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365 results on '"Han, Song-Hee"'

4. Characterizing the Tumor Microenvironment and Its Correlation with cDC1‐Related Gene Expression in Gastric Cancer.

Author

Han, Song-Hee, Ju, Mi Ha, and Amdare, Nitin

Subjects
*IMMUNE checkpoint proteins, *PROPORTIONAL hazards models, *GENE expression, *CYTOTOXIC T cells, *TUMOR microenvironment
Abstract

Background and Aim. Gastric cancer (GC) remains a significant global health challenge. The role of conventional type 1 dendritic cells (cDC1s) in the tumor microenvironment and their association with cancer prognosis is gaining attention. This study aims to evaluate the prognostic value of cDC1‐related genes (CD141, XCR1, CLEC9A, CADM1, and BTLA) in GC and explore their underlying biological mechanisms. Materials and Methods. We analyzed RNA‐seq data from the Cancer Genome Atlas (TCGA‐STAD) and Gene Expression Omnibus (GEO) datasets, focusing on five cDC1‐related genes. The cDC1‐related signature was defined and divided into high and low expression groups. We employed gene set variation analysis (GSVA) for oncogenic signaling pathways and conducted comprehensive statistical analyses, including Kaplan–Meier and Cox proportional hazards models. Results. The high cDC1‐related gene signature group was associated with poorer overall and disease‐free survival in the TCGA‐STAD cohort. Significant differences in CD8+ T cell infiltration and cytotoxic capabilities were observed between high and low CDC1‐related signature groups. The study also revealed a strong correlation between CDC1‐related signature and increased expression of immune checkpoint proteins and oncogenic pathways, suggesting a complex immunosuppressive tumor microenvironment. Conclusions. Our findings indicate the potential of the cDC1‐related signature as a prognostic marker in GC, offering insights into the tumor–immune interplay. The study underscores the importance of cDC1s in shaping the tumor microenvironment and their influence on patient prognosis in GC. These results may contribute to the development of novel therapeutic strategies targeting the immune microenvironment in GC. [ABSTRACT FROM AUTHOR]

Published
2024
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18. A Simple Laser-Induced Breakdown Spectroscopy Method for Quantification and Classification of Edible Sea Salts Assisted by Surface-Hydrophilicity-Enhanced Silicon Wafer Substrates.

Author

Choi, Han-Bum, Moon, Seung-Hyun, Kim, Hyang, Guthikonda, Nagaraju, Ham, Kyung-Sik, Han, Song-Hee, Nam, Sang-Ho, and Lee, Yong-Hoon

Subjects
SEA salt, SILICON wafers, LASER-induced breakdown spectroscopy, FOOD additives, SALT crystals, SEMICONDUCTOR lasers, SOLID-state lasers, SILICON solar cells
Abstract

Salt, one of the most commonly consumed food additives worldwide, is produced in many countries. The chemical composition of edible salts is essential information for quality assessment and origin distinction. In this work, a simple laser-induced breakdown spectroscopy instrument was assembled with a diode-pumped solid-state laser and a miniature spectrometer. Its performances in analyzing Mg and Ca in six popular edible sea salts consumed in South Korea and classification of the products were investigated. Each salt was dissolved in water and a tiny amount of the solution was dropped and dried on the hydrophilicity-enhanced silicon wafer substrate, providing homogeneous distribution of salt crystals. Strong Mg II and Ca II emissions were chosen for both quantification and classification. Calibration curves could be constructed with limits-of-detection of 87 mg/kg for Mg and 45 mg/kg for Ca. Also, the Mg II and Ca II emission peak intensities were used in a k-nearest neighbors model providing 98.6% classification accuracy. In both quantification and classification, intensity normalization using a Na I emission line as a reference signal was effective. A concept of interclass distance was introduced, and the increase in the classification accuracy due to the intensity normalization was rationalized based on it. Our methodology will be useful for analyzing major mineral nutrients in various food materials in liquid phase or soluble in water, including salts. [ABSTRACT FROM AUTHOR]

Published
2023
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22. Supplemental Material - Feasibility of a Low-Power, Low-Resolution Laser-Induced Breakdown Spectroscopy Instrument for Analysis of Nickel Alloys: Quantification of the Major Alloying Elements and Classification

Author

Choi, Hanbum, Kim, Hyang, Han, Song-Hee, Kim, Sunhye, Jung, Sehoon, Nam, Sang-Ho, and Lee, Yonghoon

Subjects
FOS: Other engineering and technologies, 99999 Engineering not elsewhere classified
Abstract

Supplemental Material for Feasibility of a Low-Power, Low-Resolution Laser-Induced Breakdown Spectroscopy Instrument for Analysis of Nickel Alloys: Quantification of the Major Alloying Elements and Classification by Hanbum Choi, Hyang Kim, Song-Hee Han, Sunhye Kim, Sehoon Jung, Sang-Ho Nam and Yonghoon Lee in Applied Spectroscopy

Published
2023
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