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1,336 results on '"Hammami, S."'

2. Therapeutic Applications of Oxysterols and Derivatives in Age-Related Diseases, Infectious and Inflammatory Diseases, and Cancers

Author

Lizard, G, Ksila, M, Ghzaiel, I, Sassi, K, Zarrouk, A, Leoni, V, Poli, G, Rezig, L, Pires, V, Meziane, S, Atanasov, A, Hammami, S, Hammami, M, Masmoudi-Kouki, O, Hamdi, O, Jouanny, P, Samadi, M, Vejux, A, Ghrairi, T, Ksila M., Ghzaiel I., Sassi K., Zarrouk A., Leoni V., Poli G., Rezig L., Pires V., Meziane S., Atanasov A. G., Hammami S., Hammami M., Masmoudi-Kouki O., Hamdi O., Jouanny P., Samadi M., Vejux A., Ghrairi T., Lizard G., Lizard, G, Ksila, M, Ghzaiel, I, Sassi, K, Zarrouk, A, Leoni, V, Poli, G, Rezig, L, Pires, V, Meziane, S, Atanasov, A, Hammami, S, Hammami, M, Masmoudi-Kouki, O, Hamdi, O, Jouanny, P, Samadi, M, Vejux, A, Ghrairi, T, Ksila M., Ghzaiel I., Sassi K., Zarrouk A., Leoni V., Poli G., Rezig L., Pires V., Meziane S., Atanasov A. G., Hammami S., Hammami M., Masmoudi-Kouki O., Hamdi O., Jouanny P., Samadi M., Vejux A., Ghrairi T., and Lizard G.

Abstract

Oxysterols, resulting from the oxidation of cholesterol, are formed either by autoxidation, enzymatically, or by both processes. These molecules, which are provided in more or less important quantities depending on the type of diet, are also formed in the body and their presence is associated with a normal physiological activity. Their increase and decrease at the cellular level and in biological fluids can have significant consequences on health due or not to the interaction of some of these molecules with different types of receptors but also because oxysterols are involved in the regulation of RedOx balance, cytokinic and non-cytokinic inflammation, lipid metabolism, and induction of cell death. Currently, various pathologies such as age-related diseases, inflammatory and infectious diseases, and several cancers are associated with abnormal levels of oxysterols. Due to the important biological activities of oxysterols, their interaction with several receptors and their very likely implications in several diseases, this review focuses on these molecules and on oxysterol derivatives, which are often more efficient, in a therapeutic context. Currently, several oxysterol derivatives are developed and are attracting a lot of interest.

Published
2024

7. A proposal for fructosamines reference ranges

Author

Grouze, W., primary, Ben Khedher, M.B., additional, Oueslati, S., additional, Ghodbane, R., additional, Bouhajja, H., additional, Hammami, S., additional, Dabboubi, R., additional, Mahjoub, R., additional, Ben Messaoud, T., additional, Bibi, A., additional, and Talbi, E., additional

Published
2024
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13. Facteurs de rémission de la sarcoïdose pulmonaire

Author

Bchir, Y., primary, Mesfar, R., additional, Chaabene, I., additional, Daadaa, S., additional, Klai, R., additional, Hammami, S., additional, Abdellali, M., additional, Zrig, A., additional, Kochtali, I., additional, and Kechida, M., additional

Published
2023
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21. Lay People’s Ethical Attitudes To Placebo Treatment: A Q-Methodology Study

Author

Hammami MM, Hammami S, Aboushaar R, and Aljomah AS

Subjects
Lay people attitude, Placebo treatment, Virtue, Common good, Principlism, Q-methodology., Medicine (General), R5-920
Abstract

