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1. Novel RNA aptamers targeting gastrointestinal cancer biomarkers CEA, CA50 and CA72-4 with superior affinity and specificity

Author: Pan, Qing, primary, Law, Carmen OK, additional, Yung, Mingo MH, additional, Han, KC, additional, Pon, YL, additional, and Lau, Terrence CK, additional
Published: 2018
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2. Electron and Positron Fluxes in Primary Cosmic Rays Measured with the Alpha Magnetic Spectrometer on the International Space Station

Author: Aguilar, M, Aisa, D, Alvino, A, Ambrosi, Giovanni, Andeen, K, Arruda, L, Attig, N, Azzarello, P, Bachlechner, A, Barao, F, Barrau, A, Barrin, L, Bartoloni, A, Basara, L, Battarbee, M, Battiston, R, Bazo, J, Becker, U, Behlmann, M, Beischer, B, Berdugo, J, Bertucci, Bruna, Bigongiari, G, Bindi, V, Bizzaglia, S, Bizzarri, M, Boella, G, de Boer, W, Bollweg, K, Bonnivard, V, Borgia, B, Borsini, S, Boschini, Mj, Bourquin, M, Burger, J, Cadoux, F, Cai, Xd, Capell, M, Caroff, S, Casaus, J, Cascioli, V, Castellini, G, Cernuda, I, Cervelli, F, Chae, Mj, Chang, Yh, Chen, Ai, Chen, H, Cheng, Gm, Chen, Hs, Cheng, L, Chikanian, A, Chou, Hy, Choumilov, E, Choutko, V, Chung, Ch, Clark, C, Clavero, R, Coignet, G, Consolandi, C, Contin, A, Corti, C, Coste, B, Cui, Z, Dai, M, Delgado, C, Della Torre, S, Demirköz, Mb, Derome, L, Di Falco, S, Di Masso, L, Dimiccoli, F, Díaz, C, von Doetinchem, P, Du, Wj, Duranti, Matteo, D'Urso, D, Eline, A, Eppling, Fj, Eronen, T, Fan, Yy, Farnesini, L, Feng, J, Fiandrini, Emanuele, Fiasson, A, Finch, E, Fisher, P, Galaktionov, Y, Gallucci, G, García, B, García López, R, Gast, H, Gebauer, I, Gervasi, M, Ghelfi, A, Gillard, W, Giovacchini, F, Goglov, P, Gong, J, Goy, C, Grabski, V, Grandi, D, Graziani, Maura, Guandalini, C, Guerri, I, Guo, Kh, Habiby, M, Haino, S, Han, Kc, He, Zh, Heil, M, Hoffman, J, Hsieh, Th, Huang, Zc, Huh, C, Incagli, M, Ionica, Maria, Jang, Wy, Jinchi, H, Kanishev, K, Kim, Gn, Kim, Ks, Kirn, T, Kossakowski, R, Kounina, O, Kounine, A, Koutsenko, V, Krafczyk, Ms, Kunz, S, La Vacca, G, Laudi, E, Laurenti, G, Lazzizzera, I, Lebedev, A, Lee, Ht, Lee, Sc, Leluc, C, Li, Hl, Li, Jq, Li, Q, Li, Tx, Li, W, Li, Y, Li, Zh, Li, Zy, Lim, S, Lin, Ch, Lipari, P, Lippert, T, Liu, D, Liu, H, Lomtadze, T, Lu, Mj, Lu, Ys, Luebelsmeyer, K, Luo, F, Luo, Jz, Lv, Ss, Majka, R, Malinin, A, Mañá, C, Marín, J, Martin, T, Martínez, G, Masi, N, Maurin, D, Menchaca Rocha, A, Meng, Q, Mo, Dc, Morescalchi, L, Mott, P, Müller, M, Ni, Jq, Nikonov, N, Nozzoli, F, Nunes, P, Obermeier, A, Oliva, A, Orcinha, M, Palmonari, F, Palomares, C, Paniccia, M, Papi, A, Pedreschi, E, Pensotti, S, Pereira, R, Pilo, F, Piluso, A, Pizzolotto, C, Plyaskin, V, Pohl, M, Poireau, V, Postaci, E, Putze, A, Quadrani, L, Qi, Xm, Rancoita, Pg, Rapin, D, Ricol, Js, Rodríguez, I, Rosier Lees, S, Rozhkov, A, Rozza, D, Sagdeev, R, Sandweiss, J, Saouter, P, Sbarra, C, Schael, S, Schmidt, Sm, Schuckardt, D, von Dratzig AS, Schwering, G, Scolieri, G, Seo, Es, Shan, Bs, Shan, Yh, Shi, Jy, Shi, Xy, Shi, Ym, Siedenburg, T, Son, D, Spada, F, Spinella, F, Sun, W, Sun, Wh, Tacconi, M, Tang, Cp, Tang, Xw, Tang, Zc, Tao, L, Tescaro, D, Ting, Sc, Ting, Sm, Tomassetti, Nicola, Torsti, J, Türkoğlu, C, Urban, T, Vagelli, Valerio, Valente, E, Vannini, C, Valtonen, E, Vaurynovich, S, Vecchi, M, Velasco, M, Vialle, Jp, Wang, Lq, Wang, Ql, Wang, Rs, Wang, X, Wang, Zx, Weng, Zl, Whitman, K, Wienkenhöver, J, Wu, H, Xia, X, Xie, M, Xie, S, Xiong, Rq, Xin, Gm, Xu, Ns, Xu, W, Yan, Q, Yang, J, Yang, M, Ye, Qh, Yi, H, Yu, Yj, Yu, Zq, Zeissler, S, Zhang, Jh, Zhang, Mt, Zhang, Xb, Zhang, Z, Zheng, Zm, Zhuang, Hl, Zhukov, V, Zichichi, A, Zimmermann, N, Zuccon, P, Zurbach, C, Pauluzzi, Michele, Azzarello, Philipp, Bourquin, Maurice, Cadoux, Franck, Habiby Alaoui, Marion, Leluc, Catherine, Li, Yang, Paniccia, Mercedes, Pohl, Martin, Rapin, Divic Jean, Saouter, Pierre, Centro de Investigaciones Energéticas Medioambientales y Tecnológicas [Madrid] (CIEMAT), Istituto Nazionale di Fisica Nucleare, Sezione di Perugia (INFN, Sezione di Perugia), Istituto Nazionale di Fisica Nucleare (INFN), Institute of Nanotechnology [Karlsruhe] (INT), Karlsruhe Institute of Technology (KIT), Jülich Aachen Research Alliance (JARA), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), CERN [Genève], Istituto Nazionale di Fisica Nucleare, Sezione di Roma 3 (INFN, Sezione di Roma 3), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), University of Turku, Università degli Studi di Trento (UNITN), Department of Applied Mathematics (MIT), Massachusetts Institute of Technology (MIT), INFN Sezione di Pisa (INFN Sezione di Pisa), University of Hawai'i [Honolulu] (UH), Istituto Nazionale di Fisica Nucleare, Sezione di Milano (INFN), Karlsruher Institut für Technologie (KIT), NASA Johnson Space Center (JSC), NASA, Département de Physique Nucléaire et Corpusculaire [Genève] (DPNC), Université de Genève (UNIGE), CNR Istituto di Geoscienze e Georisorse [Firenze] (IGG), Consiglio Nazionale delle Ricerche (CNR), University of Pisa - Università di Pisa, EWHA Womans University (EWHA), National Central University [Taiwan] (NCU), Institute of High Energy Physics (IHEP), Chinese Academy of Sciences [Changchun Branch] (CAS), Shandong University, Yale University [New Haven], Istituto Nazionale di Fisica Nucleare, Sezione di Bologna (INFN, Sezione di Bologna), Laboratoire Univers et Particules de Montpellier (LUPM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Montpellier 2 - Sciences et Techniques (UM2), AMS, Aguilar, M, Aisa, D, Alvino, A, Ambrosi, G, Andeen, K, Arruda, L, Attig, N, Azzarello, P, Bachlechner, A, Barao, F, Barrau, A, Barrin, L, Bartoloni, A, Basara, L, Battarbee, M, Battiston, R, Bazo, J, Becker, U, Behlmann, M, Beischer, B, Berdugo, J, Bertucci, B, Bigongiari, G, Bindi, V, Bizzaglia, S, Bizzarri, M, Boella, G, de Boer, W, Bollweg, K, Bonnivard, V, Borgia, B, Borsini, S, Boschini, M, Bourquin, M, Burger, J, Cadoux, F, Cai, X, Capell, M, Caroff, S, Casaus, J, Cascioli, V, Castellini, G, Cernuda, I, Cervelli, F, Chae, M, Chang, Y, Chen, A, Chen, H, Cheng, G, Cheng, L, Chikanian, A, Chou, H, Choumilov, E, Choutko, V, Chung, C, Clark, C, Clavero, R, Coignet, G, Consolandi, C, Contin, A, Corti, C, Coste, B, Cui, Z, Dai, M, Delgado, C, Della Torre, S, Demirköz, M, Derome, L, Di Falco, S, Di Masso, L, Dimiccoli, F, Díaz, C, von Doetinchem, P, Du, W, Duranti, M, D’Urso, D, Eline, A, Eppling, F, Eronen, T, Fan, Y, Farnesini, L, Feng, J, Fiandrini, E, Fiasson, A, Finch, E, Fisher, P, Galaktionov, Y, Gallucci, G, García, B, García López, R, Gast, H, Gebauer, I, Gervasi, M, Ghelfi, A, Gillard, W, Giovacchini, F, Goglov, P, Gong, J, Goy, C, Grabski, V, Grandi, D, Graziani, M, Guandalini, C, Guerri, I, Guo, K, Habiby, M, Haino, S, Han, K, He, Z, Heil, M, Hoffman, J, Hsieh, T, Huang, Z, Huh, C, Incagli, M, Ionica, M, Jang, W, Jinchi, H, Kanishev, K, Kim, G, Kim, K, Kirn, T, Kossakowski, R, Kounina, O, Kounine, A, Koutsenko, V, Krafczyk, M, Kunz, S, LA VACCA, G, Laudi, E, Laurenti, G, Lazzizzera, I, Lebedev, A, Lee, H, Lee, S, Leluc, C, Li, H, Li, J, Li, Q, Li, T, Li, W, Li, Y, Li, Z, Lim, S, Lin, C, Lipari, P, Lippert, T, Liu, D, Liu, H, Lomtadze, T, Lu, M, Lu, Y, Luebelsmeyer, K, Luo, F, Luo, J, Lv, S, Majka, R, Malinin, A, Mañá, C, Marín, J, Martin, T, Martínez, G, Masi, N, Maurin, D, Menchaca Rocha, A, Meng, Q, Mo, D, Morescalchi, L, Mott, P, Müller, M, Ni, J, Nikonov, N, Nozzoli, F, Nunes, P, Obermeier, A, Oliva, A, Orcinha, M, Palmonari, F, Palomares, C, Paniccia, M, Papi, A, Pedreschi, E, Pensotti, S, Pereira, R, Pilo, F, Piluso, A, Pizzolotto, C, Plyaskin, V, Pohl, M, Poireau, V, Postaci, E, Putze, A, Quadrani, L, Qi, X, Rancoita, P, Rapin, D, Ricol, J, Rodríguez, I, Rosier Lees, S, Rozhkov, A, Rozza, D, Sagdeev, R, Sandweiss, J, Saouter, P, Sbarra, C, Schael, S, Schmidt, S, Schuckardt, D, von Dratzig, A, Schwering, G, Scolieri, G, Seo, E, Shan, B, Shan, Y, Shi, J, Shi, X, Shi, Y, Siedenburg, T, Son, D, Spada, F, Spinella, F, Sun, W, Tacconi, M, Tang, C, Tang, X, Tang, Z, Tao, L, Tescaro, D, Ting, S, Tomassetti, N, Torsti, J, Türkoğlu, C, Urban, T, Vagelli, V, Valente, E, Vannini, C, Valtonen, E, Vaurynovich, S, Vecchi, M, Velasco, M, Vialle, J, Wang, L, Wang, Q, Wang, R, Wang, X, Wang, Z, Weng, Z, Whitman, K, Wienkenhöver, J, Wu, H, Xia, X, Xie, M, Xie, S, Xiong, R, Xin, G, Xu, N, Xu, W, Yan, Q, Yang, J, Yang, M, Ye, Q, Yi, H, Yu, Y, Yu, Z, Zeissler, S, Zhang, J, Zhang, M, Zhang, X, Zhang, Z, Zheng, Z, Zhuang, H, Zhukov, V, Zichichi, A, Zimmermann, N, Zuccon, P, Zurbach, C, M. Aguilar, D. Aisa, A. Alvino, G. Ambrosi, K. Andeen, L. Arruda, N. Attig, P. Azzarello, A. Bachlechner, F. Barao, A. Barrau, L. Barrin, A. Bartoloni, L. Basara, M. Battarbee, R. Battiston, J. Bazo, U. Becker, M. Behlmann, B. Beischer, J. Berdugo, B. Bertucci, G. Bigongiari, V. Bindi, S. Bizzaglia, M. Bizzarri, G. Boella, W. d. Boer, K. Bollweg, V. Bonnivard, B. Borgia, S. Borsini, M. J. Boschini, M. Bourquin, J. Burger, F. Cadoux, X. D. Cai, M. Capell, S. Caroff, J. Casau, V. Cascioli, G. Castellini, I. Cernuda, F. Cervelli, M. J. Chae, Y. H. Chang, A. I. Chen, H. Chen, G. M. Cheng, H. S. Chen, L. Cheng, A. Chikanian, H. Y. Chou, E. Choumilov, V. Choutko, C. H. Chung, C. Clark, R. Clavero, G. Coignet, C. Consolandi, A. Contin, C. Corti, B. Coste, Z. Cui, M. Dai, C. Delgado, S. D. Torre, M. B. Demirkoz, L. Derome, S. D. Falco, L. D. Masso, F. Dimiccoli, C. Diaz, P. v. Doetinchem, W. J. Du, M. Duranti, D. D'Urso, A. Eline, F. J. Eppling, T. Eronen, Y. Y. Fan, L. Farnesini, J. Feng, E. Fiandrini, A. Fiasson, E. Finch, P. Fisher, Y. Galaktionov, G. Gallucci, B. Garcia, R. Garcia-Lopez, H. Gast, I. Gebauer, M. Gervasi, A. Ghelfi, W. Gillard, F. Giovacchini, P. Goglov, J. Gong, C. Goy, V. Grabski, D. Grandi, M. Graziani, C. Guandalini, I. Guerri, K. H. Guo, M. Habiby, S. Haino, K. C. Han, Z. H. He, M. Heil, J. Hoffman, T. H. Hsieh, Z. C. Huang, C. Huh, M. Incagli, M. Ionica, W. Y. Jang, H. Jinchi, K. Kanishev, G. N. Kim, K. S. Kim, T. Kirn, R. Kossakowski, O. Kounina, A. Kounine, V. Koutsenko, M. S. Krafczyk, S. Kunz, G. L. Vacca, E. Laudi, G. Laurenti, I. Lazzizzera, A. Lebedev, H. T. Lee, S. C. Lee, C. Leluc, H. L. Li, J. Q. Li, Q. Li, T. X. Li, W. Li, Y. Li, Z. H. Li, Z. Y. Li, S. Lim, C. H. Lin, P. Lipari, T. Lippert, D. Liu, H. Liu, T. Lomtadze, M. J. Lu, Y. S. Lu, K. Luebelsmeyer, F. Luo, J. Z. Luo, S. S. Lv, R. Majka, A. Malinin, C. Mana, J. Marin, T. Martin, G. Martinez, N. Masi, D. Maurin, A. Menchaca-Rocha, Q. Meng, D. C. Mo, L. Morescalchi, P. Mott, M. Muller, J. Q. Ni, N. Nikonov, F. Nozzoli, P. Nune, A. Obermeier, A. Oliva, M. Orcinha, F. Palmonari, C. Palomare, M. Paniccia, A. Papi, E. Pedreschi, S. Pensotti, R. Pereira, F. Pilo, A. Piluso, C. Pizzolotto, V. Plyaskin, M. Pohl, V. Poireau, E. Postaci, A. Putze, L. Quadrani, X. M. Qi, P. G. Rancoita, D. Rapin, J. S. Ricol, I. Rodriguez, S. Rosier-Lee, A. Rozhkov, D. Rozza, R. Sagdeev, J. Sandwei, P. Saouter, C. Sbarra, S. Schael, S. M. Schmidt, D. Schuckardt, A. S. von, G. Schwering, G. Scolieri, E. S. Seo, B. S. Shan, Y. H. Shan, J. Y. Shi, X. Y. Shi, Y. M. Shi, T. Siedenburg, D. Son, F. Spada, F. Spinella, W. Sun, W. H. Sun, M. Tacconi, C. P. Tang, X. W. Tang, Z. C. Tang, L. Tao, D. Tescaro, S. C. C., S. M. Ting, N. Tomassetti, J. Torsti, C. Turkoglu, T. Urban, V. Vagelli, E. Valente, C. Vannini, E. Valtonen, S. Vaurynovich, M. Vecchi, M. Velasco, J. P. Vialle, L. Q. Wang, Q. L. Wang, R. S. Wang, X. Wang, Z. X. Wang, Z. L. Weng, K. Whitman, J. Wienkenhover, H. Wu, X. Xia, M. Xie, S. Xie, R. Q. Xiong, G. M. Xin, N. S. Xu, W. Xu, Q. Yan, J. Yang, M. Yang, Q. H. Ye, H. Yi, Y. J. Yu, Z. Q. Yu, S. Zeissler, J. H. Zhang, M. T. Zhang, X. B. Zhang, Z. Zhang, Z. M. Zheng, H. L. Zhuang, V. Zhukov, A. Zichichi, N. Zimmermann, P. Zuccon, and C. Zurbach
Subjects: ASTROPHYSICS, Astrophysics and Astronomy, [SDU.ASTR.CO]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], Astrophysics::High Energy Astrophysical Phenomena, Positron spectrum, General Physics and Astronomy, Cosmic ray, Electron, ddc:500.2, Space mission, Nuclear physics, [PHYS.ASTR.CO]Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], Radiative flux, Physics and Astronomy (all), FIS/05 - ASTRONOMIA E ASTROFISICA, Positron, Alpha Magnetic Spectrometer, ddc:550, Dark matter, Positron emission, AMS, Cosmic rays, electron flux, positron flux, international space station, Cosmic rays, Physics, Spectral index, Range (particle radiation), ta115, POSITRONS, ELECTRONS, FIS/01 - FISICA SPERIMENTALE, High Energy Physics::Experiment, COSMIC RAYS, ELECTRONS, POSITRONS, AMS, Electron spectrum, Astroparticle physics, Astrophysics - High Energy Astrophysical Phenomena, Particle Physics - Experiment
Abstract: International audience; Precision measurements by the Alpha Magnetic Spectrometer on the International Space Station of the primary cosmic-ray electron flux in the range 0.5 to 700 GeV and the positron flux in the range 0.5 to500 GeV are presented. The electron flux and the positron flux each require a description beyond a single power-law spectrum. Both the electron flux and the positron flux change their behavior at∼30GeV but the fluxes are significantly different in their magnitude and energy dependence. Between 20 and 200 GeV the positron spectral index is significantly harder than the electron spectral index. The determination of the differing behavior of the spectral indices versus energy is a new observation and provides important information on the origins of cosmic-ray electrons and positrons.
Published: 2014

3. Properties of Cosmic Deuterons Measured by the Alpha Magnetic Spectrometer.

Author: Aguilar M, Alpat B, Ambrosi G, Anderson H, Arruda L, Attig N, Bagwell C, Barao F, Barbanera M, Barrin L, Bartoloni A, Battiston R, Bayyari A, Belyaev N, Bertucci B, Bindi V, Bollweg K, Bolster J, Borchiellini M, Borgia B, Boschini MJ, Bourquin M, Brugnoni C, Burger J, Burger WJ, Cai XD, Capell M, Casaus J, Castellini G, Cervelli F, Chang YH, Chen GM, Chen GR, Chen H, Chen HS, Chen Y, Cheng L, Chou HY, Chouridou S, Choutko V, Chung CH, Clark C, Coignet G, Consolandi C, Contin A, Corti C, Cui Z, Dadzie K, D'Angelo F, Dass A, Delgado C, Della Torre S, Demirköz MB, Derome L, Di Falco S, Di Felice V, Díaz C, Dimiccoli F, von Doetinchem P, Dong F, Donnini F, Duranti M, Egorov A, Eline A, Faldi F, Fehr D, Feng J, Fiandrini E, Fisher P, Formato V, Gámez C, García-López RJ, Gargiulo C, Gast H, Gervasi M, Giovacchini F, Gómez-Coral DM, Gong J, Grandi D, Graziani M, Guracho AN, Haino S, Han KC, Hashmani RK, He ZH, Heber B, Hsieh TH, Hu JY, Huang BW, Ionica M, Incagli M, Jia Y, Jinchi H, Karagöz G, Khan S, Khiali B, Kirn T, Klipfel AP, Kounina O, Kounine A, Koutsenko V, Krasnopevtsev D, Kuhlman A, Kulemzin A, La Vacca G, Laudi E, Laurenti G, LaVecchia G, Lazzizzera I, Lee HT, Lee SC, Li HL, Li JQ, Li M, Li M, Li Q, Li Q, Li QY, Li S, Li SL, Li JH, Li ZH, Liang MJ, Liao P, Lin CH, Lippert T, Liu JH, Liu PC, Lu SQ, Lu YS, Luebelsmeyer K, Luo JZ, Luo Q, Luo SD, Luo X, Mañá C, Marín J, Marquardt J, Martínez G, Masi N, Maurin D, Medvedeva T, Menchaca-Rocha A, Meng Q, Mikhailov VV, Molero M, Mott P, Mussolin L, Jozani YN, Nicolaidis R, Nikonov N, Nozzoli F, Ocampo-Peleteiro J, Oliva A, Orcinha M, Palmonari F, Paniccia M, Pashnin A, Pauluzzi M, Pensotti S, Pietzcker P, Plyaskin V, Poluianov S, Pridöhl D, Qu ZY, Quadrani L, Rancoita PG, Rapin D, Conde AR, Robyn E, Rodríguez-García I, Romaneehsen L, Rossi F, Rozhkov A, Rozza D, Sagdeev R, Savin E, Schael S, Schultz von Dratzig A, Schwering G, Seo ES, Shan BS, Shukla A, Siedenburg T, Silvestre G, Song JW, Song XJ, Sonnabend R, Strigari L, Su T, Sun Q, Sun ZT, Tabarroni L, Tacconi M, Tang ZC, Tian J, Tian Y, Ting SCC, Ting SM, Tomassetti N, Torsti J, Urban T, Usoskin I, Vagelli V, Vainio R, Valencia-Otero M, Valente E, Valtonen E, Vázquez Acosta M, Vecchi M, Velasco M, Wang CX, Wang L, Wang LQ, Wang NH, Wang QL, Wang S, Wang X, Wang ZM, Wei J, Weng ZL, Wu H, Wu Y, Wu ZB, Xiao JN, Xiong RQ, Xiong XZ, Xu W, Yan Q, Yang HT, Yang Y, Yelland A, Yi H, You YH, Yu YM, Yu ZQ, Zhang C, Zhang FZ, Zhang J, Zhang JH, Zhang Z, Zhao PW, Zheng C, Zheng ZM, Zhuang HL, Zhukov V, Zichichi A, and Zuccon P
Abstract: Precision measurements by the Alpha Magnetic Spectrometer (AMS) on the International Space Station of the deuteron (D) flux are presented. The measurements are based on 21×10^{6} D nuclei in the rigidity range from 1.9 to 21 GV collected from May 2011 to April 2021. We observe that over the entire rigidity range the D flux exhibits nearly identical time variations with the p, ^{3}He, and ^{4}He fluxes. Above 4.5 GV, the D/^{4}He flux ratio is time independent and its rigidity dependence is well described by a single power law ∝R^{Δ} with Δ_{D/^{4}He}=-0.108±0.005. This is in contrast with the ^{3}He/^{4}He flux ratio for which we find Δ_{^{3}He/^{4}He}=-0.289±0.003. Above ∼13 GV we find a nearly identical rigidity dependence of the D and p fluxes with a D/p flux ratio of 0.027±0.001. These unexpected observations indicate that cosmic deuterons have a sizable primarylike component. With a method independent of cosmic ray propagation, we obtain the primary component of the D flux equal to 9.4±0.5% of the ^{4}He flux and the secondary component of the D flux equal to 58±5% of the ^{3}He flux.
Published: 2024
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4. Temporal Structures in Positron Spectra and Charge-Sign Effects in Galactic Cosmic Rays.

