, C, Oxton, J, Pacpaco, E, Paddick, S, Papineni, P, Paradowski, K, Pareek, M, Parekh, D, Parfrey, H, Pariante, C, Parker, S, Parkes, M, Parmar, J, Parvin, R, Patale, S, Patel, B, Patel, S, Patel, M, Pathmanathan, B, Pavlides, M, Pearl, J E, Peckham, D, Pendlebury, J, Peng, Y, Pennington, C, Peralta, I, Perkins, E, Peto, T, Petousi, N, Petrie, J, Pfeffer, P, Phipps, J, Pimm, J, Piper Hanley, K, Pius, R, Plein, S, Plekhanova, T, Poinasamy, K, Polgar, O, Poll, L, Porter, J C, Portukhay, S, Powell, N, Price, L, Price, D, Price, A, Price, C, Prickett, A, Quaid, S, Quigley, J, Quint, J, Qureshi, H, Rahman, N, Rahman, M, Ralser, M, Raman, B, Ramos, A, Rangeley, J, Rees, T, Regan, K, Richards, A, Richardson, M, Rivera-Ortega, P, Robertson, E, Rodgers, J, Ross, G, Rossdale, J, Rostron, A, Routen, A, Rowland, A, Rowland, M J, Rowland, J, Rowland-Jones, S L, Roy, K, Rudan, I, Russell, R, Russell, E, Sabit, R, Sage, E K, Samani, N, Samuel, R, Sapey, E, Saralaya, D, Saratzis, A, Sargeant, J, Sass, T, Sattar, N, Saunders, K, Saunders, R, Saxon, W, Sayer, A, Schwaeble, W, Scott, J, Scott, K, Selby, N, Semple, M G, Sereno, M, Shah, K, Shah, A, Shah, P, Sharma, M, Sharpe, M, Sharpe, C, Shaw, V, Sheikh, A, Shevket, K, Shikotra, A, Short, J, Siddiqui, S, Sigfrid, L, Simons, G, Simpson, J, Singapuri, A, Singh, S J, Singh, C, Singh, S, Skeemer, J, Smith, I, Smith, J, Smith, L, Smith, A, Soares, M, Southern, D, Spears, M, Spencer, L G, Speranza, F, Stadon, L, Stanel, S, Steiner, M, Stensel, D, Stern, M, Stewart, I, Stockley, J, Stone, R, Storrie, A, Storton, K, Stringer, E, Subbe, C, Sudlow, C, Suleiman, Z, Summers, C, Summersgill, C, Sutherland, D, Sykes, D L, Sykes, R, Talbot, N, Tan, A L, Taylor, C, Taylor, A, Te, A, Tedd, H, Tee, C J, Tench, H, Terry, S, Thackray-Nocera, S, Thaivalappil, F, Thickett, D, Thomas, D, Thomas, D C, Thomas, A K, Thompson, A A R, Thompson, T, Thornton, T, Thwaites, R S, Tobin, M, Toingson, G F, Tong, C, Toshner, M, Touyz, R, Tripp, K A, Tunnicliffe, E, Turner, E, Turtle, L, Turton, H, Ugwuoke, R, Upthegrove, R, Valabhji, J, Vellore, K, Wade, E, Wain, L V, Wajero, L O, Walder, S, Walker, S, Wall, E, Wallis, T, Walmsley, S, Walsh, S, Walsh, J A, Watson, L, Watson, J, Watson, E, Welch, C, Welch, H, Welsh, B, Wessely, S, West, S, Wheeler, H, Whitehead, V, Whitney, J, Whittaker, S, Whittam, B, Wild, J, Wilkins, M, Wilkinson, D, Williams, N, Williams, B, Williams, J, Williams-Howard, S A, Willicombe, M, Willis, G, Wilson, D, Wilson, I, Window, N, Witham, M, Wolf-Roberts, R, Woodhead, F, Woods, J, Wootton, D, Worsley, J, Wraith, D, Wright, L, Wright, C, Wright, S, Xie, C, Yasmin, S, Yates, T, Yip, K P, Young, B, Young, S, Young, A, Yousuf, A J, Yousuf, A, Zawia, A, Zhao, B, Zongo, O, Evans, Rachael A, McAuley, Hamish J C, Harrison, Ewen M, Shikotra, Aarti, Singapuri, Amisha, Sereno, Marco, Elneima, Omer, Docherty, Annemarie B, Lone, Nazir I, Leavy, Olivia C, Daines, Luke, Baillie, J Kenneth, Brown, Jeremy S, Chalder, Trudie, De Soyza, Anthony, Diar Bakerly, Nawar, Easom, Nicholas, Geddes, John R, Greening, Neil J, Hart, Nick, Heaney, Liam G, Heller, Simon, Howard, Luke, Hurst, John R, Jacob, Joseph, Jenkins, R Gisli, Jolley, Caroline, Kerr, Steven, Kon, Onn M, Lewis, Keir, Lord, Janet M, McCann, Gerry P, Neubauer, Stefan, Openshaw, Peter J M, Parekh, Dhruv, Pfeffer, Paul, Rahman, Najib M, Raman, Betty, Richardson, Matthew, Rowland, Matthew, Semple, Malcolm G, Shah, Ajay M, Singh, Sally J, Sheikh, Aziz, Thomas, David, Toshner, Mark, Chalmers, James D, Ho, Ling-Pei, Horsley, Alex, Marks, Michael, Poinasamy, Krisnah, Wain, Louise V, and Brightling, Christopher E
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- 2021
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7. Recent Advances in the Applications of Small Molecules in the Treatment of Multiple Myeloma
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Hanley N. Abramson
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myeloma ,melflufen ,cereblon E3 ligase modulators ,venetoclax ,selinexor ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Therapy for multiple myeloma (MM), a hematologic neoplasm of plasma cells, has undergone remarkable changes over the past 25 years. Small molecules (molecular weight of less than one kDa), together with newer immunotherapies that include monoclonal antibodies, antibody-drug conjugates, and most recently, chimeric antigen receptor (CAR) T-cells, have combined to double the disease’s five-year survival rate to over 50% during the past few decades. Despite these advances, the disease is still considered incurable, and its treatment continues to pose substantial challenges, since therapeutic refractoriness and patient relapse are exceedingly common. This review focuses on the current pipeline, along with the contemporary roles and future prospects for small molecules in MM therapy. While small molecules offer prospective benefits in terms of oral bioavailability, cellular penetration, simplicity of preparation, and improved cost–benefit considerations, they also pose problems of toxicity due to off-target effects. Highlighted in the discussion are recent developments in the applications of alkylating agents, immunomodulators, proteasome inhibitors, apoptosis inducers, kinesin spindle protein inhibitors, blockers of nuclear transport, and drugs that affect various kinases involved in intracellular signaling pathways. Molecular and cellular targets are described for each class of agents in relation to their roles as drivers of MM.
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- 2023
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8. Willingness to pay for policies to reduce future deaths from climate change: evidence from a British survey
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Graham, H., de Bell, S., Hanley, N., Jarvis, S., and White, P.C.L.
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- 2019
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9. Valuing the economic benefits of species recovery programmes.
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Browning, E., Christie, M., Czajkowski, M., Chalak, A., Drummond, R., Hanley, N., Jones, K. E., Kuyer, J., and Provins, A.
