20 results on '"Hamida, Al Hussein"'
Search Results
2. Evaluation of Perioperative Beta-Blockers and Factors Associated with Postoperative Atrial Fibrillation in Cardiac Surgery: A Single Center Experience
- Author
-
Alexandra Puscas, Marius M. Harpa, Klara Brinzaniuc, Hussam Al-Hussein, Hamida Al-Hussein, Cosmin Banceu, Carmen Opris, Claudiu Ghiragosian, Sanziana Flamind, Robert Balan, Septimiu Voidazan, and Horatiu Suciu
- Subjects
postoperative atrial fibrillation ,supraventricular arrhythmia ,cardiac surgery ,beta-blocker ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background: Postoperative atrial fibrillation (AF) has a complex etiology, and beta-blockers are commonly recommended for its pharmacological prevention. This study aims to assess the impact of beta-blocker therapy on postoperative AF occurrence in patients undergoing aortic valve replacement, mitral valve replacement, surgical revascularization of the myocardium, or a combination of these procedures. Methods: The study encompassed 472 patients who received aortic valve replacement, mitral valve replacement, surgical revascularization, or their combination. We evaluated the efficacy of preoperative and one-month postoperative beta-blocker administration in preventing postoperative AF, and the associated risk factors involved in the development of postoperative AF. Results: Of the total patient population, 36% experienced postoperative AF. Our study demonstrated a significant reduction in postoperative AF incidence among patients receiving beta-blocker treatment (all p-values < 0.05). Additionally, one-month post-surgery, beta-blocker treatment exerted a protective effect by maintaining the sinus rhythm (p = 0.0001). Regarding the risk factors involved in the development of postoperative AF, both age and left atrium (LA) sizeassessed pre-and postoperatively—were positively correlated with the occurrence of postoperative AF (p = 0.006). No relationship was found between leukocyte counts and AF incidence. Notably, C-reactive protein (CRP) levels were significantly elevated on the fifth postoperative day in patients with AF (p < 0.007). The duration of ischemia was significantly longer in patients with AF (p = 0.009). Conclusions: This study establishes the efficacy of perioperative beta-blocker treatment in mitigating postoperative AF. One month post-surgery, most patients under beta-blocker therapy maintained sinus rhythm, suggesting a potential long-term protective effect of beta-blockers against late-onset AF.
- Published
- 2023
- Full Text
- View/download PDF
3. Developing the Tissue Engineered Heart Valve – a Descriptive Hemodynamic and Ultrasound in Vitro Characterization Study of Heart Valves in a Bioreactor
- Author
-
Ionela MOVILEANU, Dan Octavian NISTOR, Leslie SIERAD, Klara BRINZANIUC, Codrut OPRITA, Marius Mihai HARPA, Terezia PREDA, Ovidiu COTOI, Hussam AL HUSSEIN, Hamida AL HUSSEIN, Alexandru CHERTES, Horatiu SUCIU, Agneta SIMIONESCU, and Dan SIMIONESCU
- Subjects
tissue engineered heart valve ,heart valve bioreactor ,in vitro ultrasound ,regenerative medicine ,heart valve substitute ,Internal medicine ,RC31-1245 - Abstract
The inherent limitations of current heart valve substitutes create the premise for the Tissue Engineered Heart Valve (TEHV), considered the perfect substitute. We aimed to compare in vitro hemodynamic performances of our TEHV, the conventional prosthetic valve and similar porcine valves, by ultrasonography and geometry resulting in six valve models analysis. In a bioreactor, pulmonary and aortic physiology were replicated thus hemodynamic characteristics were tested. Using ultrasound, transvalvular pressure gradients and flow were measured and used to calculate their valvular functional area (VFA) and using a high-speed camera, the geometric peak opening area (GOA) was assessed. The obtained results were normalized to the diameter of the biological prosthesis in order to increase the measurement’s accuracy. The ultrasound revealed normal function of all valves and physiologic transvalvular pressure gradients. The TEHV scaffold revealed absence of laceration or dehiscence, and performances in accordance with the control prostheses. The GOA was facile to obtain and the normalized values proved to be greater than the calculated functional area in all analyzed cases and the peak opening areas resulted lesser for the aortic conditions for all six used valves prototypes. To our knowledge, this is the first study to use bioreactors, for in vitro evaluation of heart valves.