Author: Aguilar M, Ambrosi G, Anderson H, Arruda L, Attig N, Bagwell C, Barao F, Barbanera M, Barrin L, Bartoloni A, Battiston R, Belyaev N, Berdugo J, Bertucci B, Bindi V, Bollweg K, Bolster J, Borchiellini M, Borgia B, Boschini MJ, Bourquin M, Burger J, Burger WJ, Cai XD, Capell M, Casaus J, Castellini G, Cervelli F, Chang YH, Chen GM, Chen GR, Chen H, Chen HS, Chen Y, Cheng L, Chou HY, Chouridou S, Choutko V, Chung CH, Clark C, Coignet G, Consolandi C, Contin A, Corti C, Cui Z, Dadzie K, D'Angelo F, Dass A, Delgado C, Della Torre S, Demirköz MB, Derome L, Di Falco S, Di Felice V, Díaz C, Dimiccoli F, von Doetinchem P, Dong F, Donnini F, Duranti M, Egorov A, Eline A, Faldi F, Feng J, Fiandrini E, Fisher P, Formato V, Gámez C, García-López RJ, Gargiulo C, Gast H, Gervasi M, Giovacchini F, Gómez-Coral DM, Gong J, Goy C, Grandi D, Graziani M, Guracho AN, Haino S, Han KC, Hashmani RK, He ZH, Heber B, Hsieh TH, Hu JY, Huang BW, Ionica M, Incagli M, Jia Y, Jinchi H, Karagöz G, Khan S, Khiali B, Kirn T, Klipfel AP, Kounina O, Kounine A, Koutsenko V, Krasnopevtsev D, Kuhlman A, Kulemzin A, La Vacca G, Laudi E, Laurenti G, LaVecchia G, Lazzizzera I, Lee HT, Lee SC, Li HL, Li JQ, Li M, Li M, Li Q, Li Q, Li QY, Li S, Li SL, Li JH, Li ZH, Liang J, Liang MJ, Lin CH, Lippert T, Liu JH, Lu SQ, Lu YS, Luebelsmeyer K, Luo JZ, Luo SD, Luo X, Mañá C, Marín J, Marquardt J, Martin T, Martínez G, Masi N, Maurin D, Medvedeva T, Menchaca-Rocha A, Meng Q, Molero M, Mott P, Mussolin L, Jozani YN, Negrete J, Nicolaidis R, Nikonov N, Nozzoli F, Ocampo-Peleteiro J, Oliva A, Orcinha M, Ottupara MA, Palermo M, Palmonari F, Paniccia M, Pashnin A, Pauluzzi M, Pensotti S, Plyaskin V, Poluianov S, Qin X, Qu ZY, Quadrani L, Rancoita PG, Rapin D, Conde AR, Robyn E, Rodríguez-García I, Romaneehsen L, Rossi F, Rozhkov A, Rozza D, Sagdeev R, Savin E, Schael S, von Dratzig AS, Schwering G, Seo ES, Shan BS, Siedenburg T, Silvestre G, Song JW, Song XJ, Sonnabend R, Strigari L, Su T, Sun Q, Sun ZT, Tacconi M, Tang XW, Tang ZC, Tian J, Tian Y, Ting SCC, Ting SM, Tomassetti N, Torsti J, Urban T, Usoskin I, Vagelli V, Vainio R, Valencia-Otero M, Valente E, Valtonen E, Vázquez Acosta M, Vecchi M, Velasco M, Vialle JP, Wang CX, Wang L, Wang LQ, Wang NH, Wang QL, Wang S, Wang X, Wang Y, Wang ZM, Wei J, Weng ZL, Wu H, Wu Y, Xiao JN, Xiong RQ, Xiong XZ, Xu W, Yan Q, Yang HT, Yang Y, Yelland A, Yi H, You YH, Yu YM, Yu ZQ, Zhang C, Zhang F, Zhang FZ, Zhang J, Zhang JH, Zhang Z, Zhao F, Zheng C, Zheng ZM, Zhuang HL, Zhukov V, Zichichi A, and Zuccon P
Abstract: We present the precision measurements of 11 years of daily cosmic positron fluxes in the rigidity range from 1.00 to 41.9 GV based on 3.4×10^{6} positrons collected with the Alpha Magnetic Spectrometer (AMS) aboard the International Space Station. The positron fluxes show distinctly different time variations from the electron fluxes at short and long timescales. A hysteresis between the electron fluxes and the positron fluxes is observed with a significance greater than 5σ at rigidities below 8.5 GV. On the contrary, the positron fluxes and the proton fluxes show similar time variation. Remarkably, we found that positron fluxes are modulated more than proton fluxes with a significance greater than 5σ for rigidities below 7 GV. These continuous daily positron fluxes, together with AMS daily electron, proton, and helium fluxes over an 11-year solar cycle, provide unique input to the understanding of both the charge-sign and mass dependencies of cosmic rays in the heliosphere.
Published: 2023
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5. Properties of Cosmic-Ray Sulfur and Determination of the Composition of Primary Cosmic-Ray Carbon, Neon, Magnesium, and Sulfur: Ten-Year Results from the Alpha Magnetic Spectrometer.

Author: Aguilar M, Ali Cavasonza L, Alpat B, Ambrosi G, Arruda L, Attig N, Bagwell C, Barao F, Barrin L, Bartoloni A, Başeğmez-du Pree S, Battiston R, Belyaev N, Berdugo J, Bertucci B, Bindi V, Bollweg K, Bolster J, Borchiellini M, Borgia B, Boschini MJ, Bourquin M, Bueno EF, Burger J, Burger WJ, Cai XD, Capell M, Casaus J, Castellini G, Cervelli F, Chang YH, Chen GM, Chen GR, Chen H, Chen HS, Chen Y, Cheng L, Chou HY, Chouridou S, Choutko V, Chung CH, Clark C, Coignet G, Consolandi C, Contin A, Corti C, Cui Z, Dadzie K, Dass A, Delgado C, Della Torre S, Demirköz MB, Derome L, Di Falco S, Di Felice V, Díaz C, Dimiccoli F, von Doetinchem P, Dong F, Donnini F, Duranti M, Egorov A, Eline A, Faldi F, Feng J, Fiandrini E, Fisher P, Formato V, Gámez C, García-López RJ, Gargiulo C, Gast H, Gervasi M, Giovacchini F, Gómez-Coral DM, Gong J, Goy C, Grabski V, Grandi D, Graziani M, Guracho AN, Haino S, Han KC, Hashmani RK, He ZH, Heber B, Hsieh TH, Hu JY, Huang BW, Incagli M, Jang WY, Jia Y, Jinchi H, Karagöz G, Khiali B, Kim GN, Kirn T, Kounina O, Kounine A, Koutsenko V, Krasnopevtsev D, Kuhlman A, Kulemzin A, La Vacca G, Laudi E, Laurenti G, LaVecchia G, Lazzizzera I, Lee HT, Lee SC, Li HL, Li JQ, Li M, Li M, Li Q, Li Q, Li QY, Li S, Li SL, Li JH, Li ZH, Liang J, Liang MJ, Lin CH, Lippert T, Liu JH, Lu SQ, Lu YS, Luebelsmeyer K, Luo JZ, Luo SD, Luo X, Machate F, Mañá C, Marín J, Marquardt J, Martin T, Martínez G, Masi N, Maurin D, Medvedeva T, Menchaca-Rocha A, Meng Q, Mikhailov VV, Molero M, Mott P, Mussolin L, Negrete J, Nikonov N, Nozzoli F, Ocampo-Peleteiro J, Oliva A, Orcinha M, Ottupara MA, Palermo M, Palmonari F, Paniccia M, Pashnin A, Pauluzzi M, Pensotti S, Plyaskin V, Poluianov S, Qin X, Qu ZY, Quadrani L, Rancoita PG, Rapin D, Reina Conde A, Robyn E, Romaneehsen L, Rozhkov A, Rozza D, Sagdeev R, Schael S, Schultz von Dratzig A, Schwering G, Seo ES, Shan BS, Siedenburg T, Song JW, Song XJ, Sonnabend R, Strigari L, Su T, Sun Q, Sun ZT, Tacconi M, Tang XW, Tang ZC, Tian J, Tian Y, Ting SCC, Ting SM, Tomassetti N, Torsti J, Urban T, Usoskin I, Vagelli V, Vainio R, Valencia-Otero M, Valente E, Valtonen E, Vázquez Acosta M, Vecchi M, Velasco M, Vialle JP, Wang CX, Wang L, Wang LQ, Wang NH, Wang QL, Wang S, Wang X, Wang Y, Wang ZM, Wei J, Weng ZL, Wu H, Wu Y, Xiao JN, Xiong RQ, Xiong XZ, Xu W, Yan Q, Yang HT, Yang Y, Yashin II, Yelland A, Yi H, You YH, Yu YM, Yu ZQ, Zannoni M, Zhang C, Zhang F, Zhang FZ, Zhang J, Zhang JH, Zhang Z, Zhao F, Zheng C, Zheng ZM, Zhuang HL, Zhukov V, Zichichi A, and Zuccon P
Subjects: Neon, Sulfur, Magnetic Phenomena, Magnesium, Carbon
Abstract: We report the properties of primary cosmic-ray sulfur (S) in the rigidity range 2.15 GV to 3.0 TV based on 0.38×10^{6} sulfur nuclei collected by the Alpha Magnetic Spectrometer experiment (AMS). We observed that above 90 GV the rigidity dependence of the S flux is identical to the rigidity dependence of Ne-Mg-Si fluxes, which is different from the rigidity dependence of the He-C-O-Fe fluxes. We found that, similar to N, Na, and Al cosmic rays, over the entire rigidity range, the traditional primary cosmic rays S, Ne, Mg, and C all have sizeable secondary components, and the S, Ne, and Mg fluxes are well described by the weighted sum of the primary silicon flux and the secondary fluorine flux, and the C flux is well described by the weighted sum of the primary oxygen flux and the secondary boron flux. The primary and secondary contributions of the traditional primary cosmic-ray fluxes of C, Ne, Mg, and S (even Z elements) are distinctly different from the primary and secondary contributions of the N, Na, and Al (odd Z elements) fluxes. The abundance ratio at the source for S/Si is 0.167±0.006, for Ne/Si is 0.833±0.025, for Mg/Si is 0.994±0.029, and for C/O is 0.836±0.025. These values are determined independent of cosmic-ray propagation.
Published: 2023
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6. Temporal Structures in Electron Spectra and Charge Sign Effects in Galactic Cosmic Rays.

Author: Aguilar M, Cavasonza LA, Ambrosi G, Arruda L, Attig N, Bagwell C, Barao F, Barrin L, Bartoloni A, Başeğmez-du Pree S, Battiston R, Behlmann M, Belyaev N, Berdugo J, Bertucci B, Bindi V, Bollweg K, Bolster J, Borgia B, Boschini MJ, Bourquin M, Bueno EF, Burger J, Burger WJ, Burmeister S, Cai XD, Capell M, Casaus J, Castellini G, Cervelli F, Chang YH, Chen GM, Chen GR, Chen HS, Chen Y, Cheng L, Chou HY, Chouridou S, Choutko V, Chung CH, Clark C, Coignet G, Consolandi C, Contin A, Corti C, Cui Z, Dadzie K, Dass A, Delgado C, Della Torre S, Demirköz MB, Derome L, Di Falco S, Di Felice V, Díaz C, Dimiccoli F, von Doetinchem P, Dong F, Donnini F, Duranti M, Egorov A, Eline A, Faldi F, Feng J, Fiandrini E, Fisher P, Formato V, Freeman C, Gámez C, García-López RJ, Gargiulo C, Gast H, Gervasi M, Giovacchini F, Gómez-Coral DM, Gong J, Goy C, Grabski V, Grandi D, Graziani M, Guracho AN, Haino S, Han KC, Hashmani RK, He ZH, Heber B, Hsieh TH, Hu JY, Incagli M, Jang WY, Jia Y, Jinchi H, Karagöz G, Khiali B, Kim GN, Kirn T, Kounina O, Kounine A, Koutsenko V, Krasnopevtsev D, Kuhlman A, Kulemzin A, La Vacca G, Laudi E, Laurenti G, LaVecchia G, Lazzizzera I, Lee HT, Lee SC, Li HL, Li JQ, Li M, Li Q, Li QY, Li S, Li SL, Li JH, Li ZH, Liang J, Liang MJ, Light C, Lin CH, Lippert T, Liu JH, Lu SQ, Lu YS, Luebelsmeyer K, Luo JZ, Luo X, Machate F, Mañá C, Marín J, Marquardt J, Martin T, Martínez G, Masi N, Maurin D, Medvedeva T, Menchaca-Rocha A, Meng Q, Mikhailov VV, Molero M, Mott P, Mussolin L, Negrete J, Nikonov N, Nozzoli F, Ocampo-Peleteiro J, Oliva A, Orcinha M, Palermo M, Palmonari F, Paniccia M, Pashnin A, Pauluzzi M, Pensotti S, Plyaskin V, Pohl M, Poluianov S, Qin X, Qu ZY, Quadrani L, Rancoita PG, Rapin D, Conde AR, Robyn E, Rosier-Lees S, Rozhkov A, Rozza D, Sagdeev R, Schael S, von Dratzig AS, Schwering G, Seo ES, Shan BS, Siedenburg T, Song JW, Song XJ, Sonnabend R, Strigari L, Su T, Sun Q, Sun ZT, Tacconi M, Tang XW, Tang ZC, Tian J, Ting SCC, Ting SM, Tomassetti N, Torsti J, Urban T, Usoskin I, Vagelli V, Vainio R, Valencia-Otero M, Valente E, Valtonen E, Vázquez Acosta M, Vecchi M, Velasco M, Vialle JP, Wang CX, Wang L, Wang LQ, Wang NH, Wang QL, Wang S, Wang X, Wang Y, Wang ZM, Wei J, Weng ZL, Wu H, Xiong RQ, Xu W, Yan Q, Yang Y, Yashin II, Yelland A, Yi H, Yu YM, Yu ZQ, Zannoni M, Zhang C, Zhang F, Zhang FZ, Zhang JH, Zhang Z, Zhao F, Zheng C, Zheng ZM, Zhuang HL, Zhukov V, Zichichi A, and Zuccon P
Abstract: We present the precision measurements of 11 years of daily cosmic electron fluxes in the rigidity interval from 1.00 to 41.9 GV based on 2.0×10^{8} electrons collected with the Alpha Magnetic Spectrometer (AMS) aboard the International Space Station. The electron fluxes exhibit variations on multiple timescales. Recurrent electron flux variations with periods of 27 days, 13.5 days, and 9 days are observed. We find that the electron fluxes show distinctly different time variations from the proton fluxes. Remarkably, a hysteresis between the electron flux and the proton flux is observed with a significance of greater than 6σ at rigidities below 8.5 GV. Furthermore, significant structures in the electron-proton hysteresis are observed corresponding to sharp structures in both fluxes. This continuous daily electron data provide unique input to the understanding of the charge sign dependence of cosmic rays over an 11-year solar cycle.
Published: 2023
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7. Enzyme-Responsive Double-Locked Photodynamic Molecular Beacon for Targeted Photodynamic Anticancer Therapy.

Author: Tam LKB, Chu JCH, He L, Yang C, Han KC, Cheung PCK, Ng DKP, and Lo PC
Subjects: Mice, Animals, Matrix Metalloproteinase 2, Cathepsin B, Mice, Nude, Cell Line, Tumor, Photosensitizing Agents pharmacology, Photosensitizing Agents therapeutic use, Photosensitizing Agents chemistry, Peptides chemistry, Photochemotherapy
Abstract: An advanced photodynamic molecular beacon (PMB) was designed and synthesized, in which a distyryl boron dipyrromethene (DSBDP)-based photosensitizer and a Black Hole Quencher 3 moiety were connected via two peptide segments containing the sequences PLGVR and GFLG, respectively, of a cyclic peptide. These two short peptide sequences are well-known substrates of matrix metalloproteinase-2 (MMP-2) and cathepsin B, respectively, both of which are overexpressed in a wide range of cancer cells either extracellularly (for MMP-2) or intracellularly (for cathepsin B). Owing to the efficient Förster resonance energy transfer between the two components, this PMB was fully quenched in the native form. Only upon interaction with both MMP-2 and cathepsin B, either in a buffer solution or in cancer cells, both of the segments were cleaved specifically, and the two components could be completely separated, thereby restoring the photodynamic activities of the DSBDP moiety. This PMB could also be activated in tumors, and it effectively suppressed the tumor growth in A549 tumor-bearing nude mice upon laser irradiation without causing notable side effects. In particular, it did not cause skin photosensitivity, which is a very common side effect of photodynamic therapy (PDT) using conventional "always-on" photosensitizers. The overall results showed that this "double-locked" PMB functioned as a biological AND logic gate that could only be unlocked by the coexistence of two tumor-associated enzymes, which could greatly enhance the tumor specificity in PDT.
Published: 2023
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8. A ring-like accretion structure in M87 connecting its black hole and jet.

Author: Lu RS, Asada K, Krichbaum TP, Park J, Tazaki F, Pu HY, Nakamura M, Lobanov A, Hada K, Akiyama K, Kim JY, Marti-Vidal I, Gómez JL, Kawashima T, Yuan F, Ros E, Alef W, Britzen S, Bremer M, Broderick AE, Doi A, Giovannini G, Giroletti M, Ho PTP, Honma M, Hughes DH, Inoue M, Jiang W, Kino M, Koyama S, Lindqvist M, Liu J, Marscher AP, Matsushita S, Nagai H, Rottmann H, Savolainen T, Schuster KF, Shen ZQ, de Vicente P, Walker RC, Yang H, Zensus JA, Algaba JC, Allardi A, Bach U, Berthold R, Bintley D, Byun DY, Casadio C, Chang SH, Chang CC, Chang SC, Chen CC, Chen MT, Chilson R, Chuter TC, Conway J, Crew GB, Dempsey JT, Dornbusch S, Faber A, Friberg P, García JG, Garrido MG, Han CC, Han KC, Hasegawa Y, Herrero-Illana R, Huang YD, Huang CL, Impellizzeri V, Jiang H, Jinchi H, Jung T, Kallunki J, Kirves P, Kimura K, Koay JY, Koch PM, Kramer C, Kraus A, Kubo D, Kuo CY, Li CT, Lin LC, Liu CT, Liu KY, Lo WP, Lu LM, MacDonald N, Martin-Cocher P, Messias H, Meyer-Zhao Z, Minter A, Nair DG, Nishioka H, Norton TJ, Nystrom G, Ogawa H, Oshiro P, Patel NA, Pen UL, Pidopryhora Y, Pradel N, Raffin PA, Rao R, Ruiz I, Sanchez S, Shaw P, Snow W, Sridharan TK, Srinivasan R, Tercero B, Torne P, Traianou E, Wagner J, Walther C, Wei TS, Yang J, and Yu CY
Abstract: The nearby radio galaxy M87 is a prime target for studying black hole accretion and jet formation 1,2 . Event Horizon Telescope observations of M87 in 2017, at a wavelength of 1.3 mm, revealed a ring-like structure, which was interpreted as gravitationally lensed emission around a central black hole 3 . Here we report images of M87 obtained in 2018, at a wavelength of 3.5 mm, showing that the compact radio core is spatially resolved. High-resolution imaging shows a ring-like structure of [Formula: see text] Schwarzschild radii in diameter, approximately 50% larger than that seen at 1.3 mm. The outer edge at 3.5 mm is also larger than that at 1.3 mm. This larger and thicker ring indicates a substantial contribution from the accretion flow with absorption effects, in addition to the gravitationally lensed ring-like emission. The images show that the edge-brightened jet connects to the accretion flow of the black hole. Close to the black hole, the emission profile of the jet-launching region is wider than the expected profile of a black-hole-driven jet, suggesting the possible presence of a wind associated with the accretion flow., (© 2023. The Author(s).)
Published: 2023
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9. Properties of Daily Helium Fluxes.

