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2. Incidence of diabetes after SARS-CoV-2 infection in England and the implications of COVID-19 vaccination: a retrospective cohort study of 16 million people

Author

Al Arab, Marwa, Almaghrabi, Fatima, Andrews, Colm, Badrick, Ellena, Baz, Sarah, Beckford, Chelsea, Berman, Samantha, Bolton, Tom, Booth, Charlotte, Bowyer, Ruth, Boyd, Andy, Bridger-Staatz, Charis, Brophy, Sinead, Campbell, Archie, Campbell, Kirsteen C, Carnemolla, Alisia, Carpentieri, Jd, Cezard, Genevieve, Chaturvedi, Nishi, Cheetham, Nathan, Costello, Ruth, Cowling, Thomas, Crane, Matthew, Cuitun Coronado, Jose Ignacio, Curtis, Helen, Denaxas, Spiros, Denholm, Rachel, Di Gessa, Giorgio, Dobson, Richard, Douglas, Ian, Evans, Katharine M, Fang, Chao, Ferreira, Vanessa, Finnigan, Lucy, Fisher, Louis, Flaig, Robin, Folarin, Amos, Forbes, Harriet, Foster, Diane, Fox, Laura, Freydin, Maxim, Garcia, Paz, Gibson, Andy, Glen, Fiona, Goldacre, Ben, Goncalves Soares, Ana, Greaves, Felix, Green, Amelia, Green, Mark, Green, Michael, Griffith, Gareth, Hamill Howes, Lee, Hamilton, Olivia, Herbet, Annie, Herrett, Emily, Hopcroft, Lisa, Horne, Elsie, Hou, Bo, Hughes, Alun, Hulme, William, Huntley, Lizzie, Ip, Samantha, Jacques, Wels, Jezzard, Peter, Jones, Louise, Kanagaratnam, Arun, Karthikeyan Suseeladevi, Arun, Katikireddi, Vittal, Kellas, John, Kennedy, Jonathan I, Kibble, Milla, Knight, Rochelle, Knueppel, Anika, Kopasker, Daniel, Kromydas, Theocharis, Kwong, Alex, Langan, Sinead, Lemanska, Agnieszka, Lukaschuk, Elena, Mackenna, Brain, Macleod, John, Maddock, Jane, Mahalingasivam, Viyaasan, Mansfield, Kathryn, McArdle, Fintan, McCartney, Daniel, McEachan, Rosie, McElroy, Eoin, McLachlan, Stela, Mitchell, Ruth, Moltrecht, Bettina, Morley, Jess, Nab, Linda, Neubauer, Stefan, Nigrelli, Lidia, North, Teri, Northstone, Kate, Oakley, Jacqui, Palmer, Tom, Park, Chloe, Parker, Michael, Parsons, Sam, Patalay, Praveetha, Patel, Kishan, Perez-Reche, Francisco, Piechnik, Stefan, Piehlmaier, Dominik, Ploubidis, George, Rafeti, Elena, Raman, Betty, Ranjan, Yatharth, Rapala, Alicja, Rhead, Rebecca, Roberts, Amy, Sampri, Alexia, Sanders, Zeena-Britt, Santorelli, Gillian, Saunders, Laura C, Shah, Anoop, Shah, Syed Ahmar, Sharp, Steve, Shaw, Richard, Sheard, Laura, Sheikh, Aziz, Silverwood, Richard, Smeeth, Liam, Smith, Stephen, Stafford, Jean, Steptoe, Andrew, Sterne, Jonathan, Steves, Claire, Stewart, Callum, Taylor, Kurt, Tazare, John, Teece, Lucy, Thomas, Richard, Thompson, Ellen, Tilling, Kate, Timpson, Nicholas, Tomlinson, Laurie, Toms, Renin, Tunnicliffe, Elizabeth, Turner, Emma L, Walker, Alex, Walker, Venexia, Walter, Scott, Wang, Kevin, Wei, Yinghui, Whitehorn, Rebecca, Wielgoszewska, Bozena, Wild, James M, Willan, Kathryn, Willans, Robert, Williams, Dylan, Wong, Andrew, Wood, Angela, Woodward, Hannah, Wright, John, Yang, Tiffany, Zaninotto, Paola, Zheng, Bang, Zhu, Jingmin, Eastwood, Sophie, Horne, Elsie M F, Massey, Jon, Hopcroft, Lisa E M, Cuitun Coronado, Jose, Davy, Simon, Dillingham, Iain, Morton, Caroline, and Sterne, Jonathan A C

Published
2024
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3. Machine Learning and External Validation of the IDENTIFY Risk Calculator for Patients with Haematuria Referred to Secondary Care for Suspected Urinary Tract Cancer

Author

Orecchia, Luca, Tijerina, Adan, Simoes, Adrian, Ali, Ahmed, Nic an Riogh, Aisling, Wong, Albert, Kiciak, Alex, Ridgway, Alexander, Szostek, Alexandra, Dhanasekaran, Ananda, Cheong, Anderson, Atayi, Andrew, Ashpak, Ashna, Gutierrez Hidalgo, Beatriz, Teixeira, Bernardo, Maria Scornajenghi, Carlo, Marramaque, Carolina, Reynoldson, Charmian, Ho Chee Kong, Christopher, Crewe, Claire, Griffiths, Daniel, Amporore, Daniele, Mak, David, Sarkar, Debashis, Chung Wei Ling, Desmond, Bheenick, Divya, Hogan, Donnacha, Orakwe, Dubem, Gordon, Emma, Checcucci, Enrico, Nawaz, Faisal, Ribeiro Gonçalves, Fernando, Lozano Palacio, Fernando, Prata, Francesco, Claps, Francesco, Del Giudice, Francesco, Aggarwal, Gaurav, Marcq, Gautier, Hatzichristodoulou, Georgios, Karagiannidis, Georgios, Maria Pirola, Giacomo, Russo, Giorgio, Hytham, Hamid, Chun Khoo, Hau, Abozied, Hesham, Patel, Hiten D., Colvin, Holly, Ali, Iftikhar, Chibuzo, Ijeoma, Fakhradiyev, Ildar, Sokolakis, Ioannis, Tsikopoulos, Ioannis, Chong, James, Bondad, Jasper, Abbaraju, Jayasimha, Teoh, Jeremy, Whitburn, Jessica, Hayes, John, Luis Bauza Quetglas, Jose, Antonio Herranz Yague, Jose, Gomez Rivas, Juan, Colombo Stenstrom, Juan, de Mello, Kathryn Bandeira, Brodie, Katie, Tzelves, Lazaros, Lazaros, Lazarou, Paramore, Louise, Rico, Luis, Lilis, Lydia, Ullmann, Maha, Srour, Mahmoud, Boltri, Matteo, Mustafa, Mohamed, Eyad Takahji, Mohammad, Almusimie, Mohammed, Shakeel Inder, Mohammud, Elgamal, Mostafa, Misurati, Muftah, Ali, Muhammad-Kabir, Binnawara, Muhannud, Bhaloo, Nabeela, Vidal Crespo, Natalia, Ernesto Morales Palacios, Nelson, Santoni, Nicola, Pyrgidis, Nikolaos, Hamilton, Olivia, Abad Lopez, Pablo, Maheshkumar, Pattabiraman, Sountoulides, Petros, Piazza, Pietro, Moreno, Pilar, Sarmah, Piyush, Narayan, Prabhat, Banthia, Ravi, Matulewicz, Richard, Contieri, Roberto, David, Rotimi, Mohammad, Sabir, Abu, Sadiq, Alonso, Santiago, Ippoliti, Simona, Weber, Stephan, Abuhasanein, Suleiman, Lee, Taeweon, Klatte, Tobias, Trung Thanh, Tran, Wazir, Usman, Ulker, Volkan, Yeoh, W.S., Feuer, Zach, Elahi, Zain, Gall, Zara, Khadhouri, Sinan, Hramyka, Artsiom, Gallagher, Kevin, Light, Alexander, Edison, Marie, Alexander, Cameron, Kulkarni, Meghana, Zimmermann, Eleanor, Nathan, Arjun, Tran, Trung-Thanh, Kelsey, Tom, and Kasivisvanathan, Veeru

Published
2024
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4. Sporadic cerebral small vessel disease and cognitive abilities

Author

Hamilton, Olivia Kathryn Leigh, Wardlaw, Joanna, and Deary, Ian

Subjects
small vessel disease, cognitive abilities, cognitive ageing, Magnetic resonance imaging, dementia, stroke
Abstract

Cerebral small vessel disease (SVD) is a leading cause of vascular cognitive impairment, contributing to multiple neurological disorders ranging from stroke, to mild cognitive impairment and dementia. However, despite a huge number of studies on the subject, we have a limited understanding of how SVD affects cognitive ability. This thesis aims to address this knowledge gap, by examining domain-specific cognitive abilities in a range of clinical and non-clinical presentations of SVD. In the introductory chapters of this thesis I will discuss what is meant by the term cerebral small vessel disease (SVD), describing key radiological features of SVD and its varied clinical and non-clinical presentations. However, before considering the current consensus on how SVD impacts different domains of cognitive ability, I will first consider what happens to these abilities in the context healthy cognitive ageing. Finally, I will consider the current consensus on the pattern of cognitive changes that occur in SVD and will examine the vast and often conflicting evidence that underpins this. To gain a comprehensive overview of the published literature examining cognitive abilities in SVD, Chapter 4 presents a systematic review and meta-analysis of 69 studies presenting cognitive data for at least one cohort with SVD (n=3679) and one comparison control group without SVD (n=3229). Results indicated that relative to controls, cohorts with SVD performed more poorly on cognitive tests in all of the cognitive domains examined. Meta-regression analyses suggested that fewer years of education in the SVD vs. control groups accounted for a proportion of the differences in their test scores in some cognitive domains. Further meta-regression analyses suggested that cohorts with SVD-related cognitive impairment or dementia performed more poorly on tests in certain cognitive domains than cohorts with stroke or non-clinical presentations of SVD. Overall, however, SVD cohorts performed more poorly than controls on cognitive tests in all domains, regardless of their SVD presentation. Chapters 5 and 6 focus more closely on the key radiological markers of SVD and their associations with cognitive test scores using data from the Lothian Birth Cohort 1936 (LBC1936): a cohort of relatively healthy, community-dwelling, older individuals. To increase the fidelity with which SVD is typically measured, I combined computational volumes and visually-rated MRI markers of SVD to construct a variable representing the total MRI-visible burden of SVD. The study in Chapter 5 presents the results of cross-sectional associations between this latent SVD variable and latent variables of processing speed, verbal memory and visuospatial ability, within a structural equation modelling framework (SEM; n=540; mean age 72.6±0.7 years). Age, sex, vascular risk, depression status, and age-11 IQ were included as covariates. The latent SVD variable was negatively associated with all cognitive factors, in line with the results of the systematic review and meta-analysis. However, after accounting for the shared variance between the different cognitive domains (a construct described as general cognitive ability, which previous studies have not accounted for), only the association between the latent SVD variable and processing speed remained significant. This suggests that SVD's association with slowed processing speed is not driven by, but is independent of its association with poorer general cognitive ability. In Chapter 6 this work is developed further by exploring associations between the latent SVD variable and decline in the same latent cognitive factors over a period of 9 years, from the age of around 73 to 82, again in the LBC1936. This was carried out using latent growth curve modelling within a SEM framework. Age, sex, vascular risk, and age-11 IQ were included as covariates. Results indicated that the latent SVD variable was associated with greater decline in general cognitive ability and processing speed. However, after accounting for the covariance between tests of processing speed and general cognitive ability, only the association between greater SVD burden and decline in general cognitive ability remained significant. Whereas the results of Chapter 5 suggested that SVD burden at age 73 may have specific and independent effects on processing speed measured at the same age, the results of our longitudinal analyses suggest that SVD burden at age 73 associates with declining processing speed due to SVD's overarching association with general cognitive decline. In the final chapter of this thesis, I summarise the findings of these three studies, discuss their limitations, and make recommendations for future research.

