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299 results on '"Hammond, Sue"'

2. Non-fiction

Author

Mowbray, Trevor and Hammond, Sue

Published
1990

3. Somatic and Germline TP53 Alterations in Second Malignant Neoplasms from Pediatric Cancer Survivors.

Author

Sherborne, Amy L, Lavergne, Vincent, Yu, Katharine, Lee, Leah, Davidson, Philip R, Mazor, Tali, Smirnoff, Ivan V, Horvai, Andrew E, Loh, Mignon, DuBois, Steven G, Goldsby, Robert E, Neglia, Joseph P, Hammond, Sue, Robison, Leslie L, Wustrack, Rosanna, Costello, Joseph F, Nakamura, Alice O, Shannon, Kevin M, Bhatia, Smita, and Nakamura, Jean L

Subjects
Humans, Neoplasms, Neoplasms, Second Primary, Genetic Predisposition to Disease, Pediatrics, Loss of Heterozygosity, Germ-Line Mutation, Polymorphism, Single Nucleotide, Adolescent, Child, Male, Tumor Suppressor Protein p53, Cancer Survivors, Exome Sequencing, Clinical Research, Cancer, Rare Diseases, Human Genome, Pediatric, Genetics, Pediatric Cancer, Aetiology, 2.1 Biological and endogenous factors, Good Health and Well Being, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

Purpose: Second malignant neoplasms (SMNs) are severe late complications that occur in pediatric cancer survivors exposed to radiotherapy and other genotoxic treatments. To characterize the mutational landscape of treatment-induced sarcomas and to identify candidate SMN-predisposing variants, we analyzed germline and SMN samples from pediatric cancer survivors.Experimental Design: We performed whole-exome sequencing (WES) and RNA sequencing on radiation-induced sarcomas arising from two pediatric cancer survivors. To assess the frequency of germline TP53 variants in SMNs, Sanger sequencing was performed to analyze germline TP53 in 37 pediatric cancer survivors from the Childhood Cancer Survivor Study (CCSS) without any history of a familial cancer predisposition syndrome but known to have developed SMNs.Results: WES revealed TP53 mutations involving p53's DNA-binding domain in both index cases, one of which was also present in the germline. The germline and somatic TP53-mutant variants were enriched in the transcriptomes for both sarcomas. Analysis of TP53-coding exons in germline specimens from the CCSS survivor cohort identified a G215C variant encoding an R72P amino acid substitution in 6 patients and a synonymous SNP A639G in 4 others, resulting in 10 of 37 evaluable patients (27%) harboring a germline TP53 variant.Conclusions: Currently, germline TP53 is not routinely assessed in patients with pediatric cancer. These data support the concept that identifying germline TP53 variants at the time a primary cancer is diagnosed may identify patients at high risk for SMN development, who could benefit from modified therapeutic strategies and/or intensive posttreatment monitoring. Clin Cancer Res; 23(7); 1852-61. ©2016 AACR.

Published
2017

7. Data from Somatic and Germline TP53 Alterations in Second Malignant Neoplasms from Pediatric Cancer Survivors

Author

Sherborne, Amy L., primary, Lavergne, Vincent, primary, Yu, Katharine, primary, Lee, Leah, primary, Davidson, Philip R., primary, Mazor, Tali, primary, Smirnoff, Ivan V., primary, Horvai, Andrew E., primary, Loh, Mignon, primary, DuBois, Steven G., primary, Goldsby, Robert E., primary, Neglia, Joseph P., primary, Hammond, Sue, primary, Robison, Leslie L., primary, Wustrack, Rosanna, primary, Costello, Joseph F., primary, Nakamura, Alice O., primary, Shannon, Kevin M., primary, Bhatia, Smita, primary, and Nakamura, Jean L., primary

Published
2023
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8. Supplementary Table 1 from Somatic and Germline TP53 Alterations in Second Malignant Neoplasms from Pediatric Cancer Survivors

Author

Sherborne, Amy L., primary, Lavergne, Vincent, primary, Yu, Katharine, primary, Lee, Leah, primary, Davidson, Philip R., primary, Mazor, Tali, primary, Smirnoff, Ivan V., primary, Horvai, Andrew E., primary, Loh, Mignon, primary, DuBois, Steven G., primary, Goldsby, Robert E., primary, Neglia, Joseph P., primary, Hammond, Sue, primary, Robison, Leslie L., primary, Wustrack, Rosanna, primary, Costello, Joseph F., primary, Nakamura, Alice O., primary, Shannon, Kevin M., primary, Bhatia, Smita, primary, and Nakamura, Jean L., primary