Author: Aguilar M, Cavasonza LA, Ambrosi G, Arruda L, Attig N, Barao F, Barrin L, Bartoloni A, Başeğmez-du Pree S, Battiston R, Behlmann M, Berdugo J, Bertucci B, Bindi V, Bollweg K, Borgia B, Boschini MJ, Bourquin M, Bueno EF, Burger J, Burger WJ, Burmeister S, Cai XD, Capell M, Casaus J, Castellini G, Cervelli F, Chang YH, Chen GM, Chen GR, Chen HS, Chen Y, Cheng L, Chou HY, Chouridou S, Choutko V, Chung CH, Clark C, Coignet G, Consolandi C, Contin A, Corti C, Cui Z, Dadzie K, Dass A, Delgado C, Della Torre S, Demirköz MB, Derome L, Di Falco S, Di Felice V, Díaz C, Dimiccoli F, von Doetinchem P, Dong F, Donnini F, Duranti M, Egorov A, Eline A, Feng J, Fiandrini E, Fisher P, Formato V, Freeman C, Gámez C, García-López RJ, Gargiulo C, Gast H, Gervasi M, Giovacchini F, Gómez-Coral DM, Gong J, Goy C, Grabski V, Grandi D, Graziani M, Haino S, Han KC, Hashmani RK, He ZH, Heber B, Hsieh TH, Hu JY, Incagli M, Jang WY, Jia Y, Jinchi H, Karagöz G, Khiali B, Kim GN, Kirn T, Konyushikhin M, Kounina O, Kounine A, Koutsenko V, Krasnopevtsev D, Kuhlman A, Kulemzin A, La Vacca G, Laudi E, Laurenti G, Lazzizzera I, Lee HT, Lee SC, Li HL, Li JQ, Li M, Li Q, Li QY, Li S, Li SL, Li JH, Li ZH, Liang J, Liang MJ, Light C, Lin CH, Lippert T, Liu JH, Lu SQ, Lu YS, Luebelsmeyer K, Luo JZ, Luo X, Machate F, Mañá C, Marín J, Marquardt J, Martin T, Martínez G, Masi N, Maurin D, Medvedeva T, Menchaca-Rocha A, Meng Q, Mikhailov VV, Molero M, Mott P, Mussolin L, Negrete J, Nikonov N, Nozzoli F, Ocampo-Peleteiro J, Oliva A, Orcinha M, Palermo M, Palmonari F, Paniccia M, Pashnin A, Pauluzzi M, Pensotti S, Plyaskin V, Pohl M, Poluianov S, Qin X, Qu ZY, Quadrani L, Rancoita PG, Rapin D, Conde AR, Robyn E, Rosier-Lees S, Rozhkov A, Rozza D, Sagdeev R, Schael S, von Dratzig AS, Schwering G, Seo ES, Shan BS, Siedenburg T, Song JW, Song XJ, Sonnabend R, Strigari L, Su T, Sun Q, Sun ZT, Tacconi M, Tang XW, Tang ZC, Tian J, Ting SCC, Ting SM, Tomassetti N, Torsti J, Urban T, Usoskin I, Vagelli V, Vainio R, Valencia-Otero M, Valente E, Valtonen E, Vázquez Acosta M, Vecchi M, Velasco M, Vialle JP, Wang CX, Wang L, Wang LQ, Wang NH, Wang QL, Wang S, Wang X, Wang Y, Wang ZM, Wei J, Weng ZL, Wu H, Xiong RQ, Xu W, Yan Q, Yang Y, Yashin II, Yi H, Yu YM, Yu ZQ, Zannoni M, Zhang C, Zhang F, Zhang FZ, Zhang JH, Zhang Z, Zhao F, Zheng C, Zheng ZM, Zhuang HL, Zhukov V, Zichichi A, and Zuccon P
Abstract: We present the precision measurement of 2824 daily helium fluxes in cosmic rays from May 20, 2011 to October 29, 2019 in the rigidity interval from 1.71 to 100 GV based on 7.6×10^{8} helium nuclei collected with the Alpha Magnetic Spectrometer (AMS) aboard the International Space Station. The helium flux and the helium to proton flux ratio exhibit variations on multiple timescales. In nearly all the time intervals from 2014 to 2018, we observed recurrent helium flux variations with a period of 27 days. Shorter periods of 9 days and 13.5 days are observed in 2016. The strength of all three periodicities changes with time and rigidity. In the entire time period, we found that below ∼7 GV the helium flux exhibits larger time variations than the proton flux, and above ∼7 GV the helium to proton flux ratio is time independent. Remarkably, below 2.4 GV a hysteresis between the helium to proton flux ratio and the helium flux was observed at greater than the 7σ level. This shows that at low rigidity the modulation of the helium to proton flux ratio is different before and after the solar maximum in 2014.
Published: 2022
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10. Facile discovery of a therapeutic agent for NK-mediated synergistic antitumor effects using a patient-derived 3D platform.

Author: Lee YE, Yuk CM, Lee M, Han KC, Jun E, Kim TS, Ku JL, Im SG, Lee E, and Jang M
Subjects: Cell Line, Tumor, Coculture Techniques, Humans, Immunotherapy, Killer Cells, Natural, Neoplasms drug therapy, Tumor Microenvironment
Abstract: Despite the essential roles of natural killer (NK) cells in cancer treatment, the physical barrier and biological cues of the tumor microenvironment (TME) may induce NK cell dysfunction, causing their poor infiltration into tumors. The currently available two-dimensional (2D) cancer-NK co-culture systems hardly represent the characteristics of TME and are not suitable for tracking the infiltration of immune cells and assessing the efficacy of immunotherapy. This study aims to monitor NK-mediated cancer cell killing using a polymer thin film-based, 3D assay platform that contains highly tumorigenic cancer spheroids. A poly(cyclohexyl methacrylate) (pCHMA)-coated surface enables the generation of tumorigenic spheroids from pancreatic cancer patient-derived cancer cells, showing considerable amounts of extracellular matrix (ECM) proteins and cancer stem cell (CSC)-like characteristics. The 3D spheroid-based assay platform allows rapid discovery of a therapeutic agent for synergistic NK-mediated cytotoxicity through imaging-based high-content screening. In detail, the small molecule C19, known as a multi-epithelial-mesenchymal transition pathway inhibitor, is shown to enhance NK activation and infiltration via modulation of the ECM, resulting in synergistic cytotoxicity against cancer spheroids. This 3D biomimetic co-culture assay platform provides promising applications for predicting patient-specific responses to immunotherapy through advanced therapeutic combinations involving a chemical drug and immune cells.
Published: 2022
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11. Periodicities in the Daily Proton Fluxes from 2011 to 2019 Measured by the Alpha Magnetic Spectrometer on the International Space Station from 1 to 100 GV.

Author: Aguilar M, Cavasonza LA, Ambrosi G, Arruda L, Attig N, Barao F, Barrin L, Bartoloni A, Başeğmez-du Pree S, Battiston R, Behlmann M, Beranek B, Berdugo J, Bertucci B, Bindi V, Bollweg K, Borgia B, Boschini MJ, Bourquin M, Bueno EF, Burger J, Burger WJ, Burmeister S, Cai XD, Capell M, Casaus J, Castellini G, Cervelli F, Chang YH, Chen GM, Chen GR, Chen HS, Chen Y, Cheng L, Chou HY, Chouridou S, Choutko V, Chung CH, Clark C, Coignet G, Consolandi C, Contin A, Corti C, Cui Z, Dadzie K, Dass A, Delgado C, Della Torre S, Demirköz MB, Derome L, Di Falco S, Di Felice V, Díaz C, Dimiccoli F, von Doetinchem P, Dong F, Donnini F, Duranti M, Egorov A, Eline A, Feng J, Fiandrini E, Fisher P, Formato V, Freeman C, Gámez C, García-López RJ, Gargiulo C, Gast H, Gervasi M, Giovacchini F, Gómez-Coral DM, Gong J, Goy C, Grabski V, Grandi D, Graziani M, Haino S, Han KC, Hashmani RK, He ZH, Heber B, Hsieh TH, Hu JY, Incagli M, Jang WY, Jia Y, Jinchi H, Karagöz G, Khiali B, Kim GN, Kirn T, Konyushikhin M, Kounina O, Kounine A, Koutsenko V, Krasnopevtsev D, Kuhlman A, Kulemzin A, La Vacca G, Laudi E, Laurenti G, Lazzizzera I, Lebedev A, Lee HT, Lee SC, Li JQ, Li M, Li Q, Li S, Li JH, Li ZH, Liang J, Light C, Lin CH, Lippert T, Liu JH, Liu Z, Lu SQ, Lu YS, Luebelsmeyer K, Luo JZ, Luo X, Machate F, Mañá C, Marín J, Marquardt J, Martin T, Martínez G, Masi N, Maurin D, Medvedeva T, Menchaca-Rocha A, Meng Q, Mikhailov VV, Molero M, Mott P, Mussolin L, Negrete J, Nikonov N, Nozzoli F, Oliva A, Orcinha M, Palermo M, Palmonari F, Paniccia M, Pashnin A, Pauluzzi M, Pensotti S, Phan HD, Plyaskin V, Pohl M, Poluianov S, Qin X, Qu ZY, Quadrani L, Rancoita PG, Rapin D, Conde AR, Robyn E, Rosier-Lees S, Rozhkov A, Rozza D, Sagdeev R, Schael S, von Dratzig AS, Schwering G, Seo ES, Shakfa Z, Shan BS, Siedenburg T, Solano C, Song JW, Song XJ, Sonnabend R, Strigari L, Su T, Sun Q, Sun ZT, Tacconi M, Tang XW, Tang ZC, Tian J, Ting SCC, Ting SM, Tomassetti N, Torsti J, Urban T, Usoskin I, Vagelli V, Vainio R, Valencia-Otero M, Valente E, Valtonen E, Vázquez Acosta M, Vecchi M, Velasco M, Vialle JP, Wang CX, Wang L, Wang LQ, Wang NH, Wang QL, Wang S, Wang X, Wang Y, Wang ZM, Wei J, Weng ZL, Wu H, Xiong RQ, Xu W, Yan Q, Yang Y, Yashin II, Yi H, Yu YM, Yu ZQ, Zannoni M, Zhang C, Zhang F, Zhang FZ, Zhang JH, Zhang Z, Zhao F, Zheng C, Zheng ZM, Zhuang HL, Zhukov V, Zichichi A, and Zuccon P
Abstract: We present the precision measurement of the daily proton fluxes in cosmic rays from May 20, 2011 to October 29, 2019 (a total of 2824 days or 114 Bartels rotations) in the rigidity interval from 1 to 100 GV based on 5.5×10^{9} protons collected with the Alpha Magnetic Spectrometer aboard the International Space Station. The proton fluxes exhibit variations on multiple timescales. From 2014 to 2018, we observed recurrent flux variations with a period of 27 days. Shorter periods of 9 days and 13.5 days are observed in 2016. The strength of all three periodicities changes with time and rigidity. The rigidity dependence of the 27-day periodicity is different from the rigidity dependences of 9-day and 13.5-day periods. Unexpectedly, the strength of 9-day and 13.5-day periodicities increases with increasing rigidities up to ∼10 GV and ∼20 GV, respectively. Then the strength of the periodicities decreases with increasing rigidity up to 100 GV.
Published: 2021
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12. Erratum: Properties of a New Group of Cosmic Nuclei: Results from the Alpha Magnetic Spectrometer on Sodium, Aluminum, and Nitrogen [Phys. Rev. Lett. 127, 021101 (2021)].

Author: Aguilar M, Cavasonza LA, Alpat B, Ambrosi G, Arruda L, Attig N, Barao F, Barrin L, Bartoloni A, Başeğmez-du Pree S, Battiston R, Behlmann M, Beranek B, Berdugo J, Bertucci B, Bindi V, Bollweg K, Borgia B, Boschini MJ, Bourquin M, Bueno EF, Burger J, Burger WJ, Burmeister S, Cai XD, Capell M, Casaus J, Castellini G, Cervelli F, Chang YH, Chen GM, Chen GR, Chen HS, Chen Y, Cheng L, Chou HY, Chouridou S, Choutko V, Chung CH, Clark C, Coignet G, Consolandi C, Contin A, Corti C, Cui Z, Dadzie K, Delgado C, Della Torre S, Demirköz MB, Derome L, Di Falco S, Di Felice V, Díaz C, Dimiccoli F, von Doetinchem P, Dong F, Donnini F, Duranti M, Egorov A, Eline A, Feng J, Fiandrini E, Fisher P, Formato V, Freeman C, Gámez C, García-López RJ, Gargiulo C, Gast H, Gervasi M, Giovacchini F, Gómez-Coral DM, Gong J, Goy C, Grabski V, Grandi D, Graziani M, Haino S, Han KC, Hashmani RK, He ZH, Heber B, Hsieh TH, Hu JY, Incagli M, Jang WY, Jia Y, Jinchi H, Khiali B, Kim GN, Kirn T, Konyushikhin M, Kounina O, Kounine A, Koutsenko V, Krasnopevtsev D, Kuhlman A, Kulemzin A, La Vacca G, Laudi E, Laurenti G, Lazzizzera I, Lebedev A, Lee HT, Lee SC, Li JQ, Li M, Li Q, Li S, Li JH, Li ZH, Liang J, Light C, Lin CH, Lippert T, Liu JH, Liu Z, Lu SQ, Lu YS, Luebelsmeyer K, Luo JZ, Luo X, Machate F, Mañá C, Marín J, Marquardt J, Martin T, Martínez G, Masi N, Maurin D, Medvedeva T, Menchaca-Rocha A, Meng Q, Mikhailov VV, Molero M, Mott P, Mussolin L, Negrete J, Nikonov N, Nozzoli F, Oliva A, Orcinha M, Palermo M, Palmonari F, Paniccia M, Pashnin A, Pauluzzi M, Pensotti S, Phan HD, Plyaskin V, Pohl M, Poluianov S, Qin X, Qu ZY, Quadrani L, Rancoita PG, Rapin D, Conde AR, Robyn E, Rosier-Lees S, Rozhkov A, Rozza D, Sagdeev R, Schael S, von Dratzig AS, Schwering G, Seo ES, Shakfa Z, Shan BS, Siedenburg T, Solano C, Song JW, Song XJ, Sonnabend R, Strigari L, Su T, Sun Q, Sun ZT, Tacconi M, Tang XW, Tang ZC, Tian J, Ting SCC, Ting SM, Tomassetti N, Torsti J, Tüysüz C, Urban T, Usoskin I, Vagelli V, Vainio R, Valencia-Otero M, Valente E, Valtonen E, Vázquez Acosta M, Vecchi M, Velasco M, Vialle JP, Wang CX, Wang L, Wang LQ, Wang NH, Wang QL, Wang S, Wang X, Wang Y, Wang ZM, Wei J, Weng ZL, Wu H, Xiong RQ, Xu W, Yan Q, Yang Y, Yashin II, Yi H, Yu YM, Yu ZQ, Zannoni M, Zhang C, Zhang F, Zhang FZ, Zhang JH, Zhang Z, Zhao F, Zheng C, Zheng ZM, Zhuang HL, Zhukov V, Zichichi A, and Zuccon P
Abstract: This corrects the article DOI: 10.1103/PhysRevLett.127.021101.
Published: 2021
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13. Properties of a New Group of Cosmic Nuclei: Results from the Alpha Magnetic Spectrometer on Sodium, Aluminum, and Nitrogen.

Author: Aguilar M, Cavasonza LA, Alpat B, Ambrosi G, Arruda L, Attig N, Barao F, Barrin L, Bartoloni A, Başeğmez-du Pree S, Battiston R, Behlmann M, Beranek B, Berdugo J, Bertucci B, Bindi V, Bollweg K, Borgia B, Boschini MJ, Bourquin M, Bueno EF, Burger J, Burger WJ, Burmeister S, Cai XD, Capell M, Casaus J, Castellini G, Cervelli F, Chang YH, Chen GM, Chen GR, Chen HS, Chen Y, Cheng L, Chou HY, Chouridou S, Choutko V, Chung CH, Clark C, Coignet G, Consolandi C, Contin A, Corti C, Cui Z, Dadzie K, Delgado C, Della Torre S, Demirköz MB, Derome L, Di Falco S, Di Felice V, Díaz C, Dimiccoli F, von Doetinchem P, Dong F, Donnini F, Duranti M, Egorov A, Eline A, Feng J, Fiandrini E, Fisher P, Formato V, Freeman C, Gámez C, García-López RJ, Gargiulo C, Gast H, Gervasi M, Giovacchini F, Gómez-Coral DM, Gong J, Goy C, Grabski V, Grandi D, Graziani M, Haino S, Han KC, Hashmani RK, He ZH, Heber B, Hsieh TH, Hu JY, Incagli M, Jang WY, Jia Y, Jinchi H, Khiali B, Kim GN, Kirn T, Konyushikhin M, Kounina O, Kounine A, Koutsenko V, Krasnopevtsev D, Kuhlman A, Kulemzin A, La Vacca G, Laudi E, Laurenti G, Lazzizzera I, Lebedev A, Lee HT, Lee SC, Li JQ, Li M, Li Q, Li S, Li JH, Li ZH, Liang J, Light C, Lin CH, Lippert T, Liu JH, Liu Z, Lu SQ, Lu YS, Luebelsmeyer K, Luo JZ, Luo X, Machate F, Mañá C, Marín J, Marquardt J, Martin T, Martínez G, Masi N, Maurin D, Medvedeva T, Menchaca-Rocha A, Meng Q, Mikhailov VV, Molero M, Mott P, Mussolin L, Negrete J, Nikonov N, Nozzoli F, Oliva A, Orcinha M, Palermo M, Palmonari F, Paniccia M, Pashnin A, Pauluzzi M, Pensotti S, Phan HD, Plyaskin V, Pohl M, Poluianov S, Qin X, Qu ZY, Quadrani L, Rancoita PG, Rapin D, Conde AR, Robyn E, Rosier-Lees S, Rozhkov A, Rozza D, Sagdeev R, Schael S, von Dratzig AS, Schwering G, Seo ES, Shakfa Z, Shan BS, Siedenburg T, Solano C, Song JW, Song XJ, Sonnabend R, Strigari L, Su T, Sun Q, Sun ZT, Tacconi M, Tang XW, Tang ZC, Tian J, Ting SCC, Ting SM, Tomassetti N, Torsti J, Tüysüz C, Urban T, Usoskin I, Vagelli V, Vainio R, Valencia-Otero M, Valente E, Valtonen E, Vázquez Acosta M, Vecchi M, Velasco M, Vialle JP, Wang CX, Wang L, Wang LQ, Wang NH, Wang QL, Wang S, Wang X, Wang Y, Wang ZM, Wei J, Weng ZL, Wu H, Xiong RQ, Xu W, Yan Q, Yang Y, Yashin II, Yi H, Yu YM, Yu ZQ, Zannoni M, Zhang C, Zhang F, Zhang FZ, Zhang JH, Zhang Z, Zhao F, Zheng C, Zheng ZM, Zhuang HL, Zhukov V, Zichichi A, and Zuccon P
Abstract: We report the properties of sodium (Na) and aluminum (Al) cosmic rays in the rigidity range 2.15 GV to 3.0 TV based on 0.46 million sodium and 0.51 million aluminum nuclei collected by the Alpha Magnetic Spectrometer experiment on the International Space Station. We found that Na and Al, together with nitrogen (N), belong to a distinct cosmic ray group. In this group, we observe that, similar to the N flux, both the Na flux and Al flux are well described by the sums of a primary cosmic ray component (proportional to the silicon flux) and a secondary cosmic ray component (proportional to the fluorine flux). The fraction of the primary component increases with rigidity for the N, Na, and Al fluxes and becomes dominant at the highest rigidities. The Na/Si and Al/Si abundance ratios at the source, 0.036±0.003 for Na/Si and 0.103±0.004 for Al/Si, are determined independent of cosmic ray propagation.
Published: 2021
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14. Properties of Heavy Secondary Fluorine Cosmic Rays: Results from the Alpha Magnetic Spectrometer.

Author: Aguilar M, Cavasonza LA, Allen MS, Alpat B, Ambrosi G, Arruda L, Attig N, Barao F, Barrin L, Bartoloni A, Başeğmez-du Pree S, Battiston R, Behlmann M, Beranek B, Berdugo J, Bertucci B, Bindi V, Bollweg K, Borgia B, Boschini MJ, Bourquin M, Bueno EF, Burger J, Burger WJ, Burmeister S, Cai XD, Capell M, Casaus J, Castellini G, Cervelli F, Chang YH, Chen GM, Chen GR, Chen HS, Chen Y, Cheng L, Chou HY, Chouridou S, Choutko V, Chung CH, Clark C, Coignet G, Consolandi C, Contin A, Corti C, Cui Z, Dadzie K, Delgado C, Della Torre S, Demirköz MB, Derome L, Di Falco S, Di Felice V, Díaz C, Dimiccoli F, von Doetinchem P, Dong F, Donnini F, Duranti M, Egorov A, Eline A, Feng J, Fiandrini E, Fisher P, Formato V, Freeman C, Galaktionov Y, Gámez C, García-López RJ, Gargiulo C, Gast H, Gervasi M, Giovacchini F, Gómez-Coral DM, Gong J, Goy C, Grabski V, Grandi D, Graziani M, Haino S, Han KC, Hashmani RK, He ZH, Heber B, Hsieh TH, Hu JY, Incagli M, Jang WY, Jia Y, Jinchi H, Kanishev K, Khiali B, Kim GN, Kirn T, Konyushikhin M, Kounina O, Kounine A, Koutsenko V, Kuhlman A, Kulemzin A, La Vacca G, Laudi E, Laurenti G, Lazzizzera I, Lebedev A, Lee HT, Lee SC, Li JQ, Li M, Li Q, Li S, Li JH, Li ZH, Liang J, Light C, Lin CH, Lippert T, Liu JH, Liu Z, Lu SQ, Lu YS, Luebelsmeyer K, Luo JZ, Luo X, Lyu SS, Machate F, Mañá C, Marín J, Marquardt J, Martin T, Martínez G, Masi N, Maurin D, Menchaca-Rocha A, Meng Q, Mikhailov VV, Mo DC, Molero M, Mott P, Mussolin L, Negrete J, Nikonov N, Nozzoli F, Oliva A, Orcinha M, Palermo M, Palmonari F, Paniccia M, Pashnin A, Pauluzzi M, Pensotti S, Phan HD, Piandani R, Plyaskin V, Poluianov S, Qin X, Qu ZY, Quadrani L, Rancoita PG, Rapin D, Conde AR, Robyn E, Rosier-Lees S, Rozhkov A, Rozza D, Sagdeev R, Schael S, Schulz von Dratzig A, Schwering G, Seo ES, Shakfa Z, Shan BS, Siedenburg T, Solano C, Song JW, Song XJ, Sonnabend R, Strigari L, Su T, Sun Q, Sun ZT, Tacconi M, Tang XW, Tang ZC, Tian J, Ting SCC, Ting SM, Tomassetti N, Torsti J, Tüysüz C, Urban T, Usoskin I, Vagelli V, Vainio R, Valencia-Otero M, Valente E, Valtonen E, Vázquez Acosta M, Vecchi M, Velasco M, Vialle JP, Wang CX, Wang L, Wang LQ, Wang NH, Wang QL, Wang S, Wang X, Wang Y, Wang ZM, Wei J, Weng ZL, Wu H, Xiong RQ, Xu W, Yan Q, Yang Y, Yashin II, Yi H, Yu YM, Yu ZQ, Zannoni M, Zhang C, Zhang F, Zhang FZ, Zhang JH, Zhang Z, Zhao F, Zheng C, Zheng ZM, Zhuang HL, Zhukov V, Zichichi A, and Zuccon P
Abstract: Precise knowledge of the charge and rigidity dependence of the secondary cosmic ray fluxes and the secondary-to-primary flux ratios is essential in the understanding of cosmic ray propagation. We report the properties of heavy secondary cosmic ray fluorine F in the rigidity R range 2.15 GV to 2.9 TV based on 0.29 million events collected by the Alpha Magnetic Spectrometer experiment on the International Space Station. The fluorine spectrum deviates from a single power law above 200 GV. The heavier secondary-to-primary F/Si flux ratio rigidity dependence is distinctly different from the lighter B/O (or B/C) rigidity dependence. In particular, above 10 GV, the F/Si/B/O ratio can be described by a power law R^{δ} with δ=0.052±0.007. This shows that the propagation properties of heavy cosmic rays, from F to Si, are different from those of light cosmic rays, from He to O, and that the secondary cosmic rays have two classes.
Published: 2021
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15. Properties of Iron Primary Cosmic Rays: Results from the Alpha Magnetic Spectrometer.

