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200 results on '"Han, Byoung Geun"'

19. Comparative efficacy and safety of gemigliptin versus linagliptin in type 2 diabetes patients with renal impairment: A 40‐week extension of the GUARD randomized study

Author

Han, Sang Youb, Yoon, Sun Ae, Han, Byoung Geun, Kim, Sung Gyun, Jo, Young‐Il, Jeong, Kyung Hwan, Oh, Kook‐Hwan, Park, Hyeong Cheon, Park, Sun‐Hee, Kang, Shin‐Wook, Na, Ki‐Ryang, Kang, Sun Woo, Kim, Nam‐Ho, Jang, Younghwan, Kim, Bogyeong, Shin, Seonghye, and Cha, Dae Ryong

Published
2018
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23. Markers of glycemic control in the mouse: comparisons of 6-h- and overnight-fasted blood glucoses to Hb [A.sub.1c]

Author

Han, Byoung Geun, Hao, Chuan-Ming, Tchekneva, Elena E., Wang, Ying-Ying, Lee, Chieh Allen, Ebrahim, Benyamin, Harris, Raymond C., Kern, Timothy S., Wasserman, David H., Breyer, Matthew D., and Qi, Zhonghua

Subjects
Glycosylated hemoglobin -- Properties, Glycemic index -- Measurement, Biological markers -- Identification and classification, Physiological research, Biological sciences
Abstract

The present studies examined the relationship between fasting blood glucose and Hb [A.sub.1c] in C57BL/6J, DBA/2J, and KK/H1J mice with and without diabetes mellitus. Daily averaged blood glucose levels based on continuous glucose monitoring and effects of 6-h vs. overnight fasting on blood glucose were determined. Daily averaged blood glucose levels were highly correlated with Hb [A.sub.1c], as determined with a hand-held automated device using an immunodetection method. [R.sup.2] values were 0.90, 0.95, and 0.99 in KK/HIJ, C57BL/6J, and DBA/2J, respectively. Six-hour fasting blood glucose correlated more closely with the level of daily averaged blood glucose and with Hb [[A.sub.1c] than did blood glucose following an overnight fast. To validate the immunoassay-determined Hb [A.sub.1c], we also measured total glycosylated hemoglobin using boronate HPLC. Hb [A.sub.1c] values correlated well with total glycosylated hemoglobin in all three strains but were relatively lower than total glycosylated hemoglobin in diabetic DBA/2J mice. These results show that 6-h fasting glucose provides a superior index of glycemic control and correlates more closely with Hb [A.sub.1c] than overnight-fasted blood glucose in these strains of mice. glycosylated hemoglobin; methodology; mice

Published
2008

24. PODOCYTE-SPECIFIC OVEREXPRESSION OF SIRT-1 INCREASES NEPHRIN IN OBESE MICE FED A HIGH-FAT DIET

Author

Han Byoung-Geun, Cui Jun, Yang Jae-Won, and Choi Seung-Ok

Subjects
Internal medicine, RC31-1245, Specialties of internal medicine, RC581-951
Abstract

Obesity can lead to inflammation, hyperlipidemia, diabetes, hypertension, and renal dysfunction, and is also associated with proteinuria. Histopathological changes in the glomeruli in obesity were characterized by glomerulomegaly and focal segmental glomerulosclerosis. This study was designed to investigate the effect of sirtuin 1 (SIRT-1), podocyte-specific overexpressed, on nephrin levels in obese mice induced by high fat diet. SIRT-1 has been proposed as a chemotherapeutic target for type II diabetes mellitus. After establishing the SIRT-1 transgenic mice, experimental groups were divided into following three groups: Normal diet-normal group (ND-NL), high fat diet-normal group (HFD-NL), and high fat diet-SIRT-1 group (HFD-SIRT1). The background of transgenic mice was C57BL/6. High fat diet group were fed with a high calorie diet (60%) for up to 21 weeks to examine a progressive development of obesity. Body weight, 6 hours fasting blood glucose, and HbA1c were regularly measured. Albumin-Creatinine Ratio (ACR) in 24 hours urine was measured 21 weeks after the experiment. The expression levels of SIRT-1 and nephrin in the kidney by using western-blot and RT-PCR were compared. With repeated measures ANOVA test, both high fat diet groups were showing that the body weight was significantly higher than normal diet group (P

Published
2012
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34. Association of impedance ratio with corrected Geriatric Nutritional Risk Index in older patients with nondialysis chronic kidney disease stage 5.

Author

Han, Byoung‐Geun, Han, Jihye, and Lee, Kwang Hoon

Subjects
OLDER patients, CHRONIC kidney failure, DISEASE progression, BODY mass index, WATER-electrolyte balance (Physiology), RESEARCH, MULTIPLE regression analysis, REGRESSION analysis, DIET therapy, BIOELECTRIC impedance, MASS spectrometry, DESCRIPTIVE statistics, MALNUTRITION, STATISTICAL correlation, ELDER care, OLD age
Abstract

Background: The usual calculation of body mass index (BMI) can be misleading in patients with advanced chronic kidney disease (CKD) because their altered fluid balances may not be reflected. We obtained corrected BMI (cBMI) and corrected Geriatric Nutritional Risk Index (cGNRI) values and investigated whether the impedance ratio (IR) of 200/5 kHz, measured using bioimpedance spectroscopy, was associated with cGNRI in older patients with nondialysis CKD stage 5 (CKD5‐ND). Methods: Patients over 65 years old (n = 118) were divided into groups by cGNRI tertiles. The differences between the correlations were tested using Steiger's z‐test. The IR and cBMI were used as both continuous and categorical variables in the regression analyses to determine the factors that were independently associated with the cGNRI. Results: Patients in the third cGNRI tertile had a significantly lower mean IR than those in the other 2 tertiles (P <.001). Across the 3 cGNRI tertile groups, the IR was incrementally lower in the higher cGNRI tertiles (P for trend <.001). The Steiger's z‐test showed that the IR had a significantly stronger correlation with cGNRI than cBMI had with cGNRI. In the multivariable linear regression analyses, the IR was independently associated with the cGNRI, after adjusting for various confounders. Conclusion: The current results revealed that the IR was a more sensitive indicator of nutrition risk than BMI and was independently associated with cGNRI in older patients with CKD5‐ND. Our study suggests that the IR is an appropriate tool for nutrition risk screening. [ABSTRACT FROM AUTHOR]

Published
2022
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50. Secondary Focal Segmental Glomerulosclerosis: From Podocyte Injury to Glomerulosclerosis

Author

Kim, Jae Seok, Han, Byoung Geun, Choi, Seung Ok, and Cha, Seung-Kuy

Subjects
Article Subject, urogenital system, urologic and male genital diseases, female genital diseases and pregnancy complications
Abstract

Focal segmental glomerulosclerosis (FSGS) is a common cause of proteinuria and nephrotic syndrome leading to end stage renal disease (ESRD). There are two types of FSGS, primary (idiopathic) and secondary forms. Secondary FSGS shows less severe clinical features compared to those of the primary one. However, secondary FSGS has an important clinical significance because a variety of renal diseases progress to ESRD thorough the form of secondary FSGS. The defining feature of FSGS is proteinuria. The key event of FSGS is podocyte injury which is caused by multiple factors. Unanswered questions about how these factors act on podocytes to cause secondary FSGS are various and ill-defined. In this review, we provide brief overview and new insights into FSGS, podocyte injury, and their potential linkage suggesting clues to answer for treatment of the disease.

Published
2016
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