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1. Dinler Tarihinde Bir Mukayese Örneği: G. Parrinder’in Bakış Açısıyla Avatara ve Enkarnasyon/A Comparative Case in the History of Religions: Avatara and Incarnation from G. Parrinder’s Point of View

Author

Hammet Arslan

Subjects
avatara, enkarnasyon, hinduizm, hıristiyanlık, Philosophy of religion. Psychology of religion. Religion in relation to other subjects, BL51-65
Abstract

The comparative method is a research method that is frequently applied in the field of History of Religions. Thanks to this method, similarities and differences between beliefs and practices of different religions can be revealed. Besides, semantic changes of some terms in different religions can be determined. In this regard, the case of avatara and incarnation doctrines, which contain a number of similarities and differences, is an important example. In this article, from G. Parrinder's point of view, we will try to put forward the claims of similarities and differences between the Indians' doctrine of avatara and the Christians’ doctrine of the incarnation.

Published
2019
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2. Vγ9Vδ2 T cells recognize butyrophilin 2A1 and 3A1 heteromers

Author

Fulford, Thomas S., Soliman, Caroline, Castle, Rebecca G., Rigau, Marc, Ruan, Zheng, Dolezal, Olan, Seneviratna, Rebecca, Brown, Hamish G., Hanssen, Eric, Hammet, Andrew, Li, Shihan, Redmond, Samuel J., Chung, Amy, Gorman, Michael A., Parker, Michael W., Patel, Onisha, Peat, Thomas S., Newman, Janet, Behren, Andreas, Gherardin, Nicholas A., Godfrey, Dale I., and Uldrich, Adam P.

Published
2024
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3. Evaluation of Female Cases Applying to Mersin Medical Faculty Hospital Due to Partner Violence Between 2018-2020

Author

Hammet Işık and Nursel Gamsız Bilgin

Subjects
medicolegal evaluation, partner violence, physical violence against women, Medicine (General), R5-920
Abstract

Objective:It is aimed to medicolegal evaluation of risk factors and to discuss in the light of literature, depending on sociodemographic data, causes of violence and physical/mental pathologies in women who were sent to the Forensic Medicine outpatient clinic with the claim of being subjected to partner violence.Methods:The data of female cases sent between 01.01.2018 and 31.12.2020 were retrospectively scanned in terms of sociodemographic data, degree of physical violence and mental illnesses related to violence. It was evaluated using the SPSS package program.Results:The mean age of 143 female cases was 35.8±10.7, women with low educational and economic level and unemployed were exposed to more physical violence by their partners, 88.1% were exposed to physical violence, 54.5% were injured in the facial region. Bone fractures were detected in 16.4%, and severe mental illness developed in 45.9%. In addition, it was determined that the risk of suicide attempt was high in cases who were exposed to violence for many years and were diagnosed with a violence-related mental illness.Conclusion:It has been observed that low education and economic level, unemployment constitute a higher risk group for women to be subjected to physical violence by their partners. We believe that, together with the urgent legal regulations to prevent violence, the development of projects to increase the education level of women, create jobs and gain economic freedom will provide significant contributions and benefits to the prevention of violence.

Published
2023
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5. Targeting the Human βc Receptor Inhibits Contact Dermatitis in a Transgenic Mouse Model

Author

Yip, Kwok Ho, McKenzie, Duncan, Ramshaw, Hayley S., Chao, Jessica, McClure, Barbara J., Raquet, Elmar, Kraushaar, Timo, Röder, Joachim, Maxwell, Mhairi, Alhamdoosh, Monther, Hammet, Andrew, Fong, Jia Hong, Zeglinski, Kathleen, Monaghan, Katherine, Pant, Harshita, Grimbaldeston, Michele A., Vairo, Gino, Wilson, Nicholas J., Owczarek, Catherine M., Hercus, Timothy R., Lopez, Angel F., and Tumes, Damon J.

Published
2022
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8. Population-based estimates of breast cancer risk for carriers of pathogenic variants identified by gene-panel testing

Author

Southey, Melissa C., Dowty, James G., Riaz, Moeen, Steen, Jason A., Renault, Anne-Laure, Tucker, Katherine, Kirk, Judy, James, Paul, Winship, Ingrid, Pachter, Nicholas, Poplawski, Nicola, Grist, Scott, Park, Daniel J., Pope, Bernard J., Mahmood, Khalid, Hammet, Fleur, Mahmoodi, Maryam, Tsimiklis, Helen, Theys, Derrick, Rewse, Amanda, Willis, Amanda, Morrow, April, Speechly, Catherine, Harris, Rebecca, Sebra, Robert, Schadt, Eric, Lacaze, Paul, McNeil, John J., Giles, Graham G., Milne, Roger L., Hopper, John L., and Nguyen-Dumont, Tú

Published
2021
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10. Society for Cardiovascular Magnetic Resonance 2019 Case of the Week series

Author

Dahiya, Arun, Chao, Charles, Younger, John, Kar, Julia, Baldwin, Bryant M., Cohen, Michael V., Joseph, Shane, Chowdhry, Anam, Figarola, Maria S., Malozzi, Christopher, Nasser, M. Farhan, Nabeel, Yassar, Shah, Rajiv, Kennen, J. Michael, Aneja, Ashish, Khalil, Sameh, Ragab, Sara, Mohammed, Omnia, Moustafa, Taher, Hamdy, Ahmed, Ahmed, Shimaa, Heny, Ahmed, Taher, Maha, Ganigara, Madhusudan, Dhar, Arushi, Misra, Nilanjana, Alzubi, Jafar, Pannikottu, Kurian, Jabri, Ahmad, Hedge, Vinayak, Kanaa’n, Anmar, Lahorra, Joseph, de Waard, Dominique, Horne, David, Dhillon, Santokh, Sweeney, Aoife, Hamilton-Craig, Christian, Katikireddi, V. S., Wesley, Allan J., Hammet, Chris, Johnson, Jason N., and Chen, Sylvia S. M.