Author: Aguilar M, Cavasonza LA, Allen MS, Alpat B, Ambrosi G, Arruda L, Attig N, Barao F, Barrin L, Bartoloni A, Başeğmez-du Pree S, Battiston R, Behlmann M, Beischer B, Berdugo J, Bertucci B, Bindi V, de Boer W, Bollweg K, Borgia B, Boschini MJ, Bourquin M, Bueno EF, Burger J, Burger WJ, Burmeister S, Cai XD, Capell M, Casaus J, Castellini G, Cervelli F, Chang YH, Chen GM, Chen GR, Chen HS, Chen Y, Cheng L, Chou HY, Chouridou S, Choutko V, Chung CH, Clark C, Coignet G, Consolandi C, Contin A, Corti C, Cui Z, Dadzie K, Delgado C, Della Torre S, Demirköz MB, Derome L, Di Falco S, Di Felice V, Díaz C, Dimiccoli F, von Doetinchem P, Dong F, Donnini F, Duranti M, Egorov A, Eline A, Feng J, Fiandrini E, Fisher P, Formato V, Freeman C, Galaktionov Y, Gámez C, García-López RJ, Gargiulo C, Gast H, Gervasi M, Giovacchini F, Gómez-Coral DM, Gong J, Goy C, Grabski V, Grandi D, Graziani M, Haino S, Han KC, Hashmani RK, He ZH, Heber B, Hsieh TH, Hu JY, Incagli M, Jang WY, Jia Y, Jinchi H, Kanishev K, Khiali B, Kim GN, Kirn T, Konyushikhin M, Kounina O, Kounine A, Koutsenko V, Kuhlman A, Kulemzin A, La Vacca G, Laudi E, Laurenti G, Lazzizzera I, Lebedev A, Lee HT, Lee SC, Li JQ, Li M, Li Q, Li S, Li JH, Li ZH, Liang J, Light C, Lin CH, Lippert T, Liu JH, Liu Z, Lu SQ, Lu YS, Luebelsmeyer K, Luo JZ, Luo X, Lyu SS, Machate F, Mañá C, Marín J, Marquardt J, Martin T, Martínez G, Masi N, Maurin D, Menchaca-Rocha A, Meng Q, Mikhailov VV, Mo DC, Molero M, Mott P, Mussolin L, Negrete J, Nikonov N, Nozzoli F, Oliva A, Orcinha M, Palermo M, Palmonari F, Paniccia M, Pashnin A, Pauluzzi M, Pensotti S, Phan HD, Piandani R, Plyaskin V, Poluianov S, Qin X, Qu ZY, Quadrani L, Rancoita PG, Rapin D, Conde AR, Robyn E, Rosier-Lees S, Rozhkov A, Rozza D, Sagdeev R, Schael S, von Dratzig AS, Schwering G, Seo ES, Shakfa Z, Shan BS, Siedenburg T, Solano C, Song JW, Song XJ, Sonnabend R, Strigari L, Su T, Sun Q, Sun ZT, Tacconi M, Tang XW, Tang ZC, Tian J, Ting SCC, Ting SM, Tomassetti N, Torsti J, Tüysüz C, Urban T, Usoskin I, Vagelli V, Vainio R, Valencia-Otero M, Valente E, Valtonen E, Vázquez Acosta M, Vecchi M, Velasco M, Vialle JP, Wang CX, Wang L, Wang LQ, Wang NH, Wang QL, Wang S, Wang X, Wang Y, Wang ZM, Wei J, Weng ZL, Wu H, Xiong RQ, Xu W, Yan Q, Yang Y, Yashin II, Yi H, Yu YM, Yu ZQ, Zannoni M, Zhang C, Zhang F, Zhang FZ, Zhang JH, Zhang Z, Zhao F, Zheng C, Zheng ZM, Zhuang HL, Zhukov V, Zichichi A, Zimmermann N, and Zuccon P
Abstract: We report the observation of new properties of primary iron (Fe) cosmic rays in the rigidity range 2.65 GV to 3.0 TV with 0.62×10^{6} iron nuclei collected by the Alpha Magnetic Spectrometer experiment on the International Space Station. Above 80.5 GV the rigidity dependence of the cosmic ray Fe flux is identical to the rigidity dependence of the primary cosmic ray He, C, and O fluxes, with the Fe/O flux ratio being constant at 0.155±0.006. This shows that unexpectedly Fe and He, C, and O belong to the same class of primary cosmic rays which is different from the primary cosmic rays Ne, Mg, and Si class.
Published: 2021
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16. Cervical carcinomas with serous-like papillary and micropapillary components: illustrating the heterogeneity of primary cervical carcinomas.

Author: Wong RW, Ng JHY, Han KC, Leung YP, Shek CM, Cheung KN, Choi CKM, Tse KY, and Ip PPC
Subjects: Adenocarcinoma, Papillary chemistry, Adenocarcinoma, Papillary genetics, Adenocarcinoma, Papillary virology, Adult, Aged, Aged, 80 and over, Alphapapillomavirus isolation & purification, Biomarkers, Tumor analysis, Biomarkers, Tumor genetics, Biopsy, Carcinoma, Adenosquamous chemistry, Carcinoma, Adenosquamous genetics, Carcinoma, Adenosquamous virology, DNA Mutational Analysis, Female, Humans, Immunohistochemistry, Middle Aged, Mutation, Missense, Neoplasms, Cystic, Mucinous, and Serous chemistry, Neoplasms, Cystic, Mucinous, and Serous genetics, Neoplasms, Cystic, Mucinous, and Serous virology, Predictive Value of Tests, Prognosis, Retrospective Studies, Terminology as Topic, Uterine Cervical Neoplasms chemistry, Uterine Cervical Neoplasms genetics, Uterine Cervical Neoplasms virology, Adenocarcinoma, Papillary pathology, Carcinoma, Adenosquamous pathology, Neoplasms, Cystic, Mucinous, and Serous pathology, Uterine Cervical Neoplasms pathology
Abstract: Recent changes in the classification of cervical adenocarcinomas have re-categorized serous carcinoma as potentially nonexistent. However, clinical and pathological profiles of cervical adenocarcinomas with serous-like morphological features have not been systematically evaluated using the latest taxonomy and biomarkers. We studied 14 cases of primary cervical carcinomas with serous-like morphologies (papillary and micropapillary patterns). None of these cases exhibited evidence of serous carcinoma involving the upper tracts. Patient ages ranged between 34 and 86 years, most presented with abnormal uterine bleeding. Histologically, ten cases were classified as human papillomavirus (HPV)-associated carcinomas (eight usual-type endocervical adenocarcinomas and two adenosquamous carcinomas), of which six exhibited a papillary pattern and four had a micropapillary pattern. The four remaining cases were HPV-independent gastric-type adenocarcinomas, which displayed a papillary pattern in one case and a micropapillary pattern in three others. All ten HPV-associated carcinomas displayed block positive p16 and wild-type p53 by immunohistochemistry, with nine of them confirmed by HPV testing. Two of the four gastric-type adenocarcinomas had mutation-type p53, one of which also being p16 block positive. HER2 overexpression was demonstrated in 3/14 (21.4%) cases (2 HPV-associated and 1 HPV-independent). PD-L1 expression was identified in 4/10 (40%) cases, all HPV-associated. Targeted next-generation sequencing was performed in two cases with a micropapillary pattern, revealing a missense variant in ATM in an HPV-associated tumor and missense variants in TP53 and SMARCB1 in an HPV-independent tumor. The results demonstrated that primary endocervical adenocarcinomas can mimic the appearance of serous carcinoma, while not representing serous carcinoma. Serous-like papillary and micropapillary patterns may be present in both HPV-associated and HPV-independent cervical carcinomas, but none of the cases studied were unequivocally serous upon detailed analysis. Our findings support the exclusion of "cervical serous carcinoma" from existing classifications of cervical adenocarcinoma.
Published: 2021
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17. HSP90 Inhibitor, 17-DMAG, Alone and in Combination with Lapatinib Attenuates Acquired Lapatinib-Resistance in ER-positive, HER2-Overexpressing Breast Cancer Cell Line.

Author: Lee HJ, Shin S, Kang J, Han KC, Kim YH, Bae JW, and Park KH
Abstract: Lapatinib, a Human Epidermal growth factor Receptor 2 (HER2)-targeting therapy in HER2-overexpressing breast cancer, has been widely used clinically, but the prognosis is still poor because most patients acquire resistance. Therefore, we investigated mechanisms related to lapatinib resistance to evaluate new therapeutic targets that may overcome resistance. Lapatinib-resistant cell lines were established using SKBR3 and BT474 cells. We evaluated cell viability and cell signal changes, gene expression and protein changes. In the xenograft mouse model, anti-tumor effects were evaluated using drugs. Analysis of the protein interaction network in two resistant cell lines with different lapatinib resistance mechanisms showed that HSP90 protein was commonly increased. When Heat Shock Protein 90 (HSP90) inhibitors were administered alone to both resistant cell lines, cell proliferation and protein expression were effectively inhibited. However, inhibition of cell proliferation and protein expression with a combination of lapatinib and HSP90 inhibitors showed a more synergistic effect in the LR-BT474 cell line than the LR-SKBR3 cell line, and the same result was exhibited with the xenograft model. These results suggest that HSP90 inhibitors in patients with lapatinib-resistant Estrogen Receptor (ER) (+) HER2 (+) breast cancer are promising therapeutics for future clinical trials.
Published: 2020
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18. Properties of Neon, Magnesium, and Silicon Primary Cosmic Rays Results from the Alpha Magnetic Spectrometer.

Author: Aguilar M, Ali Cavasonza L, Ambrosi G, Arruda L, Attig N, Barao F, Barrin L, Bartoloni A, Başeğmez-du Pree S, Battiston R, Becker U, Behlmann M, Beischer B, Berdugo J, Bertucci B, Bindi V, de Boer W, Bollweg K, Borgia B, Boschini MJ, Bourquin M, Bueno EF, Burger J, Burger WJ, Burmeister S, Cai XD, Capell M, Casaus J, Castellini G, Cervelli F, Chang YH, Chen GM, Chen HS, Chen Y, Cheng L, Chou HY, Chouridou S, Choutko V, Chung CH, Clark C, Coignet G, Consolandi C, Contin A, Corti C, Cui Z, Dadzie K, Dai YM, Delgado C, Della Torre S, Demirköz MB, Derome L, Di Falco S, Di Felice V, Díaz C, Dimiccoli F, von Doetinchem P, Dong F, Donnini F, Duranti M, Egorov A, Eline A, Feng J, Fiandrini E, Fisher P, Formato V, Freeman C, Galaktionov Y, Gámez C, García-López RJ, Gargiulo C, Gast H, Gebauer I, Gervasi M, Giovacchini F, Gómez-Coral DM, Gong J, Goy C, Grabski V, Grandi D, Graziani M, Guo KH, Haino S, Han KC, Hashmani RK, He ZH, Heber B, Hsieh TH, Hu JY, Huang ZC, Incagli M, Jang WY, Jia Y, Jinchi H, Kanishev K, Khiali B, Kim GN, Kirn T, Konyushikhin M, Kounina O, Kounine A, Koutsenko V, Kuhlman A, Kulemzin A, La Vacca G, Laudi E, Laurenti G, Lazzizzera I, Lebedev A, Lee HT, Lee SC, Li JQ, Li M, Li Q, Li S, Li TX, Li ZH, Light C, Lin CH, Lippert T, Liu Z, Lu SQ, Lu YS, Luebelsmeyer K, Luo JZ, Lyu SS, Machate F, Mañá C, Marín J, Marquardt J, Martin T, Martínez G, Masi N, Maurin D, Menchaca-Rocha A, Meng Q, Mo DC, Molero M, Mott P, Mussolin L, Ni JQ, Nikonov N, Nozzoli F, Oliva A, Orcinha M, Palermo M, Palmonari F, Paniccia M, Pashnin A, Pauluzzi M, Pensotti S, Phan HD, Piandani R, Plyaskin V, Poluianov S, Qi XM, Qin X, Qu ZY, Quadrani L, Rancoita PG, Rapin D, Reina Conde A, Rosier-Lees S, Rozhkov A, Rozza D, Sagdeev R, Schael S, Schmidt SM, Schulz von Dratzig A, Schwering G, Seo ES, Shan BS, Shi JY, Siedenburg T, Solano C, Sonnabend R, Song JW, Sun Q, Sun ZT, Tacconi M, Tang XW, Tang ZC, Tian J, Ting SCC, Ting SM, Tomassetti N, Torsti J, Tüysüz C, Urban T, Usoskin I, Vagelli V, Vainio R, Valente E, Valtonen E, Vázquez Acosta M, Vecchi M, Velasco M, Vialle JP, Wallmann C, Wang LQ, Wang NH, Wang QL, Wang S, Wang X, Wang ZX, Wei J, Weng ZL, Wu H, Xiong RQ, Xu W, Yan Q, Yang Y, Yi H, Yu YJ, Yu ZQ, Zannoni M, Zhang C, Zhang F, Zhang FZ, Zhang JH, Zhang Z, Zhao F, Zheng ZM, Zhuang HL, Zhukov V, Zichichi A, Zimmermann N, and Zuccon P
Abstract: We report the observation of new properties of primary cosmic rays, neon (Ne), magnesium (Mg), and silicon (Si), measured in the rigidity range 2.15 GV to 3.0 TV with 1.8×10^{6} Ne, 2.2×10^{6} Mg, and 1.6×10^{6} Si nuclei collected by the Alpha Magnetic Spectrometer experiment on the International Space Station. The Ne and Mg spectra have identical rigidity dependence above 3.65 GV. The three spectra have identical rigidity dependence above 86.5 GV, deviate from a single power law above 200 GV, and harden in an identical way. Unexpectedly, above 86.5 GV the rigidity dependence of primary cosmic rays Ne, Mg, and Si spectra is different from the rigidity dependence of primary cosmic rays He, C, and O. This shows that the Ne, Mg, and Si and He, C, and O are two different classes of primary cosmic rays.
Published: 2020
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19. Streamlined selection of cancer antigens for vaccine development through integrative multi-omics and high-content cell imaging.

Author: Han KC, Park D, Ju S, Lee YE, Heo SH, Kim YA, Lee JE, Lee Y, Park KH, Park SH, Lee HJ, Lee C, and Jang M
Subjects: Gas Chromatography-Mass Spectrometry, HLA Antigens immunology, High-Throughput Screening Assays, Humans, Proteomics methods, Receptors, Antigen, T-Cell immunology, Triple Negative Breast Neoplasms immunology, Antigens, Neoplasm immunology, Cancer Vaccines immunology
Abstract: Identification of tumor antigens that induce cytotoxic T lymphocytes (CTLs) is crucial for cancer-vaccine development. Despite their predictive ability, current algorithmic approaches and human leukocyte antigen (HLA)-peptidomic analysis allow limited selectivity. Here, we optimized a method to rapidly screen and identify highly immunogenic epitopes that trigger CTL responses. We used a combined application of this method involving immune-specific signature analysis and HLA-associated peptidomics using samples from six patients with triple-negative breast cancer (TNBC) in order to select immunogenic HLA epitopes for in vitro testing. Additionally, we applied high-throughput imaging at the single-cell level in order to confirm the immunoreactivity of the selected peptides. The results indicated that this method enabled identification of promising CTL peptides capable of inducing antitumor immunity. This platform combining high-resolution computational analysis, HLA-peptidomics, and high-throughput immunogenicity testing allowed rapid and robust identification of highly immunogenic epitopes and represents a powerful technique for cancer-vaccine development.
Published: 2020
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20. Attosecond Pulse Amplification in a Plasma-Based X-Ray Laser Dressed by an Infrared Laser Field.

Author: Antonov VA, Han KC, Akhmedzhanov TR, Scully M, and Kocharovskaya O
Abstract: High-harmonic generation (HHG) of laser radiation has led to attosecond pulse formation which offers unprecedented temporal resolution in observing and controlling electron and nuclear dynamics. But the energy of attosecond pulses remains quite small, especially for photon energies exceeding 100 eV, which limits their practical applications. We propose a method for amplification of attosecond pulses in the active medium of a plasma-based x-ray laser dressed by a replica of the laser field used for HHG. The experimental implementation is suggested in hydrogenlike C5+ x-ray laser at 3.4 nm wavelength in the "water window" range.
Published: 2019
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21. Corrigendum to "A carrier-free multiplexed gene editing system applicable for suspension cells" [Biomaterials 217 (2019) 119298].

Author: Ju A, Lee S, Lee YE, Han KC, Kim JC, Shin SC, Park HJ, EunKyeong Kim E, Hong S, and Jang M
Published: 2019
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22. Properties of Cosmic Helium Isotopes Measured by the Alpha Magnetic Spectrometer.

Author: Aguilar M, Ali Cavasonza L, Ambrosi G, Arruda L, Attig N, Bachlechner A, Barao F, Barrau A, Barrin L, Bartoloni A, Başeğmez-du Pree S, Battiston R, Becker U, Behlmann M, Beischer B, Berdugo J, Bertucci B, Bindi V, de Boer W, Bollweg K, Borgia B, Boschini MJ, Bourquin M, Bueno EF, Burger J, Burger WJ, Cai XD, Capell M, Caroff S, Casaus J, Castellini G, Cervelli F, Chang YH, Chen GM, Chen HS, Chen Y, Cheng L, Chou HY, Choutko V, Chung CH, Clark C, Coignet G, Consolandi C, Contin A, Corti C, Cui Z, Dadzie K, Dai YM, Datta A, Delgado C, Della Torre S, Demirköz MB, Derome L, Di Falco S, Di Felice V, Díaz C, Dimiccoli F, von Doetinchem P, Dong F, Donnini F, Duranti M, Egorov A, Eline A, Feng J, Fiandrini E, Fisher P, Formato V, Galaktionov Y, Gámez C, García-López RJ, Gargiulo C, Gast H, Gebauer I, Gervasi M, Giovacchini F, Gómez-Coral DM, Gong J, Goy C, Grabski V, Grandi D, Graziani M, Guo KH, Haino S, Han KC, He ZH, Hsieh TH, Huang H, Huang ZC, Incagli M, Jang WY, Jia Y, Jinchi H, Kanishev K, Khiali B, Kim GN, Kirn T, Konyushikhin M, Kounina O, Kounine A, Koutsenko V, Kulemzin A, La Vacca G, Laudi E, Laurenti G, Lazzizzera I, Lebedev A, Lee HT, Lee SC, Li JQ, Li Q, Li TX, Li ZH, Light C, Lin CH, Lippert T, Liu Z, Lu SQ, Lu YS, Luebelsmeyer K, Luo F, Luo JZ, Luo X, Lyu SS, Machate F, Mañá C, Marín J, Martin T, Martínez G, Masi N, Maurin D, Menchaca-Rocha A, Meng Q, Mo DC, Molero M, Mott P, Mussolin L, Nelson T, Ni JQ, Nikonov N, Nozzoli F, Oliva A, Orcinha M, Palermo M, Palmonari F, Paniccia M, Pashnin A, Pauluzzi M, Pensotti S, Phan HD, Plyaskin V, Poireau V, Poluianov S, Popkow A, Qi XM, Qin X, Qu ZY, Quadrani L, Rancoita PG, Rapin D, Reina Conde A, Rosier-Lees S, Rozhkov A, Rozza D, Sagdeev R, Schael S, Schmidt SM, Schulz von Dratzig A, Schwering G, Seo ES, Shan BS, Shi JY, Siedenburg T, Solano C, Song JW, Sun ZT, Tacconi M, Tang XW, Tang ZC, Tian J, Ting SCC, Ting SM, Tomassetti N, Torsti J, Tüysüz C, Urban T, Usoskin I, Vagelli V, Vainio R, Valente E, Valtonen E, Vázquez Acosta M, Vecchi M, Velasco M, Vialle JP, Wang LQ, Wang NH, Wang QL, Wang X, Wang XQ, Wang ZX, Wei J, Weng ZL, Wu H, Xiong RQ, Xu W, Yan Q, Yang Y, Yi H, Yu YJ, Yu ZQ, Zannoni M, Zeissler S, Zhang C, Zhang F, Zhang JH, Zhang Z, Zhao F, Zheng ZM, Zhuang HL, Zhukov V, Zichichi A, Zimmermann N, and Zuccon P
Abstract: Precision measurements by the Alpha Magnetic Spectrometer (AMS) on the International Space Station of ^{3}He and ^{4}He fluxes are presented. The measurements are based on 100 million ^{4}He nuclei in the rigidity range from 2.1 to 21 GV and 18 million ^{3}He from 1.9 to 15 GV collected from May 2011 to November 2017. We observed that the ^{3}He and ^{4}He fluxes exhibit nearly identical variations with time. The relative magnitude of the variations decreases with increasing rigidity. The rigidity dependence of the ^{3}He/^{4}He flux ratio is measured for the first time. Below 4 GV, the ^{3}He/^{4}He flux ratio was found to have a significant long-term time dependence. Above 4 GV, the ^{3}He/^{4}He flux ratio was found to be time independent, and its rigidity dependence is well described by a single power law ∝R^{Δ} with Δ=-0.294±0.004. Unexpectedly, this value is in agreement with the B/O and B/C spectral indices at high energies.
Published: 2019
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23. A carrier-free multiplexed gene editing system applicable for suspension cells.

Author: Ju A, Lee SW, Lee YE, Han KC, Kim JC, Shin SC, Park HJ, EunKyeong Kim E, Hong S, and Jang M
Subjects: Animals, B7-H1 Antigen metabolism, CD8-Positive T-Lymphocytes immunology, CRISPR-Cas Systems genetics, Cell Line, Tumor, Cell Proliferation, Clathrin metabolism, Cytotoxicity, Immunologic, Endocytosis, Hepatitis A Virus Cellular Receptor 2 metabolism, Humans, Immunity, Mice, Inbred C57BL, Mice, Transgenic, Programmed Cell Death 1 Ligand 2 Protein metabolism, Ribonucleoproteins metabolism, Gene Editing, Suspensions chemistry
Abstract: Genetically engineered cells via CRISPR/Cas9 system can serve as powerful sources for cancer immunotherapeutic applications. Furthermore, multiple genetic alterations are necessary to overcome tumor-induced immune-suppressive mechanisms. However, one of the major obstacles is the technical difficulty with efficient multiple gene manipulation of suspension cells due to the low transfection efficacy. Herein, we established a carrier-free multiplexed gene editing platform in a simplified method, which can enhance the function of cytotoxic CD8 + T cells by modulating suspension cancer cells. Our multiple Cas9 ribonucleoproteins (RNPs) enable simultaneous disruption of two programmed cell death 1 (PD-1) ligands, functioning as negative regulators in the immune system, by accessing engineered Cas9 proteins with abilities of complexation and cellular penetration. In addition, combination with electroporation enhanced multiple gene editing efficacy, compared with that by treatment of multiple Cas9 RNPs alone. This procedure resulted in high gene editing at multiple loci of suspension cells. The treatment of multiple Cas9 RNPs targeting both ligands strongly improved Th1-type cytokine production of cytotoxic CD8 + T cells, resulting in synergistic cytotoxic effects against cancer. Simultaneous suppression of PD-L1 and PD-L2 on cancer cells via our developed editing system allows effective anti-tumor immunity. Furthermore, the treatment of multiple Cas9 RNPs targeting PD-L1, PD-L2, and TIM-3 had approximately 70-90% deletion efficacy. Thus, our multiplexed gene editing strategy endows potential clinical utilities in cancer immunotherapy., (Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Published: 2019
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24. Traditional Chinese Medicine-facilitated switch from methadone to buprenorphine-naloxone for treatment of heroin dependence: a case report.

