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Background: Bardoxolone inhibited proliferation and induced apoptosis in vitro in wide types of human cancer cells. It has also been shown to inhibit the growth of tumor in the mice model. Several studies demonstrated that bardoxolone may modulate multiple molecular targets that have a fundamental role in both the development and progression of cancer. Objectives: The aim of this study is to assess the effects of Bardoxolone (CDDO-Me) in the treatment of colonic carcinoma by induction of the nuclear factor erythroid 2-related factor 2 signaling pathway (Nrf2) with regression of tumor markers as compared to other chemotherapeutic agents like 5-fuorouracil. Materials and Methods: Treatment groups are classified into four groups (control, chemotherapy group, bardoxolone, and combination treatment groups). Results: The results revealed that there were significant effects of bardoxolone treatment on cytoplasmic Nrf2 level (P < 0.05) as compared to control group (cancer cells without treatment). Conclusion: Bardoxolone has significant anticancer effects (P < 0.05) in low micrograms concentrations on human colonic cancer cells as compared to control groups.

Background and Objective: Cognitive behavioral therapy based on religion can increase the religious mind. This study was done to evaluate the effectiveness of cognitive behavioral therapy based on religion on depression and quality of life in patient with HIV/AIDS. Methods: In this quasi -experimental study with pretest, post test and follow up with control group, 30 patients with HIV were non-randomly divided into intervention and control groups. Patients in intervention group were received 12 sessions of cognitive behavioral therapy based on religion, but patients in control group did not receive any intervention. Beck depression test (BDI-II) and quality of life questionnaire (WHOQOL-Brief) were used. Results: The rate of depression in intervention group significantly reduced in compared to controls (P

Objective This study was performed to evaluate the anticancer effect of live attenuated measles virus (Edmonston strain) on human lung cancer cell line in vitro. Methods Human lung cancer cell line (A549) was treated with different titers of the propagated live attenuated measles virus on Vero cells, including 10−1, 10−2, 10−3, 10−4, 10−5 of virus stock (8.860 log10 RNA copies/μl). The virus cytopathic effect (CPE) was studied at 24, 48, 72, and96 hr. Oncolytic effects of the virus were assessed by cytotoxicity assay, apoptosis analysis, and proliferation marker Ki-67. The growthinhibition pe rcentage was determined by ELISA reader using crystal violet staining assay and compared with the viral load measured byquantitative real time-PCR. Results The results of the study showed that measles virus had an inhibitory effect on the growth of human lung cancer cell line comparedwith untreated control group. There was highly significant positive correlation between viral load and PGI at 24, 48, 72, 96 hr (P < 0.001).The growth inhibition rate of a cell was associated with a decrement in t he expression of the Ki-67 protein and increase in the ratio of earlyand late apoptotic cells in comparison with untreated control group. Conclusion Live attenuated measles virus strain induced cytotoxic effect against human lung cancer cell line (A549) by induction of apoptosis as an important mechanism of anti-tumor activity, in addition, it indicates a correlation between the quantity of MV genomesand percentage of growth inhibition. This relation has proved that measles virus had anticancer effect.

Background: Job stressors in managers are progressively affecting and destroying their immune systems. The relationship between hardiness, stress and immune system is important for mental health. This study was designed to determine the resources in managers against stress, resources herein designated as “hardiness” and “social support". Also in this research, the correlation between hardiness, defined collectively as feelings of challenge, commitment and control, as a resource against stress and the immune system of high school managers in Khozestan Province were studied. Methods: The study sample was comprised of 340 managers (male and female), selected by the cluster sampling method. Each subject completed the personal view survey scale and social support questionnaire. Then the individuals were divided into four groups (n= 35 in each group) of high and low hardiness and social support as follows: high hardiness / high social support, high hardiness / low social support, low hardiness / high social support and low hardiness / low social support. Subjects who suffered from disorders that affect the immune system were excluded. The number of T-helper cells (CD4), T-suppressor cytotoxic cells (CD8), natural killer cells (CD56+ CD16), complement system (C3, C4, CH50), immunoglobulin M and G (IgM and IgG), cortisol hormone, eosinophils, neutrophils and lymphocytes were measured for each subject. Results: The results revealed that, there was a significant positive correlation between hardiness and CD4, CD4/CD8, CD56, CD16, CH50, IgM and neutrophil levels. Also, there was a significant negative correlation between hardiness and CD8, cortisol and eosinophil levels. There was a significant difference between the four groups of in CD4, CD8, CD4/CD8, cortisol, C3, C4, CH50 and lymphocyte levels. Also, there was a significant positive correlation between social support and CD4, CD4/CD8, CD56, CD16, CH50, IgM, C3 and neutrophil levels. Conclusions: The results revealed that the performance of the immune system in managers with high hardiness and high social support is significantly better than that of managers with low hardiness and low social support. Furthermore, high hardiness and high social support act as resources and moderating factors against stress.

Background&Objective: Stress in managers will effect and destroy the immune system on mental health. Clinical studies have revealed that, social support is one of the moderating factors of negative effect of stress on immune system. The aim of this research was study the correlation between social support and immune system of high school managers in khozestan province. Materials&Methods: An experimental study was conducted on 360 male and femal managers who were participated. Then randomly two groups (n=80 in each group) of low and high social support were selected. Subjects who suffered from disorders that affected the immune system were excluded. Number of T-helper cells (CD4), T-suppressor cytotoxic cell (CD8), Natural killer cells (CD56+CD16), Complement system (C3,C4,CH50), Immunoglobulin M and G (IgM&IgG), cortisol hormone, Eosinophils, Neutrophils and Lymphocytes were measured. Results: There was a significant positive correlation between social support and CD4, CD4/CD8, NK cell (CD56+CD16), CH50, IgM and Neutrophils. Also there was a significant negative correlation between social support and CD8, cortisol and Eosinophils. There was a significant difference between high and low social support managers in CD4, CD4/CD8, CD8, cortisol, CH50, C4, C3 and Lymphocytes. Conclusion: The results indicated that social support has a positive significant correlation with those immune cells that improve the immune system and has a negative correlation with those immune cells that decerase the immune system. In fact the social support is a moderating factor angainst stress and its negative effects on immune system.