1,447 results on '"Hanley, Daniel F"'
Search Results
2. Research considerations for prospective studies of patients with coma and disorders of consciousness
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Tinti, Lorenzo, Lawson, Thomas, Molteni, Erika, Kondziella, Daniel, Rass, Verena, Sharshar, Tarek, Bodien, Yelena G, Giacino, Joseph T, Mayer, Stephan A, Amiri, Moshgan, Muehlschlegel, Susanne, Rao, Chethan P Venkatasubba, Vespa, Paul M, Menon, David K, Citerio, Giuseppe, Helbok, Raimund, McNett, Molly, Agarwal, Sachin, Aiyagari, Venkatesh, Akbari, Yama, Albertson, Asher, Alexander, Sheila, Alexandrov, Anne, Alkhachroum, Ayham, Al-Mufti, Fawaz, Amiri, Moshagan, Appavu, Brian, Gebrewold, Meron Awraris, Ayounb, Marc, Badenes, Rafael, Bader, Mary Kay, Badjiata, Neeraj, Balu, Ram, Barlow, Brooke, Barra, Megan, Beekman, Rachel, Beghi, Ettore, Beqiri, Erta, Berlin, Tracey, Bilotta, Federico, Bleck, Thomas, Bodien, Yelena, Boerwinkle, Varina, Boly, Melanie, Bonnel, Alexandra, Brazzi, Luca, Brown, Emery, Bulic, Sebina, Caceres, Eder, Caceres, Adrian, Cafiero, Tullio, Carroll, Elizabeth, Cediel, Emilio G, Chou, Sherry, Claassen, Jan, Condie, Chad, Conti, Alfredo, Cosmas, Katie, Costa, Paolo, Creutzfeldt, Claire, Dangayach, Neha, Dauri, Mario, Debicki, Derek, DeGeorgia, Michael, Der-Nigoghossian, Caroline, Desai, Masoom, Dhar, Rajat, Diringer, Michael, Durr, Emily, Edlow, Brian, Ercole, Ari, Estraneo, Anna, Falcone, Guido, Farrokh, Salia, Ferguson, Adam, Fernandez-Espejo, Davinia, Fink, Ericka, Fins, Joseph, Foreman, Brandon, Franchi, Federico, Frontera, Jennifer, Ganesan, Rishi, Gaspard, Nicolas, Ghavam, Ahmeneh, Giacino, Joseph, Gibbons, Christie, Gilmore, Emily, Glustein, Chavie, Gosseries, Olivia, Green, Theresa, Greer, David, Guanci, Mary, Gupta, Deepak, Hahn, Cecil, Hakimi, Ryan, Hammond, Flora, Hanley, Daniel F, Hartings, Jed, and Hassan, Ahmed
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Biological Psychology ,Biomedical and Clinical Sciences ,Psychology ,Neurosciences ,Brain Disorders ,Prevention ,Curing Coma Campaign Collaborators ,coma ,design ,disorders of consciousness ,outcomes ,prospective studies ,Clinical sciences ,Biological psychology - Abstract
Disorders of consciousness are neurological conditions characterized by impaired arousal and awareness of self and environment. Behavioural responses are absent or are present but fluctuate. Disorders of consciousness are commonly encountered as a consequence of both acute and chronic brain injuries, yet reliable epidemiological estimates would require inclusive, operational definitions of the concept, as well as wider knowledge dissemination among involved professionals. Whereas several manifestations have been described, including coma, vegetative state/unresponsive wakefulness syndrome and minimally conscious state, a comprehensive neurobiological definition for disorders of consciousness is still lacking. The scientific literature is primarily observational, and studies-specific aetiologies lead to disorders of consciousness. Despite advances in these disease-related forms, there remains uncertainty about whether disorders of consciousness are a disease-agnostic unitary entity with a common mechanism, prognosis or treatment response paradigm. Our knowledge of disorders of consciousness has also been hampered by heterogeneity of study designs, variables, and outcomes, leading to results that are not comparable for evidence synthesis. The different backgrounds of professionals caring for patients with disorders of consciousness and the different goals at different stages of care could partly explain this variability. The Prospective Studies working group of the Neurocritical Care Society Curing Coma Campaign was established to create a platform for observational studies and future clinical trials on disorders of consciousness and coma across the continuum of care. In this narrative review, the author panel presents limitations of prior observational clinical research and outlines practical considerations for future investigations. A narrative review format was selected to ensure that the full breadth of study design considerations could be addressed and to facilitate a future consensus-based statement (e.g. via a modified Delphi) and series of recommendations. The panel convened weekly online meetings from October 2021 to December 2022. Research considerations addressed the nosographic status of disorders of consciousness, case ascertainment and verification, selection of dependent variables, choice of covariates and measurement and analysis of outcomes and covariates, aiming to promote more homogeneous designs and practices in future observational studies. The goal of this review is to inform a broad community of professionals with different backgrounds and clinical interests to address the methodological challenges imposed by the transition of care from acute to chronic stages and to streamline data gathering for patients with disorders of consciousness. A coordinated effort will be a key to allow reliable observational data synthesis and epidemiological estimates and ultimately inform condition-modifying clinical trials.
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- 2023
3. Clinical Trial Protocol for BEACH: A Phase 2a Study of MW189 in Patients with Acute Nontraumatic Intracerebral Hemorrhage
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Avadhani, Radhika, Ziai, Wendy C., Thompson, Richard E., Mould, W. Andrew, Lane, Karen, Nanni, Angeline, Iacobelli, Michael, Sharrock, Matthew F., Sansing, Lauren H., Van Eldik, Linda J., and Hanley, Daniel F.
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- 2024
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4. Association Between Neutrophil–Lymphocyte Ratio and 30-Day Infection and Thrombotic Outcomes After Intraventricular Hemorrhage: A CLEAR III Analysis
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Kaleem, Safa, Zhang, Cenai, Gusdon, Aaron M., Oh, Stephanie, Merkler, Alexander E., Avadhani, Radhika, Awad, Isaam, Hanley, Daniel F., Kamel, Hooman, Ziai, Wendy C., and Murthy, Santosh B.
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- 2024
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5. Optimal Design of Clinical Trials Involving Persons with Disorders of Consciousness
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Cho, Sung-Min, Robba, Chiara, Diringer, Michael N., Hanley, Daniel F., Hemphill, J. Claude, Horn, Janneke, Lewis, Ariane, Livesay, Sarah L., Menon, David, Sharshar, Tarek, Stevens, Robert D., Torner, James, Vespa, Paul M., Ziai, Wendy C., Spann, Marcus, Helbok, Raimund, and Suarez, Jose I.
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- 2024
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6. Trends in performance of thrombectomy for acute ischemic stroke patients in teaching and non-teaching hospitals
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Qureshi, Adnan I., Bhatti, Ibrahim A., Gomez, Camilo R., Hanley, Daniel F., Ford, Daniel E., Hassan, Ameer E., Nguyen, Thanh N., Spiotta, Alejandro M., and Kwok, Chun Shing
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- 2024
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7. Early Outpatient Treatment for Covid-19 with Convalescent Plasma
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Sullivan, David J, Gebo, Kelly A, Shoham, Shmuel, Bloch, Evan M, Lau, Bryan, Shenoy, Aarthi G, Mosnaim, Giselle S, Gniadek, Thomas J, Fukuta, Yuriko, Patel, Bela, Heath, Sonya L, Levine, Adam C, Meisenberg, Barry R, Spivak, Emily S, Anjan, Shweta, Huaman, Moises A, Blair, Janis E, Currier, Judith S, Paxton, James H, Gerber, Jonathan M, Petrini, Joann R, Broderick, Patrick B, Rausch, William, Cordisco, Marie-Elena, Hammel, Jean, Greenblatt, Benjamin, Cluzet, Valerie C, Cruser, Daniel, Oei, Kevin, Abinante, Matthew, Hammitt, Laura L, Sutcliffe, Catherine G, Forthal, Donald N, Zand, Martin S, Cachay, Edward R, Raval, Jay S, Kassaye, Seble G, Foster, E Colin, Roth, Michael, Marshall, Christi E, Yarava, Anusha, Lane, Karen, McBee, Nichol A, Gawad, Amy L, Karlen, Nicky, Singh, Atika, Ford, Daniel E, Jabs, Douglas A, Appel, Lawrence J, Shade, David M, Ehrhardt, Stephan, Baksh, Sheriza N, Laeyendecker, Oliver, Pekosz, Andrew, Klein, Sabra L, Casadevall, Arturo, Tobian, Aaron AR, and Hanley, Daniel F
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Biomedical and Clinical Sciences ,Clinical Sciences ,Clinical Research ,Clinical Trials and Supportive Activities ,Neurodegenerative ,Patient Safety ,6.1 Pharmaceuticals ,Evaluation of treatments and therapeutic interventions ,Adult ,Ambulatory Care ,COVID-19 ,Disease Progression ,Double-Blind Method ,Hospitalization ,Humans ,Immunization ,Passive ,Treatment Outcome ,United States ,COVID-19 Serotherapy ,Medical and Health Sciences ,General & Internal Medicine ,Biomedical and clinical sciences ,Health sciences - Abstract
BackgroundPolyclonal convalescent plasma may be obtained from donors who have recovered from coronavirus disease 2019 (Covid-19). The efficacy of this plasma in preventing serious complications in outpatients with recent-onset Covid-19 is uncertain.MethodsIn this multicenter, double-blind, randomized, controlled trial, we evaluated the efficacy and safety of Covid-19 convalescent plasma, as compared with control plasma, in symptomatic adults (≥18 years of age) who had tested positive for severe acute respiratory syndrome coronavirus 2, regardless of their risk factors for disease progression or vaccination status. Participants were enrolled within 8 days after symptom onset and received a transfusion within 1 day after randomization. The primary outcome was Covid-19-related hospitalization within 28 days after transfusion.ResultsParticipants were enrolled from June 3, 2020, through October 1, 2021. A total of 1225 participants underwent randomization, and 1181 received a transfusion. In the prespecified modified intention-to-treat analysis that included only participants who received a transfusion, the primary outcome occurred in 17 of 592 participants (2.9%) who received convalescent plasma and 37 of 589 participants (6.3%) who received control plasma (absolute risk reduction, 3.4 percentage points; 95% confidence interval, 1.0 to 5.8; P = 0.005), which corresponded to a relative risk reduction of 54%. Evidence of efficacy in vaccinated participants cannot be inferred from these data because 53 of the 54 participants with Covid-19 who were hospitalized were unvaccinated and 1 participant was partially vaccinated. A total of 16 grade 3 or 4 adverse events (7 in the convalescent-plasma group and 9 in the control-plasma group) occurred in participants who were not hospitalized.ConclusionsIn participants with Covid-19, most of whom were unvaccinated, the administration of convalescent plasma within 9 days after the onset of symptoms reduced the risk of disease progression leading to hospitalization. (Funded by the Department of Defense and others; CSSC-004 ClinicalTrials.gov number, NCT04373460.).
