12,158 results on '"Han, Liu"'
Search Results
2. Energy Evolution and Brittleness Analysis of Sandstone Under Confining Pressure Unloading
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Li, Yinda, Han, Liu, and Shang, Tao
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- 2024
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3. Risk factors for positive resection margins after endoscopic resection for gastrointestinal neuroendocrine tumors
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Han, Liu, Li, Jianglei, Liang, Chengbai, Chu, Yi, Wang, Yongjun, Lv, Liang, Liu, Deliang, and Tan, Yuyong
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- 2024
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4. Molecular understanding and clinical aspects of tumor-associated macrophages in the immunotherapy of renal cell carcinoma
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Han Liu, Zongwei Lv, Gong Zhang, Zhenhong Yan, Song Bai, Dan Dong, and Kefeng Wang
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Immunotherapy ,Renal cell carcinoma ,Tumor-associated macrophages ,Tumor microenvironment ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Renal cell carcinoma (RCC) is one of the most common tumors that afflicts the urinary system, accounting for 90–95% of kidney cancer cases. Although its incidence has increased over the past decades, its pathogenesis is still unclear. Tumor-associated macrophages (TAMs) are the most prominent immune cells in the tumor microenvironment (TME), comprising more than 50% of the tumor volume. By interacting with cancer cells, TAMs can be polarized into two distinct phenotypes, M1-type and M2-type TAMs. In the TME, M2-type TAMs, which are known to promote tumorigenesis, are more abundant than M1-type TAMs, which are known to suppress tumor growth. This ratio of M1 to M2 TAMs can create an immunosuppressive environment that contributes to tumor cell progression and survival. This review focused on the role of TAMs in RCC, including their polarization, impacts on tumor proliferation, angiogenesis, invasion, migration, drug resistance, and immunosuppression. In addition, we discussed the potential of targeting TAMs for clinical therapy in RCC. A deeper understanding of the molecular biology of TAMs is essential for exploring innovative therapeutic strategies for the treatment of RCC.
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- 2024
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5. Comprehensive analysis of clinical data and radiomic features from contrast enhanced CT for differentiating benign and malignant pancreatic intraductal papillary mucinous neoplasms
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Fengxiang Lou, Mingyang Li, Tongjia Chu, Haoyu Duan, Huan Liu, Jian Zhang, Kehang Duan, Han Liu, and Feng Wei
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Medicine ,Science - Abstract
Abstract The primary aim of this investigation was to leverage radiomics features derived from contrast-enhanced abdominal computed tomography (CT) scans to devise a predictive model to discern the benign and malignant nature of intraductal papillary mucinous neoplasms (IPMNs). Radiomic signatures were meticulously crafted to delineate benign from malignant IPMNs by extracting pertinent features from contrast-enhanced CT images within a designated training cohort (n = 84). Subsequent validation was conducted with data from an independent test cohort (n = 37). The discriminative ability of the model was quantitatively evaluated through receiver operating characteristic (ROC) curve analysis, with the integration of carefully selected clinical features to improve the comparative analysis. Arterial-phase images were utilized to construct a model comprising 8 features for distinguishing between benign and malignant cases. The model achieved an accuracy of 0.891 [95% confidence interval (95% CI), 0.816–0.996] in the cross-validation set and 0.553 (95% CI 0.360–0.745) in the test set. Conversely, employing 9 features from the venous-phase resulted in a model with a cross-validation accuracy of 0.862 (95%CI 0.777–0.946) and a test set accuracy of 0.801 (95% CI 0.653–0.950).Integrating the identified clinical features with imaging features yielded a model with a cross-validation accuracy of 0.934 (95% CI 0.879–0.990) and a test set accuracy of 0.904 (95% CI 0.808–0.999), thereby further improving its discriminatory ability. Our findings distinctly illustrate that venous-phase radiomics features eclipse arterial-phase radiomic features in terms of predictive accuracy regarding the nature of IPMNs. Furthermore, the synthesis and meticulous screening of clinical features with radiomic data significantly increased the diagnostic efficacy of our model, underscoring the pivotal importance of a comprehensive and integrated approach for accurate risk stratification in IPMN management.
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- 2024
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6. Topical treatment and care of 17 cases of severe alopecia areata treated with topical diphenylcyclopropenone
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Rong TANG, Yufang ZENG, Xiuyun HUANG, Miao QU, Tingting LI, Zhihui LIU, Han LIU, and Ying LUO
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alopecia areata ,diphenylcyclopropenone ,local immunotherapy ,nursing ,Dermatology ,RL1-803 - Abstract
Objective To summarize the experience of nursing care of patients with severe alopecia areata treated with topical diphenylcyclopropenone. Methods Seventeen patients with severe alopecia areata treated with topical diphenylcyclopropenone were enrolled. Before the treatment, self-protection was given to the therapist and informed consent was given to the patients. During the treatment, the principles of procedure and drug dosages were strictly followed. After the treatment, WeChat APP was used in the follow-up management of patients. This management included one-to-one evaluation of and consultation on efficacy, adverse reactions, diet and psychology. Results Seventeen patients completed the 16-week treatments, with an effective rate of 58.82%. The adverse reactions were mild and controllable. The therapists did not experience any adverse reactions such as allergic reactions. Conclusion In the treatment of severe alopecia areata with topical diphenylcyclopropenone, appropriate pre-operative preparation and post-operative care can effectively improve the patient's compliance and the therapeutic efficacy.
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- 2024
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7. Sleep promoting and omics exploration on probiotics fermented Gastrodia elata Blume
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Chao-Qi Zhang, Xu-Dong Zhang, Yan Wang, Yi-Han Liu, Cun-Li Zhang, and Qiang Zhang
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Nutrition. Foods and food supply ,TX341-641 ,Food processing and manufacture ,TP368-456 - Abstract
Abstract Fermenting Chinese medicinal herbs could enhance their bioactivities. We hypothesized probiotic-fermented gastrodia elata Blume (GE) with better potential to alleviate insomnia than that of unfermented, thus the changes in chemical composition and the insomnia-alleviating effects and mechanisms of fermented GE on pentylenetetrazole (PTZ)-induced insomnia zebrafish were explored via high-performance liquid chromatography (HPLC) and mass spectroscopy-coupled HPLC (HPLC-MS), phenotypic, transcriptomic, and metabolomics analysis. The results demonstrated that probiotic fermented GE performed better than unfermented GE in increasing the content of chemical composition, reducing the displacement, average speed, and number of apoptotic cells in zebrafish with insomnia. Metabolomic investigation showed that the anti-insomnia effect was related to regulating the pathways of actin cytoskeleton and neuroactive ligand-receptor interactions. Transcriptomic and reverse transcription qPCR (RT-qPCR) analysis revealed that secondary fermentation liquid (SFL) significantly modulated the expression levels of neurod1, msh2, msh3, recql4, ercc5, rad5lc, and rev3l, which are mainly involved in neuron differentiation and DNA repair. Collectively, as a functional food, fermented GE possessed potential for insomnia alleviation.
