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529 results on '"Hankard, R."'

7. High burden of recurrent cardiovascular events in heterozygous familial hypercholesterolemia: The French Familial Hypercholesterolemia Registry

Author

Angoulvant, D., Béliard, S., Benlian, P., Boileau, C., Boccara, F., Bruckert, E., Cariou, B., Carreau, V., Carrié, A., Charrière, S., Di Filippo, M., Ducluzeau, P.H., Dulong, S., Durlach, V., Farnier, M., Ferrari, E., Ferrières, J., Gallo, A., Girardet, J.P., Hankard, R., Krempf, M., Lalau, J.D., Lefort, B., Lemale, J., Moulin, P., Paillard, F., Peretti, N., Pradignac, A., Pucheu, Y., Rabès, J.P., Saheb, S., Sultan, A., Tounian, P., Valéro, R., Varret, M., Vergès, B., Yelnik, C., Ziegler, O., Béliard, Sophie, Boccara, Franck, Cariou, Bertrand, Carrié, Alain, Collet, Xavier, Farnier, Michel, Ferrières, Jean, Krempf, Michael, Peretti, Noël, Rabès, Jean-Pierre, Varret, Mathilde, Vimont, Alexandre, Charrière, Sybil, and Bruckert, Eric

Published
2018
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10. Bonne réponse immunitaire humorale après vaccination contre le COVID-19 dans des populations particulières pédiatriques: cohorte observationnelle française

Author

Toubiana, J., primary, Guilmin-Crépon, S., additional, Kaguelidou, F., additional, Loubet, P., additional, Wittkop, L., additional, Hankard, R., additional, de Lamballerie, X., additional, Launay, O., additional, Basmaci, R., additional, and Cov-popart pediatric populations, A., additional

Published
2023
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11. Implementation of a centralized pharmacovigilance system in academic pan-European clinical trials: Experience from EU-Response and conect4children consortia

Author

Terzić, V., Levoyer, L., Figarella, M., Bigagli, E., Mercier, N., Gastines, L. De, Gibowski, S., Trøseid, M., Demotes, J., Olsen, I.C., Hites, M., Ader, F., Lopez, J.R.A., Mentré, F., Espérou, H., Costagliola, D., Røttingen, J.A., Poissy, J., Rozé, J.C., Warris, A., O'Leary, J., Fernandes, R.M., Assoumou, L., Hankard, R., Turner, M., Yazdanpanah, Y., Diallo, A., Terzić, V., Levoyer, L., Figarella, M., Bigagli, E., Mercier, N., Gastines, L. De, Gibowski, S., Trøseid, M., Demotes, J., Olsen, I.C., Hites, M., Ader, F., Lopez, J.R.A., Mentré, F., Espérou, H., Costagliola, D., Røttingen, J.A., Poissy, J., Rozé, J.C., Warris, A., O'Leary, J., Fernandes, R.M., Assoumou, L., Hankard, R., Turner, M., Yazdanpanah, Y., and Diallo, A.

Abstract

Contains fulltext : 292812.pdf (Publisher’s version ) (Open Access), Setting-up a high quality, compliant and efficient pharmacovigilance (PV) system in multi-country clinical trials can be more challenging for academic sponsors than for companies. To ensure the safety of all participants in academic studies and that the PV system fulfils all regulations, we set up a centralized PV system that allows sponsors to delegate work on PV. This initiative was put in practice by our Inserm-ANRS MIE PV department in two distinct multinational European consortia with 19 participating countries: conect4children (c4c) for paediatrics research and EU-Response for Covid-19 platform trials. The centralized PV system consists of some key procedures to harmonize the complex safety processes, creation of a local safety officer (LSO) network and centralization of all safety activities. The key procedures described the safety management plan for each trial and how tasks were shared and delegated between all stakeholders. Processing of serious adverse events (SAEs) in a unique database guaranteed the full control of the safety data and continuous evaluation of the risk-benefit ratio. The LSO network participated in efficient regulatory compliance across multiple countries. In total, there were 1312 SAEs in EU-Response and 83 SAEs in c4c in the four trials. We present here the lessons learnt from our experience in four clinical trials. We managed heterogeneous European local requirements and implemented efficient communication with all trial teams. Our approach builds capacity for PV that can be used by multiple academic sponsors.

