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1. Single cell atlas of human gastric muscle immune cells and macrophage-driven changes in idiopathic gastroparesis

Author

Chikkamenahalli, Lakshmikanth L., Jessen, Erik, Bernard, Cheryl E., Ip, W.K. Eddie, Breen-Lyles, Margaret, Cipriani, Gianluca, Pullapantula, Suraj R., Li, Ying, AlAsfoor, Shefaa, Wilson, Laura, Koch, Kenneth L., Kuo, Braden, Shulman, Robert J., Chumpitazi, Bruno P., McKenzie, Travis J., Kellogg, Todd A., Tonascia, James, Hamilton, Frank A., Sarosiek, Irene, McCallum, Richard, Parkman, Henry P., Pasricha, Pankaj J., Abell, Thomas L., Farrugia, Gianrico, Dasari, Surendra, and Grover, Madhusudan

Published
2024
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2. Advancing patient care through the Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR)

Author

Aceves, Seema, Collins, Margaret H, Rothenberg, Marc E, Furuta, Glenn T, Gonsalves, Nirmala, Researchers, Consortium of Eosinophilic Gastrointestinal Disease, Abonia, J Pablo, Almonte, Samuel, Andrews, Rachel, Arrington, Ashley, Arva, Nicoleta, Atkins, Fred, Bailey, Dominique, Berry, Alexis, Besl, Bridget, Bolton, Scott, Bonis, Peter, Book, Wendy, Bray, Kimberly, Brown, Teresa, Burger, Cassandra, Burke, Deirdre, Cahoon, Jonathon, Capocelli, Kelley, Chehade, Mirna, Collins, Margaret, Davis, Carla, Dellon, Evan, DeMarshall, Maureen, DiTommaso, Lauren, Dohil, Ranjan, Eby, Michael, Falk, Gary, Fleischer, David, Foote, Heather, Foss, Kelci, Friedlander, Joel, Fulkerson, Patricia, Furuta, Glenn, Geno, Debra, Greuter, Thomas, Gupta, Sandeep, Hamilton, Frank, Harris, Kirk, Harris, Jennifer, Hirano, Ikuo, Hiremath, Girish, Holland-Thomas, Nicole, Jacinto, Lea, Kagalwalla, Amir, Kaseta, Timothy, Katzka, David, Keeley, Kaitlin, Khosh-Hemmat, Emad, Khoury, Paneez, King, Eileen, Kliewer, Kara, Klion, Amy, Knowles, Jennifer, Kocher, Kendra, Kodroff, Ellyn, Krischer, Jeffrey, Kyle, Shay, Leung, John, Levy, Meredith, Liacouras, Chris, Mack, Denise, Martin, Lisa, Martin, Ellen, McCright-Gill, Talaya, Menard-Katcher, Paul, Menard-Katcher, Calies, Mendoza, Gabriela, Mingler, Melissa, Minnicozzi, Mike, Muir, Amanda, Mukkada, Vincent, MurrayPetzold, Cristin, Newbury, Robert, Nhu, Quan, Oyibo, Oghenekpaobor, Paliana, Allisa, Pan, Zhaoxing, Pesek, Robbie, Peterson, Kathryn, Poppendeck, Heidi, Putnam, Philip, Rivera, Fabian, Rothenberg, Marc, Rudman-Spergel, Amanda, Sable, Kathleen, Schoepfer, Alain, Scott, Melissa, Sheridan, Rachel, Sinanovic, Selma, Spergel, Jonathan, Strobel, MaryJo, and Sun, Kiki

Subjects
Biomedical and Clinical Sciences, Immunology, Clinical Research, Digestive Diseases, Clinical Trials and Supportive Activities, Evaluation of treatments and therapeutic interventions, Detection, screening and diagnosis, 6.9 Resources and infrastructure (treatment evaluation), 4.5 Resources and infrastructure (detection), Good Health and Well Being, Biomedical Research, Clinical Trials as Topic, Enteritis, Eosinophilia, Eosinophilic Esophagitis, Gastritis, National Institutes of Health (U.S.), United States, Eosinophils, gastrointestinal, consortium, allergy, esophagitis, advocacy, Consortium of Eosinophilic Gastrointestinal Disease Researchers, Allergy
Abstract

Recent advances in rare disease research are accelerated by the work of consortia that have been supported by the National Institutes of Health. Development of such consortia rely on multidisciplinary relationships and engagement with patient advocacy groups, as well as the National Institutes of Health and industry and academic partners. In this rostrum we present the development of such a process that focuses on eosinophilic gastrointestinal diseases. Principal investigators, patient advocacy groups, research assistants, and trainees work together to perform natural history studies that promote clinical trial readiness tools, conduct clinical trials, train a new generation of investigators, and perform innovative pilot studies.

Published
2020

3. Progress in Gastroparesis - A Narrative Review of the Work of the Gastroparesis Clinical Research Consortium

Author

Pasricha, Pankaj J., Grover, Madhusudan, Yates, Katherine P., Abell, Thomas L., Koch, Kenneth L., McCallum, Richard W., Sarosiek, Irene, Bernard, Cheryl E., Kuo, Braden, Bulat, Robert, Shulman, Robert J., Chumpitazi, Bruno P., Tonascia, James, Miriel, Laura A., Wilson, Laura A., Van Natta, Mark L., Mitchell, Emily, Hamilton, Frank, Farrugia, Gianrico, and Parkman, Henry P.

Published
2022
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4. SpHincterotomy for Acute Recurrent Pancreatitis Randomized Trial: Rationale, Methodology, and Potential Implications.

Author

Coté, Gregory A, Durkalski-Mauldin, Valerie L, Serrano, Jose, Klintworth, Erin, Williams, April W, Cruz-Monserrate, Zobeida, Arain, Mustafa, Buxbaum, James L, Conwell, Darwin L, Fogel, Evan L, Freeman, Martin L, Gardner, Timothy B, van Geenen, Erwin, Groce, J Royce, Jonnalagadda, Sreenivasa S, Keswani, Rajesh N, Menon, Shyam, Moffatt, Dana C, Papachristou, Georgios I, Ross, Andrew, Tarnasky, Paul R, Wang, Andrew Y, Wilcox, C Mel, Hamilton, Frank, and Yadav, Dhiraj

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Trials and Supportive Activities, Prevention, Digestive Diseases, Clinical Research, Oral and gastrointestinal, Adult, Cholangiopancreatography, Endoscopic Retrograde, Cholangiopancreatography, Magnetic Resonance, Cohort Studies, Endosonography, Female, Humans, Internationality, Male, Outcome Assessment, Health Care, Pancreas, Pancreatitis, Recurrence, Risk Factors, Secondary Prevention, Sphincterotomy, Endoscopic, acute pancreatitis, acute recurrent pancreatitis, chronic pancreatitis, endoscopic retrograde cholangiopancreatography, pancreas divisum, SHARP Consortium, Gastroenterology & Hepatology, Clinical sciences
Abstract

ObjectivesIn patients with acute recurrent pancreatitis (ARP), pancreas divisum, and no other etiologic factors, endoscopic retrograde cholangiopancreatography (ERCP) with minor papilla endoscopic sphincterotomy (miES) is often performed to enlarge the minor papillary orifice, based on limited data. The aims of this study are to describe the rationale and methodology of a sham-controlled clinical trial designed to test the hypothesis that miES reduces the risk of acute pancreatitis.MethodsThe SpHincterotomy for Acute Recurrent Pancreatitis (SHARP) trial is a multicenter, international, sham-controlled, randomized trial comparing endoscopic ultrasound + ERCP with miES versus endoscopic ultrasound + sham for the management of ARP. A total of 234 consented patients having 2 or more discrete episodes of acute pancreatitis, pancreas divisum confirmed by magnetic resonance cholangiopancreatography, and no other clear etiology for acute pancreatitis will be randomized. Both cohorts will be followed for a minimum of 6 months and a maximum of 48 months.ResultsThe trial is powered to detect a 33% risk reduction of acute pancreatitis frequency.ConclusionsThe SHARP trial will determine whether ERCP with miES benefits patients with idiopathic ARP and pancreas divisum. Trial planning has informed the importance of blinded outcome assessors and long-term follow-up.