- Published
- 2021
- Full Text
- View/download PDF
4. Preclinical Testing of Living Tissue-Engineered Heart Valves for Pediatric Patients, Challenges and Opportunities
- Author
-
Ionela Movileanu, Marius Harpa, Hussam Al Hussein, Lucian Harceaga, Alexandru Chertes, Hamida Al Hussein, Georg Lutter, Thomas Puehler, Terezia Preda, Carmen Sircuta, Ovidiu Cotoi, Dan Nistor, Adrian Man, Bogdan Cordos, Radu Deac, Horatiu Suciu, Klara Brinzaniuc, Megan Casco, Leslie Sierad, Margarita Bruce, Dan Simionescu, and Agneta Simionescu
- Subjects
acellular scaffolds ,autologous cells ,bioreactor conditioning ,orthotopic implantation ,cell seeding ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Introduction: Pediatric patients with cardiac congenital diseases require heart valve implants that can grow with their natural somatic increase in size. Current artificial valves perform poorly in children and cannot grow; thus, living-tissue-engineered valves capable of sustaining matrix homeostasis could overcome the current drawbacks of artificial prostheses and minimize the need for repeat surgeries.Materials and Methods: To prepare living-tissue-engineered valves, we produced completely acellular ovine pulmonary valves by perfusion. We then collected autologous adipose tissue, isolated stem cells, and differentiated them into fibroblasts and separately into endothelial cells. We seeded the fibroblasts in the cusp interstitium and onto the root adventitia and the endothelial cells inside the lumen, conditioned the living valves in dedicated pulmonary heart valve bioreactors, and pursued orthotopic implantation of autologous cell-seeded valves with 6 months follow-up. Unseeded valves served as controls.Results: Perfusion decellularization yielded acellular pulmonary valves that were stable, no degradable in vivo, cell friendly and biocompatible, had excellent hemodynamics, were not immunogenic or inflammatory, non thrombogenic, did not calcify in juvenile sheep, and served as substrates for cell repopulation. Autologous adipose-derived stem cells were easy to isolate and differentiate into fibroblasts and endothelial-like cells. Cell-seeded valves exhibited preserved viability after progressive bioreactor conditioning and functioned well in vivo for 6 months. At explantation, the implants and anastomoses were intact, and the valve root was well integrated into host tissues; valve leaflets were unchanged in size, non fibrotic, supple, and functional. Numerous cells positive for a-smooth muscle cell actin were found mostly in the sinus, base, and the fibrosa of the leaflets, and most surfaces were covered by endothelial cells, indicating a strong potential for repopulation of the scaffold.Conclusions: Tissue-engineered living valves can be generated in vitro using the approach described here. The technology is not trivial and can provide numerous challenges and opportunities, which are discussed in detail in this paper. Overall, we concluded that cell seeding did not negatively affect tissue-engineered heart valve (TEHV) performance as they exhibited as good hemodynamic performance as acellular valves in this model. Further understanding of cell fate after implantation and the timeline of repopulation of acellular scaffolds will help us evaluate the translational potential of this technology.
- Published
- 2021
- Full Text
- View/download PDF
5. A Rare Case of Undifferentiated Pleomorphic Cardiac Sarcoma with Inflammatory Pattern
- Author
-
Alexandra Iulia Stoica, Marius Mihai Harpa, Cosmin Marian Banceu, Claudiu Ghiragosian, Carmen Elena Opris, Hussam Al-Hussein, Hamida Al-Hussein, Sanziana Flamind Oltean, Tibor Mezei, Razvan Gheorghita Mares, and Horatiu Suciu
- Subjects
cardiac tumors ,undifferentiated pleomorphic sarcoma ,cardiac surgery ,cardiac malignancy ,inflammatory response ,Medicine (General) ,R5-920 - Abstract
Cardiac undifferentiated pleomorphic sarcoma (UPS) associated with fever and inflammatory response is an extremely rare condition. Herein, we report a rare case of cardiac UPS with unusual clinical presentation and inflammatory response. A 67-year-old male complaining of progressive dyspnea and intermittent fever of unknown cause was referred to our hospital for surgical resection of a left atrial mass. Laboratory analysis showed leukocytosis (26 × 103/μL) and high C-reactive protein (CRP) levels (155.4 mg/L). Hemoculture tests and urine analysis were negative for infection. A contrast chest computed tomography revealed a mass measuring 5.5 × 4.5 cm, occupying the left atrium cavity. The patient underwent surgical excision of the mass, however, surgical margin of the resected tumor could not be evaluated, due to the multifragmented nature of the resection specimen. Postoperative CRP and leukocyte levels normalized, highlighting the relationship between the tumor and the inflammatory status. Early diagnosis is crucial for a proper management and favorable outcome, enabling patients to undergo chemotherapy and achieve complete surgical resection.