Published
2021
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5. White Matter Hyperintensity Volume and Poststroke Cognition: An Individual Patient Data Pooled Analysis of 9 Ischemic Stroke Cohort Studies

Author

de Kort, Floor A.S., Coenen, Mirthe, Weaver, Nick A., Kuijf, Hugo J., Aben, Hugo P., Bae, Hee-Joon, Bordet, Régis, Cammà, Guido, Chen, Christopher P.L.H., Dewenter, Anna, Duering, Marco, Fang, Rong, van der Giessen, Ruben S., Hamilton, Olivia K.L., Hilal, Saima, Huenges Wajer, Irene M.C., Kan, Cheuk Ni, Kim, Jonguk, Kim, Beom Joon, Köhler, Sebastian, de Kort, Paul L.M., Koudstaal, Peter J., Lim, Jae-Sung, Lopes, Renaud, Mok, Vincent C.T., Staals, Julie, Venketasubramanian, Narayanaswamy, Verhagen, Charlotte M., Verhey, Frans R.J., Wardlaw, Joanna M., Xu, Xin, Yu, Kyung-Ho, Biesbroek, J. Matthijs, and Biessels, Geert Jan

Published
2023
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6. Ethnic differences in the indirect effects of the COVID-19 pandemic on clinical monitoring and hospitalisations for non-COVID conditions in England: a population-based, observational cohort study using the OpenSAFELY platform

Author

Chaturvedi, Nishi, Park, Chloe, Carnemolla, Alisia, Williams, Dylan, Knueppel, Anika, Boyd, Andy, Turner, Emma L., Evans, Katharine M., Thomas, Richard, Berman, Samantha, McLachlan, Stela, Crane, Matthew, Whitehorn, Rebecca, Oakley, Jacqui, Foster, Diane, Woodward, Hannah, Campbell, Kirsteen C., Timpson, Nicholas, Kwong, Alex, Soares, Ana Goncalves, Griffith, Gareth, Toms, Renin, Jones, Louise, Annie, Herbert, Mitchell, Ruth, Palmer, Tom, Sterne, Jonathan, Walker, Venexia, Huntley, Lizzie, Fox, Laura, Denholm, Rachel, Knight, Rochelle, Northstone, Kate, Kanagaratnam, Arun, Horne, Elsie, Forbes, Harriet, North, Teri, Taylor, Kurt, Arab, Marwa A.L., Walker, Scott, Coronado, Jose I.C., Karthikeyan, Arun S., Ploubidis, George, Moltrecht, Bettina, Booth, Charlotte, Parsons, Sam, Wielgoszewska, Bozena, Bridger-Staatz, Charis, Steves, Claire, Thompson, Ellen, Garcia, Paz, Cheetham, Nathan, Bowyer, Ruth, Freydin, Maxim, Roberts, Amy, Goldacre, Ben, Walker, Alex, Morley, Jess, Hulme, William, Nab, Linda, Fisher, Louis, MacKenna, Brian, Andrews, Colm, Curtis, Helen, Hopcroft, Lisa, Green, Amelia, Patalay, Praveetha, Maddock, Jane, Patel, Kishan, Stafford, Jean, Jacques, Wels, Tilling, Kate, Macleod, John, McElroy, Eoin, Shah, Anoop, Silverwood, Richard, Denaxas, Spiros, Flaig, Robin, McCartney, Daniel, Campbell, Archie, Tomlinson, Laurie, Tazare, John, Zheng, Bang, Smeeth, Liam, Herrett, Emily, Cowling, Thomas, Mansfield, Kate, Costello, Ruth E., Wang, Kevin, Mansfield, Kathryn, Mahalingasivam, Viyaasan, Douglas, Ian, Langan, Sinead, Brophy, Sinead, Parker, Michael, Kennedy, Jonathan, McEachan, Rosie, Wright, John, Willan, Kathryn, Badrick, Ellena, Santorelli, Gillian, Yang, Tiffany, Hou, Bo, Steptoe, Andrew, Giorgio, Di Gessa, Zhu, Jingmin, Zaninotto, Paola, Wood, Angela, Cezard, Genevieve, Ip, Samantha, Bolton, Tom, Sampri, Alexia, Rafeti, Elena, Almaghrabi, Fatima, Sheikh, Aziz, Shah, Syed A., Katikireddi, Vittal, Shaw, Richard, Hamilton, Olivia, Green, Michael, Kromydas, Theocharis, Kopasker, Daniel, Greaves, Felix, Willans, Robert, Glen, Fiona, Sharp, Steve, Hughes, Alun, Wong, Andrew, Howes, Lee Hamill, Rapala, Alicja, Nigrelli, Lidia, McArdle, Fintan, Beckford, Chelsea, Raman, Betty, Dobson, Richard, Folarin, Amos, Stewart, Callum, Ranjan, Yatharth, Carpentieri, Jd, Sheard, Laura, Fang, Chao, Baz, Sarah, Gibson, Andy, Kellas, John, Neubauer, Stefan, Piechnik, Stefan, Lukaschuk, Elena, Saunders, Laura C., Wild, James M., Smith, Stephen, Jezzard, Peter, Tunnicliffe, Elizabeth, Sanders, Zeena-Britt, Finnigan, Lucy, Ferreira, Vanessa, Green, Mark, Rhead, Rebecca, Kibble, Milla, Wei, Yinghui, Lemanska, Agnieszka, Perez-Reche, Francisco, Piehlmaier, Dominik, Teece, Lucy, Parker, Edward, Walker, Alex J., Inglesby, Peter, Curtis, Helen J., Morton, Caroline E., Morley, Jessica, Mehrkar, Amir, Bacon, Sebastian C.J., Hickman, George, Croker, Richard, Evans, David, Ward, Tom, DeVito, Nicholas J., Green, Amelia C.A., Massey, Jon, Smith, Rebecca M., Hulme, William J., Davy, Simon, Andrews, Colm D., Hopcroft, Lisa E.M., Drysdale, Henry, Dillingham, Iain, Park, Robin Y., Higgins, Rose, Cunningham, Christine, Wiedemann, Milan, Maude, Steven, Macdonald, Orla, Butler-Cole, Ben F.C., O'Dwyer, Thomas, Stables, Catherine L., Wood, Christopher, Brown, Andrew D., Speed, Victoria, Bridges, Lucy, Schaffer, Andrea L., Walters, Caroline E., Rentsch, Christopher T., Bhaskaran, Krishnan, Schultze, Anna, Williamson, Elizabeth J., McDonald, Helen I., Tomlinson, Laurie A., Mathur, Rohini, Eggo, Rosalind M., Wing, Kevin, Wong, Angel Y.S., Grieve, Richard, Grint, Daniel J., Mansfield, Kathryn E., Douglas, Ian J., Evans, Stephen J.W., Walker, Jemma L., Cowling, Thomas E., Herrett, Emily L., Parker, Edward P.K., Bates, Christopher, Cockburn, Jonathan, Parry, John, Hester, Frank, Harper, Sam, O'Hanlon, Shaun, Eavis, Alex, Jarvis, Richard, Avramov, Dima, Griffiths, Paul, Fowles, Aaron, Parkes, Nasreen, Nicholson, Brian, Perera, Rafael, Harrison, David, Khunti, Kamlesh, Sterne, Jonathan AC., Quint, Jennifer, Henderson, Alasdair D., Carreira, Helena, Bidulka, Patrick, Warren-Gash, Charlotte, Hayes, Joseph F., Quint, Jennifer K., Katikireddi, Srinivasa Vittal, and Langan, Sinéad M.

Published
2023
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7. The Meta VCI Map consortium for meta‐analyses on strategic lesion locations for vascular cognitive impairment using lesion‐symptom mapping: Design and multicenter pilot study

Author

Weaver, Nick A, Zhao, Lei, Biesbroek, J Matthijs, Kuijf, Hugo J, Aben, Hugo P, Bae, Hee‐Joon, Caballero, Miguel ÁA, Chappell, Francesca M, Chen, Christopher PLH, Dichgans, Martin, Duering, Marco, Georgakis, Marios K, van der Giessen, Ruben S, Gyanwali, Bibek, Hamilton, Olivia KL, Hilal, Saima, Hofe, Elise M vom, de Kort, Paul LM, Koudstaal, Peter J, Lam, Bonnie YK, Lim, Jae‐Sung, Makin, Stephen DJ, Mok, Vincent CT, Shi, Lin, Hernández, Maria C Valdés, Venketasubramanian, Narayanaswamy, Wardlaw, Joanna M, Wollenweber, Frank A, Wong, Adrian, Xin, Xu, consortium, Meta VCI Map, DeCarli, C, Fletcher, EA, Maillard, P, Barnes, J, Sudre, CH, Schott, JM, Ikram, MA, Papma, JM, Steketee, RME, Vernooij, MW, Bordet, R, Lopes, R, Huang, C‐W, Frayne, R, McCreary, CR, Smith, EE, group, Calgary Normative Study, Backes, W, Köhler, S, van Oostenbrugge, RJ, Staals, J, Verhey, F, Cheng, CY, Kalaria, RN, Werring, D, Hsu, JL, Huang, K‐L, van der Grond, J, Jukema, JW, van der Mast, RC, Nijboer, TCW, group, Framingham Heart Study, Yu, K‐H, group, The Dutch Parelsnoer Institute–Neurodegenerative diseases, Schmidt, R, Pirpamer, L, MacIntosh, BJ, Robertson, AD, de Leeuw, F‐E, Tuladhar, AM, Chaturvedi, N, Tillin, T, Brodaty, H, Sachdev, P, group, TABASCO, Barkhof, F, van der Flier, WM, Kappelle, LJ, and Biessels, Geert Jan

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Biomedical Imaging, Atherosclerosis, Clinical Research, Brain Disorders, Acquired Cognitive Impairment, Stroke, Neurosciences, Meta VCI Map consortium, Cerebrovascular disease, Consortium, Data harmonization, Lesion location, Lesion-symptom mapping, Small vessel disease, Support vector regression, Vascular cognitive impairment, Genetics, Biological psychology
Abstract

IntroductionThe Meta VCI Map consortium performs meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping. Integration of data from different cohorts will increase sample sizes, to improve brain lesion coverage and support comprehensive lesion-symptom mapping studies.MethodsCohorts with available imaging on white matter hyperintensities or infarcts and cognitive testing were invited. We performed a pilot study to test the feasibility of multicenter data processing and analysis and determine the benefits to lesion coverage.ResultsForty-seven groups have joined Meta VCI Map (stroke n = 7800 patients; memory clinic n = 4900; population-based n = 14,400). The pilot study (six ischemic stroke cohorts, n = 878) demonstrated feasibility of multicenter data integration (computed tomography/magnetic resonance imaging) and achieved marked improvement of lesion coverage.DiscussionMeta VCI Map will provide new insights into the relevance of vascular lesion location for cognitive dysfunction. After the successful pilot study, further projects are being prepared. Other investigators are welcome to join.