Published
2019

5. Evaluating Eosinophilic Colitis as a Unique Disease Using Colonic Molecular Profiles: A Multi-Site Study

Author

Pablo Abonia, J., Aceves, Seema, Almonte, Samuel, Andrews, Rachel, Anvari, Sara, Arrington, Ashley, Arva, Nicoleta, Atkins, Fred, Bailey, Dominique, Berry, Alexis, Besl, Bridget, Bolton, Scott, Bonis, Peter, Book, Wendy, Bray, Kimberly, Brown, Teresa, Burger, Cassandra, Burke, Deirdre, Cahoon, Jonathon, Capocelli, Kelley, Chehade, Mirna, Chiou, Eric, Collins, Margaret, Davis, Carla, Dellon, Evan, DeMarshall, Maureen, DiTommaso, Lauren, Dohil, Ranjan, Eby, Michael, Falk, Gary, Fleischer, David, Foote, Heather, Foss, Kelci, Friedlander, Joel, Fulkerson, Patricia, Furuta, Glenn, Geno, Debra, Gonsalves, Nirmala, Greuter, Thomas, Gupta, Sandeep, Hamilton, Frank, Harris, Kirk, Harris, Jennifer, Hirano, Ikuo, Hiremath, Girish, Holland-Thomas, Nicole, Jacinto, Lea, Kagalwalla, Amir, Kaseta, Timothy, Katzka, David, Keeley, Kaitlin, Khosh-Hemmat, Emad, Khoury, Paneez, King, Eileen, Kliewer, Kara, Klion, Amy, Knowles, Jennifer, Kocher, Kendra, Kodroff, Ellyn, Krischer, Jeffrey, Kyle, Shay, Leung, John, Levy, Meredith, Liacouras, Chris, Mack, Denise, Martin, Lisa, Martin, Ellen, McCright-Gill, Talaya, Menard-Katcher, Paul, Menard-Katcher, Calies, Mendoza, Gabriela, Mingler, Melissa, Minnicozzi, Mike, Muir, Amanda, Mukkada, Vincent, Murray-Petzold, Cristin, Newbury, Robert, Nhu, Quan, Olive, Anthony, Oyibo, Oghenekpaobor (Joel), Paliana, Allisa, Pan, Zhaoxing, Pesek, Robbie, Peterson, Kathryn, Poppendeck, Heidi, Putnam, Philip, Rivera, Fabian, Rothenberg, Marc, Spergel, Amanda Rudman, Sable, Kathleen, Schoepfer, Alain, Scott, Melissa, Sheridan, Rachel, Sinanovic, Selma, Spergel, Jonathan, Strobel, Mary Jo, Sun, Kiki, Tasco, Amy, Tholen, Crystal, Thompson, Katherine, Tomkinson, Tiffany, Tran, Daisy, Tylicki, Alexandra, Urv, Tiina, Wang, Mei-Lun, Wechsler, Joshua, Wershil, Barry, Wheatley, Lisa, Wilkey, Leah, Yang, Guang-Yu, Zalewski, Angelika, Zicarelli, Amy, Shoda, Tetsuo, Collins, Margaret H., Rochman, Mark, Wen, Ting, Caldwell, Julie M., Mack, Lydia E., Osswald, Garrett A., Besse, John A., Haberman, Yael, Aceves, Seema S., Arva, Nicoleta C., Capocelli, Kelley E., Davis, Carla M., Dellon, Evan S., Falk, Gary W., Gupta, Sandeep K., Mukkada, Vincent A., Putnam, Philip E., Spergel, Jonathan M., Wechsler, Joshua B., Furuta, Glenn T., Denson, Lee A., and Rothenberg, Marc E.

Published
2022
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8. Loss of Endothelial TSPAN12 Promotes Fibrostenotic Eosinophilic Esophagitis via Endothelial Cell–Fibroblast Crosstalk

Author

Abonia, J. Pablo, Aceves, Seema, Almonte, Samuel, Andrews, Rachel, Arrington, Ashley, Arva, Nicoleta, Atkins, Fred, Bailey, Dominique, Berry, Alexis, Besl, Bridget, Bolton, Scott, Bonis, Peter, Book, Wendy, Bray, Kimberly, Brown, Teresa, Burger, Cassandra, Burke, Deirdre, Cahoon, Jonathon, Capocelli, Kelley, Chehade, Mirna, Collins, Margaret, Davis, Carla, Dellon, Evan, DeMarshall, Maureen, DiTommaso, Lauren, Dohil, Ranjan, Eby, Michael, Falk, Gary, Fleischer, David, Foote, Heather, Foss, Kelci, Friedlander, Joel, Fulkerson, Patricia, Furuta, Glenn, Geno, Debra, Gonsalves, Nirmala, Greuter, Thomas, Gupta, Sandeep, Hamilton, Frank, Harris, Kirk, Harris, Jennifer, Hirano, Ikuo, Hiremath, Girish, Holland-Thomas, Nicole, Jacinto, Lea, Kagalwalla, Amir, Kaseta, Timothy, Katzka, David, Keeley, Kaitlin, Khosh-Hemmat, Emad, Khoury, Paneez, King, Eileen, Kliewer, Kara, Klion, Amy, Knowles, Jennifer, Kocher, Kendra, Kodroff, Ellyn, Krischer, Jeffrey, Kyle, Shay, Leung, John, Levy, Meredith, Liacouras, Chris, Mack, Denise, Martin, Lisa, Martin, Ellen, McCright-Gill, Talaya, Menard-Katcher, Paul, Menard-Katcher, Calies, Mendoza, Gabriela, Mingler, Melissa, Minnicozzi, Mike, Muir, Amanda, Mukkada, Vincent, MurrayPetzold, Cristin, Newbury, Robert, Nhu, Quan, Oyibo, Oghenekpaobor (Joel), Paliana, Allisa, Pan, Zhaoxing, Pesek, Robbie, Peterson, Kathryn, Poppendeck, Heidi, Putnam, Philip, Rivera, Fabian, Rothenberg, Marc, Spergel, Amanda Rudman, Sable, Kathleen, Schoepfer, Alain, Scott, Melissa, Sheridan, Rachel, Sinanovic, Selma, Spergel, Jonathan, Strobel, MaryJo, Sun, Kiki, Tasco, Amy, Tholen, Crystal, Thompson, Katherine, Tomkinson, Tiffany, Tran, Daisy, Tylicki, Alexandra, Urv, Tiina, Wang, Mei-Lun, Wechsler, Joshua, Wershil, Barry, Wheatley, Lisa, Wilkey, Leah, Yang, Guang-Yu, Zalewski, Angelika, Zicarelli, Amy, Shoda, Tetsuo, Wen, Ting, Caldwell, Julie M., Ben-Baruch Morgenstern, Netali, Osswald, Garrett A., Rochman, Mark, Mack, Lydia E., Felton, Jennifer M., Arva, Nicoleta C., Atkins, Dan, Bonis, Peter A., Capocelli, Kelley E., Collins, Margaret H., Dellon, Evan S., Falk, Gary W., Gupta, Sandeep K., Menard-Katcher, Paul A., Mukkada, Vincent A., Putnam, Philip E., Rudman Spergel, Amanda K., Spergel, Jonathan M., Wechsler, Joshua B., Aceves, Seema S., Furuta, Glenn T., and Rothenberg, Marc E.