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- 2022
8. How do I implement an outpatient program for the administration of convalescent plasma for COVID‐19?
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Bloch, Evan M, Tobian, Aaron AR, Shoham, Shmuel, Hanley, Daniel F, Gniadek, Thomas J, Cachay, Edward R, Meisenberg, Barry R, Kafka, Kimberly, Marshall, Christi, Heath, Sonya L, Shenoy, Aarthi, Paxton, James H, Levine, Adam, Forthal, Donald, Fukuta, Yuriko, Huaman, Moises A, Ziman, Alyssa, Adamski, Jill, Gerber, Jonathan, Cruser, Daniel, Kassaye, Seble G, Mosnaim, Giselle S, Patel, Bela, Metcalf, Ryan A, Anjan, Shweta, Reisler, Ronald B, Yarava, Anusha, Lane, Karen, McBee, Nichol, Gawad, Amy, Raval, Jay S, Zand, Martin, Abinante, Matthew, Broderick, Patrick B, Casadevall, Arturo, Sullivan, David, and Gebo, Kelly A
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Emerging Infectious Diseases ,Prevention ,Infectious Diseases ,Good Health and Well Being ,COVID-19 ,Humans ,Immunization ,Passive ,Outpatients ,Pandemics ,SARS-CoV-2 ,United States ,COVID-19 Serotherapy ,ambulatory care ,antibodies ,blood transfusion ,COVID-19 serotherapy ,monoclonal ,plasma ,Cardiorespiratory Medicine and Haematology ,Clinical Sciences ,Immunology ,Cardiovascular System & Hematology - Abstract
Convalescent plasma, collected from donors who have recovered from a pathogen of interest, has been used to treat infectious diseases, particularly in times of outbreak, when alternative therapies were unavailable. The COVID-19 pandemic revived interest in the use of convalescent plasma. Large observational studies and clinical trials that were executed during the pandemic provided insight into how to use convalescent plasma, whereby high levels of antibodies against the pathogen of interest and administration early within the time course of the disease are critical for optimal therapeutic effect. Several studies have shown outpatient administration of COVID-19 convalescent plasma (CCP) to be both safe and effective, preventing clinical progression in patients when administered within the first week of COVID-19. The United States Food and Drug Administration expanded its emergency use authorization (EUA) to allow for the administration of CCP in an outpatient setting in December 2021, at least for immunocompromised patients or those on immunosuppressive therapy. Outpatient transfusion of CCP and infusion of monoclonal antibody therapies for a highly transmissible infectious disease introduces nuanced challenges related to infection prevention. Drawing on our experiences with the clinical and research use of CCP, we describe the logistical considerations and workflow spanning procurement of qualified products, infrastructure, staffing, transfusion, and associated management of adverse events. The purpose of this description is to facilitate the efforts of others intent on establishing outpatient transfusion programs for CCP and other antibody-based therapies.
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- 2022
9. Association Between Hematoma Volume and Risk of Subsequent Ischemic Stroke: A MISTIE III and ATACH-2 Analysis
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Harris, William, Kaiser, Jed H., Liao, Vanessa, Avadhani, Radhika, Iadecola, Costantino, Falcone, Guido J., Sheth, Kevin N., Qureshi, Adnan I., Goldstein, Joshua N., Awad, Issam A., Hanley, Daniel F., Kamel, Hooman, Ziai, Wendy C., and Murthy, Santosh B.
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- 2024
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10. Baseline Characteristics of Patients With Cavernous Angiomas With Symptomatic Hemorrhage in Multisite Trial Readiness Project
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Kim, Helen, Flemming, Kelly D, Nelson, Jeffrey A, Lui, Avery, Majersik, Jennifer J, Dela Cruz, Michael, Zabramski, Joseph, Trevizo, Odilette, Lanzino, Giuseppe, Zafar, Atif, Torbey, Michel, Mabray, Marc C, Robinson, Myranda, Narvid, Jared, Lupo, Janine, Thompson, Richard E, Hanley, Daniel F, McBee, Nichol, Treine, Kevin, Ostapkovich, Noeleen, Stadnik, Agnieszka, Piedad, Kristina, Hobson, Nicholas, Carroll, Timothy, Shkoukani, Abdallah, Carrión-Penagos, Julián, Mendoza-Puccini, Carolina, Koenig, James I, and Awad, Issam
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Biomedical and Clinical Sciences ,Clinical Sciences ,Clinical Research ,Clinical Trials and Supportive Activities ,Neurosciences ,Stroke ,Brain Disorders ,Good Health and Well Being ,Adult ,Aged ,Brain Neoplasms ,Cerebral Hemorrhage ,Cohort Studies ,Female ,Hemangioma ,Cavernous ,Central Nervous System ,Humans ,Magnetic Resonance Imaging ,Male ,Middle Aged ,Neuroimaging ,biomarkers ,clinical trial ,intracranial hemorrhage ,magnetic resonance imaging ,quality of life ,vascular malformations ,Cardiorespiratory Medicine and Haematology ,Neurology & Neurosurgery ,Clinical sciences ,Allied health and rehabilitation science - Abstract
Background and purposeBrain cavernous angiomas with symptomatic hemorrhage (CASH) have a high risk of neurological disability from recurrent bleeding. Systematic assessment of baseline features and multisite validation of novel magnetic resonance imaging biomarkers are needed to optimize clinical trial design aimed at novel pharmacotherapies in CASH.MethodsThis prospective, multicenter, observational cohort study included adults with unresected, adjudicated brain CASH within the prior year. Six US sites screened and enrolled patients starting August 2018. Baseline demographics, clinical and imaging features, functional status (modified Rankin Scale and National Institutes of Health Stroke Scale), and patient quality of life outcomes (Patient-Reported Outcomes Measurement Information System-29 and EuroQol-5D) were summarized using descriptive statistics. Patient-Reported Outcomes Measurement Information System-29 scores were standardized against a reference population (mean 50, SD 10), and one-sample t test was performed for each domain. A subgroup underwent harmonized magnetic resonance imaging assessment of lesional iron content with quantitative susceptibility mapping and vascular permeability with dynamic contrast-enhanced quantitative perfusion.ResultsAs of May 2020, 849 patients were screened and 110 CASH cases enrolled (13% prevalence of trial eligible cases). The average age at consent was 46±16 years, 53% were female, 41% were familial, and 43% were brainstem lesions. At enrollment, ≥90% of the cohort had independent functional outcome (modified Rankin Scale score ≤2 and National Institutes of Health Stroke Scale score 30% of patients (EuroQol-5D). Patients had significantly worse Patient-Reported Outcomes Measurement Information System-29 scores for anxiety (P=0.007), but better depression (P=0.002) and social satisfaction scores (P=0.012) compared with the general reference population. Mean baseline quantitative susceptibility mapping and permeability of CASH lesion were 0.45±0.17 ppm and 0.39±0.31 mL/100 g per minute, respectively, which were similar to historical CASH cases and consistent across sites.ConclusionsThese baseline features will aid investigators in patient stratification and determining the most appropriate outcome measures for clinical trials of emerging pharmacotherapies in CASH.
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- 2021
11. Proceedings of the First Curing Coma Campaign NIH Symposium: Challenging the Future of Research for Coma and Disorders of Consciousness.
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Claassen, Jan, Akbari, Yama, Alexander, Sheila, Bader, Mary Kay, Bell, Kathleen, Bleck, Thomas P, Boly, Melanie, Brown, Jeremy, Chou, Sherry H-Y, Diringer, Michael N, Edlow, Brian L, Foreman, Brandon, Giacino, Joseph T, Gosseries, Olivia, Green, Theresa, Greer, David M, Hanley, Daniel F, Hartings, Jed A, Helbok, Raimund, Hemphill, J Claude, Hinson, HE, Hirsch, Karen, Human, Theresa, James, Michael L, Ko, Nerissa, Kondziella, Daniel, Livesay, Sarah, Madden, Lori K, Mainali, Shraddha, Mayer, Stephan A, McCredie, Victoria, McNett, Molly M, Meyfroidt, Geert, Monti, Martin M, Muehlschlegel, Susanne, Murthy, Santosh, Nyquist, Paul, Olson, DaiWai M, Provencio, J Javier, Rosenthal, Eric, Sampaio Silva, Gisele, Sarasso, Simone, Schiff, Nicholas D, Sharshar, Tarek, Shutter, Lori, Stevens, Robert D, Vespa, Paul, Videtta, Walter, Wagner, Amy, Ziai, Wendy, Whyte, John, Zink, Elizabeth, Suarez, Jose I, and Curing Coma Campaign
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Curing Coma Campaign ,Biomarkers ,Coma ,Consciousness ,Electrophysiology ,Magnetic resonance imaging ,Clinical Sciences ,Neurosciences ,Neurology & Neurosurgery - Abstract
Coma and disorders of consciousness (DoC) are highly prevalent and constitute a burden for patients, families, and society worldwide. As part of the Curing Coma Campaign, the Neurocritical Care Society partnered with the National Institutes of Health to organize a symposium bringing together experts from all over the world to develop research targets for DoC. The conference was structured along six domains: (1) defining endotype/phenotypes, (2) biomarkers, (3) proof-of-concept clinical trials, (4) neuroprognostication, (5) long-term recovery, and (6) large datasets. This proceedings paper presents actionable research targets based on the presentations and discussions that occurred at the conference. We summarize the background, main research gaps, overall goals, the panel discussion of the approach, limitations and challenges, and deliverables that were identified.