Published
2019

9. Cerebrovascular Reactivity in Patients With Small Vessel Disease: A Cross-Sectional Study

Author

Sleight, Emilie, Stringer, Michael S., Clancy, Una, Arteaga, Carmen, Jaime Garcia, Daniela, Hewins, Will, Jochems, Angela C.C., Hamilton, Olivia K.L., Manning, Cameron, Morgan, Alasdair G., Locherty, Rachel, Cheng, Yajun, Liu, Xiaodi, Zhang, Junfang, Hamilton, Iona, Jardine, Charlotte, Brown, Rosalind, Sakka, Eleni, Kampaite, Agniete, Wiseman, Stewart, Valdés-Hernández, Maria C., Chappell, Francesca M., Doubal, Fergus N., Marshall, Ian, Thrippleton, Michael J., and Wardlaw, Joanna M.

Published
2023
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10. Sex Differences in Poststroke Cognitive Impairment: A Multicenter Study in 2343 Patients With Acute Ischemic Stroke

Author

Exalto, Lieza G., Weaver, Nick A., Kuijf, Hugo J., Aben, Hugo P., Bae, Hee-Joon, Best, Jonathan G., Bordet, Régis, Chen, Christopher P.L.H., van der Giessen, Ruben S., Godefroy, Olivier, Gyanwali, Bibek, Hamilton, Olivia K.L., Hilal, Saima, Huenges Wajer, Irene M.C., Kim, Jonguk, Kappelle, L. Jaap, Kim, Beom Joon, Köhler, Sebastian, de Kort, Paul L.M., Koudstaal, Peter J., Lim, Jae-Sung, Makin, Stephen D.J., Mok, Vincent C.T., van Oostenbrugge, Robert J., Roussel, Martine, Staals, Julie, Valdés-Hernández, Maria del C., Venketasubramanian, Narayanaswamy, Verhey, Frans R.J., Wardlaw, Joanna M., Werring, David J., Xu, Xin, van Zandvoort, Martine J.E., Biesbroek, J. Matthijs, Chappell, Francesca M., and Biessels, Geert Jan

Published
2023
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11. Home working and social and mental wellbeing at different stages of the COVID-19 pandemic in the UK: Evidence from 7 longitudinal population surveys

Author

Wels, Jacques, Wielgoszewska, Bozena, Moltrecht, Bettina, Booth, Charlotte, Green, Michael J., Hamilton, Olivia KL, Demou, Evangelia, Di Gessa, Giorgio, Huggins, Charlotte, Zhu, Jingmin, Santorelli, Gillian, Silverwood, Richard J., Kopasker, Daniel, Shaw, Richard J., Hughes, Alun, Patalay, Praveetha, Steves, Claire, Chaturvedi, Nishi, Porteous, David J., Rhead, Rebecca, Katikireddi, Srinivasa Vittal, and Ploubidis, George B.

Subjects
Biological sciences
Abstract

Background Home working has increased since the Coronavirus Disease 2019 (COVID-19) pandemic's onset with concerns that it may have adverse health implications. We assessed the association between home working and social and mental wellbeing among the employed population aged 16 to 66 through harmonised analyses of 7 UK longitudinal studies. Methods and findings We estimated associations between home working and measures of psychological distress, low life satisfaction, poor self-rated health, low social contact, and loneliness across 3 different stages of the pandemic (T1 = April to June 2020 -first lockdown, T2 = July to October 2020 -eased restrictions, T3 = November 2020 to March 2021 -second lockdown) using modified Poisson regression and meta-analyses to pool results across studies. We successively adjusted the model for sociodemographic characteristics (e.g., age, sex), job characteristics (e.g., sector of activity, pre-pandemic home working propensities), and pre-pandemic health. Among respectively 10,367, 11,585, and 12,179 participants at T1, T2, and T3, we found higher rates of home working at T1 and T3 compared with T2, reflecting lockdown periods. Home working was not associated with psychological distress at T1 (RR = 0.92, 95% CI = 0.79 to 1.08) or T2 (RR = 0.99, 95% CI = 0.88 to 1.11), but a detrimental association was found with psychological distress at T3 (RR = 1.17, 95% CI = 1.05 to 1.30). Study limitations include the fact that pre-pandemic home working propensities were derived from external sources, no information was collected on home working dosage and possible reverse association between change in wellbeing and home working likelihood. Conclusions No clear evidence of an association between home working and mental wellbeing was found, apart from greater risk of psychological distress during the second lockdown, but differences across subgroups (e.g., by sex or level of education) may exist. Longer term shifts to home working might not have adverse impacts on population wellbeing in the absence of pandemic restrictions but further monitoring of health inequalities is required., Author(s): Jacques Wels 1,2,*, Bozena Wielgoszewska 3, Bettina Moltrecht 3, Charlotte Booth 3, Michael J. Green 4, Olivia KL Hamilton 4, Evangelia Demou 4, Giorgio Di Gessa 5, Charlotte Huggins [...]

Published
2023
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12. Strategic infarct locations for post-stroke cognitive impairment: a pooled analysis of individual patient data from 12 acute ischaemic stroke cohorts

Author

Weaver, Nick A, Kuijf, Hugo J, Aben, Hugo P, Abrigo, Jill, Bae, Hee-Joon, Barbay, Mélanie, Best, Jonathan G, Bordet, Régis, Chappell, Francesca M, Chen, Christopher P L H, Dondaine, Thibaut, van der Giessen, Ruben S, Godefroy, Olivier, Gyanwali, Bibek, Hamilton, Olivia K L, Hilal, Saima, Huenges Wajer, Irene M C, Kang, Yeonwook, Kappelle, L Jaap, Kim, Beom Joon, Köhler, Sebastian, de Kort, Paul L M, Koudstaal, Peter J, Kuchcinski, Gregory, Lam, Bonnie Y K, Lee, Byung-Chul, Lee, Keon-Joo, Lim, Jae-Sung, Lopes, Renaud, Makin, Stephen D J, Mendyk, Anne-Marie, Mok, Vincent C T, Oh, Mi Sun, van Oostenbrugge, Robert J, Roussel, Martine, Shi, Lin, Staals, Julie, del C Valdés-Hernández, Maria, Venketasubramanian, Narayanaswamy, Verhey, Frans R J, Wardlaw, Joanna M, Werring, David J, Xin, Xu, Yu, Kyung-Ho, van Zandvoort, Martine J E, Zhao, Lei, Biesbroek, J Matthijs, and Biessels, Geert Jan

Published
2021
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14. Impact of long-term white matter hyperintensity changes on mobility and dexterity

Author

Jochems, Angela C C, primary, Muñoz Maniega, Susana, additional, Chappell, Francesca M, additional, Clancy, Una, additional, Arteaga, Carmen, additional, Jaime Garcia, Daniela, additional, Hamilton, Olivia K L, additional, Hewins, Will, additional, Locherty, Rachel, additional, Backhouse, Ellen V, additional, Barclay, Gayle, additional, Jardine, Charlotte, additional, McIntyre, Donna, additional, Gerrish, Iona, additional, Cheng, Yajun, additional, Liu, Xiaodi, additional, Zhang, Junfang, additional, Kampaite, Agniete, additional, Sakka, Eleni, additional, Valdés Hernández, Maria, additional, Wiseman, Stewart, additional, Stringer, Michael S, additional, Thrippleton, Michael J, additional, Doubal, Fergus N, additional, and Wardlaw, Joanna M, additional

Published
2024
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16. Covid-19 Risk by work-related factors: Pooled analysis of individual linked data from 14 cohorts

Author

Gittins, Matthew, primary, Rhodes, Sarah, additional, Wels, Jacques, additional, Wielgoszewska, Bożena, additional, Zhu, Jingmin, additional, Shaw, Richard J, additional, Hamilton, Olivia KL, additional, Demou, Evangelia, additional, Stevenson, Anna J, additional, Rhead, Rebecca, additional, Katikireddi, Srinivasa Vittal, additional, Ploubidis, George B, additional, and van Tongeren, Martie, additional

Published
2023
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18. The Meta VCI Map consortium for meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping: Design and multicenter pilot study

Author

DeCarli, C., Fletcher, E.A., Maillard, P., Barnes, J., Sudre, C.H., Schott, J.M., Ikram, M.A., Papma, J.M., Steketee, R.M.E., Vernooij, M.W., Bordet, R., Lopes, R., Huang, C.-W., Frayne, R., McCreary, C.R., Smith, E.E., Backes, W., Köhler, S., van Oostenbrugge, R.J., Staals, J., Verhey, F., Cheng, C.Y., Kalaria, R.N., Werring, D., Hsu, J.L., Huang, K.-L., van der Grond, J., Jukema, J.W., van der Mast, R.C., Nijboer, T.C.W., Yu, K.-H., Schmidt, R., Pirpamer, L., MacIntosh, B.J., Robertson, A.D., de Leeuw, F.-E., Tuladhar, A.M., Chaturvedi, N., Tillin, T., Brodaty, H., Sachdev, P., Barkhof, F., van der Flier, W.M., Kappelle, L.J., Weaver, Nick A., Zhao, Lei, Biesbroek, J. Matthijs, Kuijf, Hugo J., Aben, Hugo P., Bae, Hee-Joon, Caballero, Miguel Á.A., Chappell, Francesca M., Chen, Christopher P.L.H., Dichgans, Martin, Duering, Marco, Georgakis, Marios K., van der Giessen, Ruben S., Gyanwali, Bibek, Hamilton, Olivia K.L., Hilal, Saima, vom Hofe, Elise M., de Kort, Paul L.M., Koudstaal, Peter J., Lam, Bonnie Y.K., Lim, Jae-Sung, Makin, Stephen D.J., Mok, Vincent C.T., Shi, Lin, Valdés Hernández, Maria C., Venketasubramanian, Narayanaswamy, Wardlaw, Joanna M., Wollenweber, Frank A., Wong, Adrian, Xin, Xu, and Biessels, Geert Jan

Published
2019
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19. Incidence of diabetes after SARS-CoV-2 infection in England and the implications of COVID-19 vaccination: a retrospective cohort study of 16 million people