Published
2022
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9. Off-label-dosing of non-vitamin K-dependent oral antagonists in AF patients before and after stroke: results of the prospective multicenter Berlin Atrial Fibrillation Registry

Author

Tütüncü, Serdar, Olma, Manuel, Kunze, Claudia, Dietzel, Joanna, Schurig, Johannes, Fiessler, Cornelia, Malsch, Carolin, Haas, Tobias Eberhard, Dimitrijeski, Boris, Doehner, Wolfram, Hagemann, Georg, Hamilton, Frank, Honermann, Martin, Jungehulsing, Gerhard Jan, Kauert, Andreas, Koennecke, Hans-Christian, Mackert, Bruno-Marcel, Nabavi, Darius, Nolte, Christian H., Reis, Joschua Mirko, Schmehl, Ingo, Sparenberg, Paul, Stingele, Robert, Völzke, Enrico, Waldschmidt, Carolin, Zeise-Wehry, Daniel, Heuschmann, Peter U., Endress, Matthias, and Haeusler, Karl Georg

Published
2022
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10. Opioid Use and Potency Are Associated With Clinical Features, Quality of Life, and Use of Resources in Patients With Gastroparesis

Author

Pasricha, Pankaj Jay, Clarke, John, Kim, Yale, Nguyen, Linda, Ullah, Nighat, Snape, William, DeVole, Nata, Greene, Mary, Lee, Candice, Ponsetto, Courtney, Shetler, Katerina, Parkman, Henry P., Kantor, Steven, Lytes, Vanessa, Palit, Amiya, Simmons, Kellie, McCallum, Richard W., Hejazi, Reza, Roeser, Kathy, Sarosiek, Irene, Vasquez, Denise, Vega, Natalia, Abell, Thomas, Beatty, Karen, Hatter, Lisa, Howard, Ronna, Nowotny, Lindsay, Tang, Shou, Amin, Om S., Henry, Olivia, Kedar, Archana, McNair, Valerie, Pruett, Susanne, Smith, Margaret, Spree, Danielle, Hasler, William, Castle, Michelle, Coleski, Radoslav, Wootten, Sophanara, Koch, Kenneth, Baxter, Lynn, Brown, Anya, Culler, Samantha, Hooker, Judy, Stuart, Paula, Farrugia, Gianrico, Grover, Madhusudan, Bernard, Cheryl, Calles-Escandon, Jorge, Serrano, Jose, Hamilton, Frank, James, Steven, Torrance, Rebecca, Van Raaphorst, Rebekah, Tonascia, James, Belt, Patricia, Hallinan, Erin Corless, Colvin, Ryan, Donithan, Michele, Green, Mika, Isaacson, Milana, Kim, Wana, Lee, Linda, May, Patrick, Miriel, Laura, Sternberg, Alice, Van Natta, Mark, Vaughn, Ivana, Wilson, Laura, Yates, Katherine, Hasler, William L., Wilson, Laura A., Nguyen, Linda A., Snape, William J., Abell, Thomas L., Koch, Kenneth L., Pasricha, Pankaj J., Lee, Linda A., and Hamilton, Frank A.

Published
2019
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11. Advancing patient care through the Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR)

Author

Abonia, J. Pablo, Aceves, Seema, Almonte, Samuel, Andrews, Rachel, Arrington, Ashley, Arva, Nicoleta, Atkins, Fred, Bailey, Dominique, Berry, Alexis, Besl, Bridget, Bolton, Scott, Bonis, Peter, Book, Wendy, Bray, Kimberly, Brown, Teresa, Burger, Cassandra, Burke, Deirdre, Cahoon, Jonathon, Capocelli, Kelley, Chehade, Mirna, Collins, Margaret, Davis, Carla, Dellon, Evan, DeMarshall, Maureen, DiTommaso, Lauren, Dohil, Ranjan, Eby, Michael, Falk, Gary, Fleischer, David, Foote, Heather, Foss, Kelci, Friedlander, Joel, Fulkerson, Patricia, Furuta, Glenn, Geno, Debra, Gonsalves, Nirmala, Greuter, Thomas, Gupta, Sandeep, Hamilton, Frank, Harris, Kirk, Harris, Jennifer, Hirano, Ikuo, Hiremath, Girish, Holland-Thomas, Nicole, Jacinto, Lea, Kagalwalla, Amir, Kaseta, Timothy, Katzka, David, Keeley, Kaitlin, Khosh-Hemmat, Emad, Khoury, Paneez, King, Eileen, Kliewer, Kara, Klion, Amy, Knowles, Jennifer, Kocher, Kendra, Kodroff, Ellyn, Krischer, Jeffrey, Kyle, Shay, Leung, John, Levy, Meredith, Liacouras, Chris, Mack, Denise, Martin, Lisa, Martin, Ellen, McCright-Gill, Talaya, Menard-Katcher, Paul, Menard-Katcher, Calies, Mendoza, Gabriela, Mingler, Melissa, Minnicozzi, Mike, Muir, Amanda, Mukkada, Vincent, MurrayPetzold, Cristin, Newbury, Robert, Nhu, Quan, Oyibo, Oghenekpaobor (Joel), Paliana, Allisa, Pan, Zhaoxing, Pesek, Robbie, Peterson, Kathryn, Poppendeck, Heidi, Putnam, Philip, Rivera, Fabian, Rothenberg, Marc, Rudman-Spergel, Amanda, Sable, Kathleen, Schoepfer, Alain, Scott, Melissa, Sheridan, Rachel, Sinanovic, Selma, Spergel, Jonathan, Strobel, MaryJo, Sun, Kiki, Tasco, Amy, Tholen, Crystal, Thompson, Katherine, Tomkinson, Tiffany, Tran, Daisy, Tylicki, Alexandra, Urv, Tiina, Wang, Mei-Lun, Wechsler, Joshua, Wershil, Barry, Wheatley, Lisa, Wilkey, Leah, Yang, Guang-Yu, Zalewski, Angelika, Zicarelli, Amy, Collins, Margaret H., Rothenberg, Marc E., and Furuta, Glenn T.