Published
2021
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13. Vgamma9Vdelta2 T cells recognize butyrophilin 2A1 and 3A1 heteromers

Author

Fulford, Thomas S, primary, Soliman, Caroline, additional, Castle, Rebecca G, additional, Rigau, Marc, additional, Ruan, Zheng, additional, Dolezal, Olan, additional, Seneviratna, Rebecca, additional, Brown, Hamish G, additional, Hanssen, Eric, additional, Hammet, Andrew, additional, Li, Shihan, additional, Redmond, Samuel J, additional, Chung, Amy, additional, Gorman, Michael A, additional, Parker, Michael W, additional, Patel, Onisha, additional, Peat, Thomas S, additional, Newman, Janet, additional, Behren, Andreas, additional, Gherardin, Nicholas A, additional, Godfrey, Dale I, additional, and Uldrich, Adam P, additional

Published
2023
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14. High-significance Sunyaev-Zel'dovich measurement: Abell 1914 seen with the Arcminute Microkelvin Imager

Author

AMI Collaboration, Barker, R., Biddulph, P., Bly, D., Boysen, R., Brown, A., Clementson, C., Crofts, M., Culverhouse, T., Czeres, J., Dace, R., D'Alessandro, R., Doherty, P., Duffett-Smith, P., Duggan, K., Ely, J., Felvus, M., Flynn, W., Geisbuesch, J., Grainge, K., Grainger, W., Hammet, D., Hills, R., Hobson, M., Holler, C., Jilley, R., Jones, M., Kaneko, T., Kneissl, R., Lancaster, K., Lasenby, A., Marshall, P., Newton, F., Norris, O., Northrop, I., Pooley, G., Quy, V., Saunders, R., Scaife, A., Schofield, J., Scott, P., Shaw, C., Taylor, A., Titterington, D., Velic, M., Waldram, E., West, S., Wood, B., Yassin, G., and Zwart, J.

Subjects
Astrophysics
Abstract

We report the first detection of a Sunyaev-Zel'dovich (S-Z) decrement with the Arcminute Microkelvin Imager (AMI). We have made commissioning observations towards the cluster A1914 and have measured an integrated flux density of -8.61 mJy in a uv-tapered map with noise level 0.19 mJy/beam. We find that the spectrum of the decrement, measured in the six channels between 13.5-18GHz, is consistent with that expected for a S-Z effect. The sensitivity of the telescope is consistent with the figures used in our simulations of cluster surveys with AMI., Comment: 5 pages, 6 figures, submitted to MNRAS Letters

Published
2005
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15. Genome-wide association studies identify four ER negative-specific breast cancer risk loci.

Author

Garcia-Closas, Montserrat, Couch, Fergus J, Lindstrom, Sara, Michailidou, Kyriaki, Schmidt, Marjanka K, Brook, Mark N, Orr, Nick, Rhie, Suhn Kyong, Riboli, Elio, Feigelson, Heather S, Le Marchand, Loic, Buring, Julie E, Eccles, Diana, Miron, Penelope, Fasching, Peter A, Brauch, Hiltrud, Chang-Claude, Jenny, Carpenter, Jane, Godwin, Andrew K, Nevanlinna, Heli, Giles, Graham G, Cox, Angela, Hopper, John L, Bolla, Manjeet K, Wang, Qin, Dennis, Joe, Dicks, Ed, Howat, Will J, Schoof, Nils, Bojesen, Stig E, Lambrechts, Diether, Broeks, Annegien, Andrulis, Irene L, Guénel, Pascal, Burwinkel, Barbara, Sawyer, Elinor J, Hollestelle, Antoinette, Fletcher, Olivia, Winqvist, Robert, Brenner, Hermann, Mannermaa, Arto, Hamann, Ute, Meindl, Alfons, Lindblom, Annika, Zheng, Wei, Devillee, Peter, Goldberg, Mark S, Lubinski, Jan, Kristensen, Vessela, Swerdlow, Anthony, Anton-Culver, Hoda, Dörk, Thilo, Muir, Kenneth, Matsuo, Keitaro, Wu, Anna H, Radice, Paolo, Teo, Soo Hwang, Shu, Xiao-Ou, Blot, William, Kang, Daehee, Hartman, Mikael, Sangrajrang, Suleeporn, Shen, Chen-Yang, Southey, Melissa C, Park, Daniel J, Hammet, Fleur, Stone, Jennifer, Veer, Laura J Van't, Rutgers, Emiel J, Lophatananon, Artitaya, Stewart-Brown, Sarah, Siriwanarangsan, Pornthep, Peto, Julian, Schrauder, Michael G, Ekici, Arif B, Beckmann, Matthias W, Dos Santos Silva, Isabel, Johnson, Nichola, Warren, Helen, Tomlinson, Ian, Kerin, Michael J, Miller, Nicola, Marme, Federick, Schneeweiss, Andreas, Sohn, Christof, Truong, Therese, Laurent-Puig, Pierre, Kerbrat, Pierre, Nordestgaard, Børge G, Nielsen, Sune F, Flyger, Henrik, Milne, Roger L, Perez, Jose Ignacio Arias, Menéndez, Primitiva, Müller, Heiko, Arndt, Volker, Stegmaier, Christa, Lichtner, Peter, Lochmann, Magdalena, and Justenhoven, Christina

Subjects
Gene ENvironmental Interaction and breast CAncer (GENICA) Network, kConFab Investigators, Familial Breast Cancer Study, Australian Breast Cancer Tissue Bank (ABCTB) Investigators, Humans, Breast Neoplasms, Genetic Predisposition to Disease, Receptors, Estrogen, Oligonucleotide Array Sequence Analysis, Risk Factors, Case-Control Studies, Cooperative Behavior, Genotype, Polymorphism, Single Nucleotide, Female, Meta-Analysis as Topic, Genome-Wide Association Study, Genetic Loci, Genetics, Human Genome, Estrogen, Breast Cancer, Cancer, Biological Sciences, Medical and Health Sciences, Developmental Biology
Abstract

Estrogen receptor (ER)-negative tumors represent 20-30% of all breast cancers, with a higher proportion occurring in younger women and women of African ancestry. The etiology and clinical behavior of ER-negative tumors are different from those of tumors expressing ER (ER positive), including differences in genetic predisposition. To identify susceptibility loci specific to ER-negative disease, we combined in a meta-analysis 3 genome-wide association studies of 4,193 ER-negative breast cancer cases and 35,194 controls with a series of 40 follow-up studies (6,514 cases and 41,455 controls), genotyped using a custom Illumina array, iCOGS, developed by the Collaborative Oncological Gene-environment Study (COGS). SNPs at four loci, 1q32.1 (MDM4, P = 2.1 × 10(-12) and LGR6, P = 1.4 × 10(-8)), 2p24.1 (P = 4.6 × 10(-8)) and 16q12.2 (FTO, P = 4.0 × 10(-8)), were associated with ER-negative but not ER-positive breast cancer (P > 0.05). These findings provide further evidence for distinct etiological pathways associated with invasive ER-positive and ER-negative breast cancers.

Published
2013

16. Breast cancer risk and 6q22.33: combined results from Breast Cancer Association Consortium and Consortium of Investigators on Modifiers of BRCA1/2.