Published
2023
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9. Supplementary Figure 1 from Somatic and Germline TP53 Alterations in Second Malignant Neoplasms from Pediatric Cancer Survivors

Author

Sherborne, Amy L., primary, Lavergne, Vincent, primary, Yu, Katharine, primary, Lee, Leah, primary, Davidson, Philip R., primary, Mazor, Tali, primary, Smirnoff, Ivan V., primary, Horvai, Andrew E., primary, Loh, Mignon, primary, DuBois, Steven G., primary, Goldsby, Robert E., primary, Neglia, Joseph P., primary, Hammond, Sue, primary, Robison, Leslie L., primary, Wustrack, Rosanna, primary, Costello, Joseph F., primary, Nakamura, Alice O., primary, Shannon, Kevin M., primary, Bhatia, Smita, primary, and Nakamura, Jean L., primary

Published
2023
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10. Supplementary Files from Somatic and Germline TP53 Alterations in Second Malignant Neoplasms from Pediatric Cancer Survivors

Author

Sherborne, Amy L., primary, Lavergne, Vincent, primary, Yu, Katharine, primary, Lee, Leah, primary, Davidson, Philip R., primary, Mazor, Tali, primary, Smirnoff, Ivan V., primary, Horvai, Andrew E., primary, Loh, Mignon, primary, DuBois, Steven G., primary, Goldsby, Robert E., primary, Neglia, Joseph P., primary, Hammond, Sue, primary, Robison, Leslie L., primary, Wustrack, Rosanna, primary, Costello, Joseph F., primary, Nakamura, Alice O., primary, Shannon, Kevin M., primary, Bhatia, Smita, primary, and Nakamura, Jean L., primary

Published
2023
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11. Data from FANCD2 Is a Potential Therapeutic Target and Biomarker in Alveolar Rhabdomyosarcoma Harboring the PAX3–FOXO1 Fusion Gene

Author

Singh, Mamata, primary, Leasure, Justin M., primary, Chronowski, Christopher, primary, Geier, Brian, primary, Bondra, Kathryn, primary, Duan, Wenrui, primary, Hensley, Lauren A., primary, Villalona-Calero, Miguel, primary, Li, Ning, primary, Vergis, Anthony M., primary, Kurmasheva, Raushan T., primary, Shen, Changxian, primary, Woods, Gary, primary, Sebastian, Nikhil, primary, Fabian, Denise, primary, Kaplon, Rita, primary, Hammond, Sue, primary, Palanichamy, Kamalakannan, primary, Chakravarti, Arnab, primary, and Houghton, Peter J., primary

Published
2023
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12. Supplementary Legend from Somatic and Germline TP53 Alterations in Second Malignant Neoplasms from Pediatric Cancer Survivors

Author

Sherborne, Amy L., primary, Lavergne, Vincent, primary, Yu, Katharine, primary, Lee, Leah, primary, Davidson, Philip R., primary, Mazor, Tali, primary, Smirnoff, Ivan V., primary, Horvai, Andrew E., primary, Loh, Mignon, primary, DuBois, Steven G., primary, Goldsby, Robert E., primary, Neglia, Joseph P., primary, Hammond, Sue, primary, Robison, Leslie L., primary, Wustrack, Rosanna, primary, Costello, Joseph F., primary, Nakamura, Alice O., primary, Shannon, Kevin M., primary, Bhatia, Smita, primary, and Nakamura, Jean L., primary

Published
2023
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13. Supplementary Figure 3 from Somatic and Germline TP53 Alterations in Second Malignant Neoplasms from Pediatric Cancer Survivors

Author

Sherborne, Amy L., primary, Lavergne, Vincent, primary, Yu, Katharine, primary, Lee, Leah, primary, Davidson, Philip R., primary, Mazor, Tali, primary, Smirnoff, Ivan V., primary, Horvai, Andrew E., primary, Loh, Mignon, primary, DuBois, Steven G., primary, Goldsby, Robert E., primary, Neglia, Joseph P., primary, Hammond, Sue, primary, Robison, Leslie L., primary, Wustrack, Rosanna, primary, Costello, Joseph F., primary, Nakamura, Alice O., primary, Shannon, Kevin M., primary, Bhatia, Smita, primary, and Nakamura, Jean L., primary