Author

Taylor, Kurt, Eastwood, Sophie, Walker, Venexia, Cezard, Genevieve, Knight, Rochelle, Al Arab, Marwa, Wei, Yinghui, Horne, Elsie M F, Teece, Lucy, Forbes, Harriet, Walker, Alex, Fisher, Louis, Massey, Jon, Hopcroft, Lisa E M, Palmer, Tom, Cuitun Coronado, Jose, Ip, Samantha, Davy, Simon, Dillingham, Iain, Morton, Caroline, Greaves, Felix, Macleod, John, Goldacre, Ben, Wood, Angela, Chaturvedi, Nishi, Sterne, Jonathan A C, Denholm, Rachel, Al Arab, Marwa, Almaghrabi, Fatima, Andrews, Colm, Badrick, Ellena, Baz, Sarah, Beckford, Chelsea, Berman, Samantha, Bolton, Tom, Booth, Charlotte, Bowyer, Ruth, Boyd, Andy, Bridger-Staatz, Charis, Brophy, Sinead, Campbell, Archie, Campbell, Kirsteen C, Carnemolla, Alisia, Carpentieri, Jd, Cezard, Genevieve, Chaturvedi, Nishi, Cheetham, Nathan, Costello, Ruth, Cowling, Thomas, Crane, Matthew, Cuitun Coronado, Jose Ignacio, Curtis, Helen, Denaxas, Spiros, Denholm, Rachel, Di Gessa, Giorgio, Dobson, Richard, Douglas, Ian, Evans, Katharine M, Fang, Chao, Ferreira, Vanessa, Finnigan, Lucy, Fisher, Louis, Flaig, Robin, Folarin, Amos, Forbes, Harriet, Foster, Diane, Fox, Laura, Freydin, Maxim, Garcia, Paz, Gibson, Andy, Glen, Fiona, Goldacre, Ben, Goncalves Soares, Ana, Greaves, Felix, Green, Amelia, Green, Mark, Green, Michael, Griffith, Gareth, Hamill Howes, Lee, Hamilton, Olivia, Herbet, Annie, Herrett, Emily, Hopcroft, Lisa, Horne, Elsie, Hou, Bo, Hughes, Alun, Hulme, William, Huntley, Lizzie, Ip, Samantha, Jacques, Wels, Jezzard, Peter, Jones, Louise, Kanagaratnam, Arun, Karthikeyan Suseeladevi, Arun, Katikireddi, Vittal, Kellas, John, Kennedy, Jonathan I, Kibble, Milla, Knight, Rochelle, Knueppel, Anika, Kopasker, Daniel, Kromydas, Theocharis, Kwong, Alex, Langan, Sinead, Lemanska, Agnieszka, Lukaschuk, Elena, Mackenna, Brain, Macleod, John, Maddock, Jane, Mahalingasivam, Viyaasan, Mansfield, Kathryn, McArdle, Fintan, McCartney, Daniel, McEachan, Rosie, McElroy, Eoin, McLachlan, Stela, Mitchell, Ruth, Moltrecht, Bettina, Morley, Jess, Nab, Linda, Neubauer, Stefan, Nigrelli, Lidia, North, Teri, Northstone, Kate, Oakley, Jacqui, Palmer, Tom, Park, Chloe, Parker, Michael, Parsons, Sam, Patalay, Praveetha, Patel, Kishan, Perez-Reche, Francisco, Piechnik, Stefan, Piehlmaier, Dominik, Ploubidis, George, Rafeti, Elena, Raman, Betty, Ranjan, Yatharth, Rapala, Alicja, Rhead, Rebecca, Roberts, Amy, Sampri, Alexia, Sanders, Zeena-Britt, Santorelli, Gillian, Saunders, Laura C, Shah, Anoop, Shah, Syed Ahmar, Sharp, Steve, Shaw, Richard, Sheard, Laura, Sheikh, Aziz, Silverwood, Richard, Smeeth, Liam, Smith, Stephen, Stafford, Jean, Steptoe, Andrew, Sterne, Jonathan, Steves, Claire, Stewart, Callum, Taylor, Kurt, Tazare, John, Teece, Lucy, Thomas, Richard, Thompson, Ellen, Tilling, Kate, Timpson, Nicholas, Tomlinson, Laurie, Toms, Renin, Tunnicliffe, Elizabeth, Turner, Emma L, Walker, Alex, Walker, Venexia, Walter, Scott, Wang, Kevin, Wei, Yinghui, Whitehorn, Rebecca, Wielgoszewska, Bozena, Wild, James M, Willan, Kathryn, Willans, Robert, Williams, Dylan, Wong, Andrew, Wood, Angela, Woodward, Hannah, Wright, John, Yang, Tiffany, Zaninotto, Paola, Zheng, Bang, and Zhu, Jingmin

Abstract

Some studies have shown that the incidence of type 2 diabetes increases after a diagnosis of COVID-19, although the evidence is not conclusive. However, the effects of the COVID-19 vaccine on this association, or the effect on other diabetes subtypes, are not clear. We aimed to investigate the association between COVID-19 and incidence of type 2, type 1, gestational and non-specific diabetes, and the effect of COVID- 19 vaccination, up to 52 weeks after diagnosis.

Published
2024
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21. Associations between SARS-CoV-2 infection and subsequent economic inactivity and employment status: pooled analyses of five linked longitudinal surveys

Author

Shaw, Richard J, primary, Rhead, Rebecca, additional, Silverwood, Richard J, additional, Wels, Jacques, additional, Zhu, Jingmin, additional, Hamilton, Olivia KL, additional, Gessa, Giorgio Di, additional, Bowyer, Ruth CE, additional, Moltrecht, Bettina, additional, Green, Michael J, additional, Demou, Evangelia, additional, Pattaro, Serena, additional, Zaninotto, Paola, additional, Boyd, Andy, additional, Greaves, Felix, additional, Chaturvedi, Nish, additional, Ploubidis, George B., additional, and Katikireddi, Srinivasa Vittal, additional

Published
2023
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23. Ethnic differences in the indirect effects of the COVID-19 pandemic on clinical monitoring and hospitalisations for non-COVID conditions in England: a population-based, observational cohort study using the OpenSAFELY platform

Author

Costello, Ruth E., primary, Tazare, John, additional, Piehlmaier, Dominik, additional, Herrett, Emily, additional, Parker, Edward P.K., additional, Zheng, Bang, additional, Mansfield, Kathryn E., additional, Henderson, Alasdair D., additional, Carreira, Helena, additional, Bidulka, Patrick, additional, Wong, Angel Y.S., additional, Warren-Gash, Charlotte, additional, Hayes, Joseph F., additional, Quint, Jennifer K., additional, MacKenna, Brian, additional, Mehrkar, Amir, additional, Eggo, Rosalind M., additional, Katikireddi, Srinivasa Vittal, additional, Tomlinson, Laurie, additional, Langan, Sinéad M., additional, Mathur, Rohini, additional, Chaturvedi, Nishi, additional, Park, Chloe, additional, Carnemolla, Alisia, additional, Williams, Dylan, additional, Knueppel, Anika, additional, Boyd, Andy, additional, Turner, Emma L., additional, Evans, Katharine M., additional, Thomas, Richard, additional, Berman, Samantha, additional, McLachlan, Stela, additional, Crane, Matthew, additional, Whitehorn, Rebecca, additional, Oakley, Jacqui, additional, Foster, Diane, additional, Woodward, Hannah, additional, Campbell, Kirsteen C., additional, Timpson, Nicholas, additional, Kwong, Alex, additional, Soares, Ana Goncalves, additional, Griffith, Gareth, additional, Toms, Renin, additional, Jones, Louise, additional, Annie, Herbert, additional, Mitchell, Ruth, additional, Palmer, Tom, additional, Sterne, Jonathan, additional, Walker, Venexia, additional, Huntley, Lizzie, additional, Fox, Laura, additional, Denholm, Rachel, additional, Knight, Rochelle, additional, Northstone, Kate, additional, Kanagaratnam, Arun, additional, Horne, Elsie, additional, Forbes, Harriet, additional, North, Teri, additional, Taylor, Kurt, additional, Arab, Marwa A.L., additional, Walker, Scott, additional, Coronado, Jose I.C., additional, Karthikeyan, Arun S., additional, Ploubidis, George, additional, Moltrecht, Bettina, additional, Booth, Charlotte, additional, Parsons, Sam, additional, Wielgoszewska, Bozena, additional, Bridger-Staatz, Charis, additional, Steves, Claire, additional, Thompson, Ellen, additional, Garcia, Paz, additional, Cheetham, Nathan, additional, Bowyer, Ruth, additional, Freydin, Maxim, additional, Roberts, Amy, additional, Goldacre, Ben, additional, Walker, Alex, additional, Morley, Jess, additional, Hulme, William, additional, Nab, Linda, additional, Fisher, Louis, additional, Andrews, Colm, additional, Curtis, Helen, additional, Hopcroft, Lisa, additional, Green, Amelia, additional, Patalay, Praveetha, additional, Maddock, Jane, additional, Patel, Kishan, additional, Stafford, Jean, additional, Jacques, Wels, additional, Tilling, Kate, additional, Macleod, John, additional, McElroy, Eoin, additional, Shah, Anoop, additional, Silverwood, Richard, additional, Denaxas, Spiros, additional, Flaig, Robin, additional, McCartney, Daniel, additional, Campbell, Archie, additional, Smeeth, Liam, additional, Cowling, Thomas, additional, Mansfield, Kate, additional, Costello, Ruth E., additional, Wang, Kevin, additional, Mansfield, Kathryn, additional, Mahalingasivam, Viyaasan, additional, Douglas, Ian, additional, Langan, Sinead, additional, Brophy, Sinead, additional, Parker, Michael, additional, Kennedy, Jonathan, additional, McEachan, Rosie, additional, Wright, John, additional, Willan, Kathryn, additional, Badrick, Ellena, additional, Santorelli, Gillian, additional, Yang, Tiffany, additional, Hou, Bo, additional, Steptoe, Andrew, additional, Giorgio, Di Gessa, additional, Zhu, Jingmin, additional, Zaninotto, Paola, additional, Wood, Angela, additional, Cezard, Genevieve, additional, Ip, Samantha, additional, Bolton, Tom, additional, Sampri, Alexia, additional, Rafeti, Elena, additional, Almaghrabi, Fatima, additional, Sheikh, Aziz, additional, Shah, Syed A., additional, Katikireddi, Vittal, additional, Shaw, Richard, additional, Hamilton, Olivia, additional, Green, Michael, additional, Kromydas, Theocharis, additional, Kopasker, Daniel, additional, Greaves, Felix, additional, Willans, Robert, additional, Glen, Fiona, additional, Sharp, Steve, additional, Hughes, Alun, additional, Wong, Andrew, additional, Howes, Lee Hamill, additional, Rapala, Alicja, additional, Nigrelli, Lidia, additional, McArdle, Fintan, additional, Beckford, Chelsea, additional, Raman, Betty, additional, Dobson, Richard, additional, Folarin, Amos, additional, Stewart, Callum, additional, Ranjan, Yatharth, additional, Carpentieri, Jd, additional, Sheard, Laura, additional, Fang, Chao, additional, Baz, Sarah, additional, Gibson, Andy, additional, Kellas, John, additional, Neubauer, Stefan, additional, Piechnik, Stefan, additional, Lukaschuk, Elena, additional, Saunders, Laura C., additional, Wild, James M., additional, Smith, Stephen, additional, Jezzard, Peter, additional, Tunnicliffe, Elizabeth, additional, Sanders, Zeena-Britt, additional, Finnigan, Lucy, additional, Ferreira, Vanessa, additional, Green, Mark, additional, Rhead, Rebecca, additional, Kibble, Milla, additional, Wei, Yinghui, additional, Lemanska, Agnieszka, additional, Perez-Reche, Francisco, additional, Teece, Lucy, additional, Parker, Edward, additional, Walker, Alex J., additional, Inglesby, Peter, additional, Curtis, Helen J., additional, Morton, Caroline E., additional, Morley, Jessica, additional, Bacon, Sebastian C.J., additional, Hickman, George, additional, Croker, Richard, additional, Evans, David, additional, Ward, Tom, additional, DeVito, Nicholas J., additional, Green, Amelia C.A., additional, Massey, Jon, additional, Smith, Rebecca M., additional, Hulme, William J., additional, Davy, Simon, additional, Andrews, Colm D., additional, Hopcroft, Lisa E.M., additional, Drysdale, Henry, additional, Dillingham, Iain, additional, Park, Robin Y., additional, Higgins, Rose, additional, Cunningham, Christine, additional, Wiedemann, Milan, additional, Maude, Steven, additional, Macdonald, Orla, additional, Butler-Cole, Ben F.C., additional, O'Dwyer, Thomas, additional, Stables, Catherine L., additional, Wood, Christopher, additional, Brown, Andrew D., additional, Speed, Victoria, additional, Bridges, Lucy, additional, Schaffer, Andrea L., additional, Walters, Caroline E., additional, Rentsch, Christopher T., additional, Bhaskaran, Krishnan, additional, Schultze, Anna, additional, Williamson, Elizabeth J., additional, McDonald, Helen I., additional, Tomlinson, Laurie A., additional, Wing, Kevin, additional, Grieve, Richard, additional, Grint, Daniel J., additional, Douglas, Ian J., additional, Evans, Stephen J.W., additional, Walker, Jemma L., additional, Cowling, Thomas E., additional, Herrett, Emily L., additional, Bates, Christopher, additional, Cockburn, Jonathan, additional, Parry, John, additional, Hester, Frank, additional, Harper, Sam, additional, O'Hanlon, Shaun, additional, Eavis, Alex, additional, Jarvis, Richard, additional, Avramov, Dima, additional, Griffiths, Paul, additional, Fowles, Aaron, additional, Parkes, Nasreen, additional, Nicholson, Brian, additional, Perera, Rafael, additional, Harrison, David, additional, Khunti, Kamlesh, additional, Sterne, Jonathan AC., additional, and Quint, Jennifer, additional