- Published
- 2022
- Full Text
- View/download PDF
6. Different Manifestations in Familial Isolated Left Ventricular Non-compaction: Two Case Reports and Literature Review
- Author
-
Hamida Al Hussein, Hussam Al Hussein, Valentin Stroe, Marius Harpa, Claudiu Ghiragosian, Cristina Maria Goia, Carmen Elena Opris, and Horatiu Suciu
- Subjects
left ventricular non-compaction ,familial ,dilated cardiomyopathy ,heart transplantation ,peripartum cardiomyopathy ,ventricular tachycardia ,Pediatrics ,RJ1-570 - Abstract
Left ventricular non-compaction (LVNC) is a form of cardiomyopathy characterized by prominent trabeculae and deep intertrabecular recesses which form a distinct “non-compacted” layer in the myocardium. It results from intrauterine arrest of the compaction process of the left ventricular myocardium. Clinical manifestations vary from asymptomatic to heart failure (HF), arrhythmias, or thromboembolic events. We present a case of mother and son diagnosed with isolated LVNC (ILVNC). A 4-years-old male patient, diagnosed at 3 months with ILVNC, and NYHA functional class IV HF, was admitted to the Emergency Institute for Cardiovascular Diseases and Transplantation of Targu Mures, Romania, for cardiologic reevaluation, and diagnosis confirmation. ILVNC was confirmed using echocardiography, revealing a non-compaction to compaction (NC/C) ratio of > 2.7. His evolution was stationary until the age of 8 years, when severe pneumonia caused hemodynamic decompensation, and he was listed for heart transplantation (HT). The patient underwent HT at the age of 11 years with favorable postoperative outcome. Meanwhile, a 22-years-old female patient, mother of the aforementioned patient, was also admitted to our institute due to severe fatigue, dyspnea, and recurrent palpitations with multiple implantable cardioverter defibrillator (ICD) shock delivery. Extensive medical history revealed that a presumptive ILVNC diagnosis was established when she was 11 years old. She was asymptomatic until 18 years old, when 3 months post-partum, she developed NYHA functional class III HF, and subsequently underwent ICD implantation. Her diagnosis was confirmed using multi-detector computed tomography angiography, which revealed a NC/C ratio of > 3.3. ICD adjustments were carried out with a favorable evolution under chronic drug therapy. The last evaluation, at 27 years old, revealed that she was in NYHA functional class II HF. In conclusion, ILVNC, even when familial, can present different clinical pictures and therefore requires different medical approaches.
- Published
- 2020
- Full Text
- View/download PDF
7. RAF-1 Mutation Associated with a Risk for Ventricular Arrhythmias in a Child with Noonan Syndrome and Cardiovascular Pathology
- Author
-
Amalia, Făgărășan, Hamida, Al Hussein, and Simina Elena, Ghiragosian Rusu
- Subjects
General Medicine - Abstract
Introduction Noonan syndrome (NS) is a dominant autosomal disease, caused by mutations in genes involved in cell differentiation, growth and senescence, one of them being RAF1 mutation. Congenital heart disease may influence the prognosis of the disease. Case presentation We report a case of an 18 month-old female patient who presented to our institute at the age of 2 months when she was diagnosed with obstructive hypertrophic cardiomyopathy, pulmonary infundibular and pulmonary valve stenosis, a small atrial septal defect and extrasystolic arrhythmia. She was born from healthy parents, a non-consanguineous marriage. Due to suggestive phenotype for NS molecular genetic testing for RASopathies was performed in a center abroad, establishing the presence of RAF-1 mutation. Following rapid progression of cardiac abnormalities, the surgical correction was performed at 14 months of age. In the early postoperative period, the patient developed episodes of sustained ventricular tachycardia with hemodynamic instability, for which associated treatment was instituted with successful conversion to sinus rhythm. At 3-month follow-up, the patient was hemodynamically stable in sinus rhythm. Conclusions The presented case report certifies the importance of recognizing the genetic mutation in patients with NS, which allows predicting the severity of cardiac abnormalities and therefore establishing a proper therapeutic management of these patients.
- Published
- 2022
8. Decompensated Aortic Stenosis in a Young Patient with Multiple Comorbidities - A Case Report
- Author
-
Alexandra Stoica, Marius Harpa, Hussam Al Hussein, Carmen Opriş, Cosmin Opriş, Hamida Al Hussein, Claudiu Ghiragosian, Cosmin Banceu, and Horaţiu Suciu
- Subjects
0301 basic medicine ,medicine.medical_specialty ,business.industry ,General Medicine ,030204 cardiovascular system & hematology ,medicine.disease ,03 medical and health sciences ,Stenosis ,030104 developmental biology ,0302 clinical medicine ,Internal medicine ,cardiovascular system ,medicine ,Cardiology ,business - Abstract
Aortic valve replacement is a safe therapy that can reverse cardiac remodeling and increase cardiac contractility, improve symptoms and quality of life. We presented a case of a 35-year-old male patient admitted to the Emergency Institute for Cardiovascular Disease and Transplantation of Târgu Mureș, Romania, due to severe aortic stenosis with severely depressed ejection fraction, left atrial myxome and a history of deep vein thrombosis and pulmonary thromboembolism. He underwent excision of the aortic valve and replacement with a mechanical prosthesis, excision of left atrial myxoma and tricuspid annuloplasty. The postoperative evolution was favourable with a significant recovery of the left ventricular systolic function and regression of cardiac symptomatology. This case was particular due to the rapid progression of the aortic pathology with the reduction of cardiac (systolic) function in a relatively short time as well as the occurrence of the thromboembolic event unrelated to the left atrial myxoma and rather associated with the background of cardiac failure with low cardiac output.