Published
2023

12. The very high cardiovascular risk in heterozygous familial hypercholesterolemia: Analysis of 734 French patients

Author

Angoulvant, D., Béliard, S., Boccara, F., Bruckert, E., Durlach, V., Farnier, M., Ferrières, J., Hankard, R., Krempf, M., Lalau, J.D., Luc, G., Moulin, P., Paillard, F., Peretti, N., Pradignac, A., Pucheu, Y., Tounian, P., Vergès, B., Ziegler, O., Béliard, Sophie, Millier, Aurélie, Carreau, Valérie, Carrié, Alain, Moulin, Philippe, Fredenrich, Alexandre, Farnier, Michel, Luc, Gérald, Rosenbaum, David, Toumi, Mondher, and Bruckert, Eric

Published
2016
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13. Connaissances des adolescents atteints de maladie inflammatoire chronique intestinale : résultats d’une enquête transversale multicentrique

Author

Maignant, S., Pélatan, C., Breton, E., Cagnard, B., Chaillou, E., Giniès, J.-L., Le Hénaff, G., Ségura, J.-F., Willot, S., Bridoux, L., Jobert, A., Darviot, E., Delaperrière, N., Lapeyre, D., Carré, E., Grimal, I., Hankard, R., Wagner, A.-C., Balençon, M., Caldari, D., Tourtelier, Y., and Dabadie, A.

Published
2015
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14. To which extent social withdrawal at the age of 1 year is associated with IQ at 5–6 years old? Results of the EDEN mother–child cohort

Author

Guedeney, Antoine, Doukhan, Sarah, Forhan, Anne, Heude, Barbara, Peyre, Hugo, Annesi-Maesano, I., Bernard, J. Y., Botton, J., Charles, M. A., Dargent-Molina, P., de Lauzon-Guillain, B., Ducimetière, P., de Agostini, M., Foliguet, B., Forhan, A., Fritel, X., Germa, A., Goua, V., Hankard, R., Heude, B., Kaminski, M., Larroque, B., Lelong, N., Lepeule, J., Magnin, G., Marchand, L., Nabet, C., Pierre, F., Slama, R., Saurel-Cubizolles, M. J., Schweitzer, M., Thiebaugeorges, O., and On behalf of the EDEN Mother–Child Cohort Study Group

Published
2017
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15. Les enfants consomment-ils trop de sel ?

Author

Girardet, J.-P., Rieu, D., Bocquet, A., Bresson, J.-L., Briend, A., Chouraqui, J.-P., Darmaun, D., Dupont, C., Frelut, M.-L., Hankard, R., Goulet, O., Simeoni, U., Turck, D., and Vidailhet, M.

Published
2014
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22. Infant feeding patterns over the first year of life: influence of family characteristics

Author

Betoko, A., Charles, M.-A., Hankard, R., Forhan, A., Bonet, M., Saurel-Cubizolles, M.-J., Heude, B., and de Lauzon-Guillain, B.

Subjects
Infants -- Behavior -- Food and nutrition, Food habits -- Research, Food/cooking/nutrition, Health
Abstract

BACKGROUND/OBJECTIVES: Early eating patterns and behaviors can determine later eating habits and food preferences and they have been related to the development of childhood overweight and obesity. We aimed to identify patterns of feeding in the first year of life and to examine their associations with family characteristics. SUBJECTS/METHODS: Our analysis included 1004 infants from the EDEN mother-child cohort. Feeding practices were assessed through maternal self-report at birth, 4, 8 and 12 months. Principal component analysis was applied to derive patterns from breastfeeding duration, age at complementary food (CF) introduction and type of food used at 1 year. Associations between patterns and family characteristics were analyzed by linear regressions. RESULTS: The main source of variability in infant feeding was characterized by a pattern labeled 'late CF introduction and use of ready-prepared baby foods'. Older, more educated, primiparous women with high monthly income ranked high on this pattern. The second pattern, labeled 'longer breastfeeding, late CF introduction and use of home-made foods' was the closest to infant feeding guidelines. Mothers ranking high on this pattern were older and more educated. The third pattern, labeled 'use of adults' foods' suggests a less age-specific diet for the infants. Mothers ranking high on this pattern were often younger and multiparous. Recruitment center was related to all patterns. CONCLUSIONS: Not only maternal education level and age, but also parity and region are important contributors to the variability in patterns. Further studies are needed to describe associations between these patterns and infant growth and later food preferences. European Journal of Clinical Nutrition (2013) 67, 631-637; doi: 10.1038/ejcn.2012.200; published online 9 January 2013 Keywords: feeding patterns; home-made foods; ready-prepared foods; infants; sociodemographic factors, INTRODUCTION Obesity is a worldwide epidemic and numerous studies have focused on the identification of its early determinants. The early postnatal period appears to be a critical window of development. [...]

