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Gastric cancer is the most common malignant neoplasm of digestive system. Our country is a high-risk area of gastric cancer and its morbidity and mortality are higher than the world average. Most patients have entered the advanced stage when they were diagnosed with gastric cancer. So most of them need to radiotherapy and chemotherapy after surgery. As the research moves along, gastric cancer patients can get drug targeted therapy through the molecular detection of tumor specimens to realize the personalized treatment. RNA interference (RNAi) technology is widely used for gene function study, and get the rapid development in the study of mammals. siRNA plays a central role in RNAi, which possesses specific inhibits a mRNA, to adjust the different protein abnormal expressions in tumors occur. The study of siRNA will provide a broader space for gastric cancer gene therapy. [ABSTRACT FROM AUTHOR]

We investigated the methods and experiences of an anus-preserving procedure in curative resection of low rectal carcinoma. Eighty-six patients with low rectal carcinoma underwent Dixon's procedure with device assistance. Patients were then observed for the effects of operation. The operation was successful in all patients. Pathologic examination of specimens revealed negative margins. Complications such as anastomotic leakage were found in 7 cases. All patients recovered well. Device assistance may contribute to the successful performance of anus-preserving procedure in low rectal carcinoma. Whether the anus can be preserved or not depends on the accurate measurement of the distal length of the rectum. A meticulous hemostasis and avoidance of tension on the stoma are key measures for avoiding anastomotic leakage.

Objective: To investigate the effects of TNF-alpha, TNF-beta and the acceptor expression about mechanical renal trauma with extraneous ADM., Methods: There were 104 healthy adult plain grade Wistar rat, randomly divided into four groups:8 in the group of control, 32 in the group of trauma, 32 in the group injected ADM before trauma, 32 in the group injected ADM post trauma. The experimental model of rat kidney with mechanical trauma was prepared by striking the area of rat skin reflecting by kidney with free dropping ferrous hammer in the last three groups. ADM (0.1 nmol/kg) administrated by intraperitoneal injection at 10 minutes before trauma or post trauma respectively in injected groups. All rats were executed by drawing-out all the blood in their hearts. Renal tissue was investigated to study positive expression of TNF-alpha, TNF-beta, TNFR after SABC stained., Results: TNF-alpha expression:the TNF-alpha expression of trauma group was more positive than it of control group in the wound early time. The expression of group injected post trauma was less than it of trauma group at 1 h (P < 0.01). The expression of group injected before trauma was less than it of trauma group at 6 h (P < 0.05) TNF-beta expression: the TNF-beta expression of trauma group was less than it of control group at 1 h and 6 h (P < 0.05). The TNF-beta expression of group injected post trauma was more positive than it of trauma group at the same time of 1 h and 6 h (P < 0.01). TNFR expression: the TNFR expression of trauma group was less than it of control group at 6 h (P < 0.01). The TNFR expression of group injected before trauma was more positive than it of trauma group in the at the same time of 1 h and 6 h (P < 0.01)., Conclusions: The TNFR can regulate the TNF-alpha and the TNF-beta in dynamic balancing. The regulation of TNFR is main to TNF-alpha. What the TNF-beta participated in renal trauma mainly is the anti-damage process. ADM can reduce the expression of TNF-alpha. ADM increases the expression of TNF-beta and TNFR.