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- 2024
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8. Stepping forward: T-cell redirecting bispecific antibodies in cancer therapy
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Xiaojing Qin, Wenjing Ning, Han Liu, Xue Liu, Wenxin Luo, and Ningshao Xia
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Bispecific antibody (BsAbs) ,T-cell redirecting BsAbs ,Tumor-associated antigens ,Toxicity ,Cytokine release syndrome ,Tumor microenvironment ,Therapeutics. Pharmacology ,RM1-950 - Abstract
T cell-redirecting bispecific antibodies are specifically designed to bind to tumor-associated antigens, thereby engaging with CD3 on the T cell receptor. This linkage between tumor cells and T cells actively triggers T cell activation and initiates targeted killing of the identified tumor cells. These antibodies have emerged as one of the most promising avenues within tumor immunotherapy. However, despite success in treating hematological malignancies, significant advancements in solid tumors have yet to be explored. In this review, we aim to address the critical challenges associated with T cell-redirecting bispecific antibodies and explore novel strategies to overcome these obstacles, with the ultimate goal of expanding the application of this therapy to include solid tumors.
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- 2024
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9. Lagrangian relaxation-based approaches for cooperative location and assignment of emergency responders
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Yang Zhou, Han Liu, Naiyu Wang, and Yu Gu
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Fire Response optimization ,Facility location and assignment problem ,Cooperative responder logistics ,Mixed-integer program ,Lagrangian relaxation ,Engineering (General). Civil engineering (General) ,TA1-2040 - Abstract
Efficient fire response and the coordination of various fire vehicles are paramount for delivering optimal services and conducting effective rescue operations. This study explores the challenges of cooperative station location and vehicle assignment, focusing on the synergistic dispatch of fire vehicles from multiple stations. It highlights that the response time of the last arriving vehicle, crucial for forming a complete and effective response unit, is a critical determinant in the overall success of fire rescue operations. The primary objective of the model is to minimize the total system cost, encompassing both the capital investment in fire stations and the potential losses from fire incidents. By employing a Lagrangian relaxation technique, the model effectively simplifies the optimization challenge into more manageable sub-problems, thereby enhancing solution accuracy. The robustness and flexibility of the model were tested through simulations in a hypothetical network and a real-world scenario, using data from urban fire services. The results demonstrate the model’s scalability and adaptability to different network configurations and operational constraints, showcasing its potential to substantially enhance emergency response efficiency and decision-making in urban fire management. This research makes a significant contribution to emergency response management by providing a validated framework that improves the coordination and effectiveness of fire rescue operations, thereby reducing fire damage and enhancing public safety.
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- 2024
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10. Food odors alter behavioral responses and olfactory receptors expression in grass carp (Ctenopharyngodon idellus)
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Ning Liu, Xin Huang, Dongmei Zhu, Suhua Guan, Weimin Wang, and Han Liu
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Grass carp ,Olfactory receptors ,Behavioral responses ,Food odors ,Aquaculture. Fisheries. Angling ,SH1-691 - Abstract
Olfaction, the sense of smell, is crucial for animal survival, especially in localizing prey or food. However, little is known about the fish behavioral responses to specific food odors and which olfactory receptor might be activated by the food odors. Here, we examined the evolutionary relationships and classified the subfamilies of olfactory receptors (ORs), and conducted behavioral and gene expression analysis in grass carp (Ctenopharyngodon idellus). We identified 196 intact ORs in the grass carp genome and classified them into 8 subfamilies: β, δ, ε, η, γ, κ, θ, and ζ. 12 representative ORs (4 β, 4 δ, and 4 ε) were highly expressed in the olfactory epithelium (OE) of 24-month-old grass carp. Behavioral exploration found that grass carp showed different behaviors to different food odors at a series of concentrations. Specifically, 0.01 μmol/L amino acid mixtures and 0.005 × Hydrilla verticillata extracts strongly changed the preference index and swimming trajectories in 6-month-old grass carp. In addition, the two food odors stimulation differentially induced ORs expression in three tissues, especially strong in the olfactory bulb and brain. Altogether, our results suggest that olfaction plays an important role in the regulation of fish feeding behavior and provide a basis for further studies on the function and specific recognition of olfactory receptors in fish.
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- 2024
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11. Sulfidation of nano zero-valent iron for enhanced hexavalent chromium removal performance
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Xiu-juan Feng, Xiao-yi Wang, Dong-ming Li, Zhi-han Liu, and Yue-long Yan
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S-nZVI ,Cr(VI) removal ,Wastewater ,Sulfidation ,FeS layers ,Cycling stability ,River, lake, and water-supply engineering (General) ,TC401-506 - Abstract
Nano zero-valent iron (nZVI) and sulfidation-modified nZVI (S-nZVI) were synthesized and used to remove hexavalent chromium (Cr(VI)) in wastewater. Characterization of the products showed that the sulfidation process significantly changed the morphology of nZVI, with enhanced crystallinity. The effects of S/Fe ratio, pH value, and reaction temperature on Cr(VI) removal were studied. A S/Fe ratio of 0.5 was the most appropriate parameter, with a removal efficiency of 98% in the condition of pH = 2. The effects of anions (Cl−, NO3−, CO32−, and SO42−) and cations (Ca2+ and Mg2+) on the Cr(VI) removal efficiency were investigated, and the relevant mechanisms were discussed. The Cr(VI) removal efficiency of S-nZVI was significantly greater than that of nZVI, mainly owing to the existence of FeS layers that could protect Fe0 cores and prompt electron transfer. The aging and cycling experiments showed that S-nZVI could maintain its reactivity when facing the corrosion of water, and showed cycling stability. Thus, S-nZVI is an effective and feasible agent for the remediation of Cr(VI)-contained wastewater.
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- 2024
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12. GPTScan: Detecting Logic Vulnerabilities in Smart Contracts by Combining GPT with Program Analysis.
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Yuqiang Sun 0001, Daoyuan Wu, Yue Xue, Han Liu, Haijun Wang, Zhengzi Xu, Xiaofei Xie, and Yang Liu 0003
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- 2024
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13. Audio-LLM: Activating the Capabilities of Large Language Models to Comprehend Audio Data.
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Dongting Li, Chenchong Tang, and Han Liu
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- 2024
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14. Multivariate Time Series Forecasting By Graph Attention Networks With Theoretical Guarantees.
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Zhi Zhang, Weijian Li, and Han Liu
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- 2024
15. Security and Efficient Data Verification Protocol for Distributed Database based on Zero-knowledge Proof.
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Han Liu and Yunxu Bai
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- 2024
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16. Automated Fusion of Multimodal Electronic Health Records for Better Medical Predictions.