Published
2013
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23. Early Impact of Severe Acute Respiratory Syndrome Coronavirus 2 on Pediatric Clinical Research: A Pan-European and Canadian Snapshot in Time

Author

Mantha, O.L., Flamein, F., Turner, M.A., Wildt, S.N. de, Fernandes, R.M., Hankard, R., Mantha, O.L., Flamein, F., Turner, M.A., Wildt, S.N. de, Fernandes, R.M., and Hankard, R.

Abstract

Item does not contain fulltext, OBJECTIVE: To capture the early effects of the coronavirus disease 2019 (COVID-19) pandemic on pediatric clinical research. STUDY DESIGN: Pediatric clinical research networks from 20 countries and 50 of their affiliated research sites completed two surveys over one month from early May to early June 2020. Networks liaised with their affiliated sites and contributed to the interpretation of results through pan-European group discussions. Based on first detection dates of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), countries formed 1 early detecting and 1 late detecting cluster. We tested the hypothesis that this clustering influenced clinical research. RESULTS: Research sites were first impacted by the pandemic in mid-March 2020 (March 16 ± 10 days, the same date as lockdown initiation; P = .99). From first impact up until early June, site initiation and feasibility analysis processes were affected for >50% of the sites. Staff were redirected to COVID-19 research for 44% of the sites, and 75.5% of sites were involved in pediatric COVID-19 research (only 6.3% reported COVID-19 cases in their other pediatric trials). Mitigation strategies were used differently between the early and late detecting country clusters and between countries with and without a pediatric COVID-19 research taskforce. Positive effects include the development of teleworking capacities. CONCLUSIONS: Through this collaborative effort from pediatric research networks, we found that pediatric trials were affected and conducted with a range of unequally applied mitigations across countries during the pandemic. The global impact might be greater than captured. In a context where clinical research is increasingly multinational, this report reveals the importance of collaboration between national networks.

Published
2021

24. The conect4children (c4c) Consortium: Potential for Improving European Clinical Research into Medicines for Children

Author

Turner, M.A., Hildebrand, H., Fernandes, R.M., Wildt, S.N. de, Mahler, F., Hankard, R., Leary, R., Bonifazi, F., Nobels, P., Cheng, K., Attar, S., Rossi, P., Rocchi, F., Claverol, J., Nafria, B., Giaquinto, C., Turner, M.A., Hildebrand, H., Fernandes, R.M., Wildt, S.N. de, Mahler, F., Hankard, R., Leary, R., Bonifazi, F., Nobels, P., Cheng, K., Attar, S., Rossi, P., Rocchi, F., Claverol, J., Nafria, B., and Giaquinto, C.

Abstract

Contains fulltext : 232104.pdf (Publisher’s version ) (Open Access), The need for information about new and existing drugs used in children was recognized in the European Union (EU) with the implementation of the Paediatric Regulation in 2007. In 2017, the 10-year review of the Paediatric Regulation identified barriers to the conduct of clinical trials, including delays in setting up and completing paediatric trials. Across Europe, the difficulties with clinical research are compounded by variation within countries and between countries. Ethics and regulatory review have national specificities. This paper describes the Collaborative Network for European Clinical Trials for Children (conect4children, c4c), which addresses selected difficulties in the design and conduct of paediatric clinical trials. c4c is a time-limited public-private consortium funded by the Innovative Medicines Initiative (IMI2). The elements of c4c are as follows: expert advice providing input on study design and/or paediatric development programmes (including patient involvement activities); a network of sites following harmonised procedures coordinated by National Hubs and a single point of contact for Europe; a facility for education and training for sites and trial teams; and support for managing data used by the network and a common paediatric data dictionary. c4c does not sponsor trials. c4c is taking a phased approach with careful piloting through industry and non-industry studies intended to demonstrate the viability of the network (proof-of-viability studies). c4c uses a co-design approach involving industry and academics within a clearly defined scope. A sustainable, successor organization open to all potential service users will be open for business before the end of IMI2 funding in 2024.

Published
2021

32. The new European regulatory framework for infant and follow-on formulas: Comments from the Committee of Nutrition of the French Society of Pediatrics (CN-SFP)

Author

Bocquet, A., primary, Briend, A., additional, Chouraqui, J.-P., additional, Darmaun, D., additional, Feillet, F., additional, Frelut, M.-L., additional, Guimber, D., additional, Hankard, R., additional, Lapillonne, A., additional, Peretti, N., additional, Roze, J.-C., additional, Simeoni, U., additional, Turck, D., additional, and Dupont, C., additional

Published
2020
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34. Vegetarian diet in children and adolescents: A health benefit?

