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1. How to Support Peer Resistance in Adolescents with Mild-To-Borderline Intellectual Disability? Intervention Development and Feasibility

Author: Eline Wagemaker, Elske Salemink, Hilde M. Huizenga, Han F. Bart, Tycho J. Dekkers, and Anika Bexkens
Abstract: Background: Adolescents with mild-to-borderline intellectual disability face peer resistance challenges, risking harmful or dangerous situations. Method: We designed a peer resistance group intervention at school for adolescents with mild-to-borderline intellectual disability, tested its feasibility (N = 4, M[subscript age] = 14.1, M[subscript IQ] = 78.8), adapted it, and tested it again (N = 6, M[subscript age] = 15.0, M[subscript IQ] = 72.8). Results: Study 1 demonstrated feasibility in recruitment, resources, and potential benefits on the distal outcome risk taking. However, attendance, obtained knowledge, and potential benefits on peer resistance, peer problems, and prosocial behaviour were suboptimal. Consequently, study 2 contained more learning by doing and individual lessons, resulting in higher attendance and greater personalization. While potential benefits on improved peer resistance measures were not observed, risk taking improved. Conclusions: Despite finding no potential benefits on peer resistance, running a peer resistance intervention for adolescents with mild-to-borderline intellectual disability at school is considered feasible.
Published: 2024
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2. Detailed Report on the Measurement of the Positive Muon Anomalous Magnetic Moment to 0.20 ppm

Author: Aguillard, D. P., Albahri, T., Allspach, D., Anisenkov, A., Badgley, K., Baeßler, S., Bailey, I., Bailey, L., Baranov, V. A., Barlas-Yucel, E., Barrett, T., Barzi, E., Bedeschi, F., Berz, M., Bhattacharya, M., Binney, H. P., Bloom, P., Bono, J., Bottalico, E., Bowcock, T., Braun, S., Bressler, M., Cantatore, G., Carey, R. M., Casey, B. C. K., Cauz, D., Chakraborty, R., Chapelain, A., Chappa, S., Charity, S., Chen, C., Cheng, M., Chislett, R., Chu, Z., Chupp, T. E., Claessens, C., Convery, M. E., Corrodi, S., Cotrozzi, L., Crnkovic, J. D., Dabagov, S., Debevec, P. T., Di Falco, S., Di Sciascio, G., Donati, S., Drendel, B., Driutti, A., Duginov, V. N., Eads, M., Edmonds, A., Esquivel, J., Farooq, M., Fatemi, R., Ferrari, C., Fertl, M., Fienberg, A. T., Fioretti, A., Flay, D., Foster, S. B., Friedsam, H., Froemming, N. S., Gabbanini, C., Gaines, I., Galati, M. D., Ganguly, S., Garcia, A., George, J., Gibbons, L. K., Gioiosa, A., Giovanetti, K. L., Girotti, P., Gohn, W., Goodenough, L., Gorringe, T., Grange, J., Grant, S., Gray, F., Haciomeroglu, S., Halewood-Leagas, T., Hampai, D., Han, F., Hempstead, J., Hertzog, D. W., Hesketh, G., Hess, E., Hibbert, A., Hodge, Z., Hong, K. W., Hong, R., Hu, T., Hu, Y., Iacovacci, M., Incagli, M., Kammel, P., Kargiantoulakis, M., Karuza, M., Kaspar, J., Kawall, D., Kelton, L., Keshavarzi, A., Kessler, D. S., Khaw, K. S., Khechadoorian, Z., Khomutov, N. V., Kiburg, B., Kiburg, M., Kim, O., Kinnaird, N., Kraegeloh, E., Krylov, V. A., Kuchinskiy, N. A., Labe, K. R., LaBounty, J., Lancaster, M., Lee, S., Li, B., Li, D., Li, L., Logashenko, I., Campos, A. Lorente, Lu, Z., Lucà, A., Lukicov, G., Lusiani, A., Lyon, A. L., MacCoy, B., Madrak, R., Makino, K., Mastroianni, S., Miller, J. P., Miozzi, S., Mitra, B., Morgan, J. P., Morse, W. M., Mott, J., Nath, A., Ng, J. K., Nguyen, H., Oksuzian, Y., Omarov, Z., Osofsky, R., Park, S., Pauletta, G., Piacentino, G. M., Pilato, R. N., Pitts, K. T., Plaster, B., Počanić, D., Pohlman, N., Polly, C. C., Price, J., Quinn, B., Qureshi, M. U. H., Ramachandran, S., Ramberg, E., Reimann, R., Roberts, B. L., Rubin, D. L., Sakurai, M., Santi, L., Schlesier, C., Schreckenberger, A., Semertzidis, Y. K., Shemyakin, D., Sorbara, M., Stapleton, J., Still, D., Stöckinger, D., Stoughton, C., Stratakis, D., Swanson, H. E., Sweetmore, G., Sweigart, D. A., Syphers, M. J., Tarazona, D. A., Teubner, T., Tewsley-Booth, A. E., Tishchenko, V., Tran, N. H., Turner, W., Valetov, E., Vasilkova, D., Venanzoni, G., Volnykh, V. P., Walton, T., Weisskopf, A., Welty-Rieger, L., Winter, P., Wu, Y., Yu, B., Yucel, M., Zeng, Y., and Zhang, C.
Subjects: High Energy Physics - Experiment, High Energy Physics - Phenomenology, Nuclear Experiment
Abstract: We present details on a new measurement of the muon magnetic anomaly, $a_\mu = (g_\mu -2)/2$. The result is based on positive muon data taken at Fermilab's Muon Campus during the 2019 and 2020 accelerator runs. The measurement uses $3.1$ GeV$/c$ polarized muons stored in a $7.1$-m-radius storage ring with a $1.45$ T uniform magnetic field. The value of $ a_{\mu}$ is determined from the measured difference between the muon spin precession frequency and its cyclotron frequency. This difference is normalized to the strength of the magnetic field, measured using Nuclear Magnetic Resonance (NMR). The ratio is then corrected for small contributions from beam motion, beam dispersion, and transient magnetic fields. We measure $a_\mu = 116 592 057 (25) \times 10^{-11}$ (0.21 ppm). This is the world's most precise measurement of this quantity and represents a factor of $2.2$ improvement over our previous result based on the 2018 dataset. In combination, the two datasets yield $a_\mu(\text{FNAL}) = 116 592 055 (24) \times 10^{-11}$ (0.20 ppm). Combining this with the measurements from Brookhaven National Laboratory for both positive and negative muons, the new world average is $a_\mu$(exp) $ = 116 592 059 (22) \times 10^{-11}$ (0.19 ppm)., Comment: 48 pages, 29 figures; 4 pages of Supplement Material; version accepted for publication in Physical Review D
Published: 2024

3. Measurement of the Positive Muon Anomalous Magnetic Moment to 0.20 ppm

Author: Aguillard, D. P., Albahri, T., Allspach, D., Anisenkov, A., Badgley, K., Baeßler, S., Bailey, I., Bailey, L., Baranov, V. A., Barlas-Yucel, E., Barrett, T., Barzi, E., Bedeschi, F., Berz, M., Bhattacharya, M., Binney, H. P., Bloom, P., Bono, J., Bottalico, E., Bowcock, T., Braun, S., Bressler, M., Cantatore, G., Carey, R. M., Casey, B. C. K., Cauz, D., Chakraborty, R., Chapelain, A., Chappa, S., Charity, S., Chen, C., Cheng, M., Chislett, R., Chu, Z., Chupp, T. E., Claessens, C., Convery, M. E., Corrodi, S., Cotrozzi, L., Crnkovic, J. D., Dabagov, S., Debevec, P. T., Di Falco, S., Di Sciascio, G., Drendel, B., Driutti, A., Duginov, V. N., Eads, M., Edmonds, A., Esquivel, J., Farooq, M., Fatemi, R., Ferrari, C., Fertl, M., Fienberg, A. T., Fioretti, A., Flay, D., Foster, S. B., Friedsam, H., Froemming, N. S., Gabbanini, C., Gaines, I., Galati, M. D., Ganguly, S., Garcia, A., George, J., Gibbons, L. K., Gioiosa, A., Giovanetti, K. L., Girotti, P., Gohn, W., Goodenough, L., Gorringe, T., Grange, J., Grant, S., Gray, F., Haciomeroglu, S., Halewood-Leagas, T., Hampai, D., Han, F., Hempstead, J., Hertzog, D. W., Hesketh, G., Hess, E., Hibbert, A., Hodge, Z., Hong, K. W., Hong, R., Hu, T., Hu, Y., Iacovacci, M., Incagli, M., Kammel, P., Kargiantoulakis, M., Karuza, M., Kaspar, J., Kawall, D., Kelton, L., Keshavarzi, A., Kessler, D. S., Khaw, K. S., Khechadoorian, Z., Khomutov, N. V., Kiburg, B., Kiburg, M., Kim, O., Kinnaird, N., Kraegeloh, E., Krylov, V. A., Kuchinskiy, N. A., Labe, K. R., LaBounty, J., Lancaster, M., Lee, S., Li, B., Li, D., Li, L., Logashenko, I., Campos, A. Lorente, Lu, Z., Lucà, A., Lukicov, G., Lusiani, A., Lyon, A. L., MacCoy, B., Madrak, R., Makino, K., Mastroianni, S., Miller, J. P., Miozzi, S., Mitra, B., Morgan, J. P., Morse, W. M., Mott, J., Nath, A., Ng, J. K., Nguyen, H., Oksuzian, Y., Omarov, Z., Osofsky, R., Park, S., Pauletta, G., Piacentino, G. M., Pilato, R. N., Pitts, K. T., Plaster, B., Počanić, D., Pohlman, N., Polly, C. C., Price, J., Quinn, B., Qureshi, M. U. H., Ramachandran, S., Ramberg, E., Reimann, R., Roberts, B. L., Rubin, D. L., Santi, L., Schlesier, C., Schreckenberger, A., Semertzidis, Y. K., Shemyakin, D., Sorbara, M., Stapleton, J., Still, D., Stöckinger, D., Stoughton, C., Stratakis, D., Swanson, H. E., Sweetmore, G., Sweigart, D. A., Syphers, M. J., Tarazona, D. A., Teubner, T., Tewsley-Booth, A. E., Tishchenko, V., Tran, N. H., Turner, W., Valetov, E., Vasilkova, D., Venanzoni, G., Volnykh, V. P., Walton, T., Weisskopf, A., Welty-Rieger, L., Winter, P., Wu, Y., Yu, B., Yucel, M., Zeng, Y., and Zhang, C.
Subjects: High Energy Physics - Experiment
Abstract: We present a new measurement of the positive muon magnetic anomaly, $a_\mu \equiv (g_\mu - 2)/2$, from the Fermilab Muon $g\!-\!2$ Experiment using data collected in 2019 and 2020. We have analyzed more than 4 times the number of positrons from muon decay than in our previous result from 2018 data. The systematic error is reduced by more than a factor of 2 due to better running conditions, a more stable beam, and improved knowledge of the magnetic field weighted by the muon distribution, $\tilde{\omega}'^{}_p$, and of the anomalous precession frequency corrected for beam dynamics effects, $\omega_a$. From the ratio $\omega_a / \tilde{\omega}'^{}_p$, together with precisely determined external parameters, we determine $a_\mu = 116\,592\,057(25) \times 10^{-11}$ (0.21 ppm). Combining this result with our previous result from the 2018 data, we obtain $a_\mu\text{(FNAL)} = 116\,592\,055(24) \times 10^{-11}$ (0.20 ppm). The new experimental world average is $a_\mu (\text{Exp}) = 116\,592\,059(22)\times 10^{-11}$ (0.19 ppm), which represents a factor of 2 improvement in precision., Comment: 8 pages, 3 figures
Published: 2023
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4. Clinical Efficacy of Taxol Plus Platinum (TP) Chemotherapy Combined with Delayed Administration of PD-1 Inhibitors in Patients with Locally Advanced, Recurrent or Metastatic Esophageal Squamous Cell Carcinoma: A Retrospective Study