Author

Kirchhoff, Tomas, Gaudet, Mia M, Antoniou, Antonis C, McGuffog, Lesley, Humphreys, Manjeet K, Dunning, Alison M, Bojesen, Stig E, Nordestgaard, Børge G, Flyger, Henrik, Kang, Daehee, Yoo, Keun-Young, Noh, Dong-Young, Ahn, Sei-Hyun, Dork, Thilo, Schürmann, Peter, Karstens, Johann H, Hillemanns, Peter, Couch, Fergus J, Olson, Janet, Vachon, Celine, Wang, Xianshu, Cox, Angela, Brock, Ian, Elliott, Graeme, Reed, Malcolm WR, Burwinkel, Barbara, Meindl, Alfons, Brauch, Hiltrud, Hamann, Ute, Ko, Yon-Dschun, GENICA Network, Broeks, Annegien, Schmidt, Marjanka K, Van 't Veer, Laura J, Braaf, Linde M, Johnson, Nichola, Fletcher, Olivia, Gibson, Lorna, Peto, Julian, Turnbull, Clare, Seal, Sheila, Renwick, Anthony, Rahman, Nazneen, Wu, Pei-Ei, Yu, Jyh-Cherng, Hsiung, Chia-Ni, Shen, Chen-Yang, Southey, Melissa C, Hopper, John L, Hammet, Fleur, Van Dorpe, Thijs, Dieudonne, Anne-Sophie, Hatse, Sigrid, Lambrechts, Diether, Andrulis, Irene L, Bogdanova, Natalia, Antonenkova, Natalia, Rogov, Juri I, Prokofieva, Daria, Bermisheva, Marina, Khusnutdinova, Elza, van Asperen, Christi J, Tollenaar, Robert AEM, Hooning, Maartje J, Devilee, Peter, Margolin, Sara, Lindblom, Annika, Milne, Roger L, Arias, José Ignacio, Zamora, M Pilar, Benítez, Javier, Severi, Gianluca, Baglietto, Laura, Giles, Graham G, kConFab, AOCS Study Group, Spurdle, Amanda B, Beesley, Jonathan, Chen, Xiaoqing, Holland, Helene, Healey, Sue, Wang-Gohrke, Shan, Chang-Claude, Jenny, Mannermaa, Arto, Kosma, Veli-Matti, Kauppinen, Jaana, Kataja, Vesa, Agnarsson, Bjarni A, Caligo, Maria A, Godwin, Andrew K, Nevanlinna, Heli, Heikkinen, Tuomas, Fredericksen, Zachary, Lindor, Noralane, Nathanson, Katherine L, Domchek, Susan M, SWE-BRCA, Loman, Niklas, Karlsson, Per, and Stenmark Askmalm, Marie

Subjects
GENICA Network, kConFab, AOCS Study Group, SWE-BRCA, HEBON, EMBRACE, BCAC/CIMBA, Chromosomes, Human, Pair 6, Humans, Breast Neoplasms, Genetic Predisposition to Disease, BRCA1 Protein, BRCA2 Protein, Receptors, Estrogen, Confidence Intervals, Proportional Hazards Models, Odds Ratio, Risk Factors, Heterozygote, Polymorphism, Single Nucleotide, Alleles, Middle Aged, Female, Genetic Association Studies, Chromosomes, Human, Pair 6, Polymorphism, Single Nucleotide, Receptors, Estrogen, General Science & Technology
Abstract

Recently, a locus on chromosome 6q22.33 (rs2180341) was reported to be associated with increased breast cancer risk in the Ashkenazi Jewish (AJ) population, and this association was also observed in populations of non-AJ European ancestry. In the present study, we performed a large replication analysis of rs2180341 using data from 31,428 invasive breast cancer cases and 34,700 controls collected from 25 studies in the Breast Cancer Association Consortium (BCAC). In addition, we evaluated whether rs2180341 modifies breast cancer risk in 3,361 BRCA1 and 2,020 BRCA2 carriers from 11 centers in the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Based on the BCAC data from women of European ancestry, we found evidence for a weak association with breast cancer risk for rs2180341 (per-allele odds ratio (OR) = 1.03, 95% CI 1.00-1.06, p = 0.023). There was evidence for heterogeneity in the ORs among studies (I(2) = 49.3%; p =

Published
2012

17. Is RNASEL:p.Glu265* a modifier of early-onset breast cancer risk for carriers of high-risk mutations?

Author

Tú Nguyen-Dumont, Zhi L. Teo, Fleur Hammet, Alexis Roberge, Maryam Mahmoodi, Helen Tsimiklis, Daniel J. Park, Bernard J. Pope, Andrew Lonie, Miroslav K. Kapuscinski, Khalid Mahmood, ABCFR, David E. Goldgar, Graham G. Giles, Ingrid Winship, John L. Hopper, and Melissa C. Southey

Subjects
RNASEL:P.Glu265*, Breast cancer, Modifier risk gene, Early-onset cancer, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Breast cancer risk for BRCA1 and BRCA2 pathogenic mutation carriers is modified by risk factors that cluster in families, including genetic modifiers of risk. We considered genetic modifiers of risk for carriers of high-risk mutations in other breast cancer susceptibility genes. Methods In a family known to carry the high-risk mutation PALB2:c.3113G>A (p.Trp1038*), whole-exome sequencing was performed on germline DNA from four affected women, three of whom were mutation carriers. Results RNASEL:p.Glu265* was identified in one of the PALB2 carriers who had two primary invasive breast cancer diagnoses before 50 years. Gene-panel testing of BRCA1, BRCA2, PALB2 and RNASEL in the Australian Breast Cancer Family Registry identified five carriers of RNASEL:p.Glu265* in 591 early onset breast cancer cases. Three of the five women (60%) carrying RNASEL:p.Glu265* also carried a pathogenic mutation in a breast cancer susceptibility gene compared with 30 carriers of pathogenic mutations in the 586 non-carriers of RNASEL:p.Glu265* (5%) (p

Published
2018
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19. Crystal Structure of Human BTN2A1 in Complex With Vgamma9-Vdelta2 T Cell Receptor

Author

Fulford, T.S., primary, Soliman, C., additional, Castle, R.G., additional, Rigau, M., additional, Ruan, Z., additional, Dolezal, O., additional, Seneviratna, R., additional, Brown, H.G., additional, Hanssen, E., additional, Hammet, A., additional, Li, S., additional, Redmond, S.J., additional, Chung, A., additional, Gorman, M.A., additional, Parker, M.W., additional, Patel, O., additional, Peat, T.S., additional, Newman, J., additional, Behren, A., additional, Gherardin, N.A., additional, Godfrey, D.I., additional, and Uldrich, A.P., additional