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Suhan Cui, Jiaqi Wang 0002, Yuan Zhong, Han Liu 0008, Ting Wang 0006, and Fenglong Ma
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- 2024
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17. Depression Detection via Capsule Networks with Contrastive Learning.
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Han Liu 0008, Changya Li, Xiaotong Zhang 0003, Feng Zhang, Wei Wang 0077, Fenglong Ma, Hongyang Chen, Hong Yu 0005, and Xianchao Zhang 0001
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- 2024
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18. Liberating Seen Classes: Boosting Few-Shot and Zero-Shot Text Classification via Anchor Generation and Classification Reframing.
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Han Liu 0008, Siyang Zhao, Xiaotong Zhang 0003, Feng Zhang, Wei Wang 0077, Fenglong Ma, Hongyang Chen, Hong Yu 0005, and Xianchao Zhang 0001
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- 2024
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19. VQAttack: Transferable Adversarial Attacks on Visual Question Answering via Pre-trained Models.
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Ziyi Yin 0003, Muchao Ye, Tianrong Zhang, Jiaqi Wang 0002, Han Liu 0008, Jinghui Chen, Ting Wang 0006, and Fenglong Ma
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- 2024
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20. A Goal Interaction Graph Planning Framework for Conversational Recommendation.
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Xiaotong Zhang 0003, Xuefang Jia, Han Liu 0008, Xinyue Liu, and Xianchao Zhang 0001
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- 2024
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21. Label Hierarchical Structure-Aware Multi-Label Few-Shot Intent Detection via Prompt Tuning.
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Xiaotong Zhang 0003, Xinyi Li, Han Liu 0008, Xinyue Liu, and Xianchao Zhang 0001
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- 2024
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22. Feasibility Analysis of GGDP System Based on Climate Impact Assessment Model
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Xinyuan, Xiao, Han, Liu, Haowei, Zhang, Jiuyang, Tang, Xianrui, Wang, Bezaeva, Natalia S., Series Editor, Gomes Coe, Heloisa Helena, Series Editor, Nawaz, Muhammad Farrakh, Series Editor, and Chen, Xueming, editor
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- 2024
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23. Research on Application Technology of Virtual Coupling Based on Adaptive Tracking
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Chengbin, Hou, Han, Liu, Hong, Shi Yan, Chenglong, Zheng, Lei, Kang Yuan, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Tan, Kay Chen, Series Editor, Yang, Jianwei, editor, Diao, Lijun, editor, Yao, Dechen, editor, and An, Min, editor
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- 2024
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24. Mechanical Properties of a Tapered Composite Structure in a Movable Aircraft Wing
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Han, Liu, Song, Yao, Li, Yingxu, Lin, Changliang, Wang, Jinliang, Gong, Shaobo, Zhang, Zhen, Chinese Society of Aeronautics and Astronautics, Chaari, Fakher, Series Editor, Gherardini, Francesco, Series Editor, Ivanov, Vitalii, Series Editor, Haddar, Mohamed, Series Editor, Cavas-Martínez, Francisco, Editorial Board Member, di Mare, Francesca, Editorial Board Member, Kwon, Young W., Editorial Board Member, Trojanowska, Justyna, Editorial Board Member, and Xu, Jinyang, Editorial Board Member
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- 2024
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25. Effects of Complex Triaxial Unloading Confining Stress Conditions on the Mechanical Behaviour and Fracture Mechanism of Sandstone
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Li, Yinda, Han, Liu, and Shang, Tao
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- 2024
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26. Review of Jin, Guan, Han, Liu, Neubauer & Pollard (2021): Go Far with Chinese 1st edition
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Tang, Xiaofei, primary
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- 2021
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27. Experimental study on the influence of sandstone gradation on the water storage capacity of a pore-space reservoir in a waste dump of an open-pit coal mine
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Wang, Jingwei, Chen, Shuzhao, Han, Liu, Shang, Tao, Cao, Shouhe, Yang, Guoyu, Chen, Tao, and Li, Yinda
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- 2023
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28. miR-449a disturbs atherosclerotic plaque stability in streptozotocin and high-fat diet-induced diabetic mice by targeting CEACAM1
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Jie Yu, Han Liu, Yu Chen, Ling Wang, Peng Chen, Yue Zhao, Chunxia Ou, Wei Chen, Jie Hu, Yu Wang, and Yan Wang
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MiR-449a ,Plaque stability ,Diabetes mellitus ,Atherosclerosis ,CEACAM1 ,Nutritional diseases. Deficiency diseases ,RC620-627 - Abstract
Abstract Background Emerging evidence indicates carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is involved in the development of atherosclerosis (AS). However, the roles and functions of CEACAM1 in AS remain unknown. Therefore, this study aims to investigate the roles and molecular functions of CEACAM1 in AS. Methods We constructed a diabetes mellitus (DM) + high-fat diet (HFD) mouse model based on the streptozotocin (STZ)-induced apolipoprotein E-knockdown (ApopE−/−) mouse to investigate the roles and regulatory mechanism of miR-449a/CEACAM1 axis. The mRNA expression and protein levels in this study were examined using quantity PCR, western blot, immunofluorescence (IF), enzyme-linked immunosorbent assay (ELISA), and immunohistochemistry (IHC), respectively. And the lipid deposition and collagen content were detected using Oil Red O and Sirius Red staining. Cell apoptosis, migration, invasion, and tuber formation were detected by Annexin-V FITC/PI, wound healing, transwell, and tuber formation assays, respectively. The relationship between miR-449a and CEACAM1 was determined by a dual-luciferase reporter gene assay. Results miR-449a and MMP-9 were upregulated, and CEACAM1 was downregulated in the DM + HFD MOUSE model. Upregulation of CEACAM1 promoted atherosclerotic plaque stability and inhibited inflammation in the DM + HFD mouse model. And miR-449a directly targeted CEACAM1. Besides, miR-449a interacted with CEACAM1 to regulate atherosclerotic plaque stability and inflammation in DM-associated AS mice. In vitro, the rescue experiments showed miR-449a interacted with CEACAM1 to affect apoptosis, migration, invasion, and tuber formation ability in high glucose (HG)-induced HUVECs. Conclusion These results demonstrated that miR-449a promoted plaque instability and inflammation in DM and HFD-induced mice by targeting CEACAM1.
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- 2024
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29. Novel CAR T-cell therapies for relapsed/refractory B-cell malignancies: latest updates from 2023 ASH annual meeting
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Wenjie Zhang, Sumei Li, Jinlan Long, Shufeng Xie, Minghui Wang, Han Liu, and Zhenshu Xu
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CAR T-cell therapy ,Relapsed/refractory B-cell malignancies ,ASH 2023 ,Diseases of the blood and blood-forming organs ,RC633-647.5 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Chimeric antigen receptors (CAR) are engineered fusion proteins that target T-cells to specific surface antigens of tumor cells to generate effective anti-tumor responses. CAR T-cell therapy is playing an increasingly important role in the treatment of relapsed/refractory B-cell malignancies (R/R BCM). Attempting to make CAR T-cells safer and more effective in treating R/R BCM, various novel engineered CAR T-cell agents are currently in the research and development or clinical trial stages. We have summarized here the latest reports on the novel CAR T-cell therapies for R/R BCM presented at the 2023 ASH Annual Meeting as well as the latest updates in related clinical trials.
