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Background: Sexual dysfunction (SD) is the most common and challenging complication among women with multiple sclerosis (MS). Despite investigations into the impact of taking vitamin D on sexual function (SF), findings have not definitively recommended its use. This study aimed to evaluate the effects of vitamin D supplementation on SF and sex hormones among women with MS. Methods: This triple-blind, randomized, placebo-controlled clinical trial was conducted on 62 married women with MS and vitamin D deficiency. They were recruited from a specialized clinic for neurology in Tehran City, Iran, between August 2017 and February 2018. The subjects were randomly allocated to experimental or control groups (n=31/each group). Subjects in the experimental and control groups, respectively, received two 2000-IU vitamin D and two placebo tablets daily for 12 consecutive weeks. Serum levels of sex hormones and their SF were evaluated before and after the intervention. The SF assessment was performed using the female SF index. The obtained data were analyzed using an independent samples t-test, paired t-test, Fisher exact test, Mann-Whitney U test, and the chi-square test in SPSS software, version 22. The significance level was determined at

Abstract The earliest archaeological evidence from northern Africa dates to ca. 2.44 Ma. Nevertheless, the palaeoenvironmental setting of hominins living in this part of the continent at the Plio-Pleistocene transition remains poorly documented, particularly in comparison to eastern and southern Africa. The Guefaït-4 fossil site in eastern Morocco sheds light on our knowledge of palaeoenvironments in northern Africa. Our study reveals the oldest known presence of C4 plants in the northern part of the continent in a mosaic landscape that includes open grasslands, forested areas, wetlands, and seasonal aridity. This diverse landscape and resource availability likely facilitated the occupation of the region by mammals, including potentially hominins. Our regional-scale study provides a complementary perspective to global-scale studies and highlights the importance of considering the diversity of microhabitats within a given region when studying species-dispersal dynamics.

Meeting the needs of today’s industry plays a prominent role in the progress and competitive strength of any country. Therefore, it is necessary to align the curriculum of engineering courses with them. In this research, the focus has been on the mechanical engineering curriculum, especially in the universities of Iran. For this purpose, first by surveying the industry owners and reviewing the literature, these expectations have been identified and prioritized. Accordingly, the most important of these needs are creativity, visualization ability, familiarity with manufacturing processes, and agility in learning new concepts. Then, using a twostage quality function deployment method (QFD), these expectations are translated into curriculum specifications. The results show that the most effective groups of courses in this field are elective courses, skill courses such as engineering graphics (including technical drawing and drawing courses), design of machine components, and practical workshops. In the existing programs, compared to courses in specialized theory and basic courses, some of them have received less considerable attention in quantity and quality

Abstract In this work, we demonstrate that palladium-immobilized triazine dendrimer on magnetic nanoparticles in proper solvents, provides an impressive, atom-economical and compelling approach for the selective synthesis of 2,3-diphenylindole or pentaphenylpyrrole derivatives via annulation of diphenylacetylene with diverse anilines. Both the annulation methods were taken place under copper- and phosphine-free conditions with high yields at air atmosphere. Likewise, bis-indoles were obtained with excellent yields under optimized reaction conditions. Besides, the catalyst was isolated and reused for seven cycles without decrease potential of catalytic activity. Two mechanistic pathways were proposed and geometry optimizations, electronic properties as well as vibrational characterizations of all structures were performed with density functional theory (DFT). Also, the investigation of atomic basin properties of these molecular systems was carried out utilizing the quantum atoms-in-molecules theory (QTAIM). The results showed that 2,3-diphenylindole and pentaphenyl pyrrole molecular systems can be used as intramolecular acceptor/donor (n-like/p-like) sections.

Abstract Background Chickpea is a key pulse crop grown in the spring in dryland regions. The cold resistance potential of chickpeas allows for the development of genotypes with varying sowing dates to take advantage of autumn and winter rainfall, particularly in dryland regions. In this study, we assessed grain yield, plant height, 100-seed weight, days to maturity, and days to flowering of 17 chickpea genotypes in five autumn-sown dryland regions from 2019 to 2021. Additionally, the response of selected chickpea genotypes to cold stress was examined at temperatures of -4 °C, 4 °C, and 22 °C by analyzing biochemical enzymes. Results Mixed linear model of ANOVA revealed a significant genotype × environment interaction for all traits measured, indicating varying reactions of genotypes across test environments. This study reported low estimates of broad-sense heritability for days to flowering (0.34), days to maturity (0.13), and grain yield (0.08). Plant height and seed weight exhibited the highest heritability, with genotypic selection accuracies of 0.73 and 0.92, respectively. Moreover, partial least square regression highlighted the impactful role of rainfall during all months except of October, November, and February on grain yield and its interaction with environments in autumn-planted chickpeas. Among the genotypes studied, G9, G10, and G17 emerged as superior based on stability parameters and grain yield. In particular, genotype G9 stood out as a promising genotype for dryland regions, considering both MTSI and genotype by yield*trait aproaches. The cold assay indicated that − 4 °C is crucial for distinguishing between susceptible and resistant genotypes. The results showed the important role of the enzymes CAT and GPX in contributing to the cold tolerance of genotype G9 in autumn-sown chickpeas. Conclusions Significant G×E for agro-morphological traits of chickpea shows prerequisite for multi-trial analysis. Chickpea`s direct root system cause that monthly rainfall during plant establishment has no critical role in its yield interaction with dryland environment. Considering the importance of agro-morphological traits and their direct and indirect effects on grain yield, the utilization of multiple-trait stability approches is propose. Evaluation of chickpea germplasm reaction against cold stress is necessary for autumn-sowing. Finally, autumn sowing of genotype FLIP 10–128 C in dryland conditions can led to significant crop performance.

Abstract Recently, increased attention has been paid to the raw materials of plants as a source of biologically active substances. Black rosehip (Rosa pimpinellifolia L.) fruits could be a good resource for potential functional components in the food, cosmetic and pharmaceutical industries. Also, drying can influence the composition of heat-sensitive phytochemicals. However, less attention is given to comparing black rosehip bioactive compounds particularly compositions of fatty acid, amino acids, and phenolic content in fresh and dried fruits. So in this study, the amino acid constituents (by amino acid analyzer), fatty acids (by GC–MS), mineral elements (by atomic absorption spectrometer), antioxidant (by DPPH) and phenolic compounds (by HPLC) present in fresh and dried fruits of black rosehip naturally grown in Iran were comprehensively investigated. The results showed that dried fruits had a lower level moisture by 51.55%, and a higher level of total phenolic compounds and total sugar by 786.20 mg GAE/100 g and 15.77 g/100 g, respectively. Chlorogenic acid and gallic acid were the major phenolic compounds (109.3 mg/g). Whilst, linoleic acid, oleic acid, and arachidic acid (85.34%) were the most dominant fatty acids. The most dominant amino acids were glutamic acid, phenylalanine, and arginine (29.41 g/100 g). Also, Fe and Mn as micro-elements were the most dominant elements. In general, the results illustrated the potentials and differences of black rosehip fruits grown in the Arasbaran region as promising resources for food sources, pharmaceutics, cosmetics, and breeding programs. Also, these findings confirm that black rosehip fruits contain significant amounts of secondary metabolites that may positively affect human health.