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- 2021
12. Trial Readiness of Cavernous Malformations With Symptomatic Hemorrhage, Part II: Biomarkers and Trial Modeling
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Hage, Stephanie, Kinkade, Serena, Girard, Romuald, Flemming, Kelly D., Kim, Helen, Torbey, Michel T., Huang, Judy, Huston, John, III, Shu, Yunhong, Selwyn, Reed G., Hart, Blaine L., Mabray, Marc C., Feghali, James, Sair, Haris I., Narvid, Jared, Lupo, Janine M., Lee, Justine, Stadnik, Agnieszka, Alcazar-Felix, Roberto J., Shenkar, Robert, Hobson, Nicholas, DeBiasse, Dorothy, Lane, Karen, McBee, Nichole A., Treine, Kevin, Ostapkovich, Noeleen, Wang, Ying, Thompson, Richard E., Koenig, James I., Carroll, Timothy, Hanley, Daniel F., Jr, and Awad, Issam A.
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- 2024
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13. New Mechanistic Insights, Novel Treatment Paradigms, and Clinical Progress in Cerebrovascular Diseases.
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Boltze, Johannes, Aronowski, Jaroslaw A, Badaut, Jerome, Buckwalter, Marion S, Caleo, Mateo, Chopp, Michael, Dave, Kunjan R, Didwischus, Nadine, Dijkhuizen, Rick M, Doeppner, Thorsten R, Dreier, Jens P, Fouad, Karim, Gelderblom, Mathias, Gertz, Karen, Golubczyk, Dominika, Gregson, Barbara A, Hamel, Edith, Hanley, Daniel F, Härtig, Wolfgang, Hummel, Friedhelm C, Ikhsan, Maulana, Janowski, Miroslaw, Jolkkonen, Jukka, Karuppagounder, Saravanan S, Keep, Richard F, Koerte, Inga K, Kokaia, Zaal, Li, Peiying, Liu, Fudong, Lizasoain, Ignacio, Ludewig, Peter, Metz, Gerlinde AS, Montagne, Axel, Obenaus, Andre, Palumbo, Alex, Pearl, Monica, Perez-Pinzon, Miguel, Planas, Anna M, Plesnila, Nikolaus, Raval, Ami P, Rueger, Maria A, Sansing, Lauren H, Sohrabji, Farida, Stagg, Charlotte J, Stetler, R Anne, Stowe, Ann M, Sun, Dandan, Taguchi, Akihiko, Tanter, Mickael, Vay, Sabine U, Vemuganti, Raghu, Vivien, Denis, Walczak, Piotr, Wang, Jian, Xiong, Ye, and Zille, Marietta
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cell therapies ,dementia ,experimental therapy ,hemorrhage ,neuroprotection ,neurorehabilitation ,stroke ,translational research ,Biochemistry and Cell Biology ,Neurosciences ,Cognitive Sciences - Abstract
The past decade has brought tremendous progress in diagnostic and therapeutic options for cerebrovascular diseases as exemplified by the advent of thrombectomy in ischemic stroke, benefitting a steeply increasing number of stroke patients and potentially paving the way for a renaissance of neuroprotectants. Progress in basic science has been equally impressive. Based on a deeper understanding of pathomechanisms underlying cerebrovascular diseases, new therapeutic targets have been identified and novel treatment strategies such as pre- and post-conditioning methods were developed. Moreover, translationally relevant aspects are increasingly recognized in basic science studies, which is believed to increase their predictive value and the relevance of obtained findings for clinical application.This review reports key results from some of the most remarkable and encouraging achievements in neurovascular research that have been reported at the 10th International Symposium on Neuroprotection and Neurorepair. Basic science topics discussed herein focus on aspects such as neuroinflammation, extracellular vesicles, and the role of sex and age on stroke recovery. Translational reports highlighted endovascular techniques and targeted delivery methods, neurorehabilitation, advanced functional testing approaches for experimental studies, pre-and post-conditioning approaches as well as novel imaging and treatment strategies. Beyond ischemic stroke, particular emphasis was given on activities in the fields of traumatic brain injury and cerebral hemorrhage in which promising preclinical and clinical results have been reported. Although the number of neutral outcomes in clinical trials is still remarkably high when targeting cerebrovascular diseases, we begin to evidence stepwise but continuous progress towards novel treatment options. Advances in preclinical and translational research as reported herein are believed to have formed a solid foundation for this progress.
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- 2021
14. tPA-NMDAR Signaling Blockade Reduces the Incidence of Intracerebral Aneurysms
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Louet, Estelle R., Glavan, Martina, Orset, Cyrille, Parcq, Jerome, Hanley, Daniel F., and Vivien, Denis
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- 2022
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15. Who Determines the Quality of Life of Survivors of Severe Traumatic Brain Injury?
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Carhuapoma, Lourdes R., Avadhani, Radhika, and Hanley, Daniel F.
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- 2023
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16. Intra-arterial thrombolysis as adjunct to mechanical thrombectomy in acute ischemic stroke patients in the United States: A case control analysis
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Kwok, Chun Shing, Bains, Navpreet K., Ford, Daniel E., Gomez, Camilo R., Hanley, Daniel F., Hassan, Ameer E., Nguyen, Thanh N., Siddiq, Farhan, Spiotta, Alejandro M., Zaidi, Syed F., and Qureshi, Adnan I.
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- 2023
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17. The Curing Coma Campaign: Framing Initial Scientific Challenges—Proceedings of the First Curing Coma Campaign Scientific Advisory Council Meeting
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Provencio, J Javier, Hemphill, J Claude, Claassen, Jan, Edlow, Brian L, Helbok, Raimund, Vespa, Paul M, Diringer, Michael N, Polizzotto, Len, Shutter, Lori, Suarez, Jose I, Stevens, Robert D, Hanley, Daniel F, Akbari, Yama, Bleck, Thomas P, Boly, Melanie, Foreman, Brandon, Giacino, Joseph T, Hartings, Jed A, Human, Theresa, Kondziella, Daniel, Ling, Geoffrey SF, Mayer, Stephan A, McNett, Molly, Menon, David K, Meyfroidt, Geert, Monti, Martin M, Park, Soojin, Pouratian, Nader, Puybasset, Louis, Rohaut, Benjamin, Rosenthal, Eric S, Schiff, Nicholas D, Sharshar, Tarek, Wagner, Amy, Whyte, John, and Olson, DaiWai M
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Health Services and Systems ,Biomedical and Clinical Sciences ,Health Sciences ,Brain Disorders ,Good Health and Well Being ,Advisory Committees ,Biomarkers ,Clinical Trials as Topic ,Coma ,Consciousness Disorders ,Critical Care ,Humans ,Implementation Science ,Neurological Rehabilitation ,Neurology ,Proof of Concept Study ,Stakeholder Participation ,Endotype ,Biomarker ,Consciousness ,Recovery ,Neurocritical Care Society Curing Coma Campaign ,Clinical Sciences ,Neurosciences ,Neurology & Neurosurgery ,Clinical sciences ,Nursing - Abstract
Coma and disordered consciousness are common manifestations of acute neurological conditions and are among the most pervasive and challenging aspects of treatment in neurocritical care. Gaps exist in patient assessment, outcome prognostication, and treatment directed specifically at improving consciousness and cognitive recovery. In 2019, the Neurocritical Care Society (NCS) launched the Curing Coma Campaign in order to address the "grand challenge" of improving the management of patients with coma and decreased consciousness. One of the first steps was to bring together a Scientific Advisory Council including coma scientists, neurointensivists, neurorehabilitationists, and implementation experts in order to address the current scientific landscape and begin to develop a framework on how to move forward. This manuscript describes the proceedings of the first Curing Coma Campaign Scientific Advisory Council meeting which occurred in conjunction with the NCS Annual Meeting in October 2019 in Vancouver. Specifically, three major pillars were identified which should be considered: endotyping of coma and disorders of consciousness, biomarkers, and proof-of-concept clinical trials. Each is summarized with regard to current approach, benefits to the patient, family, and clinicians, and next steps. Integration of these three pillars will be essential to the success of the Curing Coma Campaign as will expanding the "curing coma community" to ensure broad participation of clinicians, scientists, and patient advocates with the goal of identifying and implementing treatments to fundamentally improve the outcome of patients.
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- 2020
18. Mechanisms to expedite pediatric clinical trial site activation: The DOSE trial experience
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Boutzoukas, Angelique E., Olson, Rachel, Sellers, Mary Ann, Fischer, Gwenyth, Hornik, Chi D., Alibrahim, Omar, Iheagwara, Kelechi, Abulebda, Kamal, Bass, Andora L., Irby, Katherine, Subbaswamy, Anjali, Zivick, Elizabeth E., Sweney, Jill, Stormorken, Anne G., Barker, Erin E., Lutfi, Riad, McCrory, Michael C., Costello, John M., Ackerman, Kate G., Munoz Pareja, Jennifer C., Dean, J. Michael, Abdelsamad, Nael, Hanley, Daniel F., Jr, Mould, W. Andrew, Lane, Karen, Stroud, Mary, Feger, Bryan J., Greenberg, Rachel G., Smith, P. Brian, Benjamin, Daniel K., Jr, Hornik, Christoph P., Zimmerman, Kanecia O., and Becker, Mara L.