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- 2024
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30. Geospatial evaluation of radiologic access in Rwanda
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Rui Han Liu, Michael Lindeborg, Isaie Ncogoza, Sabine E. Nyiraneza, Keisha J. Barrera, and David A. Shaye
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Diagnostic imaging ,Geographic mapping ,Health services accessibility ,Radiology ,Rwanda ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Abstract Background Rwanda has aimed to rebuild its health care system since the Rwandan genocide against the Tutsis in 1994, though one of the challenges has been a scarcity of radiologic resources. Objective To assess the location and accessibility of radiologic facilities in Rwanda using geospatial mapping and population-based data. Methods A cross-sectional study was conducted in May 2023 using location and radiologic modality data provided by the Department of Radiology at the University Teaching Hospital of Kigali and the WorldPop database, a publicly available database providing open-access geospatial population data. Radiologic equipment included magnetic resonance (MR), computed tomography (CT), positron emission tomography (PET), radiotherapy, X-ray, mammography, and fluoroscopy machines. Geospatial analysis was performed using ArcGIS Pro 2.8.6 software. Results Fifty-six radiologic facilities were identified, including 5 MR, 7 CT, 1 radiotherapy, 52 X-ray, 5 mammography, 5 fluoroscopy, and 0 PET machines. There were 0.4 MR, 0.5 CT, 0 PET, 0.1 radiotherapy, 3.9 X-ray, 0.4 mammography, and 0.4 fluoroscopy units per 1 million people. Conclusion Rwanda is one of the countries with the lowest radiologic access in East Africa; however, there is evidence of progress, particularly in more advanced diagnostic imaging techniques such as computed tomography and magnetic resonance imaging. Critical relevance statement This study provides a 10-year update on current radiologic resources and access in Rwanda, identifying areas of progress and ongoing scarcity, serving as a guide for future direction of growth. Key points • As Rwanda works on rebuilding its health care system, this study provides an assessment of the current radiologic resources within the country. • There is less than one radiologic unit for every million of the Rwandan population for every imaging modality other than X-ray. • While radiologic access in Rwanda lags behind that of its neighbors, there has been growth focused on advanced imaging modalities and the training of human resources. Graphical Abstract
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- 2024
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31. Single cell analysis reveals the roles and regulatory mechanisms of type-I interferons in Parkinson’s disease
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Pusheng Quan, Xueying Li, Yao Si, Linlin Sun, Fei Fan Ding, Yuwei Fan, Han Liu, Chengqun Wei, Ruihua Li, Xue Zhao, Fan Yang, and Lifen Yao
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Type-I interferons ,Single cell ,Immune ,Transcription factors ,Parkinson’s disease ,Medicine ,Cytology ,QH573-671 - Abstract
Abstract The pathogenesis of Parkinson’s disease (PD) is strongly associated with neuroinflammation, and type I interferons (IFN-I) play a crucial role in regulating immune and inflammatory responses. However, the specific features of IFN in different cell types and the underlying mechanisms of PD have yet to be fully described. In this study, we analyzed the GSE157783 dataset, which includes 39,024 single-cell RNA sequencing results for five PD patients and six healthy controls from the Gene Expression Omnibus database. After cell type annotation, we intersected differentially expressed genes in each cell subcluster with genes collected in The Interferome database to generate an IFN-I-stimulated gene set (ISGs). Based on this gene set, we used the R package AUCell to score each cell, representing the IFN-I activity. Additionally, we performed monocle trajectory analysis, and single-cell regulatory network inference and clustering (SCENIC) to uncover the underlying mechanisms. In silico gene perturbation and subsequent experiments confirm NFATc2 regulation of type I interferon response and neuroinflammation. Our analysis revealed that microglia, endothelial cells, and pericytes exhibited the highest activity of IFN-I. Furthermore, single-cell trajectory detection demonstrated that microglia in the midbrain of PD patients were in a pro-inflammatory activation state, which was validated in the 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD mouse model as well. We identified transcription factors NFATc2, which was significantly up-regulated and involved in the expression of ISGs and activation of microglia in PD. In the 1-Methyl-4-phenylpyridinium (MPP+)-induced BV2 cell model, the suppression of NFATc2 resulted in a reduction in IFN-β levels, impeding the phosphorylation of STAT1, and attenuating the activation of the NF-κB pathway. Furthermore, the downregulation of NFATc2 mitigated the detrimental effects on SH-SY5Y cells co-cultured in conditioned medium. Our study highlights the critical role of microglia in type I interferon responses in PD. Additionally, we identified transcription factors NFATc2 as key regulators of aberrant type I interferon responses and microglial pro-inflammatory activation in PD. These findings provide new insights into the pathogenesis of PD and may have implications for the development of novel therapeutic strategies.
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- 2024
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32. Efficient and Stable Proton Exchange Membrane Water Electrolysis Enabled by Stress Optimization
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Jiawei Liu, Han Liu, Yang Yang, Yongbing Tao, Lanjun Zhao, Shuirong Li, Xiaoliang Fang, Zhiwei Lin, Huakun Wang, Hua Bing Tao, and Nanfeng Zheng
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Chemistry ,QD1-999 - Published
- 2024
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33. Deep learning radiomics based prediction of axillary lymph node metastasis in breast cancer
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Han Liu, Liwen Zou, Nan Xu, Haiyun Shen, Yu Zhang, Peng Wan, Baojie Wen, Xiaojing Zhang, Yuhong He, Luying Gui, and Wentao Kong
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract This study aimed to develop and validate a deep learning radiomics nomogram (DLRN) for the preoperative evaluation of axillary lymph node (ALN) metastasis status in patients with a newly diagnosed unifocal breast cancer. A total of 883 eligible patients with breast cancer who underwent preoperative breast and axillary ultrasound were retrospectively enrolled between April 1, 2016, and June 30, 2022. The training cohort comprised 621 patients from Hospital I; the external validation cohorts comprised 112, 87, and 63 patients from Hospitals II, III, and IV, respectively. A DLR signature was created based on the deep learning and handcrafted features, and the DLRN was then developed based on the signature and four independent clinical parameters. The DLRN exhibited good performance, yielding areas under the receiver operating characteristic curve (AUC) of 0.914, 0.929, and 0.952 in the three external validation cohorts, respectively. Decision curve and calibration curve analyses demonstrated the favorable clinical value and calibration of the nomogram. In addition, the DLRN outperformed five experienced radiologists in all cohorts. This has the potential to guide appropriate management of the axilla in patients with breast cancer, including avoiding overtreatment.