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STATED preference methods ,EVIDENCE gaps ,AUTOMOBILE restoration ,WILLINGNESS to pay ,SPECIES - Abstract
Accounting for the values placed on nature by the public is key to successful policies in reversing ongoing biodiversity declines. However, biodiversity values are rarely included in policy decisions, resulting in poorer outcomes for people and nature.Our paper addresses an important evidence gap related to the non‐availability of values for appraising large‐scale policies and investment programmes for species recovery and habitat improvement at the national level.We use a stated preference choice modelling approach to estimate household preferences and Willingness to Pay for species recovery and habitat improvement over a wide range of habitats in England.The framing of our stated preference study is crucial to the evidence we develop. Within the study, we define species recovery as incremental improvements to habitat quality and present respondents with choices between conservation policy options that improve different habitat types. We then use the response data to estimate values for habitat quality improvements, and the associated improvements to species presence and abundance. We are thus able to estimate economic benefits for 'wild species recovery' simultaneously across a wide range of habitat types.Willingness to pay values for habitat improvement was found to be highest for improvements from 'moderate' to 'full' species recovery by 2042; and for habitat types which have relatively low current extents in England, such as lowland fens.Policy Implications: biodiversity policy designers can make use of stated preference methods to guide decisions over which aspects of biodiversity targets to focus more resources on, since this enables policy to reflect public preferences, and thus engages higher public support for conservation. In our specific data and context, this implies prioritising the restoration of species recovery to high levels and focussing resources on scarcer rather than more abundant habitat types. Read the free Plain Language Summary for this article on the Journal blog. Read the free Plain Language Summary for this article on the Journal blog. [ABSTRACT FROM AUTHOR]
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- 2024
- Full Text
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10. Immunotherapy of Multiple Myeloma: Current Status as Prologue to the Future
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Abramson, Hanley N., primary
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- 2023
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11. Long COVID research: an update from the PHOSP-COVID Scientific Summit
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Brightling, Christopher E, primary, Evans, Rachael A, additional, Singapuri, Amisha, additional, Smith, Nikki, additional, Wain, Louise V, additional, Brightling, C E, additional, Evans, R A, additional, Wain, L V, additional, Chalmers, J D, additional, Harris, V C, additional, Ho, L P, additional, Horsley, A, additional, Houchen-Wolloff, L, additional, Marks, M, additional, Raman, B, additional, Singapuri, A, additional, Barran, P, additional, Bingham, M, additional, Chilvers, E R, additional, Daynes, E, additional, Efstathiou, C M, additional, Elneima, O, additional, Guillen Guio, B, additional, Harrison, E M, additional, Jenkins, R G, additional, Liew, F, additional, Lone, N I, additional, Lord, J M, additional, McAuley, H J C, additional, McCann, G P, additional, Mitchell, J, additional, Plekhanova, T, additional, Russell, R J, additional, Saunders, R M, additional, Semple, M G, additional, Smith, N, additional, Trivedi, D, additional, Turtle, L, additional, Walker, S, additional, Abel, K, additional, Adamali, H, additional, Adeloye, D, additional, Adeyemi, O, additional, Adrego, R, additional, Aguilar Jimenez, L A, additional, Ahmad, S, additional, Ahmad Haider, N, additional, Ahmed, R, additional, Ahwireng, N, additional, Ainsworth, M, additional, Al-Sheklly, B, additional, Alamoudi, A, additional, Ali, M, additional, Aljaroof, M, additional, Allan, L, additional, Allen, R J, additional, Allerton, L, additional, Allsop, L, additional, Allt, AM, additional, Almeida, P, additional, Altmann, D, additional, Alvarez Corral, M, additional, Amoils, S, additional, Anderson, D, additional, Antoniades, C, additional, Arbane, G, additional, Arias, A, additional, Armour, C, additional, Armstrong, L, additional, Armstrong, N, additional, Arnold, D, additional, Arnold, H, additional, Ashish, A, additional, Ashworth, A, additional, Ashworth, M, additional, Aslani, S, additional, Assefa-Kebede, H, additional, Atkin, P, additional, Atkin, C, additional, Aul, R, additional, 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additional, Betts, S, additional, Bevan, E, additional, Bhui, K, additional, Birchall, K, additional, Bishop, L, additional, Bisnauthsing, K, additional, Blaikely, J, additional, Bloss, A, additional, Bolger, A, additional, Bolton, C E, additional, Bonnington, J, additional, Botkai, A, additional, Bourne, C, additional, Bourne, M, additional, Bramham, K, additional, Brear, L, additional, Breen, G, additional, Breeze, J, additional, Breeze, K, additional, Briggs, A, additional, Bright, E, additional, Brill, S, additional, Brindle, K, additional, Broad, L, additional, Broadley, A, additional, Brookes, C, additional, Broome, M, additional, Brown, V, additional, Brown, M, additional, Brown, J, additional, Brown, A, additional, Brown, J S, additional, Brugha, T, additional, Brunskill, N, additional, Buch, M, additional, Buckley, P, additional, Bularga, A, additional, Bullmore, E, additional, Bunker, J, additional, Burden, L, additional, Burdett, T, additional, Burn, D, additional, Burns, G, additional, Burns, A, additional, Busby, J, additional, Butcher, R, additional, Butt, A, additional, Byrne, S, additional, Cairns, P, additional, Calder, P C, additional, Calvelo, E, additional, Carborn, H, additional, Card, B, additional, Carr, C, additional, Carr, L, additional, Carson, G, additional, Carter, P, additional, Casey, A, additional, Cassar, M, additional, Cavanagh, J, additional, Chablani, M, additional, Chalder, T, additional, Chambers, R C, additional, Chan, F, additional, Channon, K M, additional, Chapman, K, additional, Charalambou, A, additional, Chaudhuri, N, additional, Checkley, A, additional, Chen, J, additional, Cheng, Y, additional, Chetham, L, additional, Childs, C, additional, Chinoy, H, additional, Chiribiri, A, additional, Chong-James, K, additional, Choudhury, N, additional, Choudhury, G, additional, Chowienczyk, P, additional, Christie, C, additional, Chrystal, M, additional, Clark, C, additional, Clark, D, additional, Clarke, J, additional, Clohisey, S, 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additional, Jastrub, R, additional, Jayaraman, B, additional, Jezzard, P, additional, Jiwa, K, additional, Johnson, C, additional, Johnson, S, additional, Johnston, D, additional, Jolley, C J, additional, Jones, S, additional, Jones, H, additional, Jones, L, additional, Jones, I, additional, Jones, G, additional, Jones, M G, additional, Jones, D, additional, Jose, S, additional, Kabir, T, additional, Kaltsakas, G, additional, Kamwa, V, additional, Kanellakis, N, additional, Kaprowska, S, additional, Kausar, Z, additional, Keenan, N, additional, Kelly, S, additional, Kemp, G, additional, Kerr, S, additional, Kerslake, H, additional, Key, A L, additional, Khan, F, additional, Khunti, K, additional, Kilroy, S, additional, King, B, additional, King, C, additional, Kingham, L, additional, Kirk, J, additional, Kitterick, P, additional, Klenerman, P, additional, Knibbs, L, additional, Knight, S, additional, Knighton, A, additional, Kon, O, additional, Kon, S, additional, Kon, S S, additional, Korszun, A, additional, Koychev, I, additional, Kurasz, C, additional, Kurupati, P, additional, Laing, C, additional, Lamlum, H, additional, Landers, G, additional, Langenberg, C, additional, Lavelle-Langham, L, additional, Lawrie, A, additional, Lawson, C, additional, Layton, A, additional, Lea, A, additional, Leavy, O C, additional, Lee, J-H, additional, Lee, E, additional, Lee, D, additional, Leitch, K, additional, Lenagh, R, additional, Lewis, V, additional, Lewis, J, additional, Lewis, K E, additional, Lewis, D, additional, Lewis-Burke, N, additional, Li, X, additional, Light, T, additional, Lightstone, L, additional, Lilaonitkul, W, additional, Lim, L, additional, Linford, S, additional, Lingford-Hughes, A, additional, Lipman, M, additional, Liyanage, K, additional, Lloyd, A, additional, Logan, S, additional, Lomas, D, additional, Loosley, R, additional, Lota, H, additional, Lovegrove, W, additional, Lucey, A, additional, Lucy, L, additional, Lukaschuk, E, additional, Lye, A, additional, Lynch, C, additional, MacDonald, S, additional, MacGowan, G, additional, Macharia, I, additional, Mackie, J, additional, Macliver, L, additional, Madathil, S, additional, Madzamba, G, additional, Magee, N, additional, Magtoto, M