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- 2023
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19. Early Hyperchloremia is Independently Associated with Death or Disability in Patients with Intracerebral Hemorrhage
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Qureshi, Adnan I., Huang, Wei, Hanley, Daniel F., Hsu, Chung Y., Martin, Renee H., Malhotra, Kunal, Steiner, Thorsten, Suarez, Jose I., Yamamoto, Haruko, and Toyoda, Kazunori
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- 2022
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20. Convalescent plasma with a high level of virus-specific antibody effectively neutralizes SARS-CoV-2 variants of concern
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Li, Maggie, Beck, Evan J., Laeyendecker, Oliver, Eby, Yolanda, Tobian, Aaron A.R., Caturegli, Patrizio, Wouters, Camille, Chiklis, Gregory R., Block, William, McKie, Robert O., Joyner, Michael J., Wiltshire, Timothy D., Dietz, Allan B., Gniadek, Thomas J., Shapiro, Arell J., Yarava, Anusha, Lane, Karen, Hanley, Daniel F., Bloch, Evan M., Shoham, Shmuel, Cachay, Edward R., Meisenberg, Barry R., Huaman, Moises A., Fukuta, Yuriko, Patel, Bela, Heath, Sonya L., Levine, Adam C., Paxton, James H., Anjan, Shweta, Gerber, Jonathan M., Gebo, Kelly A., Casadevall, Arturo, Pekosz, Andrew, and Sullivan, David J.
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- 2022
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21. Estimates of actual and potential lives saved in the United States from the use of COVID-19 convalescent plasma.
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Dragotakes, Quigly, Johnson, Patrick W., Buras, Matthew R., Carter, Rickey E., Joyner, Michael J., Bloch, Evan, Gebo, Kelly A., Hanley, Daniel F., Henderson, Jeffrey P., Pirofski, Liise-Anne, Shoham, Shmuel, Senefeld, Jonathon W., Tobian, Aaron A. R., Wiggins, Chad C., Wright, R. Scott, Paneth, Nigel S., Sullivan, David J., and Casadevall, Arturo
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CONVALESCENT plasma ,COVID-19 pandemic ,RANDOMIZED controlled trials ,COMMUNICABLE diseases ,HOSPITAL patients - Abstract
In the Spring of 2020, the United States of America (USA) deployed COVID-19 convalescent plasma (CCP) to treat hospitalized patients. Over 500,000 patients were treated with CCP during the first year of the pandemic. In this study, we estimated the number of actual inpatient lives saved by CCP treatment in the United States of America based on CCP weekly use, weekly national mortality data, and CCP mortality reduction data from meta-analyses of randomized controlled trials and real-world data. We also estimate the potential number of lives saved if CCP had been deployed for 100% of hospitalized patients or used in 15 to 75% of outpatients. Depending on the assumptions modeled in stratified analyses, we estimated that CCP saved between 16,476 and 66,296 lives. The CCP ideal use might have saved as many as 234,869 lives and prevented 1,136,133 hospitalizations. CCP deployment was a successful strategy for ameliorating the impact of the COVID-19 pandemic in the USA. This experience has important implications for convalescent plasma use in future infectious disease emergencies. [ABSTRACT FROM AUTHOR]
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- 2024
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22. Hemorrhage Expansion Rates Before and After Minimally Invasive Surgery for Intracerebral Hemorrhage: Post Hoc Analysis of MISTIE II/III
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Ziai, Wendy C., primary, Badihian, Shervin, additional, Ullman, Natalie, additional, Thompson, Carol B., additional, Hildreth, Meghan, additional, Piran, Pirouz, additional, Montano, Nataly, additional, Vespa, Paul, additional, Martin, Neil, additional, Zuccarello, Mario, additional, Mayo, Steven W., additional, Awad, Issam, additional, and Hanley, Daniel F., additional
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- 2024
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23. Outpatient COVID-19 convalescent plasma recipient antibody thresholds correlated to reduced hospitalizations within a randomized trial
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Park, Han-Sol, primary, Yin, Anna, additional, Barranta, Caelan, additional, Lee, John S., additional, Caputo, Christopher A., additional, Sachithanandham, Jaiprasath, additional, Li, Maggie, additional, Yoon, Steve, additional, Sitaras, Ioannis, additional, Jedlicka, Anne, additional, Eby, Yolanda, additional, Ram, Malathi, additional, Fernandez, Reinaldo E., additional, Baker, Owen R., additional, Shenoy, Aarthi G., additional, Mosnaim, Giselle S., additional, Fukuta, Yuriko, additional, Patel, Bela, additional, Heath, Sonya L., additional, Levine, Adam C., additional, Meisenberg, Barry R., additional, Spivak, Emily S., additional, Anjan, Shweta, additional, Huaman, Moises A., additional, Blair, Janis E., additional, Currier, Judith S., additional, Paxton, James H., additional, Gerber, Jonathan M., additional, Petrini, Joann R., additional, Broderick, Patrick B., additional, Rausch, William, additional, Cordisco, Marie Elena, additional, Hammel, Jean, additional, Greenblatt, Benjamin, additional, Cluzet, Valerie C., additional, Cruser, Daniel, additional, Oei, Kevin, additional, Abinante, Matthew, additional, Hammitt, Laura L., additional, Sutcliffe, Catherine G., additional, Forthal, Donald N., additional, Zand, Martin S., additional, Cachay, Edward R., additional, Raval, Jay S., additional, Kassaye, Seble G., additional, Marshall, Christi E., additional, Yarava, Anusha, additional, Lane, Karen, additional, McBee, Nichol A., additional, Gawad, Amy L., additional, Karlen, Nicky, additional, Singh, Atika, additional, Ford, Daniel E., additional, Jabs, Douglas A., additional, Appel, Lawrence J., additional, Shade, David M., additional, Lau, Bryan, additional, Ehrhardt, Stephan, additional, Baksh, Sheriza N., additional, Shapiro, Janna R., additional, Ou, Jiangda, additional, Na, Yu Bin, additional, Knoll, Maria D., additional, Ornelas-Gatdula, Elysse, additional, Arroyo-Curras, Netzahualcoyotl, additional, Gniadek, Thomas J., additional, Caturegli, Patrizio, additional, Wu, Jinke, additional, Ndahiro, Nelson, additional, Betenbaugh, Michael J., additional, Ziman, Alyssa, additional, Hanley, Daniel F., additional, Casadevall, Arturo, additional, Shoham, Shmuel, additional, Bloch, Evan M., additional, Gebo, Kelly A., additional, Tobian, Aaron A.R., additional, Laeyendecker, Oliver, additional, Pekosz, Andrew, additional, Klein, Sabra L., additional, and Sullivan, David J., additional
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- 2024
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24. Corrigendum: Ultrastructural characteristics of neuronal death and white matter injury in mouse brain tissues after intracerebral hemorrhage: coexistence of ferroptosis, autophagy, and necrosis
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Li, Qian, primary, Weiland, Abigail, additional, Chen, Xuemei, additional, Lan, Xi, additional, Han, Xiaoning, additional, Durham, Frederick, additional, Liu, Xi, additional, Wan, Jieru, additional, Ziai, Wendy C., additional, Hanley, Daniel F., additional, and Wang, Jian, additional
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- 2024
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25. Abstract 141: Physician Transfer versus Patient Transfer for Mechanical Thrombectomy in Patients With Acute Ischemic Stroke: A Systematic Review and Meta-Analysis
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Suri, M. Fareed K, primary, Lodhi, Abdullah, additional, Maqsood, Hamza, additional, Ma, Xiaoyu, additional, Hubert, Gordian J, additional, Gomez, Camilo R, additional, Kwok, Chun, additional, Ford, Daniel, additional, Hanley, Daniel F, additional, Mehr, David, additional, Shah, Qaisar, additional, and Qureshi, Adnan I, additional
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- 2024
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26. Abstract WMP79: Mobility Impairment is Not Associated With Long-Term Valuation of Health by Survivors of Intracerebral Hemorrhage: A Mediation Analysis
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Shah, Vishank A, primary, Carhuapoma, Lourdes, additional, Avadhani, Radhika, additional, Awad, Issam A, additional, Hanley, Daniel F, additional, and Ziai, Wendy C, additional
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- 2024
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27. Abstract TMP74: Association Between Hematoma Volume After Risk of Subsequent Ischemic Stroke: A MISTIE III and ATACH-2 Analysis
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Harris, William, primary, Kaiser, Jed, additional, Avadhani, Radhika, additional, Iadecola, Costantino, additional, Sheth, Kevin N, additional, Awad, Issam, additional, Goldstein, Joshua N, additional, Qureshi, Adnan I, additional, Hanley, Daniel F, additional, Kamel, Hooman, additional, Ziai, Wendy C, additional, and Murthy, Santosh B, additional
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- 2024
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28. Post-Stroke Depression in Patients with Large Spontaneous Intracerebral Hemorrhage
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Avadhani, Radhika, Thompson, Richard E., Carhuapoma, Lourdes, Yenokyan, Gayane, McBee, Nichol, Lane, Karen, Ostapkovich, Noeleen, Stadnik, Agnieszka, Awad, Issam A., Hanley, Daniel F., and Ziai, Wendy C.
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- 2021
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29. Post-Trial Enhanced Deployment and Technical Performance with the MISTIE Procedure per Lessons Learned
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Mansour, Ali, Loggini, Andrea, El Ammar, Faten, Alvarado-Dyer, Ronald, Polster, Sean, Stadnik, Agnieszka, Das, Paramita, Warnke, Peter C., Yamini, Bakhtiar, Lazaridis, Christos, Kramer, Christopher, Mould, W. Andrew, Hildreth, Meghan, Sharrock, Matthew, Hanley, Daniel F, Goldenberg, Fernando D., and Awad, Issam A.