Muhammad M Hammami,1,2 Safa Hammami,3 Reem Aboushaar,4 Ahmed S Aljomah1 1Clinical Studies and Empirical Ethics Department, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia; 2Alfaisal University College of Medicine, Riyadh, Saudi Arabia; 3St. Mary Medical Center, San Francisco, CA, USA; 4MS IV, Florida Atlantic University, Boca Raton, FL, USACorrespondence: Muhammad M HammamiClinical Studies and Empirical Ethics Department, King Faisal Specialist Hospital and Research Centre, P O Box # 3354 (MBC 03), Riyadh 11211, Saudi ArabiaTel +966-1-442-4527Fax +966-1-442-7894Email Muhammad@kfshrc.edu.saBackground: Placebo-treatment acceptability is debated among ethicists, mostly due to conflict between respect-to-autonomy and beneficence principles. It is not clear how lay people balance these and other ethical principles.Methods: One hundred and eighty-seven respondents rank-ordered 42 opinion statements covering various ethical aspects of placebo-treatment, according to a 9-category symmetrical distribution. We analyzed statements’ scores using averaging-analysis and by-person factor analysis (Q-methodology).Results: Respondents’ mean (SD) age was 34.6 (10.6) years, 54% were women, 40% healthcare-related, 68% Muslims (31% Christians), and 39% received general education in Saudi Arabia (24% in the Philippines). On averaging-analysis, the most-agreeable statements were “Acceptable if benefit to patient large” and “Acceptable with physician intent to benefit patient”. The most-disagreeable statements were “Acceptable with physician self-benefit intent” and “Acceptable with large harm to other patients”. Muslims gave a higher rank to “Giving no description is acceptable”, “Acceptable with small benefit to patient”, and “Acceptable with physician intent to benefit patient” and a lower rank to “Acceptable to describe as inactive drug”, “Acceptable with physician intent to please patient caring relative”, and “Acceptable with moderate harm to other patients” (p

Published
2019

22. Relationship of the Component Composition of Supercritical CO2 Extracts of Wild Carrots with Growing Conditions.

Author

Aliev, A. M., Radzhabov, G. K., Vagabova, F. A., Islamova, F. I., Goriainov, S. V., Hajjar, F., and Hammami, S.

Abstract

To study the influence of ecological growing conditions on the chemical composition of plants, supercritical carbon dioxide extraction is carried out of wild carrot samples, widespread in all regions of the world with a temperate climate (Daucus carota subsp. maritimus). Using the methods of gas-liquid chromatography and mass spectral analysis, volatile organic compounds, fatty acids, and phytosterols in the studied objects are determined in the extracts obtained. The dependence of the chemical composition of wild carrots on its growing conditions (temperature, precipitation, solar radiation, etc.) is shown. [ABSTRACT FROM AUTHOR]

Published
2023
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23. A prospective multicentre surveillance study to investigate the risk associated with contaminated sinks in the intensive care unit