Published
2020
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12. Epidemiology, Pathophysiology, and Classification of Fecal Incontinence: State of the Science Summary for the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Workshop

Author

Bharucha, Adil E, Dunivan, Gena, Goode, Patricia S, Lukacz, Emily S, Markland, Alayne D, Matthews, Catherine A, Mott, Louise, Rogers, Rebecca G, Zinsmeister, Alan R, Whitehead, William E, Rao, Satish SC, and Hamilton, Frank A

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Nutrition, Digestive Diseases, Aging, Renal and urogenital, Oral and gastrointestinal, Anal Canal, Education, Fecal Incontinence, Female, Humans, Male, National Institute of Diabetes and Digestive and Kidney Diseases (U.S.), Pelvic Floor, Prevalence, Quality of Life, Risk Factors, Severity of Illness Index, United States, Gastroenterology & Hepatology, Clinical sciences
Abstract

In August 2013, the National Institutes of Health sponsored a conference to address major gaps in our understanding of the epidemiology, pathophysiology, and management of fecal incontinence (FI) and to identify topics for future clinical research. This article is the first of a two-part summary of those proceedings. FI is a common symptom, with a prevalence that ranges from 7 to 15% in community-dwelling men and women, but it is often underreported, as providers seldom screen for FI and patients do not volunteer the symptom, even though the symptoms can have a devastating impact on the quality of life. Rough estimates suggest that FI is associated with a substantial economic burden, particularly in patients who require surgical therapy. Bowel disturbances, particularly diarrhea, the symptom of rectal urgency, and burden of chronic illness are the strongest independent risk factors for FI in the community. Smoking, obesity, and inappropriate cholecystectomy are emerging, potentially modifiable risk factors. Other risk factors for FI include advanced age, female gender, disease burden (comorbidity count, diabetes), anal sphincter trauma (obstetrical injury, prior surgery), and decreased physical activity. Neurological disorders, inflammatory bowel disease, and pelvic floor anatomical disturbances (rectal prolapse) are also associated with FI. The pathophysiological mechanisms responsible for FI include diarrhea, anal and pelvic floor weakness, reduced rectal compliance, and reduced or increased rectal sensation; many patients have multifaceted anorectal dysfunctions. The type (urge, passive or combined), etiology (anorectal disturbance, bowel symptoms, or both), and severity of FI provide the basis for classifying FI; these domains can be integrated to comprehensively characterize the symptom. Several validated scales for classifying symptom severity and its impact on the quality of life are available. Symptom severity scales should incorporate the frequency, volume, consistency, and nature (urge or passive) of stool leakage. Despite the basic understanding of FI, there are still major knowledge gaps in disease epidemiology and pathogenesis, necessitating future clinical research in FI.

Published
2015

13. Ethnic, Racial, and Sex Differences in Etiology, Symptoms, Treatment, and Symptom Outcomes of Patients With Gastroparesis

Author

Parkman, Henry P., Yamada, Goro, Van Natta, Mark L., Yates, Katherine, Hasler, William L., Sarosiek, Irene, Grover, Madhusudan, Schey, Ron, Abell, Thomas L., Koch, Kenneth L., Kuo, Braden, Clarke, John, Farrugia, Gianrico, Nguyen, Linda, Snape, William J., Miriel, Laura, Tonascia, James, Hamilton, Frank, Pasricha, Pankaj J., and McCallum, Richard W.

Published
2019
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15. Correction to: Off-label-dosing of non-vitamin K-dependent oral antagonists in AF patients before and after stroke: results of the prospective multicenter Berlin Atrial Fibrillation Registry

Author

Tütüncü, Serdar, Olma, Manuel, Kunze, Claudia, Dietzel, Joanna, Schurig, Johannes, Fiessler, Cornelia, Malsch, Carolin, Haas, Tobias Eberhard, Dimitrijeski, Boris, Doehner, Wolfram, Hagemann, Georg, Hamilton, Frank, Honermann, Martin, Jungehulsing, Gerhard Jan, Kauert, Andreas, Koennecke, Hans-Christian, Mackert, Bruno-Marcel, Nabavi, Darius, Nolte, Christian H., Reis, Joschua Mirko, Schmehl, Ingo, Sparenberg, Paul, Stingele, Robert, Völzke, Enrico, Waldschmidt, Carolin, Zeise-Wehry, Daniel, Heuschmann, Peter U., Endres, Matthias, and Haeusler, Karl Georg

Published
2022
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16. S650 Effects of COVID-19 in Patients With Gastroparesis: An Analysis of Patients in the NIH Gastroparesis Registry

Author

Parkman, Henry, primary, Yates, Katherine, additional, McCallum, Richard, additional, Koch, Kenneth, additional, Sarosiek, Irene, additional, Bulat, Robert S., additional, Abell, Thomas, additional, Kuo, Braden, additional, Malik, Zubair, additional, Farrugia, Gianrico, additional, Chumpitazi, Bruno, additional, Shulman, Robert, additional, Miriel, Laura, additional, Tonascia, James, additional, Hamilton, Frank, additional, Pasricha, Pankaj, additional, and Grover, Madhusudan, additional

Published
2023
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17. A pilot genome‐wide association study meta‐analysis of gastroparesis

Author

Tavares, Leticia Camargo, primary, Zheng, Tenghao, additional, Kwicklis, Madeline, additional, Mitchell, Emily, additional, Pandit, Anita, additional, Pullapantula, Suraj, additional, Bernard, Cheryl, additional, Teder‐Laving, Maris, additional, Marques, Francine Z., additional, Esko, Tonu, additional, Kuo, Braden, additional, Shulman, Robert J., additional, Chumpitazi, Bruno P., additional, Koch, Kenneth L., additional, Sarosiek, Irene, additional, Abell, Thomas L., additional, McCallum, Richard W., additional, Parkman, Henry P., additional, Pasricha, Pankaj J., additional, Hamilton, Frank A., additional, Tonascia, James, additional, Zawistowski, Matthew, additional, Farrugia, Gianrico, additional, Grover, Madhusudan, additional, and D’Amato, Mauro, additional

Published
2023
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20. Abdominal Pain in Patients with Gastroparesis: Associations with Gastroparesis Symptoms, Etiology of Gastroparesis, Gastric Emptying, Somatization, and Quality of Life

Author

Parkman, Henry P., Wilson, Laura A., Hasler, William L., McCallum, Richard W., Sarosiek, Irene, Koch, Kenneth L., Abell, Thomas L., Schey, Ron, Kuo, Braden, Snape, William J., Nguyen, Linda, Farrugia, Gianrico, Grover, Mandhusudan, Clarke, John, Miriel, Laura, Tonascia, James, Hamilton, Frank, and Pasricha, Pankaj J.

Published
2019
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22. Relationships among Intragastric Meal Distribution during Gastric Emptying, Water Consumption during Water Load Satiety Testing, and Symptoms of Gastroparesis

Author

Parkman, Henry P., primary, Wilson, Laura A., additional, Silver, Paul, additional, Maurer, Alan H., additional, Sarosiek, Irene, additional, Bulat, Robert S., additional, Kuo, Braden, additional, Grover, Madhusudan, additional, Farrugia, Gianrico, additional, Chumpitazi, Bruno P., additional, Shulman, Robert J., additional, Malik, Zubair, additional, Miriel, Laura A., additional, Tonascia, James, additional, Hamilton, Frank, additional, Abell, Thomas L., additional, Pasricha, Pankaj J., additional, McCallum, Richard W., additional, and Koch, Kenneth L., additional

Published
2023
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23. Relationships among intragastric meal distribution during gastric emptying scintigraphy, water consumption during water load satiety testing, and symptoms of gastroparesis.