Author: Shen L, Chen Z, Zhang Z, Wu Y, Ren Y, Li Y, Yin X, Han F, and Chen Y
Subjects: immune checkpoint inhibitors, chemotherapy, rational sequence, esophageal squamous cell carcinoma, peripheral blood parameters, Therapeutics. Pharmacology, RM1-950
Abstract: Lin Shen,1,&ast; Zixuan Chen,1,&ast; Zhi Zhang,2,&ast; Yunjiang Wu,3 Yue Ren,1 Ying Li,1 Yue Li,1 Xudong Yin,1 Fang Han,1 Yong Chen1 1Department of Radio-Chemotherapy, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou City, Jiangsu Province, People’s Republic of China; 2Department of Medical Oncology, Baoying Clinical College, Medical College of Yangzhou University, Yangzhou City, Jiangsu Province, People’s Republic of China; 3Department of Thoracic Surgery, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou City, Jiangsu Province, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Yong Chen, Department of Radio-Chemotherapy, Affiliated Hospital of Yangzhou University, Yangzhou University, Hanjiang Middle Road No. 368, Yangzhou, Jiangsu, 225009, People’s Republic of China, Tel +86-18051062926, Email chenyong_jsyz@sina.comPurpose: Immune checkpoint inhibitors (ICIs) combined with chemotherapy have become the first-line standard treatment for locally advanced or metastatic esophageal squamous cell carcinoma (ESCC). The evidence also demonstrates improved synergistic effects of chemotherapy when combined with delayed administration of ICIs. In this study, we conducted a retrospective investigation into the treatment efficacy of taxol plus platinum (TP) chemotherapy combined with delayed administration of PD-1 inhibitors for ESCC patients.Patients and Methods: Clinical data of ESCC patients who received PD-1 inhibitors 3– 5 days after TP chemotherapy as first-line treatment was retrospectively reviewed between January 2019 and April 2023. Clinical outcomes and treatment safety were analyzed. The potential roles of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), and pan-immune-inflammation value (PIV) were investigated.Results: A total of 34 locally advanced, recurrent or metastatic ESCC patients received PD-1 inhibitors 3– 5 days following TP chemotherapy were included. The objective response rate (ORR) and disease control rate (DCR) were 85.3% and 97.1% respectively. The median progression-free survival (PFS) and overall survival (OS) were 13.2 and 19.1 month respectively. Seven patients received radical surgery, 1 patient achieved pathologic complete response (pCR) and 3 patients achieved major pathologic response (MPR). Among the 27 patients without surgery, the median PFS and OS were 9.7 and 19.1 month respectively. A more favorable prognosis was correlated with NLR less than 3 at the 3rd and 4th cycle of immunochemotherapy. No significant correlations between other parameters (PLR, MLR and PIV) and prognosis were observed. A total of 22 patients developed grade 3– 4 toxicity events.Conclusion: The optimized sequence of PD-1 inhibitors administered 3– 5 days after TP chemotherapy as the first-line treatment of ESCC demonstrated favorable treatment efficacy. Pretreatment NLR of less than 3 at the 3rd and 4th cycle of immunochemotherapy is associated with a better prognosis.Keywords: immune checkpoint inhibitors, chemotherapy, rational sequence, esophageal squamous cell carcinoma, peripheral blood parameters
Published: 2024

5. Synthesis, Antimicrobial, and DNA-Binding Evaluation of Novel Schiff Bases Containing Tetrazole Moiety And Their Ni(II) and Pt(II) Complexes

Author: Ulular, M., Sarı, N., Han, F., Öğütcü, H., and Hasanoğlu Özkan, E.
Published: 2024
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6. Differences in Polysomnographic and Craniofacial Characteristics of Catathrenia Phenotypes: A Cluster Analysis

Author: Yu M, Hao Z, Xu L, Zhao L, Wen Y, Han F, and Gao X
Subjects: subtype, groaning, upper airway, treatment, osa, sleep-disordered breathing, Psychiatry, RC435-571, Neurophysiology and neuropsychology, QP351-495
Abstract: Min Yu,1– 3 Zeliang Hao,1– 3 Liyue Xu,4 Long Zhao,4 Yongfei Wen,4 Fang Han,4,&ast; Xuemei Gao1– 3,&ast; 1Department of Orthodontics, Peking University School and Hospital of Stomatology, Beijing, People’s Republic of China; 2Center for Oral Therapy of Sleep Apnea, Peking University Hospital of Stomatology, Beijing, People’s Republic of China; 3National Center for Stomatology, Beijing, 100081, People’s Republic of China; 4Sleep Division, Peking University People’s Hospital, Beijing, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Fang Han, Sleep Division, Peking University People’s Hospital, No. 11 Xizhimen South Street, Xicheng District, Beijing, 100044, People’s Republic of China, Tel +86-010-88324204, Email hanfang1@hotmail.com Xuemei Gao, Department of Orthodontics, Peking University School and Hospital of Stomatology, No. 22 Zhongguancun South Avenue, Haidian District, Beijing, 100081, People’s Republic of China, Tel/Fax +86-010-82195350, Email xmgao@263.netPurpose: Catathrenia is a rare sleeping disorder characterized by repetitive nocturnal groaning during prolonged expirations. Patients with catathrenia had heterogeneous polysomnographic, comorbidity, craniofacial characteristics, and responses to treatment. Identifying phenotypes of catathrenia might benefit the exploration of etiology and personalized therapy.Patients and Methods: Sixty-six patients diagnosed with catathrenia by full-night audio/video polysomnography seeking treatment with mandibular advancement devices (MAD) or continuous positive airway pressure (CPAP) were included in the cohort. Polysomnographic characteristics including sleep architecture, respiratory, groaning, and arousal events were analyzed. Three-dimensional (3D) and 2D craniofacial hard tissue and upper airway structures were evaluated with cone-beam computed tomography and lateral cephalometry. Phenotypes of catathrenia were identified by K-mean cluster analysis, and inter-group comparisons were assessed.Results: Two distinct clusters of catathrenia were identified: cluster 1 (n=17) was characterized to have more males (71%), a longer average duration of groaning events (18.5± 4.8 and 12.8± 5.7s, p=0.005), and broader upper airway (volume 41,386± 10,543 and 26,661± 6700 mm3, p< 0.001); cluster 2 (n=49) was characterized to have more females (73%), higher respiratory disturbance index (RDI) (median 1.0 [0.3, 2.0] and 5.2 [1.2, 13.3]/h, p=0.009), more respiratory effort-related arousals (RERA)(1 [1, 109] and 32 [13, 57)], p=0.005), smaller upper airway (cross-sectional area of velopharynx 512± 87 and 339± 84 mm2, p< 0.001) and better response to treatment (41.2% and 82.6%, p=0.004).Conclusion: Two distinct phenotypes were identified in patients with catathrenia, primary catathrenia, and catathrenia associated with upper airway obstruction, suggesting respiratory events and upper airway structures might be related to the etiology of catathrenia, with implications for its treatment.Keywords: subtype, groaning, upper airway, treatment, OSA, sleep-disordered breathing
Published: 2024

7. The Impact of Coping Styles on the Mental Health of Outstanding Physical Education Students in Shanghai During the Normalization Epidemic: The Chain Mediation Role of Meaning in Life and Prosocial Behavior

Author: Zhai F, Han F, and Wang Q
Subjects: coping style, mental health, meaning in life, prosocial behavior, Psychology, BF1-990, Industrial psychology, HF5548.7-5548.85
Abstract: Fang Zhai,1 Fulei Han,2 Qiulin Wang1 1College of Physical Education, Yangzhou University, Yangzhou, Jiangsu, 225009, People’s Republic of China; 2Kunshan No. 1 Vocational School in Jiangsu Province, Kunshan, Jiangsu, 215300, People’s Republic of ChinaCorrespondence: Qiulin Wang, Email wangql@yzu.edu.cnPurpose: The continuous spread of the epidemic has inflicted serious harm upon individual’s mental well-being, and effective coping mechanisms are associated with positive mental health outcomes. Prosocial behavior and a sense of meaning in life can enhance individuals’ subjective well-being, which can subsequently positively impact their mental health. Thus, in the context of epidemic prevention and control, this study investigates the relationship between the meaning in life, prosocial behavior, and coping styles of outstanding physical education students and the impact on their mental health.Methods: The study involved a questionnaire survey on 498 outstanding physical education students, consisting of 297 boys (mean age = 13.16) and 201 girls (mean age = 12.87 years). Subsequently, the data was analyzed using the mediating effect and Bootstrap tests.Results: The coping style positively predicted the meaning in life (β=0.294) and prosocial behavior (β=0.293). Conversely, mental health was predicted in a negative direction (β=– 0.494). Mental health negatively predicted prosocial behavior (β=– 0.810), although prosocial behavior positively predicted meaning in life (β=0.644). Finally, prosocial behavior negatively predicted mental health (β=– 0.513). Additionally, the interplay between prosocial behavior and meaning in life is established in terms of both the individual and chain mediating roles.Conclusion: This study demonstrates that coping styles during a normalized epidemic prevention and control situation directly impact the mental health of Shanghai’s outstanding physical education students. Additionally, these coping styles indirectly influence mental health through the mediating effects of meaning in life and prosocial behaviors. Furthermore, meaning in life and prosocial behaviors act as chain mediators in this relationship.Keywords: coping style, mental health, meaning in life, prosocial behavior
Published: 2024

8. Tensor Regularized Total Least Squares Methods with Applications to Image and Video Deblurring

Author: Han, F., Wei, Y., and Xie, P.
Subjects: Mathematics - Numerical Analysis
Abstract: Total least squares (TLS) is an effective method for solving linear equations with the situations, when noise is not just in observation matrices but also in mapping matrices. Moreover, the Tikhonov regularization is widely used in plenty of ill-posed problems. In this paper, we extend the regularized total least squares (RTLS) method from the matrix form due to Golub, Hansen and O'Leary, to the tensor form proposing the tensor regularized total least squares (TR-TLS) method for solving ill-conditioned tensor systems of equations. Properties and algorithms about the solution of the TR-TLS problem, which might be similar to those of the RTLS, are also presented and proved. Based on this method, some applications in image and video deblurring are explored. Numerical examples illustrate the TR-TLS, compared with the existing methods.
Published: 2022

9. Retraction Note to: CRYSTAL STRUCTURE AND ANTI-LIVER CANCER ACTIVITY OF A NEW TETRANUCLEAR Zn COMPLEX WITH 2-ETHOXY-6-METHYLIMINOMETHYL-PHENOL

Author: Li, Y., Wang, X., Zhang, J., Lu, C., Chen, S., Wu, C., Zhu, X. -C., and Han, F.
Published: 2024
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10. Nanoscale viscoelastic transition from solid-like to liquid-like enables ductile deformation in Fe-based metallic glass

Author: Jin, C.B., Wu, Y.Z., Wang, J.N., Han, F., Tan, M.Y., Wang, F.C., Xu, J., Yi, J., Li, M.C., Zhang, Y., Huo, J.T., Wang, J.Q., and Gao, M.
Published: 2024
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11. Eliminating metallurgical defects and achieving strength-ductility combination in selective laser melted martensitic stainless steel through high-pressure annealing

Author: Feng, H.Y., Yao, Z.Q., Gao, M., Han, F., Sun, Y.Y., Xu, J., Zhang, Y., Zhao, W.J., Li, D., Zhang, S.Z., Huo, J.T., and Wang, J.Q.
Published: 2024
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12. Measurement of the anomalous precession frequency of the muon in the Fermilab Muon g-2 experiment

