Search

Laboratory education is a defining feature of chemistry degree courses, with one of the fundamental aims being acquiring competency in a range of chemistry-specific practical skills, yet there are still limited reports of direct assessment of these skills. Here, we present the development, implementation, and evaluation of a station-based practical chemistry exam for first year undergraduate students. We have designed the exam to explicitly assess a range of practical chemistry skills that we highlighted as being essential for subsequent chemistry laboratory work in our degree program, including many final year independent research projects. Details are provided on the logistics of implementing this exam, which has run for cohorts of 50-120 and is suitable for cohorts of up to 200 students. Introducing the practical exam into our course has received positive feedback from both staff and students and has contributed to increased motivation to learn and retain practical chemistry skills.

Objective Multiple sclerosis (MS) is a debilitating inflammatory and neurodegenerative disease which commonly involves cognitive dysfunction. Magnetic resonance imaging (MRI) studies have shown that patients with MS (pwMS) have diffuse patterns of brain atrophy, however, the relationship between the presentation of cognitive dysfunction and brain tissue loss remains understudied. Given the integral function of thalamus as a central nervous system relay center and its involvement in various brain circuits, thalamic atrophy may play a key role in the development and progression of cognitive dysfunction. The purpose of this study is to examine the relationship between cognitive impairment in pwMS and thalamic atrophy. Methods A total of 121 pwMS who had neuropsychological testing and quantitative MRI within 1 year of each were retrospectively identified. Grouped LASSO linear regression with 10-fold cross validation was used to estimate each neuropsychological test score with thalamic volume as the focal predictor and all other demographic and MRI metrics as covariates. Results Rates of impairment ranged from 19% to 44%. Results showed notable associations between thalamic volume and Symbol Digit Modalities Test (β  = 0.11), Brief Visuospatial Memory Test, delayed (β  = 0.12), California Verbal Learning Test, delayed and total (β  = 0.24 and β  = 0.15 respectively), and Trail Making Test Part A (β  = −0.01), after adjusting for covariates. Conclusions These findings demonstrate an independent association between thalamic volumes and processing speed and memory performance, after accounting for demographic, clinical, and other MRI variables, among pwMS. [ABSTRACT FROM AUTHOR]

INTRODUCTION: We aimed to assess whether midlife sensory and motor functions improve risk prediction of 10‐year cognitive decline and impairment when added to risk prediction models using the Cardiovascular Risk Factors, Aging, and Incidence of Dementia Score (CAIDE) and Framingham Risk Score (FRS). METHODS: Longitudinal data of N = 1529 (mean age 49 years; 54% women) Beaver Dam Offspring Study (BOSS) participants from baseline, 5 and 10‐year follow‐up were included. We tested whether including baseline sensory (hearing, vision, olfactory) impairment and motor function improves CAIDE or FRS risk predictions of 10‐year cognitive decline or cognitive impairment incidence using logistic regressions. RESULTS: Adding sensory and motor measures to CAIDE‐only and FRS‐only models significantly improved areas under the curve for cognitive decline and impairment models. DISCUSSION: Including midlife sensory and motor function improved risk predictions of long‐term cognitive decline and impairment in middle‐aged to older adults. Sensory and motor assessments could contribute to cost‐effective and non‐invasive screening tools that identify high‐risk individuals earlier to target intervention and prevention strategies. Highlights: Sensory and motor measures improve risk prediction models of cognitive decline.Sensory and motor measures improve risk prediction models of cognitive impairment.Prediction improvements were strongest in midlife (adults < 55 years of age).Sensory and motor changes may help identify high‐risk individuals early. [ABSTRACT FROM AUTHOR]

Background: Characterization of cognitive impairment (CI) in multiple sclerosis into distinct phenotypes holds promise for individualized treatments and biomarker exploration. Objective: Apply a previously validated, neuropsychologically driven diagnostic algorithm to identify a taxonomy of the type of cognitive phenotypes in multiple sclerosis. Methods: An algorithm developed and validated in other neurological diseases was applied to a cohort of 1281 people with multiple sclerosis who underwent clinical neuropsychological evaluation across three multiple sclerosis centers. A domain was marked impaired if scores on two tests within the domain fell below one of the two thresholds of interest (compared to controls; −1.0 SD and −1.5 SD below the mean). Results were then tabulated for each participant to determine the type of impairments across the sample. Results: At −1 SD threshold, 48.7% were intact, 21.6% had single-domain, 14.3% bi-domain, and 15.4% multi-domain impairment. At −1.5 SD threshold, 72.9% were intact, 14.0% had single-domain, 8.2% bi-domain, and 5.0% multi-domain impairment. Processing speed was the most frequent single-domain impairment, followed by executive function and memory. Conclusions: These findings advance the taxonomy of cognitive phenotypes in multiple sclerosis and clarify the type and distribution of possible cognitive diagnoses, pave the way for further investigation of associated biomarkers, and provide clinically meaningful information to guide individualized treatment and rehabilitation. [ABSTRACT FROM AUTHOR]

Background: There are reported variations in the intraoperative management of Crohn's disease. This consensus statement aimed to develop a standardised protocol for photographic documentation of intraoperative findings and critical procedural steps in ileocolonic Crohn's disease surgery. Methods: Colorectal surgeons with a specialist interest in minimally invasive surgery and inflammatory bowel disease were invited as committee members to develop a survey on the use of photo‐documentation in Crohn's disease surgery. A 15 item survey was developed on ethical considerations and applications of photo‐documentation in audit and quality control, research, and training. Results: There was strong agreement on the potential application of intraoperative photo‐documentation in Crohn's disease for training, research, quality control and tertiary referrals. Reviewers agreed that intraoperative staging required photo‐documentation of strictures, skip lesions, perforations, fat wrapping and mesenteric disease. The necessary steps to be photo‐documented were very specific to Crohn's disease surgery, such as views of anastomosis and strictureplasties, and extent of resection(s). Conclusions: Our consensus statement identified several items for appropriate intraoperative photo‐documentation in Crohn's disease surgery, to be used as an adjunct to accurate annotation of intraoperative findings and procedures. [ABSTRACT FROM AUTHOR]