Author

Parkman, Henry P., Wilso, Laura A., Silver, Paul, Maurer, Alan H., Sarosiek, Irene, Bulat, Robert S., Kuo, Braden, Grover, Madhusudan, Farrugia, Gianrico, Chumpitazi, Bruno P., Shulman, Robert J., Malik, Zubair, Mirie, Laura A., Tonascia, James, Hamilton, Frank, Abell, Thomas L., Pasricha, Pankaj J., McCallum, Richard W., and Koch, Kenneth L.

Subjects
GASTROPARESIS, GASTRIC emptying, WATER consumption, RADIONUCLIDE imaging, PUBLIC transit, APPETITE loss
Abstract

Gastric emptying scintigraphy (GES) measures total gastric retention after a solid meal and can assess intragastric meal distribution (IMD). Water load satiety test (WLST) measures gastric capacity. Both IMD immediately after meal ingestion [ratio of proximal gastric counts after meal ingestion to total gastric counts at time 0 (IMD0)] and WLST (volume of water ingested over 5 min) are indirect measures of gastric accommodation. In this study, IMD0 and WLST were compared with each other and to symptoms of gastroparesis to gauge their clinical utility for assessing patients with symptoms of gastroparesis. Patients with symptoms of gastroparesis underwent GES to obtain gastric retention and IMD0, WLST, and filled out patient assessment of upper GI symptoms. A total of 234 patients with symptoms of gastroparesis were assessed (86 patients with diabetes, 130 idiopathic, 18 postfundoplication) and 175 (75%) delayed gastric emptying. Low IMD0 <0.568 suggesting initial rapid transit to the distal stomach was present in 8% and correlated with lower gastric retention, less heartburn, and lower volumes consumed during WLST. Low WLST volume (<238 mL) was present in 20% and associated with increased severity of early satiety, postprandial fullness, loss of appetite, and nausea. Low IMD0 is associated with less gastric retention and less heartburn. Volume of water consumed during WLST, while associated with IMD0, has associations with early satiety, postprandial fullness, loss of appetite, and nausea. Thus, IMD0 and WLST appear to overlap somewhat in their assessment of gastric physiology in adults with symptoms of gastroparesis but relate to different dyspeptic symptoms. NEW & NOTEWORTHY IMD0 and WLST were assessed for their clinical utility in assessing patients with symptoms of gastroparesis. Low IMD0 is associated with less gastric retention and less heartburn. Volume of water consumed during WLST, while associated with IMD0, has associations with early satiety, postprandial fullness, loss of appetite, and nausea. IMD0 and WLST appear to overlap somewhat in their assessment of gastric physiology in adults with symptoms of gastroparesis but relate to different dyspeptic symptoms. [ABSTRACT FROM AUTHOR]

Published
2023
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26. Buspirone for early satiety and symptoms of gastroparesis: A multi‐centre, randomised, placebo‐controlled, double‐masked trial (BESST).

Author

Parkman, Henry P., Yates, Katherine P., Sarosiek, Irene, Bulat, Robert S., Abell, Thomas L., Koch, Kenneth L., Kuo, Braden, Grover, Madhusudan, Farrugia, Gianrico, Silver, Paul, Abdullah, Amirah, Maurer, Alan H., Malik, Zubair, Miriel, Laura A., Tonascia, James, Hamilton, Frank, Pasricha, Pankaj J., and McCallum, Richard W.

Subjects
GASTROPARESIS, BUSPIRONE, GASTRIC emptying, SYMPTOMS, PLACEBOS
Abstract

Summary: Background: Patients with gastroparesis and related disorders have symptoms including early satiety, postprandial fullness and bloating. Buspirone, a 5‐HT1 receptor agonist, may improve fundic accommodation. Aim: To determine if buspirone treatment improves early satiety and postprandial fullness in patients with symptoms of gastroparesis. Methods: This 4‐week multi‐centre clinical trial randomised patients with symptoms of gastroparesis and moderate‐to‐severe symptoms of fullness (Gastroparesis Cardinal Symptom Index [GCSI] early satiety/postprandial fullness subscore [ES/PPF]) to buspirone (10 mg orally) or placebo three times per day. The primary outcome was a change in the ES/PPF from baseline to 4 weeks. The primary analysis was per protocol intention‐to‐treat ANCOVA of between‐group baseline vs. 4‐week differences (DoD) in ES/PPF adjusted for baseline ES/PPF. Results are reported using both nominal and Bonferroni (BF) p values. Results and conclusions: Ninety‐six patients (47 buspirone, 49 placeboes; 92% female, 50% delayed gastric emptying, 39% diabetic) were enrolled. There was no between‐groups difference in the 4‐week ES/PPF primary outcome: −1.16 ± 1.25 (SD) on buspirone vs −1.03 ± 1.29 (SD) on placebo (mean DoD: −0.11 [95% CI: −0.68, 0.45]; p = 0.69). Buspirone performed better than placebo in patients with severe‐to‐very severe bloating at baseline compared to patients with none to moderate: (ES/PPF DoD = −0.65 vs. 1.58, pTX*GROUP = 0.003; pBF = 0.07). Among individual GCSI symptoms, only bloating appeared to improve with buspirone vs. placebo. Conclusions: Patients with moderate‐to‐severe early satiety/postprandial fullness and other symptoms of gastroparesis did not benefit from buspirone treatment to improve the ES/PPF primary outcome compared with placebo. There was a suggestion of the benefit of buspirone in patients with more severe bloating. Trial Registration: ClinicalTrials.gov NCT0358714285. [ABSTRACT FROM AUTHOR]

Published
2023
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27. Transcriptomic signatures reveal immune dysregulation in human diabetic and idiopathic gastroparesis

Author

Grover, Madhusudan, Gibbons, Simon J., Nair, Asha A., Bernard, Cheryl E., Zubair, Adeel S., Eisenman, Seth T., Wilson, Laura A., Miriel, Laura, Pasricha, Pankaj J., Parkman, Henry P., Sarosiek, Irene, McCallum, Richard W., Koch, Kenneth L., Abell, Thomas L., Snape, William J., Kuo, Braden, Shulman, Robert J., McKenzie, Travis J., Kellogg, Todd A., Kendrick, Michael L., Tonascia, James, Hamilton, Frank A., Farrugia, Gianrico, and the NIDDK Gastroparesis Clinical Research Consortium (GpCRC)

Published
2018
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28. Postprandial symptoms in patients with symptoms of gastroparesis: roles of gastric emptying and accommodation

Author

Parkman, Henry P., primary, Van Natta, Mark L., additional, Maurer, Alan H., additional, Koch, Kenneth L., additional, Grover, Madhusudan, additional, Malik, Zubair, additional, Sarosiek, Irene, additional, Abell, Thomas L., additional, Bulat, Robert, additional, Kuo, Braden, additional, Shulman, Robert J., additional, Farrugia, Gianrico, additional, Miriel, Laura, additional, Tonascia, James, additional, Hamilton, Frank, additional, Pasricha, Pankaj J., additional, and McCallum, Richard W., additional

Published
2022
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29. Characteristics and outcomes of patients with gastroparesis using enteral and/or exclusive parenteral nutrition.