Author: Huang KY, Hsu CH, Yu KC, Yeh YH, Han KC, and Wei HT
Subjects: Humans, Male, Middle Aged, Treatment Outcome, Buprenorphine, Naloxone Drug Combination therapeutic use, Heroin Dependence drug therapy, Medicine, Chinese Traditional, Methadone therapeutic use
Abstract: The switch from methadone to buprenorphine-naloxone for individuals with heroin dependence is associated with several obstacles and challenges. Such patients may experience discomfort from discontinuing methadone, precipitated withdrawal symptoms induced by buprenorphine-naloxone, and poor psychosocial adjustments such as anticipatory anxiety regarding severe opioid withdrawal. We herein describe a 46-year-old man with a history of heroin dependence who underwent Traditional Chinese Medicine (TCM)-facilitated switching from methadone to buprenorphine-naloxone. No precipitated withdrawal was induced by buprenorphine-naloxone. The drug-switching process was successful and smooth. He maintained abstinence from heroin for the following year. In this case, we applied TCM for enhancement of methadone metabolism and detoxification, analgesic effects, and anxiolytic and hypnotic effects during the drug switch. We observed that TCM effectively facilitated the switch from methadone to buprenorphine-naloxone in our case. Further studies regarding TCM-facilitated treatment for heroin dependence should be conducted.
Published: 2019

25. Towards Understanding the Origin of Cosmic-Ray Electrons.

Author: Aguilar M, Ali Cavasonza L, Alpat B, Ambrosi G, Arruda L, Attig N, Azzarello P, Bachlechner A, Barao F, Barrau A, Barrin L, Bartoloni A, Basara L, Başeğmez-du Pree S, Battiston R, Becker U, Behlmann M, Beischer B, Berdugo J, Bertucci B, Bindi V, de Boer W, Bollweg K, Borgia B, Boschini MJ, Bourquin M, Bueno EF, Burger J, Burger WJ, Cai XD, Capell M, Caroff S, Casaus J, Castellini G, Cervelli F, Chang YH, Chen GM, Chen HS, Chen Y, Cheng L, Chou HY, Choutko V, Chung CH, Clark C, Coignet G, Consolandi C, Contin A, Corti C, Crispoltoni M, Cui Z, Dadzie K, Dai YM, Datta A, Delgado C, Della Torre S, Demirköz MB, Derome L, Di Falco S, Di Felice V, Dimiccoli F, Díaz C, von Doetinchem P, Dong F, Donnini F, Duranti M, Egorov A, Eline A, Eronen T, Feng J, Fiandrini E, Fisher P, Formato V, Galaktionov Y, García-López RJ, Gargiulo C, Gast H, Gebauer I, Gervasi M, Giovacchini F, Gómez-Coral DM, Gong J, Goy C, Grabski V, Grandi D, Graziani M, Guo KH, Haino S, Han KC, He ZH, Heil M, Hsieh TH, Huang H, Huang ZC, Incagli M, Jia Y, Jinchi H, Kanishev K, Khiali B, Kirn T, Konak C, Kounina O, Kounine A, Koutsenko V, Kulemzin A, La Vacca G, Laudi E, Laurenti G, Lazzizzera I, Lebedev A, Lee HT, Lee SC, Leluc C, Li JQ, Li Q, Li TX, Li ZH, Light C, Lin CH, Lippert T, Liu FZ, Liu H, Liu Z, Lu SQ, Lu YS, Luebelsmeyer K, Luo F, Luo JZ, Luo X, Lyu SS, Machate F, Mañá C, Marín J, Martin T, Martínez G, Masi N, Maurin D, Menchaca-Rocha A, Meng Q, Mo DC, Molero M, Mott P, Mussolin L, Nelson T, Ni JQ, Nikonov N, Nozzoli F, Oliva A, Orcinha M, Palermo M, Palmonari F, Paniccia M, Pashnin A, Pauluzzi M, Pensotti S, Perrina C, Phan HD, Picot-Clemente N, Plyaskin V, Pohl M, Poireau V, Popkow A, Quadrani L, Qi XM, Qin X, Qu ZY, Rancoita PG, Rapin D, Conde AR, Rosier-Lees S, Rozhkov A, Rozza D, Sagdeev R, Solano C, Schael S, Schmidt SM, von Dratzig AS, Schwering G, Seo ES, Shan BS, Shi JY, Siedenburg T, Song JW, Sun ZT, Tacconi M, Tang XW, Tang ZC, Tian J, Ting SCC, Ting SM, Tomassetti N, Torsti J, Urban T, Vagelli V, Valente E, Valtonen E, Acosta MV, Vecchi M, Velasco M, Vialle JP, Vizán J, Wang LQ, Wang NH, Wang QL, Wang X, Wang XQ, Wang ZX, Wei J, Weng ZL, Wu H, Xiong RQ, Xu W, Yan Q, Yang Y, Yi H, Yu YJ, Yu ZQ, Zannoni M, Zeissler S, Zhang C, Zhang F, Zhang JH, Zhang Z, Zhao F, Zheng ZM, Zhuang HL, Zhukov V, Zichichi A, Zimmermann N, and Zuccon P
Abstract: Precision results on cosmic-ray electrons are presented in the energy range from 0.5 GeV to 1.4 TeV based on 28.1×10^{6} electrons collected by the Alpha Magnetic Spectrometer on the International Space Station. In the entire energy range the electron and positron spectra have distinctly different magnitudes and energy dependences. The electron flux exhibits a significant excess starting from 42.1_{-5.2}^{+5.4} GeV compared to the lower energy trends, but the nature of this excess is different from the positron flux excess above 25.2±1.8 GeV. Contrary to the positron flux, which has an exponential energy cutoff of 810_{-180}^{+310} GeV, at the 5σ level the electron flux does not have an energy cutoff below 1.9 TeV. In the entire energy range the electron flux is well described by the sum of two power law components. The different behavior of the cosmic-ray electrons and positrons measured by the Alpha Magnetic Spectrometer is clear evidence that most high energy electrons originate from different sources than high energy positrons.
Published: 2019
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26. Towards Understanding the Origin of Cosmic-Ray Positrons.

Author: Aguilar M, Ali Cavasonza L, Ambrosi G, Arruda L, Attig N, Azzarello P, Bachlechner A, Barao F, Barrau A, Barrin L, Bartoloni A, Basara L, Başeğmez-du Pree S, Battiston R, Becker U, Behlmann M, Beischer B, Berdugo J, Bertucci B, Bindi V, de Boer W, Bollweg K, Borgia B, Boschini MJ, Bourquin M, Bueno EF, Burger J, Burger WJ, Cai XD, Capell M, Caroff S, Casaus J, Castellini G, Cervelli F, Chang YH, Chen GM, Chen HS, Chen Y, Cheng L, Chou HY, Choutko V, Chung CH, Clark C, Coignet G, Consolandi C, Contin A, Corti C, Crispoltoni M, Cui Z, Dadzie K, Dai YM, Datta A, Delgado C, Della Torre S, Demirköz MB, Derome L, Di Falco S, Dimiccoli F, Díaz C, von Doetinchem P, Dong F, Donnini F, Duranti M, Egorov A, Eline A, Eronen T, Feng J, Fiandrini E, Fisher P, Formato V, Galaktionov Y, García-López RJ, Gargiulo C, Gast H, Gebauer I, Gervasi M, Giovacchini F, Gómez-Coral DM, Gong J, Goy C, Grabski V, Grandi D, Graziani M, Guo KH, Haino S, Han KC, He ZH, Heil M, Hsieh TH, Huang H, Huang ZC, Incagli M, Jia Y, Jinchi H, Kanishev K, Khiali B, Kirn T, Konak C, Kounina O, Kounine A, Koutsenko V, Kulemzin A, La Vacca G, Laudi E, Laurenti G, Lazzizzera I, Lebedev A, Lee HT, Lee SC, Leluc C, Li JQ, Li Q, Li TX, Li ZH, Light C, Lin CH, Lippert T, Liu FZ, Liu H, Liu Z, Lu SQ, Lu YS, Luebelsmeyer K, Luo F, Luo JZ, Luo X, Lyu SS, Machate F, Mañá C, Marín J, Martin T, Martínez G, Masi N, Maurin D, Menchaca-Rocha A, Meng Q, Mo DC, Molero M, Mott P, Mussolin L, Nelson T, Ni JQ, Nikonov N, Nozzoli F, Oliva A, Orcinha M, Palermo M, Palmonari F, Paniccia M, Pashnin A, Pauluzzi M, Pensotti S, Perrina C, Phan HD, Picot-Clemente N, Plyaskin V, Pohl M, Poireau V, Popkow A, Quadrani L, Qi XM, Qin X, Qu ZY, Rancoita PG, Rapin D, Conde AR, Rosier-Lees S, Rozhkov A, Rozza D, Sagdeev R, Solano C, Schael S, Schmidt SM, Schulz von Dratzig A, Schwering G, Seo ES, Shan BS, Shi JY, Siedenburg T, Song JW, Sun ZT, Tacconi M, Tang XW, Tang ZC, Tian J, Ting SCC, Ting SM, Tomassetti N, Torsti J, Urban T, Vagelli V, Valente E, Valtonen E, Vázquez Acosta M, Vecchi M, Velasco M, Vialle JP, Vizán J, Wang LQ, Wang NH, Wang QL, Wang X, Wang XQ, Wang ZX, Wei J, Weng ZL, Wu H, Xiong RQ, Xu W, Yan Q, Yang Y, Yi H, Yu YJ, Yu ZQ, Zannoni M, Zeissler S, Zhang C, Zhang F, Zhang JH, Zhang Z, Zhao F, Zheng ZM, Zhuang HL, Zhukov V, Zichichi A, Zimmermann N, and Zuccon P
Abstract: Precision measurements of cosmic ray positrons are presented up to 1 TeV based on 1.9 million positrons collected by the Alpha Magnetic Spectrometer on the International Space Station. The positron flux exhibits complex energy dependence. Its distinctive properties are (a) a significant excess starting from 25.2±1.8 GeV compared to the lower-energy, power-law trend, (b) a sharp dropoff above 284_{-64}^{+91} GeV, (c) in the entire energy range the positron flux is well described by the sum of a term associated with the positrons produced in the collision of cosmic rays, which dominates at low energies, and a new source term of positrons, which dominates at high energies, and (d) a finite energy cutoff of the source term of E_{s}=810_{-180}^{+310} GeV is established with a significance of more than 4σ. These experimental data on cosmic ray positrons show that, at high energies, they predominantly originate either from dark matter annihilation or from other astrophysical sources.
Published: 2019
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27. Phosphoproteomic analysis reveals PAK2 as a therapeutic target for lapatinib resistance in HER2-positive breast cancer cells.

Author: Chang Y, Park KH, Lee JE, and Han KC
Subjects: Breast Neoplasms drug therapy, Breast Neoplasms genetics, Breast Neoplasms metabolism, Cell Line, Tumor, Cell Survival drug effects, Cell Survival genetics, Drug Resistance, Neoplasm genetics, Female, Humans, Phosphoproteins genetics, Phosphorylation drug effects, Protein Interaction Maps drug effects, Protein Interaction Maps genetics, Protein Kinase Inhibitors pharmacology, Receptor, ErbB-2 antagonists & inhibitors, Receptor, ErbB-2 genetics, Receptor, ErbB-2 metabolism, Signal Transduction drug effects, Signal Transduction genetics, p21-Activated Kinases genetics, p21-Activated Kinases metabolism, Drug Resistance, Neoplasm drug effects, Lapatinib pharmacology, Phosphoproteins metabolism, Proteomics methods, p21-Activated Kinases antagonists & inhibitors
Abstract: The human epidermal growth factor receptor 2 (HER2)-positive breast cancer with overexpression of HER2 accounts for approximately 25% of breast cancers and is more aggressive than other types of breast cancer. Lapatinib has been widely used as a HER2-targeted therapy, however, a number of patients develop lapatinib resistance and still suffer from poor prognosis. Therefore, it is essential to identify novel therapeutic targets that could overcome lapatinib resistance. In this study, we carried out phosphoproteomic analysis of lapatinib sensitive and resistant cell lines (SKBR3 and SKBR3-LR) using stable isotope labeling with amino acids in cell culture (SILAC). We identified 3808 phosphopeptides from 1807 proteins and then analyzed signaling pathways, Gene Ontology, and protein-protein interaction networks. Finally, we identified PAK2 as a therapeutic target from the network analysis and validated that PAK2 knockdown and PAK inhibitor treatment resensitize the lapatinib resistant cells to lapatinib. This results suggest that PAK2 is a potent therapeutic target to overcome acquired lapatinib resistance in HER2-positive breast cancer cells., (Copyright © 2018 Elsevier Inc. All rights reserved.)
Published: 2018
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28. Novel RNA aptamers targeting gastrointestinal cancer biomarkers CEA, CA50 and CA72-4 with superior affinity and specificity.

Author: Pan Q, Law COK, Yung MMH, Han KC, Pon YL, and Lau TCK
Subjects: Adenocarcinoma, Cell Line, Tumor, Cell Survival, DNA analysis, Gastrointestinal Neoplasms genetics, Gene Library, HeLa Cells, Humans, Prognosis, RNA, Neoplasm analysis, SELEX Aptamer Technique, Sensitivity and Specificity, Antigens, Tumor-Associated, Carbohydrate analysis, Aptamers, Nucleotide chemistry, Biomarkers, Tumor analysis, Carcinoembryonic Antigen analysis, Gastrointestinal Neoplasms diagnosis
Abstract: Gastric cancer is the third most common cause of death from cancer in the world and it remains difficult to cure in Western countries, primarily because most patients present with advanced disease. Currently, CEA, CA50 and CA72-4 are commonly used as tumor markers for gastric cancer by immunoassays. However, the drawback and conundrum of immunoassay are the unceasing problem in standardization of quality of antibodies and time/effort for the intensive production. Therefore, there is an urgent need for the development of a standardized assay to detect gastric cancer at the early stage. Aptamers are DNA or RNA oligonucleotides with structural domain which recognize ligands such as proteins with superior affinity and specificity when compared to antibodies. In this study, SELEX (Systematic Evolution of Ligands by Exponential enrichment) technique was adopted to screen a random 30mer RNA library for aptamers targeting CEA, CA50 and CA72-4 respectively. Combined with high-throughput sequencing, we identified 6 aptamers which specifically target for these three biomarkers of gastrointestinal cancer. Intriguingly, the predicted secondary structures of RNA aptamers from each antigen showed significant structural similarity, suggesting the structural recognition between the aptamers and the antigens. Moreover, we determined the dissociation constants of all the aptamers to their corresponding antigens by fluorescence spectroscopy, which further demonstrated high affinities between the aptamers and the antigens. In addition, immunostaining of gastric adenocarcinoma cell line AGS using CEA Aptamer probe showed positive fluorescent signal which proves the potential of the aptamer as a detection tool for gastric cancer. Furthermore, substantially decreased cell viability and growth were observed when human colorectal cell line LS-174T was transfected with each individual aptamers. Taking together, these novel RNA aptamers targeting gastrointestinal cancer biomarker CEA, CA50 and CA72-4 will aid further development and standardization of clinical diagnostic method with better sensitivity and specificity, and potentially future therapeutics development of gastric cancer., Competing Interests: The authors have declared that no competing interests exist.
Published: 2018
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29. Observation of Complex Time Structures in the Cosmic-Ray Electron and Positron Fluxes with the Alpha Magnetic Spectrometer on the International Space Station.

Author: Aguilar M, Cavasonza LA, Ambrosi G, Arruda L, Attig N, Aupetit S, Azzarello P, Bachlechner A, Barao F, Barrau A, Barrin L, Bartoloni A, Basara L, Başeğmez-du Pree S, Battarbee M, Battiston R, Becker U, Behlmann M, Beischer B, Berdugo J, Bertucci B, Bindel KF, Bindi V, de Boer W, Bollweg K, Bonnivard V, Borgia B, Boschini MJ, Bourquin M, Bueno EF, Burger J, Cadoux F, Cai XD, Capell M, Caroff S, Casaus J, Castellini G, Cervelli F, Chae MJ, Chang YH, Chen AI, Chen GM, Chen HS, Chen Y, Cheng L, Chou HY, Choumilov E, Choutko V, Chung CH, Clark C, Clavero R, Coignet G, Consolandi C, Contin A, Corti C, Creus W, Crispoltoni M, Cui Z, Dadzie K, Dai YM, Datta A, Delgado C, Della Torre S, Demirköz MB, Derome L, Di Falco S, Dimiccoli F, Díaz C, von Doetinchem P, Dong F, Donnini F, Duranti M, D'Urso D, Egorov A, Eline A, Eronen T, Feng J, Fiandrini E, Fisher P, Formato V, Galaktionov Y, Gallucci G, García-López RJ, Gargiulo C, Gast H, Gebauer I, Gervasi M, Ghelfi A, Giovacchini F, Gómez-Coral DM, Gong J, Goy C, Grabski V, Grandi D, Graziani M, Guo KH, Haino S, Han KC, He ZH, Heil M, Hsieh TH, Huang H, Huang ZC, Huh C, Incagli M, Ionica M, Jang WY, Jia Y, Jinchi H, Kang SC, Kanishev K, Khiali B, Kim GN, Kim KS, Kirn T, Konak C, Kounina O, Kounine A, Koutsenko V, Kulemzin A, La Vacca G, Laudi E, Laurenti G, Lazzizzera I, Lebedev A, Lee HT, Lee SC, Leluc C, Li HS, Li JQ, Li Q, Li TX, Li ZH, Li ZY, Lim S, Lin CH, Lipari P, Lippert T, Liu D, Liu H, Lordello VD, Lu SQ, Lu YS, Luebelsmeyer K, Luo F, Luo JZ, Lyu SS, Machate F, Mañá C, Marín J, Martin T, Martínez G, Masi N, Maurin D, Menchaca-Rocha A, Meng Q, Mikuni VM, Mo DC, Mott P, Nelson T, Ni JQ, Nikonov N, Nozzoli F, Oliva A, Orcinha M, Palermo M, Palmonari F, Palomares C, Paniccia M, Pauluzzi M, Pensotti S, Perrina C, Phan HD, Picot-Clemente N, Pilo F, Pizzolotto C, Plyaskin V, Pohl M, Poireau V, Quadrani L, Qi XM, Qin X, Qu ZY, Räihä T, Rancoita PG, Rapin D, Ricol JS, Rosier-Lees S, Rozhkov A, Rozza D, Sagdeev R, Schael S, Schmidt SM, von Dratzig AS, Schwering G, Seo ES, Shan BS, Shi JY, Siedenburg T, Son D, Song JW, Tacconi M, Tang XW, Tang ZC, Tescaro D, Ting SCC, Ting SM, Tomassetti N, Torsti J, Türkoğlu C, Urban T, Vagelli V, Valente E, Valtonen E, Vázquez Acosta M, Vecchi M, Velasco M, Vialle JP, Wang LQ, Wang NH, Wang QL, Wang X, Wang XQ, Wang ZX, Wei CC, Weng ZL, Whitman K, Wu H, Wu X, Xiong RQ, Xu W, Yan Q, Yang J, Yang M, Yang Y, Yi H, Yu YJ, Yu ZQ, Zannoni M, Zeissler S, Zhang C, Zhang F, Zhang J, Zhang JH, Zhang SW, Zhang Z, Zheng ZM, Zhuang HL, Zhukov V, Zichichi A, Zimmermann N, and Zuccon P
Abstract: We present high-statistics, precision measurements of the detailed time and energy dependence of the primary cosmic-ray electron flux and positron flux over 79 Bartels rotations from May 2011 to May 2017 in the energy range from 1 to 50 GeV. For the first time, the charge-sign dependent modulation during solar maximum has been investigated in detail by leptons alone. Based on 23.5×10^{6} events, we report the observation of short-term structures on the timescale of months coincident in both the electron flux and the positron flux. These structures are not visible in the e^{+}/e^{-} flux ratio. The precision measurements across the solar polarity reversal show that the ratio exhibits a smooth transition over 830±30 days from one value to another. The midpoint of the transition shows an energy dependent delay relative to the reversal and changes by 260±30 days from 1 to 6 GeV.
Published: 2018
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30. Precision Measurement of Cosmic-Ray Nitrogen and its Primary and Secondary Components with the Alpha Magnetic Spectrometer on the International Space Station.

Author: Aguilar M, Ali Cavasonza L, Alpat B, Ambrosi G, Arruda L, Attig N, Aupetit S, Azzarello P, Bachlechner A, Barao F, Barrau A, Barrin L, Bartoloni A, Basara L, Başeğmez-du Pree S, Battarbee M, Battiston R, Becker U, Behlmann M, Beischer B, Berdugo J, Bertucci B, Bindel KF, Bindi V, de Boer W, Bollweg K, Bonnivard V, Borgia B, Boschini MJ, Bourquin M, Bueno EF, Burger J, Burger WJ, Cai XD, Capell M, Caroff S, Casaus J, Castellini G, Cervelli F, Chang YH, Chen AI, Chen GM, Chen HS, Chen Y, Cheng L, Chou HY, Choumilov E, Choutko V, Chung CH, Clark C, Clavero R, Coignet G, Consolandi C, Contin A, Corti C, Creus W, Crispoltoni M, Cui Z, Dadzie K, Dai YM, Datta A, Delgado C, Della Torre S, Demirköz MB, Derome L, Di Falco S, Dimiccoli F, Díaz C, von Doetinchem P, Dong F, Donnini F, Duranti M, Egorov A, Eline A, Eronen T, Feng J, Fiandrini E, Fisher P, Formato V, Galaktionov Y, Gallucci G, García-López RJ, Gargiulo C, Gast H, Gebauer I, Gervasi M, Ghelfi A, Giovacchini F, Gómez-Coral DM, Gong J, Goy C, Grabski V, Grandi D, Graziani M, Guo KH, Haino S, Han KC, He ZH, Heil M, Hsieh TH, Huang H, Huang ZC, Incagli M, Jia Y, Jinchi H, Kanishev K, Khiali B, Kirn T, Konak C, Kounina O, Kounine A, Koutsenko V, Kulemzin A, La Vacca G, Laudi E, Laurenti G, Lazzizzera I, Lebedev A, Lee HT, Lee SC, Leluc C, Li HS, Li JQ, Li Q, Li TX, Li ZH, Li ZY, Lin CH, Lipari P, Lippert T, Liu D, Liu H, Liu Z, Lordello VD, Lu SQ, Lu YS, Luebelsmeyer K, Luo F, Luo JZ, Lyu SS, Machate F, Mañá C, Marín J, Martin T, Martínez G, Masi N, Maurin D, Menchaca-Rocha A, Meng Q, Mikuni VM, Mo DC, Mott P, Mussolin L, Nelson T, Ni JQ, Nikonov N, Nozzoli F, Oliva A, Orcinha M, Palermo M, Palmonari F, Palomares C, Paniccia M, Pauluzzi M, Pensotti S, Perrina C, Phan HD, Picot-Clemente N, Pilo F, Plyaskin V, Pohl M, Poireau V, Quadrani L, Qi XM, Qin X, Qu ZY, Räihä T, Rancoita PG, Rapin D, Ricol JS, Rosier-Lees S, Rozhkov A, Rozza D, Sagdeev R, Schael S, Schmidt SM, Schulz von Dratzig A, Schwering G, Seo ES, Shan BS, Shi JY, Siedenburg T, Song JW, Tacconi M, Tang XW, Tang ZC, Tescaro D, Tian J, Ting SCC, Ting SM, Tomassetti N, Torsti J, Urban T, Vagelli V, Valente E, Valtonen E, Vázquez Acosta M, Vecchi M, Velasco M, Vialle JP, Wang LQ, Wang NH, Wang QL, Wang X, Wang XQ, Wang ZX, Wei CC, Wei J, Weng ZL, Whitman K, Wu H, Xiong RQ, Xu W, Yan Q, Yang M, Yang Y, Yi H, Yu YJ, Yu ZQ, Zannoni M, Zeissler S, Zhang C, Zhang F, Zhang J, Zhang JH, Zhang SW, Zhang Z, Zheng ZM, Zhuang HL, Zhukov V, Zichichi A, Zimmermann N, and Zuccon P
Abstract: A precision measurement of the nitrogen flux with rigidity (momentum per unit charge) from 2.2 GV to 3.3 TV based on 2.2×10^{6} events is presented. The detailed rigidity dependence of the nitrogen flux spectral index is presented for the first time. The spectral index rapidly hardens at high rigidities and becomes identical to the spectral indices of primary He, C, and O cosmic rays above ∼700 GV. We observed that the nitrogen flux Φ_{N} can be presented as the sum of its primary component Φ_{N}^{P} and secondary component Φ_{N}^{S}, Φ_{N}=Φ_{N}^{P}+Φ_{N}^{S}, and we found Φ_{N} is well described by the weighted sum of the oxygen flux Φ_{O} (primary cosmic rays) and the boron flux Φ_{B} (secondary cosmic rays), with Φ_{N}^{P}=(0.090±0.002)×Φ_{O} and Φ_{N}^{S}=(0.62±0.02)×Φ_{B} over the entire rigidity range. This corresponds to a change of the contribution of the secondary cosmic ray component in the nitrogen flux from 70% at a few GV to <30% above 1 TV.
Published: 2018
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31. Observation of Fine Time Structures in the Cosmic Proton and Helium Fluxes with the Alpha Magnetic Spectrometer on the International Space Station.