Author: Albahri, T., Anastasi, A., Anisenkov, A., Badgley, K., Baeßler, S., Bailey, I., Baranov, V. A., Barlas-Yucel, E., Barrett, T., Basti, A., Bedeschi, F., Berz, M., Bhattacharya, M., Binney, H. P., Bloom, P., Bono, J., Bottalico, E., Bowcock, T., Cantatore, G., Carey, R. M., Casey, B. C. K., Cauz, D., Chakraborty, R., Chang, S. P., Chapelain, A., Charity, S., Chislett, R., Choi, J., Chu, Z., Chupp, T. E., Corrodi, S., Cotrozzi, L., Crnkovic, J. D., Dabagov, S., Debevec, P. T., Di Falco, S., Di Meo, P., Di Sciascio, G., Di Stefano, R., Driutti, A., Duginov, V. N., Eads, M., Esquivel, J., Farooq, M., Fatemi, R., Ferrari, C., Fertl, M., Fienberg, A. T., Fioretti, A., Flay, D., Frlež, E., Froemming, N. S., Fry, J., Gabbanini, C., Galati, M. D., Ganguly, S., Garcia, A., George, J., Gibbons, L. K., Gioiosa, A., Giovanetti, K. L., Girotti, P., Gohn, W., Gorringe, T., Grange, J., Grant, S., Gray, F., Haciomeroglu, S., Halewood-Leagas, T., Hampai, D., Han, F., Hempstead, J., Herrod, A. T., Hertzog, D. W., Hesketh, G., Hibbert, A., Hodge, Z., Holzbauer, J. L., Hong, K. W., Hong, R., Iacovacci, M., Incagli, M., Kammel, P., Kargiantoulakis, M., Karuza, M., Kaspar, J., Kawall, D., Kelton, L., Keshavarzi, A., Kessler, D., Khaw, K. S., Khechadoorian, Z., Khomutov, N. V., Kiburg, B., Kiburg, M., Kim, O., Kim, Y. I., King, B., Kinnaird, N., Kraegeloh, E., Kuchibhotla, A., Kuchinskiy, N. A., Labe, K. R., LaBounty, J., Lancaster, M., Lee, M. J., Lee, S., Leo, S., Li, B., Li, D., Li, L., Logashenko, I., Campos, A. Lorente, Lucà, A., Lukicov, G., Lusiani, A., Lyon, A. L., MacCoy, B., Madrak, R., Makino, K., Marignetti, F., Mastroianni, S., Miller, J. P., Miozzi, S., Morse, W. M., Mott, J., Nath, A., Nguyen, H., Osofsky, R., Park, S., Pauletta, G., Piacentino, G. M., Pilato, R. N., Pitts, K. T., Plaster, B., Počanić, D., Pohlman, N., Polly, C. C., Price, J., Quinn, B., Raha, N., Ramachandran, S., Ramberg, E., Ritchie, J. L., Roberts, B. L., Rubin, D. L., Santi, L., Schlesier, C., Schreckenberger, A., Semertzidis, Y. K., Shemyakin, D., Smith, M. W., Sorbara, M., Stöckinger, D., Stapleton, J., Stoughton, C., Stratakis, D., Stuttard, T., Swanson, H. E., Sweetmore, G., Sweigart, D. A., Syphers, M. J., Tarazona, D. A., Teubner, T., Tewsley-Booth, A. E., Thomson, K., Tishchenko, V., Tran, N. H., Turner, W., Valetov, E., Vasilkova, D., Venanzoni, G., Walton, T., Weisskopf, A., Welty-Rieger, L., Winter, P., Wolski, A., and Wu, W.
Subjects: High Energy Physics - Experiment, Nuclear Experiment
Abstract: The Muon g-2 Experiment at Fermi National Accelerator Laboratory (FNAL) has measured the muon anomalous precession frequency $\omega_a$ to an uncertainty of 434 parts per billion (ppb), statistical, and 56 ppb, systematic, with data collected in four storage ring configurations during its first physics run in 2018. When combined with a precision measurement of the magnetic field of the experiment's muon storage ring, the precession frequency measurement determines a muon magnetic anomaly of $a_{\mu}({\rm FNAL}) = 116\,592\,040(54) \times 10^{-11}$ (0.46 ppm). This article describes the multiple techniques employed in the reconstruction, analysis and fitting of the data to measure the precession frequency. It also presents the averaging of the results from the eleven separate determinations of \omega_a, and the systematic uncertainties on the result., Comment: 29 pages, 19 figures. Published in Physical Review D
Published: 2021
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13. Magnetic Field Measurement and Analysis for the Muon g-2 Experiment at Fermilab

Author: Albahri, T., Anastasi, A., Badgley, K., Baeßler, S., Bailey, I., Baranov, V. A., Barlas-Yucel, E., Barrett, T., Bedeschi, F., Berz, M., Bhattacharya, M., Binney, H. P., Bloom, P., Bono, J., Bottalico, E., Bowcock, T., Cantatore, G., Carey, R. M., Casey, B. C. K., Cauz, D., Chakraborty, R., Chang, S. P., Chapelain, A., Charity, S., Chislett, R., Choi, J., Chu, Z., Chupp, T. E., Conway, A., Corrodi, S., Cotrozzi, L., Crnkovic, J. D., Dabagov, S., Debevec, P. T., Di Falco, S., Di Meo, P., Di Sciascio, G., Di Stefano, R., Driutti, A., Duginov, V. N., Eads, M., Esquivel, J., Farooq, M., Fatemi, R., Ferrari, C., Fertl, M., Fienberg, A. T., Fioretti, A., Flay, D., Froemming, N. S., Gabbanini, C., Galati, M. D., Ganguly, S., Garcia, A., George, J., Gibbons, L. K., Gioiosa, A., Giovanetti, K. L., Girotti, P., Gohn, W., Gorringe, T., Grange, J., Grant, S., Gray, F., Haciomeroglu, S., Halewood-Leagas, T., Hampai, D., Han, F., Hempstead, J., Herrod, A. T., Hertzog, D. W., Hesketh, G., Hibbert, A., Hodge, Z., Holzbauer, J. L., Hong, K. W., Hong, R., Iacovacci, M., Incagli, M., Kammel, P., Kargiantoulakis, M., Karuza, M., Kaspar, J., Kawall, D., Kelton, L., Keshavarzi, A., Kessler, D., Khaw, K. S., Khechadoorian, Z., Khomutov, N. V., Kiburg, B., Kiburg, M., Kim, O., Kim, Y. I., King, B., Kinnaird, N., Kraegeloh, E., Kuchinskiy, N. A., Labe, K. R., LaBounty, J., Lancaster, M., Lee, M. J., Lee, S., Li, B., Li, D., Li, L., Logashenko, I., Campos, A. Lorente, Lucà, A., Lukicov, G., Lusiani, A., Lyon, A. L., MacCoy, B., Madrak, R., Makino, K., Marignetti, F., Mastroianni, S., Miller, J. P., Miozzi, S., Morse, W. M., Mott, J., Nath, A., Nguyen, H., Osofsky, R., Park, S., Pauletta, G., Piacentino, G. M., Pilato, R. N., Pitts, K. T., Plaster, B., Počanić, D., Pohlman, N., Polly, C. C., Price, J., Quinn, B., Raha, N., Ramachandran, S., Ramberg, E., Ritchie, J. L., Roberts, B. L., Rubin, D. L., Santi, L., Schlesier, C., Schreckenberger, A., Semertzidis, Y. K., Shemyakin, D., Smith, M. W., Sorbara, M., Stöckinger, D., Stapleton, J., Stoughton, C., Stratakis, D., Stuttard, T., Swanson, H. E., Sweetmore, G., Sweigart, D. A., Syphers, M. J., Tarazona, D. A., Teubner, T., Tewsley-Booth, A. E., Thomson, K., Tishchenko, V., Tran, N. H., Turner, W., Valetov, E., Vasilkova, D., Venanzoni, G., Walton, T., Weisskopf, A., Welty-Rieger, L., Winter, P., Wolski, A., and Wu, W.
Subjects: High Energy Physics - Experiment, Nuclear Experiment
Abstract: The Fermi National Accelerator Laboratory has measured the anomalous precession frequency $a^{}_\mu = (g^{}_\mu-2)/2$ of the muon to a combined precision of 0.46 parts per million with data collected during its first physics run in 2018. This paper documents the measurement of the magnetic field in the muon storage ring. The magnetic field is monitored by nuclear magnetic resonance systems and calibrated in terms of the equivalent proton spin precession frequency in a spherical water sample at 34.7$^\circ$C. The measured field is weighted by the muon distribution resulting in $\tilde{\omega}'^{}_p$, the denominator in the ratio $\omega^{}_a$/$\tilde{\omega}'^{}_p$ that together with known fundamental constants yields $a^{}_\mu$. The reported uncertainty on $\tilde{\omega}'^{}_p$ for the Run-1 data set is 114 ppb consisting of uncertainty contributions from frequency extraction, calibration, mapping, tracking, and averaging of 56 ppb, and contributions from fast transient fields of 99 ppb., Comment: Added one citation and corrected missing normalization in Eqs (35) and (36)
Published: 2021
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14. Measurement of the Positive Muon Anomalous Magnetic Moment to 0.46 ppm

Author: Abi, B., Albahri, T., Al-Kilani, S., Allspach, D., Alonzi, L. P., Anastasi, A., Anisenkov, A., Azfar, F., Badgley, K., Baeßler, S., Bailey, I., Baranov, V. A., Barlas-Yucel, E., Barrett, T., Barzi, E., Basti, A., Bedeschi, F., Behnke, A., Berz, M., Bhattacharya, M., Binney, H. P., Bjorkquist, R., Bloom, P., Bono, J., Bottalico, E., Bowcock, T., Boyden, D., Cantatore, G., Carey, R. M., Carroll, J., Casey, B. C. K., Cauz, D., Ceravolo, S., Chakraborty, R., Chang, S. P., Chapelain, A., Chappa, S., Charity, S., Chislett, R., Choi, J., Chu, Z., Chupp, T. E., Convery, M. E., Conway, A., Corradi, G., Corrodi, S., Cotrozzi, L., Crnkovic, J. D., Dabagov, S., De Lurgio, P. M., Debevec, P. T., Di Falco, S., Di Meo, P., Di Sciascio, G., Di Stefano, R., Drendel, B., Driutti, A., Duginov, V. N., Eads, M., Eggert, N., Epps, A., Esquivel, J., Farooq, M., Fatemi, R., Ferrari, C., Fertl, M., Fiedler, A., Fienberg, A. T., Fioretti, A., Flay, D., Foster, S. B., Friedsam, H., Frlež, E., Froemming, N. S., Fry, J., Fu, C., Gabbanini, C., Galati, M. D., Ganguly, S., Garcia, A., Gastler, D. E., George, J., Gibbons, L. K., Gioiosa, A., Giovanetti, K. L., Girotti, P., Gohn, W., Gorringe, T., Grange, J., Grant, S., Gray, F., Haciomeroglu, S., Hahn, D., Halewood-Leagas, T., Hampai, D., Han, F., Hazen, E., Hempstead, J., Henry, S., Herrod, A. T., Hertzog, D. W., Hesketh, G., Hibbert, A., Hodge, Z., Holzbauer, J. L., Hong, K. W., Hong, R., Iacovacci, M., Incagli, M., Johnstone, C., Johnstone, J. A., Kammel, P., Kargiantoulakis, M., Karuza, M., Kaspar, J., Kawall, D., Kelton, L., Keshavarzi, A., Kessler, D., Khaw, K. S., Khechadoorian, Z., Khomutov, N. V., Kiburg, B., Kiburg, M., Kim, O., Kim, S. C., Kim, Y. I., King, B., Kinnaird, N., Korostelev, M., Kourbanis, I., Kraegeloh, E., Krylov, V. A., Kuchibhotla, A., Kuchinskiy, N. A., Labe, K. R., LaBounty, J., Lancaster, M., Lee, M. J., Lee, S., Leo, S., Li, B., Li, D., Li, L., Logashenko, I., Campos, A. Lorente, Lucà, A., Lukicov, G., Luo, G., Lusiani, A., Lyon, A. L., MacCoy, B., Madrak, R., Makino, K., Marignetti, F., Mastroianni, S., Maxfield, S., McEvoy, M., Merritt, W., Mikhailichenko, A. A., Miller, J. P., Miozzi, S., Morgan, J. P., Morse, W. M., Mott, J., Motuk, E., Nath, A., Newton, D., Nguyen, H., Oberling, M., Osofsky, R., Ostiguy, J. -F., Park, S., Pauletta, G., Piacentino, G. M., Pilato, R. N., Pitts, K. T., Plaster, B., Počanić, D., Pohlman, N., Polly, C. C., Popovic, M., Price, J., Quinn, B., Raha, N., Ramachandran, S., Ramberg, E., Rider, N. T., Ritchie, J. L., Roberts, B. L., Rubin, D. L., Santi, L., Sathyan, D., Schellman, H., Schlesier, C., Schreckenberger, A., Semertzidis, Y. K., Shatunov, Y. M., Shemyakin, D., Shenk, M., Sim, D., Smith, M. W., Smith, A., Soha, A. K., Sorbara, M., Stöckinger, D., Stapleton, J., Still, D., Stoughton, C., Stratakis, D., Strohman, C., Stuttard, T., Swanson, H. E., Sweetmore, G., Sweigart, D. A., Syphers, M. J., Tarazona, D. A., Teubner, T., Tewsley-Booth, A. E., Thomson, K., Tishchenko, V., Tran, N. H., Turner, W., Valetov, E., Vasilkova, D., Venanzoni, G., Volnykh, V. P., Walton, T., Warren, M., Weisskopf, A., Welty-Rieger, L., Whitley, M., Winter, P., Wolski, A., Wormald, M., Wu, W., and Yoshikawa, C.
Subjects: High Energy Physics - Experiment, Nuclear Experiment
Abstract: We present the first results of the Fermilab Muon g-2 Experiment for the positive muon magnetic anomaly $a_\mu \equiv (g_\mu-2)/2$. The anomaly is determined from the precision measurements of two angular frequencies. Intensity variation of high-energy positrons from muon decays directly encodes the difference frequency $\omega_a$ between the spin-precession and cyclotron frequencies for polarized muons in a magnetic storage ring. The storage ring magnetic field is measured using nuclear magnetic resonance probes calibrated in terms of the equivalent proton spin precession frequency ${\tilde{\omega}'^{}_p}$ in a spherical water sample at 34.7$^{\circ}$C. The ratio $\omega_a / {\tilde{\omega}'^{}_p}$, together with known fundamental constants, determines $a_\mu({\rm FNAL}) = 116\,592\,040(54)\times 10^{-11}$ (0.46\,ppm). The result is 3.3 standard deviations greater than the standard model prediction and is in excellent agreement with the previous Brookhaven National Laboratory (BNL) E821 measurement. After combination with previous measurements of both $\mu^+$ and $\mu^-$, the new experimental average of $a_\mu({\rm Exp}) = 116\,592\,061(41)\times 10^{-11}$ (0.35\,ppm) increases the tension between experiment and theory to 4.2 standard deviations, Comment: 10 pages; 4 figures
Published: 2021
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15. Beam dynamics corrections to the Run-1 measurement of the muon anomalous magnetic moment at Fermilab