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- 2021
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30. Improved Precision in the Analysis of Randomized Trials with Survival Outcomes, without Assuming Proportional Hazards
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Díaz, Iván, Colantuoni, Elizabeth, Hanley, Daniel F., and Rosenblum, Michael
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Mathematics - Statistics Theory ,Statistics - Methodology - Abstract
We present a new estimator of the restricted mean survival time in randomized trials where there is right censoring that may depend on treatment and baseline variables. The proposed estimator leverages prognostic baseline variables to obtain equal or better asymptotic precision compared to traditional estimators. Under regularity conditions and random censoring within strata of treatment and baseline variables, the proposed estimator has the following features: (i) it is interpretable under violations of the proportional hazards assumption; (ii) it is consistent and at least as precise as the Kaplan-Meier estimator under independent censoring; (iii) it remains consistent under violations of independent censoring (unlike the Kaplan-Meier estimator) when either the censoring or survival distributions are estimated consistently; and (iv) it achieves the nonparametric efficiency bound when both of these distributions are consistently estimated. We illustrate the performance of our method using simulations based on resampling data from a completed, phase 3 randomized clinical trial of a new surgical treatment for stroke; the proposed estimator achieves a 12% gain in relative efficiency compared to the Kaplan-Meier estimator. The proposed estimator has potential advantages over existing approaches for randomized trials with time-to-event outcomes, since existing methods either rely on model assumptions that are untenable in many applications, or lack some of the efficiency and consistency properties (i)-(iv). We focus on estimation of the restricted mean survival time, but our methods may be adapted to estimate any treatment effect measure defined as a smooth contrast between the survival curves for each study arm. We provide R code to implement the estimator.
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- 2015
31. Impact of Intracranial Pressure Monitor–Guided Therapy on Neurologic Outcome After Spontaneous Nontraumatic Intracranial Hemorrhage
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Menacho, Sarah T., Grandhi, Ramesh, Delic, Alen, Anadani, Mohammad, Ziai, Wendy C., Awad, Issam A., Hanley, Daniel F., and de Havenon, Adam
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- 2021
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32. 3D Deep Neural Network Segmentation of Intracerebral Hemorrhage: Development and Validation for Clinical Trials
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Sharrock, Matthew F., Mould, W. Andrew, Ali, Hasan, Hildreth, Meghan, Awad, Issam A., Hanley, Daniel F., and Muschelli, John
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- 2021
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33. Research considerations for prospective studies of patients with coma and disorders of consciousness
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Tinti, L, Lawson, T, Molteni, E, Kondziella, D, Rass, V, Sharshar, T, Bodien, Y, Giacino, J, Mayer, S, Amiri, M, Muehlschlegel, S, Venkatasubba Rao, C, Vespa, P, Menon, D, Citerio, G, Helbok, R, Mcnett, M, Agarwal, S, Aiyagari, V, Akbari, Y, Albertson, A, Alexander, S, Alexandrov, A, Alkhachroum, A, Al-Mufti, F, Appavu, B, Gebrewold, M, Ayounb, M, Badenes, R, Bader, M, Badjiata, N, Balu, R, Barlow, B, Barra, M, Beekman, R, Beghi, E, Beqiri, E, Berlin, T, Bilotta, F, Bleck, T, Boerwinkle, V, Boly, M, Bonnel, A, Brazzi, L, Brown, E, Bulic, S, Caceres, E, Caceres, A, Cafiero, T, Carroll, E, Cediel, E, Chou, S, Claassen, J, Condie, C, Conti, A, Cosmas, K, Costa, P, Creutzfeldt, C, Dangayach, N, Dauri, M, Debicki, D, Degeorgia, M, Der-Nigoghossian, C, Desai, M, Dhar, R, Diringer, M, Durr, E, Edlow, B, Ercole, A, Estraneo, A, Falcone, G, Farrokh, S, Ferguson, A, Fernandez-Espejo, D, Fink, E, Fins, J, Foreman, B, Franchi, F, Frontera, J, Ganesan, R, Gaspard, N, Ghavam, A, Gibbons, C, Gilmore, E, Glustein, C, Gosseries, O, Green, T, Greer, D, Guanci, M, Gupta, D, Hahn, C, Hakimi, R, Hammond, F, Hanley, D, Hartings, J, Hassan, A, Hemphill, C, Da Cunha, A, Hinson, H, Hirsch, K, Hocker, S, Hu, P, Hu, X, Human, T, Hwang, D, Illes, J, Jaffa, M, James, M, Janas, A, Johnson, S, Jones, M, Jox, R, Kalanuria, A, Keller, E, Kennedy, L, Kennelly, M, Keogh, M, Kim, J, Kim, K, Kirsch, H, Kirschen, M, Ko, N, Kreitzer, N, Kromm, J, Kumar, A, Kurtz, P, Laureys, S, Lejeune, N, Lewis, A, Liang, J, Ling, G, Livesay, S, Luppi, A, Macdonald, J, Maddux, C, Mahanes, D, Mainali, S, Maldonado, N, Ribeiro, R, Mascia, L, Massimini, M, Mathur, R, Mccredie, V, Mejia-Mantilla, J, Mendoza, M, Meyfroidt, G, Mijangos, J, Moberg, D, Moheet, A, Montalenti, E, Monti, M, Morrison, C, Munar, M, Murtaugh, B, Naccache, L, Nagayama, M, Nairon, E, Nakagawa, T, Naldi, A, Narenthiran, G, Natarajan, G, Nemetsky, E, Newcombe, V, Nielsen, N, Niznick, N, Noronha-Falcão, F, Nyquist, P, Olson, D, Othman, M, Owen, A, Padayachy, L, Pajoumand, M, Park, S, Pergakis, M, Perry, H, Polizzotto, L, Pouratian, N, Spivack, M, Prisco, L, Provencio, J, Puglises, F, Puybasset, L, Rao, C, Rasmussen, L, Rasulo, F, Ray, B, Ricci, Z, Richardson, R, Shinotsuka, C, Robba, C, Robertson, C, Rohaut, B, Rolston, J, Romagnoli, S, Rosanova, M, Rosenthal, E, Rowe, S, Rubin, M, Russell, M, Silva, G, Sanz, L, Sarasso, S, Sarwal, A, Schiff, N, Schnakers, C, Seder, D, Shah, V, Shapiro-Rosenbaubm, A, Shapshak, A, Sharma, K, Shutter, L, Sitt, J, Slomine, B, Smetana, K, Smielewski, P, Smith, W, Stamatakis, E, Steinberg, A, Stevens, R, Suarez, J, Sung, G, Sussman, B, Taran, S, Mazzeo, A, Thibaut, A, Thompson, D, Threlkeld, Z, Toker, D, Torbey, M, Tosto, J, Trevick, S, Tsaousi, G, Turgeon, A, Udy, A, Varelas, P, Videtta, W, Voss, H, Vox, F, Wagner, A, Wahlster, S, Wainwright, M, Whyte, J, Witherspoon, B, Yakhkind, A, Yeager, S, Young, M, Zafar, S, Zafonte, R, Zahuranec, D, Zammit, C, Zhang, B, Ziai, W, Zimmerman, L, Zink, E, Tinti, Lorenzo, Lawson, Thomas, Molteni, Erika, Kondziella, Daniel, Rass, Verena, Sharshar, Tarek, Bodien, Yelena G, Giacino, Joseph T, Mayer, Stephan A, Amiri, Moshgan, Muehlschlegel, Susanne, Venkatasubba Rao, Chethan P, Vespa, Paul M, Menon, David K, Citerio, Giuseppe, Helbok, Raimund, McNett, Molly, Agarwal, Sachin, Aiyagari, Venkatesh, Akbari, Yama, Albertson, Asher, Alexander, Sheila, Alexandrov, Anne, Alkhachroum, Ayham, Al-Mufti, Fawaz, Amiri, Moshagan, Appavu, Brian, Gebrewold, Meron Awraris, Ayounb, Marc, Badenes, Rafael, Bader, Mary Kay, Badjiata, Neeraj, Balu, Ram, Barlow, Brooke, Barra, Megan, Beekman, Rachel, Beghi, Ettore, Beqiri, Erta, Berlin, Tracey, Bilotta, Federico, Bleck, Thomas, Bodien, Yelena, Boerwinkle, Varina, Boly, Melanie, Bonnel, Alexandra, Brazzi, Luca, Brown, Emery, Bulic, Sebina, Caceres, Eder, Caceres, Adrian, Cafiero, Tullio, Carroll, Elizabeth, Cediel, Emilio