Author: Aguilar M, Ali Cavasonza L, Alpat B, Ambrosi G, Arruda L, Attig N, Aupetit S, Azzarello P, Bachlechner A, Barao F, Barrau A, Barrin L, Bartoloni A, Basara L, Başeğmez-du Pree S, Battarbee M, Battiston R, Becker U, Behlmann M, Beischer B, Berdugo J, Bertucci B, Bindel KF, Bindi V, de Boer W, Bollweg K, Bonnivard V, Borgia B, Boschini MJ, Bourquin M, Bueno EF, Burger J, Cadoux F, Cai XD, Capell M, Caroff S, Casaus J, Castellini G, Cervelli F, Chae MJ, Chang YH, Chen AI, Chen GM, Chen HS, Chen Y, Cheng L, Chou HY, Choumilov E, Choutko V, Chung CH, Clark C, Clavero R, Coignet G, Consolandi C, Contin A, Corti C, Creus W, Crispoltoni M, Cui Z, Dadzie K, Dai YM, Datta A, Delgado C, Della Torre S, Demirköz MB, Derome L, Di Falco S, Dimiccoli F, Díaz C, von Doetinchem P, Dong F, Donnini F, Duranti M, D'Urso D, Egorov A, Eline A, Eronen T, Feng J, Fiandrini E, Fisher P, Formato V, Galaktionov Y, Gallucci G, García-López RJ, Gargiulo C, Gast H, Gebauer I, Gervasi M, Ghelfi A, Giovacchini F, Gómez-Coral DM, Gong J, Goy C, Grabski V, Grandi D, Graziani M, Guo KH, Haino S, Han KC, He ZH, Heil M, Hoffman J, Hsieh TH, Huang H, Huang ZC, Huh C, Incagli M, Ionica M, Jang WY, Jia Y, Jinchi H, Kang SC, Kanishev K, Khiali B, Kim GN, Kim KS, Kirn T, Konak C, Kounina O, Kounine A, Koutsenko V, Kulemzin A, La Vacca G, Laudi E, Laurenti G, Lazzizzera I, Lebedev A, Lee HT, Lee SC, Leluc C, Li HS, Li JQ, Li Q, Li TX, Li ZH, Li ZY, Light C, Lim S, Lin CH, Lipari P, Lippert T, Liu D, Liu H, Lordello VD, Lu SQ, Lu YS, Luebelsmeyer K, Luo F, Luo JZ, Luo X, Lyu SS, Machate F, Mañá C, Marín J, Martin T, Martínez G, Masi N, Maurin D, Menchaca-Rocha A, Meng Q, Mikuni VM, Mo DC, Mott P, Nelson T, Ni JQ, Nikonov N, Nozzoli F, Oliva A, Orcinha M, Palermo M, Palmonari F, Palomares C, Paniccia M, Pauluzzi M, Pensotti S, Perrina C, Phan HD, Picot-Clemente N, Pilo F, Pizzolotto C, Plyaskin V, Pohl M, Poireau V, Popkow A, Quadrani L, Qi XM, Qin X, Qu ZY, Räihä T, Rancoita PG, Rapin D, Ricol JS, Rosier-Lees S, Rozhkov A, Rozza D, Sagdeev R, Schael S, Schmidt SM, Schulz von Dratzig A, Schwering G, Seo ES, Shan BS, Shi JY, Siedenburg T, Son D, Song JW, Tacconi M, Tang XW, Tang ZC, Tescaro D, Ting SCC, Ting SM, Tomassetti N, Torsti J, Türkoğlu C, Urban T, Vagelli V, Valente E, Valtonen E, Vázquez Acosta M, Vecchi M, Velasco M, Vialle JP, Wang LQ, Wang NH, Wang QL, Wang X, Wang XQ, Wang ZX, Wei CC, Weng ZL, Whitman K, Wu H, Wu X, Xiong RQ, Xu W, Yan Q, Yang J, Yang M, Yang Y, Yi H, Yu YJ, Yu ZQ, Zannoni M, Zeissler S, Zhang C, Zhang F, Zhang J, Zhang JH, Zhang SW, Zhang Z, Zheng ZM, Zhuang HL, Zhukov V, Zichichi A, Zimmermann N, and Zuccon P
Abstract: We present the precision measurement from May 2011 to May 2017 (79 Bartels rotations) of the proton fluxes at rigidities from 1 to 60 GV and the helium fluxes from 1.9 to 60 GV based on a total of 1×10^{9} events collected with the Alpha Magnetic Spectrometer aboard the International Space Station. This measurement is in solar cycle 24, which has the solar maximum in April 2014. We observed that, below 40 GV, the proton flux and the helium flux show nearly identical fine structures in both time and relative amplitude. The amplitudes of the flux structures decrease with increasing rigidity and vanish above 40 GV. The amplitudes of the structures are reduced during the time period, which started one year after solar maximum, when the proton and helium fluxes steadily increase. Above ∼3 GV the p/He flux ratio is time independent. We observed that below ∼3 GV the ratio has a long-term decrease coinciding with the period during which the fluxes start to rise.
Published: 2018
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32. Stemness-Attenuating miR-503-3p as a Paracrine Factor to Regulate Growth of Cancer Stem Cells.

Author: Seo M, Kim SM, Woo EY, Han KC, Park EJ, Ko S, Choi EW, and Jang M
Abstract: Cancer stem cells (CSCs) with self-renewal abilities endorse cellular heterogeneity, resulting in metastasis and recurrence. However, there are no promising therapeutics directed against CSCs. Herein, we found that miR-503-3p inhibited tumor growth via the regulation of CSC proliferation and self-renewal. miR-503-3p, isolated from human adipose stem cell- (ASC-) derived exosomes, suppressed initiation and progression of CSCs as determined by anchorage-dependent (colony formation) and anchorage-independent (tumorsphere formation) assays. The expression of pluripotency genes was significantly decreased in miR-503-3p-treated CSCs. Furthermore, xenografts, which received miR-503-3p, exhibited remarkably reduced tumor growth in vivo . Thus, miR-503-3p may function as a stemness-attenuating factor via cell-to-cell communications.
Published: 2018
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33. Observation of New Properties of Secondary Cosmic Rays Lithium, Beryllium, and Boron by the Alpha Magnetic Spectrometer on the International Space Station.

Author: Aguilar M, Ali Cavasonza L, Ambrosi G, Arruda L, Attig N, Aupetit S, Azzarello P, Bachlechner A, Barao F, Barrau A, Barrin L, Bartoloni A, Basara L, Başeğmez-du Pree S, Battarbee M, Battiston R, Becker U, Behlmann M, Beischer B, Berdugo J, Bertucci B, Bindel KF, Bindi V, de Boer W, Bollweg K, Bonnivard V, Borgia B, Boschini MJ, Bourquin M, Bueno EF, Burger J, Burger WJ, Cadoux F, Cai XD, Capell M, Caroff S, Casaus J, Castellini G, Cervelli F, Chae MJ, Chang YH, Chen AI, Chen GM, Chen HS, Cheng L, Chou HY, Choumilov E, Choutko V, Chung CH, Clark C, Clavero R, Coignet G, Consolandi C, Contin A, Corti C, Creus W, Crispoltoni M, Cui Z, Dadzie K, Dai YM, Datta A, Delgado C, Della Torre S, Demirköz MB, Derome L, Di Falco S, Dimiccoli F, Díaz C, von Doetinchem P, Dong F, Donnini F, Duranti M, D'Urso D, Egorov A, Eline A, Eronen T, Feng J, Fiandrini E, Fisher P, Formato V, Galaktionov Y, Gallucci G, García-López RJ, Gargiulo C, Gast H, Gebauer I, Gervasi M, Ghelfi A, Giovacchini F, Gómez-Coral DM, Gong J, Goy C, Grabski V, Grandi D, Graziani M, Guo KH, Haino S, Han KC, He ZH, Heil M, Hsieh TH, Huang H, Huang ZC, Huh C, Incagli M, Ionica M, Jang WY, Jia Y, Jinchi H, Kang SC, Kanishev K, Khiali B, Kim GN, Kim KS, Kirn T, Konak C, Kounina O, Kounine A, Koutsenko V, Kulemzin A, La Vacca G, Laudi E, Laurenti G, Lazzizzera I, Lebedev A, Lee HT, Lee SC, Leluc C, Li HS, Li JQ, Li Q, Li TX, Li Y, Li ZH, Li ZY, Lim S, Lin CH, Lipari P, Lippert T, Liu D, Liu H, Lordello VD, Lu SQ, Lu YS, Luebelsmeyer K, Luo F, Luo JZ, Lyu SS, Machate F, Mañá C, Marín J, Martin T, Martínez G, Masi N, Maurin D, Menchaca-Rocha A, Meng Q, Mikuni VM, Mo DC, Mott P, Nelson T, Ni JQ, Nikonov N, Nozzoli F, Oliva A, Orcinha M, Palermo M, Palmonari F, Palomares C, Paniccia M, Pauluzzi M, Pensotti S, Perrina C, Phan HD, Picot-Clemente N, Pilo F, Pizzolotto C, Plyaskin V, Pohl M, Poireau V, Quadrani L, Qi XM, Qin X, Qu ZY, Räihä T, Rancoita PG, Rapin D, Ricol JS, Rosier-Lees S, Rozhkov A, Rozza D, Sagdeev R, Schael S, Schmidt SM, Schulz von Dratzig A, Schwering G, Seo ES, Shan BS, Shi JY, Siedenburg T, Son D, Song JW, Tacconi M, Tang XW, Tang ZC, Tescaro D, Ting SCC, Ting SM, Tomassetti N, Torsti J, Türkoğlu C, Urban T, Vagelli V, Valente E, Valtonen E, Vázquez Acosta M, Vecchi M, Velasco M, Vialle JP, Vitale V, Wang LQ, Wang NH, Wang QL, Wang X, Wang XQ, Wang ZX, Wei CC, Weng ZL, Whitman K, Wu H, Wu X, Xiong RQ, Xu W, Yan Q, Yang J, Yang M, Yang Y, Yi H, Yu YJ, Yu ZQ, Zannoni M, Zeissler S, Zhang C, Zhang F, Zhang J, Zhang JH, Zhang SW, Zhang Z, Zheng ZM, Zhuang HL, Zhukov V, Zichichi A, Zimmermann N, and Zuccon P
Abstract: We report on the observation of new properties of secondary cosmic rays Li, Be, and B measured in the rigidity (momentum per unit charge) range 1.9 GV to 3.3 TV with a total of 5.4×10^{6} nuclei collected by AMS during the first five years of operation aboard the International Space Station. The Li and B fluxes have an identical rigidity dependence above 7 GV and all three fluxes have an identical rigidity dependence above 30 GV with the Li/Be flux ratio of 2.0±0.1. The three fluxes deviate from a single power law above 200 GV in an identical way. This behavior of secondary cosmic rays has also been observed in the AMS measurement of primary cosmic rays He, C, and O but the rigidity dependences of primary cosmic rays and of secondary cosmic rays are distinctly different. In particular, above 200 GV, the secondary cosmic rays harden more than the primary cosmic rays.
Published: 2018
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34. Identification of Plasma Membrane Glycoproteins Specific to Human Glioblastoma Multiforme Cells Using Lectin Arrays and LC-MS/MS.

Author: Park YE, Yeom J, Kim Y, Lee HJ, Han KC, Lee ST, Lee C, and Lee JE
Subjects: Brain Neoplasms metabolism, Brain Neoplasms pathology, Glioblastoma pathology, Glycosylation, Humans, Tumor Cells, Cultured, Biomarkers, Tumor metabolism, Cell Membrane metabolism, Chromatography, Liquid methods, Glioblastoma metabolism, Lectins metabolism, Membrane Glycoproteins metabolism, Tandem Mass Spectrometry methods
Abstract: Glioblastoma, also known as glioblastoma multiforme (GBM), is the most malignant type of brain cancer and has poor prognosis with a median survival of less than one year. While the structural changes of tumor cell surface carbohydrates are known to be associated with invasive behavior of tumor cells, the cell surface glycoproteins to differentiate the low- and high-grade glioma cells can be potential diagnostic markers and therapeutic targets for GBMs. In the present study, lectin arrays consisting of eight lectins were employed to explore cell surface carbohydrate expression patterns on low-grade oligodendroglioma cells (Hs683) and GBM cells (T98G). Griffonia simplicifolia I (GS I) was found to selectively bind to T98G cells and not to Hs683 cells. For identification of the glioblastoma-specific cell surface markers, the glycoproteins from each cell type were captured by a GS I lectin column and analyzed by LC-MS/MS. The identified proteins from the two cell types were quantified using label-free quantitative analysis based on spectral counting. Of cell surface glycoproteins showing significant increases in T98G cells, five proteins were selected for verification of both protein and glycosylation level changes using Western blot and GS I lectin-based immunosorbent assay., (© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
Published: 2018
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35. Observation of the Identical Rigidity Dependence of He, C, and O Cosmic Rays at High Rigidities by the Alpha Magnetic Spectrometer on the International Space Station.

Author: Aguilar M, Ali Cavasonza L, Alpat B, Ambrosi G, Arruda L, Attig N, Aupetit S, Azzarello P, Bachlechner A, Barao F, Barrau A, Barrin L, Bartoloni A, Basara L, Başeğmez-du Pree S, Battarbee M, Battiston R, Becker U, Behlmann M, Beischer B, Berdugo J, Bertucci B, Bindel KF, Bindi V, de Boer W, Bollweg K, Bonnivard V, Borgia B, Boschini MJ, Bourquin M, Bueno EF, Burger J, Burger WJ, Cadoux F, Cai XD, Capell M, Caroff S, Casaus J, Castellini G, Cervelli F, Chae MJ, Chang YH, Chen AI, Chen GM, Chen HS, Cheng L, Chou HY, Choumilov E, Choutko V, Chung CH, Clark C, Clavero R, Coignet G, Consolandi C, Contin A, Corti C, Creus W, Crispoltoni M, Cui Z, Dadzie K, Dai YM, Datta A, Delgado C, Della Torre S, Demakov O, Demirköz MB, Derome L, Di Falco S, Dimiccoli F, Díaz C, von Doetinchem P, Dong F, Donnini F, Duranti M, D'Urso D, Egorov A, Eline A, Eronen T, Feng J, Fiandrini E, Fisher P, Formato V, Galaktionov Y, Gallucci G, García-López RJ, Gargiulo C, Gast H, Gebauer I, Gervasi M, Ghelfi A, Giovacchini F, Gómez-Coral DM, Gong J, Goy C, Grabski V, Grandi D, Graziani M, Guo KH, Haino S, Han KC, He ZH, Heil M, Hoffman J, Hsieh TH, Huang H, Huang ZC, Huh C, Incagli M, Ionica M, Jang WY, Jia Y, Jinchi H, Kang SC, Kanishev K, Khiali B, Kim GN, Kim KS, Kirn T, Konak C, Kounina O, Kounine A, Koutsenko V, Kulemzin A, La Vacca G, Laudi E, Laurenti G, Lazzizzera I, Lebedev A, Lee HT, Lee SC, Leluc C, Li HS, Li JQ, Li Q, Li TX, Li Y, Li ZH, Li ZY, Lim S, Lin CH, Lipari P, Lippert T, Liu D, Liu H, Lordello VD, Lu SQ, Lu YS, Luebelsmeyer K, Luo F, Luo JZ, Lyu SS, Machate F, Mañá C, Marín J, Martin T, Martínez G, Masi N, Maurin D, Menchaca-Rocha A, Meng Q, Mikuni VM, Mo DC, Mott P, Nelson T, Ni JQ, Nikonov N, Nozzoli F, Oliva A, Orcinha M, Palmonari F, Palomares C, Paniccia M, Pauluzzi M, Pensotti S, Perrina C, Phan HD, Picot-Clemente N, Pilo F, Pizzolotto C, Plyaskin V, Pohl M, Poireau V, Quadrani L, Qi XM, Qin X, Qu ZY, Räihä T, Rancoita PG, Rapin D, Ricol JS, Rosier-Lees S, Rozhkov A, Rozza D, Sagdeev R, Schael S, Schmidt SM, Schulz von Dratzig A, Schwering G, Seo ES, Shan BS, Shi JY, Siedenburg T, Son D, Song JW, Tacconi M, Tang XW, Tang ZC, Tescaro D, Ting SCC, Ting SM, Tomassetti N, Torsti J, Türkoğlu C, Urban T, Vagelli V, Valente E, Valtonen E, Vázquez Acosta M, Vecchi M, Velasco M, Vialle JP, Vitale V, Vitillo S, Wang LQ, Wang NH, Wang QL, Wang X, Wang XQ, Wang ZX, Wei CC, Weng ZL, Whitman K, Wu H, Wu X, Xiong RQ, Xu W, Yan Q, Yang J, Yang M, Yang Y, Yi H, Yu YJ, Yu ZQ, Zannoni M, Zeissler S, Zhang C, Zhang F, Zhang J, Zhang JH, Zhang SW, Zhang Z, Zheng ZM, Zhuang HL, Zhukov V, Zichichi A, Zimmermann N, and Zuccon P
Abstract: We report the observation of new properties of primary cosmic rays He, C, and O measured in the rigidity (momentum/charge) range 2 GV to 3 TV with 90×10^{6} helium, 8.4×10^{6} carbon, and 7.0×10^{6} oxygen nuclei collected by the Alpha Magnetic Spectrometer (AMS) during the first five years of operation. Above 60 GV, these three spectra have identical rigidity dependence. They all deviate from a single power law above 200 GV and harden in an identical way.
Published: 2017
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36. Standardized Cirsium setidens Nakai Ethanolic Extract Suppresses Adipogenesis and Regulates Lipid Metabolisms in 3T3-L1 Adipocytes and C57BL/6J Mice Fed High-Fat Diets.

Author: Cho BY, Park MR, Lee JH, Ra MJ, Han KC, Kang IJ, and Lee OH
Subjects: 3T3-L1 Cells, Adipocytes cytology, Adipocytes metabolism, Animals, CCAAT-Enhancer-Binding Protein-alpha genetics, CCAAT-Enhancer-Binding Protein-alpha metabolism, Diet, High-Fat adverse effects, Fatty Acid Synthases genetics, Fatty Acid Synthases metabolism, Humans, Male, Mice, Mice, Inbred C57BL, Obesity genetics, Obesity metabolism, PPAR gamma genetics, PPAR gamma metabolism, Sterol Regulatory Element Binding Protein 1 genetics, Sterol Regulatory Element Binding Protein 1 metabolism, Adipocytes drug effects, Adipogenesis drug effects, Anti-Obesity Agents administration & dosage, Cirsium chemistry, Lipid Metabolism drug effects, Obesity drug therapy, Plant Extracts administration & dosage
Abstract: Cirsium setidens Nakai, a wild perennial herb, grows mainly in Gangwon province, Korea, and has been reported to contain bioactive ingredients with various medicinal activities, including the treatment of edema, bleeding, and hemoptysis. However, the potential antiobesity effects of C. setidens Nakai have not been fully investigated. This study evaluated the antiobesity effect of standardized C. setidens Nakai ethanolic extract (CNE) in 3T3-L1 adipocytes and in obese C57BL/6J mice fed a high-fat diet. CNE suppressed the expression of lipogenic genes and increased the expression of lipolytic genes. The antiadipogenic and antilipogenic effects of CNE appear to be mediated by the inhibition of peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer-binding protein (C/EBP) expressions. Moreover, CNE stimulated fatty acid oxidation in an AMPK-dependent manner. CNE-treated groups of C57BL/6J mice showed reduced body weights and adipose tissue weight and improved serum lipid profiles through the downregulation of PPARγ, C/EBPα, fatty acid binding protein 4 (FABP4), sterol regulatory element binding protein-1c (SREBP-1c), and fatty acid synthase (FAS) and the upregulation of adiponectin and carnitine palmitoyltransferase-1 (CPT-1) in obese C57BL/6J mice fed a high-fat diet. These results suggest that CNE may have an antiobesity effect on adipogenesis and lipid metabolism in vitro and in vivo and present the possibility of developing a treatment for obesity with nontoxic natural resources.
Published: 2017
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37. Prostatic Arterial Embolization for Control of Hematuria in Patients with Advanced Prostate Cancer.

Author: Chen JW, Shin JH, Tsao TF, Ko HG, Yoon HK, Han KC, Thamtorawat S, and Hong B
Subjects: Aged, Aged, 80 and over, Arteries diagnostic imaging, Embolization, Therapeutic adverse effects, Hematuria diagnosis, Hematuria etiology, Humans, Male, Middle Aged, Neoplasm Staging, Prostatic Neoplasms pathology, Radiography, Interventional, Recurrence, Retrospective Studies, Time Factors, Treatment Outcome, Embolization, Therapeutic methods, Hematuria therapy, Prostate blood supply, Prostatic Neoplasms complications
Abstract: Nine patients with advanced prostate cancer (stage T4) underwent prostatic arterial embolization (PAE) for refractory prostatic hematuria. Angiograms showed prostatic neovascularity in all cases, and complete PAE was achieved in 8 cases (89% technical success rate). Gross hematuria ceased after PAE in 6 cases, translating to a 67% clinical success rate. There were no PAE-related complications. At 3-month follow-up, 2 cases showed recurrent hematuria, 4 patients had died from PAE-unrelated etiologies, and only 3 patients survived and were without gross hematuria. PAE could represent an alternative option for patients with advanced prostate cancer to control hematuria., (Copyright © 2016 SIR. Published by Elsevier Inc. All rights reserved.)
Published: 2017
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38. Precision Measurement of the Boron to Carbon Flux Ratio in Cosmic Rays from 1.9 GV to 2.6 TV with the Alpha Magnetic Spectrometer on the International Space Station.