Objective(s): Polycystic ovary syndrome (PCOS) is a complex metabolic and endocrine disorder associated with chronic inflammation. However, the effect of ∆9 Tetrahydrocannabinol (THC) on PCOS has not been evaluated. Therefore, this study aimed to investigate the immunomodulatory effects of THC in an animal model of PCOS. Materials and Methods: Twenty female Sprague-Dawley rats, aged 4 weeks, were divided into four groups. The control group received a normal diet, the sham group received a vehicle (carboxymethyl cellulose), the PCOS group received a high-fat diet (HFD) for 16 weeks followed by letrozole for 4 weeks, and the THC group received an HFD for 16 weeks followed by letrozole+THC (0.02 mg/kg) for 4 weeks. Results: The PCOS animals exhibited significantly higher levels of testosterone, insulin, triglycerides, and total cholesterol, along with elevated inflammatory and oxidative stress markers compared to the control group. Flow cytometry and real-time PCR analysis revealed an increase in M1 macrophage markers and a decrease in M2 macrophage markers compared to the control group. However, the administration of a low dose of THC mitigated these disturbances.Conclusion: Low-dose THC improved inflammatory responses and shifted the balance of M1/M2 macrophage markers towards M2 macrophages in the animal model of PCOS.

This research focuses on the effect of mat water spraying on the production yield and the quality of medium density fiberboard (MDF) on an industrial scale at Arian Sina MDF Company. A total of 180 raw medium density fiberboard panels, each with dimensions of 3.66×1.83×0.016 m, manufactured by the company in 2018, have been used as the experimental samples. These samples have been produced under various conditions, including 3 different groups: 1 – without mat water spraying; 2 and 3 – with mat water spraying using 40 and 50 g/m² of water, correspondingly. Other parameters have included a constant adhesive content (10 % of dry fiber content), a fixed mat moisture content (7 %), and the use of poplar species (70 %) and Eucalyptus camaldulensis (30 %). Additionally, a hardener (at 0.8 % of the dry weight of glue) has been applied. The results have demonstrated that water spraying onto both sides of the mat increases the strength properties and improves the production yield. This enhancement is attributed to the reduced time required for transferring heat from the press plates to the core layer of the mat. Furthermore, X-ray vertical profile density analysis has indicated that water spraying onto the mat surface also increases the surface and core layer density of the panels.

Background: Patients with heart failure experience poor sleep quality due to the nature of disease they suffer from. The aim of this study was to investigate the effect of music on the sleep quality of patients with heart failure. Materials and Methods: The present study is a randomized clinical trial, which was performed on 76 patients with heart failure, hospitalized in the cardiac ward of an educational hospital. These patients had obtained a score of 5 or higher on Pittsburgh’s sleep quality index. The block randomization method was used to generate the allocation sequence. Thus, the number of subjects in each block was determined to be 4 people in 18 blocks. Intervention was collection of nature music played through headphones for 30 minutes over three nights, and at the end of the third night, the Pittsburgh’s index was completed again by both groups. Data were analyzed using descriptive and inferential statistics. Results: After the intervention, the mean scores of mental quality of sleep (p = 0.007) and daily function disorders improved significantly in the intervention group (p = 0.025). Significant differences were seen between the mean scores of mental quality of sleep (p < 0.001), daily function disorders (p = 0.002), delay in falling asleep (p = 0.01), sleep disorders (p < 0.001), and use of sleeping pills (p < 0.001) before and after the intervention in the intervention group. Conclusions: Playing relaxing music like nature sounds and spending time in nature after discharge can improve the sleep quality and sense of relaxation in patients with heart failure. The implementation of such affordable and amusing interventions can be proposed by nurses in heart failure patients.

Introduction One of the most important global challenges is food waste, about 30% of the world's agricultural land is wasted. Every year, about 9.5 million tons of food is lost in the post-harvest phase of agriculture. Therefore, storage technology is very important to increase shelf life, preserve nutrition and maintain the taste of fresh products. Storing strawberry fruits at an inappropriate temperature after harvesting significantly increases weight loss, rotting and softening. L-phenylalanine as an amino acid is used for the biosynthesis of all phenolic compounds through the phenylpropanoid pathway. In recent years, the application of exogenous phenylalanine has been considered for use as a biologically safe molecule to maintain the postharvest quality of many horticultural crops. L-phenylalanine treatment has been reported to reduce the frost damage of plum fruit during cold storage by maintaining membrane integrity and improving reactive oxygen species (ROS) scavenging capacity. The treated fruit showed a higher DPPH inhibition capacity by increasing the accumulation of phenolic compounds and antioxidant enzyme activity. Aghdam et al. (2019) also reported that application of L-phenylalanine significantly reduced cold damage, membrane lipid peroxidation and ROS accumulation in tomato fruits during cold storage. Materials and Methods Strawberry fruits were obtained from a commercial greenhouse located in Urmia at full maturity stage. The fruits were transported to the laboratory of the Department of Horticultural Sciences in Urmia University with necessary precautions to prevent any mechanical damage to the product. The fruits were separated in terms of size and uniformity, so that the fruits were divided into 3 groups, one group as a control group and 2 groups were treated with concentrations of L-phenylalanine (4 and 8 mM). After drying the treated fruits, they were placed in zipped nylon bags and kept in a cold room for 15 days at a temperature of 3 ± 0.5 °C and a relative humidity of 90-95%. Also, three biological replicates at each time point were included in the analysis. The samples obtained at each of these times were used to evaluate skin color, titratable acidity, soluble solids, taste index, pH, weight loss, firmness, antioxidant capacity, total phenol content, and polyphenol oxidase enzyme activity. Results and Discussion The results showed that the effect of post-harvest treatment, storage time, and the interaction between them were statistically significant on all of the traits. In terms of color changes, the effect of post-harvest treatment (p≤0.05) was significant only in b* index, and the highest rate was observed in the 4 Phe treatment. The effect of storage time was also significant in a* and Chroma indices (p≤0.05) and the highest level was observed in both of these indices at day 5. The effect of storage time was also significant in TA (p≤0.01), the highest value was observed in day 10. In antioxidant capacity (p≤0.05), TSS (p≤0.05) and taste index (p≤0.01), the interaction effect between storage time and Phe treatment was significant. In antioxidant capacity, the highest percentage of DPPH inhibition was observed in day 10 and 4 Phe treatment, in TSS, the highest rate was observed on day 10 and 8 Phe treatment, and in taste index, the highest rate was observed on day 15 and 4 Phe treatment. The effect of post-harvest Phe treatment and storage period on fruit weight loss was significant (p≤0.05) and (p≤0.01) respectively, and the lowest percentage of weight loss was observed in Phe 4 and day 5. In terms of firmness and total phenol content, only the effect of Phe treatment was significant (p≤0.05) and (p≤0.01), respectively, the highest level of firmness in the 4 Phe treatment and the highest amount of total phenol content in the 8 Phe treatment were observed. In the PPO enzyme, only the effect of storage time (p≤0.05) was significant. Conclusion According to the obtained results, the 4 Phe treatment is the best concentration of phenylalanine to increase the shelf life of harvested strawberry fruits under cold storage.

Abstract Rainfed regions have inconsistent spatial and temporal rainfall. So, these regions could face water deficiency during critical stages of crop growth. In this regard, multi-environment trials could play a key role in introducing stable genotypes with good performance across several rainfed regions. Grass pea, as a potential forage crop, is a resilient plant that could grow in unsuitable circumstances. In this study, agro-morphological attributes of 16 grass pea genotypes were examined in four semi-warm rain-fed regions during the years 2018–2021. The MLM analysis of variance showed a significant genotype-by-environment interaction (GEI) for dry yield, seed yield, days to maturity, days to flowering, and plant height of grass pea. The PLS (partial least squares) regression revealed that rainfall in the grass pea establishment stage (October and November) is meaningful. For grass pea cultivation, monthly rainfall during plant growth is important, especially in May, with an aim for seed yield. Regarding dry yield, G5, G10, G11, G12, G13, and G15 were selected as good performers and stable genotypes using DY × WAASB biplots, while SY × WAASB biplot manifested G2, G3, G12, and G13 as superior genotypes with stable seed yield. Considering equal weights for yield as well as the WAASB stability index (50/50), G13 was selected as the best one. Among test environments, E2 and E11 played a prominent role in distinguishing the above genotypes from other ones. In this study, MTSI (multi-trait stability index) analysis was applied to select a stable genotype, considering all measured agro-morphological traits simultaneously. Henceforth, the G5 and G15 grass pea genotypes were discerningly chosen due to their commendable performance in the WAASBY plot. In this context, G13 did not emerge as the winner based on MTSI; however, it exhibited an MTSI value in close proximity to the outer boundary of the circle. Consequently, upon comprehensive consideration of all traits, it is deduced that G5, G13, and G15 can be appraised as promising superior genotypes with stability across diverse environmental conditions.