Author

Abdoush, H., Alfandari, S., Allaire, A., Aloe, L., Andreo, A., Antoine, E., Aurel, C., Azaouzi, A., Barry-Perdereau, V., Berrouane, Y., Blaise, S., Blanie, M., Bonjean, S., Borderan, G.C., Bounoua, M., Bourigault, C., Brean, V., Cecille, A., Chakaroun, H., Chanay, O., Chauvin, C., Curnier, V., Dalmas, H., Degallaix, D., Del Guidice, F., Delhomme, J., Demasure, M., Denis, C., Diaw, F., Dorel, S., Fourneret-Vivier, A., Fradin, B., Fribourg, A., Fumery, B., Gallais, S., Gazagne, L., Genillon, J.P., Gerbier, C., Glanard, A., Gouin, C., Gourmelen, F., Haond, C., Huart, C., Idri, N., Ionescu, P., Joron, S., Joseph, E., Labonne, V., Laurent, B., Le Coq, M., Lecuru, M., Legrand, A., Lehiani, O., Lepainteur, M., Lesteven, C., Llorens, M., Lugagne, N., Magneney, M., Mahamat, A., Marie, V., Mattioli, K., Mesnil, M., Mien, S., Morange, V., Negrin, N., Neulier, C., Ory, J., Ouzani, S., Perez, A., Pospisil, F., Sevin, T., Thomas-Hervieu, A., Valdes, A., Victoire, C., Vidal-Hollaender, B., Veyres, P., Zamfir, O., Anguel, N., Aussant, P., Badetti, C., Bavozet, F., Bayekula, J., Bedon-Carte, S., Bedos, J.P., Berthon, M., Bertrand, P.M., Brunel, E., Burel, C., Cerf, C., Chelha, R., Combaux, D., Da Silva, D., Damoisel, C., De Rudnicki, S., Debost, J., Desfrere, L., Della-Guardia, M., Dieye, E., Eisenmann, N., Ethuin, F., Favier, L., Fedun, S., Feller, M., Ferreira, L., Fillatre, P., Galin, X., Garot, D., Duclos, J. Gaubert, Gette, S., Georges, H., Godde, F., Hamet, M., Hira, M., Hoff, J., Hyvernat, H., Illinger, J., Jacques, L., Joubert, J., Kaidomar, M., Kalfon, P., Kallel, H., Lafforgue, P., Lambiotte, F., Landivier, A., Lazard, T., Le Gall, F., M'fam, W., Mariot, J., Martin, A., Martinet, O., Michaux, P., Michel, O., Mofredj, A., Montini, F., Muller, L., Pommier, C., Pottie, J.C., Prevost, F., Roger, C., Samat, C., Serpin, L., Siami, S., Alaoui, S. Sidki, Simaillaud, A., Simonoviez, P.Y., Slimani, H., Thouret, J.M., Toledano, D., Travert, B., Trouiller, P., Trouillet, G., Vescovali, C., Adochitei, A., Amara, M., Arsene, S., Bachelier, M.N., Barrans, A., Belmonte, O., Ben Hadj Yahia, S., Bensaid, T., Beretta-Salaun, G., Bertei, D., Bizet, J., Bleunven, S., Bonfils, F., Bonnet, R., Brisou, P., Cantet, P., Cattoen, C., Chaplain, C., Cordoleani, B., Dao, A., Dorangeon, E., Dupin, C., Farfour, E., Farrugia, C., Fines, M., Fougnot, S., Garnier, P., Guerin, M., Guillet-Caruba, C., Guinard, J., Goux, A., Hammami, S., Heusse, E., Heym, B., Alet, C. Hombrouck, Jacquemin, P., Jensen, C., Lacomme, M.P., Lafay, E., Lance, F., Lanselle, C., Lavigne, J.P., Le Gallou, F., Lechat, S., Lemenand, O., Leotard, S., Levast, M., Louis, G., Lourtet, J., Luizy, N., Mereghetti, L., Mignot, L., Moquet, O., Navarrot, J.C., Lory, M. Pancher, Parmeland, L., Patoz, P., Poussing, S., Ragot, C., Roudiere, L., Ruimy, R., Rose, V. Sainte, Sanchez, R., Seraphin, H., Vanson, M.l., Valentin, Anne-Sophie, Santos, Sandra Dos, Goube, Florent, Gimenes, Rémi, Decalonne, Marie, Mereghetti, Laurent, Daniau, Côme, and van der Mee-Marquet, Nathalie

Published
2021
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36. Typology of end-of-life priorities in Saudi females: averaging analysis and Q-methodology

Author

Hammami MM, Hammami S, Amer HA, and Khodr NA

Subjects
End-of-life priorities, End-of-life dis-priorities, Q-methodology, Score-averaging, Muslims, Saudi females, Medicine (General), R5-920
Abstract

