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2. Pro-thrombotic changes associated with exposure to ambient ultrafine particles in patients with chronic obstructive pulmonary disease: roles of lipid peroxidation and systemic inflammation.

Author

Wang, Teng, Chen, Xi, Li, Haonan, Chen, Wu, Xu, Yifan, Zhang, Hanxiyue, Han, Yiqun, Zhang, Lina, Que, Chengli, Gong, Jicheng, Qiu, Xinghua, Zhu, Tong, and Yao, Yuan

Subjects
COPD, Inflammation, Lipid peroxidation, Particulate matter, Platelet activation, Thrombosis, Ultrafine particles, Adult, Humans, Particulate Matter, Chemokine CCL2, Tumor Necrosis Factor-alpha, Air Pollutants, Lipid Peroxidation, Chemokine CCL3, Chemokine CCL4, 12-Hydroxy-5, 8, 10, 14-eicosatetraenoic Acid, Interleukin-8, Air Pollution, Pulmonary Disease, Chronic Obstructive, Inflammation, Biomarkers, Lipoxygenases, Thromboxanes, Environmental Exposure
Abstract

BACKGROUND: Exposure to particulate matter air pollution is associated with an increased risk of cardiovascular mortality in patients with chronic obstructive pulmonary disease (COPD), but the underlying mechanisms are not yet understood. Enhanced platelet and pro-thrombotic activity in COPD patients may explain their increased cardiovascular risk. We aim to explore whether short-term exposure to ambient particulate matter is associated with pro-thrombotic changes in adults with and without COPD, and investigate the underlying biological mechanisms in a longitudinal panel study. Serum concentration of thromboxane (Tx)B2 was measured to reflect platelet and pro-thrombotic activity. Lipoxygenase-mediated lipid peroxidation products (hydroxyeicosatetraenoic acids [HETEs]) and inflammatory biomarkers (interleukins [ILs], monocyte chemoattractant protein-1 [MCP-1], tumour necrosis factor alpha [TNF-α], and macrophage inflammatory proteins [MIPs]) were measured as potential mediating determinants of particle-associated pro-thrombotic changes. RESULTS: 53 COPD and 82 non-COPD individuals were followed-up on a maximum of four visits conducted from August 2016 to September 2017 in Beijing, China. Compared to non-COPD individuals, the association between exposure to ambient ultrafine particles (UFPs) during the 3-8 days preceding clinical visits and the TxB2 serum concentration was significantly stronger in COPD patients. For example, a 103/cm3 increase in the 6-day average UFP level was associated with a 25.4% increase in the TxB2 level in the COPD group but only an 11.2% increase in the non-COPD group. The association in the COPD group remained robust after adjustment for the levels of fine particulate matter and gaseous pollutants. Compared to the non-COPD group, the COPD group also showed greater increases in the serum concentrations of 12-HETE (16.6% vs. 6.5%) and 15-HETE (9.3% vs. 4.5%) per 103/cm3 increase in the 6-day UFP average. The two lipid peroxidation products mediated 35% and 33% of the UFP-associated increase in the TxB2 level of COPD patients. UFP exposure was also associated with the increased levels of IL-8, MCP-1, MIP-1α, MIP-1β, TNF-α, and IL-1β in COPD patients, but these inflammatory biomarkers did not mediate the TxB2 increase. CONCLUSIONS: Short-term exposure to ambient UFPs was associated with a greater pro-thrombotic change among patients with COPD, at least partially driven by lipoxygenase-mediated pathways following exposure. Trial registration ChiCTR1900023692 . Date of registration June 7, 2019, i.e. retrospectively registered.

Published
2022

3. Short-term air pollution and greenness exposures on oxidative stress in urban and peri-urban residents in Beijing: A part of AIRLESS study

Author

Han, Yiqun, Chen, Wu, Chatzidiakou, Lia, Yan, Li, Zhang, Hanbin, Wang, Yanwen, Cai, Yutong, Krause, Anika, Xie, Wuxiang, Fan, Yunfei, Wang, Teng, Chen, Xi, Xue, Tao, Xie, Gaoqiang, Li, Yingruo, Liang, Pengfei, Jin, Aoming, Zhu, Yidan, Luo, Yan, Han, Xueyu, Qiu, Xinghua, Chan, Queenie, Barratt, Ben, Ezzati, Majid, Elliott, Paul, Jones, Rod, Liu, Jing, Wu, Yangfeng, Zhao, Meiping, Zhang, Junfeng, Kelly, Frank J., Zhu, Tong, Qi, Wenhao, Teng, Yanbo, Barratt, Benjamin, Kelly, Frank, and Ji, John S.

Published
2024
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45. Additional file 1 of Automated classification of time-activity-location patterns for improved estimation of personal exposure to air pollution

Author

Chatzidiakou, Lia, Krause, Anika, Kellaway, Mike, Han, Yiqun, Li, Yilin, Martin, Elizabeth, Kelly, Frank J., Zhu, Tong, Barratt, Benjamin, and Jones, Roderic L.

Abstract

Additional file 1: The Personal air pollution monitor and data procedures. A brief description of the PAM sensor platform and data cleaning/feature extraction for the GPS coordinates, accelerometer and microphone readings. Dealing with missing GPS observations. Satellite signal loss in indoor environments is common. This section describes the rule-based algorithm developed to interpolate missing locations. Variables evaluated for mode of transport classification. Description of all PAM variables and extracted variables from spatio-temporal movement analysis used for RF model development. Participant recruitment and feedback. Descriptive summary of participants’ characteristics, recruitment timeline, example of personal exposure feedback and grouping of manual logs into main categories.

Published
2023
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47. Development and validation of a simple and rapid HILIC-MS/MS method for the quantification of low-abundant lysoglycerophospholipids in human plasma

Author

Li, Haonan, primary, Han, Yiqun, additional, Wang, Teng, additional, Chen, Wu, additional, Xu, Yifan, additional, Gao, Ke, additional, Wang, Yanwen, additional, Gong, Jicheng, additional, Li, Weiju, additional, Zhang, Hongyin, additional, Wang, Junxia, additional, Qiu, Xinghua, additional, and Zhu, Tong, additional

Published
2022
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