M, additional, Mairs, N, additional, Majeed, N, additional, Major, E, additional, Malein, F, additional, Malim, M, additional, Mallison, G, additional, Man, W D-C, additional, Mandal, S, additional, Mangion, K, additional, Manisty, C, additional, Manley, R, additional, March, K, additional, Marciniak, S, additional, Marino, P, additional, Mariveles, M, additional, Marouzet, E, additional, Marsh, S, additional, Marshall, M, additional, Marshall, B, additional, Martin, J, additional, Martineau, A, additional, Martinez, L M, additional, Maskell, N, additional, Matila, D, additional, Matimba-Mupaya, W, additional, Matthews, L, additional, Mbuyisa, A, additional, McAdoo, S, additional, McAllister-Williams, H, additional, McArdle, P, additional, McArdle, A, additional, McAulay, D, additional, McCormick, W, additional, McCormick, J, additional, McCourt, P, additional, McCracken, C, additional, McGarvey, L, additional, McGee, C, additional, Mcgee, K, additional, McGinness, J, additional, McGlynn, K, additional, McGovern, A, additional, McGuinness, H, additional, McInnes, I B, additional, McIntosh, J, additional, McIvor, E, additional, McIvor, K, additional, McLeavey, L, additional, McMahon, A, additional, McMahon, M J, additional, McMorrow, L, additional, Mcnally, T, additional, McNarry, M, additional, McNeill, J, additional, McQueen, A, additional, McShane, H, additional, Mears, C, additional, Megson, C, additional, Megson, S, additional, Mehta, P, additional, Meiring, J, additional, Melling, L, additional, Mencias, M, additional, Menke, R, additional, Menzies, D, additional, Merida Morillas, M, additional, Michael, A, additional, Michael, B, additional, Miller, C A, additional, Milligan, L, additional, Mills, N L, additional, Mills, C, additional, Mills, G, additional, Milner, L, additional, Misra, S, additional, Mohamed, A, additional, Mohamed, N, additional, Mohammed, S, additional, Molyneaux, P L, additional, Monteiro, W, additional, Moriera, S, additional, Morley, A, additional, Morrison, L, additional, Morriss, R, additional, Morrow, A, additional, Moss, P, additional, Moss, A J, additional, Motohashi, K, additional, Msimanga, N, additional, Mukaetova-Ladinska, E, additional, Munawar, U, additional, Murira, J, additional, Nanda, U, additional, Nassa, H, additional, Nasseri, M, additional, Nathu, R, additional, Neal, A, additional, Needham, R, additional, Neill, P, additional, Neubauer, S, additional, Newby, D E, additional, Newell, H, additional, Newman, J, additional, Newman, T, additional, Newton-Cox, A, additional, Nichols, T E, additional, Nicholson, T, additional, Nicolaou, C, additional, Nicoll, D, additional, Nikolaidis, A, additional, Nikolaidou, C, additional, Nolan, C M, additional, Noonan, M J, 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additional, Spencer, L G, additional, Speranza, F, additional, Stadon, L, additional, Stanel, S, additional, Steeds, R, additional, Steele, N, additional, Steiner, M, additional, Stensel, D, additional, Stephens, G, additional, Stephenson, L, additional, Stern, M, additional, Stewart, I, additional, Stimpson, R, additional, Stockdale, S, additional, Stockley, J, additional, Stoker, W, additional, Stone, R, additional, Storrar, W, additional, Storrie, A, additional, Storton, K, additional, Stringer, E, additional, Strong-Sheldrake, S, additional, Stroud, N, additional, Subbe, C, additional, Sudlow, C L, additional, Suleiman, Z, additional, Summers, C, additional, Summersgill, C, additional, Sutherland, D, additional, Sykes, D L, additional, Sykes, R, additional, Talbot, N, additional, Tan, A L, additional, Tarusan, L, additional, Tavoukjian, V, additional, Taylor, J, additional, Taylor, A, additional, Taylor, C, additional, Taylor, J P, additional, Te, A, additional, Tedd, H, 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- 2023
- Full Text
- View/download PDF
12. The Multiple Myeloma Drug Pipeline—2018: A Review of Small Molecules and Their Therapeutic Targets
- Author
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Abramson, Hanley N.
- Published
- 2018
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13. Longitudinal changes in EEG power, sleep cycles and behaviour in a tau model of neurodegeneration
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Holton, C. M., Hanley, N., Shanks, E., Oxley, P., McCarthy, A., Eastwood, B. J., Murray, T. K., Nickerson, A., and Wafford, K. A.
- Published
- 2020
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14. Estimating Mean Willingness to Pay from Dichotomous Choice Contingent Valuation Studies
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Buckland, S. T., Macmillan, D. C., Duff, E. I., and Hanley, N.
- Published
- 1999
15. What a Difference a Stochastic Process Makes: Epidemiological-Based Real Options Models of Optimal Treatment of Disease
- Author
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Dangerfield, C. E., Whalley, A. E., Hanley, N., and Gilligan, C. A.
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- 2018
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16. Recent Advances in the Applications of Small Molecules in the Treatment of Multiple Myeloma
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Abramson, Hanley N., primary
- Published
- 2023
- Full Text
- View/download PDF
17. The effects of sleep disturbance on dyspnoea and impaired lung function following COVID-19 hospitalisation: a prospective multi-centre cohort study
- Author
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Jackson, C., primary, Stewart, I., additional, Plekhanova, T., additional, Cunningham, P., additional, Hazel, A. L., additional, Al-Sheklly, B., additional, Aul, R., additional, Bolton, C. E., additional, Chalder, T., additional, Chalmers, J. D., additional, Chaudhuri, N., additional, Docherty, A. B., additional, Donaldson, G., additional, Edwardson, C. L., additional, Elneima, O., additional, Greening, N. J., additional, Hanley, N. A., additional, Harris, V. C., additional, Harrison, E. M., additional, Ho, L-P., additional, Houchen-Wolloff, L., additional, Howard, L. S., additional, Jolley, C. J., additional, Jones, M. G., additional, Leavy, O. C., additional, Lewis, K. E., additional, Lone, N. I., additional, Marks, M., additional, McAuley, H. J. C., additional, McNarry, M. A., additional, Patel, B., additional, Piper-Hanley, K., additional, Poinasamy, K., additional, Raman, B., additional, Richardson, M., additional, Rivera-Ortega, P., additional, Rowland-Jones, S., additional, Rowlands, A. V., additional, Saunders, R. M., additional, Scott, J. T., additional, Sereno, M., additional, Shah, A., additional, Shikotra, A., additional, Singapuri, A., additional, Stanel, S. C., additional, Thorpe, M., additional, Wootton, D. G., additional, Yates, T., additional, Jenkins, R. G., additional, Singh, S., additional, Man, W. D-C., additional, Brightling, C. E., additional, Wain, L. V., additional, Porter, J. C., additional, Thompson, A. A. R., additional, Horsley, A., additional, Molyneaux, P. L., additional, Evans, R. A., additional, Jones, S. E., additional, Rutter, M. K., additional, and Blaikley, J. F., additional
- Published
- 2022
- Full Text
- View/download PDF
18. B-Cell Maturation Antigen (BCMA) as a Target for New Drug Development in Relapsed and/or Refractory Multiple Myeloma
- Author
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Hanley N. Abramson
- Subjects
myeloma ,BCMA ,bispecific T-cell engager ,antibody-drug conjugates ,chimeric antigen receptor T-cells ,belantamab mafodotin ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
During the past two decades there has been a major shift in the choice of agents to treat multiple myeloma, whether newly diagnosed or in the relapsed/refractory stage. The introduction of new drug classes, such as proteasome inhibitors, immunomodulators, and anti-CD38 and anti-SLAMF7 monoclonal antibodies, coupled with autologous stem cell transplantation, has approximately doubled the disease’s five-year survival rate. However, this positive news is tempered by the realization that these measures are not curative and patients eventually relapse and/or become resistant to the drug’s effects. Thus, there is a need to discover newer myeloma-driving molecular markers and develop innovative drugs designed to precisely regulate the actions of such putative targets. B cell maturation antigen (BCMA), which is found almost exclusively on the surfaces of malignant plasma cells to the exclusion of other cell types, including their normal counterparts, has emerged as a specific target of interest in this regard. Immunotherapeutic agents have been at the forefront of research designed to block BCMA activity. These agents encompass monoclonal antibodies, such as the drug conjugate belantamab mafodotin; bispecific T-cell engager strategies exemplified by AMG 420; and chimeric antigen receptor (CAR) T-cell therapeutics that include idecabtagene vicleucel (bb2121) and JNJ-68284528.