Published
2023
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14. Data from Chemotherapy and Thyroid Cancer Risk: A Report from the Childhood Cancer Survivor Study

Author

Veiga, Lene H.S., primary, Bhatti, Parveen, primary, Ronckers, Cécile M., primary, Sigurdson, Alice J., primary, Stovall, Marilyn, primary, Smith, Susan A., primary, Weathers, Rita, primary, Leisenring, Wendy, primary, Mertens, Ann C., primary, Hammond, Sue, primary, Neglia, Joseph P., primary, Meadows, Anna T., primary, Donaldson, Sarah S., primary, Sklar, Charles A., primary, Friedman, Debra L., primary, Robison, Leslie L., primary, and Inskip, Peter D., primary

Published
2023
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15. Supplementary Figure 4 from Somatic and Germline TP53 Alterations in Second Malignant Neoplasms from Pediatric Cancer Survivors

Author

Sherborne, Amy L., primary, Lavergne, Vincent, primary, Yu, Katharine, primary, Lee, Leah, primary, Davidson, Philip R., primary, Mazor, Tali, primary, Smirnoff, Ivan V., primary, Horvai, Andrew E., primary, Loh, Mignon, primary, DuBois, Steven G., primary, Goldsby, Robert E., primary, Neglia, Joseph P., primary, Hammond, Sue, primary, Robison, Leslie L., primary, Wustrack, Rosanna, primary, Costello, Joseph F., primary, Nakamura, Alice O., primary, Shannon, Kevin M., primary, Bhatia, Smita, primary, and Nakamura, Jean L., primary

Published
2023
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16. Supplementary Figure 1 from FANCD2 Is a Potential Therapeutic Target and Biomarker in Alveolar Rhabdomyosarcoma Harboring the PAX3–FOXO1 Fusion Gene

Author

Singh, Mamata, primary, Leasure, Justin M., primary, Chronowski, Christopher, primary, Geier, Brian, primary, Bondra, Kathryn, primary, Duan, Wenrui, primary, Hensley, Lauren A., primary, Villalona-Calero, Miguel, primary, Li, Ning, primary, Vergis, Anthony M., primary, Kurmasheva, Raushan T., primary, Shen, Changxian, primary, Woods, Gary, primary, Sebastian, Nikhil, primary, Fabian, Denise, primary, Kaplon, Rita, primary, Hammond, Sue, primary, Palanichamy, Kamalakannan, primary, Chakravarti, Arnab, primary, and Houghton, Peter J., primary

Published
2023
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17. Supplementary Figure 3 from FANCD2 Is a Potential Therapeutic Target and Biomarker in Alveolar Rhabdomyosarcoma Harboring the PAX3–FOXO1 Fusion Gene

Author

Singh, Mamata, primary, Leasure, Justin M., primary, Chronowski, Christopher, primary, Geier, Brian, primary, Bondra, Kathryn, primary, Duan, Wenrui, primary, Hensley, Lauren A., primary, Villalona-Calero, Miguel, primary, Li, Ning, primary, Vergis, Anthony M., primary, Kurmasheva, Raushan T., primary, Shen, Changxian, primary, Woods, Gary, primary, Sebastian, Nikhil, primary, Fabian, Denise, primary, Kaplon, Rita, primary, Hammond, Sue, primary, Palanichamy, Kamalakannan, primary, Chakravarti, Arnab, primary, and Houghton, Peter J., primary

Published
2023
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18. Supplementary Figure Legends from FANCD2 Is a Potential Therapeutic Target and Biomarker in Alveolar Rhabdomyosarcoma Harboring the PAX3–FOXO1 Fusion Gene