G, Chou, Sherry, Claassen, Jan, Condie, Chad, Conti, Alfredo, Cosmas, Katie, Costa, Paolo, Creutzfeldt, Claire, Dangayach, Neha, Dauri, Mario, Debicki, Derek, DeGeorgia, Michael, Der-Nigoghossian, Caroline, Desai, Masoom, Dhar, Rajat, Diringer, Michael, Durr, Emily, Edlow, Brian, Ercole, Ari, Estraneo, Anna, Falcone, Guido, Farrokh, Salia, Ferguson, Adam, Fernandez-Espejo, Davinia, Fink, Ericka, Fins, Joseph, Foreman, Brandon, Franchi, Federico, Frontera, Jennifer, Ganesan, Rishi, Gaspard, Nicolas, Ghavam, Ahmeneh, Giacino, Joseph, Gibbons, Christie, Gilmore, Emily, Glustein, Chavie, Gosseries, Olivia, Green, Theresa, Greer, David, Guanci, Mary, Gupta, Deepak, Hahn, Cecil, Hakimi, Ryan, Hammond, Flora, Hanley, Daniel F, Hartings, Jed, Hassan, Ahmed, Hemphill, Claude, Da Cunha, Arthur Henrique Galvão Bruno, Hinson, Holly, Hirsch, Karen, Hocker, Sarah, Hu, Peter, Hu, Xiao, Human, Theresa, Hwang, David, Illes, Judy, Jaffa, Matthew, James, Michael L, Janas, Anna, Johnson, Susan, Jones, Morgan, Jox, Ralf J, Kalanuria, Atul, Keller, Emanuela, Kennedy, Lori, Kennelly, Megan, Keogh, Maggie, Kim, Jenn, Kim, Keri, Kirsch, Hannah, Kirschen, Matthew, Ko, Nerissa, Kreitzer, Natalie, Kromm, Julie, Kumar, Abhay, Kurtz, Pedro, Laureys, Steven, Lejeune, Nicolas, Lewis, Ariane, Liang, John, Ling, Geoffrey, Livesay, Sarah, Luppi, Andrea, MacDonald, Jennifer, Maddux, Craig, Mahanes, Dea, Mainali, Shraddha, Maldonado, Nelson, Ribeiro, Rennan Martins, Mascia, Luciana, Massimini, Marcello, Mathur, Rohan, Mayer, Stephan, McCredie, Victoria, Mejia-Mantilla, Jorge, Mendoza, Michael, Menon, David, Meyfroidt, Geert, Mijangos, Julio, Moberg, Dick, Moheet, Asma, Montalenti, Elisa, Monti, Martin, Morrison, Chris, Munar, Marina, Murtaugh, Brooke, Naccache, Lionel, Nagayama, Masao, Nairon, Emerson, Nakagawa, Thomas, Naldi, Andrea, Narenthiran, Ganesalingam, Natarajan, Girija, Nemetsky, Esther, Newcombe, Virginia, Nielsen, Niklas, Niznick, Naomi, Noronha-Falcão, Filipa, Nyquist, Paul, Olson, DaiWai, Othman, Marwan, Owen, Adrian, Padayachy, Llewellyn, Pajoumand, Mehrnaz, Park, Soojin, Pergakis, Melissa, Perry, Heidi, Polizzotto, Len, Pouratian, Nader, Spivack, Marilyn Price, Prisco, Lara, Provencio, Javier, Puglises, Francesco, Puybasset, Louis, Rao, Chethan, Rasmussen, Lindsay, Rasulo, Frank, Ray, Bappaditya, Ricci, Zaccaria, Richardson, Risa, Shinotsuka, Cassia Righy, Robba, Chiara, Robertson, Courtney, Rohaut, Benjamin, Rolston, John, Romagnoli, Stefano, Rosanova, Mario, Rosenthal, Eric, Rowe, Shaun, Rubin, Michael, Russell, Mary Beth, Silva, Gisele Sampaio, Sanz, Leandro, Sarasso, Simone, Sarwal, Aarti, Schiff, Nicolas, Schnakers, Caroline, Seder, David, Shah, Vishank Arun, Shapiro-Rosenbaubm, Amy, Shapshak, Angela, Sharma, Kartavya, Sharma, Kumar Ajay, Shutter, Lori, Sitt, Jacobo, Slomine, Beth, Smetana, Keaton, Smielewski, Peter, Smith, Wade, Stamatakis, Emmanuel, Steinberg, Alexis, Stevens, Robert, Suarez, Jose, Sung, Gene, Sussman, Bethany, Taran, Shaurya, Mazzeo, Anna Teresa, Thibaut, Aurore, Thompson, David, Threlkeld, Zachary, Toker, Daniel, Torbey, Michel, Tosto, Jenna, Trevick, Stephen, Tsaousi, Georgia, Turgeon, Alexis, Udy, Andrew, Varelas, Panos, Vespa, Paul, Videtta, Walter, Voss, Henning, Vox, Ford, Wagner, Amy, Wahlster, Sarah, Wainwright, Mark, Whyte, John, Witherspoon, Briana, Yakhkind, Aleksandra (Sasha), Yeager, Susan, Young, Michael, Zafar, Sahar, Zafonte, Ross, Zahuranec, Darin, Zammit, Chris, Zhang, Bei, Ziai, Wendy, Zimmerman, Lara, Zink, Elizabeth, Tinti, L, Lawson, T, Molteni, E, Kondziella, D, Rass, V, Sharshar, T, Bodien, Y, Giacino, J, Mayer, S, Amiri, M, Muehlschlegel, S, Venkatasubba Rao, C, Vespa, P, Menon, D, Citerio, G, Helbok, R, Mcnett, M, Agarwal, S, Aiyagari, V, Akbari, Y, Albertson, A, Alexander, S, Alexandrov, A, Alkhachroum, A, Al-Mufti, F, Appavu, B, Gebrewold, M, Ayounb, M, Badenes, R, Bader, M, Badjiata, N, Balu, R, Barlow, B, Barra, M, Beekman, R, Beghi, E, Beqiri, E, Berlin, T, Bilotta, F, Bleck, T, Boerwinkle, V, Boly, M, Bonnel, A, Brazzi, L, Brown, E, Bulic, S, Caceres, E, Caceres, A, Cafiero, T, Carroll, E, Cediel, E, Chou, S, Claassen, J, Condie, C, Conti, A, Cosmas, K, Costa, P, Creutzfeldt, C, Dangayach, N, Dauri, M, Debicki, D, Degeorgia, M, Der-Nigoghossian, C, Desai, M, Dhar, R, Diringer, M, Durr, E, Edlow, B, Ercole, A, Estraneo, A, Falcone, G, Farrokh, S, Ferguson, A, Fernandez-Espejo, D, Fink, E, Fins, J, Foreman, B, Franchi, F, Frontera, J, Ganesan, R, Gaspard, N, Ghavam, A, Gibbons, C, Gilmore, E, Glustein, C, Gosseries, O, Green, T, Greer, D, Guanci, M, Gupta, D, Hahn, C, Hakimi, R, Hammond, F, Hanley, D, Hartings, J, Hassan, A, Hemphill, C, Da Cunha, A, Hinson, H, Hirsch, K, Hocker, S, Hu, P, Hu, X, Human, T, Hwang, D, Illes, J, Jaffa, M, James, M, Janas, A, Johnson, S, Jones, M, Jox, R, Kalanuria, A, Keller, E, Kennedy, L, Kennelly, M, Keogh, M, Kim, J, Kim, K, Kirsch, H, Kirschen, M, Ko, N, Kreitzer, N, Kromm, J, Kumar, A, Kurtz, P, Laureys, S, Lejeune, N, Lewis, A, Liang, J, Ling, G, Livesay, S, Luppi, A, Macdonald, J, Maddux, C, Mahanes, D, Mainali, S, Maldonado, N, Ribeiro, R, Mascia, L, Massimini, M, Mathur, R, Mccredie, V, Mejia-Mantilla, J, Mendoza, M, Meyfroidt, G, Mijangos, J, Moberg, D, Moheet, A, Montalenti, E, Monti, M, Morrison, C, Munar, M, Murtaugh, B, Naccache, L, Nagayama, M, Nairon, E, Nakagawa, T, Naldi, A, Narenthiran, G, Natarajan, G, Nemetsky, E, Newcombe, V, Nielsen, N, Niznick, N, Noronha-Falcão, F, Nyquist, P, Olson, D, Othman, M, Owen, A, Padayachy, L, Pajoumand, M, Park, S, Pergakis, M, Perry, H, Polizzotto, L, Pouratian, N, Spivack, M, Prisco, L, Provencio, J, Puglises, F, Puybasset, L, Rao, C, Rasmussen, L, Rasulo, F, Ray, B, Ricci, Z, Richardson, R, Shinotsuka, C, Robba, C, Robertson, C, Rohaut, B, Rolston, J, Romagnoli, S, Rosanova, M, Rosenthal, E, Rowe, S, Rubin, M, Russell, M, Silva, G, Sanz, L, Sarasso, S, Sarwal, A, Schiff, N, Schnakers, C, Seder, D, Shah, V, Shapiro-Rosenbaubm, A, Shapshak, A, Sharma, K, Shutter, L, Sitt, J, Slomine, B, Smetana, K, Smielewski, P, Smith, W, Stamatakis, E, Steinberg, A, Stevens, R, Suarez, J, Sung, G, Sussman, B, Taran, S, Mazzeo, A, Thibaut, A, Thompson, D, Threlkeld, Z, Toker, D, Torbey, M, Tosto, J, Trevick, S, Tsaousi, G, Turgeon, A, Udy, A, Varelas, P, Videtta, W, Voss, H, Vox, F, Wagner, A, Wahlster, S, Wainwright, M, Whyte, J, Witherspoon, B, Yakhkind, A, Yeager, S, Young, M, Zafar, S, Zafonte, R, Zahuranec, D, Zammit, C, Zhang, B, Ziai, W, Zimmerman, L, Zink, E, Tinti, Lorenzo, Lawson, Thomas, Molteni, Erika, Kondziella, Daniel, Rass, Verena, Sharshar, Tarek, Bodien, Yelena G, Giacino, Joseph T, Mayer, Stephan A, Amiri, Moshgan, Muehlschlegel, Susanne, Venkatasubba Rao, Chethan P, Vespa, Paul M, Menon, David K, Citerio, Giuseppe, Helbok, Raimund, McNett, Molly, Agarwal, Sachin, Aiyagari, Venkatesh, Akbari, Yama, Albertson, Asher, Alexander, Sheila, Alexandrov, Anne, Alkhachroum, Ayham, Al-Mufti, Fawaz, Amiri, Moshagan, Appavu, Brian, Gebrewold, Meron Awraris, Ayounb, Marc, Badenes, Rafael, Bader, Mary Kay, Badjiata, Neeraj, Balu, Ram, Barlow, Brooke, Barra, Megan, Beekman, Rachel, Beghi, Ettore, Beqiri, Erta, Berlin, Tracey, Bilotta, Federico, Bleck, Thomas, Bodien, Yelena, Boerwinkle, Varina, Boly, Melanie, Bonnel, Alexandra, Brazzi, Luca, Brown, Emery, Bulic, Sebina, Caceres, Eder, Caceres, Adrian, Cafiero, Tullio, Carroll, Elizabeth, Cediel, Emilio