Author

Parkman, Henry P., Blackford, Amanda L., Murray, Helen Burton, Yates, Katherine P., Grover, Madhusudan, Malik, Zubair, Schey, Ron, Bulat, Robert S., Koch, Kenneth L., Sarosiek, Irene, Kuo, Braden, Shulman, Robert J., Chumpitazi, Bruno P., Farrugia, Gianrico, Miriel, Laura, Tonascia, James, Hamilton, Frank, Pasricha, Pankaj J., McCallum, Richard W., and Abell, Thomas L.

Subjects
GASTRIC emptying, PARENTERAL feeding, GASTROPARESIS, BODY mass index, ENTERAL feeding
Abstract

Background: Patients with gastroparesis (Gp) may need enteral nutrition (EN) or exclusive parenteral nutrition (PN). Among patients with Gp, we aimed to (1) identify the frequency of EN and exclusive PN use and (2) explore characteristics of patients using EN and/or exclusive PN compared with those using oral nutrition (ON), including changes over 48 weeks. Methods: Patients with Gp underwent history and physical examination, gastric emptying scintigraphy, water load satiety testing (WLST), and questionnaires assessing gastrointestinal symptoms and quality of life (QOL). Patients were observed 48 weeks. Results: Of 971 patients with Gp (idiopathic, 579; diabetic, 336; post–Nissen fundoplication, 51), 939 (96.7%) were using ON only, 14 (1.4%) using exclusive PN, and 18 (1.9%) using EN. Compared with patients receiving ON, patients receiving exclusive PN and/or EN were younger, had lower body mass index, and had greater symptom severity. Patients receiving exclusive PN and/or EN had lower physical QOL but not mental QOL or Gp‐related QOL scores. Patients receiving exclusive PN and/or EN ingested less water during WLST but did not have worse gastric emptying. Of those who had been receiving exclusive PN and/or EN, 50% and 25%, respectively, resumed ON at 48‐week follow‐up. Conclusions: This study describes patients with Gp requiring exclusive PN and/or EN for nutrition support, who represent a small (3.3%) but important subset of patients with Gp. Unique clinical and physiological parameters are associated with this subset and provide insight into the use of nutrition support in Gp. [ABSTRACT FROM AUTHOR]

Published
2023
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31. 646: GENOME-WIDE ASSOCIATION META-ANALYSIS OF GASTROPARESIS

Author

Tavares, Leticia C., primary, Zheng, Tenghao, additional, Mitchell, Emily P., additional, Kwicklis, Madeline, additional, Pandit, Anita, additional, Bernard, Cheryl, additional, Teder-Laving, Maris, additional, Marques, Francine, additional, Esko, Tonu, additional, Zawistowski, Matthew, additional, Kuo, Braden, additional, Shulman, Robert J., additional, Chumpitazi, Bruno P., additional, Koch, Kenneth L., additional, Sarosiek, Irene, additional, Abell, Thomas, additional, McCallum, Richard W., additional, Parkman, Henry P., additional, Pasricha, Pankaj J., additional, Hamilton, Frank A., additional, Tonascia, James, additional, Farrugia, Gianrico, additional, Grover, Madhusudan, additional, and D'Amato, Mauro, additional

Published
2022
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32. 1073: A SINGLE-CELL SURVEY OF GASTRIC MUSCULARIS MACROPHAGES IN DIABETIC GASTROPARESIS

Author

Wei, Lai, primary, Jessen, Erik, additional, Bernard, Cheryl, additional, Chikkamenahalli, Lakshmikanth, additional, Breen-Lyles, Margaret K., additional, Ghanem, Omar, additional, Mckenzie, Travis J., additional, Yates, Katherine P., additional, Kuo, Braden, additional, Shulman, Robert J., additional, Chumpitazi, Bruno P., additional, Koch, Kenneth L., additional, Sarosiek, Irene, additional, Abell, Thomas, additional, McCallum, Richard W., additional, Parkman, Henry P., additional, Pasricha, Pankaj J., additional, Hamilton, Frank A., additional, Tonascia, James, additional, Farrugia, Gianrico, additional, Dasari, Surendra, additional, and Grover, Madhusudan, additional

Published
2022
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33. 1155: PATIENTS WITH GASTROPARESIS USING ENTERAL AND/OR PARENTERAL NUTRITION: CLINICAL CHARACTERISTICS AND CLINICAL OUTCOME.

Author

Parkman, Henry P., primary, Blackford, Amanda L., additional, Yates, Katherine P., additional, Grover, Madhusudan, additional, Malik, Zubair A., additional, Schey, Ron, additional, Bulat, Robert S., additional, Koch, Kenneth L., additional, Sarosiek, Irene, additional, Kuo, Braden, additional, Shulman, Robert J., additional, Farrugia, Gianrico, additional, Miriel, Laura A., additional, Tonascia, James, additional, Hamilton, Frank A., additional, Pasricha, Pankaj J., additional, McCallum, Richard W., additional, and Abell, Thomas, additional

Published
2022
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35. 1074: QUANTITATIVE SENSORY TESTING OF ABDOMINAL PAIN RESPONSES: CLINICAL RELEVANCE OF PAIN SENSITIVITY IN GASTROPARESIS

Author

Murray, Helen Burton, primary, Mitchell, Emily P., additional, Edwards, Robert, additional, McCallum, Richard W., additional, Sarosiek, Irene, additional, Koch, Kenneth L., additional, Grover, Madhusudan, additional, Farrugia, Gianrico, additional, Parkman, Henry P., additional, Tonascia, James, additional, Shulman, Robert J., additional, Hamilton, Frank A., additional, Abell, Thomas, additional, Pasricha, Pankaj J., additional, and Kuo, Braden, additional

Published
2022
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36. Evaluating Eosinophilic Colitis as a Unique Disease Using Colonic Molecular Profiles: A Multi-Site Study