Author

Singh, Mamata, primary, Leasure, Justin M., primary, Chronowski, Christopher, primary, Geier, Brian, primary, Bondra, Kathryn, primary, Duan, Wenrui, primary, Hensley, Lauren A., primary, Villalona-Calero, Miguel, primary, Li, Ning, primary, Vergis, Anthony M., primary, Kurmasheva, Raushan T., primary, Shen, Changxian, primary, Woods, Gary, primary, Sebastian, Nikhil, primary, Fabian, Denise, primary, Kaplon, Rita, primary, Hammond, Sue, primary, Palanichamy, Kamalakannan, primary, Chakravarti, Arnab, primary, and Houghton, Peter J., primary

Published
2023
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19. Supplementary Figure 5 from Somatic and Germline TP53 Alterations in Second Malignant Neoplasms from Pediatric Cancer Survivors

Author

Sherborne, Amy L., primary, Lavergne, Vincent, primary, Yu, Katharine, primary, Lee, Leah, primary, Davidson, Philip R., primary, Mazor, Tali, primary, Smirnoff, Ivan V., primary, Horvai, Andrew E., primary, Loh, Mignon, primary, DuBois, Steven G., primary, Goldsby, Robert E., primary, Neglia, Joseph P., primary, Hammond, Sue, primary, Robison, Leslie L., primary, Wustrack, Rosanna, primary, Costello, Joseph F., primary, Nakamura, Alice O., primary, Shannon, Kevin M., primary, Bhatia, Smita, primary, and Nakamura, Jean L., primary

Published
2023
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20. Supplementary Figure 2 from Somatic and Germline TP53 Alterations in Second Malignant Neoplasms from Pediatric Cancer Survivors

Author

Sherborne, Amy L., primary, Lavergne, Vincent, primary, Yu, Katharine, primary, Lee, Leah, primary, Davidson, Philip R., primary, Mazor, Tali, primary, Smirnoff, Ivan V., primary, Horvai, Andrew E., primary, Loh, Mignon, primary, DuBois, Steven G., primary, Goldsby, Robert E., primary, Neglia, Joseph P., primary, Hammond, Sue, primary, Robison, Leslie L., primary, Wustrack, Rosanna, primary, Costello, Joseph F., primary, Nakamura, Alice O., primary, Shannon, Kevin M., primary, Bhatia, Smita, primary, and Nakamura, Jean L., primary

Published
2023
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21. Supplementary Figure 2 from FANCD2 Is a Potential Therapeutic Target and Biomarker in Alveolar Rhabdomyosarcoma Harboring the PAX3–FOXO1 Fusion Gene

Author

Singh, Mamata, primary, Leasure, Justin M., primary, Chronowski, Christopher, primary, Geier, Brian, primary, Bondra, Kathryn, primary, Duan, Wenrui, primary, Hensley, Lauren A., primary, Villalona-Calero, Miguel, primary, Li, Ning, primary, Vergis, Anthony M., primary, Kurmasheva, Raushan T., primary, Shen, Changxian, primary, Woods, Gary, primary, Sebastian, Nikhil, primary, Fabian, Denise, primary, Kaplon, Rita, primary, Hammond, Sue, primary, Palanichamy, Kamalakannan, primary, Chakravarti, Arnab, primary, and Houghton, Peter J., primary

Published
2023
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22. Supplementary Tables 1-2 from Chemotherapy and Thyroid Cancer Risk: A Report from the Childhood Cancer Survivor Study

Author

Veiga, Lene H.S., primary, Bhatti, Parveen, primary, Ronckers, Cécile M., primary, Sigurdson, Alice J., primary, Stovall, Marilyn, primary, Smith, Susan A., primary, Weathers, Rita, primary, Leisenring, Wendy, primary, Mertens, Ann C., primary, Hammond, Sue, primary, Neglia, Joseph P., primary, Meadows, Anna T., primary, Donaldson, Sarah S., primary, Sklar, Charles A., primary, Friedman, Debra L., primary, Robison, Leslie L., primary, and Inskip, Peter D., primary

Published
2023
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23. Supplementary Tables 1 - 4 from FANCD2 Is a Potential Therapeutic Target and Biomarker in Alveolar Rhabdomyosarcoma Harboring the PAX3–FOXO1 Fusion Gene