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- 2024
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34. Association between serum 25-hydroxyvitamin D and vitamin D dietary supplementation and risk of all-cause and cardiovascular mortality among adults with hypertension
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Haowen Ye, Yexin Li, Shaomin Liu, Xiaofang Zhang, Huanzhu Liang, Ying Wang, Ruxin Wang, Han Liu, Yun Wen, Chunxia Jing, and Lihong Wang
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Serum 25 (OH)D ,Vitamin D supplementation ,Hypertension ,NHANES ,Mortality ,Nutrition. Foods and food supply ,TX341-641 ,Nutritional diseases. Deficiency diseases ,RC620-627 - Abstract
Abstract Background The relationship between vitamin D status and mortality among adults with hypertension remains unclear. Methods This prospective cohort study involved a sample of 19,500 adults with hypertension who participated in the National Health and Nutrition Examination Survey (NHANES) from 2001 to 2018. We utilized a weighted COX proportional hazard model to assess the association between vitamin D status and mortality. This statistical model calculates hazard ratios (HR) and their corresponding 95% confidence intervals (95% CI). Results The study indicated that lower serum 25(OH)D concentration was associated with an increased risk of all-cause mortality among individuals with hypertension. Specially. Those with concentrations between 25.0 and 49.9 nmol/L (HR = 1.71, 95%CI = 1.22–2.40) and less than 25.0 nmol/L (HR = 1.97, 95%CI = 1.15–3.39) had higher hazard ratios for all-cause mortality. Individuals with hypertension who took vitamin D supplements had a lower risk of all-cause mortality, but not the risk of CVD mortality (HR 0.75, 95%CI 0.54–1.03), compared to those who did not supplement (HR = 0.76, 95%CI = 0.61–0.94). Subgroup analysis further revealed that vitamin D supplementation was associated with a reduced risk of all-cause mortality among individuals without diabetes (HR = 0.65, 95%CI = 0.52–0.81) and individuals without CVD (HR = 0.75, 95%CI = 0.58–0.97), and a decreased risk of CVD mortality among individuals without diabetes (HR = 0.63, 95%CI = 0.45–0.88) and without CVD (HR = 0.61, 95%CI = 0.40–0.92). Furthermore, higher-dose vitamin D supplementation was also associated with a greater reduction in all-cause mortality among hypertensive individuals, and there was the potential synergistic effect of combining normal-dose calcium and vitamin D supplementation, showing a superior effect on mortality compared to low-dose supplementation in adults with hypertension. Conclusions This prospective cohort study demonstrated a significant association between lower serum 25 (OH)D concentration and increased all-cause mortality among adults with hypertension. Furthermore, the study found that vitamin D supplementation had a strong and significantly positive correlation with reduced all-cause and CVD mortality among hypertensive individuals without diabetes or CVD. This positive correlation suggests that vitamin D supplementation could potentially be an effective strategy to reduce the risk of mortality in this specific group of people.
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- 2024
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35. Design and discovery of a highly potent ultralong-acting GLP-1 and glucagon co-agonist for attenuating renal fibrosis
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Qian Zhao, Jiale Dong, Han Liu, Hui Chen, Huan Yu, Shuyin Ye, Shuangjin Yu, Yu Li, Longhui Qiu, Nazi Song, Hongjiao Xu, Qi Liu, Zhiteng Luo, Yuyi Li, Rui Wang, Guodong Chen, and Xianxing Jiang
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GLP-1 receptor ,Glucagon receptor ,Chronic kidney disease ,Diabetic nephropathy ,Kidney fibrosis ,Dual-agonism ,Therapeutics. Pharmacology ,RM1-950 - Abstract
The role of co-agonists of glucagon-like peptide-1 receptor (GLP-1R) and glucagon receptor (GCGR) in chronic kidney disease (CKD) remains unclear. Herein we found that GLP-1R and GCGR expression levels were lower in the kidneys of mice with CKD compared to healthy mice and were correlated with disease severity. Interestingly, GLP-1R or GCGR knockdown aggravated the progression of kidney injury in both diabetic db/db mice and non-diabetic mice undergoing unilateral ureteral obstruction (UUO). Based on the importance of GLP-1R and GCGR in CKD, we reported a novel monomeric peptide, 1907-B, with dual-agonism on both GLP-1R and GCGR. The data confirmed that 1907-B had a longer half-life than long-acting semaglutide in rats or cynomolgus monkeys (∼2–3 fold) and exhibited better therapeutic contribution to CKD than best-in-class monoagonists, semaglutide, or glucagon, in db/db mice and UUO mice. Various lock-of-function models, including selective pharmacological activation and genetic knockdown, confirmed that 1907-B's effects on ameliorating diabetic nephropathy in db/db mice, as well as inhibiting kidney fibrosis in UUO mice, were mediated through GLP-1 and glucagon signaling. These findings highlight that 1907-B, a novel GLP-1R and GCGR co-agonist, exerts multifactorial improvement in kidney injuries and is an effective and promising therapeutic option for CKD treatment.
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- 2024
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36. Short‐term prediction of wind power based on temporal convolutional network and the informer model
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Shuohe Wang, Linhua Chang, Han Liu, Yujian Chang, and Qiang Xue
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forecasting theory ,renewable energy sources ,wind power ,Distribution or transmission of electric power ,TK3001-3521 ,Production of electric energy or power. Powerplants. Central stations ,TK1001-1841 - Abstract
Abstract In this study, a new short‐term wind power prediction model based on a temporal convolutional network (TCN) and the Informer model is proposed to solve the problem of low prediction accuracy caused by large wind speed fluctuations in short‐term prediction. First, an input feature selection method based on the maximum information coefficient is proposed after considering the problem of information interference caused by excessively large input features. A dynamic time planning method is used to select the optimal input step of historical power. Then, the combined forecasting model composed of TCN and the Informer is constructed in accordance with the numerical weather forecast and historical power data. Lastly, the pinball loss function is used to expand the prediction model into a quantile regression model, measure the effect of volatility, quantify the volatility range of prediction, and finally, obtain a deterministic prediction result. The actual measured data of wind farms in the Bohai Sea area are selected for analysis and calculation. The results show that the prediction model proposed in this study achieves better accuracy in deterministic prediction and interval prediction than the traditional model.