Author

Shoda, Tetsuo, primary, Collins, Margaret H., additional, Rochman, Mark, additional, Wen, Ting, additional, Caldwell, Julie M., additional, Mack, Lydia E., additional, Osswald, Garrett A., additional, Besse, John A., additional, Haberman, Yael, additional, Aceves, Seema S., additional, Arva, Nicoleta C., additional, Capocelli, Kelley E., additional, Chehade, Mirna, additional, Davis, Carla M., additional, Dellon, Evan S., additional, Falk, Gary W., additional, Gonsalves, Nirmala, additional, Gupta, Sandeep K., additional, Hirano, Ikuo, additional, Khoury, Paneez, additional, Klion, Amy, additional, Menard-Katcher, Calies, additional, Leung, John, additional, Mukkada, Vincent A., additional, Putnam, Philip E., additional, Spergel, Jonathan M., additional, Wechsler, Joshua B., additional, Yang, Guang-Yu, additional, Furuta, Glenn T., additional, Denson, Lee A., additional, Rothenberg, Marc E., additional, Pablo Abonia, J., additional, Aceves, Seema, additional, Almonte, Samuel, additional, Andrews, Rachel, additional, Anvari, Sara, additional, Arrington, Ashley, additional, Arva, Nicoleta, additional, Atkins, Fred, additional, Bailey, Dominique, additional, Berry, Alexis, additional, Besl, Bridget, additional, Bolton, Scott, additional, Bonis, Peter, additional, Book, Wendy, additional, Bray, Kimberly, additional, Brown, Teresa, additional, Burger, Cassandra, additional, Burke, Deirdre, additional, Cahoon, Jonathon, additional, Capocelli, Kelley, additional, Chiou, Eric, additional, Collins, Margaret, additional, Davis, Carla, additional, Dellon, Evan, additional, DeMarshall, Maureen, additional, DiTommaso, Lauren, additional, Dohil, Ranjan, additional, Eby, Michael, additional, Falk, Gary, additional, Fleischer, David, additional, Foote, Heather, additional, Foss, Kelci, additional, Friedlander, Joel, additional, Fulkerson, Patricia, additional, Furuta, Glenn, additional, Geno, Debra, additional, Greuter, Thomas, additional, Gupta, Sandeep, additional, Hamilton, Frank, additional, Harris, Kirk, additional, Harris, Jennifer, additional, Hiremath, Girish, additional, Holland-Thomas, Nicole, additional, Jacinto, Lea, additional, Kagalwalla, Amir, additional, Kaseta, Timothy, additional, Katzka, David, additional, Keeley, Kaitlin, additional, Khosh-Hemmat, Emad, additional, King, Eileen, additional, Kliewer, Kara, additional, Knowles, Jennifer, additional, Kocher, Kendra, additional, Kodroff, Ellyn, additional, Krischer, Jeffrey, additional, Kyle, Shay, additional, Levy, Meredith, additional, Liacouras, Chris, additional, Mack, Denise, additional, Martin, Lisa, additional, Martin, Ellen, additional, McCright-Gill, Talaya, additional, Menard-Katcher, Paul, additional, Mendoza, Gabriela, additional, Mingler, Melissa, additional, Minnicozzi, Mike, additional, Muir, Amanda, additional, Mukkada, Vincent, additional, Murray-Petzold, Cristin, additional, Newbury, Robert, additional, Nhu, Quan, additional, Olive, Anthony, additional, Oyibo, Oghenekpaobor (Joel), additional, Paliana, Allisa, additional, Pan, Zhaoxing, additional, Pesek, Robbie, additional, Peterson, Kathryn, additional, Poppendeck, Heidi, additional, Putnam, Philip, additional, Rivera, Fabian, additional, Rothenberg, Marc, additional, Spergel, Amanda Rudman, additional, Sable, Kathleen, additional, Schoepfer, Alain, additional, Scott, Melissa, additional, Sheridan, Rachel, additional, Sinanovic, Selma, additional, Spergel, Jonathan, additional, Strobel, Mary Jo, additional, Sun, Kiki, additional, Tasco, Amy, additional, Tholen, Crystal, additional, Thompson, Katherine, additional, Tomkinson, Tiffany, additional, Tran, Daisy, additional, Tylicki, Alexandra, additional, Urv, Tiina, additional, Wang, Mei-Lun, additional, Wechsler, Joshua, additional, Wershil, Barry, additional, Wheatley, Lisa, additional, Wilkey, Leah, additional, Zalewski, Angelika, additional, and Zicarelli, Amy, additional

Published
2022
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40. Loss of Endothelial TSPAN12 Promotes Fibrostenotic Eosinophilic Esophagitis via Endothelial Cell–Fibroblast Crosstalk

Author

Shoda, Tetsuo, primary, Wen, Ting, additional, Caldwell, Julie M., additional, Ben-Baruch Morgenstern, Netali, additional, Osswald, Garrett A., additional, Rochman, Mark, additional, Mack, Lydia E., additional, Felton, Jennifer M., additional, Abonia, J. Pablo, additional, Arva, Nicoleta C., additional, Atkins, Dan, additional, Bonis, Peter A., additional, Capocelli, Kelley E., additional, Collins, Margaret H., additional, Dellon, Evan S., additional, Falk, Gary W., additional, Gonsalves, Nirmala, additional, Gupta, Sandeep K., additional, Hirano, Ikuo, additional, Leung, John, additional, Menard-Katcher, Paul A., additional, Mukkada, Vincent A., additional, Putnam, Philip E., additional, Rudman Spergel, Amanda K., additional, Spergel, Jonathan M., additional, Wechsler, Joshua B., additional, Yang, Guang-Yu, additional, Aceves, Seema S., additional, Furuta, Glenn T., additional, Rothenberg, Marc E., additional, Aceves, Seema, additional, Almonte, Samuel, additional, Andrews, Rachel, additional, Arrington, Ashley, additional, Arva, Nicoleta, additional, Atkins, Fred, additional, Bailey, Dominique, additional, Berry, Alexis, additional, Besl, Bridget, additional, Bolton, Scott, additional, Bonis, Peter, additional, Book, Wendy, additional, Bray, Kimberly, additional, Brown, Teresa, additional, Burger, Cassandra, additional, Burke, Deirdre, additional, Cahoon, Jonathon, additional, Capocelli, Kelley, additional, Chehade, Mirna, additional, Collins, Margaret, additional, Davis, Carla, additional, Dellon, Evan, additional, DeMarshall, Maureen, additional, DiTommaso, Lauren, additional, Dohil, Ranjan, additional, Eby, Michael, additional, Falk, Gary, additional, Fleischer, David, additional, Foote, Heather, additional, Foss, Kelci, additional, Friedlander, Joel, additional, Fulkerson, Patricia, additional, Furuta, Glenn, additional, Geno, Debra, additional, Greuter, Thomas, additional, Gupta, Sandeep, additional, Hamilton, Frank, additional, Harris, Kirk, additional, Harris, Jennifer, additional, Hiremath, Girish, additional, Holland-Thomas, Nicole, additional, Jacinto, Lea, additional, Kagalwalla, Amir, additional, Kaseta, Timothy, additional, Katzka, David, additional, Keeley, Kaitlin, additional, Khosh-Hemmat, Emad, additional, Khoury, Paneez, additional, King, Eileen, additional, Kliewer, Kara, additional, Klion, Amy, additional, Knowles, Jennifer, additional, Kocher, Kendra, additional, Kodroff, Ellyn, additional, Krischer, Jeffrey, additional, Kyle, Shay, additional, Levy, Meredith, additional, Liacouras, Chris, additional, Mack, Denise, additional, Martin, Lisa, additional, Martin, Ellen, additional, McCright-Gill, Talaya, additional, Menard-Katcher, Paul, additional, Menard-Katcher, Calies, additional, Mendoza, Gabriela, additional, Mingler, Melissa, additional, Minnicozzi, Mike, additional, Muir, Amanda, additional, Mukkada, Vincent, additional, MurrayPetzold, Cristin, additional, Newbury, Robert, additional, Nhu, Quan, additional, Oyibo, Oghenekpaobor (Joel), additional, Paliana, Allisa, additional, Pan, Zhaoxing, additional, Pesek, Robbie, additional, Peterson, Kathryn, additional, Poppendeck, Heidi, additional, Putnam, Philip, additional, Rivera, Fabian, additional, Rothenberg, Marc, additional, Spergel, Amanda Rudman, additional, Sable, Kathleen, additional, Schoepfer, Alain, additional, Scott, Melissa, additional, Sheridan, Rachel, additional, Sinanovic, Selma, additional, Spergel, Jonathan, additional, Strobel, MaryJo, additional, Sun, Kiki, additional, Tasco, Amy, additional, Tholen, Crystal, additional, Thompson, Katherine, additional, Tomkinson, Tiffany, additional, Tran, Daisy, additional, Tylicki, Alexandra, additional, Urv, Tiina, additional, Wang, Mei-Lun, additional, Wechsler, Joshua, additional, Wershil, Barry, additional, Wheatley, Lisa, additional, Wilkey, Leah, additional, Zalewski, Angelika, additional, and Zicarelli, Amy, additional

Published
2022
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41. Problems and Answers for School Busing.

