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6. IC‐P‐099: ASSOCIATION OF LONG‐TERM EXPOSURE TO AIR PARTICULATE MATTER WITH CEREBRAL AMYLOID DEPOSITION AND GRAY MATTER CHANGES IN COGNITIVELY NORMAL OLDER ADULTS

Author

Lee, Jun Ho, primary, Byun, Min Soo, additional, Yi, Dahyun, additional, Ko, Kang, additional, Jeon, So Yeon, additional, Kim, Woo Jin, additional, Sohn, Bo Kyung, additional, Kim, Jee Wook, additional, Lee, Jun-Young, additional, Han, Myeong-Il, additional, Lee, Younghwa, additional, Joung, Haejung, additional, and Lee, Dong Young, additional

Published
2018
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7. O4‐07‐05: ASSOCIATION OF LONG‐TERM EXPOSURE TO AIR PARTICULATE MATTER WITH CEREBRAL AMYLOID DEPOSITION AND GRAY MATTER CHANGES IN COGNITIVELY NORMAL OLDER ADULTS

Author

Lee, Jun Ho, primary, Byun, Min Soo, additional, Yi, Dahyun, additional, Ko, Kang, additional, Jeon, So Yeon, additional, Kim, Woo Jin, additional, Sohn, Bo Kyung, additional, Kim, Jee Wook, additional, Lee, Jun-Young, additional, Han, Myeong-Il, additional, Lee, Younghwa, additional, Joung, Haejung, additional, and Lee, Dong Young, additional

Published
2018
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13. [P3-410]: ASSOCIATION OF PAST AND CURRENT BODY MASS INDEX WITH BRAIN AMYLOID DEPOSITION AND NEURODEGENERATION IN COGNITIVELY NORMAL ELDERLY

Author

Lee, Seung Hoon, primary, Byun, Min Soo, additional, Lee, Jun Ho, additional, Yi, Dahyun, additional, Sohn, Bo Kyung, additional, Lee, Jun-Young, additional, Choe, Young Min, additional, Choi, Hyo Jung, additional, Baek, Hyewon, additional, Kim, Hyun Jung, additional, Han, Myeong-il, additional, and Lee, Dong Young, additional

Published
2017
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21. Multicenter, randomized, placebo‐controlled, double‐blind clinical trial of escitalopram on the progression‐delaying effects in Alzheimer's disease

Author

Choe, Young Min, primary, Kim, Ki Woong, additional, Jhoo, Jin Hyeong, additional, Ryu, Seung Ho, additional, Seo, Eun Hyun, additional, Sohn, Bo Kyung, additional, Byun, Min Soo, additional, Bak, Jae‐Hwa, additional, Lee, Jong‐Min, additional, Yun, Hyuk Jin, additional, Han, Myeong‐il, additional, Woo, Jong Inn, additional, and Lee, Dong Young, additional

Published
2015
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25. Multicenter, randomized, placebo-controlled, double-blind clinical trial of escitalopram on the progression-delaying effects in Alzheimer's disease.

Author

Choe, Young Min, Kim, Ki Woong, Jhoo, Jin Hyeong, Ryu, Seung Ho, Seo, Eun Hyun, Sohn, Bo Kyung, Byun, Min Soo, Bak, Jae‐Hwa, Lee, Jong‐Min, Yun, Hyuk Jin, Han, Myeong‐il, Woo, Jong Inn, and Lee, Dong Young

Subjects
ALZHEIMER'S disease treatment, CLINICAL trials, SEROTONIN uptake inhibitors, DISEASE progression, DEMENTIA, CITALOPRAM, ALZHEIMER'S disease, BRAIN, COGNITION, COMPARATIVE studies, HIPPOCAMPUS (Brain), MAGNETIC resonance imaging, NEUROPSYCHOLOGICAL tests, RESEARCH methodology, MEDICAL cooperation, PSYCHOLOGICAL tests, RESEARCH, STATISTICAL sampling, EVALUATION research, RANDOMIZED controlled trials, BLIND experiment, NEUROPROTECTIVE agents, PHARMACODYNAMICS, SECOND-generation antidepressants, THERAPEUTICS, PSYCHOLOGY
Abstract

Objectives: A series of preclinical studies have suggested that selective serotonin reuptake inhibitor antidepressants not only stimulate neurogenesis but also have neuroprotective effects. The present study primarily aimed to investigate whether escitalopram would decelerate the brain atrophy of patients with mild-to-moderate Alzheimer's disease (AD). We also assessed the effects of escitalopram on the cognitive function and neuropsychiatric symptoms of these participants.Methods: Seventy-four probable AD patients without major depression were recruited from four dementia clinics of university hospitals and randomly assigned in a 1:1 ratio. Each group received 20 mg/day of escitalopram or placebo for 52 weeks. The primary outcome measures were the change rates of hippocampal and whole brain volume on magnetic resonance imaging for 52 weeks. The Alzheimer's Disease Assessment Scale-cognitive subscale, Mini-Mental State Examination, Neuropsychiatric Inventory, and Cornell Scale for Depression in Dementia (CSDD) were also applied.Results: We did not find any significant differences in the changes of hippocampal or whole brain volume between the groups. Escitalopram showed significant beneficial effects on the CSDD score at 28 weeks compared with placebo (t = -2.17, df = 50.42, p = 0.035), but this finding did not persist throughout the study.Conclusion: The findings of the present study do not support the role of escitalopram as a progression-delaying treatment for AD. However, the negative results of the present trial should be interpreted cautiously because of the relatively small sample size. Further large-scale escitalopram trials targeting the earlier stages of AD, even prodromal AD, are still needed. Copyright © 2015 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

Published
2016
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29. Predictors of suicidal ideation in older individuals receiving home-care services.

Author

Park, Jong-Il, Han, Myeong-il, Kim, Myung Sig, Yoon, Myeong-Sook, Ko, Sung-Hee, Cho, Hye-Chung, and Chung, Young-Chul

Subjects
*GERIATRIC psychiatry, *SUICIDAL ideation, *HOME care services, *SOCIAL support, *DEPRESSION in old age, *SCALING (Social sciences), *SOCIAL networks
Abstract

Objectives Despite the importance of tending to older individuals who are vulnerable to suicide, little is known about suicidal ideation in the portion of this population receiving home-care services in Asian countries. The objective of this cross-sectional study was to examine predictors of suicidal ideation in older individuals using home-care service. Method Participants were randomly selected from the individuals 50 years old and over using home-care services across Jeollabuk-do Province, Korea. A total of 697 subjects participated in this study. Each participant completed the short version of the Geriatric Depression Scale, the Scale for Suicidal Ideation, the Multidimensional Scale of Perceived Social Support, and the World Health Organization Disability Assessment Schedule II. Results Hierarchical regression analyses revealed that depression, perceived social support, and disability were significant predictors of suicidal ideation, whereas the roles of subjective health status and fish consumption remained ambiguous in this regard. In terms of social support, we also found that less perceived social support from family members was related to higher levels of suicidal ideation. The associations between various categories of disability and suicidal ideation disappeared after controlling for depression. Our investigation of the mediating effect of depression on the relationship between disability and suicidal ideation revealed that depression was either a complete (disability related to cognition, self-care, getting along with others, and life activities) or partial (disability related to participation) mediator. Conclusions Preventive strategies focusing on depression, social support, and disability should be emphasized during encounters with older people receiving home-care services. Copyright © 2013 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

Published
2014
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