G, Chou, Sherry, Claassen, Jan, Condie, Chad, Conti, Alfredo, Cosmas, Katie, Costa, Paolo, Creutzfeldt, Claire, Dangayach, Neha, Dauri, Mario, Debicki, Derek, DeGeorgia, Michael, Der-Nigoghossian, Caroline, Desai, Masoom, Dhar, Rajat, Diringer, Michael, Durr, Emily, Edlow, Brian, Ercole, Ari, Estraneo, Anna, Falcone, Guido, Farrokh, Salia, Ferguson, Adam, Fernandez-Espejo, Davinia, Fink, Ericka, Fins, Joseph, Foreman, Brandon, Franchi, Federico, Frontera, Jennifer, Ganesan, Rishi, Gaspard, Nicolas, Ghavam, Ahmeneh, Giacino, Joseph, Gibbons, Christie, Gilmore, Emily, Glustein, Chavie, Gosseries, Olivia, Green, Theresa, Greer, David, Guanci, Mary, Gupta, Deepak, Hahn, Cecil, Hakimi, Ryan, Hammond, Flora, Hanley, Daniel F, Hartings, Jed, Hassan, Ahmed, Hemphill, Claude, Da Cunha, Arthur Henrique Galvão Bruno, Hinson, Holly, Hirsch, Karen, Hocker, Sarah, Hu, Peter, Hu, Xiao, Human, Theresa, Hwang, David, Illes, Judy, Jaffa, Matthew, James, Michael L, Janas, Anna, Johnson, Susan, Jones, Morgan, Jox, Ralf J, Kalanuria, Atul, Keller, Emanuela, Kennedy, Lori, Kennelly, Megan, Keogh, Maggie, Kim, Jenn, Kim, Keri, Kirsch, Hannah, Kirschen, Matthew, Ko, Nerissa, Kreitzer, Natalie, Kromm, Julie, Kumar, Abhay, Kurtz, Pedro, Laureys, Steven, Lejeune, Nicolas, Lewis, Ariane, Liang, John, Ling, Geoffrey, Livesay, Sarah, Luppi, Andrea, MacDonald, Jennifer, Maddux, Craig, Mahanes, Dea, Mainali, Shraddha, Maldonado, Nelson, Ribeiro, Rennan Martins, Mascia, Luciana, Massimini, Marcello, Mathur, Rohan, Mayer, Stephan, McCredie, Victoria, Mejia-Mantilla, Jorge, Mendoza, Michael, Menon, David, Meyfroidt, Geert, Mijangos, Julio, Moberg, Dick, Moheet, Asma, Montalenti, Elisa, Monti, Martin, Morrison, Chris, Munar, Marina, Murtaugh, Brooke, Naccache, Lionel, Nagayama, Masao, Nairon, Emerson, Nakagawa, Thomas, Naldi, Andrea, Narenthiran, Ganesalingam, Natarajan, Girija, Nemetsky, Esther, Newcombe, Virginia, Nielsen, Niklas, Niznick, Naomi, Noronha-Falcão, Filipa, Nyquist, Paul, Olson, DaiWai, Othman, Marwan, Owen, Adrian, Padayachy, Llewellyn, Pajoumand, Mehrnaz, Park, Soojin, Pergakis, Melissa, Perry, Heidi, Polizzotto, Len, Pouratian, Nader, Spivack, Marilyn Price, Prisco, Lara, Provencio, Javier, Puglises, Francesco, Puybasset, Louis, Rao, Chethan, Rasmussen, Lindsay, Rasulo, Frank, Ray, Bappaditya, Ricci, Zaccaria, Richardson, Risa, Shinotsuka, Cassia Righy, Robba, Chiara, Robertson, Courtney, Rohaut, Benjamin, Rolston, John, Romagnoli, Stefano, Rosanova, Mario, Rosenthal, Eric, Rowe, Shaun, Rubin, Michael, Russell, Mary Beth, Silva, Gisele Sampaio, Sanz, Leandro, Sarasso, Simone, Sarwal, Aarti, Schiff, Nicolas, Schnakers, Caroline, Seder, David, Shah, Vishank Arun, Shapiro-Rosenbaubm, Amy, Shapshak, Angela, Sharma, Kartavya, Sharma, Kumar Ajay, Shutter, Lori, Sitt, Jacobo, Slomine, Beth, Smetana, Keaton, Smielewski, Peter, Smith, Wade, Stamatakis, Emmanuel, Steinberg, Alexis, Stevens, Robert, Suarez, Jose, Sung, Gene, Sussman, Bethany, Taran, Shaurya, Mazzeo, Anna Teresa, Thibaut, Aurore, Thompson, David, Threlkeld, Zachary, Toker, Daniel, Torbey, Michel, Tosto, Jenna, Trevick, Stephen, Tsaousi, Georgia, Turgeon, Alexis, Udy, Andrew, Varelas, Panos, Vespa, Paul, Videtta, Walter, Voss, Henning, Vox, Ford, Wagner, Amy, Wahlster, Sarah, Wainwright, Mark, Whyte, John, Witherspoon, Briana, Yakhkind, Aleksandra (Sasha), Yeager, Susan, Young, Michael, Zafar, Sahar, Zafonte, Ross, Zahuranec, Darin, Zammit, Chris, Zhang, Bei, Ziai, Wendy, Zimmerman, Lara, and Zink, Elizabeth
- Abstract
Disorders of consciousness are neurological conditions characterized by impaired arousal and awareness of self and environment. Behavioural responses are absent or are present but fluctuate. Disorders of consciousness are commonly encountered as a consequence of both acute and chronic brain injuries, yet reliable epidemiological estimates would require inclusive, operational definitions of the concept, as well as wider knowledge dissemination among involved professionals. Whereas several manifestations have been described, including coma, vegetative state/unresponsive wakefulness syndrome and minimally conscious state, a comprehensive neurobiological definition for disorders of consciousness is still lacking. The scientific literature is primarily observational, and studies-specific aetiologies lead to disorders of consciousness. Despite advances in these disease-related forms, there remains uncertainty about whether disorders of consciousness are a disease-agnostic unitary entity with a common mechanism, prognosis or treatment response paradigm. Our knowledge of disorders of consciousness has also been hampered by heterogeneity of study designs, variables, and outcomes, leading to results that are not comparable for evidence synthesis. The different backgrounds of professionals caring for patients with disorders of consciousness and the different goals at different stages of care could partly explain this variability. The Prospective Studies working group of the Neurocritical Care Society Curing Coma Campaign was established to create a platform for observational studies and future clinical trials on disorders of consciousness and coma across the continuum of care. In this narrative review, the author panel presents limitations of prior observational clinical research and outlines practical considerations for future investigations. A narrative review format was selected to ensure that the full breadth of study design considerations could be addressed and to facilit
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- 2024
34. Physician Transfer Versus Patient Transfer for Mechanical Thrombectomy in Patients With Acute Ischemic Stroke: A Systematic Review and Meta-Analysis.
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Qureshi, Adnan I., Lodhi, Abdullah, Maqsood, Hamza, Xiaoyu Ma, Hubert, Gordian J., Gomez, Camilo R., Kwok, Chun S., Ford, Daniel E., Hanley, Daniel F., Mehr, David R., Shah, Qaisar A., and Suri, M. Fareed K.
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- 2024
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35. Neonatal Survival After Serial Amnioinfusions for Bilateral Renal Agenesis: The Renal Anhydramnios Fetal Therapy Trial.
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Miller, Jena L., Baschat, Ahmet A., Rosner, Mara, Blumenfeld, Yair J., Moldenhauer, Julie S., Johnson, Anthony, Schenone, Mauro H., Zaretsky, Michael V., Chmait, Ramen H., Gonzalez, Juan M., Miller, Russell S., Moon-Grady, Anita J., Bendel-Stenzel, Ellen, Keiser, Amaris M., Avandhani, Radhika, Jelin, Angie C., Davis, Jonathan M., Warren, Daniel S., Hanley, Daniel F., and Watkins, Joslynn A.
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- 2024
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36. Mechanisms and benefits of cardiac rehabilitation in individuals with stroke: emerging role of its impact on improving cardiovascular and neurovascular health.
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Cuccurullo, Sara J., Fleming, Talya K., Petrosyan, Hayk, Hanley, Daniel F., and Raghavan, Preeti
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- 2024
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37. Mechanical thrombectomy in patients with acute ischemic stroke in the USA before and after time window expansion.
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Chun Shing Kwok, Gillani, Syed A., Bains, Navpreet K., Gomez, Camilo R., Hanley, Daniel F., Ford, Daniel E., Hassan, Ameer E., Thanh N. Nguyen, Siddiq, Farhan, Spiotta, Alejandro M., and Qureshi, Adnan I.