Published
2023
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22. 160. Maternal and Infant Outcomes Following Maternal Exposure to SARS-CoV-2 During Pregnancy in an Australian Cohort

Author

Hill, Rachel, primary, Gibbons, Andrew, additional, Han, Uni, additional, Suwakulsiri, Wittaya, additional, Taeska, Angela, additional, Hammet, Fleur, additional, Southey, Melissa, additional, Malhotra, Atul, additional, Fahey, Michael, additional, Palmer, Kirsten, additional, Hunt, Rod, additional, Lim, Izaak, additional, Newman-Morris, Vesna, additional, and Sundram, Suresh, additional

Published
2023
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23. Supplementary Table 3 from Rare Mutations in RINT1 Predispose Carriers to Breast and Lynch Syndrome–Spectrum Cancers

Author

Park, Daniel J., primary, Tao, Kayoko, primary, Le Calvez-Kelm, Florence, primary, Nguyen-Dumont, Tu, primary, Robinot, Nivonirina, primary, Hammet, Fleur, primary, Odefrey, Fabrice, primary, Tsimiklis, Helen, primary, Teo, Zhi L., primary, Thingholm, Louise B., primary, Young, Erin L., primary, Voegele, Catherine, primary, Lonie, Andrew, primary, Pope, Bernard J., primary, Roane, Terrell C., primary, Bell, Russell, primary, Hu, Hao, primary, Huff, Chad D., primary, Ellis, Jonathan, primary, Li, Jun, primary, Makunin, Igor V., primary, John, Esther M., primary, Andrulis, Irene L., primary, Terry, Mary B., primary, Daly, Mary, primary, Buys, Saundra S., primary, Snyder, Carrie, primary, Lynch, Henry T., primary, Devilee, Peter, primary, Giles, Graham G., primary, Hopper, John L., primary, Feng, Bing-Jian, primary, Lesueur, Fabienne, primary, Tavtigian, Sean V., primary, Southey, Melissa C., primary, and Goldgar, David E., primary

Published
2023
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24. Supplementary Figure 1 from Rare Mutations in RINT1 Predispose Carriers to Breast and Lynch Syndrome–Spectrum Cancers

Author

Park, Daniel J., primary, Tao, Kayoko, primary, Le Calvez-Kelm, Florence, primary, Nguyen-Dumont, Tu, primary, Robinot, Nivonirina, primary, Hammet, Fleur, primary, Odefrey, Fabrice, primary, Tsimiklis, Helen, primary, Teo, Zhi L., primary, Thingholm, Louise B., primary, Young, Erin L., primary, Voegele, Catherine, primary, Lonie, Andrew, primary, Pope, Bernard J., primary, Roane, Terrell C., primary, Bell, Russell, primary, Hu, Hao, primary, Huff, Chad D., primary, Ellis, Jonathan, primary, Li, Jun, primary, Makunin, Igor V., primary, John, Esther M., primary, Andrulis, Irene L., primary, Terry, Mary B., primary, Daly, Mary, primary, Buys, Saundra S., primary, Snyder, Carrie, primary, Lynch, Henry T., primary, Devilee, Peter, primary, Giles, Graham G., primary, Hopper, John L., primary, Feng, Bing-Jian, primary, Lesueur, Fabienne, primary, Tavtigian, Sean V., primary, Southey, Melissa C., primary, and Goldgar, David E., primary

Published
2023
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25. Supplementary Table 2 from Rare Mutations in RINT1 Predispose Carriers to Breast and Lynch Syndrome–Spectrum Cancers

Author

Park, Daniel J., primary, Tao, Kayoko, primary, Le Calvez-Kelm, Florence, primary, Nguyen-Dumont, Tu, primary, Robinot, Nivonirina, primary, Hammet, Fleur, primary, Odefrey, Fabrice, primary, Tsimiklis, Helen, primary, Teo, Zhi L., primary, Thingholm, Louise B., primary, Young, Erin L., primary, Voegele, Catherine, primary, Lonie, Andrew, primary, Pope, Bernard J., primary, Roane, Terrell C., primary, Bell, Russell, primary, Hu, Hao, primary, Huff, Chad D., primary, Ellis, Jonathan, primary, Li, Jun, primary, Makunin, Igor V., primary, John, Esther M., primary, Andrulis, Irene L., primary, Terry, Mary B., primary, Daly, Mary, primary, Buys, Saundra S., primary, Snyder, Carrie, primary, Lynch, Henry T., primary, Devilee, Peter, primary, Giles, Graham G., primary, Hopper, John L., primary, Feng, Bing-Jian, primary, Lesueur, Fabienne, primary, Tavtigian, Sean V., primary, Southey, Melissa C., primary, and Goldgar, David E., primary

Published
2023
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26. Supplementary Table 1 from Rare Mutations in RINT1 Predispose Carriers to Breast and Lynch Syndrome–Spectrum Cancers

Author

Park, Daniel J., primary, Tao, Kayoko, primary, Le Calvez-Kelm, Florence, primary, Nguyen-Dumont, Tu, primary, Robinot, Nivonirina, primary, Hammet, Fleur, primary, Odefrey, Fabrice, primary, Tsimiklis, Helen, primary, Teo, Zhi L., primary, Thingholm, Louise B., primary, Young, Erin L., primary, Voegele, Catherine, primary, Lonie, Andrew, primary, Pope, Bernard J., primary, Roane, Terrell C., primary, Bell, Russell, primary, Hu, Hao, primary, Huff, Chad D., primary, Ellis, Jonathan, primary, Li, Jun, primary, Makunin, Igor V., primary, John, Esther M., primary, Andrulis, Irene L., primary, Terry, Mary B., primary, Daly, Mary, primary, Buys, Saundra S., primary, Snyder, Carrie, primary, Lynch, Henry T., primary, Devilee, Peter, primary, Giles, Graham G., primary, Hopper, John L., primary, Feng, Bing-Jian, primary, Lesueur, Fabienne, primary, Tavtigian, Sean V., primary, Southey, Melissa C., primary, and Goldgar, David E., primary

Published
2023
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27. Data from Rare Mutations in RINT1 Predispose Carriers to Breast and Lynch Syndrome–Spectrum Cancers