- Published
- 2020
- Full Text
- View/download PDF
19. Immunotherapy of Multiple Myeloma: Promise and Challenges
- Author
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Hanley N. Abramson
- Subjects
Oncology ,medicine.medical_specialty ,medicine.medical_treatment ,Immunology ,chimeric antigen receptor t-cells ,antibody-drug conjugates ,Review ,bi-specific antibodies ,chemistry.chemical_compound ,Panobinostat ,Internal medicine ,medicine ,Immunology and Allergy ,Elotuzumab ,Multiple myeloma ,business.industry ,Bortezomib ,Daratumumab ,cytokine release syndrome ,Immunotherapy ,RC581-607 ,medicine.disease ,Pomalidomide ,Carfilzomib ,multiple myeloma ,chemistry ,monoclonal antibodies ,Immunologic diseases. Allergy ,business ,medicine.drug - Abstract
Hanley N Abramson Wayne State University, Department of Pharmaceutical Sciences, Detroit, MI, 48201, USACorrespondence: Hanley N AbramsonWayne State University, Department of Pharmaceutical Sciences, 259 Mack Ave, Detroit, Mi, 48201, USATel +1 248 420 5335Email ac2531@wayne.eduAbstract: Whereas the treatment of MM was dependent solely on alkylating agents and corticosteroids during the prior three decades, the landscape of therapeutic measures to treat the disease began to expand enormously early in the current century. The introduction of new classes of small-molecule drugs, such as proteasome blockers (bortezomib and carfilzomib), immunomodulators (lenalidomide and pomalidomide), nuclear export inhibitors (selinexor), and histone deacetylase blockers (panobinostat), as well as the application of autologous stem cell transplantation (ASCT), resulted in a seismic shift in how the disease is treated. The picture changed dramatically once again starting with the 2015 FDA approval of two monoclonal antibodies (mAbs) – the anti-CD38 daratumumab and the anti-SLAMF7 elotuzumab. Daratumumab, in particular, has had a great impact on MM therapy and today is often included in various regimens to treat the disease, both in newly diagnosed cases and in the relapse/refractory setting. Recently, other immunotherapies have been added to the arsenal of drugs available to fight this malignancy. These include isatuximab (also anti-CD38) and, in the past year, the antibody-drug conjugate (ADC) belantamab mafodotin and the chimeric antigen receptor (CAR) T-cell product idecabtagene vicleucel (ide-cel). While the accumulated benefits of these newer agents have resulted in a doubling of the disease’s five-year survival rate to more than 5 years and improved quality of life, the disease remains incurable. Almost without exception patients experience relapse and/or become refractory to the drugs used, making the search for innovative therapies all the more essential. This review covers the current scope of anti-myeloma immunotherapeutic agents, both those in clinical use and on the horizon, including naked mAbs, ADCs, bi- and multi-targeted mAbs, and CAR T-cells. Emphasis is placed on the benefits of each along with the challenges that need to be overcome if MM is to be considered curable in the future.Keywords: multiple myeloma, monoclonal antibodies, antibody-drug conjugates, bi-specific antibodies, chimeric antigen receptor T-cells, cytokine release syndrome
- Published
- 2021
20. Trends in tropical forest loss and the social value of emission reductions
- Author
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Knoke, T., Hanley, N., Roman-Cuesta, R. M., Groom, B., Venmans, F., and Paul, C.
- Subjects
ddc:630 ,ddc - Published
- 2022
21. Monoclonal Antibodies for the Treatment of Multiple Myeloma: An Update
- Author
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Hanley N. Abramson
- Subjects
myeloma ,daratumumab ,elotuzumab ,isatuximab ,CD38 ,JNJ-63723283 ,denosumab ,checkpoint inhibitors ,BCMA ,bispecific T-cell engager ,antibody-drug conjugates ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
The past two decades have seen a revolution in multiple myeloma (MM) therapy with the introduction of several small molecules, mostly orally effective, whose mechanisms are based on proteasome inhibition, histone deacetylase (HDAC) blockade, and immunomodulation. Immunotherapeutic approaches to MM treatment using monoclonal antibodies (mAbs), while long in development, began to reap success with the identification of CD38 and SLAMF7 as suitable targets for development, culminating in the 2015 Food and Drug Administration (FDA) approval of daratumumab and elotuzumab, respectively. This review highlights additional mAbs now in the developmental pipeline. Isatuximab, another anti-CD38 mAb, currently is under study in four phase III trials and may offer certain advantages over daratumumab. Several antibody-drug conjugates (ADCs) in the early stages of development are described, including JNJ-63723283, which has attained FDA breakthrough status for MM. Other mAbs described in this review include denosumab, recently approved for myeloma-associated bone loss, and checkpoint inhibitors, although the future status of the latter combined with immunomodulators has been clouded by unacceptably high death rates that caused the FDA to issue clinical holds on several of these trials. Also highlighted are the therapies based on the B Cell Maturation Antigen (BCMA), another very promising target for anti-myeloma development.
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- 2018
- Full Text
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22. INTRODUCTION : Science and policy mismatch in coastal zone ecosystem management
- Author
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Paterson, D. M., Hanley, N. D., Black, K., Defew, E. C., and Solan, M.
- Published
- 2011
23. Forum: Contrasting Approaches to Statistical Regression in Ecology and Economics
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Armsworth, P. R., Gaston, K. J., Hanley, N. D., and Ruffell, R. J.