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- 2024
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37. Research on Application Technology of Virtual Coupling Based on Adaptive Tracking
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Chengbin, Hou, primary, Han, Liu, additional, Hong, Shi Yan, additional, Chenglong, Zheng, additional, and Lei, Kang Yuan, additional
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- 2024
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38. Mechanical Properties of a Tapered Composite Structure in a Movable Aircraft Wing
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Han, Liu, primary, Song, Yao, additional, Li, Yingxu, additional, Lin, Changliang, additional, Wang, Jinliang, additional, Gong, Shaobo, additional, and Zhang, Zhen, additional
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- 2023
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39. Food odors elicit feeding behavior through the activation of the olfactory system in blunt snout bream (Megalobrama amblycephala)
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Huimin Yang, Ning Liu, Suhua Guan, Zexia Gao, and Han Liu
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Megalobrama amblycephala ,Olfaction ,Electrophysiology ,Behavior ,Herbivorous ,Aquaculture. Fisheries. Angling ,SH1-691 - Abstract
Olfaction plays an important role in the survival and reproduction of various organisms. Aside from being a nutrient, in many fish species, amino acids also function as attractants to induce feeding behaviors. As the herbivorous fish, blunt snout bream (Megalobrama amblycephala) commonly consumes an aquatic plant, Hydrilla verticillata. Here, we studied the effect of food odors on the feeding behavior of blunt snout bream using a mixture of amino acids and H. verticillata extract. The behavioral and electro-olfactogram tests demonstrated that the mixture of amino acids and H. verticillata extract induced an attractive reaction and olfactory response in blunt snout bream, respectively. Through Western blotting and immunohistochemical analyses, we confirmed that ciliated and microvillus neurons are distributed on the olfactory placode. The results of phospho-extracellular regulated protein kinases (pERK) showed that a large number of microvillus and ciliated neurons were activated under the stimulation of 10−5 mol/L amino acid mixture and 0.005× H. verticillata extract. The calcium signal imagery demonstrated that the nerve signals of the olfactory bulb were activated by the food odors. The quantitative real-time PCR (qPCR) analysis revealed significant changes in the expression of representative olfactory receptor genes in the olfactory bulb and brain of blunt snout bream upon stimulation with food odor. Collectively, these results provided evidence and preliminary explanations for the mediating role of olfaction in the feeding behavior of fish.
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- 2024
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40. The histamine receptor H1 acts as an alternative receptor for SARS-CoV-2
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Fei Yu, Xiaoqing Liu, Hailan Ou, Xinyu Li, Ruxin Liu, Xi Lv, Shiqi Xiao, Meilin Hu, Taizhen Liang, Tao Chen, Xuepeng Wei, Zhenglai Zhang, Sen Liu, Han Liu, Yiqiang Zhu, Guangyan Liu, Tianyong Tu, Peiwen Li, Hui Zhang, Ting Pan, and Xiancai Ma
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SARS-CoV-2 ,receptor ,HRH1 ,antihistamine ,spike ,viral entry ,Microbiology ,QR1-502 - Abstract
ABSTRACT Numerous host factors, in addition to human angiotensin-converting enzyme 2 (hACE2), have been identified as coreceptors of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), demonstrating broad viral tropism and diversified druggable potential. We and others have found that antihistamine drugs, particularly histamine receptor H1 (HRH1) antagonists, potently inhibit SARS-CoV-2 infection. In this study, we provided compelling evidence that HRH1 acts as an alternative receptor for SARS-CoV-2 by directly binding to the viral spike protein. HRH1 also synergistically enhanced hACE2-dependent viral entry by interacting with hACE2. Antihistamine drugs effectively prevent viral infection by competitively binding to HRH1, thereby disrupting the interaction between the spike protein and its receptor. Multiple inhibition assays revealed that antihistamine drugs broadly inhibited the infection of various SARS-CoV-2 mutants with an average IC50 of 2.4 µM. The prophylactic function of these drugs was further confirmed by authentic SARS-CoV-2 infection assays and humanized mouse challenge experiments, demonstrating the therapeutic potential of antihistamine drugs for combating coronavirus disease 19.IMPORTANCEIn addition to human angiotensin-converting enzyme 2, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can utilize alternative cofactors to facilitate viral entry. In this study, we discovered that histamine receptor H1 (HRH1) not only functions as an independent receptor for SARS-CoV-2 but also synergistically enhances ACE2-dependent viral entry by directly interacting with ACE2. Further studies have demonstrated that HRH1 facilitates the entry of SARS-CoV-2 by directly binding to the N-terminal domain of the spike protein. Conversely, antihistamine drugs, primarily HRH1 antagonists, can competitively bind to HRH1 and thereby prevent viral entry. These findings revealed that the administration of repurposable antihistamine drugs could be a therapeutic intervention to combat coronavirus disease 19.
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- 2024
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41. First case report of diagnosis of extrapancreatic solid pseudopapillary tumor with SMA invasion in a 47-year-old man: a case report and literature review
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Aijing Zhang, Kaibin Wang, Xiaohan Tian, Shuhai Chen, Jianwei Xu, Han Liu, Lei Wang, and Feng Li
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solid pseudopapillary tumor of the pancreas (SPT) ,pancreatic cancer ,extrapancreatic tumor ,ectopic SPT ,vascular invasion ,Surgery ,RD1-811 - Abstract
BackgroundSolid pseudopapillary tumor of the pancreas (SPT) is a rare low-grade malignant tumor predominantly observed in young women without significant clinical symptoms. While most SPTs occur in the pancreatic region, rare cases have occurred in the retroperitoneum, making the diagnosis of ectopic SPTs difficult.Case presentationHerein, we report a rare case of an extrapancreatic solid SPT with superior mesenteric artery (SMA) involvement in a 47-year-old man together with a literature review to provide context with clinical information, CT and a literature review.ConclusionsThis case may provide a practical approach for the diagnosis of ectopic SPT, especially for patients with vascular invasion.
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- 2024
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42. Rapid detection of human cytomegalovirus by multienzyme isothermal rapid amplification and lateral flow dipsticks
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Ming-hui Liu, Xiaochong Guo, Mao-ling Sun, Jia-lun Li, Shu-han Liu, Yun-zhou Chen, Dong-yi Wang, Lan Wang, Yu-zhang Li, Jun Yao, Yang Li, and Yu-qing Pan
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human milk-acquired cytomegalovirus infection ,multienzyme isothermal rapid amplification ,lateral flow strip ,preterm infants ,rapid detection ,Microbiology ,QR1-502 - Abstract
IntroductionHuman cytomegalovirus (HCMV) is the most common viral infection seen in newborns. The major route of transmission for acquired human cytomegalovirus infection is breast milk from mothers who are HCMV seropositive to the infants. Thus, a rapid, economical, and simple method to perform HCMV test in breast milk is crucial and necessary for preventing acquired HCMV infection, especially in underdeveloped regions with limited laboratory resources.MethodsIn this study, an effective technique for the detection of HCMV was constructed by combining multienzyme isothermal rapid amplification (MIRA) and lateral flow chromatography strip (LFD). Primers for the conserved HCMV sequence UL83 were utilized for MIRA-LFD testing.ResultsOur results showed that the entire MIRA reaction could be completed in 12 minutes at 37°C, and LFD outcomes could be observed visibly after 10 minutes. The detection sensitivity of this method reached 50 copy/μl. Samples of breast milk were examined to compare MIRA-LFD and conventional qPCR. The accuracy of MIRA-LFD was 100%.DiscussionThe straightforward, rapid, economic features of the test can provide the significant advantages for the prevention of breast milk-acquired cytomegalovirus infection, particularly in resource-limited locations with high seroprevalence of cytomegalovirus.