Author

Park, Daniel J., primary, Tao, Kayoko, primary, Le Calvez-Kelm, Florence, primary, Nguyen-Dumont, Tu, primary, Robinot, Nivonirina, primary, Hammet, Fleur, primary, Odefrey, Fabrice, primary, Tsimiklis, Helen, primary, Teo, Zhi L., primary, Thingholm, Louise B., primary, Young, Erin L., primary, Voegele, Catherine, primary, Lonie, Andrew, primary, Pope, Bernard J., primary, Roane, Terrell C., primary, Bell, Russell, primary, Hu, Hao, primary, Huff, Chad D., primary, Ellis, Jonathan, primary, Li, Jun, primary, Makunin, Igor V., primary, John, Esther M., primary, Andrulis, Irene L., primary, Terry, Mary B., primary, Daly, Mary, primary, Buys, Saundra S., primary, Snyder, Carrie, primary, Lynch, Henry T., primary, Devilee, Peter, primary, Giles, Graham G., primary, Hopper, John L., primary, Feng, Bing-Jian, primary, Lesueur, Fabienne, primary, Tavtigian, Sean V., primary, Southey, Melissa C., primary, and Goldgar, David E., primary

Published
2023
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28. Supplementary Table 3 from Rare Mutations in RINT1 Predispose Carriers to Breast and Lynch Syndrome–Spectrum Cancers

Author

David E. Goldgar, Melissa C. Southey, Sean V. Tavtigian, Fabienne Lesueur, Bing-Jian Feng, John L. Hopper, Graham G. Giles, Peter Devilee, Henry T. Lynch, Carrie Snyder, Saundra S. Buys, Mary Daly, Mary B. Terry, Irene L. Andrulis, Esther M. John, Igor V. Makunin, Jun Li, Jonathan Ellis, Chad D. Huff, Hao Hu, Russell Bell, Terrell C. Roane, Bernard J. Pope, Andrew Lonie, Catherine Voegele, Erin L. Young, Louise B. Thingholm, Zhi L. Teo, Helen Tsimiklis, Fabrice Odefrey, Fleur Hammet, Nivonirina Robinot, Tu Nguyen-Dumont, Florence Le Calvez-Kelm, Kayoko Tao, and Daniel J. Park

Abstract

PDF file 65K, Primers used in assessment of RINT1 transcripts

Published
2023

29. Supplementary Figure 1 from Rare Mutations in RINT1 Predispose Carriers to Breast and Lynch Syndrome–Spectrum Cancers

Author

David E. Goldgar, Melissa C. Southey, Sean V. Tavtigian, Fabienne Lesueur, Bing-Jian Feng, John L. Hopper, Graham G. Giles, Peter Devilee, Henry T. Lynch, Carrie Snyder, Saundra S. Buys, Mary Daly, Mary B. Terry, Irene L. Andrulis, Esther M. John, Igor V. Makunin, Jun Li, Jonathan Ellis, Chad D. Huff, Hao Hu, Russell Bell, Terrell C. Roane, Bernard J. Pope, Andrew Lonie, Catherine Voegele, Erin L. Young, Louise B. Thingholm, Zhi L. Teo, Helen Tsimiklis, Fabrice Odefrey, Fleur Hammet, Nivonirina Robinot, Tu Nguyen-Dumont, Florence Le Calvez-Kelm, Kayoko Tao, and Daniel J. Park

Abstract

PDF file 199K, RINT1 c.1334-5delA, c.1334-1_1335delGTT minigene assay

Published
2023

30. Supplementary Table 1 from Rare Mutations in RINT1 Predispose Carriers to Breast and Lynch Syndrome–Spectrum Cancers

Author

David E. Goldgar, Melissa C. Southey, Sean V. Tavtigian, Fabienne Lesueur, Bing-Jian Feng, John L. Hopper, Graham G. Giles, Peter Devilee, Henry T. Lynch, Carrie Snyder, Saundra S. Buys, Mary Daly, Mary B. Terry, Irene L. Andrulis, Esther M. John, Igor V. Makunin, Jun Li, Jonathan Ellis, Chad D. Huff, Hao Hu, Russell Bell, Terrell C. Roane, Bernard J. Pope, Andrew Lonie, Catherine Voegele, Erin L. Young, Louise B. Thingholm, Zhi L. Teo, Helen Tsimiklis, Fabrice Odefrey, Fleur Hammet, Nivonirina Robinot, Tu Nguyen-Dumont, Florence Le Calvez-Kelm, Kayoko Tao, and Daniel J. Park

Abstract

PDF file 69K, Distribution of cases and controls included in the analysis, by study center and ethnic group

Published
2023

32. Maternal SARS-CoV-2 exposure alters infant DNA methylation

Author

Hill, Rachel A., primary, Gibbons, Andrew, additional, Han, Uni, additional, Suwakulsiri, Wittaya, additional, Taseska, Angela, additional, Hammet, Fleur, additional, Southey, Melissa, additional, Malhotra, Atul, additional, Fahey, Michael, additional, Palmer, Kirsten R., additional, Hunt, Rod W., additional, Lim, Izaak, additional, Newman-Morris, Vesna, additional, and Sundram, Suresh, additional

Published
2023
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36. Repeatability of methylation measures using a QIAseq targeted methyl panel and comparison with the Illumina HumanMethylation450 assay

Author

Fleur Hammet, Mahnaz Hosseinpour, Pierre Antoine Dugué, Ee Ming Wong, Melissa C. Southey, Tu Nguyen-Dumont, Graham G. Giles, James G. Dowty, Chenglong Yu, Jihoon E. Joo, John L. Hopper, and Robert J. MacInnis

Subjects
Oncology, medicine.medical_specialty, Science (General), Formalin-fixed paraffin-embedded, Intraclass correlation, QH301-705.5, Targeted bisulphite sequencing, Biology, Illumina Infinium methylation arrays, General Biochemistry, Genetics and Molecular Biology, chemistry.chemical_compound, Q1-390, Internal medicine, medicine, Bland–Altman plot, Biology (General), Intraclass correlation coefficient, Oligonucleotide Array Sequence Analysis, Paraffin Embedding, DNA methylation, High-Throughput Nucleotide Sequencing, General Medicine, Repeatability, Methylation, Genomics, Confidence interval, Whole blood, Research Note, chemistry, Medicine, High molecular weight dna, DNA
Abstract

Objective In previous studies using Illumina Infinium methylation arrays, we have identified DNA methylation marks associated with cancer predisposition and progression. In the present study, we have sought to find appropriate technology to both technically validate our data and expand our understanding of DNA methylation in these genomic regions. Here, we aimed to assess the repeatability of methylation measures made using QIAseq targeted methyl panel and to compare them with those obtained from the Illumina HumanMethylation450 (HM450K) assay. We included in the analysis high molecular weight DNA extracted from whole blood (WB) and DNA extracted from formalin-fixed paraffin-embedded tissues (FFPE). Results The repeatability of QIAseq-methylation measures was assessed at 40 CpGs, using the Intraclass Correlation Coefficient (ICC). The mean ICCs and 95% confidence intervals (CI) were 0.72 (0.62–0.81), 0.59 (0.47–0.71) and 0.80 (0.73–0.88) for WB, FFPE and both sample types combined, respectively. For technical replicates measured using QIAseq and HM450K, the mean ICCs (95% CI) were 0.53 (0.39–0.68), 0.43 (0.31–0.56) and 0.70 (0.59–0.80), respectively. Bland–Altman plots indicated good agreement between QIAseq and HM450K measurements. These results demonstrate that the QIAseq targeted methyl panel produces reliable and reproducible methylation measurements across the 40 CpGs that were examined.