- Published
- 2020
9. Subcoronary Technique for Orthotopic Implantation of Aortic Scaffold Reinforced with Polytetrafluoroethylene Strips in Sheep: A pilot Study
- Author
-
Hussam Al Hussein, Hamida Al Hussein, Marius Harpa, Carmen Sircuta, Ovidiu S. Cotoi, Adrian Man, Radu Deac, Horatiu Suciu, Klara Brinzaniuc, and Dan Simionescu
- Subjects
Scaffold ,chemistry.chemical_compound ,Materials science ,Polytetrafluoroethylene ,Polymers and Plastics ,chemistry ,Mechanics of Materials ,Materials Chemistry ,General Chemistry ,Biomedical engineering - Abstract
Over the time, numerous studies have been reported describing successful pulmonary valve replacement, either with xenografts or allografts, performed in sheep model. In contrast, comparable results have not been achieved yet for aortic valve replacement in orthotopic position, which involves a more difficult surgical technique, high hemodynamic demands for the implanted valve and poor survival of animals undergoing this kind of surgery. To our knowledge, in Romania, these were the first orthotopic allogeneic aortic root implantations using the subcoronary technique, carried out by our team. We established feasible perioperative, anesthetic and surgical protocols, which will be used in future studies to evaluate the in vivo functional performances of decellularized valves compared with autologous adipose derived stem cells seeded valves. Therefore, a unique research core was created, which is currently the only center of this kind in our country, by joining a multidisciplinary team consisting of biomedical engineers, cardiovascular surgeons, anesthesiologists, cardiologists, pathologists, microbiologists and veterinarians, who will continue the research activity in the field of tissue engineering and translate experimental results into clinical activity.
- Published
- 2019
10. Challenges in Perioperative Animal Care for Orthotopic Implantation of Tissue-Engineered Pulmonary Valves in the Ovine Model
- Author
-
Hussam Al Hussein, Hamida Al Hussein, Carmen Sircuta, Ovidiu S. Cotoi, Ionela Movileanu, Dan Nistor, Bogdan Cordos, Radu Deac, Horatiu Suciu, Klara Brinzaniuc, Dan T. Simionescu, and Marius M. Harpa
- Subjects
medicine.medical_specialty ,Heart malformation ,Sedation ,0206 medical engineering ,Biomedical Engineering ,Medicine (miscellaneous) ,02 engineering and technology ,Perioperative Care ,law.invention ,03 medical and health sciences ,law ,medicine ,Cardiopulmonary bypass ,Animals ,Humans ,030304 developmental biology ,Heart Valve Prosthesis Implantation ,0303 health sciences ,Pulmonary Valve ,Tissue engineered ,Sheep ,business.industry ,Mortality rate ,Perioperative ,020601 biomedical engineering ,Surgery ,Disease Models, Animal ,medicine.anatomical_structure ,Pulmonary valve ,Heart Valve Prosthesis ,Anesthetic ,Female ,Original Article ,medicine.symptom ,business ,medicine.drug - Abstract
BACKGROUND: Development of valvular substitutes meeting the performance criteria for surgical correction of congenital heart malformations is a major research challenge. The sheep is probably the most widely used animal model in heart valves regenerative medicine. Although the standard cardiopulmonary bypass (CPB) technique and various anesthetic and surgical protocols are reported to be feasible and safe, they are associated with significant morbidity and mortality rates. The premise of this paper is that the surgical technique itself, especially the perioperative animal care and management protocol, is essential for successful outcomes and survival. METHODS: Ten juvenile and adult female sheep aged 7.8–37.5 months and weighing 32.0–58.0 kg underwent orthotopic implantation of tissue-engineered pulmonary valve conduits on beating heart under normothermic CPB. The animals were followed-up for 6 months before scheduled euthanasia. RESULTS: Based on our observations, we established a guide for perioperative care, follow-up, and treatment containing information regarding the appropriate clinical, biological, and ultrasound examinations and recommendations for feasible and safe anesthetic, surgical, and euthanasia protocols. Specific recommendations were also included for perioperative care of juvenile versus adult sheep. CONCLUSION: The described surgical technique was feasible, with a low mortality rate and minimal surgical complications. The proposed anesthetic protocol was safe and effective, ensuring both adequate sedation and analgesia as well as rapid recovery from anesthesia without significant complications. The established guide for postoperative care, follow-up and treatment in sheep after open-heart surgery may help other research teams working in the field of heart valves tissue regeneration.
