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5 results on '"Han, Chan Y."'

1. A game theoretic model for the optimal location of integrated air defense system missile batteries

Author

Han, Chan Y., Lunday, Brian J., and Robbins, Matthew J.

Subjects
Game theory -- Methods, Nonlinear programming -- Methods, Air defenses -- Methods, Antiairborne warfare -- Methods, Combinatorial optimization -- Methods, Computers, Science and technology
Abstract

We examine the optimal location of Integrated Air Defense System (IADS) missile batteries to protect a country's assets, formulated as a Defender-Attacker-Defender three-stage sequential, perfect information, zero-sum game between two [...]

Published
2016
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2. A Game Theoretic Model for the Optimal Disposition of Integrated Air Defense System Assets

Author

Han, Chan Y.

Subjects
game theory, combinatorial optimization, two-person zero-sum games
Abstract

We examine the optimal allocation of Integrated Air Defense System (IADS) resources to protect a country's assets, formulated as a Defender-Attacker-Defender three-stage sequential, perfect information, zero-sum game between two opponents. We formulate a trilevel nonlinear integer program for this Defender-Attacker-Defender model and seek a subgame perfect Nash equilibrium, for which neither the defender nor the attacker has an incentive to deviate from their respective strategies. Such a trilevel formulation is not solvable via conventional optimization software and an exhaustive enumeration of the game tree based on the discrete set of strategies is intractable for large problem sizes. As such, we test and evaluate variants of a tree pruning algorithm and a customized heuristic, which we benchmark against an exhaustive enumeration. Our tests demonstrate that the pruning strategy is not efficient enough to scale up to a larger problem. We then demonstrate the scalability of the heuristic to show that the model can be applied to a realistic size problem.

Published
2015

3. A Game Theoretic Model for the Optimal Disposition of Integrated Air Defense System Assets

Author

AIR FORCE INSTITUTE OF TECHNOLOGY WRIGHT-PATTERSON AFB OH GRADUATE SCHOOL OF ENGINEERING AND MANAGEMENT, Han, Chan Y, AIR FORCE INSTITUTE OF TECHNOLOGY WRIGHT-PATTERSON AFB OH GRADUATE SCHOOL OF ENGINEERING AND MANAGEMENT, and Han, Chan Y

Abstract

We examine the optimal allocation of Integrated Air Defense System (IADS) resources to protect a country's assets, formulated as a Defender-Attacker-Defender three-stage sequential, perfect information, zero-sum game between two opponents. We formulate a trilevel nonlinear integer program for this Defender-Attacker-Defender model and seek a subgame perfect Nash equilibrium, for which neither the defender nor the attacker has an incentive to deviate from their respective strategies. Such a trilevel formulation is not solvable via conventional optimization software and an exhaustive enumeration of the game tree based on the discrete set of strategies is intractable for large problem sizes. As such, we test and evaluate variants of a tree pruning algorithm and a customized heuristic, which we benchmark against an exhaustive enumeration. Our tests demonstrate that the pruning strategy is not e cient enough to scale up to a larger problem. We then demonstrate the scalability of the heuristic to show that the model can be applied to a realistic size problem., The original document contains color images.

Published
2015

5. Antiallergic Effect of the Alpha-Cyclodextrin Moringin Complex in Rat Basophilic Leukaemia (RBL-2H3) Cell Line.

Author

Yousef A Alnakeeb E, Abdull Razis AF, Wei Chan K, Ling Tham C, Han Chan Y, Kalifa Kafo AS, Jambari NN, Rollin P, and Djedaini-Pilard F

Abstract

Allergic diseases (ADs) are a major concern when it comes to public well-being. Moringa oleifera Lam is a tropical plant that is used in traditional medicine due to the presence of isothiocyanate. The present study investigated the antiallergic properties of 4-( α -L-rhamnopyranosyloxy)-benzyl isothiocyanate or moringin isolated from Moringa oleifera seeds in the form of alpha-cyclodextrin-moringin ( α -CD/MG) complex on rat basophilic leukaemia (RBL-2H3) cell line at both the early and late stages of an allergic reaction. The α -CD/MG complex was initially elucidated using nuclear magnetic resonance (NMR) followed by the 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium inner salt proliferation assay to evaluate the cytotoxicity and cell viability with respect to ketotifen fumarate (KF) and α -CD/MG. The release of beta-hexosaminidase ( β -hexosaminidase) and histamine was used to determine the level of inhibition in the early stage while the suppression of the release of prostaglandin (PGD2), tumour necrosis factor-alpha (TNF- α ), and interleukin (IL-4) was considered in the late stage. Higher concentrations of α -CD/MG (5  μ M, p < 0.001) in mast cell degranulation significantly inhibited the expression of β -hexosaminidase, histamine, TNF- α , PGD2, and IL-4 in both the early and late stages. Thus, α -CD/MG can potentially be developed as an antiallergic drug as it has the ability to inhibit allergic responses in the late and early stages., Competing Interests: The authors declare that there are no conflicts of interest regarding the publication of this paper., (Copyright © 2024 Ebtisam Yousef A. Alnakeeb et al.)

Published
2024
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