Author: Aguilar M, Ali Cavasonza L, Ambrosi G, Arruda L, Attig N, Aupetit S, Azzarello P, Bachlechner A, Barao F, Barrau A, Barrin L, Bartoloni A, Basara L, Başeğmez-du Pree S, Battarbee M, Battiston R, Becker U, Behlmann M, Beischer B, Berdugo J, Bertucci B, Bindel KF, Bindi V, Boella G, de Boer W, Bollweg K, Bonnivard V, Borgia B, Boschini MJ, Bourquin M, Bueno EF, Burger J, Cadoux F, Cai XD, Capell M, Caroff S, Casaus J, Castellini G, Cervelli F, Chae MJ, Chang YH, Chen AI, Chen GM, Chen HS, Cheng L, Chou HY, Choumilov E, Choutko V, Chung CH, Clark C, Clavero R, Coignet G, Consolandi C, Contin A, Corti C, Creus W, Crispoltoni M, Cui Z, Dai YM, Delgado C, Della Torre S, Demakov O, Demirköz MB, Derome L, Di Falco S, Dimiccoli F, Díaz C, von Doetinchem P, Dong F, Donnini F, Duranti M, D'Urso D, Egorov A, Eline A, Eronen T, Feng J, Fiandrini E, Finch E, Fisher P, Formato V, Galaktionov Y, Gallucci G, García B, García-López RJ, Gargiulo C, Gast H, Gebauer I, Gervasi M, Ghelfi A, Giovacchini F, Goglov P, Gómez-Coral DM, Gong J, Goy C, Grabski V, Grandi D, Graziani M, Guo KH, Haino S, Han KC, He ZH, Heil M, Hoffman J, Hsieh TH, Huang H, Huang ZC, Huh C, Incagli M, Ionica M, Jang WY, Jinchi H, Kang SC, Kanishev K, Kim GN, Kim KS, Kirn T, Konak C, Kounina O, Kounine A, Koutsenko V, Krafczyk MS, La Vacca G, Laudi E, Laurenti G, Lazzizzera I, Lebedev A, Lee HT, Lee SC, Leluc C, Li HS, Li JQ, Li JQ, Li Q, Li TX, Li W, Li Y, Li ZH, Li ZY, Lim S, Lin CH, Lipari P, Lippert T, Liu D, Liu H, Lordello VD, Lu SQ, Lu YS, Luebelsmeyer K, Luo F, Luo JZ, Lv SS, Machate F, Majka R, Mañá C, Marín J, Martin T, Martínez G, Masi N, Maurin D, Menchaca-Rocha A, Meng Q, Mikuni VM, Mo DC, Morescalchi L, Mott P, Nelson T, Ni JQ, Nikonov N, Nozzoli F, Oliva A, Orcinha M, Palmonari F, Palomares C, Paniccia M, Pauluzzi M, Pensotti S, Pereira R, Picot-Clemente N, Pilo F, Pizzolotto C, Plyaskin V, Pohl M, Poireau V, Putze A, Quadrani L, Qi XM, Qin X, Qu ZY, Räihä T, Rancoita PG, Rapin D, Ricol JS, Rosier-Lees S, Rozhkov A, Rozza D, Sagdeev R, Sandweiss J, Saouter P, Schael S, Schmidt SM, Schulz von Dratzig A, Schwering G, Seo ES, Shan BS, Shi JY, Siedenburg T, Son D, Song JW, Sun WH, Tacconi M, Tang XW, Tang ZC, Tao L, Tescaro D, Ting SC, Ting SM, Tomassetti N, Torsti J, Türkoğlu C, Urban T, Vagelli V, Valente E, Vannini C, Valtonen E, Vázquez Acosta M, Vecchi M, Velasco M, Vialle JP, Vitale V, Vitillo S, Wang LQ, Wang NH, Wang QL, Wang X, Wang XQ, Wang ZX, Wei CC, Weng ZL, Whitman K, Wienkenhöver J, Wu H, Wu X, Xia X, Xiong RQ, Xu W, Yan Q, Yang J, Yang M, Yang Y, Yi H, Yu YJ, Yu ZQ, Zeissler S, Zhang C, Zhang J, Zhang JH, Zhang SD, Zhang SW, Zhang Z, Zheng ZM, Zhu ZQ, Zhuang HL, Zhukov V, Zichichi A, Zimmermann N, and Zuccon P
Abstract: Knowledge of the rigidity dependence of the boron to carbon flux ratio (B/C) is important in understanding the propagation of cosmic rays. The precise measurement of the B/C ratio from 1.9 GV to 2.6 TV, based on 2.3 million boron and 8.3 million carbon nuclei collected by AMS during the first 5 years of operation, is presented. The detailed variation with rigidity of the B/C spectral index is reported for the first time. The B/C ratio does not show any significant structures in contrast to many cosmic ray models that require such structures at high rigidities. Remarkably, above 65 GV, the B/C ratio is well described by a single power law R^{Δ} with index Δ=-0.333±0.014(fit)±0.005(syst), in good agreement with the Kolmogorov theory of turbulence which predicts Δ=-1/3 asymptotically.
Published: 2016
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39. Antiproton Flux, Antiproton-to-Proton Flux Ratio, and Properties of Elementary Particle Fluxes in Primary Cosmic Rays Measured with the Alpha Magnetic Spectrometer on the International Space Station.

Author: Aguilar M, Ali Cavasonza L, Alpat B, Ambrosi G, Arruda L, Attig N, Aupetit S, Azzarello P, Bachlechner A, Barao F, Barrau A, Barrin L, Bartoloni A, Basara L, Başeǧmez-du Pree S, Battarbee M, Battiston R, Bazo J, Becker U, Behlmann M, Beischer B, Berdugo J, Bertucci B, Bindi V, Boella G, de Boer W, Bollweg K, Bonnivard V, Borgia B, Boschini MJ, Bourquin M, Bueno EF, Burger J, Cadoux F, Cai XD, Capell M, Caroff S, Casaus J, Castellini G, Cernuda I, Cervelli F, Chae MJ, Chang YH, Chen AI, Chen GM, Chen HS, Cheng L, Chou HY, Choumilov E, Choutko V, Chung CH, Clark C, Clavero R, Coignet G, Consolandi C, Contin A, Corti C, Coste B, Creus W, Crispoltoni M, Cui Z, Dai YM, Delgado C, Della Torre S, Demirköz MB, Derome L, Di Falco S, Dimiccoli F, Díaz C, von Doetinchem P, Dong F, Donnini F, Duranti M, D'Urso D, Egorov A, Eline A, Eronen T, Feng J, Fiandrini E, Finch E, Fisher P, Formato V, Galaktionov Y, Gallucci G, García B, García-López RJ, Gargiulo C, Gast H, Gebauer I, Gervasi M, Ghelfi A, Giovacchini F, Goglov P, Gómez-Coral DM, Gong J, Goy C, Grabski V, Grandi D, Graziani M, Guerri I, Guo KH, Habiby M, Haino S, Han KC, He ZH, Heil M, Hoffman J, Hsieh TH, Huang H, Huang ZC, Huh C, Incagli M, Ionica M, Jang WY, Jinchi H, Kang SC, Kanishev K, Kim GN, Kim KS, Kirn T, Konak C, Kounina O, Kounine A, Koutsenko V, Krafczyk MS, La Vacca G, Laudi E, Laurenti G, Lazzizzera I, Lebedev A, Lee HT, Lee SC, Leluc C, Li HS, Li JQ, Li JQ, Li Q, Li TX, Li W, Li ZH, Li ZY, Lim S, Lin CH, Lipari P, Lippert T, Liu D, Liu H, Lu SQ, Lu YS, Luebelsmeyer K, Luo F, Luo JZ, Lv SS, Majka R, Mañá C, Marín J, Martin T, Martínez G, Masi N, Maurin D, Menchaca-Rocha A, Meng Q, Mo DC, Morescalchi L, Mott P, Nelson T, Ni JQ, Nikonov N, Nozzoli F, Nunes P, Oliva A, Orcinha M, Palmonari F, Palomares C, Paniccia M, Pauluzzi M, Pensotti S, Pereira R, Picot-Clemente N, Pilo F, Pizzolotto C, Plyaskin V, Pohl M, Poireau V, Putze A, Quadrani L, Qi XM, Qin X, Qu ZY, Räihä T, Rancoita PG, Rapin D, Ricol JS, Rodríguez I, Rosier-Lees S, Rozhkov A, Rozza D, Sagdeev R, Sandweiss J, Saouter P, Schael S, Schmidt SM, Schulz von Dratzig A, Schwering G, Seo ES, Shan BS, Shi JY, Siedenburg T, Son D, Song JW, Sun WH, Tacconi M, Tang XW, Tang ZC, Tao L, Tescaro D, Ting SC, Ting SM, Tomassetti N, Torsti J, Türkoğlu C, Urban T, Vagelli V, Valente E, Vannini C, Valtonen E, Vázquez Acosta M, Vecchi M, Velasco M, Vialle JP, Vitale V, Vitillo S, Wang LQ, Wang NH, Wang QL, Wang X, Wang XQ, Wang ZX, Wei CC, Weng ZL, Whitman K, Wienkenhöver J, Willenbrock M, Wu H, Wu X, Xia X, Xiong RQ, Xu W, Yan Q, Yang J, Yang M, Yang Y, Yi H, Yu YJ, Yu ZQ, Zeissler S, Zhang C, Zhang J, Zhang JH, Zhang SD, Zhang SW, Zhang Z, Zheng ZM, Zhu ZQ, Zhuang HL, Zhukov V, Zichichi A, Zimmermann N, and Zuccon P
Abstract: A precision measurement by AMS of the antiproton flux and the antiproton-to-proton flux ratio in primary cosmic rays in the absolute rigidity range from 1 to 450 GV is presented based on 3.49×10^{5} antiproton events and 2.42×10^{9} proton events. The fluxes and flux ratios of charged elementary particles in cosmic rays are also presented. In the absolute rigidity range ∼60 to ∼500 GV, the antiproton p[over ¯], proton p, and positron e^{+} fluxes are found to have nearly identical rigidity dependence and the electron e^{-} flux exhibits a different rigidity dependence. Below 60 GV, the (p[over ¯]/p), (p[over ¯]/e^{+}), and (p/e^{+}) flux ratios each reaches a maximum. From ∼60 to ∼500 GV, the (p[over ¯]/p), (p[over ¯]/e^{+}), and (p/e^{+}) flux ratios show no rigidity dependence. These are new observations of the properties of elementary particles in the cosmos.
Published: 2016
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40. Transcatheter Arterial Embolization of Angiographically Visible and Occult Renal Capsular Artery Hemorrhage in 28 Patients.

Author: Park HJ, Shin JH, Han KC, Yoon HK, Ko GY, and Sung KB
Subjects: Adolescent, Adult, Aged, Biomarkers blood, Embolization, Therapeutic adverse effects, Erythrocyte Transfusion, Female, Hemoglobins metabolism, Hemorrhage blood, Humans, Kidney Diseases blood, Male, Middle Aged, Predictive Value of Tests, Retrospective Studies, Treatment Outcome, Young Adult, Computed Tomography Angiography, Embolization, Therapeutic methods, Hemorrhage diagnostic imaging, Hemorrhage therapy, Kidney Diseases diagnostic imaging, Kidney Diseases therapy, Renal Artery diagnostic imaging
Abstract: Purpose: To evaluate the effectiveness and safety of transcatheter arterial embolization to control bleeding from the renal capsular artery (RCA)., Materials and Methods: Embolization was performed in 28 patients (14 men; mean age, 49.7 y). Presence and type of previous invasive procedures, initial presentation, and coagulation profile were reviewed. Any preceding abdominal computed tomography (CT) findings were analyzed. Angiographic findings were categorized as active bleeding, suspicious for bleeding, or no bleeding. Technical and clinical success and clinical outcomes were evaluated. Changes in hemoglobin level and transfusion volume of packed red blood cells (pBRCs) before and after embolization were evaluated with the paired t test and Wilcoxon signed-rank test, respectively., Results: Technical and clinical success rates of therapeutic embolization for active bleeding (n = 11) were 90.9% and 80%, respectively. One case of technical failure (5.9%) and 3 cases of postembolization bleeding (18.7%) were noted in the prophylactic embolization group in patients with suspicion of bleeding (n = 13) or no bleeding (n = 4). Transient renal insufficiency occurred in 4 patients (14.3%). The average hemoglobin level and volume of transfused pBRCs changed from 8.1 g/dL to 9.9 g/dL and from 871 mL to 543 mL, respectively (P < .05). Extravasation of contrast media or acute hematoma in the right subhepatic or perirenal space on CT was noted in 21 patients (78%)., Conclusions: Embolization can provide an effective and safe method to control RCA bleeding. Perirenal invasive procedures and signs of active or recent right subhepatic or perirenal hemorrhage should raise the suspicion of an RCA source., (Copyright © 2016 SIR. Published by Elsevier Inc. All rights reserved.)
Published: 2016
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41. Depression and Social Support Trajectories During 1 Year Postpartum Among Marriage-Based Immigrant Mothers in Taiwan.

Author: Chen HH, Hwang FM, Lin LJ, Han KC, Lin CL, and Chien LY
Subjects: Adaptation, Psychological, Adult, Asia ethnology, Female, Humans, Surveys and Questionnaires, Taiwan, Depression, Postpartum ethnology, Depression, Postpartum psychology, Emigrants and Immigrants, Mothers psychology, Social Support
Abstract: Objectives: This panel study examined the trajectories of depression and social support during the first year postpartum among marriage-based immigrant mothers in Taiwan, and the effect of social support on depression., Methods: This panel study recruited South-Asia immigrant mothers (mean age: 27years) to complete structured questionnaire at 1month, 6month, and 1year postpartum. A total of 203 immigrant mothers completed structured questionnaires at 1 and 6months, and 163 completed the questionnaires at 1year postpartum. Postpartum depression was measured using the Edinburgh Postpartum Depression Scale. Social support was composed of 3 subscales, emotional, instrumental, and informational support. Hierarchical linear modeling was used to examine the relationships between trajectories and factors associated with depression., Results: Depression and instrumental support followed downward curvilinear trajectories, while emotional and informational support followed upward curvilinear trajectories. Depression was highest at 1month, decreased sharply until 6months, and then leveled off between 6 and 12months. Emotional and instrumental support negatively covaried with postpartum depression over time. When the three-dimensional supports were considered together, only emotional support retained its significance., Conclusions: Our results demonstrated that depression was highest at 1month, then decreased, and then leveled off during 1year postpartum, though further study may be needed to confirm the trajectory. The 3 types of social support differed in postpartum trajectory, suggesting the needs to consider them separately in future studies. To decrease postpartum depression among immigrant mothers, strategies should be developed to increase emotional and instrumental support during postpartum period., (Copyright © 2015 Elsevier Inc. All rights reserved.)
Published: 2016
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42. Precision Measurement of the Helium Flux in Primary Cosmic Rays of Rigidities 1.9 GV to 3 TV with the Alpha Magnetic Spectrometer on the International Space Station.

Author: Aguilar M, Aisa D, Alpat B, Alvino A, Ambrosi G, Andeen K, Arruda L, Attig N, Azzarello P, Bachlechner A, Barao F, Barrau A, Barrin L, Bartoloni A, Basara L, Battarbee M, Battiston R, Bazo J, Becker U, Behlmann M, Beischer B, Berdugo J, Bertucci B, Bindi V, Bizzaglia S, Bizzarri M, Boella G, de Boer W, Bollweg K, Bonnivard V, Borgia B, Borsini S, Boschini MJ, Bourquin M, Burger J, Cadoux F, Cai XD, Capell M, Caroff S, Casaus J, Castellini G, Cernuda I, Cerreta D, Cervelli F, Chae MJ, Chang YH, Chen AI, Chen GM, Chen H, Chen HS, Cheng L, Chou HY, Choumilov E, Choutko V, Chung CH, Clark C, Clavero R, Coignet G, Consolandi C, Contin A, Corti C, Gil EC, Coste B, Creus W, Crispoltoni M, Cui Z, Dai YM, Delgado C, Della Torre S, Demirköz MB, Derome L, Di Falco S, Di Masso L, Dimiccoli F, Díaz C, von Doetinchem P, Donnini F, Duranti M, D'Urso D, Egorov A, Eline A, Eppling FJ, Eronen T, Fan YY, Farnesini L, Feng J, Fiandrini E, Fiasson A, Finch E, Fisher P, Formato V, Galaktionov Y, Gallucci G, García B, García-López R, Gargiulo C, Gast H, Gebauer I, Gervasi M, Ghelfi A, Giovacchini F, Goglov P, Gong J, Goy C, Grabski V, Grandi D, Graziani M, Guandalini C, Guerri I, Guo KH, Haas D, Habiby M, Haino S, Han KC, He ZH, Heil M, Hoffman J, Hsieh TH, Huang ZC, Huh C, Incagli M, Ionica M, Jang WY, Jinchi H, Kanishev K, Kim GN, Kim KS, Kirn T, Korkmaz MA, Kossakowski R, Kounina O, Kounine A, Koutsenko V, Krafczyk MS, La Vacca G, Laudi E, Laurenti G, Lazzizzera I, Lebedev A, Lee HT, Lee SC, Leluc C, Li HL, Li JQ, Li JQ, Li Q, Li Q, Li TX, Li W, Li Y, Li ZH, Li ZY, Lim S, Lin CH, Lipari P, Lippert T, Liu D, Liu H, Liu H, Lolli M, Lomtadze T, Lu MJ, Lu SQ, Lu YS, Luebelsmeyer K, Luo F, Luo JZ, Lv SS, Majka R, Mañá C, Marín J, Martin T, Martínez G, Masi N, Maurin D, Menchaca-Rocha A, Meng Q, Mo DC, Morescalchi L, Mott P, Müller M, Nelson T, Ni JQ, Nikonov N, Nozzoli F, Nunes P, Obermeier A, Oliva A, Orcinha M, Palmonari F, Palomares C, Paniccia M, Papi A, Pauluzzi M, Pedreschi E, Pensotti S, Pereira R, Picot-Clemente N, Pilo F, Piluso A, Pizzolotto C, Plyaskin V, Pohl M, Poireau V, Putze A, Quadrani L, Qi XM, Qin X, Qu ZY, Räihä T, Rancoita PG, Rapin D, Ricol JS, Rodríguez I, Rosier-Lees S, Rozhkov A, Rozza D, Sagdeev R, Sandweiss J, Saouter P, Schael S, Schmidt SM, von Dratzig AS, Schwering G, Scolieri G, Seo ES, Shan BS, Shan YH, Shi JY, Shi XY, Shi YM, Siedenburg T, Son D, Song JW, Spada F, Spinella F, Sun W, Sun WH, Tacconi M, Tang CP, Tang XW, Tang ZC, Tao L, Tescaro D, Ting SC, Ting SM, Tomassetti N, Torsti J, Türkoğlu C, Urban T, Vagelli V, Valente E, Vannini C, Valtonen E, Vaurynovich S, Vecchi M, Velasco M, Vialle JP, Vitale V, Vitillo S, Wang LQ, Wang NH, Wang QL, Wang RS, Wang X, Wang ZX, Weng ZL, Whitman K, Wienkenhöver J, Willenbrock M, Wu H, Wu X, Xia X, Xie M, Xie S, Xiong RQ, Xu NS, Xu W, Yan Q, Yang J, Yang M, Yang Y, Ye QH, Yi H, Yu YJ, Yu ZQ, Zeissler S, Zhang C, Zhang JH, Zhang MT, Zhang SD, Zhang SW, Zhang XB, Zhang Z, Zheng ZM, Zhuang HL, Zhukov V, Zichichi A, Zimmermann N, and Zuccon P
Abstract: Knowledge of the precise rigidity dependence of the helium flux is important in understanding the origin, acceleration, and propagation of cosmic rays. A precise measurement of the helium flux in primary cosmic rays with rigidity (momentum/charge) from 1.9 GV to 3 TV based on 50 million events is presented and compared to the proton flux. The detailed variation with rigidity of the helium flux spectral index is presented for the first time. The spectral index progressively hardens at rigidities larger than 100 GV. The rigidity dependence of the helium flux spectral index is similar to that of the proton spectral index though the magnitudes are different. Remarkably, the spectral index of the proton to helium flux ratio increases with rigidity up to 45 GV and then becomes constant; the flux ratio above 45 GV is well described by a single power law.
Published: 2015
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43. Head Transplantation in Mouse Model.

Author: Ren XP, Ye YJ, Li PW, Shen ZL, Han KC, and Song Y
Subjects: Animals, Brain physiology, Brain Ischemia prevention & control, Electrocardiography, Electroencephalography, Feasibility Studies, Heart physiology, Male, Mice, Mice, Inbred C57BL, Models, Animal, Head surgery, Transplantation, Homologous methods
Abstract: Aims: The mouse model of allo-head and body reconstruction (AHBR) has recently been established to further the clinical development of this strategy for patients who are suffering from mortal bodily trauma or disease, yet whose mind remains healthy. Animal model studies are indispensable for developing such novel surgical practices. The goal of this work was to establish head transplant mouse model, then the next step through the feasible biological model to investigate immune rejection and brain function in next step, thereby promoting the goal of translation of AHBR to the clinic in the future., Methods and Results: Our approach involves retaining adequate blood perfusion in the transplanted head throughout the surgical procedure by establishing donor-to-recipient cross-circulation by cannulating and anastomosing the carotid artery on one side of the body and the jugular vein on the other side. Neurological function was preserved by this strategy as indicated by electroencephalogram and intact cranial nerve reflexes., Conclusions: The results of this study support the feasibility of this method for avoiding brain ischemia during transplantation, thereby allowing for the possibility of long-term studies of head transplantation., (© 2015 John Wiley & Sons Ltd.)
Published: 2015
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44. Precision Measurement of the Proton Flux in Primary Cosmic Rays from Rigidity 1 GV to 1.8 TV with the Alpha Magnetic Spectrometer on the International Space Station.