Author

Singh, Mamata, primary, Leasure, Justin M., primary, Chronowski, Christopher, primary, Geier, Brian, primary, Bondra, Kathryn, primary, Duan, Wenrui, primary, Hensley, Lauren A., primary, Villalona-Calero, Miguel, primary, Li, Ning, primary, Vergis, Anthony M., primary, Kurmasheva, Raushan T., primary, Shen, Changxian, primary, Woods, Gary, primary, Sebastian, Nikhil, primary, Fabian, Denise, primary, Kaplon, Rita, primary, Hammond, Sue, primary, Palanichamy, Kamalakannan, primary, Chakravarti, Arnab, primary, and Houghton, Peter J., primary

Published
2023
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24. Radiation-Related New Primary Solid Cancers in the Childhood Cancer Survivor Study: Comparative Radiation Dose Response and Modification of Treatment Effects

Author

Inskip, Peter D., Sigurdson, Alice J., Veiga, Lene, Bhatti, Parveen, Ronckers, Cécile, Rajaraman, Preetha, Boukheris, Houda, Stovall, Marilyn, Smith, Susan, Hammond, Sue, Henderson, Tara O., Watt, Tanya C., Mertens, Ann C., Leisenring, Wendy, Stratton, Kayla, Whitton, John, Donaldson, Sarah S., Armstrong, Gregory T., Robison, Leslie L., and Neglia, Joseph P.

Published
2016
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25. Towards Mentoring as Feminist Praxis in Early Childhood Education and Care in England

Author

Hammond, Sue, Powell, Sacha, and Smith, Kate

Abstract

Following our contribution to a study of mentoring in seven European countries, we explored epistemological and ontological inconsistencies within mainstream mentoring systems and their regulated practice in England. We considered how feminist mentoring praxis can unsettle conceptualisations of mentoring relationships and challenge inequity in the early education systems and the practice of teaching young children. Predominantly female, early childhood educators suffer from low status in England, and their working lives may be controlled and policed through inequitable systems. On entering the workforce, trainees encounter a reductionist policy milieu where mentoring structures and normative assessment arrangements contribute to inequity. Mentors play pivotal roles in inducting trainees into their worlds of work with young children. Mentoring relationships can determine whether trainees accept the status quo. Principles derived from feminist praxis enable mentors to practise an "engaged pedagogy", co-constructing knowledge, subverting hierarchies and contesting taken-for-granted aspects of policy and practice.

Published
2015
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26. Genome-Wide Association Study to Identify Susceptibility Loci That Modify Radiation-Related Risk for Breast Cancer After Childhood Cancer

Author

Morton, Lindsay M., Sampson, Joshua N., Armstrong, Gregory T., Chen, Ting-Huei, Hudson, Melissa M., Karlins, Eric, Dagnall, Casey L., Li, Shengchao Alfred, Wilson, Carmen L., Srivastava, Deo Kumar, Liu, Wei, Kang, Guolian, Oeffinger, Kevin C., Henderson, Tara O., Moskowitz, Chaya S., Gibson, Todd M., Merino, Diana M., Wong, Jeannette R., Hammond, Sue, Neglia, Joseph P., Turcotte, Lucie M., Miller, Jeremy, Bowen, Laura, Wheeler, William A., Leisenring, Wendy M., Whitton, John A., Burdette, Laurie, Chung, Charles, Hicks, Belynda D., Jones, Kristine, Machiela, Mitchell J., Vogt, Aurelie, Wang, Zhaoming, Yeager, Meredith, Neale, Geoffrey, Lear, Matthew, Strong, Louise C., Yasui, Yutaka, Stovall, Marilyn, Weathers, Rita E., Smith, Susan A., Howell, Rebecca, Davies, Stella M., Radloff, Gretchen A., Onel, Kenan, de González, Amy Berrington, Inskip, Peter D., Rajaraman, Preetha, Fraumeni, Joseph F., Jr., Bhatia, Smita, Chanock, Stephen J., Tucker, Margaret A., and Robison, Leslie L.

Published
2017
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29. Wild Woods or Urban Jungle: Playing It Safe or Freedom to Roam

Author

Hope, Gill, Austin, Rebecca, Dismore, Harriet, Hammond, Sue, and Whyte, Terry

Abstract

The rationale and focus for this paper is a discussion from five perspectives on the issues surrounding childhood freedoms and levels of physical activity. From our different perspectives we argue that beneath these very real and proper concerns that parents have for their children's safety are societal concerns and perceptions concerning the nature of childhood within contemporary English society. The knock-on effects for children, in terms of physical, emotional, social and creative development are the issues that the paper seeks to raise. Writing this paper together has enabled the continuation and extension of an on-going discussion between the five authors.

