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25 results on '"Han, Fengzhen"'

6. Maternal serum neonicotinoids during early-mid pregnancy and congenital heart diseases in offspring: An exploratory study

Author

Qu, Yanji, primary, Li, Adela Jing, additional, Liu, Xiaoqing, additional, Lin, Shao, additional, Bloom, Michael S., additional, Wang, Ximeng, additional, Li, Xiaohong, additional, Wang, Hui, additional, Han, Fengzhen, additional, Gao, Xiangmin, additional, Wu, Yong, additional, Huang, Kaiqin, additional, Zhuang, Jian, additional, Ma, Shengtao, additional, and Chen, Jimei, additional

Published
2023
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9. Maternal Outcomes Among Pregnant Women With Congenital Heart Disease–Associated Pulmonary Hypertension

Author

Zhang, Qian, primary, Zhu, Fang, additional, Shi, Guocheng, additional, Hu, Chen, additional, Zhang, Weituo, additional, Huang, Puzhen, additional, Zhu, Chunfeng, additional, Gu, Hong, additional, Yang, Dong, additional, Li, Qiangqiang, additional, Niu, Yonghua, additional, Chen, Hao, additional, Ma, Ruixiang, additional, Pan, Ziyi, additional, Miao, Huixian, additional, Zhang, Xin, additional, Li, Genxia, additional, Tang, Yabing, additional, Qiao, Guyuan, additional, Yan, Yichen, additional, Zhu, Zhongqun, additional, Zhang, Hao, additional, Han, Fengzhen, additional, Li, Yanna, additional, Lin, Jianhua, additional, and Chen, Huiwen, additional

Published
2023
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12. Using Innovative Machine Learning Methods to Screen and Identify Predictors of Congenital Heart Diseases

Author

Qu, Yanji, primary, Deng, Xinlei, additional, Lin, Shao, additional, Han, Fengzhen, additional, Chang, Howard H., additional, Ou, Yanqiu, additional, Nie, Zhiqiang, additional, Mai, Jinzhuang, additional, Wang, Ximeng, additional, Gao, Xiangmin, additional, Wu, Yong, additional, Chen, Jimei, additional, Zhuang, Jian, additional, Ryan, Ian, additional, and Liu, Xiaoqing, additional

Published
2022
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13. Gestational exposure to perfluoroalkyl substances and congenital heart defects: A nested case-control pilot study

Author

Ou, Yanqiu, primary, Zeng, Xiaowen, additional, Lin, Shao, additional, Bloom, Michael S., additional, Han, Fengzhen, additional, Xiao, Xiaohua, additional, Wang, Hui, additional, Matala, Rosemary, additional, Li, Xiaohong, additional, Qu, Yanji, additional, Nie, Zhiqiang, additional, Dong, Guanghui, additional, and Liu, Xiaoqing, additional

Published
2021
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17. Maternal residential greenness and congenital heart defects in infants: A large case-control study in Southern China

Author

Nie, Zhiqiang, primary, Yang, Boyi, additional, Ou, Yanqiu, additional, Bloom, Michael S., additional, Han, Fengzhen, additional, Qu, Yanji, additional, Nasca, Philip, additional, Matale, Rosemary, additional, Mai, Jinzhuang, additional, Wu, Yong, additional, Gao, Xiangmin, additional, Guo, Yuming, additional, Markevych, Iana, additional, Zou, Yuxuan, additional, Lin, Shao, additional, Dong, Guanghui, additional, and Liu, Xiaoqing, additional

Published
2020
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18. Evaluation of interactive effects between paternal alcohol consumption and paternal socioeconomic status and environmental exposures on congenital heart defects

Author

Nie, Zhiqiang, primary, Qu, Yanji, additional, Han, Fengzhen, additional, Bell, Erin M., additional, Zhuang, Jian, additional, Chen, Jimei, additional, François, Melissa, additional, Lipton, Emily, additional, Matale, Rosemary, additional, Cui, Weilun, additional, Liang, Qianhong, additional, Lu, Xiangzhang, additional, Huang, Huiwen, additional, Lv, Junfeng, additional, Ou, Yanqiu, additional, Mai, Jinzhuang, additional, Wu, Yong, additional, Gao, Xiangmin, additional, Huang, Yating, additional, Lin, Shao, additional, and Liu, Xiaoqing, additional