Author: Albahri, T., Anastasi, A., Badgley, K., Baeßler, S., Bailey, I., Baranov, V. A., Barlas-Yucel, E., Barrett, T., Bedeschi, F., Berz, M., Bhattacharya, M., Binney, H. P., Bloom, P., Bono, J., Bottalico, E., Bowcock, T., Cantatore, G., Carey, R. M., Casey, B. C. K., Cauz, D., Chakraborty, R., Chang, S. P., Chapelain, A., Charity, S., Chislett, R., Choi, J., Chu, Z., Chupp, T. E., Corrodi, S., Cotrozzi, L., Crnkovic, J. D., Dabagov, S., Debevec, P. T., Di Falco, S., Di Meo, P., Di Sciascio, G., Di Stefano, R., Driutti, A., Duginov, V. N., Eads, M., Esquivel, J., Farooq, M., Fatemi, R., Ferrari, C., Fertl, M., Fiedler, A., Fienberg, A. T., Fioretti, A., Flay, D., Frlež, E., Froemming, N. S., Fry, J., Gabbanini, C., Galati, M. D., Ganguly, S., Garcia, A., George, J., Gibbons, L. K., Gioiosa, A., Giovanetti, K. L., Girotti, P., Gohn, W., Gorringe, T., Grange, J., Grant, S., Gray, F., Haciomeroglu, S., Halewood-Leagas, T., Hampai, D., Han, F., Hempstead, J., Herrod, A. T., Hertzog, D. W., Hesketh, G., Hibbert, A., Hodge, Z., Holzbauer, J. L., Hong, K. W., Hong, R., Iacovacci, M., Incagli, M., Kammel, P., Kargiantoulakis, M., Karuza, M., Kaspar, J., Kawall, D., Kelton, L., Keshavarzi, A., Kessler, D., Khaw, K. S., Khechadoorian, Z., Khomutov, N. V., Kiburg, B., Kiburg, M., Kim, O., Kim, Y. I., King, B., Kinnaird, N., Korostelev, M., Kraegeloh, E., Kuchinskiy, N. A., Labe, K. R., LaBounty, J., Lancaster, M., Lee, M. J., Lee, S., Li, B., Li, D., Li, L., Logashenko, I., Campos, A. Lorente, Lucà, A., Lukicov, G., Lusiani, A., Lyon, A. L., MacCoy, B., Madrak, R., Makino, K., Marignetti, F., Mastroianni, S., Miller, J. P., Miozzi, S., Morse, W. M., Mott, J., Nath, A., Newton, D., Nguyen, H., Osofsky, R., Park, S., Pauletta, G., Piacentino, G. M., Pilato, R. N., Pitts, K. T., Plaster, B., Počanić, D., Pohlman, N., Polly, C. C., Price, J., Quinn, B., Raha, N., Ramachandran, S., Ramberg, E., Ritchie, J. L., Roberts, B. L., Rubin, D. L., Santi, L., Sathyan, D., Schlesier, C., Schreckenberger, A., Semertzidis, Y. K., Smith, M. W., Sorbara, M., Stöckinger, D., Stapleton, J., Stoughton, C., Stratakis, D., Stuttard, T., Swanson, H. E., Sweetmore, G., Sweigart, D. A., Syphers, M. J., Tarazona, D. A., Teubner, T., Tewsley-Booth, A. E., Thomson, K., Tishchenko, V., Tran, N. H., Turner, W., Valetov, E., Vasilkova, D., Venanzoni, G., Walton, T., Weisskopf, A., Welty-Rieger, L., Winter, P., Wolski, A., and Wu, W.
Subjects: Physics - Accelerator Physics, High Energy Physics - Experiment
Abstract: This paper presents the beam dynamics systematic corrections and their uncertainties for the Run-1 data set of the Fermilab Muon g-2 Experiment. Two corrections to the measured muon precession frequency $\omega_a^m$ are associated with well-known effects owing to the use of electrostatic quadrupole (ESQ) vertical focusing in the storage ring. An average vertically oriented motional magnetic field is felt by relativistic muons passing transversely through the radial electric field components created by the ESQ system. The correction depends on the stored momentum distribution and the tunes of the ring, which has relatively weak vertical focusing. Vertical betatron motions imply that the muons do not orbit the ring in a plane exactly orthogonal to the vertical magnetic field direction. A correction is necessary to account for an average pitch angle associated with their trajectories. A third small correction is necessary because muons that escape the ring during the storage time are slightly biased in initial spin phase compared to the parent distribution. Finally, because two high-voltage resistors in the ESQ network had longer than designed RC time constants, the vertical and horizontal centroids and envelopes of the stored muon beam drifted slightly, but coherently, during each storage ring fill. This led to the discovery of an important phase-acceptance relationship that requires a correction. The sum of the corrections to $\omega_a^m$ is 0.50 $\pm$ 0.09 ppm; the uncertainty is small compared to the 0.43 ppm statistical precision of $\omega_a^m$., Comment: 35 pages, 29 figures. Accepted by Phys. Rev. Accel. Beams
Published: 2021
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16. Achieving Ultra-Fine Grains and Improved Mechanical Properties in a Mg-Zn-Al-Ca Alloy via Forward Extrusion and Post Decreased-Temperature Equal Channel Angular Pressing

Author: Han, F. Y., Shi, Q., Zheng, C., Li, M. Z., Feng, H., Zhang, C. J., Zhang, S. Z., Fan, X. Y., Niu, X. F., Han, J. C., and Wang, T.
Published: 2023
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17. Progress in the Treatment of High Altitude Cerebral Edema: Targeting REDOX Homeostasis

Author: Li Y, Li C, Luo T, Yue T, Xiao W, Yang L, Zhang Z, Han F, Long P, and Hu Y
Subjects: high altitude cerebral edema, hypobaric hypoxia, redox homeostasis, mitochondria dysfunction, microglia, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950
Abstract: Yubo Li,1,2,&ast; Chengming Li,1,2,&ast; Tao Luo,3,&ast; Tian Yue,4 Wenjing Xiao,5 Ling Yang,1,2 Zaiyuan Zhang,6 Fei Han,3,&ast; Pan Long,3 Yonghe Hu6 1School of Clinical Medicine, Chengdu University of TCM, Chengdu, People’s Republic of China; 2Basic Medical Laboratory, The General Hospital of Western Theater Command, Chengdu, People’s Republic of China; 3Department of Ophthalmology, The General Hospital of Western Theater Command, Chengdu, People’s Republic of China; 4School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, People’s Republic of China; 5Department of Pharmacy, The General Hospital of Western Theater Command, Chengdu, People’s Republic of China; 6College of Medicine, Southwest Jiaotong University, Chengdu, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Pan Long, Department of Ophthalmology, The General Hospital of Western Theater Command, Rongdu Avenue &num;270, Chengdu, People’s Republic of China, Tel +86-181-9125-6132, Email longpan1005@qq.com Yonghe Hu, College of Medicine, Southwest Jiaotong University, No. 111, North First section of the Second Ring Road, Chengdu, People’s Republic of China, Tel +86-138-8059-6789, Email huyonghezyy@163.comAbstract: With the increasing of altitude activities from low-altitude people, the study of high altitude cerebral edema (HACE) has been revived. HACE is a severe acute mountain sickness associated with exposure to hypobaric hypoxia at high altitude, often characterized by disturbance of consciousness and ataxia. As for the pathogenesis of HACE, previous studies suggested that it might be related to the disorder of cerebral blood flow, the destruction of blood-brain barrier and the injury of brain parenchyma cells caused by inflammatory factors. In recent years, studies have confirmed that the imbalance of REDOX homeostasis is also involved in the pathogenesis of HACE, which mainly leads to abnormal activation of microglia and destruction of tight junction of vascular endothelial cells through the excessive production of mitochondrial-related reactive oxygen species. Therefore, this review summarizes the role of REDOX homeostasis and the potential of the treatment of REDOX homeostasis in HACE, which is of great significance to expand the understanding of the pathogenesis of HACE. Moreover, it will also be helpful to further study the possible therapy of HACE related to the key link of REDOX homeostasis.Keywords: high altitude cerebral edema, hypobaric hypoxia, REDOX homeostasis, mitochondria dysfunction, microglia
Published: 2023

18. Bibliometric Analysis of Publications in Clinical Trials on Knee Osteoarthritis Between 2001 and 2022

Author: Gu JY, Han F, Chen SY, and Zhang Q
Subjects: knee osteoarthritis, treatment, clinical trial, bibliometric analysis, public health., Medicine (General), R5-920
Abstract: Jin Yu Gu,1 Fei Han,2 Si-Yu Chen,2 Qing Zhang1 1Department of Orthopaedic, The Hospital of Wang Jing, China Academy of Chinese Medical Sciences, Beijing, People’s Republic of China; 2Department of Orthopaedic, The Hospital of Guang An Men, China Academy of Chinese Medical Sciences, Beijing, People’s Republic of ChinaCorrespondence: Qing Zhang, Department of Orthopaedic, The Hospital of Wang Jing, China Academy of Chinese Medical Sciences, Huajiadi Street, Chao Yang District, Beijing, 100102, People’s Republic of China, Tel +86-13911570607, Email 3219040781@stu.cpu.edu.cnPurpose: Clinical treatment of knee osteoarthritis has gained great interest, and numerous clinical studies have been reported. Few studies have described the detailed characterizations of clinical trials on knee osteoarthritis. This study is to identify, visualize, and characterize the clinical trials in knee osteoarthritis research.Design and Methods: Articles published in recent two decades were extracted from the Web of Science core collection database using a query based on MeSH terms and topics of knee osteoarthritis and clinical trial. Basic characteristics of publications were analyzed based on the publication year, authors, institutions, counties, and keywords covered in the article. CiteSpace and VOS viewer were used for data visualization. The data were retrieved on May 28, 2022.Results: A total of 1972 trials on knee osteoarthritis were identified. The number of publications has experienced rapid growth in the past two decades. America, England, and China had strong contributions in publication. Osteoarthritis and Cartilage, Annals of the Rheumatic Diseases and American Journal of Sports Medicine were highly cited and bellwether journals. Clustering mapping of the collaborative network, co-citation, and co-occurrence analyses showed that the research hotspots are mainly focused on disease-modifying medications, intra-articular injections, physical therapy for symptom control, lifestyle intervention, Chinese medicine treatment, and knee replacement.Conclusion: Clinical treatments of knee OA are evolving. Pharmacologic therapy, intra-articular therapy, nonpharmacologic therapy including exercise or diet, self-management programs, Chinese medicine treatment, and knee replacement were highly represented in clinical trials of knee OA. Adjustment of combination therapy may be the next study focus in the future.Keywords: knee osteoarthritis, treatment, clinical trial, bibliometric analysis, public health
Published: 2023

19. Daytime Hypercapnia Impairs Working Memory in Young and Middle-Aged Patients with Obstructive Sleep Apnea Hypopnea Syndrome