Author

Peretti, N., primary, Darmaun, D., additional, Chouraqui, J.P., additional, Bocquet, A., additional, Briend, A., additional, Feillet, F., additional, Frelut, M.L., additional, Guimber, D., additional, Hankard, R., additional, Lapillonne, A., additional, Rozé, J.C., additional, Simeoni, U., additional, Turck, D., additional, and Dupont, C., additional

Published
2020
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43. Cord-blood vitamin D level and night sleep duration in preschoolers in the EDEN mother-child birth cohort

Author

Yong, Chu Yan, primary, Reynaud, Eve, additional, Forhan, Anne, additional, Dargent-Molina, Patricia, additional, Heude, Barbara, additional, Charles, Marie-Aline, additional, Plancoulaine, Sabine, additional, Annesi-Maesano, I., additional, Bernard, J.Y., additional, Botton, J., additional, Charles, M.A., additional, Dargent-Molina, P., additional, de Lauzon-Guillain, B., additional, Ducimetière, P., additional, de Agostini, M., additional, Foliguet, B., additional, Forhan, A., additional, Fritel, X., additional, Germa, A., additional, Goua, V., additional, Hankard, R., additional, Heude, B., additional, Kaminski, M., additional, Larroque, B., additional, Lelong, N., additional, Lepeule, J., additional, Magnin, G., additional, Marchand, L., additional, Nabet, C., additional, Pierre, F., additional, Slama, R., additional, Saurel-Cubizolles, M.J., additional, Schweitzer, M., additional, and Thiebaugeorges, O., additional

Published
2019
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45. Early oral exposure to house dust mite allergen through breast milk: A potential risk factor for allergic sensitization and respiratory allergies in children

Author

Annesi-Maesano, I., Bernard, J.Y., Botton, J., Charles, M.A., Dargent-Molina, P., de Lauzon-Guillain, B., Ducimetière, P., de Agostini, M., Foliguet, B., Forhan, A., Fritel, X., Germa, A., Goua, V., Hankard, R., Heude, B., Kaminski, M., Larroque, B., Lelong, N., Lepeule, J., Magnin, G., Pierre, F., Marchand, L., Nabet, C., Slama, R., Saurel-Cubizolles, M.J., Schweitzer, M., Thiebaugeorges, O., Baïz, Nour, Macchiaverni, Patricia, Tulic, Meri K., Rekima, Akila, Annesi-Maesano, Isabella, and Verhasselt, Valérie

Published
2017
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48. Lipid intake in children under 3years of age in France. A position paper by the Committee on Nutrition of the French Society of Paediatrics

Author

Comité de nutrition de la Société française de pédiatrie, ., Briend, André, Legrand, P., Bocquet, A., Girardet, J. -P., Bresson, J. -L., Chouraqui, Jean Pierre, Darmaun, Dominique, Dupont, C., Frelut, M. L., Goulet, O., Hankard, R., Rieu, D., Simeoni, U., Turck, D., Vidailhet, Michel, Société Française de Pédiatrie (SFP), Institut de Recherche pour le Développement (IRD), Institut National de la Recherche Agronomique (INRA), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC), Université Pierre et Marie Curie - Paris 6 (UPMC), Université Paris Descartes - Paris 5 (UPD5), Université Joseph Fourier - Grenoble 1 (UJF), LUNAM Université [Nantes Angers Le Mans], AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), U1069, Institut National de la Santé et de la Recherche Médicale (INSERM), Université Montpellier 1 (UM1), Université de la Méditerranée - Aix-Marseille 2, Université de Lille, Droit et Santé, and Université de Lorraine (UL)

Subjects
Pediatrics, 030309 nutrition & dietetics, [SDV]Life Sciences [q-bio], Breastfeeding, INFANTS, Recommended Dietary Allowances, Occupational safety and health, chemistry.chemical_compound, MILK, 0302 clinical medicine, Societies, Medical, POLYUNSATURATED FATTY-ACIDS, 2. Zero hunger, chemistry.chemical_classification, 0303 health sciences, Arachidonic Acid, CHOLESTEROL, MOTHERS, WOMEN, food and beverages, LINOLEIC-ACID, Lipids, LONG-CHAIN OMEGA-3-FATTY-ACIDS, Eicosapentaenoic acid, 3. Good health, Eicosapentaenoic Acid, Docosahexaenoic acid, Child, Preschool, Fatty Acids, Unsaturated, lipids (amino acids, peptides, and proteins), Arachidonic acid, France, Child Nutritional Physiological Phenomena, Polyunsaturated fatty acid, medicine.medical_specialty, Docosahexaenoic Acids, Linoleic acid, Nutritional Status, World Health Organization, Reference Daily Intake, DIET, 03 medical and health sciences, 030225 pediatrics, medicine, Humans, business.industry, LIFE, chemistry, Pediatrics, Perinatology and Child Health, Energy Intake, business
Abstract