The functionality of human intelligence relies on the interaction and health of neurons, hence, quantifying neuronal morphologies can be crucial for investigating the functionality of the human brain. This paper proposes a deep learning (DL) based method for segmenting and quantifying neuronal structures in fluorescence microscopy images of developing neuronal cells cultured in vitro. Compared to the majority of supervised DL-based segmentation methods that heavily rely on creating exact corresponding masks of neuronal structures for the preparation of training samples, the proposed approach allows for imperfect annotation of neurons, as it only requires tracing the centrelines of the neurites. This ability accelerates the preparation of training data by several folds. Our proposed framework is built on a modified version of PSPNet with an EfficientNet backbone pre-trained on the CityScapes dataset. To handle the imperfectness of training samples, we incorporated a weighted combination of two loss functions, namely the Dice loss and Lovász loss functions, into our network. We evaluated the proposed framework and several other state-of-the-art methods on a published dataset of approximately 900 manually quantified cultured mouse neurons. Our results indicate a close correlation between the proposed method and manual quantification in terms of neuron length and the number of branches while demonstrating improved analysis speed. Furthermore, the proposed method achieved high accuracy in neuron segmentation, as evidenced by the evaluation of the neurons’ length and number of branches.

The potential of L-glutathione (GSH) (0, 4, 16, 32 and 64 mM) to improve the post-harvest quality and antioxidant capacity of strawberries was investigated during storage (0, 5, 10, and 15 days) in this study. Results showed that weight loss in fruits treated with 64 mM GSH was significantly lower than the control. GSH treatments resulted in higher levels of total phenol content and antioxidant capacity in treated fruits of strawberry. Based on the results, GSH 64 mM significantly increased the levels of total flavonoid, anthocyanin, ascorbic acid, total soluble protein, antioxidant enzymes such as catalase (CAT), superoxide dismutase (SOD), guaiacol peroxidase (POD), ascorbate peroxidase (APX) and Phenylalanine ammonia-lyase (PAL). In addition, GSH 64 mM decreased Malondialdehyde (MDA) levels and prevented cell membrane lipid peroxidation. In conclusion, the results of the present study showed that the use of GSH 64 mM may be a promising strategy to improve the marketability, quality and antioxidant capacity of strawberry fruits during storage.

During the past few decades, abundant evidence for physics beyond the two standard models of particle physics and cosmology was found. Yet, we are tapping in the dark regarding our understanding of the dark sector. For more than a century, open problems related to the nature of the vacuum remained unresolved. As well as the traditional high-energy frontier and cosmology, technological advancement provides complementary access to new physics via high-precision experiments. Among the latter, the Casimir And Non-Newtonian force EXperiment (Cannex) has successfully completed its proof-of-principle phase and is going to commence operation soon. Benefiting from its plane parallel plate geometry, both interfacial and gravity-like forces are maximized, leading to increased sensitivity. A wide range of dark sector forces, Casimir forces in and out of thermal equilibrium, and gravity can be tested. This paper describes the final experimental design, its sensitivity, and expected results.

Abstract Background Impaired immune response in multiple myeloma renders the patients vulnerable to infections, such as COVID-19, and may cause worse response to vaccines. Researchers should analyze this issue to enable the planning for special preventive measures, such as increased booster doses. Therefore, this meta-analysis aimed to evaluate the response and efficacy of COVID-19 vaccines in patients with multiple myeloma. Methods This meta-analysis followed PRISMA 2020 guidelines, conducting a comprehensive database search using specified keywords. Study selection involved a two-phase title/abstract and full-text screening process. Data extraction was performed by two researchers, and statistical analysis involved meta-analysis, subgroup analysis based on vaccine dosage and study time, random effects meta-regression, and heterogeneity testing using the Q test. Results The meta-analysis revealed that patients with multiple myeloma (MM) had a lower likelihood of developing detectable antibodies after COVID-19 vaccination compared to healthy controls (Log odds ratio with 95% CI: -3.34 [-4.08, -2.60]). The analysis of antibody response after different doses showed consistent lower seropositivity in MM patients (after first dose: -2.09, [-3.49, -0.69], second: -3.80, 95%CI [-4.71, -3.01], a booster dose: -3.03, [-5.91, -0.15]). However, there was no significant difference in the mean level of anti-S antibodies between MM patients and controls (Cohen’s d -0.72, [-1.86, 0.43]). Evaluation of T-cell responses indicated diminished T-cell-mediated immunity in MM patients compared to controls. Seven studies reported clinical response, with breakthrough infections observed in vaccinated MM patients. Conclusions These findings highlight the impaired humoral and cellular immune responses in MM patients after COVID-19 vaccination, suggesting the need for further investigation and potential interventions.

Abstract Background The current report investigates fusion rates and patient-reported outcomes following lumbar spinal surgery using cellular bone allograft (CBA) in patients with risk factors for non-union. Methods A prospective, open label study was conducted in subjects undergoing lumbar spinal fusion with CBA (NCT 02969616) to assess fusion success rates and patient-reported outcomes in subjects with risk factors for non-union. Subjects were categorized into low-risk (≤ 1 risk factors) and high-risk (> 1 risk factors) groups. Radiographic fusion status was evaluated by an independent review of dynamic radiographs and CT scans. Patient-reported outcome measures included quality of life (EQ-5D), Oswestry Disability Index (ODI) and Visual Analog Scales (VAS) for back and leg pain. Adverse event reporting was conducted throughout 24-months of follow-up. Results A total of 274 subjects were enrolled: 140 subjects (51.1%) were categorized into the high-risk group (> 1 risk factor) and 134 subjects (48.9%) into the low-risk group (≤ 1 risk factors). The overall mean age at screening was 58.8 years (SD 12.5) with a higher distribution of females (63.1%) than males (36.9%). No statistical difference in fusion rates were observed between the low-risk (90.0%) and high-risk (93.9%) groups (p > 0.05). A statistically significant improvement in patient-reported outcomes (EQ-5D, ODI and VAS) was observed at all time points (p

Acanthamoeba, a widely distributed free-living amoeba with 20 genotypes identified through rRNA gene sequencing, exhibits varying degrees of pathogenicity influenced by its genotype. This study focuses on assessing the prevalence of Acanthamoeba species in the surface waters of Ilam, located in western Iran, utilizing morphological analysis and sequencing of the 18S rRNA gene through the PCR method. A total of 50 water samples were collected from various regions within Ilam city, situated in the southwest of Iran. To isolate Acanthamoeba parasites from the samples, a culture method was used, and all utilized culture media were scrutinized through microscopic and molecular techniques. The parasite's genotype was determined by sequencing a 500-bp fragment of the 18S rRNA gene. Using microscopic and molecular methods, 19 and 16 water samples tested positive, respectively. The 18S rRNA sequences revealed that the isolates belonged to the T4, T2, and T11 genotypes. This study emphasizes the presence and inclination for close contact with highly pathogenic genotypes of Acanthamoeba in the surface waters of Ilam City. HIGHLIGHTS This study showed the widespread prevalence of Acanthamoeba in water resources.; Using microscopic and molecular methods, 19 and 16 water samples were found positive, respectively.; The 18S rRNA sequences showed that the isolates belong to the T4, T2, and T11 genotypes.; The 18S rRNA gene sequence showed the presence of T4, a highly pathogenic genotype with the highest frequency in the surface water of Ilam.;