- Published
- 2009
- Full Text
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24. Immunotherapy of Multiple Myeloma: Promise and Challenges
- Author
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Abramson,Hanley N
- Subjects
ImmunoTargets and Therapy - Abstract
Hanley N Abramson Wayne State University, Department of Pharmaceutical Sciences, Detroit, MI, 48201, USACorrespondence: Hanley N AbramsonWayne State University, Department of Pharmaceutical Sciences, 259 Mack Ave, Detroit, Mi, 48201, USATel +1 248 420 5335Email ac2531@wayne.eduAbstract: Whereas the treatment of MM was dependent solely on alkylating agents and corticosteroids during the prior three decades, the landscape of therapeutic measures to treat the disease began to expand enormously early in the current century. The introduction of new classes of small-molecule drugs, such as proteasome blockers (bortezomib and carfilzomib), immunomodulators (lenalidomide and pomalidomide), nuclear export inhibitors (selinexor), and histone deacetylase blockers (panobinostat), as well as the application of autologous stem cell transplantation (ASCT), resulted in a seismic shift in how the disease is treated. The picture changed dramatically once again starting with the 2015 FDA approval of two monoclonal antibodies (mAbs) â the anti-CD38 daratumumab and the anti-SLAMF7 elotuzumab. Daratumumab, in particular, has had a great impact on MM therapy and today is often included in various regimens to treat the disease, both in newly diagnosed cases and in the relapse/refractory setting. Recently, other immunotherapies have been added to the arsenal of drugs available to fight this malignancy. These include isatuximab (also anti-CD38) and, in the past year, the antibody-drug conjugate (ADC) belantamab mafodotin and the chimeric antigen receptor (CAR) T-cell product idecabtagene vicleucel (ide-cel). While the accumulated benefits of these newer agents have resulted in a doubling of the diseaseâs five-year survival rate to more than 5 years and improved quality of life, the disease remains incurable. Almost without exception patients experience relapse and/or become refractory to the drugs used, making the search for innovative therapies all the more essential. This review covers the current scope of anti-myeloma immunotherapeutic agents, both those in clinical use and on the horizon, including naked mAbs, ADCs, bi- and multi-targeted mAbs, and CAR T-cells. Emphasis is placed on the benefits of each along with the challenges that need to be overcome if MM is to be considered curable in the future.Keywords: multiple myeloma, monoclonal antibodies, antibody-drug conjugates, bi-specific antibodies, chimeric antigen receptor T-cells, cytokine release syndrome
- Published
- 2021
25. Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study
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Evans, Rachael A, primary, McAuley, Hamish, additional, Harrison, Ewen M, additional, Shikotra, Aarti, additional, Singapuri, Amisha, additional, Sereno, Marco, additional, Elneima, Omer, additional, Docherty, Annemarie B, additional, Lone, Nazir I, additional, Leavy, Olivia C, additional, Daines, Luke, additional, Baillie, J Kenneth, additional, Brown, Jeremy S, additional, Chalder, Trudie, additional, De Soyza, Anthony, additional, Diar Bakerly, Nawar, additional, Easom, Nicholas, additional, Geddes, John R, additional, Greening, Neil J, additional, Hart, Nick, additional, Heaney, Liam G, additional, Heller, Simon, additional, Howard, Luke, additional, Hurst, John R, additional, Jacob, Joseph, additional, Jenkins, R Gisli, additional, Jolley, Caroline, additional, Kerr, Steven, additional, Kon, Onn M, additional, Lewis, Keir, additional, Lord, Janet M, additional, McCann, Gerry P, additional, Neubauer, Stefan, additional, Openshaw, Peter J M, additional, Parekh, Dhruv, additional, Pfeffer, Paul, additional, Rahman, Najib M, additional, Raman, Betty, additional, Richardson, Matthew, additional, Rowland, Matthew, additional, Semple, Malcolm G, additional, Shah, Ajay M, additional, Singh, Sally J, additional, Sheikh, Aziz, additional, Thomas, David, additional, Toshner, Mark, additional, Chalmers, James D, additional, Ho, Ling-Pei, additional, Horsley, Alex, additional, Marks, Michael, additional, Poinasamy, Krisnah, additional, Wain, Louise V, additional, Brightling, Christopher E, additional, Abel, K, additional, Adamali, H, additional, Adeloye, D, additional, Adeyemi, O, additional, Adeyemi, F, additional, Ahmad, S, additional, Ahmed, R, additional, Ainsworth, M, additional, Alamoudi, A, additional, Aljaroof, M, additional, Allan, L, additional, Allen, R, additional, Alli, A, additional, Al-Sheklly, B, additional, Altmann, D, additional, Anderson, D, additional, Andrews, M, additional, Angyal, A, additional, Antoniades, C, additional, Arbane, G, additional, Armour, C, additional, Armstrong, N, additional, Armstrong, L, additional, Arnold, H, additional, Arnold, D, additional, Ashworth, M, additional, Ashworth, A, additional, Assefa-Kebede, H, additional, Atkin, P, additional, Atkins, H, additional, Atkins, A, additional, Aul, R, additional, Avram, C, additional, Baggott, R, additional, Baguley, D, additional, Baillie, J K, additional, Bain, S, additional, Bakali, M, additional, Bakau, M, additional, Baldry, E, additional, Baldwin, D, additional, Ballard, C, additional, Bambrough, J, additional, Barker, R E, additional, Barratt, S, additional, Barrett, F, additional, Basu, N, additional, Batterham, R, additional, Baxendale, H, additional, Bayes, H, additional, Bayley, M, additional, Beadsworth, M, additional, Beirne, P, additional, Bell, R, additional, Bell, D, additional, Berry, C, additional, Betts, S, additional, Bhui, K, additional, Bishop, L, additional, Blaikely, J, additional, Bloomfield, C, additional, Bloss, A, additional, Bolger, A, additional, Bolton, C E, additional, Bonnington, J, additional, Botkai, A, additional, Bourne, M, additional, Bourne, C, additional, Bradley, E, additional, Bramham, K, additional, Brear, L, additional, Breen, G, additional, Breeze, J, additional, Briggs, A, additional, Bright, E, additional, Brightling, C E, additional, Brill, S, additional, Brindle, K, additional, Broad, L, additional, Broome, M, additional, Brown, J S, additional, Brown, M, additional, Brown, J, additional, Brown, R, additional, Brown, V, additional, Brown, A, additional, Brugha, T, additional, Brunskill, N, additional, Buch, M, additional, Bularga, A, additional, Bullmore, E, additional, Burn, D, additional, Burns, G, additional, Busby, J, additional, Buttress, A, additional, Byrne, S, additional, Cairns, P, additional, Calder, P C, additional, Calvelo, E, additional, Card, B, additional, Carr, L, additional, Carson, G, additional, Carter, P, additional, Cavanagh, J, additional, Chalder, T, additional, Chalmers, J D, additional, Chambers, R C, additional, Channon, K, additional, Chapman, K, additional, Charalambou, A, additional, Chaudhuri, N, additional, Checkley, A, additional, Chen, J, additional, Chetham, L, additional, Chilvers, E R, additional, Chinoy, H, additional, Chong-James, K, additional, Choudhury, N, additional, Choudhury, G, additional, Chowdhury, P, additional, Chowienczyk, P, additional, Christie, C, additional, Clark, D, additional, Clark, C, additional, Clarke, J, additional, Clift, P, additional, Clohisey, S, additional, Coburn, Z, additional, Cole, J, additional, Coleman, C, additional, Connell, D, additional, Connolly, B, additional, Connor, L, additional, Cook, A, additional, Cooper, B, additional, Coupland, C, additional, Craig, T, additional, Crisp, P, additional, Cristiano, D, additional, Crooks, M G, additional, Cross, A, additional, Cruz, I, additional, Cullinan, P, additional, Daines, L, additional, Dalton, M, additional, Dark, P, additional, Dasgin, J, additional, David, A, additional, David, C, additional, Davies, M, additional, Davies, G, additional, Davies, K, additional, Davies, F, additional, Davies, G