Published
2023
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24. NETWORK-BASED LESION IMPACT SCORE IS AN INDEPENDENT PREDICTOR OF POST-STROKE COGNITIVE IMPAIRMENT

Author

Biesbroek, J. Matthijs, Weaver, Nick A, Aben, Hugo P, Kuijf, Hugo J, Abrigo, Jill, Bae, Hee-Joon, Barbay, Mélanie, Best, Jonathan G, Bordet, Régis, Chappell, Francesca M., Chen, Christopher P.L.H., Dondaine, Thibaut, van der Giessen, Ruben S., Godefroy, Olivier, Verne, Jules, Gyanwali, Bibek, Hamilton, Olivia K.L., Hilal, Saima, Wajer, Irene M.C. Huenges, Kang, Yeonwook, Kappelle, L. Jaap, Kim, Beom Joon, Köhler, Sebastian, de Kort, Paul L.M., Koudstaal, Peter J., Kuchcinski, Gregory, Lam, Bonnie Y.K., Lee, Byung-Chul, Lee, Keon-Joo, Lim, Jae-Sung, Lopes, Renaud, Makin, Stephen D.J., Mendyk, Anne-Marie, Mok, Vincent C.T., Oh, Mi Sun, van Oostenbrugge, Robert J., Roussel, Martine, Shi, Lin, Staals, Julie, Valdés-Hernández, Maria del C., Venketasubramanian, Narayanaswamy, Verhey, Frans R.J., Wardlaw, Joanna M., Werring, David J., Xin, Xu, Yu, Kyung-Ho, van Zandvoort, Martine J.E., Zhao, Lei, and Biessels, Geert Jan

Published
2024
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25. Elements of power: Material-political entanglements in Australia's fossil fuel hegemony.

Author

Hamilton, Olivia, Nyberg, Daniel, and Bowden, Vanessa

Subjects
FOSSIL fuels, ENVIRONMENTAL activism, EXTREME weather, CLIMATE change, AGRICULTURAL meteorology, CLIMATE change & health, WILDFIRES
Abstract

Anthropocentric climate change presents an existential threat through impacts such as rising sea levels, effects on agricultural crops and extreme weather events. However, governments, businesses and communities struggle to wean off fossil fuel dependency. In this article, we argue that this is due to the grip of fossil fuel hegemony. To explain this grip, we draw on the theoretical perspectives of new materialism to examine how fossil fuels and politics interact in upholding Australia's fossil fuel regime. Our analysis, based on 70 qualitative interviews conducted with politicians and political advisors, fossil fuel executives and experts and environmental activists, shows three processes – establishment, entrenchment and encroachment – through which political-material entanglements lock in a fossil fuel-based future. These processes are both discursive, with politicians and industry downplaying, if not outright denying, the climate emergency and material, with investment in new mines and infrastructure even while the negative ecological impacts of fossil fuel use gather pace. [ABSTRACT FROM AUTHOR]

Published
2023
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28. Home working and social and mental wellbeing at different stages of the COVID-19 pandemic in the UK: Evidence from 7 longitudinal population surveys

Author

Jacques, Wels, Wielgoszewska, Bożena, Moltrecht, Bettina, Booth, Charlotte, Green, Michael J, Hamilton, Olivia KL, Demou, Evangelia, Gessa, Giorgio Di, Huggins, Charlotte, Zhu, Jingmin, Santorelli, Gillian, Silverwood, Richard J., Kopasker, Daniel, Shaw, Richard John, Hughes, Alun, Patalay, Praveetha, Steves, Claire, Chaturvedi, Nishi, Porteous, David, Rhead, Rebecca, Katikireddi, Srinivasa Vittal, Ploubidis, George, Jacques, Wels, Wielgoszewska, Bożena, Moltrecht, Bettina, Booth, Charlotte, Green, Michael J, Hamilton, Olivia KL, Demou, Evangelia, Gessa, Giorgio Di, Huggins, Charlotte, Zhu, Jingmin, Santorelli, Gillian, Silverwood, Richard J., Kopasker, Daniel, Shaw, Richard John, Hughes, Alun, Patalay, Praveetha, Steves, Claire, Chaturvedi, Nishi, Porteous, David, Rhead, Rebecca, Katikireddi, Srinivasa Vittal, and Ploubidis, George

Abstract

Background Home working has increased since the Coronavirus Disease 2019 (COVID-19) pandemic’s onset with concerns that it may have adverse health implications. We assessed the association between home working and social and mental wellbeing among the employed population aged 16 to 66 through harmonised analyses of 7 UK longitudinal studies. Methods and findings We estimated associations between home working and measures of psychological distress, low life satisfaction, poor self-rated health, low social contact, and loneliness across 3 different stages of the pandemic (T1 = April to June 2020 –first lockdown, T2 = July to October 2020 –eased restrictions, T3 = November 2020 to March 2021 –second lockdown) using modified Poisson regression and meta-analyses to pool results across studies. We successively adjusted the model for sociodemographic characteristics (e.g. age, sex), job characteristics (e.g. sector of activity, pre-pandemic home working propensities), and pre-pandemic health. Among respectively 10,367, 11,585, and 12,179 participants at T1, T2, and T3, we found higher rates of home working at T1 and T3 compared with T2, reflecting lockdown periods. Home working was not associated with psychological distress at T1 (RR = 0.92, 95% CI = 0.79 to 1.08) or T2 (RR = 0.99, 95% CI = 0.88 to 1.11), but a detrimental association was found with psychological distress at T3 (RR = 1.17, 95% CI = 1.05 to 1.30). Study limitations include the fact that pre-pandemic home working propensities were derived from external sources, no information was collected on home working dosage and possible reverse association between change in wellbeing and home working likelihood. Conclusions No clear evidence of an association between home working and mental wellbeing was found, apart from greater risk of psychological distress during the second lockdown, but differences across subgroups (e.g. by sex or level of education) may exist. Longer term shifts to home working might not have adve, SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2023

29. Associations between SARS-CoV-2 infection and subsequent economic inactivity and employment status: pooled analyses of five linked longitudinal surveys.

Author

Shaw, Richard John, Rhead, Rebecca, Silverwood, Richard J., Jacques, Wels, Zhu, Jingmin, Hamilton, Olivia Kl, Gessa, Giorgio Di, Bowyer, Ruth Ce, Moltrecht, Bettina, Green, Michael J, Demou, Evangelia, Pattaro, Serena, Zaninotto, Paola, Boyd, Andy, Greaves, Felix, Chaturvedi, Nish, Ploubidis, George B., Katikireddi, Srinivasa Vittal, Shaw, Richard John, Rhead, Rebecca, Silverwood, Richard J., Jacques, Wels, Zhu, Jingmin, Hamilton, Olivia Kl, Gessa, Giorgio Di, Bowyer, Ruth Ce, Moltrecht, Bettina, Green, Michael J, Demou, Evangelia, Pattaro, Serena, Zaninotto, Paola, Boyd, Andy, Greaves, Felix, Chaturvedi, Nish, Ploubidis, George B., and Katikireddi, Srinivasa Vittal

Abstract

Following the acute phase of the COVID-19 pandemic, record numbers of people became economically inactive (i.e. neither working nor looking for work), or non-employed (including unemployed job seekers and economically inactive people). A possible explanation is people leaving the workforce after contracting COVID-19. We investigated whether testing positive for SARS-CoV-2 is related to subsequent economic inactivity and non-employment, among people employed pre-pandemic., info:eu-repo/semantics/published

Published
2023

30. White Matter Hyperintensity Volume and Poststroke Cognition:An Individual Patient Data Pooled Analysis of 9 Ischemic Stroke Cohort Studies

Author

De Kort, Floor A.S., Coenen, Mirthe, Weaver, Nick A., Kuijf, Hugo J., Aben, Hugo P., Bae, Hee Joon, Bordet, Régis, Cammà, Guido, Chen, Christopher P.L.H., Dewenter, Anna, Duering, Marco, Fang, Rong, Van Der Giessen, Ruben S., Hamilton, Olivia K.L., Hilal, Saima, Huenges Wajer, Irene M.C., Kan, Cheuk Ni, Kim, Jonguk, Kim, Beom Joon, Köhler, Sebastian, De Kort, Paul L.M., Koudstaal, Peter J., Lim, Jae Sung, Lopes, Renaud, Mok, Vincent C.T., Staals, Julie, Venketasubramanian, Narayanaswamy, Verhagen, Charlotte M., Verhey, Frans R.J., Wardlaw, Joanna M., Xu, Xin, Yu, Kyung Ho, Biesbroek, J. Matthijs, Biessels, Geert Jan, De Kort, Floor A.S., Coenen, Mirthe, Weaver, Nick A., Kuijf, Hugo J., Aben, Hugo P., Bae, Hee Joon, Bordet, Régis, Cammà, Guido, Chen, Christopher P.L.H., Dewenter, Anna, Duering, Marco, Fang, Rong, Van Der Giessen, Ruben S., Hamilton, Olivia K.L., Hilal, Saima, Huenges Wajer, Irene M.C., Kan, Cheuk Ni, Kim, Jonguk, Kim, Beom Joon, Köhler, Sebastian, De Kort, Paul L.M., Koudstaal, Peter J., Lim, Jae Sung, Lopes, Renaud, Mok, Vincent C.T., Staals, Julie, Venketasubramanian, Narayanaswamy, Verhagen, Charlotte M., Verhey, Frans R.J., Wardlaw, Joanna M., Xu, Xin, Yu, Kyung Ho, Biesbroek, J. Matthijs, and Biessels, Geert Jan