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- 2024
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43. How does digital literacy impact household carbon emissions? Evidence from household survey in China
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Han Liu, Yushu Zhang, and Yingliang Zhang
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Household carbon emissions ,Consumption behavior ,Digital literacy ,Household life cycle ,Government governance ,Ecological risk perception ,Environmental sciences ,GE1-350 ,Technology - Abstract
In the background of rapid development of digital technology, exploring the relationship between residents' digital literacy (DL) and household carbon emissions (HCEs) is of great practical significance for China to achieve the carbon peak carbon neutral goal. Based on the three-period panel data of the China Family Panel Survey (CFPS) 2016-2020, we categorized digital literacy into digital learning, digital socialization, and digital consumption, and explored the impact of digital literacy on HCEs and its mechanisms. We find that digital literacy significantly and positively affects HCEs, while household life cycle, government governance, and ecological risk perception have a negative moderating effect on digital literacy affecting HCEs respectively. We also find that DL has the largest impact coefficient on HCEs from developmental consumption compared to survival and enjoyment consumption, and that DL has a more significant impact on HCEs from the consumption of young and middle-aged residents compared to older residents. These findings suggest that the dissemination of information and knowledge about carbon emissions through digital technologies, such as Internet platforms, can strengthen residents' awareness of environmental protection and thus promote their low-carbon consumption behavior.
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- 2024
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44. Traditional Chinese medicine for post-viral olfactory dysfunction: A systematic review
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Xiang-yun Zou, Xue-han Liu, Chun-li Lu, Xin-yan Jin, Bai-xiang He, Yi-lei Liao, Ting Liu, Yi-dan Dai, Shi-hao Qi, Zhu-jun Sheng, Zhan-feng Yan, Guo-Yan Yang, Trine Stub, and Jian-ping Liu
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Post-viral olfactory dysfunction ,Hyposmia ,Anosmia ,Acupuncture ,Long COVID ,Miscellaneous systems and treatments ,RZ409.7-999 - Abstract
Background: Post-viral olfactory dysfunction (PVOD) is the common symptoms of long COVID, lacking of effective treatments. Traditional Chinese medicine (TCM) is claimed to be effective in treating olfactory dysfunction, but the evidence has not yet been critically appraised. We conducted a systematic review to evaluate the effectiveness and safety of TCM for PVOD. Methods: We searched eight databases to identified clinical controlled studies about TCM for PVOD. The Cochrane risk of bias tools and GRADE were used to evaluate the quality of evidence. Risk ratio (RR), mean differences (MD), and 95 % confidence interval (CI), were used for effect estimation and RevMan 5.4.1 was used for data analysis. Results: Six randomized controlled trials (RCTs) (545 participants), two non-randomized controlled trials (non-RCTs) (112 participants), and one retrospective cohort study (30 participants) were included. The overall quality of included studies was low. Acupuncture (n = 8) and acupoint injection (n = 3) were the mainly used TCM therapies. Five RCTs showed a better effect in TCM group. Four trials used acupuncture, and three trials used acupoint injection. The results of two non-RCTs and one cohort study were not statistically significant. Two trials reported mild to moderate adverse events (pain and brief syncope caused by acupuncture or acupoint injection). Conclusions: Limited evidence focus on acupuncture and acupoint injection for PVOD and suggests that acupuncture and acupoint injection may be effective in improving PVOD. More well-designed trials should focus on acupuncture to confirm the benefit. Protocol registration: The protocol of this review was registered at PROSPERO: CRD42022366776.
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- 2024
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45. Traditional, complementary and integrative medicine for fatigue post COVID-19 infection: A systematic review of randomized controlled trials
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Xiao-ying Chen, Chun-li Lu, Qian-yun Wang, Xing-ru Pan, Yang-yang Zhang, Jia-le Wang, Jun-Ya Liao, Nai-chong Hu, Chen-yang Wang, Bing-jie Duan, Xue-han Liu, Xin-yan Jin, Jennifer Hunter, and Jian-ping Liu
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Post COVID condition ,Chronic fatigue ,Traditional medicine ,Complementary medicine ,Integrative medicine ,Miscellaneous systems and treatments ,RZ409.7-999 - Abstract
Background: Chronic fatigue is a predominant symptom of post COVID-19 condition, or long COVID. We aimed to evaluate the efficacy and safety of Traditional, Complementary and Integrative Medicine (TCIM) for fatigue post COVID-19 infection. Methods: Ten English and Chinese language databases and grey literature were searched up to 12 April 2023 for randomized controlled trials (RCTs). Cochrane “Risk of bias” (RoB) tool was applied. Evidence certainty was assessed using Grading of Recommendations Assessment, Development, and Evaluation (GRADE). Effect estimates were presented as risk ratio (RR) or mean difference (MD) with 95% confidence interval (CI). Results: Thirteen RCTs with 1632 participants were included. One RCT showed that Bufei Huoxue herbal capsules reduced fatigue (n=129, MD -14.90, 95%CI -24.53 to -5.27), one RCT reported that Ludangshen herbal liquid lowered fatigue (n=184, MD -1.90, 95%CI -2.38 to -1.42), and the other one RCT shown that fatigue disappearance rate was higher with Ludangshen herbal liquid (n=184, RR 4.19, 95%CI 2.06 to 8.53). Compared to traditional Chinese medicine rehabilitation (TCM-rahab) alone, one RCT showed that fatigue symptoms were lower following Qingjin Yiqi granules plus TCM-rehab (n=388, MD -0.48, 95%CI -0.50 to -0.46). Due to concerns with RoB and/or imprecision, the certainty in this evidence was low to very low. No serious adverse events was reported. Conclusions: Limited evidence suggests that various TCIM interventions might reduce post COVID-19 fatigue. Larger, high quality RCTs of longer duration are required to confirm these preliminary findings. Study Registration: The protocol of this review has been registered at PROSPERO: CRD42022384136.