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HEALTH self-care ,INTRACRANIAL hemorrhage ,TREATMENT effectiveness ,DESCRIPTIVE statistics ,RETROSPECTIVE studies ,DISCHARGE planning ,HOSPITAL mortality ,LONGITUDINAL method ,SURGICAL complications ,ODDS ratio ,INTERNATIONAL relations ,ISCHEMIC stroke ,THROMBECTOMY ,COMPARATIVE studies ,CONFIDENCE intervals ,TIME ,HEMORRHAGE ,EVALUATION - Abstract
Background In 2018, the time window for mechanical thrombectomy eligibility in patients with acute ischemic stroke increased from within 6 hours to within 24 hours of symptom onset. The purpose of this study was to evaluate the effect of window expansion on procedural and hospital volumes and patient outcomes at a national level. Methods We conducted a retrospective cohort study of patients with acute ischemic stroke undergoing mechanical thrombectomy using data from the National Inpatient Sample. We compared the numbers of mechanical thrombectomy procedures and performing hospitals between 2017 and 2019 in the USA, and the proportion of patients discharged home/self-care, those with in-hospital mortality and post-procedural intracranial hemorrhage (2019 vs 2017) after adjustment for potential confounders. Results The number of patients with ischemic stroke who underwent mechanical thrombectomy increased from 16 960 in 2017 to 28 120 in 2019. There was an increase in the number of hospitals performing mechanical thrombectomy (501 in 2017, 585 in 2019) and those performing ≥50 procedures/year (97 in 2017, 199 in 2019; P<0.001). The odds of in-hospital mortality decreased (OR 0.79, 95% CI 0.66 to 0.94, P=0.008) and the odds of intracranial hemorrhage increased (OR 1.18, 95% CI 1.06 to 1.31, P=0.003) in 2019 compared with 2017, with no change in odds of discharge to home. Conclusions The window expansion for mechanical thrombectomy for patients with acute ischemic stroke was associated with an increase in the numbers of mechanical thrombectomy procedures and performing hospitals with a reduction of in-hospital mortality in the USA. [ABSTRACT FROM AUTHOR]
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- 2024
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38. Intraventricular Hemorrhage Expansion in the CLEAR III Trial: A Post Hoc Exploratory Analysis
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Roh, David J., Asonye, Ifeyinwa S., Carvalho Poyraz, Fernanda, Magid-Bernstein, Jessica R., Joiner, Evan F., Avadhani, Radhika, Awad, Issam, Hanley, Daniel F., Ziai, Wendy C., and Murthy, Santosh B.
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- 2022
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39. Rationale and Design of the mTECH‐Rehab Randomized Controlled Trial: Impact of a Mobile Technology Enabled Corrie Cardiac Rehabilitation Program on Functional Status and Cardiovascular Health
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Isakadze, Nino, primary, Kim, Chang H., additional, Marvel, Francoise A., additional, Ding, Jie, additional, MacFarlane, Zane, additional, Gao, Yumin, additional, Spaulding, Erin M., additional, Stewart, Kerry J., additional, Nimbalkar, Mansi, additional, Bush, Alexandra, additional, Broderick, Ashley, additional, Gallagher, Jeanmarie, additional, Molello, Nancy, additional, Commodore‐Mensah, Yvonne, additional, Michos, Erin D., additional, Dunn, Patrick, additional, Hanley, Daniel F., additional, McBee, Nichol, additional, Martin, Seth S., additional, and Mathews, Lena, additional
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- 2024
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40. Neonatal Survival After Serial Amnioinfusions for Bilateral Renal Agenesis
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Miller, Jena L., primary, Baschat, Ahmet A., additional, Rosner, Mara, additional, Blumenfeld, Yair J., additional, Moldenhauer, Julie S., additional, Johnson, Anthony, additional, Schenone, Mauro H., additional, Zaretsky, Michael V., additional, Chmait, Ramen H., additional, Gonzalez, Juan M., additional, Miller, Russell S., additional, Moon-Grady, Anita J., additional, Bendel-Stenzel, Ellen, additional, Keiser, Amaris M., additional, Avadhani, Radhika, additional, Jelin, Angie C., additional, Davis, Jonathan M., additional, Warren, Daniel S., additional, Hanley, Daniel F., additional, Watkins, Joslynn A., additional, Samuels, Joshua, additional, Sugarman, Jeremy, additional, and Atkinson, Meredith A., additional
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- 2023
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41. CSF and serum inflammatory response and association with outcomes in spontaneous intracerebral hemorrhage with intraventricular extension: an analysis of the CLEAR-III Trial
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Gusdon, Aaron M., Thompson, Carol B., Quirk, Kendel, Mayasi, Yunis M., Avadhani, Radhika, Awad, Issam A., Hanley, Daniel F., and Ziai, Wendy C.
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- 2021
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42. Advances in Therapeutic Approaches for Spontaneous Intracerebral Hemorrhage
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Al-Kawaz, Mais N., Hanley, Daniel F., and Ziai, Wendy
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- 2020
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43. Enhancing the Informed Consent Process Using Shared Decision Making and Consent Refusal Data from the CLEAR III Trial
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Porter, Amanda L., Ebot, James, Lane, Karen, Mooney, Lesia H., Lannen, Amy M., Richie, Eugene M., Dlugash, Rachel, Mayo, Steve, Brott, Thomas G., Ziai, Wendy, Freeman, William D., and Hanley, Daniel F.
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- 2020
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44. Correction to: Improved precision in the analysis of randomized trials with survival outcomes, without assuming proportional hazards
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Díaz, Iván, Colantuoni, Elizabeth, Hanley, Daniel F., and Rosenblum, Michael
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- 2020
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45. Hemorrhagic stroke
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Montaño, Arturo, primary, Hanley, Daniel F., additional, and Hemphill, J. Claude, additional
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- 2021
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46. Ultrastructural Characteristics of Neuronal Death and White Matter Injury in Mouse Brain Tissues After Intracerebral Hemorrhage: Coexistence of Ferroptosis, Autophagy, and Necrosis.
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Qian Li, Weiland, Abigail, Xuemei Chen, Xi Lan, Xiaoning Han, Durham, Frederick, Xi Liu, Jieru Wan, Ziai, Wendy C., Hanley, Daniel F., and Jian Wang
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CEREBRAL hemorrhage ,WHITE matter (Nerve tissue) ,CORPUS callosum ,ERYTHROCYTES ,BRAIN injuries - Abstract
Although intracerebral hemorrhage (ICH) is a devastating disease worldwide, the pathologic changes in ultrastructure during the acute and chronic phases of ICH are poorly described. In this study, transmission electron microscopy was used to examine the ultrastructure of ICH-induced pathology. ICH was induced in mice by an intrastriatal injection of collagenase. Pathologic changes were observed in the acute (3 days), subacute (6 days), and chronic (28 days) phases. Compared with sham animals, we observed various types of cell death in the injured striatum during the acute phase of ICH, including necrosis, ferroptosis, and autophagy. Different degrees of axon degeneration in the striatum were seen in the acute phase, and axonal demyelination was observed in the ipsilateral striatum and corpus callosum at late time points. In addition, phagocytes, resident microglia, and infiltrating monocyte-macrophages were present around red blood cells and degenerating neurons and were observed to engulf red blood cells and other debris. Many synapses appeared abnormal or were lost. This systematic analysis of the pathologic changes in ultrastructure after ICH in mice provides information that will be valuable for future ICH pathology studies. [ABSTRACT FROM AUTHOR]
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- 2024
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47. Computer-Supervised EVD Raises Safety Questions in ICU Care of IVH
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Hanley, Daniel F., primary, Ziai, Wendy C., additional, and Awad, Issam A., additional
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- 2023
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48. Reader Response: Functional Outcomes and Mortality in Patients With Intracerebral Hemorrhage After Intensive Medical and Surgical Support
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Shah, Vishank A., primary, Carhuapoma, Lourdes, additional, Hanley, Daniel F., additional, and Ziai, Wendy C., additional
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- 2023
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49. Transfusion reactions associated with COVID‐19 convalescent plasma in outpatient clinical trials
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Huaman, Moises A., primary, Raval, Jay S., additional, Paxton, James H., additional, Mosnaim, Giselle S., additional, Patel, Bela, additional, Anjan, Shweta, additional, Meisenberg, Barry R., additional, Levine, Adam C., additional, Marshall, Christi E., additional, Yarava, Anusha, additional, Shenoy, Aarthi G., additional, Heath, Sonya L., additional, Currier, Judith S., additional, Fukuta, Yuriko, additional, Blair, Janis E., additional, Spivak, Emily S., additional, Petrini, Joann R., additional, Broderick, Patrick B., additional, Rausch, William, additional, Cordisco, MarieElena, additional, Hammel, Jean, additional, Greenblatt, Benjamin, additional, Cluzet, Valerie C., additional, Cruser, Daniel, additional, Oei, Kevin, additional, Abinante, Matthew, additional, Hammitt, Laura L., additional, Sutcliffe, Catherine G., additional, Forthal, Donald N., additional, Zand, Martin S., additional, Cachay, Edward R., additional, Kassaye, Seble G., additional, Ram, Malathi, additional, Wang, Ying, additional, Das, Piyali, additional, Lane, Karen, additional, McBee, Nichol A., additional, Gawad, Amy L., additional, Karlen, Nicky, additional, Ford, Daniel E., additional, Laeyendecker, Oliver, additional, Pekosz, Andrew, additional, Klein, Sabra L., additional, Ehrhardt, Stephan, additional, Lau, Bryan, additional, Baksh, Sheriza N., additional, Shade, David M., additional, Casadevall, Arturo, additional, Hanley, Daniel F., additional, Ou, Jiangda, additional, Gniadek, Thomas J., additional, Ziman, Alyssa, additional, Shoham, Shmuel, additional, Gebo, Kelly A., additional, Bloch, Evan M., additional, Tobian, Aaron A. R., additional, Sullivan, David J., additional, and Gerber, Jonathan M., additional
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- 2023
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50. Cigarette Smoking as a Risk Factor for Hematoma Expansion in Primary Intracerebral Hemorrhage: Analysis From a Randomized Clinical Trial
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Schupper, Alexander J., primary, Khorasanizadeh, Mirhojjat, additional, Rossitto, Christina P., additional, Foster, Lydia D., additional, Kellner, Christopher P., additional, Suarez, Jose I., additional, Qureshi, Adnan I., additional, Majidi, Shahram, additional, Palesch, Yuko Y., additional, Martin, Renee L., additional, Barsan, William G., additional, Silbergleit, Robert, additional, Hanley, Daniel F., additional, Moy, Claudia S., additional, Hsu, Chung Y., additional, Steiner, Thorsten, additional, Toyoda, Kazunori, additional, Wang, Yongjun, additional, Yamamoto, Haruko, additional, and Yoon, Byung‐Woo, additional
- Published
- 2023
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