Published
2007
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32. Risk of Second Primary Thyroid Cancer after Radiotherapy for a Childhood Cancer in a Large Cohort Study: An Update from the Childhood Cancer Survivor Study

Author

Bhatti, Parveen, Veiga, Lene H. S., Ronckers, Cécile M., Sigurdson, Alice J., Stovall, Marilyn, Smith, Susan A., Weathers, Rita, Leisenring, Wendy, Mertens, Ann C., Hammond, Sue, Friedman, Debra L., Neglia, Joseph P., Meadows, Anna T., Donaldson, Sarah S., Sklar, Charles A., Robison, Leslie L., and Inskip, Peter D.

Published
2010

33. Healthy Later Living in a time of COVID.:CASP Policy Labs:Executive Summary

Author

Forrester-Jones, Rachel, Randall, Amy, Postle Hammond, Sue, Hammond, Mark, Jawad, Rana, and Smith, Paula

Abstract

The CASP project’s aim was to develop a University of Bath (UoB) Humanities and Social Sciences (HSS) Faculty wide Policy Lab (PL) initiative to approach policy issues using innovative design orientated methods.The UoB is also committed to engaging locally to ensure maximum benefits of their research can be shared and applied to local community issues and activities. Building on the small number of existing PL models in UK public policy settings, the project sought to enhance these new approaches in two key ways:• first by building capacity and capability through the Centre for the Analysis ofSocial Policy (CASP) in the HSS which would have a regional and local basis; and• second by involving service users by experience (including carers) in the PLsessions, which has not been a feature of initiatives such as the UK CabinetOffice PL programme.Policy Labs (PLs) were planned for three administrative areas within the West of England Combined Authorities Area (WECA). These are Bath and North East Somerset (BaNES), Bristol and South Gloucestershire (S Gloucestershire). A final Regional PL was held for the whole WECA area to discuss feedback from the local PLs and future plans. The topic for the PLs was Healthy Ageing (subsequently retitled to Healthy Later Living) which also ties in well with the UoB Healthy Later Living campaign and network.The process of building the PL team, designing the events and developing the networks and contacts to support the events was established and the first PL for BaNES was held in March 2020. The findings from this event assisted the project to enhance the understanding of best practice on PLs, and lessons learned from the first event were included in planning for the next two PLs for Bristol and S Gloucestershire. These two PLs were held in March 2021 since the intervention of the COVID-19 (Covid) pandemic prevented the project from delivering all events as planned in 2020. The Covid pandemic has had a significant impact for carers and older people and the second two PLs have addressed the issues raised by the pandemic in relation to healthy later living.The project was funded by the UK Research and Innovation (UKRI) programme through the UoB. Full description of the process and issues from the PLs are described in more comprehensive reports submitted to the UoB, which include details of the presentations and discussions for the PLs. This document provides a summary of the key findings and conclusions of the PLs, including a critique of the PL process used in the project. And how it might be taken forward.

Published
2021

37. Primary thyroid cancer after a first tumour in childhood (the Childhood Cancer Survivor Study): a nested case-control study

Author

Sigurdson, Alice J., Ronckers, Cecile M., Mertens, Ann C., Stovall, Marilyn, Smith, Susan A., Liu, Yan, Berkow, Roger L., Hammond, Sue, Neglia, Joseph P., Meadows, Anna T., Sklar, Charles A., Robison, Leslie L., and Inskip, Peter D.

Subjects
Children's Hospital of Philadelphia -- Services, Thyroid cancer -- Case studies, Children -- Health aspects
Published
2005

41. Secondary Gastrointestinal Cancer in Childhood Cancer Survivors: A Cohort Study

Author

Henderson, Tara O., Oeffinger, Kevin C., Whitton, John, Leisenring, Wendy, Neglia, Joseph, Meadows, Anna, Crotty, Catherine, Rubin, David T., Diller, Lisa, Inskip, Peter, Smith, Susan A., Stovall, Marilyn, Constine, Louis S., Hammond, Sue, Armstrong, Greg T., Robison, Leslie L., and Nathan, Paul C.

Published
2012

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