Muhammad M Hammami,1,2 Safa Hammami,1 Hala A Amer,1 Nesrine A Khodr1 1Clinical Studies and Empirical Ethics Department, King Faisal Specialist Hospital and Research Centre, 2College of Medicine, Alfaisal University, Riyadh, Saudi Arabia Background: Understanding culture-and sex-related end-of-life preferences is essential to provide quality end-of-life care. We have previously explored end-of-life choices in Saudi males and found important culture-related differences and that Q-methodology is useful in identifying intraculture, opinion-based groups. Here, we explore Saudi females’ end-of-life choices.Methods: A volunteer sample of 68 females rank-ordered 47 opinion statements on end-of-life issues into a nine-category symmetrical distribution. The ranking scores of the statements were analyzed by averaging analysis and Q-methodology.Results: The mean age of the females in the sample was 30.3 years (range, 19–55 years). Among them, 51% reported average religiosity, 78% reported very good health, 79% reported very good life quality, and 100% reported high-school education or more. The extreme five overall priorities were to be able to say the statement of faith, be at peace with God, die without having the body exposed, maintain dignity, and resolve all conflicts. The extreme five overall dis-priorities were to die in the hospital, die well dressed, be informed about impending death by family/friends rather than doctor, die at peak of life, and not know if one has a fatal illness. Q-methodology identified five opinion-based groups with qualitatively different characteristics: “physical and emotional privacy concerned, family caring” (younger, lower religiosity), “whole person” (higher religiosity), “pain and informational privacy concerned” (lower life quality), “decisional privacy concerned” (older, higher life quality), and “life quantity concerned, family dependent” (high life quality, low life satisfaction). Out of the extreme 14 priorities/dis-priorities for each group, 21%–50% were not represented among the extreme 20 priorities/dis-priorities for the entire sample.Conclusion: Consistent with the previously reported findings in Saudi males, transcendence and dying in the hospital were the extreme end-of-life priority and dis-priority, respectively, in Saudi females. Body modesty was a major overall concern; however, concerns about pain, various types of privacy, and life quantity were variably emphasized by the five opinion-based groups but masked by averaging analysis. Keywords: end-of-life priorities, end-of-life dis-priorities, Q-methodology, score-averaging, Muslims, Saudi females

Published
2016

40. 7-Ketocholesterol: Effects on viral infections and hypothetical contribution in COVID-19

Author

Ghzaiel, I, Sassi, K, Zarrouk, A, Nury, T, Ksila, M, Leoni, V, Bouhaouala-Zahar, B, Hammami, S, Hammami, M, Mackrill, J, Samadi, M, Ghrairi, T, Vejux, A, Lizard, G, Ghzaiel I., Sassi K., Zarrouk A., Nury T., Ksila M., Leoni V., Bouhaouala-Zahar B., Hammami S., Hammami M., Mackrill J. J., Samadi M., Ghrairi T., Vejux A., Lizard G., Ghzaiel, I, Sassi, K, Zarrouk, A, Nury, T, Ksila, M, Leoni, V, Bouhaouala-Zahar, B, Hammami, S, Hammami, M, Mackrill, J, Samadi, M, Ghrairi, T, Vejux, A, Lizard, G, Ghzaiel I., Sassi K., Zarrouk A., Nury T., Ksila M., Leoni V., Bouhaouala-Zahar B., Hammami S., Hammami M., Mackrill J. J., Samadi M., Ghrairi T., Vejux A., and Lizard G.

Abstract

7-Ketocholesterol, which is one of the earliest cholesterol oxidization products identified, is essentially formed by the auto-oxidation of cholesterol. In the body, 7-ketocholesterol is both provided by food and produced endogenously. This pro-oxidant and pro-inflammatory molecule, which can activate apoptosis and autophagy at high concentrations, is an abundant component of oxidized Low Density Lipoproteins. 7-Ketocholesterol appears to significantly contribute to the development of age-related diseases (cardiovascular diseases, age-related macular degeneration, and Alzheimer's disease), chronic inflammatory bowel diseases and to certain cancers. Recent studies have also shown that 7-ketocholesterol has anti-viral activities, including on SARS-CoV-2, which are, however, lower than those of oxysterols resulting from the oxidation of cholesterol on the side chain. Furthermore, 7-ketocholesterol is increased in the serum of moderately and severely affected COVID-19 patients. In the case of COVID-19, it can be assumed that the antiviral activity of 7-ketocholesterol could be counterbalanced by its toxic effects, including pro-oxidant, pro-inflammatory and pro-coagulant activities that might promote the induction of cell death in alveolar cells. It is therefore suggested that this oxysterol might be involved in the pathophysiology of COVID-19 by contributing to the acute respiratory distress syndrome and promoting a deleterious, even fatal outcome. Thus, 7-ketocholesterol could possibly constitute a lipid biomarker of COVID-19 outcome and counteracting its toxic effects with adjuvant therapies might have beneficial effects in COVID-19 patients.

Published
2021

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