Background: The aim of this study was to evaluate the effects of thiamine (vitamin B1) on general health and infertilitytreatment outcomes in women with polycystic ovary syndrome (PCOS).Materials and Methods: The study is a triple-blinded, randomized, placebo-controlled clinical trial performed on 64 infertilewomen with PCOS referred to Sarem Hospital in Tehran, Iran. The primary outcomes of the study were general healthand infertility treatment outcomes. Eligible women were randomly assigned to the vitamin B1 group (n=32, vitamin B1tablet at a dose of 300 mg/day for 4 weeks) or the placebo group (n=32, placebo tablet daily for 4 weeks). A general healthquestionnaire was completed before and after the intervention by both groups and treatment success was evaluated at theend of the study. Data were analyzed using SPSS software ver.16 P

The purpose of this research was to investigate the effectiveness of executive functions training program on sleep quality and moral judgment of children with attention deficit/hyperactivity disorder. The research method was semi-experimental with a pre-test-post-test design and follow-up with a control group. The statistical population of the research included all 9-12-year-old boys with attention deficit/hyperactivity disorder in Urmia city in 2022. The sample size includes 30 subjects from the statistical population were selected by available sampling method and they were placed in two control and experimental groups. The research tools included the Child Sleep Habits Questionnaire and the moral judgment Test. The results showed that the training program of executive functions had a significant effect on improving sleep quality and moral judgment in the post-test and follow-up stages. The findings of this research provide useful information related to the executive functions program, and counselors and psychologists can use this intervention to improve sleep quality and moral judgment in children with attention deficit/hyperactivity disorder.

The use of dental implants to restore edentulous jaws has become commonplace. Usually, in the maxilla, following a tooth extraction, the height of alveolar bone decreases. This alteration in bone increases the risk of implants migrating into the sinus. In general, Caldwell-Luc and endoscopic surgery are performed to retrieve dental implants. In this case series, we collected data from 39 patients who had the complication of implant displacement within the maxillary sinus for 25 years. All the implants were removed using the Caldwell-Luc technique. Implant migration happened following functional loading, during the prosthetic procedure, due to lack of osseointegration in 3 patients, and during implant placement into the fresh socket in 3 patients. In the remaining cases, migration occurred preoperatively or postoperatively and prior to implant loading. Insufficient bone quantity is sometimes causing the implant to migrate to the maxillary sinus. In case of minimal bone height, a sinus lift before implant placement should be conducted. Retrieval of an implant pushed inside the maxillary antrum using the Caldwell Luc approach proved to be a reliable technique.

Objective: Morphine exposure during pregnancy has detrimental effects on both the mother and her offspring, both during and after childbirth. This study aimed to investigate the impact of prenatal morphine exposure on rat pups and dams, specifically focusing on changes in Neuregulin-1 (Nrg-1)/ErbB4 gene expression, inflammation, and brain-derived neurotrophic factor (BDNF) levels. Materials and methods: Twenty female rats were randomized into two experimental groups:1-Morphine Group: Dams received morphine throughout pregnancy. 2-Control Group: Dams received no interventions.At the end of gestation, blood samples were collected from the dams. Subsequently, dams and their pups underwent tissue collection from the cortical area of the brain to evaluate the following parameters: Interleukin-6 (IL-6), Interleukin-10 (IL-10), total antioxidant capacity (TAC), Malondialdehyde (MDA), and Brain-derived neurotrophic factor (BDNF).Additionally, RNA was extracted from the pup's cortical brain tissue for the assessment of gene expression levels of Neuregulin-1 (NRG-1) and ErbB-4 using quantitative real-time polymerase chain reaction (qrt-PCR). Results: The molecular investigation revealed a decrease in NRG-1 and ErbB-4 expressions in the brain cortex of offspring exposed to morphine during prenatal development. Additionally, the levels of IL-6 and IL-10 in both the serum and brain of both the mothers and their offspring in the morphine group were significantly higher compared to the control group. The morphine-exposed group also exhibited significantly lower levels of TAC and higher levels of MDA, indicating increased oxidative stress. Furthermore, the levels of BDNF in the morphine group were significantly lower compared to the control group. Conclusion: Prenatal morphine exposure in rats has detrimental effects on both the dams and their offspring. This study demonstrates that prenatal morphine exposure disrupts critical molecular pathways involved in neurodevelopment, inflammation, oxidative stress, and neurotrophic signaling. These findings suggest that prenatal morphine exposure can have long-lasting consequences for the offspring, potentially contributing to neurodevelopmental disorders and other health issues later in life.

Social isolation (SI) after stroke reduces recovery. The aim of this study was to evaluate the effects of SI on corticosterone release and recovery after stroke in aged rats. A total of 64 male Wistar rats (aged 24 months) were used in the present study. All rats were housed in pairs for two weeks. After two weeks, rats were randomly assigned to one of four groups: (1) rats underwent sham surgery and kept socially isolated (control/social isolated (CO/SI) group); (2) rats underwent sham surgery and kept pair housed (control/pair housed (CO/PH) group); (3) rats underwent middle cerebral artery occlusion (MCAO) surgery and kept socially isolated (stroke/isolated (ST/SI) group); (4) rats underwent MCAO surgery and kept pair housed (stroke/pair housed (ST/PH)) group. Behaviors were assessed using the adhesive removal test, rotarod test and social interaction test at 1st, 7th, 14th and 21st days after stroke. Serum biochemical analysis was also performed on the behavioral testing days. Results showed THAT serum corticosterone and MDA levels in CO/PH group were significantly lower than CO/SI group. Serum BDNF levels in CO/PH group was significantly higher than CO/SI group. Serum corticosterone and MDA levels in ST/PH group were lower than ST/SI group. In ST/PH group, serum Total antioxidant capacity (TAC) and BDNF levels were significantly higher than ST/SI group. Biochemical analysis of certain regions of the brain (hippocampus, striatum and cerebral cortex) was performed on 21st day after stroke. In the hippocampus of CO/PH group, BDNF and TAC levels were significantly higher than CO/SI group. The hippocampal MDA level of CO/PH group were significantly lower than CO/SI group. BDNF and TAC levels in the hippocampus, striatum and cerebral cortex of ST/PH group were significantly higher and MDA level was significantly lower as compared with ST/SI group. Both ischemic groups showed sensorimotor recovery over a 21-day period, but recovery of ST/PH group was significantly greater than ST/SI group. Total social interaction time in ST/PH group was significantly longer than ST/SI group. Based on the results of this study, social interaction after stroke enhances histologic and sensorimotor recovery through reduction of HPA activity and corticosterone release, leading to increased TAC and BDNF levels.