A, additional, Daynes, E, additional, De Silva, T, additional, De Soyza, A, additional, Deakin, B, additional, Deans, A, additional, Defres, S, additional, Dell, A, additional, Dempsey, K, additional, Dennis, J, additional, Dewar, A, additional, Dharmagunawardena, R, additional, Diar Bakerly, N, additional, Dipper, A, additional, Diver, S, additional, Diwanji, S N, additional, Dixon, M, additional, Djukanovic, R, additional, Dobson, H, additional, Dobson, C, additional, Dobson, S L, additional, Docherty, A B, additional, Donaldson, A, additional, Dong, T, additional, Dormand, N, additional, Dougherty, A, additional, Dowling, R, additional, Drain, S, additional, Dulawan, P, additional, Dunn, S, additional, Easom, N, additional, Echevarria, C, additional, Edwards, S, additional, Edwardson, C, additional, Elliott, B, additional, Elliott, A, additional, Ellis, Y, additional, Elmer, A, additional, Elneima, O, additional, Evans, R A, additional, Evans, J, additional, Evans, H, additional, Evans, D, additional, Evans, R I, additional, Evans, R, additional, Evans, T, additional, Fabbri, L, additional, Fairbairn, S, additional, Fairman, A, additional, Fallon, K, additional, Faluyi, D, additional, Favager, C, additional, Felton, T, additional, Finch, J, additional, Finney, S, additional, Fisher, H, additional, Fletcher, S, additional, Flockton, R, additional, Foote, D, additional, Ford, A, additional, Forton, D, additional, Francis, R, additional, Francis, S, additional, Francis, C, additional, Frankel, A, additional, Fraser, E, additional, Free, R, additional, French, N, additional, Fuld, J, additional, Furniss, J, additional, Garner, L, additional, Gautam, N, additional, Geddes, J R, additional, George, P M, additional, George, J, additional, Gibbons, M, additional, Gilmour, L, additional, Gleeson, F, additional, Glossop, J, additional, Glover, S, additional, Goodman, N, additional, Gooptu, B, additional, Gorsuch, T, additional, Gourlay, E, additional, Greenhaff, P, additional, Greenhalf, W, additional, Greenhalgh, A, additional, Greening, N J, additional, Greenwood, J, additional, Greenwood, S, additional, Gregory, R, additional, Grieve, D, additional, Gummadi, M, additional, Gupta, A, additional, Gurram, S, additional, Guthrie, E, additional, Hadley, K, additional, Haggar, A, additional, Hainey, K, additional, Haldar, P, additional, Hall, I, additional, Hall, L, additional, Halling-Brown, M, additional, Hamil, R, additional, Hanley, N A, additional, Hardwick, H, additional, Hardy, E, additional, Hargadon, B, additional, Harrington, K, additional, Harris, V, additional, Harrison, E M, additional, Harrison, P, additional, Hart, N, additional, Harvey, A, additional, Harvey, M, additional, Harvie, M, additional, Havinden-Williams, M, additional, Hawkes, J, additional, Hawkings, N, additional, Haworth, J, additional, Hayday, A, additional, Heaney, L G, additional, Heeney, J L, additional, Heightman, M, additional, Heller, S, additional, Henderson, M, additional, Hesselden, L, additional, Hillman, T, additional, Hingorani, A, additional, Hiwot, T, additional, Ho, L P, additional, Hoare, A, additional, Hoare, M, additional, Hogarth, P, additional, Holbourn, A, additional, Holdsworth, L, additional, Holgate, D, additional, Holmes, K, additional, Holroyd-Hind, B, additional, Horsley, A, additional, Hosseini, A, additional, Hotopf, M, additional, Houchen, L, additional, Howard, L, additional, Howell, A, additional, Hufton, E, additional, Hughes, A, additional, Hughes, J, additional, Hughes, R, additional, Humphries, A, additional, Huneke, N, additional, Hurst, J R, additional, Hurst, R, additional, Husain, M, additional, Hussell, T, additional, Ibrahim, W, additional, Ient, A, additional, Ingram, L, additional, Ismail, K, additional, Jackson, T, additional, Jacob, J, additional, James, W Y, additional, Janes, S, additional, Jarvis, H, additional, Jayaraman, B, additional, Jenkins, R G, additional, Jezzard, P, additional, Jiwa, K, additional, Johnson, S, additional, Johnson, C, additional, Johnston, D, additional, Jolley, C, additional, Jolley, C J, additional, Jones, I, additional, Jones, S, additional, Jones, D, additional, Jones, H, additional, Jones, G, additional, Jones, M, additional, Jose, S, additional, Kabir, T, additional, Kaltsakas, G, additional, Kamwa, V, additional, Kar, P, additional, Kausar, Z, additional, Kelly, S, additional, Kerr, S, additional, Key, A L, additional, Khan, F, additional, Khunti, K, additional, King, C, additional, King, B, additional, Kitterick, P, additional, Klenerman, P, additional, Knibbs, L, additional, Knight, S, additional, Knighton, A, additional, Kon, O M, additional, Kon, S, additional, Kon, S S, additional, Korszun, A, additional, Kotanidis, C, additional, Koychev, I, additional, Kurupati, P, additional, Kwan, J, additional, Laing, C, additional, Lamlum, H, additional, Landers, G, additional, Langenberg, C, additional, Lasserson, D, additional, Lawrie, A, additional, Lea, A, additional, Leavy, O C, additional, Lee, D, additional, Lee, E, additional, Leitch, K, additional, Lenagh, R, additional, Lewis, K, additional, Lewis, V, additional, Lewis, K E, additional, Lewis, J, additional, Lewis-Burke, N, additional, Light, T, additional, Lightstone, L, additional, Lim, L, additional, Linford, S, additional, Lingford-Hughes, A, additional, Lipman, M, additional, Liyanage, K, additional, Lloyd, A, additional, Logan, S, additional, Lomas, D, additional, Lone, N I, additional, Loosley, R, additional, Lord, J M, additional, Lota, H, additional, Lucey, A, additional, MacGowan, G, additional, Macharia, I, additional, Mackay, C, additional, Macliver, L, additional, Madathil, S, additional, Madzamba, G, additional, Magee, N, additional, Mairs, N, additional, Majeed, N, additional, Major, E, additional, Malim, M, additional, Mallison, G, additional, Man, W, additional, Mandal, S, additional, Mangion, K, additional, Mansoori, P, additional, Marciniak, S, additional, Mariveles, M, additional, Marks, M, additional, Marshall, B, additional, Martineau, A, additional, Maskell, N, additional, Matila, D, additional, Matthews, L, additional, Mayet, J, additional, McAdoo, S, additional, McAllister-Williams, H, additional, McArdle, P, additional, McArdle, A, additional, McAulay, D, additional, McAuley, H, additional, McAuley, D F, additional, McCafferty, K, additional, McCann, G P, additional, McCauley, H, additional, McCourt, P, additional, Mcgarvey, L, additional, McGinness, J, additional, McGovern, A, additional, McGuinness, H, additional, McInnes, I B, additional, McIvor, K, additional, McIvor, E, additional, McMahon, A, additional, McMahon, M J, additional, McMorrow, L, additional, Mcnally, T, additional, McNarry, M, additional, McQueen, A, additional, McShane, H, additional, Megson, S, additional, Meiring, J, additional, Menzies, D, additional, Michael, A, additional, Milligan, L, additional, Mills, N, additional, Mitchell, J, additional, Mohamed, A, additional, Molyneaux, P L, additional, Monteiro, W, additional, Morley, A, additional, Morrison, L, additional, Morriss, R, additional, Morrow, A, additional, Moss, A, additional, Moss, A J, additional, Moss, P, additional, Mukaetova-Ladinska, E, additional, Munawar, U, additional, Murali, E, additional, Murira, J, additional, Nassa, H, additional, Neill, P, additional, Neubauer, S, additional, Newby, D, additional, Newell, H, additional, Newton Cox, A, additional, Nicholson, T, additional, Nicoll, D, additional, Nolan, C M, additional, Noonan, M J, additional, Novotny, P, additional, Nunag, J, additional, Nyaboko, J, additional, O'Brien, L, additional, Odell, N, additional, Ogg, G, additional, Olaosebikan, O, additional, Oliver, C, additional, Omar, Z, additional, Openshaw, P J