- Published
- 2020
11. Minimally Invasive Surgical Protocol for Adipose Derived Stem Cells Collection and Isolation - Ovine Model
- Author
-
Hussam Al Hussein, Marius Harpa, Ionela Movileanu, Hamida Al Hussein, Horatiu Suciu, Klara Branzaniuc, and Dan Simionescu
- Subjects
Pathology ,medicine.medical_specialty ,Isolation (health care) ,business.industry ,Materials Science (miscellaneous) ,Process Chemistry and Technology ,General Engineering ,Adipose tissue ,General Chemistry ,General Medicine ,General Biochemistry, Genetics and Molecular Biology ,Materials Chemistry ,medicine ,General Pharmacology, Toxicology and Pharmaceutics ,business - Abstract
Many methods of stem cells collection and isolation from various tissue types harvested either from small or large experimental animals or from human tissues have been published so far, all evaluating them as a potential source of adult mesenchymal stem cells with applicability in various pathologies or tissue bioengineering. The present study purposed to describe a minimally invasive surgical protocol for adipose tissue collection from sheep�s inter-scapular area. The procedure was carried out on adult sheeps, in aseptic conditions. A light sedation protocol with Detomidine was performed, the recovery from anesthesia being carried out with Atipamezole. Throughout the sedation, the surgical procedure and the recovery from anesthesia, the vital functions of the animal were monitored. The adipose tissue samples collected in sterile tubes with culture medium (Dulbecco�s modified Eagle�s medium - DMEM/10% / FBS10 - fetal bovine serum, 2% antibiotic/antifungal), have been succesfully used by our research team for adipose tissue derived stem cells (ADSCs) isolation for further use in cardiac valves tissue engineering.
- Published
- 2019
12. The implications of Milrinone Lactate in the Postoperative Clinical Management of Surgical Interventions for Congenital Heart Malformations in Children
- Author
-
Mariana Anisoara (Ciorba) Puiac, Horatiu Suciu, Marius Ilie Ciorba, Mihaela Maria Opris, Hussam Al Hussein, Hamida Al Hussein, and Klara Brinzaniuc
- Subjects
medicine.medical_specialty ,Process equipment ,Heart malformation ,Materials Science (miscellaneous) ,Process Chemistry and Technology ,General Engineering ,Milrinone Lactate ,General Chemistry ,General Medicine ,General Biochemistry, Genetics and Molecular Biology ,Materials Chemistry ,medicine ,General Pharmacology, Toxicology and Pharmaceutics ,Intensive care medicine ,Surgical interventions - Abstract
The purpose of the study was to prove to efficacy of Milrinone in the management of open heart surgery in children with congenital heart malformations, the link between Milrinone efficacy and the prevention of low cardiac output syndrome and Milrinone side effects. We conducted a retrospective study on a group of 24 patients, admitted to the Tg Mures Emergency Institute for Cardiovascular Diseases and Transplant, between August 2016 and February 2017. Milrinone was administered to children that underwent open heart surgery for different congenital heart malformations, using doses between 0.25 and 0.75 mcg per kg bodyweight, in continuous intravenous drip, before de-clamping of the Aorta, the procedures being conducted in extracorporeal circulation. We recorded demographic data, biological parameters of renal function, myocardial function and hemodynamic parameters, before and after surgery. The administration of Milrinone determined a reduction of incidence of low cardiac output syndrome, registering only 4 deaths, the survival rate being 83.33%, 13 cases presenting complications. Postoperatively we registered a significant improvement of the mean heart rate. Milrinone proved efficient in the re-establishment of hemodynamic parameters in patients with this type of clinical manifestations. Using Milrinone in children that undergo open heart surgery determines a decrease in incidence of low cardiac output syndrome, its� presence in the pharma market being necessary.
- Published
- 2017
13. Dehydration and Acute Weight Gain of Athletes Before Sport Competitions
- Author
-
Veli Volkan Gurses, Bayram Ceylan, Mustafa Sakir, Bilgehan Baydil, Hamida Al Hussein, and Dana Badau
- Subjects
medicine.medical_specialty ,Process equipment ,biology ,Athletes ,Materials Science (miscellaneous) ,Process Chemistry and Technology ,General Engineering ,030209 endocrinology & metabolism ,030229 sport sciences ,General Chemistry ,General Medicine ,biology.organism_classification ,medicine.disease ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,0302 clinical medicine ,Materials Chemistry ,medicine ,Physical therapy ,Dehydration ,General Pharmacology, Toxicology and Pharmaceutics ,medicine.symptom ,human activities ,Weight gain - Abstract
The aim of this study was to evaluate the extent of acute weight gain, dehydration and rehydration in judo athletes before official competitions. The results showed that judo athletes are competing in dehydrated conditions and thus preventive measurements should be taken to prevent athletes� disadvantageous health circumstances related to acute weight gain and dehydration.