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- 2024
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46. Kribiodosis cantonensis Han & Liu & Luo & Tang 2021, sp. n
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Han, Wu, Liu, Jie, Luo, Yifan, and Tang, Hongqu
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Insecta ,Arthropoda ,Diptera ,Kribiodosis cantonensis ,Animalia ,Biodiversity ,Chironomidae ,Kribiodosis ,Taxonomy - Abstract
Kribiodosis cantonensis Tang sp. n. http://zoobank.org/ urn:lsid:zoobank.org:act: 553A60FA-8F26-4810-8A0D-6D93B2623A5C Material examined. Holotype, male. CHINA: Guangdong Province, Guangzhou City, Conghua District, Lyutian Town, Dongkeng Reservoir, 23°53.287′N, 113°55.069′E, alt., 388 m, 23.iii.2015 (emerged 01.iv.2015), H.Q. Tang; paratype, 2 males, 22.iv.2020; 1 female, 27.vi.2020, as previous, light trap, H.Q. Tang. Etymology. From the type locality, Canton, now Guangzhou. Male (n = 2–3) (Fig. 2–4) Total length 3.14–3.63 mm. Wing length 1.55–1.63 mm. Coloration (Figs. 2–3). Thorax generally brown, with light brown humeral area, scutellum, pleurae and preepisternum. Scutal vittae dark brown. Leg generally brown except pale connection areas in femur-tibia knees and tibia-first tarsus joints in all legs (Fig. 3A, C–D). Tarsomere 4 in fore legs with three dark pseudospurs (Figs. 3B, 4B). Abdomen tergite predominately yellow, with brown conjunctive from T I–VII. T VIII and T IX nearly completely brown. T III with a pair of brown spots subapically (Fig. 2D). Gonocoxite and gonostylus yellow (Figs. 2E–F). Head. Antennal flagellomere 1–12, 555 μm; flagellomere 13, 600 μm, apex with two long setae (Fig. 2A), AR 1.08. Palpomere lengths (in μm): 30–35; 35; 120–125; 105–120; 200. Temporals 8–12. Clypeus with 9–10 setae. Thorax (Figs. 2C, 4C). Antepronotals and acrostichals absent, scutum with a prominent scutal tubercle, 15–20 μm high; dorsocentrals 3–4, usually 1 above the humeral area, 1 below the scutal tubercle, and 2 posterior, 2–3 tiny pale pits usually occurred in the middle section. Prealars and supraalars both absent, scutellum with 2 setae. Tiny trans-oval remnants of humeral pits are present. Wing (Fig. 2B). VR 1.29–1.31. Surface without macrochaetae. R without seta; R 1 with 4–5 setae. R 2+3 almost fused with R 1 in the end; R 4+5 with 2–3 setae distally. Squama bare. Legs (Fig. 3). Total length of fore leg 5.10 mm, about 6.5 times as long as the thorax height. Fore tibia with a slender, offset spur, 15–20 μm long (Fig. 4A). Mid and hind tibia with one fused comb, bearing a distal hooked spur, 70–80 μm long. LR 1 2.48; LR 2 0.91; LR 3 1.21. BV 1 2.15; BV 2 2.85; BV 3 2.48. SV 1 1.24; SV 2 2.59; SV 3 1.85. BR 1 3.0; BR 2 2.4; BR 3 2.8 (n = 1). Hypopygium. (Figs. 2E–F; 4D–E). Anal tergite bands well-developed, meeting in the middle, with 1–2 anal median setae. Distal margin with 6–8 setae at each side. Gonocoxite 90–105 μm long, with a longitudinal row of five long setae in the medio-ventral section. Gonostylus 88–98 μm long, inner margin with 6–8 evenly distributed long setae. Superior volsella (Fig. 4F) base without microtrichia, bearing 2–3 inner setae from the tubercle base, distal digitus long and slender, distal gradually attenuated. Inferior volsella slightly bullous distally, with 12–14 setae. HR 1.03–1.07; HV 3.59–3.92. Female (n = 1) (Fig. 5) Total length 2.33 mm. Wing length 1.85 mm. Coloration (Fig. 5A). Similar to male except the abdomen with brown patch, more extensive in anterior 1/5–1/3 of each segment. Tarsomere 4 of fore legs without dark brown pseudospurs. Head. Eyes bare, with clear dorsal extension, separated by 1.3 times their terminal width. Antenna with five flagellomeres (Fig. 5B), each length (in μm): 150, 105, 110, 65, 130; AR 0.31. Palpomere lengths (in μm): 40; 30; 120; 100; N/A (absent). Temporals 6. Clypeus with 16 setae. Thorax. Antepronotals and acrostichals both absent, scutal tubercle present; dorsocentrals 4, usually 2 above the humeral area, 1 below the scutal tubercle, and 1 posterior, 2–3 tiny pale pits usually in the middle and posterior section. Prealars and supraalars both absent, scutellum 2. Larger trans-oval remnants of humeral pits present, 30 μm long and 15 μm wide. Wing. VR 1.30. Surface without macrochaetae. R without seta, R 1 with 9 setae; R 2+3 indistinct, almost fused with R 1 all through the length; R 4+5 with 5–6 setae distally. Squama bare. Legs. Total length of fore leg 6.03 mm, about 8.0 times as long as the thorax height. Fore tibia with a slender spur, 50 μm long. Mid and hind tibia with two fused combs, with a distal–hooked spur, 70–75 μm long. LR 1 3.08; LR 2 1.0; LR 3 no data. BV 1 2.05; BV 2 3.0; BV 3 no data. SV 1 1.03; SV 2 2.42; SV 3 no data. Bristles of legs unmeasurable. Genitalia (Fig. 5C). S VIII without distinct oval depression, with 16–18 setae. Coxosternapodeme V-shaped, fused in the middle. Notum 150 μm long, about three times as long as the rami. Lateral sternite IX with three setae. Dorsomesal lobe prominent, expanded post-medially; ventrolateral lobe reduced into a small strip, hidden below the well-developed dorsomesal lobe. Apodeme lobe without microtrichia. Two spermatheca oval, 70 μm in the long axis. Postgenital plate triangular shaped. Cercus ship-shaped, 80 μm long. Pupa. Possibly under the description of Zavreliella shidai Cao & Tang, 2017 in error (see discussion). Larva. Unknown.
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- 2021
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47. Adaptive-Correlation-Aware Unsupervised Deep Learning for Anomaly Detection in Cyber-Physical Systems.
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Liang Xi, Dehua Miao, Menghan Li, Ruidong Wang, Han Liu, and Xunhua Huang
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- 2024
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48. A reduced peak-to-average power ratio algorithm based on PMI mode in NR.
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Hequn Zhu, Xu Zhao, Dejian Li, Yubo Wang 0002, Yubing Zhang, Zhenghao Li, and Han Liu
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- 2024
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49. COSST: Multi-Organ Segmentation With Partially Labeled Datasets Using Comprehensive Supervisions and Self-Training.
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Han Liu, Zhoubing Xu, Riqiang Gao, Hao Li, Jianing Wang, Guillaume Chabin, Ipek Oguz, and Sasa Grbic
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- 2024
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50. When Deep Learning-Based Soft Sensors Encounter Reliability Challenges: A Practical Knowledge-Guided Adversarial Attack and Its Defense.
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Runyuan Guo, Han Liu 0007, and Ding Liu
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- 2024
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