International audience; Lipids are an important source of energy for young children and play a major role in the development and functioning of nervous tissue. Essential fatty acids and their long-chain derivatives also fulfill multiple metabolic functions and play a role in the regulation of numerous genes. The Food and Agriculture Organization of the United Nations (FAO), the World Health Organization (WHO), and the French Agency for Food, Environmental and Occupational Health & Safety (Agence nationale de securite sanitaire de rahmentation, de l'environnement et du travail [ANSES]) have recently recommended a minimum daily intake in preformed long-chain polyunsaturated fatty acids (LC-PUFAs): arachidonic acid (ARA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). Mother's milk remains the only reference, but the large variability in its DHA content does not guarantee that breastfed children receive an optimal DHA intake if the mother's intake is insufficient. For children fed with infant formulas, ARA and DHA intake is often below the recommended intake because only one-third of infant formulas available on the market in France are enriched in LC-PUFAs. For all children, linoleic acid (LA) intake is on average higher than the minimal recommended values. The consequences of these differences between intake and recommended values are uncertain. A cautious attitude is to come close to the current recommendations and to advise sufficient consumption of DHA in breastfeeding women. For bottle-fed children, infant formulas enriched in LC-PUFAs and with moderate levels of LA should be preferred. LC-PUFA-rich fish should be consumed during breastfeeding, and adapted vegetable oils when complementary foods are introduced. (C) 2014 Elsevier Masson SAS. All rights reserved.

Published
2014

49. Postpartum psychological distress associated with anal incontinence in the EDEN mother-child cohort.

Author

Fritel, X, Gachon, B, Saurel‐Cubizolles, MJ, Annesi‐Maesano, I, Bernard, JY, Botton, J, Charles, MA, Dargent‐Molina, P, de Lauzon‐Guillain, B, Ducimetière, P, de Agostini, M, Foliguet, B, Forhan, A, Germa, A, Goua, V, Hankard, R, Heude, B, Kaminski, M, Larroque, B, and Lelong, N

Subjects
PSYCHOLOGICAL distress, POSTPARTUM depression, HOSPITAL wards, MENTAL health, WOMEN'S hospitals, PRENATAL depression
Abstract

Objective: To estimate the prevalence of flatus-only and faecal incontinence, to describe their risk factors and to analyse the association between anal incontinence and psychological distress over the first year postpartum.Design: Cohort study from pregnancy to 12 months postpartum.Setting: Two university hospital maternity wards in France.Population: A total of 2002 pregnant women were recruited between 2003 and 2006. Data on anal incontinence were available for the 1632 women who comprise the sample for analysis.Methods: Women were enrolled during pregnancy. A postal questionnaire was sent at 4 and 12 months postpartum.Main Outcome Measures: Anal (flatus-only and faecal) incontinence was assessed at 4 months postpartum. Mental health was assessed at 4 and 12 months postpartum by the Edinburgh Postpartum Depression Scale (EPDS) and use of antidepressant drugs as well as by self-rated mental health.Results: At 4 months postpartum, the prevalence for flatus-only incontinence was 14.4% and for faecal incontinence 1.7%; multivariate analysis, restricted to women reporting no anal incontinence before the index pregnancy, showed that continuing breastfeeding at 4 months was related to a higher risk of de novo postpartum anal incontinence (OR = 2.23). Women who reported anal incontinence at 4 months were more frequently depressed (EPDS ≥10 or antidepressant use) at 12 months postpartum: 36.0% of those with faecal incontinence were depressed, 23.3% of those with flatus-only incontinence and only 14.8% of the continent women.Conclusion: Postnatal faecal incontinence was rare but associated with poorer maternal mental health. Postnatal screening should be encouraged, and psychological support offered.Tweetable Abstract: Postnatal faecal incontinence was associated with depression; postnatal screening should be encouraged and psychological support offered. [ABSTRACT FROM AUTHOR]

Published
2020
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