Published
2021

39. 2018-2020 Yılları Arasında Partner Şiddeti Nedeniyle Mersin Tıp Fakültesi Hastanesine Başvuran Kadın Olguların Değerlendirilmesi.

Author

Işık, Hammet and Bilgin, Nursel Gamsız

Abstract

Copyright of Bulletin of Legal Medicine / Adli Tıp Bülteni is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023
Full Text
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40. Society for Cardiovascular Magnetic Resonance 2019 Case of the Week series

Author

Ahmed Heny, John F. Younger, Arushi Dhar, J. Michael Kennen, Vinayak Hedge, Omnia Mohammed, Anmar Kanaa'N, Bryant M. Baldwin, Shane Joseph, Maha Taher, Dominique de Waard, Santokh Dhillon, Madhusudan Ganigara, Yassar Nabeel, Jason N. Johnson, Jafar Alzubi, Christian Hamilton-Craig, Rajiv R. Shah, Ahmed Hamdy, Ahmad Jabri, Aoife Sweeney, Chris Hammet, Joseph A. Lahorra, Nilanjana Misra, Arun Dahiya, Sameh Khalil, Taher Moustafa, Sara Ragab, Ashish Aneja, Christopher Malozzi, Michael V. Cohen, Sylvia S. M. Chen, Maria S. Figarola, Charles Chao, Julia Kar, David Horne, Kurian Pannikottu, Shimaa Abdelrahman Ahmed, V. S. Katikireddi, Allan J. Wesley, Anam Chowdhry, and M. Farhan Nasser

Subjects
Cardiac tumor, medicine.medical_specialty, lcsh:Diseases of the circulatory (Cardiovascular) system, Cardiomyopathy, media_common.quotation_subject, Antineoplastic Agents, Review, Disease, Churg-Strauss Syndrome, 030204 cardiovascular system & hematology, Ventricular Function, Left, 030218 nuclear medicine & medical imaging, Diagnosis, Differential, Heart Neoplasms, Ventricular Dysfunction, Left, Young Adult, 03 medical and health sciences, Presentation, 0302 clinical medicine, Predictive Value of Tests, Humans, Medicine, Radiology, Nuclear Medicine and imaging, Medical physics, Cardiac Tumors, Web site, Angiology, media_common, Radiological and Ultrasound Technology, medicine.diagnostic_test, business.industry, Thrombosis, Magnetic resonance imaging, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Cardiotoxicity, lcsh:RC666-701, Female, Cardiology and Cardiovascular Medicine, business, MRI, Eosinophilic granulomatosis
Abstract

The Society for Cardiovascular Magnetic Resonance (SCMR) is an international society focused on the research, education, and clinical application of cardiovascular magnetic resonance (CMR). The SCMR web site (https://www.scmr.org) hosts a case series designed to present case reports demonstrating the unique attributes of CMR in the diagnosis or management of cardiovascular disease. Each clinical presentation is followed by a brief discussion of the disease and unique role of CMR in disease diagnosis or management guidance. By nature, some of these are somewhat esoteric, but all are instructive. In this publication, we provide a digital archive of the 2019 Case of the Week series as a means of further enhancing the education of those interested in CMR and as a means of more readily identifying these cases using a PubMed or similar search engine.

Published
2021

41. Samarkand: Cultural and Scientific Center of Central Asia

Author

ARSLAN, Hammet

Subjects
Religion, Semerkant,Orta Asya,İpek Yolu,Kültür,Sanat, Din Bilimi, Samarkand,Central Asia,Silk Road,Culture,Art
Abstract

Özbekistan’da yer alan Semerkant kenti, coğrafi olarak ülkenin güneydoğusunda konumlanır. Köklü bir tarihe sahip olan Semerkant, yerleşim yeri olma niteliğini daimi surette koruması açısından Orta Asya’nın en eski kentidir. Uzun tarihsel süreçte kent, birçok İmparatorluğun merkezi olmuş, birçok hakana, sultana, krala ve idareciye ev sahipliği yapmıştır. Burada hüküm süren devletlerin ve yöneticilerin kente eğitim, mimari, sanat ve kültür alanında yapmış olduğu katkıları halen görebilmek mümkündür. Ilıman ve yağışlı bir iklime sahip olması kentin daima cazibe merkezi olmasını sağlamıştır. Dolayısıyla insanların yerleşmeyi ve yaşamayı tercih ettikleri bir bölge olarak öne çıkmıştır. Doğu’yu Batı’ya bağlayan tarihi İpek Yolu üzerinde konumlanmış olması şehrin kültürel çeşitliliğine, ekonomik zenginliğine katkı sağlamıştır. Aslında bu yönleriyle kent bir “medeniyet beşiği” olarak anılabilir. Bütün bunlarla birlikte birbirinden farklı kültürel unsurlara yer vermesi kentin kültürel anlamda zenginleşmesine yol açmıştır. Bu bağlamda Semerkant’ın tarihine göz atıldığında Yahudilik, Mecusilik, Budizm, Hıristiyanlık, Maniheizm ve İslam gibi dinlerin tarihsel süreç içerinde kentte yaşama fırsatı bulduğu görülecektir. Özellikle İslam bilim ve düşünce tarihi açısından önemli simaların kentte yetişmesi kentin bir bilim merkezi haline gelmesine yol açmıştır. Başla İslam olmak üzere bütün bu dinler değişik yönleriyle kentin kültürel açıdan zenginleşmesine katkı sağlamışlardır. Bütün bu hususlar kentin önemli bir ticaret, kültür ve eğitim merkezi olarak adının duyulmasına vesile olmuştur. Biz bu makalemizde (i) Semerkant kentinin kültürel yapısının tarihsel açıdan teşekkül sürecini (ii) kentin kültürel yapısının temel unsurlarını (iii) kentte yaşayan etnik ve dini unsurların yaşama tecrübesini ve onların bariz yönlerini ortaya koymayı hedeflemekteyiz.

