Yoonjung Lee, Seung Ji Kang, Soo-yeun Kim, Sun A Kim, Hanbich Hong, Seong Ryeong Choi, Hae-Young Na, Kyung-Hwa Park, Min-Ho Shin, Sun-Seog Kweon, and Sook In Jung
배경 Immunity of healthcare workers to vaccine-preventable diseases is important to prevent hospital outbreak. We evaluated the sero-epidemiology of hepatitis A virus (HAV) infection and measles in sec- ondary hospitals workers in South Korea. 방법 Serum sample were collected from hospital workers in 28 secondary hospitals with 100-300 beds, lo- cated in Jeollanam-do South Korea in 2019. Chemiluminescent immunoassay was used for testing of im- munoglobulin G (IgG) antibodies to HAV and measles. 결과 Of total 2,573 hospital workers who were tested for HAV Ig G, 7% were physicians, 54% nurses, 19% nurse aides and 20% paramedical technicians. The overall HAV seropositivity rate was 43.3%. There were significant differences in HAV seropositivity between age groups (P < 0.001): 37.6% for < 25 years, 26.5% for 25-29 years, 25.2% for 30-34 years, 33.3% for 35-39 years, 61.5% for 40-44, and 88.8% for ≥45 years. Among those aged under <40 years old, seroprevalance was significantly lower in nurse aides (23.2%) and paramedical technicians (21.8%) compared to physicians (48.0%) and nurses (33.7%) (P < 0.001). Measles IgG test were performed in 2,068 hospital workers (6% physician, 53% nurse, 20% nurses’ aides and 21% paramedical technicians). The overall positivity of measles Ig G was 90.9%. The seropositivity for measles significantly increased with age (P < 0.001): 75.2% for < 25 years, 89.6% for 25-29 years, 98.1% for 30-34 years, 92.4% for 35-39 years, 97.4% for 40-44, and 97.7% for ≥45 years. There was no significant differences in measles immunity between occupations. 결론 Our findings suggest the need to augment appropriate vaccine programs for young hospital workers in South Korea. [ABSTRACT FROM AUTHOR]