Published
2020
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19. Weighted gene co‑expression network analysis identifies key genes from extracellular vesicles as potential prognostic biomarkers for congenital pulmonary stenosis

Author

Huang, Zirui, primary, Li, Xiaohong, additional, Qiu, Min, additional, Chen, Jing, additional, Tian, Miao, additional, Han, Fengzhen, additional, Ou, Yanqiu, additional, Liu, Xiaoqing, additional, Zhou, Chengbin, additional, Yuan, Haiyun, additional, Zhuang, Jian, additional, and Chen, Jimei, additional

Published
2020
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22. Perinatal and early postnatal outcomes for fetuses with prenatally diagnosed d-transposition of the great arteries: a prospective cohort study assessing the effect of standardised prenatal consultation

Author

Qu, Yanji, primary, Wen, Shusheng, additional, Liu, Xiaoqing, additional, Pan, Wei, additional, Han, Fengzhen, additional, Mai, Jinzhuang, additional, Ou, Yanqiu, additional, Nie, Zhiqiang, additional, Gao, Xiangmin, additional, Wu, Yong, additional, Ohye, Richard G., additional, Chen, Jimei, additional, and Zhuang, Jian, additional

Published
2017
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24. Long noncoding RNA SNHG6 contributes to ventricular septal defect formation via negative regulation of miR-101 and activation of Wnt/β-catenin pathway

Author

Jiang, Yanping, Zhuang, Jian, Lin, Yanyan, Wang, Xiaoyun, Chen, Jianguo, and Han, Fengzhen

Abstract

This study aimed to investigate the role and regulatory mechanism of small nucleolar RNA host gene 6 (SNHG6), a long noncoding RNA, in the formation of ventricular septal defect (VSD). The expression of SNHG6 in fetal cardiac tissues with VSD, mouse heart embryo development and the differentiation of P19 cells into cardiomyocytes were determined. Moreover, the effect of aberrant expression of SNHG6 on P19 cell proliferation, cell cycle, apoptosis and differentiation was further analyzed to explore the role of SNHG6 in affecting myocardial development. Furthermore, the regulatory mechanism between SNHG6 and miR-101 as well as between SNHG6 and activation of Wnt/β-catenin pathway was investigated. SNHG6 was upregulated in fetal cardiac tissues with VSD, and decreased in the embryonic development of mice and differentiation of P19 cells into cardiomyocytes. Overexpression of SNHG6 inhibited P19 cell proliferation and induced apoptosis, as well as promoted cell differentiation into cardiomyocytes. Furthermore, SNHG6 could negative regulate the expression of miR-101, and the effects of SNHG6 on the modulation of P19 cell function were through negative regulation of miR-101. In addition, overexpression of SNHG6 activated Wnt/β-catenin pathway, which was reversed after overexpression of SNHG6 and miR-101 synchronously. Our study reveals that SNHG6 may contribute to VSD formation via negative regulation of miR-101 and activation of Wnt/β-catenin pathway. SNHG6 may constitute a potential therapeutic target in this disease.

Published
2019
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25. Case Report: Totally endoscopic minimally invasive mitral valve surgery during pregnancy: a case series.

Author

Wang Z, Zhong L, Guo H, Liu Y, Zhou C, Ye Y, Han F, and Huang H

Abstract

A totally endoscopic minimally invasive approach is widely used for cardiac valve surgery in normal adults. However, minimally invasive cardiac surgery during pregnancy is rarely reported. In addition to traditional median thoracotomy, totally endoscopic minimally invasive approaches can now be used for pregnant patients. We describe our experience with totally endoscopic cardiac valve surgery (TECVS) during pregnancy, which is safe for both mothers and fetuses., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (© 2024 Wang, Zhong, Guo, Liu, Zhou, Ye, Han and Huang.)

Published
2024
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