Published
2022

42. Population-based estimates of breast cancer risk for carriers of pathogenic variants identified by gene-panel testing.

Author

Southey M.C., Dowty J.G., Riaz M., Steen J.A., Renault A.-L., Tucker K., Kirk J., James P., Winship I., Pachter N., Poplawski N., Grist S., Park D.J., Pope B.J., Mahmood K., Hammet F., Mahmoodi M., Tsimiklis H., Theys D., Rewse A., Willis A., Morrow A., Speechly C., Harris R., Sebra R., Schadt E., Lacaze P., McNeil J.J., Giles G.G., Milne R.L., Hopper J.L., Nguyen-Dumont T., Southey M.C., Dowty J.G., Riaz M., Steen J.A., Renault A.-L., Tucker K., Kirk J., James P., Winship I., Pachter N., Poplawski N., Grist S., Park D.J., Pope B.J., Mahmood K., Hammet F., Mahmoodi M., Tsimiklis H., Theys D., Rewse A., Willis A., Morrow A., Speechly C., Harris R., Sebra R., Schadt E., Lacaze P., McNeil J.J., Giles G.G., Milne R.L., Hopper J.L., and Nguyen-Dumont T.

Abstract

Population-based estimates of breast cancer risk for carriers of pathogenic variants identified by gene-panel testing are urgently required. Most prior research has been based on women selected for high-risk features and more data is needed to make inference about breast cancer risk for women unselected for family history, an important consideration of population screening. We tested 1464 women diagnosed with breast cancer and 862 age-matched controls participating in the Australian Breast Cancer Family Study (ABCFS), and 6549 healthy, older Australian women enroled in the ASPirin in Reducing Events in the Elderly (ASPREE) study for rare germline variants using a 24-gene-panel. Odds ratios (ORs) were estimated using unconditional logistic regression adjusted for age and other potential confounders. We identified pathogenic variants in 11.1% of the ABCFS cases, 3.7% of the ABCFS controls and 2.2% of the ASPREE (control) participants. The estimated breast cancer OR [95% confidence interval] was 5.3 [2.1-16.2] for BRCA1, 4.0 [1.9-9.1] for BRCA2, 3.4 [1.4-8.4] for ATM and 4.3 [1.0-17.0] for PALB2. Our findings provide a population-based perspective to gene-panel testing for breast cancer predisposition and opportunities to improve predictors for identifying women who carry pathogenic variants in breast cancer predisposition genes.Copyright © 2021, The Author(s).

Published
2022

43. Incorporating Wifi into Watkins Regional Park

Author

Accomando, Delaney, Kweon, Byoung-Suk, Accomando, Delaney, Barton, Grace, Cavender, Nicole, Chow, Kianna, Cowley, Deanna, Duary, Rahat, Fan, Elin, Hammet, Bridgette, Hess, Jacob, Kirshenboim, Lital, Liriano, Alondra, Peterson, Luke, Rodrigo, Karisha, Shallbetter, Elise, Stebbins, Zaria, Steele, Alyssa, Xu, Yike, Ziolkowski, Theodore, Accomando, Delaney, Kweon, Byoung-Suk, Accomando, Delaney, Barton, Grace, Cavender, Nicole, Chow, Kianna, Cowley, Deanna, Duary, Rahat, Fan, Elin, Hammet, Bridgette, Hess, Jacob, Kirshenboim, Lital, Liriano, Alondra, Peterson, Luke, Rodrigo, Karisha, Shallbetter, Elise, Stebbins, Zaria, Steele, Alyssa, Xu, Yike, and Ziolkowski, Theodore

Abstract

The need for new approaches to ensure internet access that would bridge society's "digital divide" became evident when instruction shifted online during the COVID-19 pandemic. Project BRIDGE, a UMD project funded by the National Science Foundation, aims to bring free Wi-Fi to public parks while creating technology that could bridge the digital divide and provide internet access to individuals and communities who now struggle to get online. In this studio, students explored community needs by conducting a community engagement session in Watkins Regional Park and then proposing design solutions to accommodate Wi-Fi use in various areas of the park.

Published
2022

44. Budizm'de Kıssaların Önemi: Bazı Budist İnanış ve Uygulamaların Anlaşılmasına Dair Örnekler.

Author

ARSLAN, Hammet

Subjects
MUSTARD seeds, LUXURY, BUDDHISM, BUDDHISTS, RAFTS
Abstract

Copyright of Itobiad: Journal of the Human & Social Science Researches / İnsan ve Toplum Bilimleri Araştırmaları Dergisi is the property of Itobiad: Journal of the Human & Social Science Researches and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023
Full Text
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47. Mismatch repair gene pathogenic germline variants in a population-based cohort of breast cancer

Author

Derrick Theys, Melissa C. Southey, Maryam Mahmoodi, Fleur Hammet, Tu Nguyen-Dumont, Graham G. Giles, Daniel J. Park, Helen Tsimiklis, John L. Hopper, Bernard J. Pope, Mark Clendenning, Jason A. Steen, and Ingrid Winship

Subjects
Male, 0301 basic medicine, congenital, hereditary, and neonatal diseases and abnormalities, Cancer Research, Victoria, Population, Breast Neoplasms, 030105 genetics & heredity, Biology, DNA Mismatch Repair, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Genetics, medicine, PMS2, Humans, Genetic Predisposition to Disease, Registries, education, Germ-Line Mutation, Genetics (clinical), Mismatch Repair Endonuclease PMS2, education.field_of_study, Cancer prevention, Gene Expression Profiling, Cancer, medicine.disease, Colorectal Neoplasms, Hereditary Nonpolyposis, digestive system diseases, Lynch syndrome, Pedigree, DNA-Binding Proteins, MSH6, MutS Homolog 2 Protein, Oncology, MSH2, Case-Control Studies, 030220 oncology & carcinogenesis, Female, New South Wales, MutL Protein Homolog 1
Abstract

The advent of gene panel testing is challenging the previous practice of using clinically defined cancer family syndromes to inform single-gene genetic screening. Individual and family cancer histories that would have previously indicated testing of a single gene or a small number of related genes are now, increasingly, leading to screening across gene panels that contain larger numbers of genes. We have applied a gene panel test that included four DNA mismatch repair (MMR) genes (MLH1, MSH2, MSH6 and PMS2) to an Australian population-based case-control-family study of breast cancer. Altogether, eight pathogenic variants in MMR genes were identified: six in 1421 case-families (0.4%, 4 MSH6 and 2 PMS2) and two in 833 control-families (0.2%, one each of MLH1 and MSH2). This testing highlights the current and future challenges for clinical genetics in the context of anticipated gene panel-based population-based screening that includes the MMR genes. This testing is likely to provide additional opportunities for cancer prevention via cascade testing for Lynch syndrome and precision medicine for breast cancer treatment.