Author: Aguilar M, Aisa D, Alpat B, Alvino A, Ambrosi G, Andeen K, Arruda L, Attig N, Azzarello P, Bachlechner A, Barao F, Barrau A, Barrin L, Bartoloni A, Basara L, Battarbee M, Battiston R, Bazo J, Becker U, Behlmann M, Beischer B, Berdugo J, Bertucci B, Bigongiari G, Bindi V, Bizzaglia S, Bizzarri M, Boella G, de Boer W, Bollweg K, Bonnivard V, Borgia B, Borsini S, Boschini MJ, Bourquin M, Burger J, Cadoux F, Cai XD, Capell M, Caroff S, Casaus J, Cascioli V, Castellini G, Cernuda I, Cerreta D, Cervelli F, Chae MJ, Chang YH, Chen AI, Chen H, Cheng GM, Chen HS, Cheng L, Chou HY, Choumilov E, Choutko V, Chung CH, Clark C, Clavero R, Coignet G, Consolandi C, Contin A, Corti C, Cortina Gil E, Coste B, Creus W, Crispoltoni M, Cui Z, Dai YM, Delgado C, Della Torre S, Demirköz MB, Derome L, Di Falco S, Di Masso L, Dimiccoli F, Díaz C, von Doetinchem P, Donnini F, Du WJ, Duranti M, D'Urso D, Eline A, Eppling FJ, Eronen T, Fan YY, Farnesini L, Feng J, Fiandrini E, Fiasson A, Finch E, Fisher P, Galaktionov Y, Gallucci G, García B, García-López R, Gargiulo C, Gast H, Gebauer I, Gervasi M, Ghelfi A, Gillard W, Giovacchini F, Goglov P, Gong J, Goy C, Grabski V, Grandi D, Graziani M, Guandalini C, Guerri I, Guo KH, Haas D, Habiby M, Haino S, Han KC, He ZH, Heil M, Hoffman J, Hsieh TH, Huang ZC, Huh C, Incagli M, Ionica M, Jang WY, Jinchi H, Kanishev K, Kim GN, Kim KS, Kirn T, Kossakowski R, Kounina O, Kounine A, Koutsenko V, Krafczyk MS, La Vacca G, Laudi E, Laurenti G, Lazzizzera I, Lebedev A, Lee HT, Lee SC, Leluc C, Levi G, Li HL, Li JQ, Li Q, Li Q, Li TX, Li W, Li Y, Li ZH, Li ZY, Lim S, Lin CH, Lipari P, Lippert T, Liu D, Liu H, Lolli M, Lomtadze T, Lu MJ, Lu SQ, Lu YS, Luebelsmeyer K, Luo JZ, Lv SS, Majka R, Mañá C, Marín J, Martin T, Martínez G, Masi N, Maurin D, Menchaca-Rocha A, Meng Q, Mo DC, Morescalchi L, Mott P, Müller M, Ni JQ, Nikonov N, Nozzoli F, Nunes P, Obermeier A, Oliva A, Orcinha M, Palmonari F, Palomares C, Paniccia M, Papi A, Pauluzzi M, Pedreschi E, Pensotti S, Pereira R, Picot-Clemente N, Pilo F, Piluso A, Pizzolotto C, Plyaskin V, Pohl M, Poireau V, Postaci E, Putze A, Quadrani L, Qi XM, Qin X, Qu ZY, Räihä T, Rancoita PG, Rapin D, Ricol JS, Rodríguez I, Rosier-Lees S, Rozhkov A, Rozza D, Sagdeev R, Sandweiss J, Saouter P, Sbarra C, Schael S, Schmidt SM, Schulz von Dratzig A, Schwering G, Scolieri G, Seo ES, Shan BS, Shan YH, Shi JY, Shi XY, Shi YM, Siedenburg T, Son D, Spada F, Spinella F, Sun W, Sun WH, Tacconi M, Tang CP, Tang XW, Tang ZC, Tao L, Tescaro D, Ting SC, Ting SM, Tomassetti N, Torsti J, Türkoğlu C, Urban T, Vagelli V, Valente E, Vannini C, Valtonen E, Vaurynovich S, Vecchi M, Velasco M, Vialle JP, Vitale V, Vitillo S, Wang LQ, Wang NH, Wang QL, Wang RS, Wang X, Wang ZX, Weng ZL, Whitman K, Wienkenhöver J, Wu H, Wu X, Xia X, Xie M, Xie S, Xiong RQ, Xin GM, Xu NS, Xu W, Yan Q, Yang J, Yang M, Ye QH, Yi H, Yu YJ, Yu ZQ, Zeissler S, Zhang JH, Zhang MT, Zhang XB, Zhang Z, Zheng ZM, Zhuang HL, Zhukov V, Zichichi A, Zimmermann N, Zuccon P, and Zurbach C
Abstract: A precise measurement of the proton flux in primary cosmic rays with rigidity (momentum/charge) from 1 GV to 1.8 TV is presented based on 300 million events. Knowledge of the rigidity dependence of the proton flux is important in understanding the origin, acceleration, and propagation of cosmic rays. We present the detailed variation with rigidity of the flux spectral index for the first time. The spectral index progressively hardens at high rigidities.
Published: 2015
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45. Highly sensitive detection of a bio-threat pathogen by gold nanoparticle-based oligonucleotide-linked immunosorbent assay.

Author: Seo SH, Lee YR, Ho Jeon J, Hwang YR, Park PG, Ahn DR, Han KC, Rhie GE, and Hong KJ
Subjects: Antibodies, Immobilized chemistry, Biosensing Techniques methods, Enzyme-Linked Immunosorbent Assay, Humans, Sensitivity and Specificity, Tularemia microbiology, Francisella tularensis isolation & purification, Gold chemistry, Immobilized Nucleic Acids chemistry, Immunoassay methods, Immunosorbents chemistry, Metal Nanoparticles chemistry, Tularemia diagnosis
Abstract: Francisella (F.) tularensis causes the zoonotic disease tularemia and categorized as one of the highest-priority biological agents. The sensing approaches utilized by conventional detection methods, including enzyme-linked immunosorbent assay (ELISA), are not sensitive enough to identify an infectious dose of this high-risk pathogen due to its low infective dose. As an attempt to detect F. tularensis with high sensitivity, we utilized the highly sensitive immunoassay system named gold nanoparticle-based oligonucleotide-linked immunosorbent assay (GNP-OLISA) which uses antibody-gold nanoparticles conjugated with DNA strands as a signal generator and RNA oligonucleotides appended with a fluorophore as a quencher for signal amplification. We modified the GNP-OLISA for the detection F. tularensis to utilize one antibody for both the capture of the target and for signal generation instead of using two different antibodies, which are usually employed to construct the antibody sandwich in the ELISA. The GNP-OLISA showed 37-fold higher sensitivity compared with ELISA and generated very consistent detection results in the sera. In addition, the detection specificity was not affected by the presence of non-target bacteria, suggesting that GNP-OLISA can be used as a sensitive detection platform for monitoring high-risk pathogens thereby overcoming the limit of the conventional assay system., (Copyright © 2014 Elsevier B.V. All rights reserved.)
Published: 2015
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46. Allogeneic head and body reconstruction: mouse model.

Author: Ren XP, Song Y, Ye YJ, Li PW, Han KC, Shen ZL, Shan JG, Luther K, and Yang BF
Subjects: Animals, Electrocardiography, Electroencephalography, Mice, Mice, Inbred Strains, Models, Animal, Vital Signs physiology, Head surgery, Plastic Surgery Procedures methods, Transplantation, Homologous methods
Abstract: Aims: There is still no effective way to save a surviving healthy mind when there is critical organ failure in the body. The next frontier in CTA is allo-head and body reconstruction (AHBR), and just as animal models were key in the development of CTA, they will be crucial in establishing the procedures of AHBR for clinical translation., Methods and Results: Our approach, pioneered in mice, involves retaining the donor brain stem and transplanting the recipient head. Our preliminary data in mice support that this allows for retention of breathing and circulatory function. Critical aspects of the current protocol include avoiding cerebral ischemia through cross-circulation (donor to recipient) and retaining the donor brain stem. Successful clinical translation of AHBR will become a milestone of medical history and potentially could save millions of people., Conclusions: This experimental study has confirmed a method to avoid cerebral ischemia during the surgery and solved an important part of the problem of how to accomplish long-term survival after transplantation and preservation of the donor brain stem., (© 2014 John Wiley & Sons Ltd.)
Published: 2014
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47. Precision Measurement of the (e^{+}+e^{-}) Flux in Primary Cosmic Rays from 0.5 GeV to 1 TeV with the Alpha Magnetic Spectrometer on the International Space Station.

Author: Aguilar M, Aisa D, Alpat B, Alvino A, Ambrosi G, Andeen K, Arruda L, Attig N, Azzarello P, Bachlechner A, Barao F, Barrau A, Barrin L, Bartoloni A, Basara L, Battarbee M, Battiston R, Bazo J, Becker U, Behlmann M, Beischer B, Berdugo J, Bertucci B, Bigongiari G, Bindi V, Bizzaglia S, Bizzarri M, Boella G, de Boer W, Bollweg K, Bonnivard V, Borgia B, Borsini S, Boschini MJ, Bourquin M, Burger J, Cadoux F, Cai XD, Capell M, Caroff S, Casaus J, Cascioli V, Castellini G, Cernuda I, Cervelli F, Chae MJ, Chang YH, Chen AI, Chen H, Cheng GM, Chen HS, Cheng L, Chikanian A, Chou HY, Choumilov E, Choutko V, Chung CH, Clark C, Clavero R, Coignet G, Consolandi C, Contin A, Corti C, Coste B, Crispoltoni M, Cui Z, Dai M, Delgado C, Della Torre S, Demirköz MB, Derome L, Di Falco S, Di Masso L, Dimiccoli F, Díaz C, von Doetinchem P, Donnini F, Du WJ, Duranti M, D'Urso D, Eline A, Eppling FJ, Eronen T, Fan YY, Farnesini L, Feng J, Fiandrini E, Fiasson A, Finch E, Fisher P, Galaktionov Y, Gallucci G, García B, García-López R, Gargiulo C, Gast H, Gebauer I, Gervasi M, Ghelfi A, Gillard W, Giovacchini F, Goglov P, Gong J, Goy C, Grabski V, Grandi D, Graziani M, Guandalini C, Guerri I, Guo KH, Habiby M, Haino S, Han KC, He ZH, Heil M, Hoffman J, Hsieh TH, Huang ZC, Huh C, Incagli M, Ionica M, Jang WY, Jinchi H, Kanishev K, Kim GN, Kim KS, Kirn T, Kossakowski R, Kounina O, Kounine A, Koutsenko V, Krafczyk MS, Kunz S, La Vacca G, Laudi E, Laurenti G, Lazzizzera I, Lebedev A, Lee HT, Lee SC, Leluc C, Li HL, Li JQ, Li Q, Li Q, Li TX, Li W, Li Y, Li ZH, Li ZY, Lim S, Lin CH, Lipari P, Lippert T, Liu D, Liu H, Lomtadze T, Lu MJ, Lu YS, Luebelsmeyer K, Luo F, Luo JZ, Lv SS, Majka R, Malinin A, Mañá C, Marín J, Martin T, Martínez G, Masi N, Maurin D, Menchaca-Rocha A, Meng Q, Mo DC, Morescalchi L, Mott P, Müller M, Ni JQ, Nikonov N, Nozzoli F, Nunes P, Obermeier A, Oliva A, Orcinha M, Palmonari F, Palomares C, Paniccia M, Papi A, Pauluzzi M, Pedreschi E, Pensotti S, Pereira R, Pilo F, Piluso A, Pizzolotto C, Plyaskin V, Pohl M, Poireau V, Postaci E, Putze A, Quadrani L, Qi XM, Räihä T, Rancoita PG, Rapin D, Ricol JS, Rodríguez I, Rosier-Lees S, Rozhkov A, Rozza D, Sagdeev R, Sandweiss J, Saouter P, Sbarra C, Schael S, Schmidt SM, Schuckardt D, Schulz von Dratzig A, Schwering G, Scolieri G, Seo ES, Shan BS, Shan YH, Shi JY, Shi XY, Shi YM, Siedenburg T, Son D, Spada F, Spinella F, Sun W, Sun WH, Tacconi M, Tang CP, Tang XW, Tang ZC, Tao L, Tescaro D, Ting SC, Ting SM, Tomassetti N, Torsti J, Türkoğlu C, Urban T, Vagelli V, Valente E, Vannini C, Valtonen E, Vaurynovich S, Vecchi M, Velasco M, Vialle JP, Wang LQ, Wang QL, Wang RS, Wang X, Wang ZX, Weng ZL, Whitman K, Wienkenhöver J, Wu H, Xia X, Xie M, Xie S, Xiong RQ, Xin GM, Xu NS, Xu W, Yan Q, Yang J, Yang M, Ye QH, Yi H, Yu YJ, Yu ZQ, Zeissler S, Zhang JH, Zhang MT, Zhang XB, Zhang Z, Zheng ZM, Zhuang HL, Zhukov V, Zichichi A, Zimmermann N, Zuccon P, and Zurbach C
Abstract: We present a measurement of the cosmic ray (e^{+}+e^{-}) flux in the range 0.5 GeV to 1 TeV based on the analysis of 10.6 million (e^{+}+e^{-}) events collected by AMS. The statistics and the resolution of AMS provide a precision measurement of the flux. The flux is smooth and reveals new and distinct information. Above 30.2 GeV, the flux can be described by a single power law with a spectral index γ=-3.170±0.008(stat+syst)±0.008(energy scale).
Published: 2014
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48. High statistics measurement of the positron fraction in primary cosmic rays of 0.5-500 GeV with the alpha magnetic spectrometer on the international space station.

Author: Accardo L, Aguilar M, Aisa D, Alpat B, Alvino A, Ambrosi G, Andeen K, Arruda L, Attig N, Azzarello P, Bachlechner A, Barao F, Barrau A, Barrin L, Bartoloni A, Basara L, Battarbee M, Battiston R, Bazo J, Becker U, Behlmann M, Beischer B, Berdugo J, Bertucci B, Bigongiari G, Bindi V, Bizzaglia S, Bizzarri M, Boella G, de Boer W, Bollweg K, Bonnivard V, Borgia B, Borsini S, Boschini MJ, Bourquin M, Burger J, Cadoux F, Cai XD, Capell M, Caroff S, Carosi G, Casaus J, Cascioli V, Castellini G, Cernuda I, Cerreta D, Cervelli F, Chae MJ, Chang YH, Chen AI, Chen H, Cheng GM, Chen HS, Cheng L, Chikanian A, Chou HY, Choumilov E, Choutko V, Chung CH, Cindolo F, Clark C, Clavero R, Coignet G, Consolandi C, Contin A, Corti C, Coste B, Cui Z, Dai M, Delgado C, Della Torre S, Demirköz MB, Derome L, Di Falco S, Di Masso L, Dimiccoli F, Díaz C, von Doetinchem P, Du WJ, Duranti M, D'Urso D, Eline A, Eppling FJ, Eronen T, Fan YY, Farnesini L, Feng J, Fiandrini E, Fiasson A, Finch E, Fisher P, Galaktionov Y, Gallucci G, García B, García-López R, Gast H, Gebauer I, Gervasi M, Ghelfi A, Gillard W, Giovacchini F, Goglov P, Gong J, Goy C, Grabski V, Grandi D, Graziani M, Guandalini C, Guerri I, Guo KH, Haas D, Habiby M, Haino S, Han KC, He ZH, Heil M, Henning R, Hoffman J, Hsieh TH, Huang ZC, Huh C, Incagli M, Ionica M, Jang WY, Jinchi H, Kanishev K, Kim GN, Kim KS, Kirn T, Kossakowski R, Kounina O, Kounine A, Koutsenko V, Krafczyk MS, Kunz S, La Vacca G, Laudi E, Laurenti G, Lazzizzera I, Lebedev A, Lee HT, Lee SC, Leluc C, Levi G, Li HL, Li JQ, Li Q, Li Q, Li TX, Li W, Li Y, Li ZH, Li ZY, Lim S, Lin CH, Lipari P, Lippert T, Liu D, Liu H, Lolli M, Lomtadze T, Lu MJ, Lu YS, Luebelsmeyer K, Luo F, Luo JZ, Lv SS, Majka R, Malinin A, Mañá C, Marín J, Martin T, Martínez G, Masi N, Massera F, Maurin D, Menchaca-Rocha A, Meng Q, Mo DC, Monreal B, Morescalchi L, Mott P, Müller M, Ni JQ, Nikonov N, Nozzoli F, Nunes P, Obermeier A, Oliva A, Orcinha M, Palmonari F, Palomares C, Paniccia M, Papi A, Pauluzzi M, Pedreschi E, Pensotti S, Pereira R, Pilastrini R, Pilo F, Piluso A, Pizzolotto C, Plyaskin V, Pohl M, Poireau V, Postaci E, Putze A, Quadrani L, Qi XM, Rancoita PG, Rapin D, Ricol JS, Rodríguez I, Rosier-Lees S, Rossi L, Rozhkov A, Rozza D, Rybka G, Sagdeev R, Sandweiss J, Saouter P, Sbarra C, Schael S, Schmidt SM, Schuckardt D, Schulz von Dratzig A, Schwering G, Scolieri G, Seo ES, Shan BS, Shan YH, Shi JY, Shi XY, Shi YM, Siedenburg T, Son D, Spada F, Spinella F, Sun W, Sun WH, Tacconi M, Tang CP, Tang XW, Tang ZC, Tao L, Tescaro D, Ting SC, Ting SM, Tomassetti N, Torsti J, Türkoğlu C, Urban T, Vagelli V, Valente E, Vannini C, Valtonen E, Vaurynovich S, Vecchi M, Velasco M, Vialle JP, Vitale V, Volpini G, Wang LQ, Wang QL, Wang RS, Wang X, Wang ZX, Weng ZL, Whitman K, Wienkenhöver J, Wu H, Wu KY, Xia X, Xie M, Xie S, Xiong RQ, Xin GM, Xu NS, Xu W, Yan Q, Yang J, Yang M, Ye QH, Yi H, Yu YJ, Yu ZQ, Zeissler S, Zhang JH, Zhang MT, Zhang XB, Zhang Z, Zheng ZM, Zhou F, Zhuang HL, Zhukov V, Zichichi A, Zimmermann N, Zuccon P, and Zurbach C
Abstract: A precision measurement by AMS of the positron fraction in primary cosmic rays in the energy range from 0.5 to 500 GeV based on 10.9 million positron and electron events is presented. This measurement extends the energy range of our previous observation and increases its precision. The new results show, for the first time, that above ∼200 GeV the positron fraction no longer exhibits an increase with energy.
Published: 2014
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49. Electron and positron fluxes in primary cosmic rays measured with the alpha magnetic spectrometer on the international space station.

Author: Aguilar M, Aisa D, Alvino A, Ambrosi G, Andeen K, Arruda L, Attig N, Azzarello P, Bachlechner A, Barao F, Barrau A, Barrin L, Bartoloni A, Basara L, Battarbee M, Battiston R, Bazo J, Becker U, Behlmann M, Beischer B, Berdugo J, Bertucci B, Bigongiari G, Bindi V, Bizzaglia S, Bizzarri M, Boella G, de Boer W, Bollweg K, Bonnivard V, Borgia B, Borsini S, Boschini MJ, Bourquin M, Burger J, Cadoux F, Cai XD, Capell M, Caroff S, Casaus J, Cascioli V, Castellini G, Cernuda I, Cervelli F, Chae MJ, Chang YH, Chen AI, Chen H, Cheng GM, Chen HS, Cheng L, Chikanian A, Chou HY, Choumilov E, Choutko V, Chung CH, Clark C, Clavero R, Coignet G, Consolandi C, Contin A, Corti C, Coste B, Cui Z, Dai M, Delgado C, Della Torre S, Demirköz MB, Derome L, Di Falco S, Di Masso L, Dimiccoli F, Díaz C, von Doetinchem P, Du WJ, Duranti M, D'Urso D, Eline A, Eppling FJ, Eronen T, Fan YY, Farnesini L, Feng J, Fiandrini E, Fiasson A, Finch E, Fisher P, Galaktionov Y, Gallucci G, García B, García-López R, Gast H, Gebauer I, Gervasi M, Ghelfi A, Gillard W, Giovacchini F, Goglov P, Gong J, Goy C, Grabski V, Grandi D, Graziani M, Guandalini C, Guerri I, Guo KH, Habiby M, Haino S, Han KC, He ZH, Heil M, Hoffman J, Hsieh TH, Huang ZC, Huh C, Incagli M, Ionica M, Jang WY, Jinchi H, Kanishev K, Kim GN, Kim KS, Kirn T, Kossakowski R, Kounina O, Kounine A, Koutsenko V, Krafczyk MS, Kunz S, La Vacca G, Laudi E, Laurenti G, Lazzizzera I, Lebedev A, Lee HT, Lee SC, Leluc C, Li HL, Li JQ, Li Q, Li Q, Li TX, Li W, Li Y, Li ZH, Li ZY, Lim S, Lin CH, Lipari P, Lippert T, Liu D, Liu H, Lomtadze T, Lu MJ, Lu YS, Luebelsmeyer K, Luo F, Luo JZ, Lv SS, Majka R, Malinin A, Mañá C, Marín J, Martin T, Martínez G, Masi N, Maurin D, Menchaca-Rocha A, Meng Q, Mo DC, Morescalchi L, Mott P, Müller M, Ni JQ, Nikonov N, Nozzoli F, Nunes P, Obermeier A, Oliva A, Orcinha M, Palmonari F, Palomares C, Paniccia M, Papi A, Pedreschi E, Pensotti S, Pereira R, Pilo F, Piluso A, Pizzolotto C, Plyaskin V, Pohl M, Poireau V, Postaci E, Putze A, Quadrani L, Qi XM, Rancoita PG, Rapin D, Ricol JS, Rodríguez I, Rosier-Lees S, Rozhkov A, Rozza D, Sagdeev R, Sandweiss J, Saouter P, Sbarra C, Schael S, Schmidt SM, Schuckardt D, Schulz von Dratzig A, Schwering G, Scolieri G, Seo ES, Shan BS, Shan YH, Shi JY, Shi XY, Shi YM, Siedenburg T, Son D, Spada F, Spinella F, Sun W, Sun WH, Tacconi M, Tang CP, Tang XW, Tang ZC, Tao L, Tescaro D, Ting SC, Ting SM, Tomassetti N, Torsti J, Türkoğlu C, Urban T, Vagelli V, Valente E, Vannini C, Valtonen E, Vaurynovich S, Vecchi M, Velasco M, Vialle JP, Wang LQ, Wang QL, Wang RS, Wang X, Wang ZX, Weng ZL, Whitman K, Wienkenhöver J, Wu H, Xia X, Xie M, Xie S, Xiong RQ, Xin GM, Xu NS, Xu W, Yan Q, Yang J, Yang M, Ye QH, Yi H, Yu YJ, Yu ZQ, Zeissler S, Zhang JH, Zhang MT, Zhang XB, Zhang Z, Zheng ZM, Zhuang HL, Zhukov V, Zichichi A, Zimmermann N, Zuccon P, and Zurbach C
Abstract: Precision measurements by the Alpha Magnetic Spectrometer on the International Space Station of the primary cosmic-ray electron flux in the range 0.5 to 700 GeV and the positron flux in the range 0.5 to 500 GeV are presented. The electron flux and the positron flux each require a description beyond a single power-law spectrum. Both the electron flux and the positron flux change their behavior at ∼30 GeV but the fluxes are significantly different in their magnitude and energy dependence. Between 20 and 200 GeV the positron spectral index is significantly harder than the electron spectral index. The determination of the differing behavior of the spectral indices versus energy is a new observation and provides important information on the origins of cosmic-ray electrons and positrons.
Published: 2014
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50. Concepts, challenges, and opportunities in allo-head and body reconstruction (AHBR).

Author: Ren XP, Luther K, Haar L, Wu SL, Song Y, Shan JG, Zhao DB, Shen ZL, and Han KC
Subjects: Animals, History, 20th Century, Humans, Mice, Tissue Transplantation history, Transplantation, Homologous history, Head surgery, Plastic Surgery Procedures, Tissue Transplantation methods, Transplantation, Homologous methods
Published: 2014
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