- Published
- 2018
14. Diet, Smoking and Family History as Potential Risk Factors in Acne Vulgaris – a Community-Based Study
- Author
-
Stela Mariana Al Hussein, Hussam Al Hussein, Camil Eugen Vari, Nicoleta Todoran, Hamida Al Hussein, Adriana Ciurba, and Maria Titica Dogaru
- Subjects
medicine.medical_specialty ,family history ,Potential risk ,business.industry ,macromolecular substances ,medicine.disease ,Community based study ,Dermatology ,smoking ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Family medicine ,Medicine ,acne vulgaris ,risk factors ,030212 general & internal medicine ,General Pharmacology, Toxicology and Pharmaceutics ,Family history ,business ,diet ,General Dentistry ,Acne - Abstract
Objective. This study aimed to evaluate the effects of practices and attitudes towards lifestyle in adolescence as risk or protective factors, for both the acne occurrence and lesions’ severity. Methods. A cross-sectional study based on a self-reported questionnaire was conducted during 4 months on 148 high school students, aged 16-20 years, in a high school community of Tîrgu Mureș. Acne prevalence and severity, demographic and anthropometric characteristics, the family history of acne vulgaris, smoking behavior and the weekly intake of certain food categories supposed to increase the risk of acne vulgaris were evaluated. Statistical analysis was performed in terms of Odds ratio, Confidence Interval and Chi-square (p Results. In the investigated community, acne prevalence was found of 47.30%, while 78 subjects (control group) had no facial acne lesions. In acne group: 57.1% had family history of acne, 62.9% were smokers, 22.9% were overweight or obese and 84.3% did not receive any dietary information from specialists. 41.4% were not fish consumers, while 74.3% rarely or never were eating fruits and vegetables. Statistically significant differences between the two analyzed groups were found in terms of sweets, carbonated drinks, dietary fat, white bread, fish, fruits and vegetables weekly intake. Conclusions. Family history, smoking behavior, excessive dietary fat, sweets, carbonated drinks and white bread could be considered as risk factors in acne vulgaris. An increased weekly intake of fish, vegetables and fruits, may have a protective effect in acne development or severity.
- Published
- 2016
15. Eficacy of trichloroacetic acid peel versus 15% topical azelaic acid gel in the treatment of acne vulgaris – a comparative study
- Author
-
Stela Mariana Al Hussein, F. Buicu, Dalila Maier, H. Al Hussein, Adriana Ciurba, Hamida Al Hussein, and Maria Titica Dogaru
- Subjects
endocrine system ,medicine.medical_specialty ,Azelaic acid ,genetic structures ,peel ,business.industry ,Topical treatment ,medicine.disease ,Dermatology ,chemistry.chemical_compound ,topical treatment ,trichloroacetic acid ,azelaic acid ,chemistry ,acne vulgaris ,Medicine ,General Pharmacology, Toxicology and Pharmaceutics ,Trichloroacetic acid ,business ,General Dentistry ,Acne ,medicine.drug - Abstract
Objectives: The aim of this study was to compare the efficacy and tolerability of 20% trichloroacetic acid (TCA) peel with 15% azelaic acid gel, a standard antiacne topical treatment. Materials and methods: 51 patients aged between 16-40 years, with mild and moderate acne, were randomized into two groups. Before the treatment were investigated the patients clinical features and hygienic habits, the previous antiacne treatments and feed-back to them. No cases under treatment with contraceptive pills or antiacne medication that could interfere with the results, were included. For a period of eight weeks, 27 patients (group A) were treated with 15% azelaic acid gel, twice daily, and 24 patients (group B) underwent four sessions of 20% TCA peels, at 14 days interval. The efficacy was evaluated by acne lesions counting, at baseline and at 8 weeks. Adverse effects incidence (erythema, local skin irritation), as well as the satisfaction degree of patients, were investigated. Results: Was observed a mean reduction in the number of acne lesions of 32,36% for the group A and 69,36% for the group B. There was no statistically significant difference between the average number of acne lesions before treatment between the two groups. The mean number of acne lesions after the treatment was significantly different (p Conclusions: TCA peel is an efficient and well tolerated method for the treatment of acne vulgaris.