Published
2020

48. Targeting the human β𝒸 receptor inhibits contact dermatitis in a transgenic mouse model

Author

Gino Vairo, Nicholas J. Wilson, Hayley S. Ramshaw, Timo Kraushaar, Barbara J. McClure, Timothy R. Hercus, Mhairi Maxwell, Elmar Raquet, Damon J. Tumes, Duncan R. McKenzie, Kathleen Zeglinski, Harshita Pant, Michele A. Grimbaldeston, Catherine M. Owczarek, Joachim Röder, Angel F. Lopez, Jessica Chao, Kwok Ho Yip, Katherine Monaghan, Monther Alhamdoosh, Jia Hong Fong, Andrew Hammet, Yip, Kwok Ho, McKenzie, Duncan, Ramshaw, Hayley S, Chao, Jessica, McClure, Barbara J, Pant, Harshita, Grimbaldeston, Michele A, Hercus, Timothy R, Lopez, Angel F, and Tumes, Damon J

Subjects
Genetically modified mouse, biology, Transgene, Inflammation, Cell Biology, Dermatology, Granulocyte, Biochemistry, Cell biology, Haematopoiesis, medicine.anatomical_structure, biology.protein, medicine, Antibody, medicine.symptom, Receptor, Molecular Biology, STAT5
Abstract

Allergic contact dermatitis (ACD) is a prevalent and poorly controlled inflammatory disease caused by skin infiltration of T cells and granulocytes. The beta common (βc) cytokines GM-CSF, IL-3, and IL-5 are powerful regulators of granulocyte function that signal through their common receptor subunit βc, a property that has made βc an attractive target to simultaneously inhibit these cytokines. However, the species specificity of βc has precluded testing of inhibitors of human βc in mouse models. To overcome this problem, we developed a human βc receptor transgenic mouse strain with a hematopoietic cell‒specific expression of human βc instead of mouse βc. Human βc receptor transgenic cells responded to mouse GM-CSF and IL-5 but not to IL-3 in vitro and developed tissue pathology and cellular inflammation comparable with those in wild-type mice in a model of ACD. Similarly, Il3–/– mice developed ACD pathology comparable with that of wild-type mice. Importantly, the blocking anti–human βc antibody CSL311 strongly suppressed ear pinna thickening and histopathological changes typical of ACD and reduced accumulation of neutrophils, mast cells, and eosinophils in the skin. These results show that GM-CSF and IL-5 but not IL-3 are major mediators of ACD and define the human βc receptor transgenic mouse as a unique platform to test the inhibitors of βc in vivo. Refereed/Peer-reviewed

Published
2022

49. Maternal SARS-CoV-2 exposure alters infant DNA methylation

Author

Rachel A. Hill, Andrew Gibbons, Uni Han, Wittaya Suwakulsiri, Angela Taseska, Fleur Hammet, Melissa Southey, Atul Malhotra, Michael Fahey, Kirsten R. Palmer, Rod W. Hunt, Izaak Lim, Vesna Newman-Morris, and Suresh Sundram

Subjects
Nephrology
Abstract

Infection during pregnancy can increase the risk of neurodevelopmental disorders in offspring. The impact of maternal SARS-CoV-2 infection on infant neurodevelopment is poorly understood. The maternal immune response to infection may be mimicked in rodent models of maternal immune activation which recapitulate altered neurodevelopment and behavioural disturbances in the offspring. In these models, epigenetic mechanisms, in particular DNA methylation, are one pathway through which this risk is conferredDNA was extracted from buccal swab specimens from (n = 4) SARS-CoV-21962 hypermethylated CpG sites were identified with an unadjusted p-value of 0.05, where 1133 CpGs mapped to 959 unique protein coding genes, and 716 hypomethylated CpG sites mapped to 559 unique protein coding genes in SARS-CoV-2 exposed infants compared to non-exposed. One differentially methylated position (cg06758191), located in the gene body of AFAP1 that was hypomethylated in the SARS-CoV-2 exposed cohort was significant after correction for multiple testing (FDR-adjusted p-value0.00083). Two significant differentially methylated regions were identified; a hypomethylated intergenic region located in chromosome 6p proximal to the genes ZP57 and HLA-F (fwer0.004), and a hypomethylated region in the promoter and body of the gene GAREM2 (fwer0.036). Gene network enrichment analysis revealed differential methylation in genes corresponding to pathways relevant to neurodevelopment, including the ERBB pathway.These pilot data suggest that exposure to SARS-CoV-2

Published
2023

50. BUHARA: TÜRKİSTAN’DA ÇOK KÜLTÜRLÜ BİR KENT

Author

Hammet Arslan

Subjects
Automotive Engineering
Abstract

Günümüzde Özbekistan sınırları içerisinde bulunan Buhara kentinin uzun bir geçmişi vardır. Uzun tarihsel süreçte Türkler, Farslar, Yahudiler, Araplar, Ruslar başta olmak üzere kentte birçok etnik unsur ve birbirinden farklı kültür varlığını sürdürmüştür. Açık bir müze kabul edilen tarihi Buhara kenti, UNESCO kültürel miras listesinde yer almaktadır. Gerek tarihî bir ticaret yolunda konumlanmış olması gerekse de ürettiği ticari ürünler nedeniyle kente uğrayan tüccarlar hem maddi hem de kültürel anlamda kentin zenginleşmesine katkı sağlamışlardır. Dolayısıyla Buhara önemli bir ticaret, kültür ve eğitim merkezi olmuştur. Kent aynı zamanda farklı dini geleneklere mensup insanların buluşma noktası haline gelmiştir. Biz bu makalemizde (i) Buhara kentinin çok kültürlü yapısına zemin hazırlayan unsurları (ii) kentte hangi etnik ve dini unsurların bir arada yaşadığını ve onların öne çıkan yönlerini (iii) kentin çok kültürlülük tecrübesinin günümüz Türk dünyası açısından sunabileceği ekonomik, sosyal ve kültürel fırsatları ortaya koymayı hedeflemekteyiz.

Published
2018

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