Background & Aims Health workers during the COVID-19 pandemic had high responsibilities of prevention and treatment, which can cause anxiety in them considering the negative effects of the pandemic on mental health. This study aims to investigate the COVID-19-related anxiety level and its relationship with job burnout in health workers from Bushehr province, southern Iran. Materials & Methods This is a descriptive-correlational study with a cross-sectional design that was conducted in 2022. Participants were 365 health workers from health centers affiliated to Bushehr University of Medical Sciences, who were selected by census method. The data was collected using a sociodemographic form, the Maslach Burnout Inventory, and the corona virus anxiety scale. SPSS software, version 16 was used for data analysis. Results Of 365 health workers, 308 completed the questionnaires. The majority of thm were female (69.5%) and married (85.7%). Their mean age and work experience were 37.8 and 13.9 years, respectively. The anxiety in most health workers (70.8%) was mild (Mean: 12.58 ±10.81). The findings also showed that 31.8% had moderate to severe emotional exhaustion; depersonalization was mostly low (82.1%), and about half had low personal achievement (49.7%). There was a significant relationship between COVID-19-related anxiety and emotional exhaustion (r=0.667; P

Background & Aims Pressure ulcers are one of the most important challenges in hospitals. One of the reasons for its occurrence is the low knowledge and practice of health care professionals. This study aims to determine the effect of online pressure ulcer prevention training on the knowledge, attitude and practice of nurses in intensive care units (ICUs). Materials & Methods This is a single-group study that was conducted on 73 nurses working in the ICUs of two teaching hospitals in Tehran, Iran. The sampling was done by continuous sampling method from April 2022 to January 2023. The data collectioin tools included a demographic form, the Pieper pressure ulcer knowledge test, the attitude towards pressure ulcer prevention questionnaire, and the practice of pressure ulcer prevention questionnaire completed before and one month after training. To analyze the data, paired t-test was used in SPSS software, Version 22. The significance level was set at 0.05. Results The mean knowledge score was 64.47±10.61 before the intervention and 70.47±10.48 after the intervention. Based on the results of the paired t-test, this difference was significant (P

—In order to provide access control on encrypted data, Attribute-based encryption (ABE) defines each user using a set of attributes. Fuzzy identity-based encryption (FIBE) is a variant of ABE that allows for a threshold access structure for users. To address the potential threat posed by future quantum computers, this paper presents a postquantum fuzzy IBE scheme based on lattices. However, current lattice-based ABE schemes face challenges related to computational complexity and the length of ciphertext and keys. This paper aims to improve the performance of an existing fuzzy IBE scheme by reducing key length and computational complexity during the encryption phase. While negative attributes are not utilized in our scheme, we prove its security under the learning with error (LWE) hard problem assumption in the selective security model. These improvements have significant implications for the field of ABE.

Soft power is a tool utilized by different actors in the evolving international system based on their capabilities. In this transformed international system, soft power becomes a vital element in increasing influence over international outcomes, as it makes it more difficult to coerce countries and non-state actors through traditional hard power tools that mean threats and force.The People's Republic of China is one of the influential actors in the realm of international relations. Its large economy, ranking second in the world, has enabled the country to utilize its economic power as a tool to advance its goals. According to most experts in the field of economics and international relations, China is projected to surpass the United States as the world's leading economy by 2030 and establish itself as a dominant economic power on the international stage, although Joseph Nye disputes this notion in his book "The Intelligent Power."Over the past few decades, China's foreign policy has pursued different dimensions and forms of power in the international arena, in line with its domestic environment and international circumstances. China's bitter historical experience in dealing with Western powers and enduring the era of humiliation, as well as the ideological components stemming from the Communist revolution, shaped its foreign policy during Mao's era with a strong hardware-oriented approach to power and a focus on win-lose dynamics. With the emergence of Deng Xiaoping, China's foreign policy outlook shifted towards a process of power acquisition and security enhancement. Since the 1990s, significant changes have occurred in China's domestic and international conditions, as the emphasis solely on one dimension of power made the country vulnerable to long-term interests. It was in the mid-1990s that soft power gained a special position in China's foreign policy. Jiang Zemin believed that due to various internal and international reasons, China had to incorporate new dimensions of power, including soft power, into its agenda to change its position and ensure security.Among the influential regions targeted by China, which shares over 1,800 kilometers of border with it, is Central Asia. This geographical proximity has fostered economic, political, and even cultural links between China and the countries of this region. The historical Silk Road, which originated in China and extended through Central Asia and Iran towards Europe, has strengthened these connections. In this regard, Chinese elites also strive to showcase their soft power on the global stage and in the direction of defeating enemies by utilizing the country's traditional culture, values, and teachings, combined with modern culture.The main objective of this research is to highlight China's development-oriented policies in the Central Asian region. The significance of this research lies in the fact that Central Asia is considered part of Iran's cultural sphere, and Iranian culture and art have a significant presence in this region. This research adopts a descriptive-analytical approach to answer the question of how the Chinese government employs soft power as a tool for its development ambitions in Central Asia. The article argues that by utilizing its soft power tools in cultural, political, and economic dimensions, the Chinese government influences the countries of the Central Asian region. However, it also faces challenges that hurt its soft power. This research examines the soft power of China, its capacities, tools, and challenges by addressing the concept of soft power and the Chinese government's utilization of it in Central Asia.Based on this, the research is structured into three main sections. The first section provides an overview and theoretical framework of the research. The second section explores China's soft power in Central Asia, including the existing tools and capacities of the Chinese government in this domain. The third section discusses the challenges faced by the Chinese government in leveraging its soft power.Considering that the main question of the research was how the Chinese government uses soft power as a tool for its expansionist ambitions in Central Asia, it is argued in this research that the Chinese government influences the countries of Central Asia through its soft power tools in cultural, political, and economic dimensions. However, it faces challenges such as the presence of regional and extra-regional powers (such as the United States, Russia, and India), Islamic fundamentalism, and cultural unattractiveness, which hurt its soft power. It can be concluded that China has been able to introduce itself as an influential variable in this region through its economic relations with Central Asian countries, both through the Shanghai Cooperation Organization and other frameworks. China has attempted to exert its influence on the development and progress of these countries by tying their economies to their own, creating consumer and transit markets, and utilizing the energy resources available in these countries. The Chinese government has placed economic tools as the foundation of its global and regional movements, particularly in Central Asia. In the cultural sphere, despite scholarships for students and the promotion of the Chinese language and Confucian culture, different perspectives, especially in neighboring countries, indicate that Russia and the United States have a relatively more desirable position in terms of China's soft power and influence. In the political sphere, there is authoritarianism in Central Asian countries, similar to China, but civil society and the general public in Central Asia do not find China's soft power politically appealing and prefer the liberal democracy model of the United States. Despite China's efforts to achieve its goals through initiatives such as the Shanghai Cooperation Organization and the Belt and Road Initiative, it faces challenges that have affected these initiatives. Russia considers Central Asia its domain and China's presence and influence in this region pass through Russia's channel. The United States identifies China as the biggest threat to its national security and seeks to have an influential presence in the region as an international player. Islamic fundamentalism (terrorism) is another challenge for China. The presence of Chinese semi-military forces in Syria in the form of the East Turkestan Islamic Movement and their return to Central Asia and China, creating security crises, makes Central Asian countries a potential center of terrorism in the future. Overall, it can be stated that despite all the progress China has made in this region, the existence of these challenges has affected China's soft power.