- Published
- 2015
16. LEG WOUND DEHISCENCE MANAGEMENT AFTER CORONARY ARTERY BYPASS GRAFTING - CASE REPORT.
- Author
-
Hamida, Al Hussein, Cristina, Ciobanu Maria, Andreea, David Camelia, Hermina, Girbovan Anamaria, Daniela, Acatrinei, Cristian, Trâmbi&355;a&351;, and Hussam, Al Hussein
- Subjects
- *
CORONARY artery bypass , *NEGATIVE-pressure wound therapy , *CARDIOVASCULAR surgery , *DYSLIPIDEMIA , *SKIN grafting , *THERAPEUTICS - Abstract
Background: Coronary artery bypass grafting (CABG) is the most common procedure in adult cardiovascular surgery. Great saphenous vein is the most used conduit for coronary revascularization. Leg-wound complications are an underestimated cause of morbidity in CABG patients, causing prolonged hospitalization, antibiotics administration or secondary surgical treatments. Risk factors include female sex, peripheral vascular disease (PVD), diabetes mellitus, smoking, obesity and dyslipidemia. Leg-wound complications vary from mild erythema or secretion to wound dehiscence, infection and skin necrosis. Objective: Underlining the importance of interdisciplinary management in a leg-wound dehiscence (LWD) with unfavorable evolution. Material and methods: A 73-year-old female patient, diagnosed with coronary artery disease, underwent CABG by harvesting the great saphenous vein. Two weeks later, the leg wound started presenting progressive localized necrosis. No purulent secretion was observed and bacteriology culture was negative. Daily dressings and local therapy with an antifungal, antiseptic and re-epithelizing cream were inefficient. Doppler ultrasound revealed hypoperfusion of the lower extremities. Results: Intravenous Pentoxyfillin was administered. Wound debridement followed by application of a negative pressure wound therapy (Vivano device) were performed. One week later, the patient underwent secondary suture of the thigh and a 0,6 mm autologous split-thickness skin graft was stapled on the calf. The evolution was favorable and the patient was discharged after ten weeks of hospitalization, with oral Pentoxyfillin therapy. One month follow-up showed a viable skin graft and healing wound. Conclusions: LWD is an overlooked complication of CABG which can delay recovery and increase morbidity of the patient. Rigorous skin preparation, proper surgical technique and identifying modifiable risk factors can prevent LWD. Skin graft thickness is decisive for the graft viability. Hypovascularization can occur in case of excessive thickness, especially in PVD patients, whereas a too thin graft might get resorbed due to the inflammatory process. Early recognition, prompt intervention and interdisciplinary management are crucial for a favorable outcome. [ABSTRACT FROM AUTHOR]
- Published
- 2019
17. SUTURELESS PERCEVAL AORTIC VALVE REPLACEMENT - CASE REPORT.
- Author
-
Hamida, Al Hussein, Andreea-Cătălina, Munteanu, Ioana-Daniela, Bozdoghina, Ghiragosian, Claudiu, Andreea, David Camelia, Hora&355;iu, Suciu, and Hussam, Al Hussein
- Subjects
- *
AORTIC valve , *DOPPLER ultrasonography , *AORTIC stenosis , *CARDIOPULMONARY bypass , *OPERATIVE surgery - Abstract
Background: Despite the appearance of transcatheter aortic valve implantation (TAVI), classic surgical aortic valve replacement (C-AVR) is still considered the gold-standard treatment of aortic stenosis (AS), at least in low and intermediate risk patients. Recently, The sutureless aortic valve replacement (S-AVR) technique has been introduced, which allows implanting a stented valve without needing sutures. Objective: Efficacy of a new, innovative surgical technique in treating severe AS, one of the first cases in IuBCvT Târgu Mure&351;. Material and methods: A 68-year-old female patient was admitted with progressive exertional dyspnea and fatigue. Echocardiography revealed severe AS with a maximum and mean pressure gradient of 120/67 mmHg, significant valvular calcification and hypertrophied left ventricle with an ejection fraction of 50%. Carotid Doppler ultrasonography and coronary angiography revealed no significant lesions. Contrast CT Scan revealed AS with an aortic annulus of 2,31 cm. Results: The patient underwent S-AVR with a Perceval size L aortic bioprosthesis. During cardiopulmonary bypass (CPB), the native calcified valve was excised and three temporary guiding sutures were placed in the annulus and passed through the eyelets of the valve. Deployment and ballooning of the valve were then performed, and the temporary sutures were removed. Total CPB time was 68 minutes and cross-clamp time was 51 minutes. Postoperative echocardiography revealed a maximum and mean trans-prosthetic pressure gradient of 39/20 mmHg, no paravalvular leak (PVL) or trans-prosthetic regurgitation. Conclusions: Despite its recent introduction, current studies suggest S-AVR as a promising alternative to C-AVR. The major advantage over C-AVR is reduced CPB and cross-clamp duration, which are major determinants in surgical outcome. Furthermore, the advantage over TAVI is direct visualization of the valve, as well as the possibility of calcified valve excision and therefore a lower incidence of PVL. Further studies are needed, but S-AVR could become a new goldstandard in treating AS, especially in high risk patients. [ABSTRACT FROM AUTHOR]
- Published
- 2019
18. Influences of Vitamin A and E supplementation on Haematological, Functional and Oxidative balance parameters on handball players
- Author
-
Dana Badau, Adela Badau, Florin Paraschiv, Liliana Marcela Rogozea, Hamida Al Hussein, and Klara Brinzaniuc
- Subjects
Vitamin ,medicine.medical_specialty ,genetic structures ,business.industry ,Materials Science (miscellaneous) ,Process Chemistry and Technology ,General Engineering ,General Chemistry ,General Medicine ,Oxidative phosphorylation ,General Biochemistry, Genetics and Molecular Biology ,chemistry.chemical_compound ,Endocrinology ,chemistry ,Internal medicine ,Materials Chemistry ,medicine ,General Pharmacology, Toxicology and Pharmaceutics ,business ,Balance (ability) - Abstract
The objective of this study was to evaluate the antioxidant effect of the vitamins A and E before and after intensive aerobic exercise effort and to provide pros and cons arguments on the use of both vitamins during the physical training. The research highlighted important adaptive changes of the functional parameters: PMA, VCEE, VO2max, of the oxidative balance: LPx, MDA, as well as the haematological parameters: HGB, CRT, LYM, LAK.