Author: Wu HM, Wang ZJ, Cheng CH, Su T, Wang J, Li YZ, Wang QJ, Han F, and Chen R
Subjects: hypercapnia, obstructive, sleep apnea, working memory, Psychiatry, RC435-571, Neurophysiology and neuropsychology, QP351-495
Abstract: Hua-Man Wu,1,2,&ast; Zhi-Jun Wang,1,&ast; Chao-Hong Cheng,1 Tong Su,1 Jing Wang,1 Ye-Zhou Li,3 Qiao-Jun Wang,4 Fei Han,4 Rui Chen1,4 1Department of Respiratory, the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People’s Republic of China; 2Department of Respiratory and Critical Care Medicine, Zigong First People’s Hospital, Zigong, Sichuan, People’s Republic of China; 3School of Medicine, the University of Manchester, Manchester, UK; 4Department of Sleeping Center, the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Rui Chen, Department of Respiratory/Department of Sleeping Center, the Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Suzhou, 215004, People’s Republic of China, Tel +86(0512)67784857, Email chenruigood@126.comPurpose: Obstructive sleep apnea hypopnea syndrome (OSAHS) can lead to cognitive impairment, though few studies have so far examined hypercapnia as its causal mechanism, due to the invasive nature of conventional arterial CO2 measurement. The study aims to investigate the effects of daytime hypercapnia on working memory in young and middle-aged patients with OSAHS.Patients and Methods: This prospective study screened 218 patients and eventually recruited 131 patients (aged 25– 60 years) with polysomnography (PSG)-diagnosed OSAHS. Using a cut-off of 45mmHg daytime transcutaneous partial pressure of carbon dioxide (PtcCO2), 86 patients were assigned into the normocapnic group and 45 patients into the hypercapnic group. Working memory was evaluated using the Digit Span Backward Test (DSB) and the Cambridge Neuropsychological Test Automated Battery.Results: Compared with the normocapnic group, the hypercapnic group performed worse in verbal, visual, and spatial working memory tasks. PtcCO2≥ 45mmHg was an independent predictor for lower DSB scores (OR=4.057), lower accuracy in the immediate Pattern Recognition Memory (OR=2.600), delayed Pattern Recognition Memory (OR=2.766) and Spatial Recognition Memory (OR=2.722) tasks, lower Spatial Span scores (OR=4.795), and more between errors in the Spatial Working Memory task (OR=2.734 and 2.558, respectively). Notably, PSG indicators of hypoxia and sleep fragmentation did not predict task performance.Conclusion: Hypercapnia may be plays an important role in working memory impairment in patients with OSAHS, perhaps more so than hypoxia and sleep fragmentation. Routine CO2 monitoring in these patients could prove of utility in clinical practices.Keywords: hypercapnia, obstructive, sleep apnea, working memory
Published: 2023

20. Polyphenols Can Improve Resin-Dentin Bond Durability by Promoting Amorphous Calcium Phosphate Nanoparticles to Backfill the Dentin Matrix

Author: Wang B, Han F, You R, Chen C, and Xie H
Subjects: polyphenols, collagen, amorphous calcium phosphate nanoparticles, remineralization, resin-dentin bonding, Medicine (General), R5-920
Abstract: Beibei Wang,1,&ast; Fei Han,1,&ast; Ran You,1 Chen Chen,2 Haifeng Xie1 1Department of Prosthodontics, Affiliated Stomatology Hospital, Nanjing Medical University; Jiangsu Province Key Laboratory of Oral Diseases, Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing, 210029, People’s Republic of China; 2Department of Endodontics, Affiliated Stomatology Hospital, Nanjing Medical University; Jiangsu Province Key Laboratory of Oral Diseases, Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing, 210029, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Haifeng Xie, Affiliated Stomatology Hospital, Nanjing Medical University, Han-Zhong Road 136th, Nanjing, 210029, People’s Republic of China, Tel +8625 69593081, Fax +8625 86516414, Email xhf-1980@126.comObjective: To investigate the effects of proanthocyanidins (PA), myricetin, resveratrol, and kaempferol on the modification of dentin collagen and the inhibition of matrix metalloproteinase (MMP) activity, and to evaluate their contributions to the biomimetic remineralization and resin-dentin bonding performance.Methods: Attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) and in situ zymography were applied to verify the collagen modification and MMP activity inhibition induced by these four polyphenols. Scanning electron microscopy/energy dispersive spectrometer (SEM/EDS) analysis, X-ray diffraction (XRD), ATR-FTIR, Vickers hardness numbers (VHN), and micro-computed tomography (micro-CT) were performed to characterize the remineralized dentin. Microtensile bond strength (μTBS) and nanoleakage were investigated to evaluate the effects of the four polyphenols on resin-dentin bonding durability.Results: ATR-FTIR and in situ zymography confirmed that these four polyphenols could modify dentin collagen and inhibit MMP activity, respectively. Chemoanalytic characterization exhibited the efficacies of the four polyphenols in promoting dentin biomimetic remineralization. The surface hardness of PA-pretreated dentin was the greatest. Micro-CT results demonstrated that the PAs group possessed the highest amount of dentin surface minerals and the lowest amount of deep-layer minerals. The surface and deep-layer mineral contents of the Myr group were higher than Res and Kae groups. Treatment with these four polyphenols significantly increased the initial μTBS compared with the control group without primer conditioning. μTBS decreased significantly during aging, and the decrease was more severe in the PAs and Kae groups than in the Myr and Res groups. With or without aging, the polyphenol groups exhibited relatively less fluorescence. However, the Myr and Res groups showed less serious nanoleakage after aging.Conclusion: PA, myricetin, resveratrol, and kaempferol can modify dentin collagen, inhibit MMP activity, promote biomimetic remineralization, and improve resin-dentin bond durability. Compared with PA and kaempferol, myricetin and resveratrol are more effective in improving resin-dentin bonding.Graphical Abstract: Keywords: polyphenols, collagen, amorphous calcium phosphate nanoparticles, remineralization, resin-dentin bonding
Published: 2023

21. Phosphate removal performance and mechanism of magnesium–lanthanum-modified coal gasification coarse slag

Author: Yang, B., Han, F., Bai, Y., Xie, Z., Shi, T., Wang, J., and Li, Y.
Published: 2023
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22. Not Only Excessive Daytime Sleepiness but Also Depression Symptoms, Chronological Age and Onset-Age Were Associated with Impulsivity in Narcolepsy Type 1 Patients

Author: Yang Y, Zhang J, Han F, and Xiao F
Subjects: narcolepsy, impulsivity, excessive daytime sleepiness, depression, smooth curve fitting, Psychiatry, RC435-571, Neurophysiology and neuropsychology, QP351-495
Abstract: Yang Yang,1 Jun Zhang,2 Fang Han,3 Fulong Xiao4 1Department of Neuropsychiatry and Behavioral Neurology and Clinical Psychology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, People’s Republic of China; 2Department of Neurology, Peking University People’s Hospital, Beijing, 100044, People’s Republic of China; 3Sleep Medicine Center, Department of Respiratory and Critical Care Medicine, Peking University People’s Hospital, Beijing, 100044, People’s Republic of China; 4Department of General Internal Medicine, Peking University People’s Hospital, Beijing, 100044, People’s Republic of ChinaCorrespondence: Fang Han; Fulong Xiao, Peking University People’s Hospital, No. 11, South Avenue, Beijing, People’s Republic of China, Email hanfang1@hotmail.com; xiaofulong1681@163.comObjective: To detect the factors associated with total and subscales impulsivity scores in narcolepsy and further explore the non-linear relationship between these factors and impulsivity score.Methods: One hundred and fifty-eight narcolepsy type 1 (NT1) patients were involved in this cross-sectional study. Patients completed questionnaires evaluating impulsivity symptoms (Barratt impulse scale-11, BIS-11), depression symptoms (Center for Epidemiologic Studies Depression Scale for Children, CES-DC or Self-Rating Depression Scale, SDS) and sleepiness (Epworth Sleepiness Scale, ESS). Parameters from polysomnography and multiple sleep latency test were also collected. Linear regression analysis was performed to detect the factors associated with total and subscales impulsivity scores. Then, generalized additive models and smooth curve fitting were performed to explore the non-linear relationship between chronological age and impulsivity scores.Results: Factors associated with higher total impulsivity score were higher ESS, older onset and adolescents. Factors associated with higher attentional impulsivity score were higher ESS, older onset and adolescents. Factors associated with higher motor impulsivity score were higher ESS, younger onset and depression symptoms. Factors associated with higher non-planning impulsivity score were adolescents, older onset and depression symptoms. A non-linear relationship between age and impulsivity scores (total impulsivity score, attentional impulsivity score and non-planning impulsivity score) was detected in NT1 patients.Conclusion: Not only excessive daytime sleepiness but also onset-age, depression symptoms and chronological age were associated with impulsivity in NT1 patients. The non-linear relationship between age and impulsivity scores suggested brain and mental development alterations in NT1 patients.Keywords: narcolepsy, impulsivity, excessive daytime sleepiness, depression, smooth curve fitting
Published: 2022

23. The Failure Patterns of Nasopharygeal Carcinoma After Intensity-Modulated Radiotherapy and Implications for Surveillance

Author: Tian Y, Huang WZ, Zeng L, Bai L, Han F, and Lan Y
Subjects: failure patterns, intensity-modulated radiotherapy, nasopharyngeal carcinoma, surveillance, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Yunming Tian,1 Wei-Zeng Huang,2 Lei Zeng,3 Li Bai,1 Fei Han,4,* Yuhong Lan1,* 1Department of Radiation Oncology, Huizhou Central People’s Hospital, Huizhou, Guangdong Province, People’s Republic of China; 2Department of Medical Oncology, Huizhou First Hospital, Huizhou, Guangdong Province, People’s Republic of China; 3Department of Medical Oncology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jixiang Province, People’s Republic of China; 4Department of Radiation Oncology, Sun Yat-Sen University Cancer Centre, State Key Laboratory of Oncology in South China, Guangzhou, Guangdong Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Fei Han, Department of Radiation Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong Province, People’s Republic of China, Email hanfeisysucc@126.com Yuhong Lan, Department of Radiation Oncology, Hui Zhou Municipal Central Hostpital, Huizhou, Guangdong Province, People’s Republic of China, Email lanyuhonghzyy@126.comObjective: To investigate the treatment outcomes, failure patterns and surveillance strategy in patients with nasopharyngeal carcinoma (NPC) after intensity-modulated radiotherapy (IMRT).Methods: A cohort of patients with NPC who had received the full course of IMRT between 2008 and 2012 were retrospectively analyzed. The failure patterns, time to recurrence, and detection methods were recorded. The survival was calculated using the Kaplan–Meier method. Multivariate proportional hazard regression models were used to test the prognostic factors.Results: In total, 2607 patients with NPC treated with IMRT were recruited. After the median follow-up of 112 months, 402 (15.4%) patients experienced distant metastasis, 225 (8.6%) patients had local recurrence, and 77 (3.0%) patients had regional recurrences. The 10-year overall survival (OS), local recurrence-free survival (LRFS), and distant metastasis-free survival (DMFS) rates were 74.5%, 90.1%, and 79.3%, respectively. The factors of male sex, age > 50 years, lactate dehydrogenase > 245 IU/L, advanced T classification, and advanced N classification were associated with poor OS. The N disease classification was the most important factor in predicting distant metastasis, and advanced T disease classification for high risk of local recurrence. For patients with T1 disease, the incidence of local recurrence was less than 2%, and the incidence of distant metastasis was less than 5% for patients with N0 disease. About 83% of the recurrence occurred in the first 5 years, and 20% of the recurrences showed no symptoms.Conclusion: High rate of local-regional control can be achieved for patients with NPC after IMRT, while distant metastasis remains as the major cause of failures. Patients with advanced N classification has high risk to develop distant metastasis, and most occurred within 5 years. Developing rational and individualized surveillance strategies based on the high risk factors of recurrence is helpful to balance the survival benefit and medical cost.Keywords: failure patterns, intensity-modulated radiotherapy, nasopharyngeal carcinoma, surveillance
Published: 2022

24. The effect of grain size and rolling reduction on microstructure evolution and annealing hardening response of a Mg-3Gd alloy

Author: Han, F., Luo, X., Liu, Q., Hou, Z., Marthinsen, K., Wu, G.L., Hatzoglou, C., Kontis, P., and Huang, X.
Published: 2023
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25. Salt Marsh Accretion With and Without Deep Soil Subsidence as a Proxy for Sea-Level Rise

Author: van Dobben, Han F., de Groot, Alma V., and Bakker, Jan P.
Published: 2022
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26. Introduction Other Argonauts Chapters in the History of Pre-Malinowskian Ethnography

Author: Delgado Rosa, Frederico, primary and Vermeulen, Han F., additional
Published: 2022
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27. Chapter 2 Anthropology in the Netherlands: Past, Present, and Future

Author: Vermeulen, Han F., primary
Published: 2022
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28. Conclusion Founders of Anthropology and Their Predecessors

Author: Vermeulen, Han F., primary and Delgado Rosa, Frederico, additional
Published: 2022
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29. Comparison of Ring Pulse Oximetry Using Reflective Photoplethysmography and PSG in the Detection of OSA in Chinese Adults: A Pilot Study

