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210 results on '"Han, Lingfei"'

14. Experimental Study on Intelligent Mineral Recognition Under Microscope Based on Deep Learning

Author

Han, Lingfei, Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, Xu, Zheng, editor, Parizi, Reza M., editor, Loyola-González, Octavio, editor, and Zhang, Xiaolu, editor

Published
2021
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32. Nanozyme-catalyzed cascade reaction enables a highly sensitive detection of live bacteria.

Author

Liao, Xuewei, Tong, Wenjun, Dai, Li, Han, Lingfei, Sun, Hanjun, Liu, Wenyuan, and Wang, Chen

Abstract

The accurate and timely detection of bacteria is critically important for human health as it helps to determine the original source of bacterial infections and prevent disease spread. Herein, gold nanoparticles (AuNPs) were synthesized using polyoxometalates (POMs) as the stabilizing agent. Since AuNPs have glucose oxidase (GOx)-like activity and POMs possess peroxidase (HRP)-like activity, the as-prepared Au@POM nanoparticles have double enzyme-like activities and facilitate cascade reaction. As known, glucose is required as an energy resource during bacterial metabolism, the concentration of glucose decreases with the increase of bacteria content in a system with bacteria and glucose. Therefore, when we use Au@POM nanozymes to trigger the cascade catalysis of glucose and 3,3′,5,5′-tetramethylbenzidine (TMB), the concentration of glucose and bacteria can be sensitively detected using the absorbance intensity at 652 nm in the visible spectrum. As demonstration, S. aureus and E. coli were used as model bacteria. The experimental results show that the present method has a good linear relationship in the bacterial concentration range of 1 to 7.5 × 107 colony-forming units (CFU) mL−1 with a detection limit of 5 CFU mL−1. This study shows a great promise of nanozyme cascade reactions in the construction of biosensors and clinical detections. [ABSTRACT FROM AUTHOR]

Published
2023
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37. Myeloid-derived suppressor cells cross-talk with B10 cells by BAFF/BAFF-R pathway to promote immunosuppression in cervical cancer

Author

Ding Jianyi, Gan Haili, Yin Bo, Yang Meiqin, Huang Baoyou, Hu Haoran, Li Fang, Zheng Qingliang, and Han Lingfei

Subjects
Cancer Research, Oncology, Immunology, Immunology and Allergy
Abstract

Immunosuppression induced by myeloid-derived suppressor cells (MDSCs) is one of the main obstacles to the efficacy of immunotherapy for cervical cancer. Recent studies on the immunosuppressive ability of MDSCs have primarily focused on T cells, but the effect of MDSCs on B cells function is still unclear. In a study of clinical specimens, we found that the accumulation of MDSCs in patients with cervical cancer was accompanied by high expression of B cell activating factor (BAFF) on the surface and high expression of interleukin (IL)-10-producing B cells (B10) in vivo. We found that the absence of BAFF could significantly inhibit tumor growth in a cervical cancer model using BAFF KO mice. Further studies showed that abundant MDSCs in cervical cancer induced B cells to differentiate into B10 cells by regulating BAFF which acted on the BAFF receptor (BAFF-R) of them. In this process, we found that a large amount of IL-10 secreted by B10 cells can activate STAT3 signaling pathway in MDSCs, and then form a positive feedback loop to promote the differentiation of B10 cells. Therefore, this study reveals a new mechanism of BAFF-mediated mutual immune regulation between MDSCs and B cells in the occurrence and development of cervical cancer.

Published
2022

38. Additional file 1 of EIF4A3-regulated circ_0087429 can reverse EMT and inhibit the progression of cervical cancer via miR-5003-3p-dependent upregulation of OGN expression

Author

Yang, Meiqin, Hu, Haoran, Wu, Sufang, Ding, Jianyi, Yin, Bo, Huang, Baoyou, Li, Fang, Guo, Xiaoqing, and Han, Lingfei

Abstract

Additional file 1: Table S1. Primers used in this study. Table S2. Oligonucleotides used in this study. Additional file 2: Fig. S1 The cancer-promoting effect of si-circ_0087429 in cervical cancer can be reversed by the miR-5003-3p inhibitor. SiHa cells were transfected with si-NC, si-circ, si-circ + inhibitor NC or si-circ + miR inhibitor for subsequent detection. a-b. The expression of circ_0087429 and miR-5003-3p in each group was tested by qRT–PCR. c-g. CCK-8, EdU and colony formation assays were used to detect the proliferation ability of each group of cells. Scale bar, 50 μm. h-i. Wound healing assays were used to determine the migration ability of each group of cells. Scale bar, 100 μm. j-k. Transwell invasion assays were used to detect the invasion ability of each group of cells. Scale bar, 50 μm. **p

Published
2022
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44. An albumin-binding dimeric prodrug nanoparticle with long blood circulation and light-triggered drug release for chemo-photodynamic combination therapy against hypoxia-induced metastasis of lung cancer

Author

Luo, Renjie, primary, Zhang, Zhongtao, additional, Han, Lingfei, additional, Xue, Zhen, additional, Zhang, Kexin, additional, Liu, Fulei, additional, Feng, Feng, additional, Xue, Jingwei, additional, Liu, Wenyuan, additional, and Qu, Wei, additional

Published
2021
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50. Correction: Soluble B and T Lymphocyte Attenuator Possesses Antitumor Effects and Facilitates Heat Shock Protein 70 Vaccine-Triggered Antitumor Immunity against a Murine TC-1 Cervical Cancer Model In Vivo

Author

Han, Lingfei, primary, Wang, Wei, additional, Fang, Yong, additional, Feng, Zuohua, additional, Liao, Shujie, additional, Li, Wei, additional, Li, Yan, additional, Li, Chunxiao, additional, Maitituoheti, Mayinuer, additional, Dong, Hong, additional, Lai, Zhiwen, additional, Gao, Qinglei, additional, Xi, Ling, additional, Wu, Mingfu, additional, Wang, Daowen, additional, Zhou, Jianfeng, additional, Meng, Li, additional, Wang, Shixuan, additional, and Ma, Ding, additional

Published
2020
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