Abstract

BACKGROUND: White matter hyperintensities (WMH) are associated with cognitive dysfunction after ischemic stroke. Yet, uncertainty remains about affected domains, the role of other preexisting brain injury, and infarct types in the relation between WMH burden and poststroke cognition. We aimed to disentangle these factors in a large sample of patients with ischemic stroke from different cohorts. METHODS: We pooled and harmonized individual patient data (n=1568) from 9 cohorts, through the Meta VCI Map consortium (www.metavcimap.org). Included cohorts comprised patients with available magnetic resonance imaging and multidomain cognitive assessment <15 months poststroke. In this individual patient data meta-analysis, linear mixed models were used to determine the association between WMH volume and domain-specific cognitive functioning (Z scores; attention and executive functioning, processing speed, language and verbal memory) for the total sample and stratified by infarct type. Preexisting brain injury was accounted for in the multivariable models and all analyses were corrected for the study site as a random effect. RESULTS: In the total sample (67 years [SD, 11.5], 40% female), we found a dose-dependent inverse relationship between WMH volume and poststroke cognitive functioning across all 4 cognitive domains (coefficients ranging from -0.09 [SE, 0.04, P=0.01] for verbal memory to -0.19 [SE, 0.03, P<0.001] for attention and executive functioning). This relation was independent of acute infarct volume and the presence of lacunes and old infarcts. In stratified analyses, the relation between WMH volume and domain-specific functioning was also largely independent of infarct type.CONCLUSIONS: In patients with ischemic stroke, increasing WMH volume is independently associated with worse cognitive functioning across all major domains, regardless of old ischemic lesions and infarct type.

Published
2023

31. Sex Differences in Poststroke Cognitive Impairment:A Multicenter Study in 2343 Patients With Acute Ischemic Stroke

Author

Exalto, Lieza G., Weaver, Nick A., Kuijf, Hugo J., Aben, Hugo P., Bae, Hee Joon, Best, Jonathan G., Bordet, Régis, Chen, Christopher P.L.H., van der Giessen, Ruben S., Godefroy, Olivier, Gyanwali, Bibek, Hamilton, Olivia K.L., Hilal, Saima, Huenges Wajer, Irene M.C., Kim, Jonguk, Kappelle, L. Jaap, Kim, Beom Joon, Köhler, Sebastian, de Kort, Paul L.M., Koudstaal, Peter J., Lim, Jae Sung, Makin, Stephen D.J., Mok, Vincent C.T., van Oostenbrugge, Robert J., Roussel, Martine, Staals, Julie, Valdés-Hernández, Maria Del C., Venketasubramanian, Narayanaswamy, Verhey, Frans R.J., Wardlaw, Joanna M., Werring, David J., Xu, Xin, van Zandvoort, Martine J.E., Biesbroek, J. Matthijs, Chappell, Francesca M., Biessels, Geert Jan, Exalto, Lieza G., Weaver, Nick A., Kuijf, Hugo J., Aben, Hugo P., Bae, Hee Joon, Best, Jonathan G., Bordet, Régis, Chen, Christopher P.L.H., van der Giessen, Ruben S., Godefroy, Olivier, Gyanwali, Bibek, Hamilton, Olivia K.L., Hilal, Saima, Huenges Wajer, Irene M.C., Kim, Jonguk, Kappelle, L. Jaap, Kim, Beom Joon, Köhler, Sebastian, de Kort, Paul L.M., Koudstaal, Peter J., Lim, Jae Sung, Makin, Stephen D.J., Mok, Vincent C.T., van Oostenbrugge, Robert J., Roussel, Martine, Staals, Julie, Valdés-Hernández, Maria Del C., Venketasubramanian, Narayanaswamy, Verhey, Frans R.J., Wardlaw, Joanna M., Werring, David J., Xu, Xin, van Zandvoort, Martine J.E., Biesbroek, J. Matthijs, Chappell, Francesca M., and Biessels, Geert Jan

Abstract

BACKGROUND: Poststroke cognitive impairment (PSCI) occurs in about half of stroke survivors. Cumulative evidence indicates that functional outcomes of stroke are worse in women than men. Yet it is unknown whether the occurrence and characteristics of PSCI differ between men and women. METHODS: Individual patient data from 9 cohorts of patients with ischemic stroke were harmonized and pooled through the Meta-VCI-Map consortium (n=2343, 38% women). We included patients with visible symptomatic infarcts on computed tomography/magnetic resonance imaging and cognitive assessment within 15 months after stroke. PSCI was defined as impairment in ≥1 cognitive domains on neuropsychological assessment. Logistic regression analyses were performed to compare men to women, adjusted for study cohort, to obtain odds ratios for PSCI and individual cognitive domains. We also explored sensitivity and specificity of cognitive screening tools for detecting PSCI, according to sex (Mini-Mental State Examination, 4 cohorts, n=1814; Montreal Cognitive Assessment, 3 cohorts, n=278). RESULTS: PSCI was found in 51% of both women and men. Men had a lower risk of impairment of attention and executive functioning (men: odds ratio, 0.76 [95% CI, 0.61-0.96]), and language (men: odds ratio, 0.67 [95% CI, 0.45-0.85]), but a higher risk of verbal memory impairment (men: odds ratio, 1.43 [95% CI, 1.17-1.75]). The sensitivity of Mini-Mental State Examination (<25) for PSCI was higher for women (0.53) than for men (0.27; P=0.02), with a lower specificity for women (0.80) than men (0.96; P=0.01). Sensitivity and specificity of Montreal Cognitive Assessment (<26.) for PSCI was comparable between women and men (0.91 versus 0.86; P=0.62 and 0.29 versus 0.28; P=0.86, respectively). CONCLUSIONS: Sex was not associated with PSCI occurrence but affected domains differed between men and women. The latter may explain why sensitivity of the Mini-Mental State Examination for detecting PSCI was higher in wom

Published
2023

32. White Matter Hyperintensity Volume and Poststroke Cognition: An Individual Patient Data Pooled Analysis of 9 Ischemic Stroke Cohort Studies

Author

Opleiding Neurologie, Beeldverwerking ISI, Brain, Cancer, Circulatory Health, Structure and Connections, Neurologie, Projectafdeling VCI, Neurologen, de Kort, Floor A S, Coenen, Mirthe, Weaver, Nick A, Kuijf, Hugo J, Aben, Hugo P, Bae, Hee-Joon, Bordet, Régis, Cammà, Guido, Chen, Christopher P L H, Dewenter, Anna, Duering, Marco, Fang, Rong, van der Giessen, Ruben S, Hamilton, Olivia K L, Hilal, Saima, Huenges Wajer, Irene M C, Kan, Cheuk Ni, Kim, Jonguk, Kim, Beom Joon, Köhler, Sebastian, de Kort, Paul L M, Koudstaal, Peter J, Lim, Jae-Sung, Lopes, Renaud, Mok, Vincent C T, Staals, Julie, Venketasubramanian, Narayanaswamy, Verhagen, Charlotte M, Verhey, Frans R J, Wardlaw, Joanna M, Xu, Xin, Yu, Kyung-Ho, Biesbroek, J Matthijs, Biessels, Geert Jan, Opleiding Neurologie, Beeldverwerking ISI, Brain, Cancer, Circulatory Health, Structure and Connections, Neurologie, Projectafdeling VCI, Neurologen, de Kort, Floor A S, Coenen, Mirthe, Weaver, Nick A, Kuijf, Hugo J, Aben, Hugo P, Bae, Hee-Joon, Bordet, Régis, Cammà, Guido, Chen, Christopher P L H, Dewenter, Anna, Duering, Marco, Fang, Rong, van der Giessen, Ruben S, Hamilton, Olivia K L, Hilal, Saima, Huenges Wajer, Irene M C, Kan, Cheuk Ni, Kim, Jonguk, Kim, Beom Joon, Köhler, Sebastian, de Kort, Paul L M, Koudstaal, Peter J, Lim, Jae-Sung, Lopes, Renaud, Mok, Vincent C T, Staals, Julie, Venketasubramanian, Narayanaswamy, Verhagen, Charlotte M, Verhey, Frans R J, Wardlaw, Joanna M, Xu, Xin, Yu, Kyung-Ho, Biesbroek, J Matthijs, and Biessels, Geert Jan

Published
2023

33. Sex Differences in Poststroke Cognitive Impairment: A Multicenter Study in 2343 Patients With Acute Ischemic Stroke

Author

Neurologen, Opleiding Neurologie, Beeldverwerking ISI, Brain, Cancer, Circulatory Health, Structure and Connections, Projectafdeling VCI, Neurologie, Neuropsychologie, Exalto, Lieza G, Weaver, Nick A, Kuijf, Hugo J, Aben, Hugo P, Bae, Hee-Joon, Best, Jonathan G, Bordet, Régis, Chen, Christopher P L H, van der Giessen, Ruben S, Godefroy, Olivier, Gyanwali, Bibek, Hamilton, Olivia K L, Hilal, Saima, Huenges Wajer, Irene M C, Kim, Jonguk, Kappelle, L Jaap, Kim, Beom Joon, Köhler, Sebastian, de Kort, Paul L M, Koudstaal, Peter J, Lim, Jae-Sung, Makin, Stephen D J, Mok, Vincent C T, van Oostenbrugge, Robert J, Roussel, Martine, Staals, Julie, Valdés-Hernández, Maria Del C, Venketasubramanian, Narayanaswamy, Verhey, Frans R J, Wardlaw, Joanna M, Werring, David J, Xu, Xin, van Zandvoort, Martine J E, Biesbroek, J Matthijs, Chappell, Francesca M, Biessels, Geert Jan, Neurologen, Opleiding Neurologie, Beeldverwerking ISI, Brain, Cancer, Circulatory Health, Structure and Connections, Projectafdeling VCI, Neurologie, Neuropsychologie, Exalto, Lieza G, Weaver, Nick A, Kuijf, Hugo J, Aben, Hugo P, Bae, Hee-Joon, Best, Jonathan G, Bordet, Régis, Chen, Christopher P L H, van der Giessen, Ruben S, Godefroy, Olivier, Gyanwali, Bibek, Hamilton, Olivia K L, Hilal, Saima, Huenges Wajer, Irene M C, Kim, Jonguk, Kappelle, L Jaap, Kim, Beom Joon, Köhler, Sebastian, de Kort, Paul L M, Koudstaal, Peter J, Lim, Jae-Sung, Makin, Stephen D J, Mok, Vincent C T, van Oostenbrugge, Robert J, Roussel, Martine, Staals, Julie, Valdés-Hernández, Maria Del C, Venketasubramanian, Narayanaswamy, Verhey, Frans R J, Wardlaw, Joanna M, Werring, David J, Xu, Xin, van Zandvoort, Martine J E, Biesbroek, J Matthijs, Chappell, Francesca M, and Biessels, Geert Jan