Background: With the increasing amount of elective spine fusion patients presenting with cardiac disease and congestive heart failure, it is becoming difficult to assess when it is safe to proceed with surgery. Assessing the severity of heart failure (HF) through ejection fraction may provide insight into patients' short- and long-term risks. Purpose: The purpose of this study was to assess the severity of HF on perioperative outcomes of spine fusion surgery patients. Study Design/Setting: This was a retrospective cohort study of the PearlDiver database. Patient Sample: We enrolled 670,526 patients undergoing spine fusion surgery. Outcome Measures: Thirty-day and 90-day complication rates, discharge destination, length of stay (LOS), physician reimbursement, and hospital costs. Methods: Patients undergoing elective spine fusion surgery were isolated and stratified by preoperative HF with preserved ejection fraction (P-EF) or reduced ejection fraction (R-EF) (International Classification of Diseases-9: 428.32 [chronic diastolic HF] and 428.22 [chronic systolic HF]). Means comparison tests (Chi-squared and independent samples t-tests, as appropriate) compared differences in demographics, diagnoses, comorbidities, procedural characteristics, LOS, 30-day and 90-day complication outcomes, and total hospital charges between those diagnosed with P-EF and those not R-EF. Binary logistic regression assessed the odds of complication associated with HF, controlling for levels fused (odds ratio [OR] [95% confidence interval]). Statistical significance was set at P < 0.05. Results: Totally 670,526 elective spine fusion patients were included. Four thousand and seventy-seven were diagnosed with P-EF and 2758 R-EF. Overall, P-EF patients presented with higher rates of morbid obesity, chronic kidney disease, chronic obstructive pulmonary disease, diabetes mellitus, and hypertension (all P < 0.001). In relation to No-HF, P-EF patients had higher rates of 30-day major complications including pulmonary embolism, pneumonia, cerebrovascular accident (CVA), myocardial infarctions (MI), sepsis, and death (all P < 0.001). Furthermore, P-EF was associated significantly with increased odds of pneumonia (OR: 2.07 [1.64–2.56], P < 0.001) and sepsis (OR: 2.09 [1.62–2.66], P < 0.001). Relative to No-HF, R-EF was associated with significantly higher odds of MI (OR: 3.66 [2.34–5.47]), CVA (OR: 2.70 [1.67–4.15]), and pneumonia (OR: 1.85 [1.40–2.40]) (all P < 0.001) postoperative within 30 days. Adjusting for prior history of MI, CAD, and the presence of a pacemaker R-EF was a significant predictor of an MI 30 days postoperatively (OR: 2.2 [1.14–4.32], P = 0.021). Further adjusting for history of CABG or stent placement, R-EF was associated with higher odds of CVA (OR: 2.11 [1.09–4.19], P = 0.028) and MI (OR: 2.27 [1.20–4.43], P = 0.013). Conclusions: When evaluating the severity of HF before spine surgery, R-EF was associated with a higher risk of major complications, especially the occurrence of a myocardial infarction 30 days postoperatively. During preoperative risk assessment, congestive HF should be considered thoroughly when thinking of postoperative outcomes with emphasis on R-EF.

Background: Adolescence is a high-risk period. Teenagers experience risky behaviors in this period, including using abusive drugs and addiction. Meanwhile, sufficient awareness helps a person to interpret and analyze health-threatening factors. This study aimed to determine the relationship between health literacy and susceptibility to addiction in adolescents living in the western part of Tehran City, Iran. Methods: This descriptive-correlational study was performed on 265 senior high school students in the western part of Tehran in 2021. The subjects were recruited by cluster random sampling. The study data were collected online using the addiction susceptibility questionnaire and health literacy measure for adolescents. The obtained data were sorted by frequency distribution, Mean±SD and analyzed utilizing the Pearson correlation coefficient, independent t-test, and analysis of variance in SPSS software, version 16. The significance level was set at 0.05. Results: Most study subjects (56.4%) were female. Their Mean±SD score of health literacy was 65.31±21.15. Among the subscales of health literacy, “calculation”, with a Mean±SD score of 68.96±35.89, and “utilization”, with 61.29±25.05, had the highest and lowest mean scores, respectively. The Mean±SD score of addiction susceptibility was 25.3±30.05, and among its subscales, “showing off” with a mean score of 33.09±32.64 and “family dissatisfaction” with 19.75±35.47 had the highest and lowest mean scores, respectively. Health literacy and its dimensions had a negative correlation with addiction susceptibility (P

Background: Although there are numerous animal models of polycystic ovary syndrome (PCOS), they often fail toaccurately replicate the reproductive and metabolic phenotypes associated with PCOS. The objective of this study isto assess oxidative status and inflammatory levels in a rat model of PCOS subjected to a new high-fat diet (HFD) incombination with letrozole.Materials and Methods: In this experimental study, mature, six-week-old female Sprague-Dawley rats (n=20) weredivided into four groups: control (standard diet); letrozole (letrozole plus a standard diet); HFD; and letrozole+HFD.After 16 weeks, the rats underwent vaginal smear analysis, measurement of hormonal and lipid profiles, and anoral glucose tolerance test (OGTT). Ovarian tissue morphology, oxidative parameters, and inflammatory status wereevaluated.Results: The experimental groups exhibited anoestrus profiles in the vaginal smears and abnormal ovarian morphology,which was not observed in the control group. Steroid hormone levels were significantly higher in theletrozole+HFD group compared to the other groups (P=0.00). The experimental groups also showed abnormal glucoselevels and lipid metabolism. The relative expression levels of inflammatory genes were significantly elevated inthe experimental groups compared to the control group (P=0.00), and the letrozole+HFD group exhibited the highestexpression level (P=0.00). The HFD, letrozole, and letrozole+HFD groups demonstrated significantly increased levelsof malondialdehyde (MDA) and reactive oxygen species (ROS), while the levels of enzymatic antioxidants weresignificantly reduced compared to the control group (P=0.00).Conclusion: The combination of a new HFD and letrozole treatment induces inflammation and oxidative stress (OS)in a rat model of PCOS. This model accurately exhibits abnormal metabolic phenotypes and disruptions in hormonalprofiles associated with PCOS.

Lemuru (Sardinella lemuru) merupakan salah satu ikan pelagis kecil yang banyak dimanfaatkan oleh masyarakat di Pulau Lombok, tidak hanya dalam pemenuhan kebutuhan pangan skala rumah tangga, namun juga dijadikan sebagai salah satu bahan baku pada skala industri. Keadaan tersebut menyebabkan tingginya tingkat pemanfaatan ikan lemuru di Provinsi Nusa Tenggara Barat (NTB). Teluk Awang merupakan salah satu sentra penangkapan lemuru di provinsi tersebut. Penelitian ini bertujuan untuk mengetahui dan mendeskripsikan kondisi populasi dan status keberlanjutan perikanan lemuru di Teluk Awang berdasarkan kondisi biologi perikanannya. Pengambilan sampel ikan lemuru dilakukan di Teluk Awang selama bulan Juli-Augustus tahun 2022. Sampel ikan (n=306 ekor) diukur panjang dan beratnya. Dari hasil pengamatan diketahui bahwa populasi ikan lemuru memiliki pola pertumbuhan alometrik negatif yang artinya bentuk tubuhnya kurus. Populasi ikan tersebut didominasi lemuru muda dengan ukuran kisaran panjang cagak 6,40-16,20 cm dan berat 3,0-39,0 g. Lemuru yang layak maturasi sebanyak 30%, layak tangkap 30%, dan layak konsumsi 37%. Nilai parameter kelayakan yang berkisar di bawah 50% mengindikasikan bahwa kegiatan perikanan lemuru selama bulan Juli-Agustus dapat dikatakan kurang berkelanjutan. Hasil penelitian ini dapat digunakan sebagai salah satu informasi dasar bagi pemerintah daerah setempat dalam menyusun kebijakan pengelolaan perikanan lemuru di Provinsi NTB.

Abstract Due to the exponential rise of ICT technologies, the digital banking industry has made tremendous advancements in user-friendly, effective, and quick financial transactions. Numerous new banking services, products, and business opportunities have resulted as a result. Smart facial authentication is a cutting-edge technology used in mobile banking. Users can utilize this technology to verify their identification by using the facial recognition feature of the camera on their mobile device. This method makes use of complex algorithms that can analyze a person’s face and extract the distinctive characteristics that can be seen there. The attributes of the images of distinct persons are then categorized using learning algorithms and the K-means clustering method. An artificial neural network (ANN), adaptive neural fuzzy inference system (ANFIS), and decision tree (DT) computer system are used to authenticate persons. In this inquiry, the face is used. Additionally, the Wild Horse Optimizer (WHO) method has been used to enhance the precision and optimization of machine learning systems by weighting cluster features. Fuzzy logic is used to make decisions about authentication based on the results of machine learning algorithms. The best feature from a broad dataset is selected using a technique based on evolutionary algorithms. The simulation findings for diverse users have a precision of about 99.78% for user authentication of test samples. Notably, the suggested method reduced the FAR, FRR, and ERR errors by 0.23, 1.13, and 1.1, respectively. It has been proven that using people’s image data may enhance the quality of everyday cameras, and it is anticipated that this work will be applied to mobile banking applications to ensure the verification of rightful owners.

