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13. Puerarin inhibits NHE1 activity by interfering with the p38 pathway and attenuates mitochondrial damage induced by myocardial calcium overload in heart failure rats

Author

Pan Guopin, Cui Baoyue, Han Mingming, Lin Laibiao, Li Yinlan, Wang Ling, Guo Shuang, Yin Yaling, Zhan Heqin, and Li Peng

Subjects
puerarin, p38 pathway, NHE1, heart failure, TGF-β, proinflammatory cytokines, Biochemistry, QD415-436, Genetics, QH426-470
Abstract

Previous studies have shown that puerarin plays a key role in protecting humans and animals from cardiovascular diseases. The exact mechanism of the therapeutic effect of puerarin on various cardiovascular diseases (protective effect on cardiomyocytes) is still unclear. In the present study, we identify the role of puerarin in an animal model of experimental heart failure (HF) and explore its underlying mechanisms. The HF rat model is induced by intraperitoneal injection of adriamycin (ADR), and puerarin is administered intragastrically at low, medium, and high concentrations. We demonstrate that puerarin significantly improves myocardial fibrosis and inflammatory infiltration and, as a result, improves cardiac function in ADR-induced HF rats. Mechanistically, we find for the first time that puerarin inhibits overactivated Na+/H+ exchange isoform 1 (NHE1) in HF, which may improve HF by decreasing Na+ and Ca2+ ion concentrations and attenuating mitochondrial damage caused by calcium overload; on the other hand, puerarin inhibits the activation of the p38 pathway in HF, reduces the expressions of TGF-β and proinflammatory cytokines, and suppresses myocardial fibrosis. In conclusion, our results suggest that Puerarin is an effective drug against HF and may play a protective role in the myocardium by inhibiting the activation of p38 and its downstream NHE1.

Published
2024
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46. Discussion on the latest surface ruptures near the Zhonggu village along the Selaha segment of the Xianshuihe fault zone

Author

HAN Mingming, CHEN Lichun, ZENG Di, LI Yanbao, LIANG Mingjian, GAO Shuaipo, WANG Dongbing, and LUO Liang

Subjects
the xianshuihe fault, the selaha segment, earthquake-induced surface rupture, trench, the 2014 kangding ms6.3 earthquake, Geology, QE1-996.5
Abstract

The Selaha segment of the Xianshuihe fault zone was the seismogenic fault of the 2014 Kangding MS 6.3 earthquake. This segment has been considered as one of the most dangerous areas for surface rupture-induced earthquakes with a magnitude of M≥7 due to the long elapsed time of the latest surface rupture event (the 1725 Kangding MS7.0 earthquake). Obtaining the spatial distribution of the latest seismic surface rupture along the Selaha fault is significant for determining the seismic activity history, assessing the seismic potential, and preventing and mitigating disasters. However, there is still considerable controversy about the extension northwestern of the latest surface rupture. In order to solve this problem, we excavated two large paleoseismic trenches in the Zhonggu village where the previous data believed that there was no coseismic surface rupture, and obtained the rupture history of this region. The latest event (E6) occurred after A.D.746±51. Based on the trench profile evidence, geomorphological features, and historical earthquake records, the latest event E6 is associated with the 1725 Kangding MS7.0 earthquake, indicating that the surface rupture of the event E6 has extended to at least the Zhonggu village.

Published
2022
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