M, additional, Rivera-Ortega, P, additional, Osbourne, R, additional, Ostermann, M, additional, Overton, C, additional, Oxton, J, additional, Pacpaco, E, additional, Paddick, S, additional, Papineni, P, additional, Paradowski, K, additional, Pareek, M, additional, Parekh, D, additional, Parfrey, H, additional, Pariante, C, additional, Parker, S, additional, Parkes, M, additional, Parmar, J, additional, Parvin, R, additional, Patale, S, additional, Patel, B, additional, Patel, S, additional, Patel, M, additional, Pathmanathan, B, additional, Pavlides, M, additional, Pearl, J E, additional, Peckham, D, additional, Pendlebury, J, additional, Peng, Y, additional, Pennington, C, additional, Peralta, I, additional, Perkins, E, additional, Peto, T, additional, Petousi, N, additional, Petrie, J, additional, Pfeffer, P, additional, Phipps, J, additional, Pimm, J, additional, Piper Hanley, K, additional, Pius, R, additional, Plein, S, additional, Plekhanova, T, additional, Poinasamy, K, additional, Polgar, O, additional, Poll, L, additional, Porter, J C, additional, Portukhay, S, additional, Powell, N, additional, Price, L, additional, Price, D, additional, Price, A, additional, Price, C, additional, Prickett, A, additional, Quaid, S, additional, Quigley, J, additional, Quint, J, additional, Qureshi, H, additional, Rahman, N, additional, Rahman, M, additional, Ralser, M, additional, Raman, B, additional, Ramos, A, additional, Rangeley, J, additional, Rees, T, additional, Regan, K, additional, Richards, A, additional, Richardson, M, additional, Robertson, E, additional, Rodgers, J, additional, Ross, G, additional, Rossdale, J, additional, Rostron, A, additional, Routen, A, additional, Rowland, A, additional, Rowland, M J, additional, Rowland, J, additional, Rowland-Jones, S L, additional, Roy, K, additional, Rudan, I, additional, Russell, R, additional, Russell, E, additional, Sabit, R, additional, Sage, E K, additional, Samani, N, additional, Samuel, R, additional, Sapey, E, additional, Saralaya, D, additional, Saratzis, A, additional, Sargeant, J, additional, Sass, T, additional, Sattar, N, additional, Saunders, K, additional, Saunders, R, additional, Saxon, W, additional, Sayer, A, additional, Schwaeble, W, additional, Scott, J, additional, Scott, K, additional, Selby, N, additional, Semple, M G, additional, Sereno, M, additional, Shah, K, additional, Shah, A, additional, Shah, P, additional, Sharma, M, additional, Sharpe, M, additional, Sharpe, C, additional, Shaw, V, additional, Sheikh, A, additional, Shevket, K, additional, Shikotra, A, additional, Short, J, additional, Siddiqui, S, additional, Sigfrid, L, additional, Simons, G, additional, Simpson, J, additional, Singapuri, A, additional, Singh, S J, additional, Singh, C, additional, Singh, S, additional, Skeemer, J, additional, Smith, I, additional, Smith, J, additional, Smith, L, additional, Smith, A, additional, Soares, M, additional, Southern, D, additional, Spears, M, additional, Spencer, L G, additional, Speranza, F, additional, Stadon, L, additional, Stanel, S, additional, Steiner, M, additional, Stensel, D, additional, Stern, M, additional, Stewart, I, additional, Stockley, J, additional, Stone, R, additional, Storrie, A, additional, Storton, K, additional, Stringer, E, additional, Subbe, C, additional, Sudlow, C, additional, Suleiman, Z, additional, Summers, C, additional, Summersgill, C, additional, Sutherland, D, additional, Sykes, D L, additional, Sykes, R, additional, Talbot, N, additional, Tan, A L, additional, Taylor, C, additional, Taylor, A, additional, Te, A, additional, Tedd, H, additional, Tee, C J, additional, Tench, H, additional, Terry, S, additional, Thackray-Nocera, S, additional, Thaivalappil, F, additional, Thickett, D, additional, Thomas, D, additional, Thomas, D C, additional, Thomas, A K, additional, Thompson, A A R, additional, Thompson, T, additional, Thornton, T, additional, Thwaites, R S, additional, Tobin, M, additional, Toingson, G F, additional, Tong, C, additional, Toshner, M, additional, Touyz, R, additional, Tripp, K A, additional, Tunnicliffe, E, additional, Turner, E, additional, Turtle, L, additional, Turton, H, additional, Ugwuoke, R, additional, Upthegrove, R, additional, Valabhji, J, additional, Vellore, K, additional, Wade, E, additional, Wain, L V, additional, Wajero, L O, additional, Walder, S, additional, Walker, S, additional, Wall, E, additional, Wallis, T, additional, Walmsley, S, additional, Walsh, S, additional, Walsh, J A, additional, Watson, L, additional, Watson, J, additional, Watson, E, additional, Welch, C, additional, Welch, H, additional, Welsh, B, additional, Wessely, S, additional, West, S, additional, Wheeler, H, additional, Whitehead, V, additional, Whitney, J, additional, Whittaker, S, additional, Whittam, B, additional, Wild, J, additional, Wilkins, M, additional, Wilkinson, D, additional, Williams, N, additional, Williams, B, additional, Williams, J, additional, Williams-Howard, S A, additional, Willicombe, M, additional, Willis, G, additional, Wilson, D, additional, Wilson, I, additional, Window, N, additional, Witham, M, additional, Wolf-Roberts, R, additional, Woodhead, F, additional, Woods, J, additional, Wootton, D, additional, Worsley, J, additional, Wraith, D, additional, Wright, L, additional, Wright, C, additional, Wright, S, additional, Xie, C, additional, Yasmin, S, additional, Yates, T, additional, Yip, K P, additional, Young, B, additional, Young, S, additional, Young, A, additional, Yousuf, A J, additional, Yousuf, A, additional, Zawia, A, additional, Zhao, B, additional, and Zongo, O, additional
- Published
- 2021
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26. A comparison of citizen and “expert” preferences using an attribute-based approach to choice
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Colombo, S., Angus, A., Morris, J., Parsons, D.J., Brawn, M., Stacey, K., and Hanley, N.
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- 2009
- Full Text
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27. The stress of starvation: glucocorticoid restraint of beta cell development
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Matthews, L. C. and Hanley, N. A.
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- 2011
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28. Emerging Monoclonal Antibodies for the Treatment of Multiple Myeloma
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Hanley N. Abramson
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medicine.drug_class ,business.industry ,InformationSystems_INFORMATIONSTORAGEANDRETRIEVAL ,medicine.disease ,Monoclonal antibody ,03 medical and health sciences ,0302 clinical medicine ,030220 oncology & carcinogenesis ,medicine ,Cancer research ,business ,GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries) ,Multiple myeloma ,030215 immunology - Abstract
Therapeutic measures designed to treat multiple myeloma (MM) have undergone a fundamental shift over the past two decades as a number of small molecules that attack this cancer by different mechanisms, including proteasome blockade, immunomodulation, and histone deacetylase (HDAC) inhibition, have been introduced. The insertion of monoclonal antibodies (mAbs) into the mix began in 2015 with the U.S. Food and Drug Administration (FDA) approval of daratumumab and elotuzumab, which target CD38 and SLAMF7, respectively. In 2020, they were joined by another anti-CD38 mAb, isatuximab, and the bispecific antibody-drug conjugate (ADC) belantamab mafodotin, which targets the B-cell maturation antigen (BCMA). This review focuses on additional mAbs currently under clinical study for MM. These include several BCMAxCD3-directed bispecifics (AMG 420, AMG 701, REGN5458, REGN5459, teclistamab, and TNB-383B), the ADCs indatuximab ravtansine and STRO-001, and checkpoint inhibitors, although the future status of the latter is in a state of flux due to toxicity issues that arose in trials in which these drugs, especially PD-1 or PD-L1 blockers, were combined with immunomodulators.