Abstract Enzyme therapy can be an appropriate treatment option for celiac disease (CeD). Here, we developed Bromelain-Loaded Nanocomposites (BLNCs) to improve the stability and retention of bromelain enzyme activity. After the characterization of BLNCs, the cytotoxicity of BLNCs was determined on the Caco-2 cell line. The effect of BLNCs on gliadin degradation and the production of pro-inflammatory cytokines and anti-inflammatory molecules in peripheral blood mononuclear cells (PBMCs) obtained from celiac patients were assessed. Furthermore, the expression of CXCR3 and CCR5 genes was measured in CaCo-2 cells treated with gliadin, gliadin-digested with BLNCs, and bromelain. Our study demonstrated that the Bromelain entrapment efficiency in these nanoparticles was acceptable, and BLNCs have no toxic effect on cells. SDS-PAGE confirmed the digestion effect of bromelain released from nanocomposites. When Caco-2 cells were treated with gliadin digested by free bromelain and BLNCs, the expression of CXCR3 and CCR5 genes was significantly decreased. PBMCs of celiac patients treated with Bromelain and BLNCs decreased inflammatory cytokines (IL-1β, IL-6, TNF-α, and IFN-γ) production compared to untreated PBMCs. This treatment also increased IL-10 and CTLA-4 in PBMCs of CeD patients. According to the promising results of this study, we can hope for the therapeutic potential of BLNCs for CeD.

Background: Parental self-efficacy as an important factor in reducing children's educational and personality disorders is influenced by various factors, among them are parenting styles. So far, no study has been conducted on the effect of parenting training based on self-determination theory on the self-efficacy of parents. Aims: The purpose of this study is to investigate the effectiveness of the parenting training package based on the self-determination theory on parenting self-efficacy. Methods: The present research is based on quantitative and qualitative data type, prospective in terms of time and an exploratory mixed research regarding the aim. First, a parenting training package based on the theory of self-determination was compiled and after confirming validity and reliability by experts, in order to investigate its impact on parenting self-efficacy, 40 parents with a children aged 7 to 11 years in Damavand city were selected by purposive sampling, divided into two groups, experimental and control, and completed the parenting self-efficacy scale (Domka, 1996) in the pre-test and post-test stages. Results: The results of the analysis of covariance (ANCOVA) showed that the F value (P< 0.01, F= 14.21) for the effect of the independent variable (group) on the parenting self-efficacy score was statistically significant and the parenting self-efficacy of mothers who underwent the intervention was more than the parents of the control group and the effect size is 33%. Conclusion: In line with past research, it was found that the use of self-determination in parenting improves the self-efficacy of parents in regard to raising children properly, and Domka self-efficacy questionnaire can be used in family studies.

The target of this research is recognition of the alteration zones utilizing concentration-area fractal methodology according to the reflection of the main minerals of each alteration zone that enhanced by Spectral Feature Fitting (SFF) Method due to Advanced Space-borne Thermal Emission and Reflection Radiometer (ASTER) satellite images in Saryazd porphyry system, central Iran. The alterations and mineralization are developed in Eocene volcanics. Remote sensing results achieved by the SFF method and Concentration-Area (C-A) fractal modeling represent different parts of propylitic, argillic and phyllic alteration zones due to their intensity and pixel values. In addition, the results reveal that there is a ring-shaped structure in the alteration zones, which are correlated with results, derived from X-Ray Diffraction (XRD) analyses and field observations.

ObjectiveThis systematic review and meta-analysis was conducted to compare the benefits of adrenalectomy and conservative treatment for comorbidities associated with mild autonomous cortisol secretion (MACS) in patients diagnosed with MACS.BackgroundMACS is the most common benign hormone-secreting functional adrenal incidentaloma. Overproduction of cortisol is observed in MACS patients, resulting in a variety of long-term health issues, including arterial hypertension (HTN), diabetes mellitus (DM), dyslipidemia, obesity, and osteoporosis; however, the classic clinical manifestations of Cushing’s syndrome (CS) are not present.MethodsA systematic search was conducted using MEDLINE, Embase, Web of Sciences, and Scopus databases on December, 2023. Two reviewers independently extracted data and assessed the quality of the included articles. A meta-analysis was performed to compare the beneficial effects of adrenalectomy versus conservative management for MACS-related comorbidities.ResultsFifteen articles were included in this study, which evaluated 933 MACS patients (384 Adrenalectomy and 501 Conservative treatment, and 48 excluded due to incomplete follow-up duration). MACS diagnosis criteria were different among the included articles. All studies, however, stated that there must be no overt CS symptoms. Meta-analysis demonstrates the overall advantage of adrenalectomy over conservative treatment for MACS-related comorbidities (Cohen’s d = -0.49, 95% CI [-0.64, -0.34], p = 0.00). Subgroup analysis indicated that the systolic blood pressure (pooled effect size = -0.81, 95% CI [-1.19, -0.42], p = 0.03), diastolic blood pressure (pooled effect size = -0.63, 95% CI [-1.05, -0.21], p = 0.01), and BMD (pooled effect size = -0.40, 95% CI [-0.73, -0.07], p = 0.02) were significantly in favor of adrenalectomy group rather than conservative treatment but no significant differences between the two treatment groups in other MACS-related comorbidities were reported.ConclusionDespite the limited and diverse data, this study demonstrates the advantage of adrenalectomy over conservative treatment for MACS-related comorbidities.

Reporting clinical cases of high-grade endometrial stromal sarcoma tumors is essential for a better understanding of their natural course and for the development of appropriate diagnostic and treatment strategies. To date, only a few cases have been studied in this regard.In the present study, the authors present the case of a 69-year-old Iranian woman diagnosed with high-grade endometrial stromal sarcoma involving the myometrium and ovaries. The diagnosis was confirmed after pathology, which revealed myometrial and vascular involvement. The patient underwent total abdominal hysterectomy, bilateral salpingo-oophorectomy, and adjuvant chemotherapy with chemotherapy regimens.

Introduction Peripheral artery disease (PAD) is a major risk factor for cardiovascular morbidity and mortality, despite surgical and endovascular treatments. Emerging evidence supports the use of immediate antithrombotic medications after endovascular intervention for PAD, however, there is a lack of consensus regarding choice and duration of antithrombotic therapy. Prescriber decision-making is a complex process, with prior studies demonstrating patient factors can influence variability in antithrombotic therapy for PAD. However, it remains unclear the relative contribution of these factors. This paper describes a planned study that aims to (1) determine the influence of patient factors on clinician preference for antithrombotic therapy following endovascular intervention and (2) compare differences in prescribing preferences between consultant vascular surgeons and trainees.Methods and analysis This cross-sectional survey will evaluate antithrombotic prescribing choices using a discrete choice experiment (DCE) that has been developed and piloted for this study. A list of attributes and levels was generated using a mixed-methods approach. This included an extensive literature review and semistructured interviews with prescribing clinicians. Following final selection of included attributes, specialised software was used to construct a D-efficient design for the DCE questionnaire. The electronic questionnaire will be administered to vascular trainees and consultant surgeons across Australia. These data will be analysed using multinomial logistic regression, treating the decision to prescribe antithrombotic therapy as a function of both the attributes of the two alternatives, as well as characteristics of the respondent. Latent class analysis will be used to explore heterogeneity of responses.Ethics and dissemination Ethics approval was obtained from the University of Sydney Human Ethics committee (2023/474). The results of this study will be published in peer-reviewed journals and presented at national vascular surgical conferences. These results will be used to improve understanding how clinicians make prescribing decisions and to inform future strategy to enhance guideline-directed prescribing.