Author: Zhao R, Xue J, Zhang X, Peng M, Li J, Zhou B, Zhao L, Penzel T, Kryger M, Dong XS, Gao Z, and Han F
Subjects: obstructive sleep apnea, reflective photoplethysmography, pulse oximetry, polysomnography, Psychiatry, RC435-571, Neurophysiology and neuropsychology, QP351-495
Abstract: Rui Zhao,1 Jianbo Xue,1 Xueli Zhang,1 Maohuan Peng,1 Jing Li,1 Bing Zhou,1 Long Zhao,1 Thomas Penzel,2 Meir Kryger,3 Xiao Song Dong,1 Zhancheng Gao,1 Fang Han1 1Department of Pulmonary and Critical Care Medicine, Peking University People’s Hospital, Beijing, People’s Republic of China; 2Sleep Medicine Center, Charité-Universitätsmedizin, Berlin, Germany; 3Division of Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USACorrespondence: Xiao Song Dong; Zhancheng Gao, Department of Pulmonary and Critical Care Medicine, Peking University People’s Hospital, No. 11 Xizhimen Nandajie, Xicheng District, Beijing, 100044, People’s Republic of China, Email dongxiaosong@pkuph.edu.cn; zcgao@bjmu.edu.cnObjective: A novel ring-worn oximeter (Circul) uses reflective photoplethysmography and automated signal processing to calculate oxygen desaturations. We evaluated the ability of Circul to detect obstructive sleep apnea in Chinese adults.Methods: We recruited 207 Chinese Han subjects: 70% males, mean age 48.2± 14.7 years, mean BMI 27.6± 4.8 kg/m2 and mean AHI 28.6± 25.2 events/h. All participants underwent simultaneous polysomnography (PSG) and Circul testing in a sleep laboratory. Oxygen desaturation index (ODI), mean oxygen saturation (MSpO2), cumulative time at SpO2< 90% (CT90), cumulative percentage of sleep time spent with SpO2< 90% (CT90/TST) were derived and compared for the Circul and the PSG.Results: The ODI was 25.3± 24.5 events/h using PSG and 22.2± 24.5 events/h using Circul (P< 0.0001), with an intraclass correlation coefficient (ICC) of 0.884. CT90 and CT90/TST between the two methods were not different; the MSpO2 level calculated by PSG was slightly lower than Circul, 95.0% (93.0– 96.0%) vs 95.3% (93.9– 96.6%), P< 0.0001. Circul-ODI had a good correlation (r=0.91, p< 0.0001) and close agreement with PSG-AHI (Bland-Altman analysis: Mean Difference 6.4, 95% CI − 14.8 to 27.5 events/h). Using a threshold of AHI ≥ 5 events/h, the Circul had 87% sensitivity, 83% specificity, 5.09 positive likelihood ratio (LR+), 86% accuracy, and 0.929 area under the curve (AUC).Conclusion: Circul ring pulse oximetry can detect OSA with reasonable reliability. The Circul system is a reliable and comfortable choice for OSA assessment.Keywords: obstructive sleep apnea, reflective photoplethysmography, pulse oximetry, polysomnography
Published: 2022

30. Has the COVID-19 Pandemic Traumatized Us Collectively? The Impact of the COVID-19 Pandemic on Mental Health and Sleep Factors via Traumatization: A Multinational Survey

Author: Holzinger B, Nierwetberg F, Chung F, Bolstad CJ, Bjorvatn B, Chan NY, Dauvilliers Y, Espie CA, Han F, Inoue Y, Leger D, Macêdo T, Matsui K, Merikanto I, Morin CM, Mota-Rolim SA, Partinen M, Plazzi G, Penzel T, Sieminski M, Wing YK, Scarpelli S, Nadorff MR, and De Gennaro L
Subjects: covid-19, nightmares, mental health, sleep, post-traumatic stress disorder, collective trauma, Psychiatry, RC435-571, Neurophysiology and neuropsychology, QP351-495
Abstract: Brigitte Holzinger,1,2 Franziska Nierwetberg,1 Frances Chung,3 Courtney J Bolstad,4 Bjørn Bjorvatn,5 Ngan Yin Chan,6 Yves Dauvilliers,7 Colin A Espie,8 Fang Han,9 Yuichi Inoue,10 Damien Leger,11 Tainá Macêdo,12 Kentaro Matsui,13,14 Ilona Merikanto,15,16 Charles M Morin,17 Sérgio A Mota-Rolim,18 Markku Partinen,19 Giuseppe Plazzi,20,21 Thomas Penzel,22 Mariusz Sieminski,23 Yun Kwok Wing,6 Serena Scarpelli,24 Michael R Nadorff,4,25 Luigi De Gennaro24,26 1Institute for Consciousness and Dream Research, Vienna, Austria; 2Medical University Vienna, Postgraduate Master ULG Sleep Coaching, Vienna, Austria; 3Department of Anesthesiology and Pain Medicine, University Health Network, University of Toronto, Toronto, ON, Canada; 4Mississippi State University, Mississippi State, MS, USA; 5Department of Global Public Health and Primary Care, University of Bergen and Norwegian Competence Center for Sleep Disorders, Haukeland University Hospital, Bergen, Norway; 6Li Chiu Kong Family Sleep Assessment Unit, Department of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, Special Administrative Region, People’s Republic of China; 7Sleep-Wake Disorders Unit, Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier, INM, Univ Montpellier, INSERM, Montpellier, France; 8Sir Jules Thorn Sleep & Circadian Neuroscience Institute (SCNi), University of Oxford, Oxford, UK; 9Department of Pulmonary and Critical Care Medicine, Peking University People’s Hospital, Beijing, People’s Republic of China; 10Tokyo Medical University, Tokyo, Japan; 11Université de Paris, APHP, Hôtel-Dieu, Centre du Sommeil et de la Vigilance, Paris, France; 12Department of Psychology, Federal University of Rio Grande do Norte, Natal, Brazil; 13Department of Laboratory Medicine, National Center Hospital, National Center of Neurology and Psychiatry, Kodaira, Japan; 14Department of Psychiatry, Tokyo Women’s Medical University, Tokyo, Japan; 15SleepWell Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland; 16Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland; 17École de Psychologie, Centre d’étude des troubles du sommeil, Centre de recherche CERVO/Brain Research Center, Université Laval, Québec, QC, Canada; 18Brain Institute, Physiology and Behavior Department, and Onofre Lopes University Hospital - Federal University of Rio Grande do Norte, Natal, Brazil; 19Helsinki Sleep Clinic, Terveystalo Healthcare, and Department of Neurosciences, Clinicum, University of Helsinki, Helsinki, Finland; 20IRCCS, Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy; 21Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy; 22Sleep Medicine Center, Charité Universitätsmedizin Berlin, Berlin, Germany; 23Department of Emergency Medicine, Medical University of Gdansk, Gdansk, Poland; 24Department of Psychology, Sapienza University of Rome, Rome, Italy; 25Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA; 26IRCCS Fondazione Santa Lucia, Rome, ItalyCorrespondence: Brigitte Holzinger, Tel +43 699 101 99 042, Email brigitte.holzinger@meduniwien.ac.atPurpose: The COVID-19 pandemic affects mental health and sleep, resulting in frequent nightmares. Therefore, identifying factors associated with nightmare frequency is important, as it can indicate mental health issues. The study aimed to investigate increases in nightmare frequency comparing the pre-pandemic and pandemic period, and identify its risk factors. Further, the mediating role of post-traumatic stress disorder symptoms between the pandemic and nightmares is explored.Patients and Methods: For this cross-sectional survey data were obtained via self-rating online survey (ICOSS: details in Partinen et al, 2021), which was open to anyone older than 18 years. The final volunteer sample consisted of 15,292 participants, divided according to their nightmare frequency (high: ≥ 1– 2 nights/week; low: < 1– 2 nights/week). A total of 9100 participants were excluded if answers on variables of interest were missing or receiving rewards for participation. Chi-square tests identified changes of nightmare frequency. Predictors of high nightmare frequency were assessed using logistic regression and presented as Odds Ratios. Post-hoc mediation models were used to investigate the role of post-traumatic stress symptoms (PTSS).Results: The mean age was 41.63 (SD=16.55) with 64.05% females. High nightmare frequency increased significantly from 13.24% to 22.35% during the pandemic. Factors associated with it included self-reported PTSS (OR=2.11), other mental disorders and various sleep disorders or problems. Financial burden due to the pandemic, confinement, having had COVID-19, and work situation during the pandemic were associated with nightmare frequency, those relations were partly mediated through PTSS.Conclusion: Our results display the pandemic influence on nightmare frequency, which in turn connects to multiple mental health and sleep factors. These relations were partly mediated through PTSS. The COVID-19 pandemic appears to have caused traumatization of a substantial proportion of society. Health care workers should consider nightmares in their screening routines, as it might indicate PTSS and/or other mental and sleep disorders.Keywords: COVID-19, nightmares, mental health, sleep, post-traumatic stress disorder, collective trauma
Published: 2022

31. Sleep Disturbances in Chinese Children with Epilepsy: Associations with Behavioral Problems and Quality of Life

Author: Zhao F, Sun X, Wang Y, Zhou Y, He Y, Wang C, Han F, Liu J, Tsai SY, Wang G, and Wang J
Subjects: sleep disturbances, behavioral problems, quality of life, epilepsy, children, Psychiatry, RC435-571, Neurophysiology and neuropsychology, QP351-495
Abstract: Fen Zhao,1,&ast; Xiaoning Sun,2,&ast; Yingyan Wang,1 Yunqing Zhou,1 Yingzhong He,1 Cuijin Wang,1 Feng Han,1 Jie Liu,1 Shao-Yu Tsai,3 Guanghai Wang,2 Jiwen Wang1 1Department of Pediatric Neurology, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, People’s Republic of China; 2Paediatric Translational Medicine Institute, Department of Developmental and Behavioral Pediatrics, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, People’s Republic of China; 3School of Nursing, College of Medicine, National Taiwan University, Taipei, Taiwan&ast;These authors contributed equally to this workCorrespondence: Guanghai Wang, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, 1678 Dongfang Road, Shanghai, 200127, People’s Republic of China, Email wang-guanghai@163.com Jiwen Wang, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, 1678 Dongfang Road, Shanghai, 200127, People’s Republic of China, Email wangjiwen@scmc.com.cnObjective: To investigate the association between sleep disturbances and behavioral problems as well as quality of life (QOL) in Chinese children with epilepsy.Methods: Caregivers of 167 epileptic children aged 3 to 12 years completed the Child Sleep Habits Questionnaire (CSHQ), the Strengths and Difficulties Questionnaire (SDQ), and the Pediatric Quality of Life Inventory (PedsQL™, 4.0 Core).Results: The prevalence of sleep disturbances (CSHQ total score > 41) in epileptic children was 73.7% [95% CI (66.9%.80.4%)]. Epileptic children with sleep disturbances demonstrated more behavioral problems and lower QOL compared to those without sleep disturbances. Sleep disturbances such as sleep anxiety and daytime sleepiness were associated with more behavioral problems and lower QOL (p < 0.05). Linear regression analyses showed that higher disturbance in sleep duration domain were associated with more behavioral problems, while higher sleep disordered breathing domains was associated with lower QOL (p < 0.05). The interaction between sleep disturbances and behavioral problems in predicting QOL was not significant. The sensitivity analysis using 48 as an alternative cutoff for CSHQ total score obtained consistent results.Conclusion: Sleep disturbances occur frequently among Chinese children with epilepsy, and are associated with more behavioral problems and lower QOL. The sleep disturbance-QOL association is unlikely contingent on behavioral problems. This study highlights the necessity of evaluating and treating sleep disturbances multidimensionally among children with epilepsy to promote their whole health and wellbeing.Keywords: sleep disturbances, behavioral problems, quality of life, epilepsy, children
Published: 2022

32. Symptomatic Unilateral Triceps Medial Head Snapping and Subluxating Ulnar Nerve without Neuropathy after Push-Ups: A Case Report

Author: Lim WLB and Han F
Subjects: snapping elbow, ulnar nerve subluxation, medial head triceps snapping, surgical treatment, Orthopedic surgery, RD701-811
Abstract: The coexistence of ulnar nerve subluxation and snapping medial head triceps is an uncommon occurrence. There have been few studies and case reports since it was first described in 1970. In this article, we present a case in which the condition occurred after a push-up. We analysed the pathoanatomy of the condition, and reviewed the literature regarding potential causes, typical presentations of the coexistence of both ulnar nerve subluxation and medial snapping triceps and describe our surgical technique in treatment. Elbow pain is very often under evaluated as many physicians may not be aware that elbow pain could be attributed to the coexistence of both ulnar nerve subluxation and medial snapping triceps. A thorough evaluation with physical examination and imaging are recommended. Early surgery with an appropriate rehabilitation programme may hasten recovery and return to sports in patients who continue to remain symptomatic following a trial of conservative therapy.
Published: 2022
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33. Nocturnal Blood Pressure Fluctuation in Patients With Obstructive Sleep Apnea Complicated With and Without Hypertension