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- 2020
29. Allowing for Participants in Royal Commissions: A Scoping Review
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McDonald, D, Carpenter, J, Hanley, N, McDonald, D, Carpenter, J, and Hanley, N
- Abstract
This article examines Royal Commissions on the basis of participant experiences. Comprising individuals or groups whose experiences and insights are central to the work of a Royal Commission, they may appear due to their status as victims of crime, and/or in a professional or witness capacity. As a growing number of Royal Commissions have sought to emphasise participant experiences of harm, it is important to understand how individuals engage with and experience them. Barriers impacting participants in traditional criminal justice processes have been well documented, and participation in Royal Commissions has been a matter of emerging interest academically. However, these domains have not yet overlapped. This article seeks to address this oversight by drawing out in more explicit detail what is and is not known about barriers to participation in Royal Commissions. Examination of participant experiences can provide useful lessons for future inquiries; it may foster greater confidence among affected communities and thereby augment an inquiry’s public legitimacy.
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- 2020
30. Environmental Cost–Benefit Analysis
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Hanley, N., primary
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- 2013
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31. Human Pluripotent Stem Cells for Modeling Toxicity
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Sison-Young, R.L.C., primary, Kia, R., additional, Heslop, J., additional, Kelly, L., additional, Rowe, C., additional, Cross, M.J., additional, Kitteringham, N.R., additional, Hanley, N., additional, Park, B.K., additional, and Goldring, C.E.P., additional
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- 2012
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32. The economic benefits of soil erosion control: an application of the contingent valuation method in the Alto Genil basin of southern Spain
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Colombo, S., Calatrava-Requena, J., and Hanley, N.
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Soil erosion -- Research - Abstract
The soil erosion process has been widely studied from a technical point of view. There are many papers that consider the importance of the physical characteristics of soils and climatic […]
- Published
- 2003
33. B-Cell Maturation Antigen (BCMA) as a Target for New Drug Development in Relapsed and/or Refractory Multiple Myeloma
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Abramson, Hanley N., primary
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- 2020
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34. Re: Letter to the Editor of Public Health in response to 'Willingness to pay for policies to reduce future deaths from climate change: evidence from a British survey'
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Graham, H., primary, de Bell, S., additional, Hanley, N., additional, Jarvis, S., additional, and White, P.C.L., additional
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- 2020
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35. An economic analysis of agricultural externalities with special reference to straw-burning
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Hanley, N. D.
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338.1 ,Farming costs and environment - Published
- 1986
36. Bone marrow-derived cells and the vasculature in diabetes: from biomarker to treatment?
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Hanley, N. A.
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- 2007
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37. Use of Gene Expression Analysis Incorporating Operon-Transcriptional Coupling and Toxicant Dose Response to Distinguish Among Structural Homologues of MX.: 29
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Ward, B, Swartz, C, Hanley, N, Warren, S, and DeMarini, D.
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- 2007
38. Glucagon-Like Peptide-1 (GLP1) signalling stimulates human beta-cell differentiation: support for increasing beta-cell numbers in Type 2 diabetes: A30
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Hanley, K Piper, Gray, S, Dijkstra, I ME, Williams, L, Wilson, D I, Hearn, T, and Hanley, N A
- Published
- 2007
39. Human embryo and early fetus research
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Ostrer, H, Wilson, D I, and Hanley, N A
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- 2006
40. Policy on agricultural pollution in the European Union.
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Hanley, N., primary
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- 2001
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41. Characterization and plasticity of human fetal-derived cartilage cells - implications for skeletal tissue regeneration
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Mirmalek-Sani, S. H., Roach, H. I., Hanley, N. A., Wilson, D. I., and Oreffo, R. O.C.
- Published
- 2005
42. Beta-cell differentiation during human development does not rely on nestin-positive precursors: implications for stem cell-derived replacement therapy
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Piper, K., Ball, S. G., Turnpenny, L. W., Brickwood, S., Wilson, D. I., and Hanley, N. A.
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- 2002
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43. Economic instruments and waste minimization: the need for discard-relevant and purchase-relevant instruments
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Fenton, R. and Hanley, N.
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England -- Environmental policy ,Waste minimization -- Planning ,Environmental issues - Abstract
England's pollution reduction policies should encompass a mix of tactics to alter behavior at the point of purchase and at the point of discard to reduce waste without imposing economic costs that are overly burdensome. The economic instruments available include fees based on amount of refuse, levies on certain products, recycling credits, refunds on levied products and shifting disposal responsibility to producers. These methods can be characterized based on whether they focus on purchase decisions or discard obligations.
- Published
- 1995
44. Wolcott-Rallison syndrome: pathogenic insights into neonatal diabetes from new mutation and expression studies of EIF2AK3
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Brickwood, S, Bonthron, D T, Al-Gazali, L I, Piper, K, Hearn, T, Wilson, D I, and Hanley, N A
- Published
- 2003
45. Genes, mice and the internet: is WT1 the shape of things to come?*
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Hanley, N. A. and Ball, S. G.
- Published
- 2000
46. Survival in a case of life-threatening flecainide overdose
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Hanley, N. A., Bourke, J. P., and Gascoigne, A. D.
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- 1998
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47. Why is more notice not taken of economists' prescriptions for the control of pollution?
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Hanley, N., Hallet, S., and Moffatt, I.
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Environmental economics -- Laws, regulations and rules ,Pollution -- Control ,Environmental policy -- Economic aspects ,Economists -- Environmental policy ,Environmental issues - Abstract
This paper is concerned with trying to explain why governments have not taken more notice of economists' suggestions with respect to pollution control policy. Four possible explanations are considered: ignorance; theoretical problems; practical problems; and institutional or cultural factors. It is concluded that economists have been too narrow in their focus on efficiency as an appropriate objective function for legislators and pressure groups, and that there are numerous problems associated with bringing in incentive-based policies for the control of pollution. However, the basic attraction of such policies--that by permitting flexibility in emission reductions across sources, cost savings are made possible--remains sufficiently strong to warrant more research attention being given to modelling such policies in specific situations.
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- 1990
48. The effects of variation in management objectives on responses to invading diseases under uncertainty: Forest Pathogens
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Dangerfield, C.E., Whalley, A.E., Hanley, N., Healey, J.R., and Gilligan, C.A.
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Agricultural and Food Policy - Abstract
The real options approach provides a powerful tool for determining the optimal time at which to adopt disease control measures given uncertainty about the future spread of an invading pest/pathogen. We consider the management of disease invasions in the natural environment typified by woodlands. Previous studies considered the timing of control from the point of view of a central planner, for example a governmental decision making body. However, decisions regarding the deployment of control measures in the landscape are typically taken by individual land managers. Woodlands provide both marketable benefits, such as timber, and non-marketable benefits, for example biodiversity. The relative importance placed on these types of benefit depends on the land purpose, which is determined by a managers’ objectives. We investigate how management objectives influence the optimal timing of control adoption. Our results show that differences in objectives lead managers to exercise the option to control at different times, and potentially never adopt disease control. Since infection can spread from one region to another, managers who do not adopt control therefore transfer the risk of infection to other managers within the landscape. For landscapes composed of managers with divergent objectives, this creates conflict due to the transferable externality (the disease). We show targeted subsidies can reduce differences in the timing of control adoption between managers with divergent objectives. Both lump-sum subsidies and annual subsidies bring forward the adoption of control strategies, causing them to be implemented over a wider range of infection proportions in an individual woodland. However, the two types of subsidy have opposite effects on the decision to suspend control. Annual subsidies delay suspension and extend the region over which control continues to be implemented. In contrast, lump-sum subsidies slightly reduce the region over which control continues to be implemented. For high proportions of infection, this implies that a lump-sum subsidy can induce a value-maximising manager to suspend control earlier: the opposite effect to that presumably intended. Our results have important implications for national decision making bodies and suggest that incentives may need to be targeted at specific groups to ensure a coherent response to disease control.
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- 2018
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49. Modelling sustainable development: systems dynamic and input–ouput approaches
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Moffatt, I and Hanley, N
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- 2001
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50. Modelling the transfer of the socio-economic benefits of environmental management
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Oglethorpe, David, Hanley, N., Hussain, S., and Sanderson, R.
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- 2000
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