The world has lived an exceptional time period caused by the Coronavirus pandemic. To limit Covid-19 propagation, governments required people to wear a facial mask outside. In facial data analysis, mask-wearing on the human face creates predominant occlusion hiding the important oral region and causing more challenges for human face recognition and categorisation. The appropriation of existing solutions by taking into consideration the masked context is indispensable for researchers. In this paper, we propose an approach for mask-wearing prediction and adaptive facial human-gender classification. The proposed approach is based on convolutional neural networks (CNNs). Both mask-wearing and gender information are crucial for various possible applications. Experimentation shows that mask-wearing is very well detectable by using CNNs and justifies its use as a prepossessing step. It also shows that retraining with masked faces is indispensable to keep up gender classification performances. In addition, experimentation proclaims that in a controlled face-pose with acceptable image quality' context, the gender attribute remains well detectable. Finally, we show empirically that the adaptive proposed approach improves global performance for gender prediction in a mixed context.

IntroductionPost-traumatic stress disorder (PTSD) after an injury such as accidents is common in children and can affect their overall physical and mental functioning and quality of life. Early intervention can have significant health benefits for children. This study aimed to investigate the effectiveness of web-based training for parents on post-traumatic stress disorder in children.MethodThis was a quasi-experimental study with intervention and control group. 110 parents of children aged 10–18 years with PTSD after a traumatic event were selected through available sampling and assigned to intervention and control groups. Data was collected by a researcher-made demographic questionnaire and the Child Revised Impact of Events Scale (CRIES-8). Parents in the intervention group received a 4-week training course through a researcher-designed website, but the control group received routine care by the clinical team, which the main focus of care and training was on the physical aspects of the disease, and no intervention was done for PTSD. Two weeks after the intervention, the level of child stress was measured and compared in both groups. Data were analyzed using SPSS V.22.ResultsThe difference between the mean score of total traumatic stress and its subscales before intervention was not statistically significant (p = 0.23). But after intervention, the mean score of total traumatic stress and its subscales decreased in the intervention group and increased in the control group and this difference was statistically significant (p

This paper presents a novel approach for secure communication utilizing a chaotic hybrid optical bistable system and chaotic modulation. The proposed crypto system encrypts the message at the transmitter using the chaotic hybrid optical bistable system with decorrelation operation to improve the chaotic sequence's performance. The encoded message is then injected into the dynamics of the chaotic memristor system. At the receiver, the synchronization of the two chaotic systems with passive control and predictive control allows for the recovery of the message through chaotic demodulation. The effectiveness of this approach is demonstrated through numerical simulation using medical images.

Abstract Background Autologous bone grafts are the gold standard for spinal fusion; however, harvesting autologous bone can result in donor site infection, hematomas, increased operative time, and prolonged pain. Cellular bone allografts (CBAs) are a viable alternative that avoids the need for bone harvesting and may increase fusion success alone or when used as an adjunct material. The present study examined the efficacy and safety of CBA when used as an adjunct graft material to lumbar arthrodesis. Methods A prospective, single-arm, multicenter clinical trial (NCT 02969616) was conducted in adult subjects (> 18 years of age) undergoing lumbar spinal fusion with CBA graft (CBA used as primary (≥ 50% by volume), with augmentation up to 50%). Radiographic fusion status was assessed by an independent review of dynamic radiographs and CT scans. Clinical outcomes were assessed with the Oswestry Disability Index (ODI), and Visual Analog Scales (VAS) score for back and leg pain. Adverse events were assessed through the 24-month follow-up period. The presented data represents an analysis of available subjects (n = 86) who completed 24 months of postoperative follow-up at the time the data was locked for analysis. Results Postoperative 24-month fusion success was achieved in 95.3% of subjects (n = 82/86) undergoing lumbar spinal surgery. Clinical outcomes showed statistically significant improvements in ODI (46.3% improvement), VAS-Back pain (75.5% improvement), and VAS-Leg pain (85.5% improvement) (p

Nanotechnology in recent years helps researcehers to design flow rate and profile in microsized channel via making surface charge heterogenous. This paper numerically simulates the electroosmotic flow inside a microchannel with non-uniform Zeta potential (ZP). The problem is a two-dimensional, incompressible, steady, and laminar channel flow between two parallel plates. The numerical results show that the flow rate changes compared to a constant ZP by ascending, descending, and parabolic modifications of the wall ZP at the mid-length of the microchannel. Results show that flow volume rate increases by microchannel width from 4 mm3/s to 6.5 mm3/s in best condition.

The present paper investigates the flow field and heat transfer in a microchannel with incorporating surface hydrophobicity and considering its thickness. The microchannel is under partial magnetic field (MF), which is applied to the top thermal-insulated wall in Hartmann numbers 0 to 30. The results show that at Ha = 0, viscous dissipation (VD) and heat transfer decrease with increasing slip coefficient. Also, raising the Hartmann number (Ha) increases the friction coefficient. The Nusselt number (Nu) reaches its highest value at Ha = 20 for all cases, but then, as the Ha increases, the average Nu reduces.

Background & Aims Aging is associated with decreased physical and psychological functions. This study aims to investigate the ability to perform basic and instrumental activities of daily living (ADL) in elderly women with osteoporosis in Tehran, Iran. Materials & Methods This is a cross-sectional study conducted on 130 elderly women over 60 years of age referred to selected hospitals affiliated to Iran University of Medical Sciences in 2019-2020, who were selected by a consecutive sampling method. The data collection tools were a demographic form, the Barthel index for ADL, and the Lawton-Brody Instrumental ADL scale. The data was statistically analyzed in SPSS software, version 20. Results The mean age of the women was 67.5±5.7 years. None of them had dependency for performing ADLs such as eating. The highest dependence was for urination (54.62%). Regarding instrumental ADLs, the highest inability was related to shopping (60.77%), and the lowest inability was related to managing one's own medication use (0.77%). The scores of basic and instrumental ADLs were significantly related to age and educational level (P

Abstract Background Gram-negative bloodstream infections (GN-BSIs) are a significant clinical challenge. The utility of follow-up blood cultures (FUBCs) in GN-BSIs and their impact on mortality and antibiotic consumption are areas of debate. This study aimed to evaluate the effect of FUBCs on mortality and antibiotic consumption in patients with GN-BSIs. Methods This single-center, retrospective study was conducted in aged > 18 years of patients with GN-BSIs. FUBC was defined as a blood culture performed 2–7 days after the first blood culture. Patients were grouped as FUBC and no FUBC and compared. A 1:1 match analysis was performed between the groups according to the SOFA score. The matched subgroup was compared for mortality risk factors with logistic regression models. The two groups were compared for the duration of effective antibiotic therapy and total antibiotic consumption (days of therapy per 1000 patient days (DOT/1000 PD)). Results FUBC was performed in 564 (69.4%) of 812 patients. Persistent, positive and negative FUBC rates were 7.9%, 14%, and 78%, respectively. The frequency of persistent GN-BSI in patients with appropriate antibiotic therapy was 3.9%. SOFA score (OR:1.33; 95% CI, 1.23–1.44), Charlson comorbidity index score (OR:1.18; 95% CI, 1.08–1.28), hospital-acquired infections (OR:1.93; 95% CI, 1.08–3.46) and carbapenem-resistant GN-BSI (OR: 2.92; 95% CI, 1.72–4.96) were independent risk factors for mortality. No relationship was found between FUBC and mortality (p > 0.05). Duration of effective antibiotic therapy (10(4–16) vs. 15(9–20), p