Published
2023

34. Association between home working and mental health by key worker status during the Covid-19 pandemic. Evidence from four British longitudinal studies

Author

Wielgoszewksa, Bożena, Booth, Charlotte, Green, Michael J., Hamilton, Olivia K.L., and Wels, Jacques

Subjects
Cohort Studies, Mental Health, Depression, Health, Toxicology and Mutagenesis, Public Health, Environmental and Occupational Health, COVID-19, Humans, Longitudinal Studies, Middle Aged, Pandemics
Abstract

Little is known about the relationship between homeworking and mental health during the Covid-19 pandemic and how it might differ by keyworker status. To understand this relationship, we use longitudinal data collected over three time points during the pandemic from three British cohort studies born in 1958 (National Child Development Study), 1970 (British Cohort Study) and 1989–90 (Next Step) as well as from a population-based study stratified by four age groups (Understanding Society). We estimate the association between life satisfaction, anxiety, depression, and psychological distress and homeworking by key worker status using mixed effects models with maximum likelihood estimation to account for repeated measurements across the pandemic, allowing intercepts to vary across individuals after controlling for a set of covariates including pre-pandemic home working propensities and loneliness. Results show that key workers working from home showed the greatest decline in mental health outcomes relative to other groups. Pre-pandemic homeworking did not significantly change the nature of such a relationship and loneliness slightly attenuated some of the effects. Finally, mental health outcomes varied across age-groups and time points. The discussion emphasises the need to pay attention to key workers when assessing the relationship between mental health and homeworking.

Published
2022

35. Antibody levels following vaccination against SARS-CoV-2: associations with post-vaccination infection and risk factors in two UK longitudinal studies

Author

Cheetham, Nathan J, primary, Kibble, Milla, additional, Wong, Andrew, additional, Silverwood, Richard J, additional, Knuppel, Anika, additional, Williams, Dylan M, additional, Hamilton, Olivia KL, additional, Lee, Paul H, additional, Bridger Staatz, Charis, additional, Di Gessa, Giorgio, additional, Zhu, Jingmin, additional, Katikireddi, Srinivasa Vittal, additional, Ploubidis, George B, additional, Thompson, Ellen J, additional, Bowyer, Ruth CE, additional, Zhang, Xinyuan, additional, Abbasian, Golboo, additional, Garcia, Maria Paz, additional, Hart, Deborah, additional, Seow, Jeffrey, additional, Graham, Carl, additional, Kouphou, Neophytos, additional, Acors, Sam, additional, Malim, Michael H, additional, Mitchell, Ruth E, additional, Northstone, Kate, additional, Major-Smith, Daniel, additional, Matthews, Sarah, additional, Breeze, Thomas, additional, Crawford, Michael, additional, Molloy, Lynn, additional, Kwong, Alex SF, additional, Doores, Katie, additional, chaturvedi, Nishi, additional, Duncan, Emma L, additional, Timpson, Nicholas J, additional, and Steves, Claire J, additional

Published
2023
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36. Socio-demographic determinants of COVID-19: a coordinated analysis of eight longitudinal studies and electronic health records

Author

Wels, Jacques, Hamilton, Olivia, Moltrecht, Bettina, Andrews, Colm, Rhead, Rebecca, Zhu, Jingmin, Bowyer, Ruth, Santorelli, Gillian, Maddock, Jane, Di Gessa, Giorgio, Silverwood, Richard, Chaturvedi, Nishi, Green, Michael, Shaw, Richard, Green, Mark, Steves, Claire, Katikireddi, Vittal, Ploubidis, George, and Wielgoszewska, Bozena

Subjects
Medicine and Health Sciences, Public Health
Abstract

Although everybody is at risk of catching SARS-Cov-2, recent research has shown that some people are more at risk than others because of personal characteristics or circumstances such as sex, ethnicity, or their financial situation. In this study, we aim to understand whether differences in peoples’ characteristics and circumstances increase their risk of catching SARS-Cov-2. To do this, we will use statistical models with data from eight research studies. We will also look at whether certain combinations of characteristics and circumstances increase someone’s risk of reporting COVID-19 disease symptoms. For example, we are interested in whether having different combinations of ethnic identity, sex and education increases or decreases the risk of reporting COVID-19 symptoms, or not. Since the core eight studies only include participants who signed up to our research studies, we will run similar analyses using a larger database, which contains health record data for up to 24 million people in England, to see if they find similar results. We hope that the results of this study will tell us which groups of people are at the highest risk of reporting COVID-19 symptoms. We will share the results of this study with policy makers and hope that it will guide decisions about how to support and protect the most vulnerable groups of people in our society.

Published
2023
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37. Coming of Age in a Pandemic: Transitions to Adulthood and Young Adult Mental Health

Author

Green, Michael, Hamilton, Olivia, Booth, Charlotte, McElroy, Eoin, Herbert, Annie, Katikireddi, Vittal, Wels, Jacques, Maddock, Jane, Ploubidis, George, and Moltrecht, Bettina

Subjects
Family, Life Course, and Society, Sociology, Mental and Social Health, Medicine and Health Sciences, Psychiatric and Mental Health, Medicine and Health, Social and Behavioral Sciences, FOS: Sociology
Abstract

The COVID-19 pandemic has disrupted people’s lives in many ways. For young people who were becoming adults, it may have disrupted or delayed moves out of education and into employment, or from living with parents to living with partners. This may have long-term implications for their lives and mental health. We will combine information from three surveys that followed people from their youth into adulthood before the pandemic, with information from a survey of young people who were just becoming adults as the COVID-19 pandemic happened. In doing so, we aim to find out what impact the COVID-19 pandemic has had on the economic and family situations of this generation of young adults, and what the longer-term impacts of this could be on their mental health.

Published
2022
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38. Author response: Antibody levels following vaccination against SARS-CoV-2: associations with post-vaccination infection and risk factors in two UK longitudinal studies

Author

Cheetham, Nathan J, primary, Kibble, Milla, additional, Wong, Andrew, additional, Silverwood, Richard J, additional, Knuppel, Anika, additional, Williams, Dylan M, additional, Hamilton, Olivia KL, additional, Lee, Paul H, additional, Bridger Staatz, Charis, additional, Di Gessa, Giorgio, additional, Zhu, Jingmin, additional, Katikireddi, Srinivasa Vittal, additional, Ploubidis, George B, additional, Thompson, Ellen J, additional, Bowyer, Ruth CE, additional, Zhang, Xinyuan, additional, Abbasian, Golboo, additional, Garcia, Maria Paz, additional, Hart, Deborah, additional, Seow, Jeffrey, additional, Graham, Carl, additional, Kouphou, Neophytos, additional, Acors, Sam, additional, Malim, Michael H, additional, Mitchell, Ruth E, additional, Northstone, Kate, additional, Major-Smith, Daniel, additional, Matthews, Sarah, additional, Breeze, Thomas, additional, Crawford, Michael, additional, Molloy, Lynn, additional, Kwong, Alex SF, additional, Doores, Katie, additional, Chaturvedi, Nishi, additional, Duncan, Emma L, additional, Timpson, Nicholas J, additional, and Steves, Claire J, additional

Published
2022
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40. Home working and its association with social and mental wellbeing at different stages of the COVID-19 pandemic: Evidence from seven UK longitudinal population surveys

Author

Wels, Jacques, primary, Wielgoszewska, Bożena, additional, Moltrecht, Bettina, additional, Booth, Charlotte, additional, Green, Michael J, additional, Hamilton, Olivia KL, additional, Demou, Evangelia, additional, Gessa, Giorgio Di, additional, Huggins, Charlotte, additional, Zhu, Jingmin, additional, Santorelli, Gillian, additional, Silverwood, Richard J., additional, Kopasker, Daniel, additional, Shaw, Richard J., additional, Hughes, Alun, additional, Patalay, Praveetha, additional, Steves, Claire, additional, Chaturvedi, Nish, additional, Porteous, David, additional, Rhead, Rebecca, additional, Katikireddi, Srinivasa Vittal, additional, and Ploubidis, George B., additional

Published
2022
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42. Associations of Peak-Width Skeletonized Mean Diffusivity and Post-Stroke Cognition

Author

Jochems, Angela C. C., primary, Muñoz Maniega, Susana, additional, Clancy, Una, additional, Jaime Garcia, Daniela, additional, Arteaga, Carmen, additional, Hewins, Will, additional, Penman, Rachel, additional, Hamilton, Olivia K. L., additional, Czechoń, Agnieszka, additional, Backhouse, Ellen V., additional, Thrippleton, Michael J., additional, Stringer, Michael S., additional, Bastin, Mark. E., additional, Valdés Hernández, Maria del C., additional, Wiseman, Stewart, additional, Chappell, Francesca M., additional, Doubal, Fergus N., additional, and Wardlaw, Joanna M., additional

Published
2022
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43. Seedborne Cercospora beticola Can Initiate Cercospora Leaf Spot from Sugar Beet (Beta vulgaris) Fruit Tissue

Author

Spanner, Rebecca, Neubauer, Jonathan, Heick, Thies M, Grusak, Michael A, Hamilton, Olivia, Rivera-Varas, Viviana, de Jonge, Ronnie, Pethybridge, Sarah, Webb, Kimberley M, Leubner-Metzger, Gerhard, Secor, Gary A, Bolton, Melvin D, Sub Plant-Microbe Interactions, and Plant Microbe Interactions

Subjects
etiology, Taverne, microbiome, fungal pathogens, Plant Science, Agronomy and Crop Science
Abstract

Cercospora leaf spot (CLS) is a globally important disease of sugar beet (Beta vulgaris) caused by the fungus Cercospora beticola. Long-distance movement of C. beticola has been indirectly evidenced in recent population genetic studies, suggesting potential dispersal via seed. Commercial sugar beet "seed" consists of the reproductive fruit (true seed surrounded by maternal pericarp tissue) coated in artificial pellet material. In this study, we confirmed the presence of viable C. beticola in sugar beet fruit for 10 of 37 tested seed lots. All isolates harbored the G143A mutation associated with quinone outside inhibitor resistance, and 32 of 38 isolates had reduced demethylation inhibitor sensitivity (EC50 > 1 µg/ml). Planting of commercial sugar beet seed demonstrated the ability of seedborne inoculum to initiate CLS in sugar beet. C. beticola DNA was detected in DNA isolated from xylem sap, suggesting the vascular system is used to systemically colonize the host. We established nuclear ribosomal internal transcribed spacer region amplicon sequencing using the MinION platform to detect fungi in sugar beet fruit. Fungal sequences from 19 different genera were identified from 11 different sugar beet seed lots, but Fusarium, Alternaria, and Cercospora were consistently the three most dominant taxa, comprising an average of 93% relative read abundance over 11 seed lots. We also present evidence that C. beticola resides in the pericarp of sugar beet fruit rather than the true seed. The presence of seedborne inoculum should be considered when implementing integrated disease management strategies for CLS of sugar beet in the future.