19. The role of clindamycin phosphate associated with adapalene in three semisolid formulations developed for topical acne treatment
- Author
-
Stela Mariana Al Hussein, Nicoleta Todoran, Silvia Imre, Hussam Al Hussein, Ana Melero Zaera, Hamida Al Hussein, and Maria Titica Dogaru
- Subjects
medicine.medical_specialty ,business.industry ,Materials Science (miscellaneous) ,Process Chemistry and Technology ,General Engineering ,General Chemistry ,General Medicine ,Acne treatment ,Dermatology ,General Biochemistry, Genetics and Molecular Biology ,Adapalene ,Materials Chemistry ,medicine ,Clindamycin Phosphate ,General Pharmacology, Toxicology and Pharmaceutics ,business ,medicine.drug - Abstract
Despite the fact that in mild-to moderate acne vulgaris the standard first-line therapy is the topical treatment with fixed combinations of antimicrobial agents and retinoids, the skin type and the skin barrier function should be taken into account when formulating a topical product. The aim of this study was the comparison of three new semisolid formulations developed for topical application by evaluation of their rheological behavior, as well as the evaluation of in vitro percutaneous diffusion through human epidermis membrane of the pharmaceutical ingredients. Clindamycin phosphate and adapalene were incorporated in three different topical bases, an HPLC method for the determination of their content in the new formulations being developed and validated. A higher concentration of drugs was released from the two gel systems (hydroxypropylmethylcellulose 2.5% -F1 and hydroxyethylcellulose 3% -F2) than from the oil-in-water cream (F3) at pH 7.4, whereas at pH 5.5 the drugs were released in higher amounts from the formulation F3. Following the rheological behavoir associated with the penetrability through the human epidermis membrane, our study results suggest that F1 and F2 could be appropriate in treating acne lesions in patients with oily skin and unaffected skin barrier function. In contrast, the oil-in-water cream (F3), due to its possible emolient effect and its higher penetrability at pH 5.5 than gel vehicles, may be indicated for patients with dry and sensitive skin associated with an altered skin barrier.
20. EXTRAHEPATIC PORTAL VEIN OBSTRUCTION IN CHILDREN: A CASE REPORT.
- Author
-
Hermina, Girbovan Anamaria, Salomea-Ruth, Halmágyi, Hamida, Al Hussein, Mădălina, Grigore, Claudia, Sîrbe, Alina, Grama, and Pop, Tudor L.
- Subjects
- *
ESOPHAGEAL varices , *PORTAL vein , *ASPHYXIA neonatorum , *COLOR Doppler ultrasonography , *UMBILICAL veins , *INTRAVENOUS catheterization , *PORTAL hypertension - Abstract
Background: Extrahepatic portal vein obstruction (EHPVO), although rare in children, is one of the most important causes of noncirrhotic portal hypertension (NCPH) among children. The incidence of EHPVO is estimated to be 0,72/million. The initial clinical manifestation can be represented by upper gastrointestinal bleeding, splenomegaly or ascites. In children, identified risk factors of EHPVO are neonatal vein catheterization, umbilical cord infections, blood transfusions, sepsis, dehydration and coagulation abnormalities. Objective: To present the case of a 9 years old female patient who was hospitalized in a regional hospital with abdominal pain and diarrhea. Two days later she was transferred to our hospital with the suspicion of a malignant hematologic disorder due to important splenomegaly. Material and methods: At the admission in our hospital the clinical exam revealed ponderal hypotrophy and splenomegaly. The patient history determined: small for gestational age, acute fetal distress, perinatal asphyxia, neonatal sepsis, resuscitated cardiac arrest at 2 days of life, cerebral hemorrhage and umbilical vein catheterization. Laboratory findings revealed signs of mild microcytic normochromic anemia associated with thrombocytopenia and leukopenia. The abdominal ultrasonography and color Doppler showed portal vein cavernous transformation, important splenomegaly (123mm), accessory spleen and normal hepatic parenchyma. The upper endoscopy determined 1st grade esophageal varices. The investigations for thrombophilia revealed deficiency of Protein C. Results: The diagnosis of EHPVO was based on splenomegaly, thrombocytopenia due to hypersplenism and the portal cavernoma. Sepsis and umbilical vein catheterization in neonatal period associated with deficiency of protein C were the risk factors for EHPVO in our patient. Conclusions: EHPVO represents a rare disorder in children having similarities with the malignant hemopathies. NCPH represents an uncommon cause of portal hypertension in children and the main cause is represented by EHPVO. The major risk factor is represented by the umbilical vein catheterization, therefore close follow up should be conducted in these cases. [ABSTRACT FROM AUTHOR]
- Published
- 2019
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.