Author

Hamilton, Frank A.

Abstract

The New Paltz, New York, school district has used the IBM Vehicle Scheduling Program (VSP) for scheduling its bus runs. In the process the district has reduced its transportation costs by 33.9 percent over a two-year period. (IRT)

Published
1976

43. Effect of liquid and solid test meals on symptoms and gastric myoelectrical activity in patients with gastroparesis and functional dyspepsia.

Author

Koch, Kenneth L., Van Natta, Mark, Parkman, Henry P., Grover, Madhusudan, Abell, Thomas L., McCallum, Richard W., Shaltout, Hossam A., Sarosiek, Irene, Farrugia, Gianrico, Shulman, Robert J., Tonascia, James, Miriel, Laura, Hamilton, Frank, and Pasricha, Pankaj J.

Subjects
GASTROPARESIS, INDIGESTION, NEUROMUSCULAR diseases, ABDOMINAL pain, VISUAL analog scale, SYMPTOMS
Abstract

Background: Patients with gastroparesis (GP) and functional dyspepsia (FD) have similar symptoms, but the pathophysiology of postprandial symptoms remains uncertain. Aims: To compare symptoms and gastric myoelectrical activity (GMA) after liquid and solid test meals in patients with GP and FD. Methods: Patients enrolled in the Gastroparesis Clinical Research Consortium Registry were studied. Clinical characteristics were measured with standard questionnaires. GP was determined by 4‐h solid‐phase gastric scintigraphy. GMA was measured using electrogastrography before and after ingestion of a water load or nutrient bar on separate days. Symptoms were measured on visual analog scales. GMA responses to the water load for individual patients were also determined. Results: 284 patients with GP and 113 with FD were identified who ingested both test meals. Patients with GP and FD had similar maximal tolerated volumes of water [mean (SD) 378 (218) ml vs. 402 (226) ml, p = 0.23] and reported similar intensity of fullness, nausea, bloating, and abdominal discomfort after the test meals. Twenty‐six percent and 19% of the patients with GP and FD, respectively, ingested subthreshold (<238 ml) volumes of water (p = 0.15). Gastric dysrhythmias were recorded in 66% of the GP and 65% of the FD patients after the water load. Symptoms and GMA were similar in both groups after ingestion of the nutrient bar. Conclusion: The similarity in GMA responses and symptoms after ingestion of solid or liquid test meals suggests GP and FD are closely related gastric neuromuscular disorders. [ABSTRACT FROM AUTHOR]

Published
2023
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44. Case Study

Author

Alekseiev, Sergii, primary, Harris, Ambria, additional, Rylander, Edward, additional, Hamilton, Frank, additional, Winters-Miner, Linda A., additional, and Miner, Gary D., additional

Published
2015
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45. Guest Tutorial Authors

Author

Alekseiev, Sergii, primary, Amer, Magid, additional, Armentrout, David P., additional, Barancik, Elizabeth, additional, Cook, Michael, additional, Cromwell, John W., additional, Darrell, Kenny, additional, Farrar, Christopher D., additional, Hamilton, Frank, additional, Harris, Ambria, additional, Howell, Welling, additional, Jakubowski, Jacek, additional, Lee, Amy Junghyun, additional, Khichi, Mahmood H., additional, Kusy, Michał, additional, Majumdar, Samrat, additional, Miller, Ronald Mellado, additional, Meyers, John E., additional, Migutb, Grzegorz, additional, Moncada, Stephanie, additional, Parsons, Wanda P., additional, Peele, Pamela, additional, Petitt, Steve, additional, Rastunkov, Vladimir, additional, Redfearn, David, additional, Rupp, Zachary W., additional, Rylander, Edward, additional, Smith, Brian J., additional, Stout, Danny W., additional, Varanasi, Haranath, additional, Wagner, Matthew, additional, Wang, Chamont, additional, Wang, Charlene, additional, Winters, Ralph, additional, Yale, Ken, additional, and Zasadil, Scott, additional

Published
2015
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46. Correction to: Off-label-dosing of non-vitamin K-dependent oral antagonists in AF patients before and after stroke: results of the prospective multicenter Berlin Atrial Fibrillation Registry

Author

Tütüncü, Serdar, primary, Olma, Manuel, additional, Kunze, Claudia, additional, Dietzel, Joanna, additional, Schurig, Johannes, additional, Fiessler, Cornelia, additional, Malsch, Carolin, additional, Haas, Tobias Eberhard, additional, Dimitrijeski, Boris, additional, Doehner, Wolfram, additional, Hagemann, Georg, additional, Hamilton, Frank, additional, Honermann, Martin, additional, Jungehulsing, Gerhard Jan, additional, Kauert, Andreas, additional, Koennecke, Hans-Christian, additional, Mackert, Bruno-Marcel, additional, Nabavi, Darius, additional, Nolte, Christian H., additional, Reis, Joschua Mirko, additional, Schmehl, Ingo, additional, Sparenberg, Paul, additional, Stingele, Robert, additional, Völzke, Enrico, additional, Waldschmidt, Carolin, additional, Zeise-Wehry, Daniel, additional, Heuschmann, Peter U., additional, Endres, Matthias, additional, and Haeusler, Karl Georg, additional

Published
2021
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47. Off-label-dosing of non-vitamin K-dependent oral antagonists in AF patients before and after stroke: results of the prospective multicenter Berlin Atrial Fibrillation Registry

Author

Tütüncü, Serdar, primary, Olma, Manuel, additional, Kunze, Claudia, additional, Dietzel, Joanna, additional, Schurig, Johannes, additional, Fiessler, Cornelia, additional, Malsch, Carolin, additional, Haas, Tobias Eberhard, additional, Dimitrijeski, Boris, additional, Doehner, Wolfram, additional, Hagemann, Georg, additional, Hamilton, Frank, additional, Honermann, Martin, additional, Jungehulsing, Gerhard Jan, additional, Kauert, Andreas, additional, Koennecke, Hans-Christian, additional, Mackert, Bruno-Marcel, additional, Nabavi, Darius, additional, Nolte, Christian H., additional, Reis, Joschua Mirko, additional, Schmehl, Ingo, additional, Sparenberg, Paul, additional, Stingele, Robert, additional, Völzke, Enrico, additional, Waldschmidt, Carolin, additional, Zeise-Wehry, Daniel, additional, Heuschmann, Peter U., additional, Endress, Matthias, additional, and Haeusler, Karl Georg, additional

Published
2021
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48. Cholecystectomy and Clinical Presentations of Gastroparesis

Author

Parkman, Henry P., Yates, Katherine, Hasler, William L., Nguyen, Linda, Pasricha, Pankaj J., Snape, William J., Farrugia, Gianrico, Koch, Kenneth L., Calles, Jorge, Abell, Thomas L., Sarosiek, Irene, McCallum, Richard W., Lee, Linda, Unalp-Arida, Aynur, Tonascia, James, and Hamilton, Frank

Published
2013
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