Search

Shaoguang Li,1 Zhan Lin,1 Haobo Chen,1 Qiu Luo,1 Shengnan Han,1 Kunlong Huang,1 Ruichan Chen,1 Yuying Zhan,1 Bing Chen,2 Hong Yao1– 3 1Department of Pharmaceutical Analysis, School of Pharmacy, Fujian Medical University, Fuzhou, FuJian, People’s Republic of China; 2Higher Educational Key Laboratory for Nano Biomedical Technology of Fujian Province, Fujian Medical University, Fuzhou, Fujian, People’s Republic of China; 3Fujian Key Laboratory of Drug Target Discovery and Structural and Functional Research, Fujian Medical University, Fuzhou, Fujian, People’s Republic of ChinaCorrespondence: Shaoguang Li; Hong Yao, Department of Pharmaceutical Analysis, School of Pharmacy, Fujian Medical University, 1 Xue Yuan Road, University Town, Fuzhou, Fujian, 350122, People’s Republic of China, Email lsg941@126.com; yauhung@126.comBackground: The preclinical diagnosis of tumors is of great significance to cancer treatment. Near-infrared fluorescence imaging technology is promising for the in-situ detection of tumors with high sensitivity.Methods: Here, a fluorescent probe was synthesized on the basis of Au nanoclusters with near-infrared light emission and applied to fluorescent cancer cell labeling. Near-infrared methionine-N-Hydroxy succinimide Au nanoclusters (Met-NHs-AuNCs) were prepared successfully by one-pot synthesis using Au nanoclusters, methionine, and N-Hydroxy succinimide as frameworks, reductants, and stabilizers, respectively. The specific fluorescence imaging of tumor cells or tissues by fluorescent probe was studied on the basis of SYBYL Surflex-DOCK simulation model of LAT1 active site of overexpressed receptor on cancer cell surface. The results showed that Met-NHs-AuNCs interacted with the surface of LAT1, and C_Score scored the conformation of the probe and LAT1 as five.Results: Characterization and in vitro experiments were conducted to explore the Met-NHs-AuNCs targeted uptake of cancer cells. The prepared near-infrared fluorescent probe (Met-NHs-A

Public organizations are adopting Robotic Process Automation (RPA) to enhance process performance. However, there is a lack of knowledge regarding how RPA specifically advances routine practices in public organizations, particularly in developing countries. To address this research gap, we conducted an interpretive case study in Turkey, focusing on the implementation of RPA from the perspective of technology as routine capability. Our findings reveal that the case organization has advanced its practices by leveraging RPA affordances, implementing effective governance mechanisms, and developing automation capabilities. This research contributes unique contextual insights into the implementation of RPA within a public organization situated in a developing country. The empirical evidence demonstrates the transformative impact of RPA on organizational practices and provides guidance for optimizing RPA governance practices and sustaining RPA-enabled automation capabilities. This study offers practical implications for public organizations aiming to leverage RPA as part of their broader digital transformation initiatives., Paper Number 1679; Track General; Complete Paper.

Privacy is one of the key challenges to the adoption and implementation of online proctoring systems (OPS) in higher education. To better understand this challenge, we adopt privacy as contextual integrity theory to conduct a scoping review of 17 papers. The results show different types of students’ personal and sensitive information are collected and disseminated; this raises considerable privacy concerns. As well as the governing principles including transparency and fairness, consent and choice, information minimization, accountability, and information security and accuracy have been identified to address privacy problems. This study notifies a need to clarify how these principles should be implemented and sustained, and what privacy concerns and actors they relate to. Further, it calls for the need to clarify the responsibility of key actors in enacting and sustaining responsible adoption and use of OPS in higher education.