Author: Zhongming, H., primary, Han, M.-R., additional, Jiang, X.-L., additional, Wu, S., additional, Ma, S.-L., additional, Shi, J., additional, Zhang, Q.-L., additional, Yang, H.-M., additional, Wu, Y., additional, Da, P., additional, Han, F., additional, and Wang, H.-L., additional
Published: 2024
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34. Proteomic and Morphological Profiling of Mice Ocular Tissue During High-altitude Acclimatization Process: An Animal Study at Lhasa

Author: Hou J, Zheng D, Wen X, Xiao W, Han F, Lang H, Xiong S, Jiang W, Hu Y, He M, and Long P
Subjects: altitude response, ocular proteomics analysis, cornea edema, choroid thickening, post-translational modification, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950
Abstract: Jun Hou,1,&ast; Dezhi Zheng,2,&ast; Xudong Wen,3,&ast; Wenjing Xiao,4 Fei Han,5 Hongmei Lang,6 Shiqiang Xiong,1 Wei Jiang,5 Yonghe Hu,4 Mengshan He,7 Pan Long4,5 1Department of Cardiology, Chengdu Third People’s Hospital/Affiliated Hospital of Southwest Jiaotong University, Chengdu, People’s Republic of China; 2Department of Cardiovascular Surgery, the 960th Hospital of the PLA Joint Logistic Support Force, Jinan, People’s Republic of China; 3Department of Gastroenterology and Hepatology, Chengdu First People’s Hospital, Chengdu, People’s Republic of China; 4School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, People’s Republic of China; 5Department of Ophthalmology, the General Hospital of Western Theater Command, Chengdu, People’s Republic of China; 6The Center of Obesity and Metabolic Diseases, Department of General Surgery, Chengdu Third People’s Hospital & the Affiliated Hospital of Southwest Jiaotong University, Chengdu, People’s Republic of China; 7Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi’an, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Pan Long, Department of Ophthalmology, the General Hospital of Western Theater Command, Rongdu Avenue #270, Chengdu, People’s Republic of China, Tel +86-181-9125-6132, Email longpan1005@qq.com Yonghe Hu, School of Materials Science and Engineering, Southwest Jiaotong University, No. 111, North First Section of the Second Ring Road, Chengdu, People’s Republic of China, Tel +86-138-8059-6789, Email huyonghe789@sina.comPurpose: High-altitude environment mainly with hypobaric hypoxia could induce pathological alterations in ocular tissue. Previous studies have mostly focused on sporadic case reports and simulated high-altitude hypoxia experiments. This aim of this study was to explore the proteomic and morphological changes of ocular tissue in mice at real altitude environment.Methods: In this study, mice were flown from Chengdu (elevation: 500 m) to Lhasa (elevation: 3600 m). After exposure for 1day, 3, 6, 10, 20, 30, and 40days, the mice were euthanatized to obtain blood and ocular tissue. Serological tests, ocular pathological examinations, integral ocular proteomics analysis, and Western blot were conducted.Results: We focused on acute phase (1– 3 days) and chronic phase (> 30 days) during high-altitude acclimatization. Serum interleukin-1 was increased at 3 days, while superoxide dismutase, interleukin-6, and tumor necrosis factor-α showed no statistical changes. H&E staining demonstrated that the cornea was edematous at 3 days and exhibited slower proliferation at 30 days. The choroid showed a consistently significant thickening, while there existed no noticeable changes in retinal thickness. Overall, 4073 proteins were identified, among which 71 and 119 proteins were detected to have significant difference at 3 days and 40 days when compared with the control group. Functional enrichment analysis found the differentiated proteins at 3 days exposure functionally related with response to radiation, dephosphorylation, negative regulation of cell adhesion, and erythrocyte homeostasis. Moreover, the differential profiles of the proteins at 40 days exposure exhibited changes of regulation of complement activation, regulation of protein activation cascade, regulation of humoral immune response, second-messenger-mediated signaling, regulation of leukocyte activation, and cellular iron homeostasis. Interestingly, we found the ocular proteins with lactylation modification were increased along high-altitude adaptation.Conclusion: This is the first work reporting the ocular proteomic and morphological changes at real high-altitude environment. We expect it would deep the understanding of ocular response during altitude acclimatization.Keywords: altitude response, ocular proteomics analysis, cornea edema, choroid thickening, post-translational modification
Published: 2022

35. Influence of Acidic Environment on Hydrolytic Stability of MDP-Ca Salts with Nanolayered and Amorphous Structures

Author: Zhao Q, Gao Y, Jin X, Han F, Chen K, and Chen C
Subjects: 10-methacryloyloxydecyl dihydrogen phosphate calcium salts, nanolayering, hydrolysis, molecular dynamics simulations, dentine bonding, Medicine (General), R5-920
Abstract: Qing Zhao,1,&ast; Yixue Gao,2,&ast; Xin Jin,1 Fei Han,2 Kai Chen,3 Chen Chen1 1Department of Endodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, Jiangsu Province Key Laboratory of Oral Diseases, Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing, 210029, People’s Republic of China; 2Department of Prosthodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, Jiangsu Province Key Laboratory of Oral Diseases, Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing, 210029, People’s Republic of China; 3Collaborative Innovation Center of Atmospheric Environment and Equipment Technology, Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control, School of Environmental Science and Engineering, Nanjing University of Information Science and Technology, Nanjing, 210044, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Chen Chen, Department of Endodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, Jiangsu Province Key Laboratory of Oral Diseases, Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing, 210029, People’s Republic of China, Tel +8625 6959 3031, Fax +8625 8651 6414, Email ccchicy@njmu.edu.cnPurpose: This study aimed to investigate the hydrolytic stability of 10-methacryloyloxydecyl dihydrogen phosphate calcium (MDP-Ca) salts with nanolayered and amorphous structures in different pH environments.Methods: The MDP-Ca salts were synthesized from MDP and calcium chloride and characterized by X-ray diffraction (XRD), nuclear magnetic resonance (NMR), and transmission electron microscopy (TEM). Inductively coupled plasma-mass spectrometry (ICP-MS) was used to quantify the release of calcium from the synthesized MDP-Ca salt, MDP-treated hydroxyapatite (MDP-HAp), and untreated HAp after soaking in acidic and neutral solutions for 1, 7, and 30 days. To study the hydrolytic process, we carried out molecular dynamics (MD) simulations of the nanolayered MCS-MD (monocalcium salt of the MDP dimer) and DCS-MD (dicalcium salt of the MDP dimer) structures, as well as of the amorphous-phase MCS-MM (monocalcium salt of the MDP monomer).Results: The TEM images showed that the nanolayered structures were partially degraded by acid attack. Based on the ICP-MS results, the hydrolysis rate of the MDP-Ca salt in acidic and neutral environments followed the order HAp > MDP-HAp > MDP-Ca salt. The MD simulations showed that, in acidic environments, clusters of MDP remained aggregated and all Ca2+ ions separated from the MDP monomer to interact with water molecules in aqueous solution. In neutral environments, Ca2+ ions always interacted with phosphate groups, OH− ions, and water molecules to form clusters centered on Ca2+ ions.Conclusion: MDP-Ca presented higher hydrolysis rates in acidic than neutral environments. Nanolayered MCS-MD possessed the highest resistance to acidic hydrolysis, followed by amorphous MCS-MM and DCS-MD.Graphical Abstract: Keywords: 10-methacryloyloxydecyl dihydrogen phosphate calcium salts, nanolayering, hydrolysis, molecular dynamics simulations, dentin bonding
Published: 2022

36. Improved Superconducting Properties for Multifilament Graphene-Coated Nb Addition MgB2 Wires by an Internal Mg Diffusion Process

Author: Liu, H. R., Yang, F., Han, F. G., Xie, Z. W., Jin, L. H., Wang, Q. Y., Xiong, X. M., Feng, J. Q., Li, C. S., Li, K. Z., and Zhou, L.
Published: 2022
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37. Task-evoked pupillary responses track precision-weighted prediction errors and learning rate during interceptive visuomotor actions

Author: Harris, D. J., Arthur, T., Vine, S. J., Liu, J., Abd Rahman, H. R., Han, F., and Wilson, M. R.
Published: 2022
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38. Transcriptional Landscape of Enhancer RNAs in Peripheral Blood Mononuclear Cells from Patients with Systemic Lupus Erythematosus

Author: Guo G, Wang H, Tong X, Ye L, Shi X, Fang S, Hu Y, Han F, Chen C, Ding N, Su B, Xue X, and Zhang H
Subjects: enhancer rna (erna), systemic lupus erythematosus (sle), pbmcs, transcription factors (tfs), super-enhancer, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950
Abstract: Gangqiang Guo,1,&ast; Huijing Wang,2,&ast; Xinya Tong,1,&ast; Lele Ye,1 Xinyu Shi,1 Su Fang,1 Ya Hu,3 Fei Han,2 Chaosheng Chen,3 Ning Ding,1 Bofeng Su,3 Xiangyang Xue,1 Huidi Zhang3 1Wenzhou Collaborative Innovation Center of Gastrointestinal Cancer in Basic Research & Precision Medicine, Wenzhou Key Laboratory of Cancer-Related Pathogens & Immunity, Department of Microbiology and Immunology, Institute of Molecular Virology and Immunology, Institute of Tropical Medicine, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, 325035, People’s Republic of China; 2Kidney Disease Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, People’s Republic of China; 3Department of Nephrology, First Affiliated Hospital, Wenzhou Medical University, Wenzhou, 325000, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Bofeng Su; Huidi ZhangDepartment of Nephrology, First Affiliated Hospital, Wenzhou Medical University, Wenzhou, 325000, People’s Republic of China, Email 24449681@qq.com; hd_zhang@163.comObjective: Enhancer RNAs (eRNAs), a class of non-coding RNAs, play indispensable roles in regulating target gene transcription and maintaining cell identity in cooperation with promoters. In this study, we investigated the transcriptional landscape and potential functions of eRNAs in peripheral blood mononuclear cells (PBMCs) from patients with systemic lupus erythematosus (SLE).Methods: PBMCs from five patients with stable SLE, five patients with active SLE, and ten healthy individuals (HCs) were subjected to RNA-sequencing. Putative regulators, differential expression, and pathways were analyzed. eRNAs that were significantly upregulated were first validated by RT-qPCR in 12 samples. Then, candidate eRNAs were confirmed in a validation cohort of 45 samples. We conducted comprehensive pathway analyses to explore the correlations between the candidate eRNAs and SLE pathology.Results: By analyzing eRNA transcript data from PBMCs from SLE patients and HCs, we identified various eRNAs and functional super-enhancers potentially related with SLE. The SLE-specificity of eRNAs seemed to be largely driven by SLE-specific transcription factors (TFs). A Venn diagram of eRNAs differentially expressed in stable, active, and total SLE vs HCs revealed that 13 and 23 eRNAs were commonly upregulated and downregulated, respectively, in patients with stable SLE and those with active SLE. The commonly upregulated eRNAs participate in regulating SLE-related pathways. Only eRNA TCONS_00034326 was significantly (P < 0.05) upregulated in PBMCs of patients with SLE when compared with those of HCs as indicated by RT-qPCR. The area under the receiver-operating curve of TCONS_00034326 for distinguishing SLE patients from HCs was 0.691. Through its putative SLE-related master TF, TCONS_00034326 is involved in multiple SLE-relevant signaling pathways, especially tumor necrosis factor signaling.Conclusion: This study unraveled the transcriptional landscape of eRNAs, eRNA-related TFs, and super-enhancers in PBMCs from SLE patients and HCs. We identified a panel of SLE-relevant eRNAs, providing potential targets in SLE pathogenesis.Keywords: enhancer RNA, eRNA, systemic lupus erythematosus, SLE, PBMCs, transcription factors, TFs, super-enhancer
Published: 2022

39. Efficacy of the Jingxin Zhidong Formula for Tic Disorders: A Randomized, Double Blind, Double Dummy, Parallel Controlled Trial

