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3 results on '"Hammed O. Faleke"'

2. Methanol fraction of Ficus mucoso (welw) prevents iron-induced oxidative damage and alters mitochondrial dysfunction in Drosophila melanogaster

Author

Hammed O. Faleke, Olufunso O. Olorunsogo, Olubukola T. Oyebode, and Amos O. Abolaji

Subjects
Pharmacology, Chemical Health and Safety, Antioxidant, biology, Health, Toxicology and Mutagenesis, medicine.medical_treatment, Public Health, Environmental and Occupational Health, General Medicine, Glutathione, Mitochondrion, Toxicology, Malondialdehyde, medicine.disease_cause, chemistry.chemical_compound, chemistry, Mitochondrial permeability transition pore, Catalase, Toxicity, medicine, biology.protein, Oxidative stress
Abstract

The present study investigated the antioxidant and cyto-/mito-protective roles of Methanol Fraction of Ficus mucoso (MFFM) in iron-induced oxidative damage in Drosophila melanogaster. At first, 10-day survival rates were carried out separately on FeSO4 and MFFM, respectively, after which ameliorative effects of MFFM were investigated on FeSO4-induced toxicity for 5 days using biochemical and behavioral markers. Additionally, mitochondria were isolated from treated D. melanogaster to assess mitochondrial Permeability Transition (mPT) pore opening. The results showed that FeSO4 significantly reduced survival rate, total thiol level and activities of catalase and glutathione-S-transferase in D. melanogaster. In addition, treatment with FeSO4 caused increased generation of H2O2, NO (nitrite/nitrates) and acetylcholinesterase (AChE) activity compared with control (p

Published
2021

3. Methanol fraction of

Author

Olubukola T, Oyebode, Amos O, Abolaji, Hammed O, Faleke, and Olufunso O, Olorunsogo

Subjects
Adenosine Triphosphatases, Lipid Peroxides, Mitochondrial Permeability Transition Pore, Methanol, Iron, Hydrogen Peroxide, Catalase, Ficus, Glutathione, Antioxidants, Mitochondria, Oxidative Stress, Drosophila melanogaster, Malondialdehyde, Acetylcholinesterase, Animals, Sulfhydryl Compounds, Nitrites, Glutathione Transferase
Abstract

The present study investigated the antioxidant and cyto-/mito-protective roles of Methanol Fraction of

Published
2021

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