Search

Your search keyword '"Han, Chang-Soo"' showing total 745 results
Start Over Author "Han, Chang-Soo"
745 results on '"Han, Chang-Soo"'

16. Frequency‐Selective, Multi‐Channel, Self‐Powered Artificial Basilar Membrane Sensor with a Spiral Shape and 24 Critical Bands Inspired by the Human Cochlea.

Author

Jeon, Eun‐Seok, Lee, Useung, Yoon, Seongho, Hur, Shin, Choi, Hongsoo, and Han, Chang‐Soo

Subjects
BASILAR membrane, ARTIFICIAL membranes, COCHLEA, POLYIMIDE films, PIEZOELECTRIC detectors, COCHLEA physiology
Abstract

A spiral‐artificial basilar membrane (S‐ABM) sensor is reported that mimics the basilar membrane (BM) of the human cochlea and can detect sound by separating it into 24 sensing channels based on the frequency band. For this, an analytical function is proposed to design the width of the BM so that the frequency bands are linearly located along the length of the BM. To fabricate the S‐ABM sensor, a spiral‐shaped polyimide film is used as a vibrating membrane, with maximum displacement at locations corresponding to specific frequency bands of sound, and attach piezoelectric sensor modules made of poly(vinylidene fluoride‐trifluoroethylene) film on top of the polyimide film to measure the vibration amplitude at each channel location. As the result, the S‐ABM sensor implements a characteristic frequency band of 96‐12,821 Hz and 24‐independent critical bands. Using real‐time signals from discriminate channels, it is demonstrated that the sensor can rapidly identify the operational noises from equipment processes as well as vehicle sounds from environmental noises on the road. The sensor can be used in a variety of applications, including speech recognition, dangerous situation recognition, hearing aids, and cochlear implants, and more. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

40. Inhalable Nano-Dimpled Microspheres Containing Budesonide-PLGA for Improved Aerodynamic Performance

Author

Han,Chang-Soo, Kang,Ji-Hyun, Kim,Young-Jin, Kim,Dong-Wook, Park,Chun-Woong, Han,Chang-Soo, Kang,Ji-Hyun, Kim,Young-Jin, Kim,Dong-Wook, and Park,Chun-Woong

Abstract

Chang-Soo Han,1,* Ji-Hyun Kang,1,* Young-Jin Kim,1 Dong-Wook Kim,2 Chun-Woong Park1 1College of Pharmacy, Chungbuk National University, Cheongju, 28160, Republic of Korea; 2College of Pharmacy, Wonkwang University, Iksan, 54538, Republic of Korea*These authors contributed equally to this workCorrespondence: Chun-Woong Park, College of Pharmacy, Chungbuk National University, 194-21, Osongsangmyeong 1-ro, Heungdeok-gu, Cheongju, Chungbuk, 28160, Republic of Korea, Tel +82-43-261-3330, Fax +82-43-268-2732, Email cwpark@cbnu.ac.krIntroduction: Dry powder inhalations are an attractive pharmaceutical dosage form. They are environmentally friendly, portable, and physicochemical stable compared to other inhalation forms like pressurized metered-dose inhalers and nebulizers. Sufficient drug deposition of DPIs into the deep lung is required to enhance the therapeutic activity. Nanoscale surface roughness in microparticles could improve aerosolization and aerodynamic performance. This study aimed to prepare microspheres with nanoscale dimples and confirm the effect of roughness on inhalation efficiency.Methods: The dimpled-surface on microspheres (MSs) was achieved by oil in water (O/W) emulsion-solvent evaporation by controlling the stirring rate. The physicochemical properties of MSs were characterized. Also, in vitro aerodynamic performance of MSs was evaluated by particle image velocimetry and computational fluid dynamics.Results: The particle image velocimetry results showed that dimpled-surface MSs had better aerosolization, about 20% decreased X-axial velocity, and a variable angle, which could improve the aerodynamic performance. Furthermore, it was confirmed that the dimpled surface of MSs could cause movement away from the bronchial surface, which helps the MSs travel into the deep lung using computational fluid dynamics.Conclusion: The dimpled-surface MSs showed a higher fine particle fraction value compared to smooth-surface MSs in the Ander

Published
2022

Catalog

Books, media, physical & digital resources
See catalog results