Published
2022

44. Seedborne Cercospora beticola Can Initiate Cercospora Leaf Spot from Sugar Beet (Beta vulgaris) Fruit Tissue

Author

Sub Plant-Microbe Interactions, Plant Microbe Interactions, Spanner, Rebecca, Neubauer, Jonathan, Heick, Thies M, Grusak, Michael A, Hamilton, Olivia, Rivera-Varas, Viviana, de Jonge, Ronnie, Pethybridge, Sarah, Webb, Kimberley M, Leubner-Metzger, Gerhard, Secor, Gary A, Bolton, Melvin D, Sub Plant-Microbe Interactions, Plant Microbe Interactions, Spanner, Rebecca, Neubauer, Jonathan, Heick, Thies M, Grusak, Michael A, Hamilton, Olivia, Rivera-Varas, Viviana, de Jonge, Ronnie, Pethybridge, Sarah, Webb, Kimberley M, Leubner-Metzger, Gerhard, Secor, Gary A, and Bolton, Melvin D

Published
2022

46. Network impact score is an independent predictor of post-stroke cognitive impairment:A multicenter cohort study in 2341 patients with acute ischemic stroke

Author

Biesbroek, J. Matthijs, Weaver, Nick A., Aben, Hugo P., Kuijf, Hugo J., Abrigo, Jill, Bae, Hee Joon, Barbay, Mélanie, Best, Jonathan G., Bordet, Régis, Chappell, Francesca M., Chen, Christopher P.L.H., Dondaine, Thibaut, van der Giessen, Ruben S., Godefroy, Olivier, Gyanwali, Bibek, Hamilton, Olivia K.L., Hilal, Saima, Huenges Wajer, Irene M.C., Kang, Yeonwook, Kappelle, L. Jaap, Kim, Beom Joon, Köhler, Sebastian, de Kort, Paul L.M., Koudstaal, Peter J., Kuchcinski, Gregory, Lam, Bonnie Y.K., Lee, Byung Chul, Lee, Keon Joo, Lim, Jae Sung, Lopes, Renaud, Makin, Stephen D.J., Mendyk, Anne Marie, Mok, Vincent C.T., Oh, Mi Sun, van Oostenbrugge, Robert J., Roussel, Martine, Shi, Lin, Staals, Julie, Valdés-Hernández, Maria del C., Venketasubramanian, Narayanaswamy, Verhey, Frans R.J., Wardlaw, Joanna M., Werring, David J., Xin, Xu, Yu, Kyung Ho, van Zandvoort, Martine J.E., Zhao, Lei, Biessels, Geert Jan, Biesbroek, J. Matthijs, Weaver, Nick A., Aben, Hugo P., Kuijf, Hugo J., Abrigo, Jill, Bae, Hee Joon, Barbay, Mélanie, Best, Jonathan G., Bordet, Régis, Chappell, Francesca M., Chen, Christopher P.L.H., Dondaine, Thibaut, van der Giessen, Ruben S., Godefroy, Olivier, Gyanwali, Bibek, Hamilton, Olivia K.L., Hilal, Saima, Huenges Wajer, Irene M.C., Kang, Yeonwook, Kappelle, L. Jaap, Kim, Beom Joon, Köhler, Sebastian, de Kort, Paul L.M., Koudstaal, Peter J., Kuchcinski, Gregory, Lam, Bonnie Y.K., Lee, Byung Chul, Lee, Keon Joo, Lim, Jae Sung, Lopes, Renaud, Makin, Stephen D.J., Mendyk, Anne Marie, Mok, Vincent C.T., Oh, Mi Sun, van Oostenbrugge, Robert J., Roussel, Martine, Shi, Lin, Staals, Julie, Valdés-Hernández, Maria del C., Venketasubramanian, Narayanaswamy, Verhey, Frans R.J., Wardlaw, Joanna M., Werring, David J., Xin, Xu, Yu, Kyung Ho, van Zandvoort, Martine J.E., Zhao, Lei, and Biessels, Geert Jan

Abstract

Background: Post-stroke cognitive impairment (PSCI) is a common consequence of stroke. Accurate prediction of PSCI risk is challenging. The recently developed network impact score, which integrates information on infarct location and size with brain network topology, may improve PSCI risk prediction. Aims: To determine if the network impact score is an independent predictor of PSCI, and of cognitive recovery or decline. Methods: We pooled data from patients with acute ischemic stroke from 12 cohorts through the Meta VCI Map consortium. PSCI was defined as impairment in ≥ 1 cognitive domain on neuropsychological examination, or abnormal Montreal Cognitive Assessment. Cognitive recovery was defined as conversion from PSCI < 3 months post-stroke to no PSCI at follow-up, and cognitive decline as conversion from no PSCI to PSCI. The network impact score was related to serial measures of PSCI using Generalized Estimating Equations (GEE) models, and to PSCI stratified according to post-stroke interval (<3, 3–12, 12–24, >24 months) and cognitive recovery or decline using logistic regression. Models were adjusted for age, sex, education, prior stroke, infarct volume, and study site. Results: We included 2341 patients with 4657 cognitive assessments. PSCI was present in 398/844 patients (47%) <3 months, 709/1640 (43%) at 3–12 months, 243/853 (28%) at 12–24 months, and 208/522 (40%) >24 months. Cognitive recovery occurred in 64/181 (35%) patients and cognitive decline in 26/287 (9%). The network impact score predicted PSCI in the univariable (OR 1.50, 95%CI 1.34–1.68) and multivariable (OR 1.27, 95%CI 1.10–1.46) GEE model, with similar ORs in the logistic regression models for specified post-stroke intervals. The network impact score was not associated with cognitive recovery or decline. Conclusions: The network impact score is an independent predictor of PSCI. As such, the network impact score may contribute to a more precise and individualized cognitive pro

Published
2022

47. Network impact score is an independent predictor of post-stroke cognitive impairment: A multicenter cohort study in 2341 patients with acute ischemic stroke

Author

Projectafdeling VCI, Brain, Opleiding Neurologie, Beeldverwerking ISI, Circulatory Health, Cancer, Neurologie, Neurologen, Neuropsychologie, Structure and Connections, Biesbroek, J Matthijs, Weaver, Nick A, Aben, Hugo P, Kuijf, Hugo J, Abrigo, Jill, Bae, Hee-Joon, Barbay, Mélanie, Best, Jonathan G, Bordet, Régis, Chappell, Francesca M, Chen, Christopher P L H, Dondaine, Thibaut, van der Giessen, Ruben S, Godefroy, Olivier, Gyanwali, Bibek, Hamilton, Olivia K L, Hilal, Saima, Huenges Wajer, Irene M C, Kang, Yeonwook, Kappelle, L Jaap, Kim, Beom Joon, Köhler, Sebastian, de Kort, Paul L M, Koudstaal, Peter J, Kuchcinski, Gregory, Lam, Bonnie Y K, Lee, Byung-Chul, Lee, Keon-Joo, Lim, Jae-Sung, Lopes, Renaud, Makin, Stephen D J, Mendyk, Anne-Marie, Mok, Vincent C T, Oh, Mi Sun, van Oostenbrugge, Robert J, Roussel, Martine, Shi, Lin, Staals, Julie, Valdés-Hernández, Maria Del C, Venketasubramanian, Narayanaswamy, Verhey, Frans R J, Wardlaw, Joanna M, Werring, David J, Xin, Xu, Yu, Kyung-Ho, van Zandvoort, Martine J E, Zhao, Lei, Biessels, Geert Jan, Projectafdeling VCI, Brain, Opleiding Neurologie, Beeldverwerking ISI, Circulatory Health, Cancer, Neurologie, Neurologen, Neuropsychologie, Structure and Connections, Biesbroek, J Matthijs, Weaver, Nick A, Aben, Hugo P, Kuijf, Hugo J, Abrigo, Jill, Bae, Hee-Joon, Barbay, Mélanie, Best, Jonathan G, Bordet, Régis, Chappell, Francesca M, Chen, Christopher P L H, Dondaine, Thibaut, van der Giessen, Ruben S, Godefroy, Olivier, Gyanwali, Bibek, Hamilton, Olivia K L, Hilal, Saima, Huenges Wajer, Irene M C, Kang, Yeonwook, Kappelle, L Jaap, Kim, Beom Joon, Köhler, Sebastian, de Kort, Paul L M, Koudstaal, Peter J, Kuchcinski, Gregory, Lam, Bonnie Y K, Lee, Byung-Chul, Lee, Keon-Joo, Lim, Jae-Sung, Lopes, Renaud, Makin, Stephen D J, Mendyk, Anne-Marie, Mok, Vincent C T, Oh, Mi Sun, van Oostenbrugge, Robert J, Roussel, Martine, Shi, Lin, Staals, Julie, Valdés-Hernández, Maria Del C, Venketasubramanian, Narayanaswamy, Verhey, Frans R J, Wardlaw, Joanna M, Werring, David J, Xin, Xu, Yu, Kyung-Ho, van Zandvoort, Martine J E, Zhao, Lei, and Biessels, Geert Jan

Published
2022

48. Interior Imaginings: Centring curiosity and imagination as key design tools in first year.

Author

Hamilton, Olivia, Ying-Lan Dann, and Geck, Kate

Subjects
COVID-19 pandemic, CURIOSITY, IMAGINATION, INTERIOR decoration, LEARNING communities
Abstract

This project case study, Interior Imaginings, is an interior design studio that explores how imagination and curiosity can be actively developed in students early in their education and the benefit of this emphasis during online delivery during the Covid-19 pandemic. Carla Cesares’ text, ‘The Habit of Curiosity’, empowered students to identify and hone their individual and curiosity-driven processes, and the project demonstrated how curiosity can enliven practice within restricted circumstances. The focus on students’ individual curiosity sustained engagement across a diverse learning community and developed how the students understood themselves as tertiary design learners and future design practitioners. [ABSTRACT FROM AUTHOR]

Published
2023

49. Antibody levels following vaccination against SARS-CoV-2: associations with post-vaccination infection and risk factors

Author

Cheetham, Nathan J., primary, Kibble, Milla, additional, Wong, Andrew, additional, Silverwood, Richard J., additional, Knuppel, Anika, additional, Williams, Dylan M., additional, Hamilton, Olivia K. L., additional, Lee, Paul H., additional, Staatz, Charis Bridger, additional, Gessa, Giorgio Di, additional, Zhu, Jingmin, additional, Katikireddi, Srinivasa Vittal, additional, Ploubidis, George B., additional, Thompson, Ellen J., additional, Bowyer, Ruth C. E., additional, Zhang, Xinyuan, additional, Abbasian, Golboo, additional, Garcia, Maria Paz, additional, Hart, Deborah, additional, Seow, Jeffrey, additional, Graham, Carl, additional, Kouphou, Neophytos, additional, Acors, Sam, additional, Malim, Michael H., additional, Mitchell, Ruth E., additional, Northstone, Kate, additional, Major-Smith, Daniel, additional, Matthews, Sarah, additional, Breeze, Thomas, additional, Crawford, Michael, additional, Molloy, Lynn, additional, Kwong, Alex S. F., additional, Doores, Katie J., additional, Chaturvedi, Nishi, additional, Duncan, Emma L., additional, Timpson, Nicholas J., additional, and Steves, Claire J., additional

Published
2022
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