Author: Fan F, Hao L, Zhang S, Zhang Y, Bian Z, Zhang X, Wang Q, and Han F
Subjects: tic disorder, tourette syndrome, chinese herbal medicine formula, randomized controlled trial, jingxin zhidong formula, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract: Fei Fan,1 Long Hao,2 Si Zhang,1 Ying Zhang,3 Zhaoxiang Bian,4 Xuan Zhang,4 Qiong Wang,5 Fei Han1 1Department of Paediatrics, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, People’s Republic of China; 2Department of Paediatrics, Beijing Fangshan District Liangxiang Hospital, Beijing, People’s Republic of China; 3Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 4Chinese EQUATOR Centre, Hong Kong Chinese Medicine Clinical Study Centre, Chinese Clinical Trial Registry (Hong Kong), School of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hong Kong, People’s Republic of China; 5Clinical Medical School, Beijing University of Chinese Medicine, Beijing, People’s Republic of ChinaCorrespondence: Fei HanDepartment of Paediatrics, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, No. 5, Beixiange Road, Xicheng District, Beijing, 100053, People’s Republic of ChinaTel +86 10-8800 1128Email hf4383@126.comBackground: The Jingxin Zhidong formula (JXZDF), a traditional Chinese medicine, has been widely used to treat tic disorder (TD) in China. However, its efficacy has not yet been evaluated in a randomized controlled trial. We aimed to compare the effectiveness and safety of JXZDF and aripiprazole in patients with TD.Methods: In this randomized, double-blind, double-dummy, parallel controlled trial, 120 patients with TD, aged 6– 16 years were randomly assigned to receive either JXZDF (n = 60, 17.6 g/day) or aripiprazole (n = 60, 10 mg/day) for 12 weeks. The primary outcome was measured using the Yale Global Tic Severity Scale (YGTSS). Adverse events were assessed using the Treatment Emergent Symptom Scale.Results: JXZDF produced greater improvements than aripiprazole in the following YGTSS subscale scores at the endpoint: total tic scores (P = 0.004, 95% CI: 1.085– 3.494) and total motor scores (P = 0.004, 95% CI: 0.313– 1.739). The difference in rate between the groups was no significant (χ2 = 0.702, degrees of freedom = 1, P = 0.402). The overall incidence of adverse events was significantly lower in the JXZDF group than in the aripiprazole group (0% vs 6.67%, P < 0.001).Conclusion: JXZDF had a better safety profile than aripiprazole, and it was not inferior in terms of clinical efficacy. JXZDF warrants consideration as a potential treatment option for TD.Trial Registration: CHiCTR, ChiCTR2000039601 (Registered November 2, 2020).Keywords: tic disorder, Tourette syndrome, Chinese herbal Medicine formula, randomized controlled trial, Jingxin Zhidong formula
Published: 2022

40. Separation of Electron and Hole Dynamics in the Semimetal LaSb

Author: Han, F., Xu, J., Botana, A. S., Xiao, Z. L., Wang, Y. L., Yang, W. G., Chung, D. Y., Kanatzidis, M. G., Norman, M. R., Crabtree, G. W., and Kwok, W. K.
Subjects: Condensed Matter - Materials Science
Abstract: We report investigations on the magnetotransport in LaSb, which exhibits extremely large magnetoresistance (XMR). Foremost, we demonstrate that the resistivity plateau can be explained without invoking topological protection. We then determine the Fermi surface from Shubnikov - de Haas (SdH) quantum oscillation measurements and find good agreement with the bulk Fermi pockets derived from first principle calculations. Using a semiclassical theory and the experimentally determined Fermi pocket anisotropies, we quantitatively describe the orbital magnetoresistance, including its angle dependence. We show that the origin of XMR in LaSb lies in its high mobility with diminishing Hall effect, where the high mobility leads to a strong magnetic field dependence of the longitudinal magnetoconductance. Unlike a one-band material, when a system has two or more bands (Fermi pockets) with electron and hole carriers, the added conductance arising from the Hall effect is reduced, hence revealing the latent XMR enabled by the longitudinal magnetoconductance. With diminishing Hall effect, the magnetoresistivity is simply the inverse of the longitudinal magnetoconductivity, enabling the differentiation of the electron and hole contributions to the XMR, which varies with the strength and orientation of the magnetic field. This work demonstrates a convenient way to separate the dynamics of the charge carriers and to uncover the origin of XMR in multi-band materials with anisotropic Fermi surfaces. Our approach can be readily applied to other XMR materials., Comment: 34 pages, 8 figures
Published: 2017
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41. Superconductivity and multiple pressure-induced phases in BaPt$_2$As$_2$

Author: Guo, C. Y., Jiang, W. B., Smidman, M., Han, F., Malliakas, C. D., Shen, B., Wang, Y. F., Chen, Y., Lu, X., Kanatzidis, M. G., and Yuan, H. Q.
Subjects: Condensed Matter - Superconductivity, Condensed Matter - Strongly Correlated Electrons
Abstract: The newly discovered BaPt$_2$As$_2$ shows a structural distortion at around 275~K, followed by the emergence of superconductivity at lower temperatures. Here we identify the presence of charge density wave (CDW) order at room temperature and ambient pressure using single crystal x-ray diffraction, with both a superlattice and an incommensurate modulation, where there is a change of the superlattice structure below $\simeq$ 275~K. Upon applying pressure, BaPt$_2$As$_2$ shows a rich temperature-pressure phase diagram with multiple pressure-induced transitions at high temperatures, the emergence or disappearance of which are correlated with sudden changes in the superconducting transition temperature $T_c$. These findings demonstrate that BaPt$_2$As$_2$ is a promising new system for studying competing interactions and the relationship between high-temperature electronic instabilities and superconductivity., Comment: 6 pages, 5 figures
Published: 2016
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42. Narcolepsy Quality-of-Life Instrument with 21 Questions: A Translation and Validation Study in Chinese Pediatric Narcoleptics

Author: Li C, Xie L, Shang S, Dong X, Wang X, Zhao L, Zhang C, and Han F
Subjects: narcolepsy, pediatrics, quality of life, validation study, Psychiatry, RC435-571, Neurophysiology and neuropsychology, QP351-495
Abstract: Chenyang Li,1 Liang Xie,2 Shaomei Shang,1 Xiaosong Dong,3 Xiaoling Wang,4 Long Zhao,3 Chi Zhang,3 Fang Han3 1Peking University School of Nursing, Beijing, People’s Republic of China; 2Department of Neurology, The Second Affiliated Hospital of Nanchang University, Nanchang, People’s Republic of China; 3Sleep Medicine Center, Department of Respiratory and Critical Care Medicine, Peking University People’s Hospital, Beijing, People’s Republic of China; 4PKU-UPenn Sleep Center, Peking University International Hospital, Beijing, People’s Republic of ChinaCorrespondence: Fang HanSleep Medicine Center, Department of Respiratory and Critical Care Medicine, Peking University People’s Hospital, Beijing, 100044, People’s Republic of ChinaEmail hanfang1@hotmail.comObjective: This study aimed to translate and validate the narcolepsy quality-of-life instrument with 21 questions (NARQoL-21) in Chinese pediatrics with narcolepsy.Methods: NARQoL-21 was translated following the 10 steps of scale translation. The translated version was tested by exploratory factor analysis (EFA), confirmatory factor analysis (CFA), known-group validity, criterion validity, Cronbach’s α and test-rest reliability.Results: The Chinese version of NARQoL-21 consisted of two factors: (psychosocial factors and future outlook factor), including 20 items. EFA yielded 3 domains for psychosocial factors and 1 domain for future outlook factor. The Chinese version had a negative correlation with the overall Modified Epworth Sleepiness Scale (r = − 0.518, p< 0.001) and meaningful difference in score between drug naïve and treated group (p< 0.05). The Cronbach’s α coefficient was higher than 0.7 and intraclass correlation coefficient (ICC) ranged from 0.75 to 0.905, indicating that it had good reliability.Conclusion: The Chinese version of the NARQoL-21 is available and can be used to evaluate the health-related quality of life (HRQoL) of pediatric narcoleptics, despite that there is a shift in factors compared to the English version due to cultural differences. Future studies are recommended to further validate the scale in Chinese pediatrics with narcolepsy.Keywords: narcolepsy, pediatrics, quality of life, validation study
Published: 2021

43. Cross-Sectional Analysis of the Involvement of Interleukin-17A in Diabetic Retinopathy in Elderly Individuals with Type 2 Diabetes Mellitus

Author: Liu F, Han F, Liu X, Yang L, Jiang C, Cui C, Yuan F, Zhang X, Gong L, Hou X, Liu Y, and Chen L
Subjects: interleukin-17a, diabetic retinopathy, type 2 diabetes mellitus, Specialties of internal medicine, RC581-951
Abstract: Fuqiang Liu,1– 4 Feng Han,4,5 Xiaoli Liu,4,5 Lina Yang,4,5 Caixia Jiang,4,5 Chen Cui,1– 4 Fang Yuan,1– 4 Xin Zhang,1– 4 Lei Gong,1– 4 Xinguo Hou,1– 4 Yuan Liu,1– 4 Li Chen1– 4 1Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, Shandong, 250012, People’s Republic of China; 2Institute of Endocrine and Metabolic Diseases of Shandong University, Jinan, Shandong, 250012, People’s Republic of China; 3Key Laboratory of Endocrine and Metabolic Diseases, Shandong Province Medicine & Health, Jinan, Shandong, 250012, People’s Republic of China; 4Jinan Clinical Research Center for Endocrine and Metabolic Diseases, Jinan, Shandong, 250012, People’s Republic of China; 5Department of Endocrinology, Zhangqiu District People’s Hospital, Jinan, 250200, People’s Republic of ChinaCorrespondence: Yuan Liu; Li Chen Email liuyuan198735@163.com; chenli3@medmail.com.cnBackground: To investigate the correlation between serum interleukin-17A (IL-17A) levels and diabetic retinopathy (DR) in elderly individuals with type 2 diabetes mellitus (T2DM).Methods: The study included 194 elderly patients (94 males and 100 females) with T2DM. Digital retinal photography as well as fundus fluorescein angiography was employed to distinguish between nonproliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy (PDR). In addition, multiple logistic regression analysis was conducted to determine the correlation between serum IL-17A levels and DR status.Results: The average age of the study cohort was 69.14 ± 6.33 years, of which 52.08% were male. The study participants with the highest IL-17A (Q4) levels had higher TC, DBP, and low-density lipoprotein cholesterol (LDL-C) values than those the other groups. Analysis using unadjusted and adjusted linear regression revealed that the effect size of 1.09 for DR in the unadjusted model indicates that IL-17A is associated with an increase of 1.09 in DR (mmol/L) (β 1.09, 95% confidence interval (CI) 1.03, 1.16). Using the minimum-adjusted model (the model 2), as IL-17A increased, DR was higher by 1.11 (β 1.11, 95% CI 1.04, 1.18). With the fully adjusted model (the model 3), for each additional IL-17A increase, DR was higher by 1.15 (β 1.15, 95% CI 1.06, 1.24).Conclusion: Serum IL-17A levels are apparently positively correlated to DR in Chinese elderly individuals with T2DM.Keywords: interleukin-17A, diabetic retinopathy, type 2 diabetes mellitus
Published: 2021

44. Study on adherence to positive airway pressure treatment for patients with obstructive sleep apnea using real-world big data in a telemedicine management system

Author: Yi, H., primary, Shang, S., additional, Zhang, Y., additional, Zhang, C., additional, Xu, L., additional, Wang, J., additional, He, X., additional, Dong, X., additional, and Han, F., additional
Published: 2024
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45. Clinical features, polysomnography, and genetics association study of Restless Legs syndrome in a Chinese population: a multicenter observational study

Author: Zhu, W., primary, Han, F., additional, and Liang, R., additional
Published: 2024
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46. Development and validation of the narcolepsy severity scale in school aged children

Author: Li, C., primary, Spruyt, K., additional, Zhang, C., additional, Xie, L., additional, and Han, F., additional
Published: 2024
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47. A machine learning-based model to predict obstructive sleep apnea in pregnancy

Author: Wang, J., primary and Han, F., additional
Published: 2024
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48. Validation of Alice NightOne for diagnosis of obstructive sleep apnea: a single-belt multi-channel portable monitor with reliability in remote data transmission

Author: Peng, M., primary, Zhang, X., additional, Li, J., additional, Zhao, L., additional, Zhou, B., additional, Zhao, R., additional, Han, F., additional, and Dong, X., additional
Published: 2024
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49. The difference between hypoxic ventilatory response in highlanders and lowlanders with obstructive sleep apnea

Author: Salanitro, M., primary, He, Z.-M., additional, Dong, X.-S., additional, Jiang, X.-L., additional, Zhang, Q.-L., additional, Da, P., additional, Li, J.-P., additional, Shi, J., additional, Han, F., additional, and Penzel, T., additional
Published: 2024
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50. Home monitoring for clinically suspected obstructive sleep apnea in pregnancy

Author: Wang, J., primary, Liu, G., additional, and Han, F., additional
Published: 2024
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